CN110115713A - A kind of snore stopping liquid and preparation method thereof - Google Patents
A kind of snore stopping liquid and preparation method thereof Download PDFInfo
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- CN110115713A CN110115713A CN201910537399.XA CN201910537399A CN110115713A CN 110115713 A CN110115713 A CN 110115713A CN 201910537399 A CN201910537399 A CN 201910537399A CN 110115713 A CN110115713 A CN 110115713A
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Abstract
The present invention relates to field of medicine preparing technology, more particularly to a kind of snore stopping liquid and preparation method thereof, the snore stopping liquid, including active constituent, auxiliary material and ionized water, the active constituent includes sinapine, ferulic acid, Senkyunolide A, laetrile, Tween-80, glycerol, sodium chloride, edetate sodium, potassium sorbate and polyethylene glycol.Snore stopping liquid provided in the present invention can be improved the excitement levels of pharyngeal nerve, and patient is made also to be able to maintain airway open in sleep, avoid the occurrence of vortex vibration, to play the role of preventing snoring；And it is without any side effects, it is suitble to patient to be used for a long time, and the preparation method of snore stopping liquid provided by the invention, can sufficiently goes out except the bacterium in raw material and injection, improve the stability and storage time of snore stopping liquid.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to a kind of snore stopping liquid and preparation method thereof.
Background technique
Snoring also known as snores, snore disease, is a kind of generally existing sleep phenomenon.Many people think that snoring is the minister of public works in ancient china
See used and take exception to, also some people regard snoring as the performance to sleep soundly.Long-term snoring in fact is caused by internal disease,
Saw gourds not only influence the respiratory function of patient, but also the various diseases such as easily cause hypertension and cardiovascular and cerebrovascular, are health
Formidable enemy.Since the air flue of snorer is usually narrower than normal person, the contraction of bottleneck throat muscle compensatory makes air flue when daytime is awake
It keeps opening, not block.But nerve excitability declines when nighttime sleep, of flaccid muscles, and pharyngeal blocking makes epithelium healing
It collapses, when air-flow passes through narrow positions, generates and be vortexed and cause to vibrate, to the sound of snoring occur.Snoring patient has blood oxygen to contain more
Amount decline, thus be often accompanied by hypertension, arrhythmia, blood viscosity increase, heart burden is easy to cause cardiovascular and cerebrovascular disease
The generation of disease, can jeopardize the life of patient, or die suddenly toward contact when snoring serious.
Treatment snore disease can carry out treating and using Easy pillow using the method for operation, steroids western medicine at present
Head, although however operative treatment speed is fast, that there is pain is significant, bleeding is more, risk is big, it is costly, be also easy to produce operation simultaneously
Send out the defect of disease；Although steroids western medicine has certain curative effect using nervous excitation drug, takes Western medicine pair for a long time and make
With big, health is influenced, snore stopping pillow will affect the sleep quality of patient.
Summary of the invention
In view of the deficiencies of the prior art, an object of the present invention is to provide a kind of snore stopping liquid, it can be effectively reduced
Resistance of respiratory tract improves the situation that breathing is obstructed, and without any side effects.
The second object of the present invention is to provide a kind of preparation method of snore stopping liquid.
To achieve the goals above, one aspect of the present invention provides a kind of snore stopping liquid, including active constituent, auxiliary material and ion
Water, the active constituent include sinapine, ferulic acid, Senkyunolide A, Tween-80, glycerol, chlorination
Sodium, edetate sodium, potassium sorbate and polyethylene glycol；
Wherein, the mass concentration of the sinapine is 0.8 ~ 1.5wt%；The mass concentration of the ferulic acid
For 0.08 ~ 0.75wt%；The mass concentration of the Senkyunolide A is 0.04 ~ 0.3wt%；The mass concentration of the laetrile
For 0.16 ~ 0.6wt%；The mass concentration of the Tween-80 is 1 ~ 3wt%；The mass concentration of the glycerol is 5 ~ 15wt%；It is described
The mass concentration of sodium chloride is 0.8 ~ 1.5wt%；The mass concentration of the edetate sodium is 0.3 ~ 0.8wt%；The potassium sorbate
Mass concentration be 0.02 ~ 0.05wt%；The mass concentration of the polyethylene glycol is 0.5 ~ 3wt%.
Another aspect of the present invention provides the preparation method of snore stopping liquid described in one kind, comprising the following steps:
(1) by sinapine, ferulic acid, Senkyunolide A, laetrile, tartaric acid and bisulfite
Sodium is dissolved in ionized water, obtains medical fluid A；
(2) medical charcoal is added in medical fluid A and stirs 20 ~ 40min, be then filtered removing medical charcoal, be subsequently added into tween-
80, glycerol, sodium chloride, edetate sodium, potassium sorbate and polyethylene glycol, obtain medical liquid B；
(3) medical liquid B is filtered with 0.2 ~ 0.5 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen
Filling and sealing is carried out in stream, obtains snore stopping liquid semi-finished product；
(4) sterilize snore stopping liquid semi-finished product 15 ~ 30min at 110 ~ 115 DEG C.
Through the above technical solutions, the present invention has following technical effect that
(1) by the way that active constituent sinapine, ferulic acid, foreign Rhizoma Chuanxiong are added in snore stopping liquid in the present invention
Lactone A can be improved the excitement levels of pharyngeal nerve, so that patient is also able to maintain airway open in sleep, avoids the occurrence of whirlpool
Stream vibration, to play the role of preventing snoring.
(2) by the way that Tween-80, glycerol, sodium chloride, edetate sodium, potassium sorbate to be used cooperatively in the present invention, Neng Gourun
Pharyngeal mucous membrane is slided and softened, nasal cavity and throat wetting is kept, reduces respiratory resistance, avoid the occurrence of vortex and shake, thus
Play the role of preventing snoring.
(3) snore stopping liquid provided by the invention is without any side effects, and patient is suitble to be used for a long time.
(4) preparation method of snore stopping liquid provided by the invention can sufficiently go out except the bacterium in raw material and injection, improve
The stability and storage time of snore stopping liquid.
Other features and advantages of the present invention will the following detailed description will be given in the detailed implementation section.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The present invention provides a kind of snore stopping liquid, including active constituent, auxiliary material and ionized water, and the active constituent includes mustard seed
Alkali, ferulic acid, Senkyunolide A, Tween-80, glycerol, sodium chloride, edetate sodium, potassium sorbate and
Polyethylene glycol；Wherein, the mass concentration of the sinapine is 0.8 ~ 1.5wt%；The matter of the ferulic acid
Amount concentration is 0.08 ~ 0.75wt%；The mass concentration of the Senkyunolide A is 0.04 ~ 0.3wt%；The matter of the laetrile
Amount concentration is 0.16 ~ 0.6wt%；The mass concentration of the Tween-80 is 1 ~ 3wt%；The mass concentration of the glycerol be 5 ~
15wt%；The mass concentration of the sodium chloride is 0.8 ~ 1.5wt%；The mass concentration of the edetate sodium is 0.3 ~ 0.8wt%；Institute
The mass concentration for stating potassium sorbate is 0.02 ~ 0.05wt%；The mass concentration of the polyethylene glycol is 0.5 ~ 3wt%.
It was found by the inventors of the present invention that being made by sinapine, ferulic acid, Senkyunolide A cooperation
With, can be improved the excitement levels of pharyngeal nerve, make patient sleep when be also able to maintain airway open, avoid the occurrence of vortex shake
It is dynamic, to play the role of preventing snoring；In addition, by the way that Tween-80, glycerol, sodium chloride, edetate sodium, potassium sorbate are pressed
It is used cooperatively according to special ratios, additionally it is possible to lubricate and soften pharyngeal mucous membrane, keep nasal cavity and throat wetting, reduce breathing
Resistance avoids the occurrence of vortex vibration, to play the role of preventing snoring.
In the present invention, the content of active constituent is an important factor for influencing snore stopping liquid drug effect, under optimum condition, the mustard seed
The mass concentration of alkali is that 0.8 ~ 1.5wt%(for example can be 0.8wt%, 1wt%, 1.2wt%, 1.3wt%, 1.5wt% or above-mentioned two
Arbitrary value between a numerical value)；The mass concentration of the ferulic acid is that 0.2 ~ 0.36wt%(for example can be with
For 0.2wt%, 0.25wt%, 0.28wt%, 0.3wt%, 0.32wt%, the arbitrary value between 0.36wt% or above-mentioned two numerical value)；
It for example can be 0.1wt%, 0.12wt%, 0.15wt% that the mass concentration of the Senkyunolide A, which is 0.1 ~ 0.18wt%(,
Arbitrary value between 0.16wt%, 0.18wt% or above-mentioned two numerical value)；The mass concentration of the laetrile be 0.3 ~
0.5wt%(for example can be 0.3wt%, 0.35wt%, 0.4wt%, appointing between 0.45wt%, 0.5wt% or above-mentioned two numerical value
Meaning value)；It for example can be 1.5wt%, 1.8wt%, 2wt%, 2.2wt% that the mass concentration of the Tween-80, which is 1.5 ~ 2.5wt%(,
Arbitrary value between 2.5wt% or above-mentioned two numerical value)；The mass concentration of the glycerol is that 6 ~ 12wt%(for example can be
Arbitrary value between 6wt%, 8wt%, 10wt%, 12wt% or above-mentioned two numerical value)；The mass concentration of the sodium chloride be 1 ~
1.2wt%(for example can be 1wt%, the arbitrary value between 1.2wt% or above-mentioned two numerical value)；The quality of the edetate sodium is dense
It for example can be 0.5wt%, 0.6wt%, 0.7wt% that degree, which is 0.5 ~ 0.8wt%(, any between 0.8wt% or above-mentioned two numerical value
Value)；It for example can be 0.02wt%, 0.03wt%, 0.04wt% that the mass concentration of the potassium sorbate, which is 0.02 ~ 0.05wt%(,
Arbitrary value between 0.05wt% or above-mentioned two numerical value)；The mass concentration for stating polyethylene glycol is that 1 ~ 2.5wt%(for example can be
Arbitrary value between 1wt%, 1.5wt%, 2wt%, 2.5wt% or above-mentioned two numerical value).
The dissociated ion in injection can be complexed as complexing agent for auxiliary material mesotartaric acid, and sodium hydrogensulfite is as antioxidant
The antioxygenic property of injection can be improved, thus extend its storage time, under optimum condition, the mass concentration of the tartaric acid
It for example can be 0.002wt%, 0.003wt%, 0.004wt% for 0.002 ~ 0.005wt%(, 0.005wt% or above-mentioned two numerical value
Between arbitrary value)；The mass concentration of the sodium hydrogensulfite is that 0.02 ~ 0.05wt%(for example can be 0.02wt%,
Arbitrary value between 0.03wt%, 0.04wt%, 0.05wt% or above-mentioned two numerical value).
Under optimum condition, the matter of the sinapine, the ferulic acid and the Senkyunolide A
Amount concentration ratio is 1:(0.1 ~ 0.5): (0.05 ~ 0.2), preferably 1:(0.2 ~ 0.3): (0.1 ~ 0.15), more preferably 1:0.25:
0.12。
Under optimum condition, the sinapine, laetrile mass concentration ratio be 1:(0.2 ~ 0.4), more preferably 1:
0.3。
Under optimum condition, the Tween-80, glycerol mass concentration ratio be 1:3 ~ 8, more preferably 1:4 ~ 6, more preferably
1:5。
In the present invention, snore stopping liquid is direct instillation nasal cavity, and the snore stopping liquid of liquid is easy to flow out from nasal cavity, causes
In nasal cavity the snore stopping liquid effective concentration of active constituent be lower, active constituent action time it is shorter, thus make the drug effect of snore stopping liquid by
To limitation.In the present invention, polyethylene glycol is added in nasal drops, reduces the mobility of snore stopping liquid, snore stopping liquid is enable to play
Long-acting；In addition, polyethylene glycol can also make active constituent slow release, can either avoid when nasal drops is initially added dropwise,
It is uncomfortable caused by diseased region drug concentration is excessively high, it can also make sustained release drug, have the function that long-acting treatment；Poly- second
Glycol can also play moisture-keeping function to site of action, further keep nasal cavity and throat wetting, reduce respiratory resistance.
Under optimum condition, the polyethylene glycol in PEg 300, PEG400, PEG600, PEG2000 and PEG4000 at least one
Kind, it is further preferred that the PEG is 1:(2 ~ 4 according to weight ratio by PEG600 and PEg 300) it forms, it is furthermore preferred that described
PEG is made of PEG600 and PEg 300 according to weight ratio for 1:3.
The present invention also provides a kind of preparation methods of snore stopping liquid, comprising the following steps:
(1) by sinapine, ferulic acid, Senkyunolide A, laetrile, tartaric acid and bisulfite
Sodium is dissolved in ionized water, obtains medical fluid A；
(2) medical charcoal is added in medical fluid A and stirs 20 ~ 40min, be then filtered removing medical charcoal, be subsequently added into tween-
80, glycerol, sodium chloride, edetate sodium, potassium sorbate and polyethylene glycol, obtain medical liquid B；
(3) medical liquid B is filtered with 0.2 ~ 0.5 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen
Filling and sealing is carried out in stream, obtains snore stopping liquid semi-finished product；
(4) sterilize snore stopping liquid semi-finished product 15 ~ 30min at 110 ~ 115 DEG C.
Under optimum condition, total dosage of the medical charcoal is 0.05 ~ 0.15wt% of the snore stopping liquid total weight.
The present invention will be described in detail by way of examples below.
Embodiment 1
A kind of snore stopping liquid, the foreign river of the ferulic acid of sinapine, 0.25wt% including 1wt%, 0.12wt%
The laetrile of rhizome of chuanxiong lactone A, 0.3wt%, the Tween-80 of 2.5wt%, the glycerol of 15wt%, the sodium chloride of 1.2wt%, 0.6wt%
Edetate sodium, the potassium sorbate of 0.03wt%, the PEg 300 of PEG600,1.5wt% of 0.5wt%, 0.003wt% tartaric acid and
The sodium hydrogensulfite of 0.03wt%, surplus and ionized water.
The snore stopping liquid the preparation method is as follows:
(1) by 1g sinapine, 0.25g ferulic acid, 0.12g Senkyunolide A, 0.3g laetrile,
0.3g tartaric acid and 0.03g sodium hydrogensulfite are dissolved in ionized water, obtain medical fluid A；
(2) 1g medical charcoal is added in medical fluid A and stirs 30min, be then filtered removing medical charcoal, be subsequently added into spitting for 2.5g
Warm -80, PEG600,1.5g of the glycerol of 15g, the sodium chloride of 1.2g, the edetate sodium of 0.6g, the potassium sorbate of 0.03g, 0.5g
PEg 300, obtain medical liquid B；
(3) medical liquid B is filtered with 0.22 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen stream
Filling and sealing is carried out, snore stopping liquid semi-finished product are obtained；
(4) snore stopping liquid semi-finished product are sterilized 20min at 112 DEG C, obtains snore stopping liquid A1.
Embodiment 2
A kind of snore stopping liquid, the ocean of the ferulic acid of sinapine, 0.36wt% including 1.2wt%, 0.18wt%
4,5-dihydro-3-butylidene-phthalide, the laetrile of 0.5wt%, the Tween-80 of 3wt%, the glycerol of 12wt%, the sodium chloride of 1wt%, 0.5wt% according to
Ground acid sodium, the potassium sorbate of 0.05wt%, the PEg 300 of PEG600,2wt% of 0.5wt%, 0.003wt% tartaric acid and
The sodium hydrogensulfite of 0.03wt%, surplus and ionized water；
The snore stopping liquid the preparation method is as follows:
(1) by 12g sinapine, 0.36g ferulic acid, 0.18g Senkyunolide A, 0.5g vitamin
B17,0.003g tartaric acid and 0.03g sodium hydrogensulfite are dissolved in ionized water, obtain medical fluid A；
(2) 1.5g medical charcoal is added in medical fluid A and stirs 25min, be then filtered removing medical charcoal, be subsequently added into spitting for 3g
Temperature -80, the glycerol of 12g, the sodium chloride of 1g, the edetate sodium of 0.5g, the potassium sorbate of 0.05g, 0.5g PEG600,2g
PEg 300, obtains medical liquid B；
(3) medical liquid B is filtered with 0.22 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen stream
Filling and sealing is carried out, snore stopping liquid semi-finished product are obtained；
(4) snore stopping liquid semi-finished product are sterilized 30min at 110 DEG C, obtains snore stopping liquid A2.
Embodiment 3
A kind of snore stopping liquid, the foreign Rhizoma Chuanxiong of the ferulic acid of sinapine, 0.2wt% including 1wt%, 0.1wt%
The laetrile of lactone A, 0.3wt%, the Tween-80 of 2wt%, the glycerol of 6wt%, the sodium chloride of 1.2wt%, 0.8wt% according to ground
Sour sodium, the potassium sorbate of 0.02wt%, the PEg 300 of PEG600,0.7wt% of 0.3wt%, 0.004wt% tartaric acid and
The sodium hydrogensulfite of 0.04wt%, surplus and ionized water.
The snore stopping liquid the preparation method is as follows:
(1) by 10g sinapine, 0.2g ferulic acid, 0.1g Senkyunolide A, 0.3g laetrile,
0.004g tartaric acid and 0.04g sodium hydrogensulfite are dissolved in ionized water, obtain medical fluid A；
(2) 0.5g medical charcoal is added in medical fluid A and stirs 35min, be then filtered removing medical charcoal, be subsequently added into spitting for 2g
Warm -80, PEG600,0.7g of the glycerol of 6g, the sodium chloride of 1.2g, the edetate sodium of 0.8g, the potassium sorbate of 0.02g, 0.3g
PEg 300, obtain medical liquid B；
(3) medical liquid B is filtered with 0.22 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen stream
Filling and sealing is carried out, snore stopping liquid semi-finished product are obtained；
(4) snore stopping liquid semi-finished product are sterilized 15min at 115 DEG C, obtains snore stopping liquid A3.
Embodiment 4
A kind of snore stopping liquid, the foreign river of the ferulic acid of sinapine, 0.75wt% including 1.5wt%, 0.3wt%
The laetrile of rhizome of chuanxiong lactone A, 0.6wt%, the Tween-80 of 1.5wt%, the glycerol of 12wt%, the sodium chloride of 1.5wt%, 0.3wt%
Edetate sodium, the potassium sorbate of 0.05wt%, the PEg 300 of 0.5wt%, the tartaric acid of 0.002wt% and the sulfurous acid of 0.02wt%
Hydrogen sodium, surplus and ionized water.
The snore stopping liquid the preparation method is as follows:
(1) by 15g sinapine, 0.75g ferulic acid, 0.3g Senkyunolide A, 0.1g laetrile,
0.002g tartaric acid and 0.02g sodium hydrogensulfite are dissolved in ionized water, obtain medical fluid A；
(2) 1g medical charcoal is added in medical fluid A and stirs 40min, be then filtered removing medical charcoal, be subsequently added into spitting for 1.5g
Warm -80, the PEg 300 of the glycerol of 1g, the sodium chloride of 1.5g, the edetate sodium of 0.3g, the potassium sorbate of 0.05wt%, 0.5g, obtains
To medical liquid B；
(3) medical liquid B is filtered with 0.22 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen stream
Filling and sealing is carried out, snore stopping liquid semi-finished product are obtained；
(4) snore stopping liquid semi-finished product are sterilized 15min at 110 DEG C, obtains snore stopping liquid A4.
Embodiment 5
A kind of snore stopping liquid, the ocean of the ferulic acid of sinapine, 0.08wt% including 0.8wt%, 0.04wt%
4,5-dihydro-3-butylidene-phthalide, the laetrile of 0.16wt%, the Tween-80 of 1wt%, the glycerol of 5wt%, the sodium chloride of 0.8wt%, 0.8wt%
Edetate sodium, the potassium sorbate of 0.02wt%, the PEg 300 of 3wt%, the tartaric acid of 0.005wt% and the bisulfite of 0.05wt%
Sodium, surplus and ionized water.
The snore stopping liquid the preparation method is as follows:
(1) by 8g sinapine, 0.08g ferulic acid, 0.04g Senkyunolide A, 0.16g vitamin
B17,0.005g tartaric acid and 0.05g sodium hydrogensulfite are dissolved in ionized water, obtain medical fluid A；
(2) 1g medical charcoal is added in medical fluid A and stirs 20min, be then filtered removing medical charcoal, be subsequently added into spitting for 1g
Warm -80, the PEg 300 of the glycerol of 5g, the sodium chloride of 0.8g, the edetate sodium of 0.8g, the potassium sorbate of 0.02g, 3g, obtains medicine
Liquid B；
(3) medical liquid B is filtered with 0.22 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen stream
Filling and sealing is carried out, snore stopping liquid semi-finished product are obtained；
(4) snore stopping liquid semi-finished product are sterilized 30min at 115 DEG C, obtains snore stopping liquid A5.
Embodiment 6
According to the method for embodiment 1, unlike, the sinapine, the ferulic acid and the foreign river
The mass concentration ratio of rhizome of chuanxiong lactone A is 1:0.5:0.2, and raw material group becomes a kind of snore stopping liquid, sinapine, 0.5wt% including 1wt%
Ferulic acid, the Senkyunolide A of 0.2wt%, the laetrile of 0.3wt%, 2.5wt% tween-
80, the glycerol of 15wt%, the sodium chloride of 1.2wt%, the edetate sodium of 0.6wt%, the potassium sorbate of 0.03wt%, 0.5wt%
PEg 300, the tartaric acid of 0.003wt% and the sodium hydrogensulfite of 0.03wt% of PEG600,1.5wt%, surplus and ionized water, obtain
To snore stopping liquid A6.
Embodiment 7
According to the method for embodiment 1, unlike, the sinapine, the ferulic acid and the foreign river
The mass concentration ratio of rhizome of chuanxiong lactone A is 1:0.1:0.05, raw material composition are as follows: the 3- methoxyl group -4- of the sinapine of 1wt%, 0.1wt%
Hydroxycinnamic acid, the Senkyunolide A of 0.05wt%, the laetrile of 0.3wt%, the Tween-80 of 2.5wt%, 15wt% it is sweet
PEG600,1.5wt% of oil, the sodium chloride of 1.2wt%, the edetate sodium of 0.6wt%, the potassium sorbate of 0.03wt%, 0.5wt%
The sodium hydrogensulfite of PEg 300, the tartaric acid of 0.003wt% and 0.03wt%, surplus and ionized water obtain snore stopping liquid A7.
Embodiment 8
According to the method for embodiment 1, unlike, the sinapine, laetrile mass concentration ratio be 1:0.2, raw material
Composition are as follows: the sinapine of 1wt%, the ferulic acid of 0.25wt%, 0.12wt% Senkyunolide A,
The laetrile of 0.2wt%, the Tween-80 of 2.5wt%, the glycerol of 15wt%, the sodium chloride of 1.2wt%, 0.6wt% edetic acid(EDTA)
Sodium, the potassium sorbate of 0.03wt%, the PEg 300 of PEG600,1.5wt% of 0.5wt%, 0.003wt% tartaric acid and 0.03wt%
Sodium hydrogensulfite, surplus and ionized water obtain snore stopping liquid A8.
Embodiment 9
According to the method for embodiment 1, unlike, the sinapine, laetrile mass concentration ratio be 1:0.4, raw material
Composition are as follows: the sinapine of 1wt%, the ferulic acid of 0.25wt%, 0.12wt% Senkyunolide A,
The laetrile of 0.4wt%, the Tween-80 of 2.5wt%, the glycerol of 15wt%, the sodium chloride of 1.2wt%, 0.6wt% edetic acid(EDTA)
Sodium, the potassium sorbate of 0.03wt%, the PEg 300 of PEG600,1.5wt% of 0.5wt%, 0.003wt% tartaric acid and 0.03wt%
Sodium hydrogensulfite, surplus and ionized water obtain snore stopping liquid A9.
Embodiment 10
According to the method for embodiment 1, unlike, Tween-80, glycerol mass concentration ratio be 1:2, raw material composition are as follows:
The sinapine of 1wt%, the ferulic acid of 0.25wt%, the Senkyunolide A of 0.12wt%, the dimension of 0.4wt% are raw
The mountain of the Tween-80 of plain B17,2.5wt%, the glycerol of 5wt%, the sodium chloride of 1.2wt%, the edetate sodium of 0.6wt%, 0.03wt%
Potassium sorbate, the PEg 300 of PEG600,1.5wt% of 0.5wt%, the tartaric acid of 0.003wt% and the sodium hydrogensulfite of 0.03wt%,
Surplus and ionized water obtain snore stopping liquid A10.
Comparative example 1
According to the method for embodiment 1, unlike, sinapine is not contained in snore stopping liquid, obtains snore stopping liquid B1.
Comparative example 2
According to the method for embodiment 1, unlike, snore stopping liquid does not contain ferulic acid, obtains snore stopping liquid
B2。
Comparative example 3
According to the method for embodiment 1, unlike, Senkyunolide A is free of in snore stopping liquid, obtains snore stopping liquid B3.
Comparative example 4
According to the method for embodiment 1, unlike, without foreign laetrile in snore stopping liquid, snore stopping liquid B4 is obtained.
Comparative example 5
According to the method for embodiment 1, unlike, polyethylene glycol is not contained in snore stopping liquid, obtains snore stopping liquid B5.
Application method: the application method for the snore stopping liquid that the embodiment of the present invention 1 ~ 10 is prepared are as follows: 10 ~ 30min before sleeping,
3 ~ 5 drop snore stopping liquid of drop faces upward head and keeps 30 ~ 60s to oral cavity.
Experimental example
1, stability test
Snore stopping liquid A1 ~ the A13 and B1 ~ B15 that embodiment 1 ~ 13 and comparative example 1 ~ 15 are obtained are respectively in 60 DEG C, Qiang Guang (4500lx)
It is lower to place 60 days, detect its character, using the content of high performance liquid chromatography detection sinapine, and calculate sinapine containing quantitative change
Change value, wherein experimental result is as shown in table 1.
In changes of contents value=sample to be tested in content/initial sample of sinapine sinapine content × 100%
Table 1
2, efficacy evaluation
Model foundation: choosing male Wistar rat 800, weight about 300g, and free diet tests preceding adaptable fed one
It week chooses 750 good rats of the state of mind and is randomly divided into 15 groups, every group 50, after rat anesthesia, in opposite side tongue palate
Sodium Hyaluronate is injected at bow, pharyngopalatine arch and the root of the tongue, until rat apnea occurs and observes exhaling for rat after injection stops
Situation is inhaled, its death by suffocation is prevented；
Sleep monitor: after model foundation four weeks, the snore relieving of embodiment 1 ~ 10 and comparative example 1 ~ 5 is added dropwise in rat oral cavity respectively
Liquid carries out 4 hours sleep monitors, and using multiple tracks hypnotic instrument, (Neurotronick company is produced, and Polysmith sleep analysis is soft
Part) monitoring rat sleep state, experimental result is as shown in table 2.
Wherein, blank group is male Wistar rat without any processing.
AI is apnea number, and Ltime is the longest apnea time.
Table 2
The preferred embodiment of the present invention has been described above in detail, still, the tool during present invention is not limited to the embodiments described above
Body details within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, these letters
Monotropic type all belongs to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. a kind of snore stopping liquid, including active constituent, auxiliary material and ionized water, which is characterized in that the active constituent include sinapine,
Ferulic acid, Senkyunolide A, laetrile, Tween-80, glycerol, sodium chloride, edetate sodium, sorb
Sour potassium and polyethylene glycol；
Wherein, the mass concentration of the sinapine is 0.8 ~ 1.5wt%；
The mass concentration of the ferulic acid is 0.08 ~ 0.75wt%；
The mass concentration of the Senkyunolide A is 0.04 ~ 0.3wt%；
The mass concentration of the laetrile is 0.16 ~ 0.6wt%；
The mass concentration of the Tween-80 is 1 ~ 3wt%；
The mass concentration of the glycerol is 5 ~ 15wt%；
The mass concentration of the sodium chloride is 0.8 ~ 1.5wt%；
The mass concentration of the edetate sodium is 0.3 ~ 0.8wt%；
The mass concentration of the potassium sorbate is 0.02 ~ 0.05wt%；
The mass concentration of the polyethylene glycol is 0.5 ~ 3wt%.
2. snore stopping liquid according to claim 1, which is characterized in that the mass concentration of the sinapine is 0.8 ~ 1.5wt%；
And/or
The mass concentration of the ferulic acid is 0.2 ~ 0.36wt%；And/or
The mass concentration of the Senkyunolide A is 0.1 ~ 0.18wt%；And/or
The mass concentration of the laetrile is 0.3 ~ 0.5wt%；And/or
The mass concentration of the Tween-80 is 1.5 ~ 2.5wt%；And/or
The mass concentration of the glycerol is 6 ~ 12wt%；And/or
The mass concentration of the sodium chloride is 1 ~ 1.2wt%；And/or
The mass concentration of the edetate sodium is 0.5 ~ 0.8wt%；And/or
The mass concentration of the potassium sorbate is 0.02 ~ 0.05wt%；And/or
The mass concentration of the polyethylene glycol is 1 ~ 2.5wt%.
3. snore stopping liquid according to claim 1, which is characterized in that the auxiliary material includes tartaric acid and sodium hydrogensulfite；
The mass concentration of the tartaric acid is 0.002 ~ 0.005wt%, and/or
The mass concentration of the sodium hydrogensulfite is 0.02 ~ 0.05wt%.
4. snore stopping liquid described according to claim 1 ~ any one of 3, which is characterized in that the sinapine, the 3- methoxy
The mass concentration ratio of base -4- hydroxycinnamic acid and the Senkyunolide A is 1:(0.1 ~ 0.5): (0.05 ~ 0.2).
5. snore stopping liquid according to claim 4, which is characterized in that the sinapine, the 3- methoxyl group -4- hydroxy cinnamate
The mass concentration ratio of the sour and described Senkyunolide A is 1:(0.2 ~ 0.3): (0.1 ~ 0.15).
6. snore stopping liquid described according to claim 1 ~ any one of 3, which is characterized in that the sinapine, laetrile
Mass concentration ratio is 1:0.2 ~ 0.4.
7. snore stopping liquid according to claim 6, which is characterized in that the sinapine, laetrile mass concentration ratio be
1:0.3.
8. snore stopping liquid described according to claim 1 ~ any one of 3, which is characterized in that the quality of the Tween-80, glycerol
Concentration ratio is 1:3 ~ 8.
9. the preparation method of snore stopping liquid described in a kind of any one of claim 1 ~ 8, which is characterized in that including following step
It is rapid:
(1) by sinapine, ferulic acid, Senkyunolide A, laetrile, tartaric acid and bisulfite
Sodium is dissolved in ionized water, obtains medical fluid A；
(2) medical charcoal is added in medical fluid A and stirs 20 ~ 40min, be then filtered removing medical charcoal, be subsequently added into tween-
80, glycerol, sodium chloride, edetate sodium, potassium sorbate and polyethylene glycol, obtain medical liquid B；
(3) medical liquid B is filtered with 0.2 ~ 0.5 μm of microporous barrier, then passes to nitrogen to nitrogen and be saturated, then in nitrogen
Filling and sealing is carried out in stream, obtains snore stopping liquid semi-finished product；
(4) sterilize snore stopping liquid semi-finished product 15 ~ 30min at 110 ~ 115 DEG C.
10. preparation method according to claim 7, which is characterized in that total dosage of the medical charcoal is the snore stopping liquid
0.05 ~ 0.15wt% of total weight.
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