CN110072865A - 吡咯并芳杂环类化合物及其制备方法和医药用途 - Google Patents

吡咯并芳杂环类化合物及其制备方法和医药用途 Download PDF

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Publication number
CN110072865A
CN110072865A CN201780076186.0A CN201780076186A CN110072865A CN 110072865 A CN110072865 A CN 110072865A CN 201780076186 A CN201780076186 A CN 201780076186A CN 110072865 A CN110072865 A CN 110072865A
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Prior art keywords
phenyl
alkyl
pyrrolo
pyrimidine
oxygen
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CN110072865B (zh
Inventor
殷惠军
闫旭
宗利斌
田卫学
郑礼
窦浩帅
杨琰
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National Institutes of Pharmaceutical R&D Co Ltd
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National Institutes of Pharmaceutical R&D Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

本发明涉及吡咯并芳杂环类化合物及其制备方法和医药用途。特别地，本发明涉及通式I所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为BTK激酶抑制剂的用途，该化合物及其含有该化合物的药物组合物可以用于治疗与BTK激酶活性相关的疾病，例如炎症、自身免疫性病症、癌症等。其中通式I中的各取代基的定义与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (16)

  1. PCT国内申请，权利要求书已公开。
CN201780076186.0A 2017-02-08 2017-12-26 吡咯并芳杂环类化合物及其制备方法和医药用途 Active CN110072865B (zh)

Applications Claiming Priority (3)

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CN201710068798 2017-02-08
CN2017100687987 2017-02-08
PCT/CN2017/118424 WO2018145525A1 (zh) 2017-02-08 2017-12-26 吡咯并芳杂环类化合物及其制备方法和医药用途

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US (1) US11608334B2 (zh)
EP (1) EP3556761B1 (zh)
JP (1) JP7164203B2 (zh)
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AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN112812117B (zh) * 2019-11-18 2023-12-22 中国医药研究开发中心有限公司 一种btk抑制剂的新晶型及其制备方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy

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Patent Citations (4)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021037188A1 (zh) * 2019-08-29 2021-03-04 中国科学院上海药物研究所 嘧啶并[5,4-b]吡呤化合物的制药用途

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JP2020509999A (ja) 2020-04-02
EP3556761A1 (en) 2019-10-23
JP7164203B2 (ja) 2022-11-01
EP3556761A4 (en) 2019-12-25
CN110072865B (zh) 2022-02-11
US11608334B2 (en) 2023-03-21
US20200062749A1 (en) 2020-02-27
WO2018145525A1 (zh) 2018-08-16
EP3556761B1 (en) 2021-03-03

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