CN110063815A - A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall - Google Patents
A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall Download PDFInfo
- Publication number
- CN110063815A CN110063815A CN201810048994.2A CN201810048994A CN110063815A CN 110063815 A CN110063815 A CN 110063815A CN 201810048994 A CN201810048994 A CN 201810048994A CN 110063815 A CN110063815 A CN 110063815A
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- China
- Prior art keywords
- syringe needle
- spiral
- blood vessel
- artificial blood
- preparation
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
- A61F2240/002—Designing or making customized prostheses
Abstract
The present invention relates to the ultrasonic nozzle preparation methods that a kind of application longitudinal wave prepares intravascular stent, belong to mechanical subject, biological manufacturing field.Using the method, preparation artificial blood vessel has become the big research hotspot of biological manufacturing field one.By reasonably applying ultrasonic spiral vibrating on direct write extrusion device, when so that hydrogel squeezing out, the artificial blood vessel's material contacted with vibration core is by along the Hybrid transducer vibration stress squeezed out on direction, the spiral flow of the minute yardstick of certain thickness is formed, and the surface topography for spiral fold of finally rerunning a movie out on crosslinking curing tubular fiber inner wall；It is allowed to be more nearly blood vessel physiological characteristic.
Description
Technical field
The present invention relates to the ultrasonic nozzle preparation methods that a kind of application longitudinal wave prepares intravascular stent, belong to mechanical subject, biology system
Make field.
Background technique
The people of conventional method (such as electrostatic spinning technique, the perfusion of reverse mould technology or traditional 3D printing technique are accumulated) preparation
Work blood vessel, drape characteristic of the inner wall surface without real blood vessels easily form thrombus after transplanting effect.With common preparation artificial blood vessel's
Method and apparatus is compared, and by ultrasonic spiral vibrating spray head, prepares small-caliber artificial blood vessel using coaxial direct writing means, and artificial
Blood vessel surface can form spiral fold, be closer to real blood vessels surface physiological structure, when blood stream intravascular forms spiral
Stream washes away blood vessel, to play the role of inhibition thrombosis.
Currently, with the rise of biological 3D printing, using sodium alginate, chitosan etc. can fast reaction crosslinking curing water
Carrier material of the gel as drug and cell, the direct forming doughnut in a manner of coaxial direct write, as artificial blood vessel or
It is deposited into the biological support of certain geometrical shape using it as basic unit, has in fields such as organizational project, pharmacy and clinical medicine
There is good application prospect.Using the method, preparation artificial blood vessel has become the big research hotspot of biological manufacturing field one.Pass through
Reasonably apply ultrasonic spiral vibrating on direct write extrusion device, when so that hydrogel squeezing out, is contacted with vibration core artificial
Vascular grafts are formed the spiral flow of the minute yardstick of certain thickness, and most by along the Hybrid transducer vibration stress squeezed out on direction
It reruns a movie out on crosslinking curing tubular fiber inner wall eventually the surface topography of spiral fold.
International patent documents (application number PCT/CN2014/078238) are related to a kind of medical bio institutional framework and its preparation
The production method and special equipment of method and special equipment are squeezed out hollow based on adherency crosslinking curing principle using Coaxial nozzle
Pipe, then biomaterial spraying is adhered to and forms functional layer on hollow tube, then successively accumulation forms complex adult, finally will
Synthesis Polymer Solution is sprayed on combined shaping external surface, ultimately forms three-dimensional structure, the device technique process is more complex.And
On the basis of this patent, Chinese patent literature (application number CN201410589938.1) is related to a kind of vascularization life structural body
One-stop preparation method is positioned at the Integrated manufacture of life structural body, realizes more rulers such as cell, structural material, growth factor
It is processed while spending object, to substantially reduce the complexity of traditional biological manufacture.Preparation system by syringe pump, two it is medical
Piston syringe, Coaxial nozzle composition, are led under the promotion of syringe pump by biomaterial stoste with crosslinking agent stoste respectively
Enter Coaxial nozzle, with the contact of two fluids, the doughnut of crosslinking curing is squeezed out by Coaxial nozzle, such design method has
The advantages that multiple target, multiple dimensioned, simple process.But above two patent cannot squeeze out in the crosslinking curing with spiral fold
Hollow fiber, different from above-mentioned two Patent equipment, the design core is using ultrasonic amplitude transformer and stainless steel syringe needle or is connected, and change
There is helicla flute distribution on width bar, by installing ultrasonic spiral vibrating spray head, there is one to indulge along extrusion direction when squeezing out hydrogel
Compound vibration is turned round when squeezing out hydrogel to squeeze out the doughnut of crosslinking curing of the inner wall with spiral fold along extrusion
There is the vibration an of Hybrid transducer in direction to squeeze out the doughnut of crosslinking curing of the inner wall with spiral fold.
Summary of the invention
This patent cannot form lacking for vascular inner surface spiral fold to solve the artificial blood vessel of existing equipment and method preparation
Point is made the hydrogel of crosslinking curing have one when squeezing out and is answered along the longitrorse squeezed out on direction using ultrasonic spiral vibrating spray head
Vibration is closed, the artificial blood vessel's material contacted can then rerun a movie out the surface topography of spiral fold under its effect, be allowed to more
Close to blood vessel physiological characteristic.
To achieve the goals above, this patent uses following scheme: a kind of to have spiral fold using ultrasonic nozzle preparation
The direct write preparation method of the artificial blood vessel of inner wall, including ultrasonic transducer (101), hollow screw groove type ultrasonic amplitude transformer
(102), fixed bracket (103), interior syringe needle or solid syringe needle (104), outer syringe needle (105), transducer enclosure (106), fixed spiral shell
Bolt (107), ring flange (108), special threeway (109), tower anti-suck rubber pad (110), heating rod (111) such as Fig. 1.It is special
Sign is: transducer enclosure (106), ultrasonic transducer (101), amplitude transformer and interior syringe needle or solid syringe needle (104), outer syringe needle
(105) be co-axially mounted, the concentricity of outer syringe needle (105) and interior syringe needle or thin solid needle bar (104) by respectively with special threeway
(109) cooperation on inside and outside cylindrical surface ensures, outer syringe needle (105) and special threeway (109) are using being interference fitted.Outside energy converter
Shell (106) lower end is connected to ring flange (108) by fixing bolt (107), and the upper end of special threeway (109) is also by fixed spiral shell
Bolt (107) is connected to ring flange (108), interior syringe needle or solid syringe needle (104) and screw groove type ultrasonic amplitude transformer (102) lower end
Spiral connection, there are equally distributed spiral grooves, heating rod (111) in hollow screw groove type ultrasonic amplitude transformer (102) surface
It is inner embedded in special threeway (109)；Required special threeway (109), material selection aluminium alloy, the concentricity with amplitude transformer are led to
It crosses upper circular face to contact with each other with ring flange (108) rounded face, guarantee is closely connected with multiple bolts, in special threeway
(109) heating rod (111) of small cylindrical is packed into wall thickness, for the heating in extrusion process；Required heating rod (111),
It selects heating rod to be adapted with special threeway (109) wall thickness greatly, so selecting small volume type, is easily installed；It is selected to add
Hot pin is connect by heat-resisting wire with electronic console, and must be used cooperatively with thermocouple in the course of work, until reaching institute
Need temperature.
A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall, feature exist
In: such as Fig. 2, prepare that doughnut operation is as follows, and by material stoste by threeway boss (201) inflow inner cavity, crosslinking agent passes through
Interior needle lumen (202) or solid syringe needle are contacted in bottom with material stoste, and crosslinking curing immediately, since there are Hybrid transducers
Vibration, have the crosslinking curing tubular fiber (203) of spiral wrinkled surface pattern on inner wall of finally rerunning a movie out.
A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall is specific to make
Standby operating procedure is as follows:
1. prepared by stoste: biomaterial and its crosslinking agent are configured to corresponding solvent by setting ratio to biomaterial original respectively
Liquid and crosslinking agent stoste, the sodium alginate that crosslinking agent selects 4% is respectively adopted in biomaterial stoste and crosslinking agent stoste in this patent
Colloidal sol and 3% calcium chloride solution；
2. equipment connects: supersonic generator being connect with ultrasonic transducer, syringe needle or solid syringe needle and amplitude transformer in stainless steel
Spiral connection, outer syringe needle are connect with special threeway, and last threeway is connect with ring flange, above to be all co-axially mounted；
3. the release of crosslinking agent and biomaterial stoste: 4% sodium alginate colloidal sol flows into from threeway boss, and along interior syringe needle
It flows down, 3% calcium chloride solution is flowed out from interior syringe needle, and exit and biomaterial stoste are crosslinked, this process provides extruding by syringe pump
Power, while mechanical wave is passed to by screw groove type ultrasonic amplitude transformer by the conversion of ultrasonic transducer, to give stainless steel
The vibration of first Hybrid transducer of interior syringe needle or solid needle；
4. prepared by doughnut: 4% sodium alginate colloidal sol and the crosslinking of 3% calcium chloride solution form coaxial flow in outer syringe needle,
It is formed by crosslinking agent stoste crosslinking curing of the annular biomaterial stoste by core, out from i.e. formation has spiral after outer syringe needle
The doughnut of the tubulose of fold；
5. syringe pump is closed in off-test, the connection with ultrasonic generator is disconnected.
The present invention has substantive distinguishing features following prominent and significant technological progress compared with prior art
1. in this patent, hollow spiral amplitude transformer cooperates special threeway both and can meet the extrusion of homogenous material or meets two
Plant the crosslinked extrused of material；
2. the artificial blood vessel of existing preparation is mostly without perficial helical fold morphology, this patent utilizes screw groove type ultrasonic vibrator,
Longitudinal component and torsional component are increased, and the artificial blood vessel with spiral fold of preparation is closer to the blood vessel under physiological environment
Structure；
3. being embedded in heating bar in special threeway in this patent, can heat in homogenous material extrusion process to it makes its holding
Molten condition；
4. transducer enclosure shields in this patent, multiple holes are outputed again in structure, play heat dissipation while it is working
Effect；
5. tower anti-suck rubber pad can stop experimental material to pour in threeway upper semisection, prevent from having an impact amplitude transformer.
Detailed description of the invention
Fig. 1 is structural schematic diagram；
Fig. 2 is the doughnut schematic diagram of expression surface spiral
Fig. 3 is structure top view
In Fig. 1, single-excitation ultrasonic oval vibration energy converter (101), screw groove type ultrasonic amplitude transformer (102), fixed bracket (103), interior syringe needle
Or thin solid needle bar (104), outer syringe needle (105), transducer enclosure (106), fixing bolt (107), ring flange (108) are special
Threeway (109), anti-suck sponge (110), heating rod (111)；
, there is the crosslinking curing tubular fiber of spiral wrinkled surface pattern in threeway boss (201) in Fig. 2, interior needle lumen (202)
(203).
Specific embodiment
Embodiment one: preparation has sodium alginate-calcium chloride doughnut of spiral grain
1. interior syringe needle or solid syringe needle (104) are tightened in screw groove type ultrasonic amplitude transformer (102) lower end around thread helix；
2. the transducer enclosure (106) of ultrasonic transducer (101) will be protected to be connected to ring flange by fixing bolt (107)
(108)；
3. special threeway (109) upper end is fixed on ring flange (108), at the same by the bracket of fixed device also be secured to ring flange it
On；
4. the syringe for filling calcium chloride solution is connected at energy converter upper hollow, the syringe phase of sodium alginate is filled
Answer leather hose to be connected on threeway boss (201), by fixed bracket (103) by device integral installation on 3D biometric print machine；
5. ultrasonic transducer (101) the two poles of the earth connect ultrasonic generator, while squeezing out to squeeze out and obtaining the alginic acid with spiral grain
Sodium-calcium chloride doughnut.
Embodiment two: the PLA material that surface has spiral grain is directly extruded
1. interior syringe needle or thin solid needle bar (104) are tightened in screw groove type ultrasonic amplitude transformer (102) lower end around thread helix；
2. the transducer enclosure (106) of ultrasonic transducer (101) will be protected to be connected to ring flange by fixing bolt (107)
(108)；
3. special threeway (109) upper end is fixed on ring flange (108), while fixed bracket (103) also are secured to ring flange
(108) on；
4. the PLA of melting is connected on threeway boss (201) by pipe tool, integral installation is on 3D biometric print machine；
5. heating rod (111) is heated first, reaches PLA to temperature and melt repaired temperature；
6. ultrasonic transducer (101) the two poles of the earth connect ultrasonic generator, expression surface has the PLA material of spiral grain, makes it certainly
It is so cooling.
Claims (5)
1. a kind of direct write preparation method of the artificial blood vessel with spiral fold inwall and ultrasonic Coaxial nozzle, including ultrasonic transduction
Device (101), hollow screw groove type ultrasonic amplitude transformer (102), fixed bracket (103), interior syringe needle or solid syringe needle (104),
Outer syringe needle (105), transducer enclosure (106), fixing bolt (107), ring flange (108), special threeway (109), tower is anti-down
It inhales rubber pad (110), heating rod (111) such as Fig. 1 is it is characterized by: transducer enclosure (106), ultrasonic transducer (101), luffing
Bar and interior syringe needle or solid syringe needle (104), outer syringe needle (105) are co-axially mounted, outer syringe needle (105) and interior syringe needle or thin solid needle bar
(104) concentricity with the cooperation on the inside and outside cylindrical surface of special threeway (109) by respectively ensureing, outer syringe needle (105) and special
Threeway (109) processed is using interference fit；Transducer enclosure (106) lower end is connected to ring flange by fixing bolt (107)
(108), the upper end of special threeway (109) is connected to ring flange (108), interior syringe needle or solid needle also by fixing bolt (107)
Head (104) is connect with screw groove type ultrasonic amplitude transformer (102) lower end spiral, hollow screw groove type ultrasonic amplitude transformer
(102) there are equally distributed spiral grooves on surface, and heating rod (111) is inner embedded in special threeway (109).
2. the direct write preparation method of artificial blood vessel with spiral fold inwall according to claim 1 a kind of and ultrasound
Coaxial nozzle, steps are as follows for specific preparation manipulation:
Syringe equipped with crosslinking agent passes through transducer enclosure and is connected with hollow portion at the top of energy converter；Note equipped with material stoste
Emitter is connect with threeway boss, and syringe connects syringe pump；
Ultrasonic transducer is connected, mechanical wave is passed into screw groove type ultrasonic amplitude transformer, to give interior syringe needle or solid needle
The vibration of first Hybrid transducer；
Extruded material, should be noted at this time must crosslinked fluid first squeeze out, conducive to hollow structure is formed；
It by fixed bracket, is integrally assemblied on 3D biometric print machine, there is the hollow of spiral fold by outer syringe needle expression surface
Fiber；
Syringe pump is closed in off-test.
3. the direct write preparation method of artificial blood vessel with spiral fold inwall according to claim 1 a kind of and ultrasound
Coaxial nozzle, required special threeway (109) are characterized in that material selection aluminium alloy, the concentricity with amplitude transformer passes through
Upper circular face contacts with each other with ring flange (108) rounded face, closely connects guarantee with multiple bolts, in special threeway (109)
The heating rod (111) of small cylindrical is packed into wall thickness, for the heating in extrusion process.
4. the direct write preparation method of artificial blood vessel with spiral fold inwall according to claim 1 a kind of and ultrasound
Coaxial nozzle, required heating rod (111) are characterized in that, heating rod is selected to be adapted with special threeway (109) wall thickness greatly, so
Small volume type is selected, is easily installed；Selected heating rod is connect by heat-resisting wire with electronic console, and in the course of work
It must be used cooperatively with thermocouple, until reaching required temperature.
5. the direct write preparation method of artificial blood vessel with spiral fold inwall according to claim 1 a kind of and ultrasound
Coaxial nozzle, prepares that doughnut operation is as follows, and by material stoste by threeway boss (201) inflow inner cavity, crosslinking agent passes through
Interior needle lumen (202) or solid syringe needle are contacted in bottom with material stoste, and crosslinking curing immediately, since there are Hybrid transducers
Vibration, have the crosslinking curing tubular fiber (203) of spiral wrinkled surface pattern on inner wall of finally rerunning a movie out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810048994.2A CN110063815A (en) | 2018-01-18 | 2018-01-18 | A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810048994.2A CN110063815A (en) | 2018-01-18 | 2018-01-18 | A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall |
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| Publication Number | Publication Date |
|---|---|
| CN110063815A true CN110063815A (en) | 2019-07-30 |
Family
ID=67364714
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|---|---|---|---|
| CN201810048994.2A Pending CN110063815A (en) | 2018-01-18 | 2018-01-18 | A kind of direct write preparation method of the artificial blood vessel using ultrasonic nozzle preparation with spiral fold inwall |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113546218A (en) * | 2021-07-21 | 2021-10-26 | 南昌大学第二附属医院 | Method and formula for in-situ construction of PRP gel tissue engineering compound for different tissue regeneration |
| CN115232782A (en) * | 2022-07-16 | 2022-10-25 | 南昌大学 | Coaxial microfluid-based double-exposure micro-wrinkle blood vessel processing platform and method |
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Application publication date: 20190730 |