CN110064014A - A kind of ointment for removing obstruction in meridians and preparation method thereof - Google Patents
A kind of ointment for removing obstruction in meridians and preparation method thereof Download PDFInfo
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- CN110064014A CN110064014A CN201910474244.6A CN201910474244A CN110064014A CN 110064014 A CN110064014 A CN 110064014A CN 201910474244 A CN201910474244 A CN 201910474244A CN 110064014 A CN110064014 A CN 110064014A
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Abstract
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of ointment for removing obstruction in meridians and preparation method thereof.The ointment for removing obstruction in meridians includes the following raw material composition: arisacma consanguineum schott, Rhizoma Chuanxiong, Radix Aconiti, white pepper, Radix Aconiti Kusnezoffii, cortex cinnamomi, vomiting nut, Chinese ephedra, unprocessed Radix Aconiti Lateralis, radix saposhnikoviae, asarum, the root of Dahurain angelica, Radix Angelicae Sinensis, rhizoma atractylodis, cloves, Bi Collettii, Eupolyphoge sinensis, full worm, centipede, olibanum, myrrh, semen momordicae, Moschus, asafoetide, the dried venom of toads, dragon's blood, rhizoma homalonemae, ginger, bush, radix achyranthis bidentatae.The invention further relates to the preparation methods of ointment for removing obstruction in meridians, the polysaccharide in medicinal material can be made to decompose using the fermentation of mixed enzyme enzymatic yeast bacterium, and further degrade to the cell of medicinal material, promote intracellular effective component to ooze out, improve the utilization rate and utility value of medicinal material.It is high, at low cost that the present invention prepares ointment for removing obstruction in meridians active constituent utilization rate height, curative effect, and can effectively cure a variety of orthopaedics class diseases.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of ointment for removing obstruction in meridians and preparation method thereof.
Background technique
Plaster, one kind of Chinese medicine external, ancient name is thin paste are boiled into colloid substance with vegetable oil or animal oil dosing, be coated in cloth,
The one side of paper or skin can be attached to affected part for a long time, be mainly used to treat boil, detumescence pain etc..As early as in ancient times,
China physician it had a saying that: " plaster can cure the disease, and no special medicine is with the right method, and it has immediate effect."
Plaster is one of common outer treating method of tcm clinical practice through the skin emplastrum medication that plays a role, it follows Chinese medical discrimination opinion
Control and the effect of Chinese medicine, cure mainly principle with channel tropism, give full play to drug coordinate mutually for efficiency, form multi-flavor drug
Compound, to play the good result of drug.Since plaster is directly applied to body surface, and the most smell of drug for making paste compared with
It is dense, it adds Xin Xiang and walks to alter extremely strong tying-in drug, by infiltrating through skin, interior transmission from one channel to another network, internal organs play regulating the qi flowing in the channels blood, promoting menstruation
The effects of network, cold dispelling are wet, pain of reducing swelling.
According to modern pharmacological research, ointment for removing obstruction in meridians is better than rubber paste in terms of absorption, curative effect.But due to ointment for removing obstruction in meridians
Manufacture craft is complex, does not seek unity of standard, and is not easy to carry out quality control, causes the quality of ointment for removing obstruction in meridians irregular neat.Cause
The production of ointment for removing obstruction in meridians is time-consuming and laborious, and the hospital of traditional Chinese hospital carries out the external application of Chinese medicine more, i.e., honey, all scholars are called in after being crushed with Chinese herbal medicine
The matrix such as woods are fixed after being applied in ointment shape with cotton paper, bandage, every dressing in 24 hours time, higher operating costs.Ointment for removing obstruction in meridians
Every patch can be used 3-15 days, can stick, not affected the treatment again after taking off, therefore expense is lower.
The diseases such as various rheumatism, rheumatoid arthritis, scapulohumeral periarthritis scapulohumeral periarthritis, cervical spondylosis, protrusion of lumber intervertebral disc are treated at present
Shape mostly uses and takes the drugs respite pain such as decoction of medicinal ingredients, parenterally rice, also has using manual massage, partial closure's method, but these
Therapeutic effect cannot completely remove old complaint, so that patient is decocted the torment by disease black mole for a long time, while also to adhere to taking medicine, bring to patient
Great financial burden.
Application No. is the Chinese invention patents of CN201510122239 to disclose a kind of Chinese medicine for treating cervical vertebra disease
Composition and plaster are by pangolin, lopseed, river Chinese herbaceous peony, Radix Angelicae Pubescentis, the root of Dahurain angelica, asarum, Paris polyphylla, pawpaw, rhizoma atractylodis, pueraria lobata, borneol, toad
Clothing, toad skin, the tuber of pinellia, rhizoma arisaematis, monkshood, radix aconiti agrestis, the fruit of summer cypress, kuh-seng, Chinese prickly ash, Radix Glycyrrhizae, bald duck, ginger, full worm, honeycomb composition.
Application No. is the Chinese invention patents of CN201410628513 to disclose a kind of Chinese medicine group for treating rheumatism, orthopaedics disease
Close object plaster, by being formulated: radix saposhnikoviae, schizonepeta, Fructus Forsythiae, radix paeoniae rubra, angelica tail 14 1 16, safflower, Huang slight, Cortex Phellodendri, bombyx batryticatus, Radix Glycyrrhizae,
The rhizome of davallia, worm move back, rheum officinale, honeysuckle flower, joy clam, monkshood, radix aconiti agrestis, Radix Angelicae Pubescentis, rhizoma atractylodis, asarum, Qin Yuan, olibanum, myrrh, the tuber of multiflower knotweed, cnidium monnieri
Son, semen momordicae, big maple, camphor, borneol, yellow lead composition.The present invention by scientific compatibility, reach the promoting flow of qi and blood circulation, it is broken become silted up dissipate it is stagnant
The effects of.
But rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, lumbar vertebrae can thoroughly be treated currently on the market by not having but
The Chinese medicine ointment of the old complaints of illnesss such as disk drug scapulohumeral periarthritis outstanding, and can also be recurred after treating, and Western medicine expenses for medicine is expensive, and
It is palliative.And Chinese medicine ointment active constituent utilization rate is low at present, weak curative effect.
Summary of the invention
For overcome the deficiencies in the prior art, it enables the patient to get rid of rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical vertebra
The diseases such as disease, protrusion of lumber intervertebral disc scapulohumeral periarthritis, the present invention provide that a kind of active constituent utilization rate is high, curative effect is high, medicine at low cost
Object, the drug can effectively cure a variety of orthopaedics class diseases.
A kind of ointment for removing obstruction in meridians, the raw material including following parts by weight:
5-10 parts of arisacma consanguineum schott, 5-10 parts of Rhizoma Chuanxiong, 5-10 parts of Radix Aconiti, 5-10 parts of white pepper, 5-10 parts of Radix Aconiti Kusnezoffii, cortex cinnamomi 5-10
Part, 5-10 parts of vomiting nut, 5-10 parts of Chinese ephedra, 5-10 parts of unprocessed Radix Aconiti Lateralis, 5-10 parts of radix saposhnikoviae, 5-10 parts of asarum, 5-10 parts of the root of Dahurain angelica, Radix Angelicae Sinensis
5-10 parts, 5-10 parts of rhizoma atractylodis, 5-10 parts of, Bi Collettii of 5-10 parts of cloves, 5-10 parts of Eupolyphoge sinensis, worm 5-10 parts complete, 5-10 parts of centipede, olibanum
5-10 parts, 5-10 parts of myrrh, 5-10 parts of semen momordicae, 0.1-0.8 parts of Moschus.
In above scheme preferably, the ointment for removing obstruction in meridians further comprises the raw material of following parts by weight: asafoetide 5-
10 parts, 5-10 parts of the dried venom of toads, 5-10 parts of dragon's blood, 5-10 parts of rhizoma homalonemae, 5-10 parts of ginger, 5-10 parts of bush, 5-10 parts of radix achyranthis bidentatae.
A kind of preparation method of ointment for removing obstruction in meridians, the ointment for removing obstruction in meridians include the raw material of following parts by weight: arisacma consanguineum schott
1-5 parts, 1-5 parts of Rhizoma Chuanxiong, 1-5 parts of Radix Aconiti, 1-5 parts of white pepper, 1-5 parts of Radix Aconiti Kusnezoffii, 1-5 parts of cortex cinnamomi, 1-5 parts of vomiting nut, fiber crops
5-10 parts yellow, 1-5 parts of unprocessed Radix Aconiti Lateralis, 1-5 parts of radix saposhnikoviae, 1-5 parts of asarum, 1-5 parts of the root of Dahurain angelica, 1-5 parts of Radix Angelicae Sinensis, 1-5 parts of rhizoma atractylodis, cloves 1-
5 parts of 1-5 parts of, Bi Collettiis, 1-5 parts of Eupolyphoge sinensis, worm 1-5 parts complete, 1-5 parts of centipede, 1-5 parts of semen momordicae, 0.1-0.3 parts of Moschus, asafoetide 5-
10 parts, 5-10 parts of the dried venom of toads, 5-10 parts of dragon's blood, 5-10 parts of rhizoma homalonemae, 5-10 parts of ginger, 5-10 parts of bush, 5-10 parts of radix achyranthis bidentatae;
(1) raw material is weighed by above-mentioned parts by weight, crushed, the 3-5 times of water measured is added, be added by amylase, cellulase, pectase
The mixed enzyme of composition obtains Chinese medicine mixed liquor in 26-32 DEG C of ultrasonic vibration, enzymatic hydrolysis 2-4 h;
(2) saccharomycete of Chinese medicine material weight 1-3%, the withered grass bar of 0.5-1% are added into step (1) resulting Chinese medicine mixed liquor
Bacterium is warming up to 100 DEG C of 10 min sterilizing in 33-37 DEG C of fermentation 24-36 h;
(3) Chinese medicine mixed liquor for obtaining step (2) decocts 3-6 h, is concentrated into thick;
(4) 2-4 times of the Chinese medicine sesame oil measured is added into step (3) resulting sticky mass, is then heated to 120 DEG C -180
DEG C, it endures at the shrivelled color of Chinese medicine, boiling the time is 2-6 hours, and ointment for removing obstruction in meridians is made.
The usage of ointment for removing obstruction in meridians in the present invention: it is affixed on sore spot with fire roastingization, changes within 2-3 days points for attention: Yun Fuji
Skin allergy person disabling.Prepared by the present invention contains amylase, cellulase, pectase in mixed enzyme used in plaster process,
The cell wall of Chinese medicine material can be decomposed, intracellular effective component is made to be easy to leach, Chinese medicine material effective substance can be improved
The leaching of matter.Hay bacillus, saccharomycete can be such that the polysaccharide in medicinal material decomposes in fermentation process, and further to the cell of medicinal material into
Row degradation, promotes intracellular effective component to ooze out, improves the utilization rate and utility value of medicinal material.
Ointment active constituent utilization rate height in the present invention, curative effect are high, at low cost, and permeability is strong, is absorbed into through skin
The effects of tissue plays clearing and activating the channels and collaterals, anti-inflammatory analgetic, and softening hardness and resolving stasis promotes blood circulation, tissue function regeneration;And energy
Cure a variety of orthopaedics class diseases such as rheumatism, rheumatoid arthritis, scapulohumeral periarthritis, cervical spondylosis, protrusion of lumber intervertebral disc.
The pharmacology and nature,taste and action of part Chinese medicine used in the present invention:
Arisacma consanguineum schott: bitter, pungent, warm, toxic, return lung, liver, the spleen channel.Effect: 1. eliminating dampness and eliminating phlegm: this product is eliminating dampness and eliminating phlegm function is like half
More very, eliminating the phlegm is stronger for summer and the property of temperate-dryness;For damp phlegm, cold-phlegm syndrome;Control damp phlegm resistance lung, cough and phlegm, chest and diaphragm expire vexed, Chang Yuban
Summer mutually must be used, and the compatibility dried immature fruit of citron orange, Exocarpium Citri Rubrum are equally used.2. expelling endogenous wind to relieve convulsion: this product specially walks channels and collaterals, is apt to wind-dispelling phlegm and relieving convulsion;For
Wind-phlegm syndrome, such as dizziness, apoplexy, epilepsy are sick, mouth eye is oblique and tetanus.Control wind phlegm retention channels and collaterals, hemiplegia, the stupid fiber crops of brothers, mouth
Eye tiltedly etc., can the compatibility tuber of pinellia, monkshood, rhizoma typhonii etc..3. external application mass dissipating and swelling eliminating: this product external application has the function of dispersing swelling and dissipating binds analgesic.With
In ulcer sore pain, venomous snake bite etc..
Rhizoma Chuanxiong: the pungent scattered temperature of Rhizoma Chuanxiong is logical, function promoting blood circulation, and effect extensively, is suitable for the illness of various stagnation of blood stasis, especially
Fuke Tiaojing key medicine.Irregular menstruation, menostasis, dysmenorrhea are controlled, often with medicines such as Radix Angelicae Sinensis with use;Pain in chest and hypochondrium is controlled, it can be with radix bupleuri, rhizoma cyperi etc.
With use;Rheumatic arthralgia is controlled, can equally be used with Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis;Abdominal mass caking is controlled, can equally be used with trigone, curcuma zedoary;It is swollen to control sore
Bitterly, traumatic injury can equally be used with olibanum, myrrh.
Unprocessed Radix Aconiti Lateralis: meridian distribution of property and flavor, pungent, sweet, the big heat of nature and flavor is toxic, belongs to the heart, kidney, spleen channel.Major function: recuperating depleted yang, temperature
Kidney is supporing yang, eliminating cold to stop pain.For yang depletion collapse card, all cards of the deficiency of yang, arthritis with fixed pain caused by dampness, severe and wadering arthralgia, whole body arthralgia, waist weight crymodynia, carbuncle
Subcutaneous ulcer is bitterly swollen etc..
Radix Aconiti: it is pungent, bitter, hot, it is very toxic.Return heart, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.It is wet for chill
Numbness, arthralgia, trusted subordinate's crymodynia, cold hernia are had a pain.For treating the illnesss such as wind-cold-dampness arthralgia, arthralgia.It is taken orally after general processing.
The external application of Radix Aconiti tincture can stimulate skin, then generate feeling of numbness, therefore be used as the analgestic of certain neuralgias and rheumatism outside.
Radix Angelicae Sinensis: it is sweet in flavor, pungent, bitter, it is warm-natured.The all cards of the deficiency of blood: irregular menstruation, menostasis, dysmenorrhea, abdominal mass knot is poly-, metrorrhagia and metrostaxis, cold of insufficiency type abdomen
Bitterly, flaccidity syndrome and arthralgia syndrome, numbness, intestines are dry and shit is difficult, it is red catch after weight, ulcer sores, injury from falling down.
Ginger: warm-natured, distinctive " gingerol " energy stimulating gastrointestinal mucous membrane makes gastrointestinal redness, digestion power enhancing, energy
Effectively treat eat cold and cool food it is excessive caused by abdominal distension, abdominal pain, diarrhea, vomiting etc., after eating ginger, people has body hair
The feeling of heat, this is because it can distend the blood vessels, blood circulation is accelerated, promote with pore open, so not only can be
The extra torrid zone is walked, while also intracorporal germ, cold air are taken out of together.When body has eaten cold and cool object, drenched with rain or
It is stayed in air-conditioned room long afterwards, various discomforts caused by eating ginger and capable of eliminating in time because of the cold weight of human body.
Moschus: the secretion of the glandular sac between the navel and genitals of male musk deer is in granular form or blocky after dry, there is spy
Different fragrance, there is bitter taste, and fragrance can be made, and can also be used as medicine, and is central nervous excitation agent, and external application can ease pain, disappear midship, be used for
Blood stasis, micro- lump in the abdomen, trusted subordinate sudden and violent pain, traumatic injury, the card such as wind-cold-dampness arthralgia;Product Xin Xiang, opens away and alters, can mark in promoting circulation of blood
Stagnant, the Wei for opening channels and collaterals holds back, and with the handsome poison of promoting menstruation eliminating stagnation to stop pain river fourth sore, throat general's harmony, the pungent fragrant row of the crystalline substance dissipates, and has good promoting blood circulation
There is good effect in dissipating bind, swelling and pain relieving effect, river for oral administration, outer.
Olibanum: warm-natured, acrid flavour, hardship.Thoughts of returning home warp, the spleen channel, Liver Channel.Have effects that regulating qi and activating blood, analgesic therapy, detumescence, myogenic.
Belong to the blood-activating analgesic classified under drug for invigorating blood circulation and eliminating stasis.
Myrrh: bitter, pungent, flat.Enter the heart, liver,spleen,kidney four passes through.Effect: dissipating blood and dissolving stasis, and the pungent scattered hardship of myrrh is let out, and enters blood
Point, there is the function of scattered blood and dissolving stasis, swelling and pain relieving.Compendium of Material Medica day its: " dissipate blood detumescence, analgesic therapy myogenic." therefore be usually used in wound and swell
Bitterly, metal-inflicted wound cane Shang, lumps in the chest and abdomen.
Specific embodiment
In order to further appreciate that the present invention, technical solution of the present invention is illustrated in more detail below with reference to example, is implemented
Example is only exemplary effect to the ointment for removing obstruction in meridians and preparation method thereof in the present invention, acts on without any restrictions,
Any and identical technical solution of substance of the invention, the category scope of the present invention.
The preparation of 1 ointment for removing obstruction in meridians of embodiment:
A kind of ointment for removing obstruction in meridians, the raw material (every 1g is 1 part) including following parts by weight: 5 parts of arisacma consanguineum schott, 5 parts of Rhizoma Chuanxiong, Radix Aconiti
5 parts, 5 parts of white pepper, 5 parts of Radix Aconiti Kusnezoffii, 5 parts of cortex cinnamomi, 5 parts of vomiting nut, 5 parts of Chinese ephedra, 5 parts of unprocessed Radix Aconiti Lateralis, radix saposhnikoviae 5 parts, 5 parts of asarum,
5 parts of the root of Dahurain angelica, 5 parts of Radix Angelicae Sinensis, 5 parts of rhizoma atractylodis, 5 parts of cloves, 5 parts of, Bi Collettii, 5 parts of Eupolyphoge sinensis, 5 parts of full worm, 5 parts of centipede, 5 parts of olibanum, myrrh 5
Part, 5 parts of semen momordicae, 0.2 part of Moschus, 5 parts of asafoetide, 5 parts of the dried venom of toads, 5 parts of dragon's blood, 5 parts of rhizoma homalonemae, 5 parts of ginger, 5 parts of bush, radix achyranthis bidentatae
5 parts;
Preparation method is as follows:
(1) raw material is weighed by above-mentioned parts by weight, crushed, the water of 3 times of amounts is added, be added by amylase, cellulase, pectase group
At mixed enzyme, 28 DEG C of ultrasonic vibrations, enzymatic hydrolysis 2 h, obtain Chinese medicine mixed liquor;
(2) saccharomycete of Chinese medicine material weight 2%, 1% hay bacillus are added into step (1) resulting Chinese medicine mixed liquor,
33 DEG C of fermentations for 24 hours, are warming up to 100 DEG C of 10 min sterilizing;
(3) Chinese medicine mixed liquor for obtaining step (2) decocts 3 h, is concentrated into thick;
(4) into step (3) resulting sticky mass be added 2 times of Chinese medicine amount sesame oil, be then heated to 120 DEG C, endure at
The shrivelled color of Chinese medicine, tanning time are 2 hours, and ointment for removing obstruction in meridians is made.
The preparation of 2 ointment for removing obstruction in meridians of embodiment.
A kind of ointment for removing obstruction in meridians, the raw material (every 1g is 1 part) including following parts by weight: 5 parts of arisacma consanguineum schott, 5 parts of Rhizoma Chuanxiong, life
5 parts of monkshood, 6 parts of white pepper, 6 parts of Radix Aconiti Kusnezoffii, 6 parts of cortex cinnamomi, 6 parts of vomiting nut, 6 parts of Chinese ephedra, 6 parts of unprocessed Radix Aconiti Lateralis, windproof 6 parts, asarum 6
Part, 6 parts of cloves, 6 parts of, Bi Collettii, 6 parts of Eupolyphoge sinensis, 6 parts of full worm, 6 parts of centipede, 6 parts of olibanum, does not have 6 parts of the root of Dahurain angelica, 6 parts of Radix Angelicae Sinensis, 6 parts of rhizoma atractylodis
5 parts of medicine, 5 parts of semen momordicae, 0.3 part of Moschus, 5 parts of asafoetide, 5 parts of the dried venom of toads, 6 parts of dragon's blood, 6 parts of rhizoma homalonemae, 6 parts of ginger, 5 parts of bush,
5 parts of radix achyranthis bidentatae;
Preparation method is as follows:
(1) raw material is weighed by above-mentioned parts by weight, crushed, the water of 4 times of amounts is added, be added by amylase, cellulase, pectase group
At mixed enzyme, 30 DEG C of ultrasonic vibrations, enzymatic hydrolysis 3 h, obtain Chinese medicine mixed liquor;
(2) saccharomycete of Chinese medicine material weight 2%, 1% hay bacillus are added into step (1) resulting Chinese medicine mixed liquor,
35 DEG C of fermentations for 24 hours, are warming up to 100 DEG C of 10 min sterilizing;
(3) Chinese medicine mixed liquor for obtaining step (2) decocts 5 h, is concentrated into thick;
(4) into step (3) resulting sticky mass be added 3 times of Chinese medicine amount sesame oil, be then heated to 150 DEG C, endure at
The shrivelled color of Chinese medicine, tanning time are 2 hours, and ointment for removing obstruction in meridians is made.
The preparation of 3 ointment for removing obstruction in meridians of embodiment.
A kind of ointment for removing obstruction in meridians, the raw material (every 1g be 1 part) including following parts by weight: 10 parts of arisacma consanguineum schott, 10 parts of Rhizoma Chuanxiong,
10 parts of Radix Aconiti, 10 parts of white pepper, 10 parts of Radix Aconiti Kusnezoffii, 10 parts of cortex cinnamomi, 10 parts of vomiting nut, 10 parts of Chinese ephedra, 10 parts of unprocessed Radix Aconiti Lateralis, radix saposhnikoviae
10 parts, 10 parts of asarum, 10 parts of the root of Dahurain angelica, 10 parts of Radix Angelicae Sinensis, 10 parts of rhizoma atractylodis, 10 parts of cloves, 10 parts of, Bi Collettii, 10 parts of Eupolyphoge sinensis, 10 parts of full worm,
10 parts of centipede, 10 parts of olibanum, 10 parts of myrrh, 7 parts of semen momordicae, 0.6 part of Moschus, 8 parts of asafoetide, 8 parts of the dried venom of toads, 8 parts of dragon's blood, rhizoma homalonemae
8 parts, 8 parts of ginger, 8 parts of bush, 8 parts of radix achyranthis bidentatae;
Preparation method is as follows:
(1) raw material is weighed by above-mentioned parts by weight, crushed, the water of 5 times of amounts is added, be added by amylase, cellulase, pectase group
At mixed enzyme, 32 DEG C of ultrasonic vibrations, enzymatic hydrolysis 4h, obtain Chinese medicine mixed liquor;
(2) saccharomycete of Chinese medicine material weight 21%, 0.5% hay bacillus are added into step (1) resulting Chinese medicine mixed liquor,
In 37 DEG C of fermentation 36h, it is warming up to 100 DEG C of 10 min sterilizing;
(3) Chinese medicine mixed liquor for obtaining step (2) decocts 6 h, is concentrated into thick;
(4) into step (3) resulting sticky mass be added 4 times of Chinese medicine amount sesame oil, be then heated to 180 DEG C, endure at
The shrivelled color of Chinese medicine, tanning time are 6 hours, and ointment for removing obstruction in meridians is made.
The present invention is prepared containing amylase, cellulase, pectase in mixed enzyme used in plaster process, being capable of centering
The cell wall of medicine raw material is decomposed, and intracellular effective component is made to be easy to leach, and the leaching of Chinese medicine material active principle can be improved.
Hay bacillus, saccharomycete can be such that the polysaccharide in medicinal material decomposes in fermentation process, and further degrade to the cell of medicinal material, promote
It is oozed out into intracellular effective component, improves the utilization rate and utility value of medicinal material.
4 zoopery of embodiment
Drug and reagent protrusion of lumber intervertebral disc patch are amendment medicine company production.The male mouse 30 of the health of 18-2g is taken, is randomly divided into three
Group, A group are ointment for removing obstruction in meridians group, and B group protrusion of lumber intervertebral disc patch (production of amendment medicine company), C group is vaseline control group.A group is given
The every ear of mouse is forced on 0.1 g of foam agent;B group pastes 0.1g to the every ear patch protrusion of lumber intervertebral disc of mouse;C group is blank control group,
0.1 g of vaseline is applied to the every ear of mouse.After administration 2 hours, drug is removed, in 0.05 ml of auris dextra melted paraxylene, left ear conduct pair
According to, 1 h after drop, then method is administered once by the above process, is removed residue after 3 hours, is dried, and lays ear with 0.3cm punch
Piece, weighing, is averaged, the results are shown in Table 1
Medicine name | Drug dose (g) | Swelling (mg) |
Ointment for removing obstruction in meridians group | 0.1 | 1.2 |
Protrusion of lumber intervertebral disc patch | 0.1 | 5.4 |
Vaseline group | 0.1 | 10.7 |
The result shows that ointment for removing obstruction in meridians group can preferably inhibit mouse auricular concha swelling caused by dimethylbenzene, and it is substantially better than city
The protrusion of lumber intervertebral disc patch sold.
5 actual clinical effect of embodiment
Case 1: Ma, female, Henan people from Xihua, cervical vertebra 6 years, on December 13rd, 2017 started medication, the 5th day periarthritis of shoulder joint
Pain, arm cannot select movable symptom and be obviously improved, and continuous use 30 days, all caused illnesss of all cervical vertebras all disappeared,
So far it does not recur again.
Case 2: Mr. Wang, male, Henan people from Xihua, the party of in 9Yue26Gan, 2018 right shoulder pain, the state of an illness even gradually aggravate, quilt
It is diagnosed as scapulohumeral periarthritis, gnawing pains take no rest recently, and weight lifting is difficult, cannot work, continuously be pasted more than 40 days with ointment for removing obstruction in meridians of the present invention, existing
Activity is freely.
Case 3: Zhang, female, Henan people from Shangshui, November in 2018 2 Gan party shoulder pain, dizziness, headache, left half body fiber crops
Wood, the state of an illness even gradually aggravate, and use ointment for removing obstruction in meridians of the present invention after being diagnosed as cervical spondylosis, symptom is obviously improved after 30 days, after 40 days
Cardinal symptom completely disappears, and does not send out so far.
Case 4: Mr. Li, female, Henan people from Dancheng, on March 10th, 2018, redness and swelling of joints, in great pain, and the state of an illness even gradually adds
Weight uses ointment for removing obstruction in meridians of the present invention after being diagnosed as rheumatoid arthritis, and symptom is obviously improved after 20 days, basic disease after 35 days
Shape completely disappears, and does not send out so far.
Case 5: place so-and-so, male, Henan people from Zhoukou City, it is prominent to be diagnosed as 4-5 lumber ertebral disc through X-ray inspection frequent pain in the loins
Out, in October, 2017 is introduced through others, takes book " dredging collateral analgesic extract " 14 now, is disappeared using low back pain symptom
It loses, protrasion of the lumbar intervertebral disci shape disappears after check.
Case 6: soup so-and-so, male, Henan people from Huaiyang suffers from cervical spondylosis for many years, and cervical pain is uncomfortable, the tingle discomfort in right side, warp
It is diagnosed as cervical vertebra hyperplasia in hospital, is disappeared with this " dredging collateral analgesic extract " 25, various pain and malaise symptoms within 2 months 2018.
Ointment curative effect in the present invention is high, at low cost, and permeability is strong, is absorbed into tissue through skin, plays promoting menstruation
The effects of active, anti-inflammatory analgetic, softening hardness and resolving stasis promotes blood circulation, tissue function regeneration;And rheumatism, rheumatoid can be cured
A variety of orthopaedics class diseases such as arthritis, scapulohumeral periarthritis, cervical spondylosis, protrusion of lumber intervertebral disc.
Claims (5)
1. a kind of ointment for removing obstruction in meridians, the raw material including following parts by weight: 5-10 parts of arisacma consanguineum schott, 5-10 parts of Rhizoma Chuanxiong, Radix Aconiti 5-
10 parts, 5-10 parts of white pepper, 5-10 parts of Radix Aconiti Kusnezoffii, 5-10 parts of cortex cinnamomi, 5-10 parts of vomiting nut, 5-10 parts of Chinese ephedra, unprocessed Radix Aconiti Lateralis 5-10
5-10 parts of part, 5-10 parts of radix saposhnikoviae, 5-10 parts of asarum, 5-10 parts of the root of Dahurain angelica, 5-10 parts of Radix Angelicae Sinensis, 5-10 parts of rhizoma atractylodis, cloves, Bi Collettii 5-10
Part, 5-10 parts of Eupolyphoge sinensis, worm 5-10 parts complete, 5-10 parts of centipede, 5-10 parts of olibanum, 5-10 parts of myrrh, 5-10 parts of semen momordicae, Moschus
0.1-0.8 parts.
2. ointment for removing obstruction in meridians as described in claim 1, which is characterized in that further include the raw material of following parts by weight: asafoetide 5-
10 parts, 5-10 parts of the dried venom of toads, 5-10 parts of dragon's blood, 5-10 parts of rhizoma homalonemae, 5-10 parts of ginger, 5-10 parts of bush, 5-10 parts of radix achyranthis bidentatae.
3. a kind of preparation method of ointment for removing obstruction in meridians, the raw material including following parts by weight: 5-10 parts of arisacma consanguineum schott, Rhizoma Chuanxiong 5-10
Part, 5-10 parts of Radix Aconiti, 5-10 parts of white pepper, 5-10 parts of Radix Aconiti Kusnezoffii, 5-10 parts of cortex cinnamomi, 5-10 parts of vomiting nut, 5-10 parts of Chinese ephedra,
5-10 parts of unprocessed Radix Aconiti Lateralis, 5-10 parts of radix saposhnikoviae, 5-10 parts of asarum, 5-10 parts of the root of Dahurain angelica, 5-10 parts of Radix Angelicae Sinensis, 5-10 parts of rhizoma atractylodis, cloves 5-10
Part 5-10 parts of, Bi Collettii, 5-10 parts of Eupolyphoge sinensis, worm 5-10 parts complete, 5-10 parts of centipede, 5-10 parts of olibanum, 5-10 parts of myrrh, semen momordicae 5-
10 parts, 0.1-0.8 parts of Moschus, 5-10 parts of asafoetide, 5-10 parts of the dried venom of toads, 5-10 parts of dragon's blood, 5-10 parts of rhizoma homalonemae, 5-10 parts of ginger,
5-10 parts of bush, 5-10 parts of radix achyranthis bidentatae, preparation method is as follows:
(1) raw material is weighed by above-mentioned parts by weight, crushed, the 3-5 times of water measured is added, be added by amylase, cellulase, pectase
The mixed enzyme of composition obtains Chinese medicine mixed liquor in 26-32 DEG C of ultrasonic vibration, enzymatic hydrolysis 2-4 h;
(2) saccharomycete of Chinese medicine material weight 1-3%, the withered grass bar of 0.5-1% are added into step (1) resulting Chinese medicine mixed liquor
Bacterium is warming up to 100 DEG C of 10 min sterilizing in 33-37 DEG C of fermentation 24-36 h;
(3) Chinese medicine mixed liquor for obtaining step (2) decocts 3-6 h, is concentrated into thick;
(4) 2-4 times of the Chinese medicine sesame oil measured is added into step (3) resulting sticky mass, is then heated to 120 DEG C -180
DEG C, it endures at the shrivelled color of Chinese medicine, boiling the time is 2-6 hours, and ointment for removing obstruction in meridians is made.
4. a kind of ointment for removing obstruction in meridians prepared by preparation method as claimed in claim 3.
5. the described in any item ointment for removing obstruction in meridians of claim 1-4 treat rheumatism, rheumatoid arthritis, scapulohumeral periarthritis shoulder in preparation
Zhou Yan, cervical spondylosis, protrusion of lumber intervertebral disc drug in application.
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CN103127345A (en) * | 2013-03-14 | 2013-06-05 | 吴小斌 | Plaster for treating rheumatism, arthralgia and myalgia and preparation method thereof |
CN103768567A (en) * | 2014-01-21 | 2014-05-07 | 张学记 | Black plaster and preparation method thereof |
CN107522767A (en) * | 2017-10-13 | 2017-12-29 | 陈增光 | A kind of preparation method of turmeric saponin |
CN108567829A (en) * | 2018-06-04 | 2018-09-25 | 刘海军 | A kind of Chinese medicine and preparation method thereof for treating rheumatism osteoarthropathy |
CN109331109A (en) * | 2018-11-30 | 2019-02-15 | 张明 | A kind of Chinese medicine composition and preparation method thereof for treating neck-shoulder pain, lumbago and leg pain |
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CN1332005A (en) * | 2001-07-12 | 2002-01-23 | 明朝钢 | Meridian dredging and pain relieving ointment |
CN103127345A (en) * | 2013-03-14 | 2013-06-05 | 吴小斌 | Plaster for treating rheumatism, arthralgia and myalgia and preparation method thereof |
CN103768567A (en) * | 2014-01-21 | 2014-05-07 | 张学记 | Black plaster and preparation method thereof |
CN107522767A (en) * | 2017-10-13 | 2017-12-29 | 陈增光 | A kind of preparation method of turmeric saponin |
CN108567829A (en) * | 2018-06-04 | 2018-09-25 | 刘海军 | A kind of Chinese medicine and preparation method thereof for treating rheumatism osteoarthropathy |
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Application publication date: 20190730 |