CN110075937A - Pipettor gun head - Google Patents
Pipettor gun head Download PDFInfo
- Publication number
- CN110075937A CN110075937A CN201810078895.9A CN201810078895A CN110075937A CN 110075937 A CN110075937 A CN 110075937A CN 201810078895 A CN201810078895 A CN 201810078895A CN 110075937 A CN110075937 A CN 110075937A
- Authority
- CN
- China
- Prior art keywords
- pipettor
- active region
- internal diameter
- gun head
- transition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000007704 transition Effects 0.000 claims abstract description 52
- 239000007788 liquid Substances 0.000 claims abstract description 44
- 238000002474 experimental method Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 238000005842 biochemical reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
Abstract
The invention discloses a kind of pipettor gun heads, specifically, including pipette tips ontology, pipette tips ontology is integrated or integrally formed, and pipette tips ontology is tubulose, pipette tips ontology includes suction nozzle area, liquid storage area, transition region and pipettor active region from the bottom to top, and the inner cavity of the pipette tips ontology of tubulose is tapered configuration from top to bottom；The height in suction nozzle area is 7-10 mm, apex angle α, wherein 10 °≤α≤45 °, internal diameter is 0.4-0.9 mm；The height of liquid storage area is 30-35 mm, apex angle β, wherein 10 °≤β≤45 °, internal diameter is 0.8-1.8 mm；The height of transition region is 10-11 mm, and internal diameter is 1.8-5.4 mm；The height of pipettor active region is 5.4-5.8 mm, and internal diameter is 5.3-6.5 mm.Pipettor gun head of the invention, structure is simple, and range is moderate, and structural strength is high, and liquid relief precision is high, the small volume suitable for being widely present at present and high-throughput experiment.
Description
Technical field
The present invention relates to Bioexperiment clothing arts, relates more specifically to be suitable for high-throughput, small size and accuracy is high
Biochemical reaction a kind of small-range, high-precision pipettor gun head.
Background technique
With the rapid development of scientific and technical research, more and more high throughputs are tested in biological scientific research, medicament research and development, are divided
The fields such as analysis chemistry and clinical diagnosis are widely used.Manual mode of operation is no longer satisfied at high-throughput sample
Manage required in the process high efficiency, accuracy and safety, part or overall process automatic operating in experimental implementation process
Have become inexorable trend, more and more liquid working stations are developed and apply.In life science and medicament research and development
Equal fields, with the limitation of the factors such as the raising of the detecting instrument sensitivity used and sample preparation difficulty, small size it is anti-
System and component is answered more and more to be applied, such as the reaction system of microlitre (μ L) grade and micro updating small component below are built
It is vertical.Small size reaction system means to propose higher liquid relief required precision to the high-throughput liquid working station used, and makes
The design and quality of pipettor gun head are most important for the raising of liquid relief precision.Many liquid working stations use at present
The range of pipettor gun head is larger, and precision is lower, such as the pipette tips of 100 common μ L, and liquid relief precision is 2 μ L；The pipette tips of 50 μ L are moved
Liquid precision is 1 μ L；Or precision is suitable, but range is smaller, such as pipette tips of 10 μ L, liquid relief precision is 0.2 μ L；This kind of pipettor gun head
It is difficult to be suitable for high-throughput at present, small volume and high-precision biochemical reaction demand, therefore, this field is badly in need of developing one kind
The pipettor gun head that range is medium but liquid relief precision is high, can be compatible with liquid working station used at present.
Summary of the invention
The purpose of the present invention is to provide a kind of pipettor gun head, pipettor gun header structure of the invention is simple, and range is suitable
In, structural strength is high, and liquid relief precision is high, the small volume suitable for being widely present at present and high-throughput experiment.
The present invention provides a kind of pipettor gun heads, and specifically, including pipette tips ontology, the pipette tips ontology are integrated or one
It is molding, and the pipette tips ontology is tubulose, the pipette tips ontology includes suction nozzle area, liquid storage area, transition region and shifting from the bottom to top
The inner cavity of liquid device active region, the pipette tips ontology of tubulose is tapered configuration from top to bottom；The height in the suction nozzle area is 7-10
Mm, apex angle α, wherein 1 °≤α≤30 °, internal diameter is 0.4-0.9 mm；The height of the liquid storage area is 30-35 mm, apex angle
For β, wherein 1 °≤β≤30 °, internal diameter is 0.8-1.8 mm；The height of the transition region is 10-11 mm, internal diameter 1.8-
5.4 mm；The height of the pipettor active region is 5.4-5.8 mm, and internal diameter is 5.3-6.5 mm.
It should be noted that since the inner cavity of pipettor gun head of the invention is tapered configuration under upper, no
Inner cavity with section forms truncated cone-shaped space, and the cone-apex angle which corresponds to cone is exactly " top of the present invention
Angle ".
In another preferred example, the suction nozzle area is connected with the liquid storage area, the liquid storage area and the transition region phase
Connection, the transition region are connected to the pipettor active region.
In another preferred example, α=β.
In another preferred example, the periphery of the transition region is uniformly arranged multiple first protrusions.
In another preferred example, the quantity of first protrusion is 4-12.
In another preferred example, the transition region includes First Transition area and the second transition region, wherein the First Transition
Area is fixedly connected with the liquid storage area, and second transition region is fixedly connected with the pipettor active region.
In another preferred example, the internal diameter in the First Transition area is the 1/3-2/3 of the second transition region internal diameter.
In another preferred example, the internal diameter in the First Transition area is the 2/5 of the second transition region internal diameter.
In another preferred example, middle transition section is equipped between the First Transition area and second transition region.
In another preferred example, the multiple first protrusion is uniformly arranged on the periphery of the middle transition section.
In another preferred example, the periphery of the pipettor active region is uniformly arranged multiple second protrusions.
In another preferred example, the quantity of second protrusion is 4-12.
In another preferred example, the pipettor active region includes the first active region and the second active region, wherein described the
One active region is fixedly connected with the transition region, and second active region is fixedly connected with first active region.
In another preferred example, the internal diameter of first active region is bigger than the internal diameter of second active region by 0.5-1.5
mm。
In another preferred example, the multiple second protrusion is uniformly arranged on the periphery of second active region.
In another preferred example, the inner cavity of the pipettor active region and existing conventional the pipettor removably company of adaptation
It connects.
In another preferred example, the range of the pipettor gun head is 20-40 μ L；Preferably, 30 μ L.
In another preferred example, the liquid relief precision of the pipettor gun head is 0.3-0.8 μ L；Preferably, 0.5 μ L.
In another preferred example, the pipette tips are plastics pipette tips.
In another preferred example, the pipette tips are polypropylene pipette tips.
In another preferred example, it is equipped with scale marker in the outer surface of the pipette tips, reads the pipette tips institute convenient for operator
The approximate volume of the prepare liquid of absorption.
In another preferred example, the suction nozzle area, the liquid storage area, the transition region and the pipettor active region are same
Axis setting.
Main advantages of the present invention include:
(a) pipettor gun head range is small, liquid relief precision is high；
(b) especially suitable for high-throughput, small size reaction system；
(c) structure is simple, elegant in shape；
(d) pipettor active region can be compatible with the pipettor at high-throughput liquid working station of current mainstream, does not need to set again
New liquid working station is counted and built, reduces cost, and easy to spread.
It should be understood that above-mentioned each technical characteristic of the invention and specifically being retouched in below (eg embodiment) within the scope of the present invention
It can be combined with each other between each technical characteristic stated, to form a new or preferred technical solution.As space is limited, herein not
Tire out one by one again and states.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to do simply to introduce, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Fig. 1 is the cross-sectional view of the pipettor gun head in an example of the invention.
Fig. 2 is the main view of the pipettor gun head in an example of the invention.
Fig. 3 is the bottom view of the pipettor gun head in an example of the invention.
Fig. 4 is the perspective view of the pipettor gun head in an example of the invention.
In each attached drawing, each mark is as follows:
1- suction nozzle area；
2- liquid storage area；
3- transition region；
4- pipettor active region；
31- First Transition area；
The second transition region of 32-；
The first protrusion of 33-；
The first active region 41-；
The second active region 42-；
The second protrusion of 43-.
Specific embodiment
The present inventor after extensive and in-depth study, by largely screening, develops a kind of pipettor gun head for the first time, with
The prior art is compared, and pipettor gun head of the invention is particularly suitable for small volume and high-throughput experiment, and structure is simple, and is tied
Structure intensity is high, and range is moderate, and liquid relief precision is high, and by taking range is this pipette tips of 30 μ L as an example, liquid relief precision is 0.5 μ L, herein
On the basis of complete the present invention.
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, attached drawing is schematic diagram, therefore apparatus of the present invention and equipment are not shown by described
The size or ratio of intention limit.
It should be noted that in the claim and specification of this patent, such as first and second or the like relationship
Term is only used to distinguish one entity or operation from another entity or operation, without necessarily requiring or implying
There are any actual relationship or orders between these entities or operation.Moreover, the terms "include", "comprise" or its
Any other variant is intended to non-exclusive inclusion so that include the process, methods of a series of elements, article or
Equipment not only includes those elements, but also including other elements that are not explicitly listed, or further include for this process,
Method, article or the intrinsic element of equipment.In the absence of more restrictions, being wanted by what sentence " including one " limited
Element, it is not excluded that there is also other identical elements in the process, method, article or apparatus that includes the element.
Embodiment
The present invention provides pipettor gun heads, it is a kind of pipettor gun head with specific structure.
The pipettor gun head of the present embodiment is as shown in Figs 1-4.The pipettor gun head of the present embodiment includes pipette tips ontology, the rifle
Head ontology includes suction nozzle area (1), liquid storage area (2), transition region (3), pipettor active region (4), the pipette tips ontology one from the bottom to top
It is body formed to form.
Suction nozzle area (1) is tubulose, is connected with liquid storage area (2), and the internal diameter of suction nozzle area (1) is 0.4 mm -0.9 mm, with
Meet high liquid relief required precision, the apex angle α of the inner cavity of suction nozzle area (1) is 1-30 °.Liquid storage area (2) is connected with transition region (3),
Its internal diameter is from top to bottom gradually reduced, and the apex angle ss of the inner cavity of liquid storage area (2) is identical with α angular dimension.Transition region (3) and shifting
Liquid device active region (4) connection, including First Transition area (31) and the second transition region (32), the internal diameter of First Transition area (31) is than the
Two transition regions (32) are small, and transition region (3) can reduce the probability that liquid enters pipettor, prevent cross contamination, protect pipettor,
It is equipped with 8 first raised (33) between First Transition area (31) and the second transition region (32), pipette tips of the invention is facilitated to be placed in
In pipette tips box.Pipettor active region (4) include the first active region (41) and the second active region (42), the first active region (41) it is interior
Diameter is more bigger than the internal diameter of the second active region (42), and the internal diameter of the second active region (42) is more bigger than the internal diameter of transition region (3), and second makees
6 second raised (43) are equipped with the outer wall of area (42), pipettor active region (4) can be compatible with existing pipettor, simultaneously
Mechanical support is provided when inserting and take arms for automated fluid work station pipettor, is protected liquid storage area (2) and suction nozzle area (1).
The internal diameter of pipette tips ontology is gradually increased from the bottom to top.The internal diameter of liquid storage area (2) is 0.8 mm-1.8 mm.The
The internal diameter of one transition region (31) is the 1/3-2/3 of the second transition region (32) internal diameter, preferably 2/5.First active region (41) it is interior
Diameter is 0.5 mm-1.5 mm bigger than the internal diameter of the second active region (42).Pipette tips of the invention are made of plastic material, preferably by gathering
Propylene is made.
For pipettor gun head of the invention by industrial design, setting range is 30 μ L, and liquid relief precision is 0.5 μ L, is suitable for
The reaction system of small size, high-precision and high throughput.It, can be with the height of current mainstream and by the design to pipettor active region
The pipettor at flux liquid working station is compatible, does not need to redesign and build new liquid working station, reduces cost, and be easy to
It promotes.
All references mentioned in the present invention is incorporated herein by reference, and is individually recited just as each document
As with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can be right
The present invention makes various changes or modifications, and these equivalent forms also fall within the scope of the appended claims of the present application.
Claims (10)
1. a kind of pipettor gun head, which is characterized in that including pipette tips ontology, the pipette tips ontology is integrated or is integrally formed
, and the pipette tips ontology is tubulose, the pipette tips ontology includes suction nozzle area, liquid storage area, transition region and pipettor from the bottom to top
The inner cavity of active region, the pipette tips ontology of tubulose is tapered configuration from top to bottom；
The height in the suction nozzle area is 7-10 mm, apex angle α, wherein 1 °≤α≤30 °, internal diameter is 0.4-0.9 mm；
The height of the liquid storage area is 30-35 mm, apex angle β, wherein 1 °≤β≤30 °, internal diameter is 0.8-1.8 mm；
The height of the transition region is 10-11 mm, and internal diameter is 1.8-5.4 mm；
The height of the pipettor active region is 5.4-5.8 mm, and internal diameter is 5.3-6.5 mm.
2. pipettor gun head according to claim 1, which is characterized in that α=β.
3. pipettor gun head according to claim 1, which is characterized in that the periphery of the transition region is uniformly arranged multiple
One protrusion.
4. pipettor gun head according to claim 3, which is characterized in that the transition region includes First Transition area and second
Transition region, wherein the First Transition area is fixedly connected with the liquid storage area, and second transition region and the pipettor act on
Area is fixedly connected.
5. pipettor gun head according to claim 4, which is characterized in that the internal diameter in the First Transition area is described second
The 1/3-2/3 of transition region internal diameter.
6. pipettor gun head according to claim 4, which is characterized in that in the First Transition area and second transition
Middle transition section is equipped between area.
7. pipettor gun head according to claim 1, which is characterized in that the periphery of the pipettor active region is uniformly arranged
Multiple second protrusions.
8. pipettor gun head according to claim 7, which is characterized in that the pipettor active region includes the first active region
With the second active region, wherein first active region is fixedly connected with the transition region, second active region and described first
Active region is fixedly connected.
9. pipettor gun head according to claim 8, which is characterized in that the internal diameter of first active region is than described
Big 0.5-1.5 mm of the internal diameter of two active regions.
10. pipettor gun head according to claim 8, which is characterized in that the multiple second protrusion is uniformly arranged on institute
On the periphery for stating the second active region.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810078895.9A CN110075937A (en) | 2018-01-26 | 2018-01-26 | Pipettor gun head |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810078895.9A CN110075937A (en) | 2018-01-26 | 2018-01-26 | Pipettor gun head |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110075937A true CN110075937A (en) | 2019-08-02 |
Family
ID=67412638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810078895.9A Pending CN110075937A (en) | 2018-01-26 | 2018-01-26 | Pipettor gun head |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110075937A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069865A (en) * | 2006-03-31 | 2007-11-14 | 希森美康株式会社 | Pipette tip |
| CN101502811A (en) * | 2008-02-08 | 2009-08-12 | 富士胶片株式会社 | Pipette tip |
| CN204093472U (en) * | 2014-10-15 | 2015-01-14 | 浙江硕华医用塑料有限公司 | Disposable liquid transfer gun head |
| CN205269695U (en) * | 2015-12-24 | 2016-06-01 | 上海儒克生物科技有限公司 | Suction head pipettor |
| CN207913815U (en) * | 2018-01-26 | 2018-09-28 | 康码（上海）生物科技有限公司 | Pipettor gun head |
-
2018
- 2018-01-26 CN CN201810078895.9A patent/CN110075937A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069865A (en) * | 2006-03-31 | 2007-11-14 | 希森美康株式会社 | Pipette tip |
| CN101502811A (en) * | 2008-02-08 | 2009-08-12 | 富士胶片株式会社 | Pipette tip |
| CN204093472U (en) * | 2014-10-15 | 2015-01-14 | 浙江硕华医用塑料有限公司 | Disposable liquid transfer gun head |
| CN205269695U (en) * | 2015-12-24 | 2016-06-01 | 上海儒克生物科技有限公司 | Suction head pipettor |
| CN207913815U (en) * | 2018-01-26 | 2018-09-28 | 康码（上海）生物科技有限公司 | Pipettor gun head |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: Building No. 12, 118 Lane, Furong Hualu, Pudong New Area, Shanghai, 201321 Applicant after: Kang code (Shanghai) Biological Technology Co., Ltd. Address before: 3rd Floor, No. 8 Building, 500 Lane, Furong Hualu, Pudong New Area, Shanghai, 201321 Applicant before: Kang code (Shanghai) Biological Technology Co., Ltd. |
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| CB02 | Change of applicant information |