CN110057722A - The experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase - Google Patents
The experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase Download PDFInfo
- Publication number
- CN110057722A CN110057722A CN201910215454.3A CN201910215454A CN110057722A CN 110057722 A CN110057722 A CN 110057722A CN 201910215454 A CN201910215454 A CN 201910215454A CN 110057722 A CN110057722 A CN 110057722A
- Authority
- CN
- China
- Prior art keywords
- microballoon
- fluid
- dispersity
- mobile phase
- experimental provision
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002474 experimental method Methods 0.000 title claims abstract description 16
- 239000012530 fluid Substances 0.000 claims abstract description 143
- 230000004931 aggregating effect Effects 0.000 claims abstract description 28
- 239000000463 material Substances 0.000 claims description 28
- 239000000084 colloidal system Substances 0.000 claims description 25
- 230000010355 oscillation Effects 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 13
- 230000002572 peristaltic effect Effects 0.000 claims description 10
- 238000009826 distribution Methods 0.000 claims description 8
- 241000894007 species Species 0.000 claims description 6
- 241001474374 Blennius Species 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 241001465754 Metazoa Species 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 230000002596 correlated effect Effects 0.000 claims description 4
- 229910003460 diamond Inorganic materials 0.000 claims description 4
- 239000010432 diamond Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 2
- 229920001222 biopolymer Polymers 0.000 claims description 2
- 230000005672 electromagnetic field Effects 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 1
- 239000000416 hydrocolloid Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 239000000499 gel Substances 0.000 description 16
- 230000005855 radiation Effects 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 230000007717 exclusion Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000004005 microsphere Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- 229910021642 ultra pure water Inorganic materials 0.000 description 2
- 239000012498 ultrapure water Substances 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- RECVMTHOQWMYFX-UHFFFAOYSA-N oxygen(1+) dihydride Chemical compound [OH2+] RECVMTHOQWMYFX-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- -1 structure is simple Substances 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention provides the experimental provisions and experimental method of microballoon dispersity in a kind of adjustment mobile phase, comprising: fluid delivery system, flow rate detector, in fluid EZ characteristic observation model and processor；Wherein, the output end of the fluid delivery system is connected with the fluid channel in the observation model of EZ characteristic in the fluid, for conveying the fluid containing microballoon thereto；The processor is connected with the flow rate detector, the fluid flow rate data sent to receive the flow rate detector, and the fluid flow rate data is adjusted according to the aggregating state of the EZ peak width data of record and the microballoon, so that the microballoon in the fluid channel can be uniformly distributed.
Description
Technical field
The present invention relates to fluid emulation technical fields, in particular to microballoon dispersity in a kind of adjustment mobile phase
Experimental provision and experimental method.
Background technique
According to hydrophilic viewpoint, it is exactly hydrophilic less than 90 degree, is exactly the molecule that hydrophobic has polar group greater than 90 degree, to water
There is big affine ability, hydrone can be attracted, or be dissolved in water.The appearance for the solid material that this kind of molecule is constituted, Yi Beishui
Institute is moist, and the material that this molecule is made into is exactly water wetted material.4th phase (EZ) of water: active water is formed in hydrophilic interface, EZ
Formation precisely due to hydrophilic interface is there are surface charge, these can be used as bonding layer template, and monolayer can also form EZ.It lacks
The material of few surface charge not will form EZ.EZ is the water molecule layer staggered superposition structure of hexagon, and ZE broadens i.e. number of plies increase,
Reducing is also that layering is reduced, and EZ is reduced with the increase gradual change of fluid velocity to completely disappearing.The density of EZ is greater than water, and molecule more has
Sequence, structure is similar to ice, for more alkaline exclusion band Exclusion Zone water (EZ water), can by water ion, small point
The substances such as son all exclude, H3O2Negatively charged, all more sensitive to acousto-optic 9 Cr 2 steel using electromagnetic heating, refractive index is higher than liquid water, to about 3um
Wavelength it is infrared most sensitive, will increase the accumulation of EZ water molecule layer, widen the EZ width in hydrophilic interface, EZ is liquid water
To the intermediate state of solid ice, energy can be stored, moreover it is possible to influence the distribution of particle.Especially in the stream containing micrograined texture
In body, the change width of EZ influences whether the dispersity of particle, however in the prior art on still without relevant device to containing
Microballoon dispersity in the fluid of EZ is studied.
Summary of the invention
In consideration of it, the invention proposes the experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase,
Aim to solve the problem that problem above existing in the prior art.
First aspect present invention proposes a kind of experimental provision for adjusting microballoon dispersity in mobile phase, comprising: fluid
Conveying device, flow rate detector, in fluid EZ characteristic observation model and processor；Wherein, the fluid delivery system is defeated
Outlet is connected with the fluid channel in the observation model of EZ characteristic in the fluid, for conveying the stream containing microballoon thereto
Body；The processor is connected with the flow rate detector, the fluid flow rate data sent to receive the flow rate detector,
And according to the microballoon of record be in the EZ peak width data point reuse of aggregating state described in fluid flow rate data so that described
Microballoon in fluid channel becomes equally distributed state from initial aggregating state.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, the fluid delivery system is
Peristaltic pump or stilligout.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, in the fluid delivery system
The flow velocity V of fluid and the relational expression of the EZ peak width d are as follows:
D=f (V)={ C3, V < 30ul/min；1/a2V+b2,30ul/min < V < 320ul/min；0, V > 320ul/
min}
Wherein, C3, a2, b2 are constant.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, the dispersity of the microballoon
It is positively correlated with the change in flow of the fluid, the change width with the region EZ is in inverse correlation.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, further includes: infrared ray transmitting
EZ regional alignment setting in device, with the fluid in the observation model of EZ characteristic, also, the RF transmitter is defeated
Outlet is connected with the processor, to send infrared intensity data to the processor.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, further includes: to the stream
The observation model of EZ characteristic applies the electromagnetic vibrator of predeterminated frequency in body；Wherein, the electromagnetic vibrator and the processor
It is connected, to send electric and magnetic oscillation frequency data to the controller.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, EZ characteristic in the fluid
Observation model includes: the gel piece made of hydrophilic colloidal materials and solvent；Wherein, it is distributed in the gel piece several logical
Road；The region EZ is distributed in the boundary of hydrophilic colloidal materials and solvent in the gel piece.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, the fluid channel is in cylinder
Shape, ellipse, rectangular, taper, diamond shape or dendriform.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, the hydrophilic colloidal materials are
Biopolymerization species colloid, plant seed powder class colloid, plant extraction species colloid, fiber and cellulose derivative class colloid form sediment
Powder class colloid, animal class hydrophilic colloid, pectin or seaweeds colloid.
Further, in above-mentioned adjustment mobile phase in the experimental provision of microballoon dispersity, the solvent is ultrapure water, goes
Ionized water or soluble salt solutions.
The experimental provision of microballoon dispersity in adjustment mobile phase provided by the invention, by adjusting fluid channel aperture,
Relationship between fluid flow rate and infrared intensity so that microballoon in fluid channel can with the change width in the region EZ and by
Dispersity becomes equally distributed state, and the device is versatile, can industrially be applied on a large scale.
Second aspect of the present invention provides a kind of experimental method for adjusting the experimental provision of microballoon dispersity in mobile phase,
The following steps are included: conveying contains microballoon in the fluid channel containing aggregating state microballoon in EZ characteristic observation model into fluid
Fluid；In both the aperture of fluid channel and fluid flow rate under conditions of any parameter constant, adjusted with default lifting sequence
Another whole parameter, to change the width in the region EZ, until the microballoon in the fluid channel becomes uniform from aggregating state
The state of distribution.
Further, in above-mentioned adjustment mobile phase in the experimental method of the experimental provision of microballoon dispersity, further includes:
In the aperture of fluid channel, fluid flow rate and infra-red intensity three under conditions of any parameter constant, with default lifting sequence
Other two parameter is adjusted, to change the width in the region EZ, until the microballoon in the fluid channel becomes equal from aggregating state
The state of even distribution.
Further, in above-mentioned adjustment mobile phase in the experimental method of the experimental provision of microballoon dispersity, further includes:
The item of parameter constant any one or more in the aperture of fluid channel, fluid flow rate, infra-red intensity and electric and magnetic oscillation frequency
Under part, other parameter is adjusted with default lifting sequence, to change the width in the region EZ, until the microballoon in the fluid channel
Equally distributed state is become from aggregating state.
The experimental method of the experimental provision of microballoon dispersity in adjustment mobile phase provided by the invention, it is contemplated that fluid is logical
The aperture in road, fluid flow rate, the multifactor influence to EZ peak width of infra-red intensity, exist to microballoon to probe into out EZ width
The influence of dispersity in fluid provides data supporting and theoretical direction for the application of EZ.
Detailed description of the invention
Fig. 1 is the structural block diagram that the experimental provision of microballoon dispersity in mobile phase is adjusted in the embodiment of the present invention；
Fig. 2 is the observation schematic diagram in the region EZ in the embodiment of the present invention；
Fig. 3 is the another structural block diagram that the experimental provision of microballoon dispersity in mobile phase is adjusted in the embodiment of the present invention；
Fig. 4 is in the embodiment of the present invention for observing the manufacturing process schematic diagram of the model of EZ characteristic in fluid；
Fig. 5 is in the embodiment of the present invention for observing the another manufacturing process schematic diagram of the model of EZ characteristic in fluid.
Specific embodiment
The following is a preferred embodiment of the present invention, it is noted that for those skilled in the art
For, without departing from the principle of the present invention, some improvements and modifications can also be made, these improvement and modification are also considered as
Protection scope of the present invention.
Experimental provision embodiment:
Refering to fig. 1, the embodiment of the invention provides a kind of experimental provision of microballoon dispersity in adjustment mobile phase, packets
Include: fluid delivery system, flow rate detector, in fluid EZ characteristic observation model 11 and processor；Wherein, the fluid conveying
The output end of device is connected with the fluid channel 113 in the observation model 11 of EZ characteristic in the fluid, for defeated thereto
Send the fluid containing microballoon；The processor is connected with the flow rate detector, sends to receive the flow rate detector
Fluid flow rate data, and the fluid flow rate is adjusted according to the EZ peak width data of record and the dispersity of the microballoon
Data, so that the microballoon in the fluid channel can be uniformly distributed.
As shown in Fig. 2, occurring the area of light and shade variation between the gel and solvent of the observation model 11 of EZ characteristic in a fluid
Domain is the region EZ, and d is the width for representing the region EZ in figure, the width d in the region EZ can be obtained by microscopic, and record
Enter processor.The dispersity of microballoon can also be obtained by microscopic, and typing processor.It is flowed in fluid delivery system
The flow velocity V of body and the relational expression of the EZ peak width d are as follows:
D=f (V)={ C3, V < 30ul/min；1/a2V+b2,30ul/min < V < 320ul/min；0, V > 320ul/
min}
Wherein, C3, a, b2 are constant.
Fluid delivery system can be peristaltic pump or stilligout.For example, when fluid delivery system is peristaltic pump, peristaltic pump
Speed (RPM) and the relationship of fluid flow rate (ul/min) can be obtained by following data:
50RPM=3500ul/min
25RPM=1500ul/min
15RPM=800ul/min
5RPM=210ul/min
1RPM=30ul/min
0.5RPM=12.5ul/min
6.5RPM=320ul/min
1.5RPM=40ul/min
1.2RPM=30ul/min
The relationship of fluid flow rate and EZ peak width can be obtained by following data:
Flow velocity V=30ul/min width d=146um
Flow velocity V=40ul/min width d=124um
Flow velocity V=60ul/min width d=59um
Flow velocity V=320ul/min width d=0um
Therefore, the relational expression of above-mentioned flow velocity V Yu the EZ peak width d can be obtained by above each data fitting.
In addition, the width d relationship in the region aperture Φ and EZ of fluid channel can be obtained by following data:
Φ=0.2mmEZ, d=140um
Φ=0.5mm EZ, d=130um
Φ=2.7mm EZ, d=130um
D=f (Φ)={ C1, Φ > dmax；1/a1Φ+b1dmin<Φ<dmax；C2, Φ < dmin}
C1, C2, a1, b1 are constant, when aperture Φ is greater than the maximum value of EZ width or less than the minimum of EZ width
When value, EZ width is definite value, when between, EZ width and aperture Function Fitting in inverse ratio.It therefore deduces that,
When the aperture of fluid channel determines, the width data in the region EZ is also determined that.
By above it is known that the flow velocity of fluid can be 30-320 μ l/min, the EZ in the fluid delivery system
The width in region can be 0-146 μm, and when the width in the region EZ approaches 140 μm, the aperture of fluid channel can be 0.2-
2.7mm。
Further, the revolving speed that peristaltic pump is adjusted by processor works as the revolving speed of peristaltic pump by the discovery of micro- sem observation
When for 1.2RPM, in the boundary of gel and solvent, there are the regions EZ, when the revolving speed of peristaltic pump is more than 1.8RPM, the region EZ
Layering starts to reduce, and when continuing growing the revolving speed of peristaltic pump to 3.2RPM, the layering in the region EZ reduces more obvious, but fluid is logical
Microballoon in road cannot be still uniformly distributed, and there are at the interfacial water of EZ, microballoon concentration or smaller, the revolving speed of peristaltic pump reaches
When 6.2RPM, the region EZ almost disappears, and the distribution of microballoon in the fluid passage is substantially uniform.The dispersity of available microballoon
It is positively correlated with the change in flow of the fluid, the change width with the region EZ is in inverse correlation.Further, since infrared radiation
The width in the region EZ can be changed, it therefore, can be by adjusting the pass between the aperture of fluid channel, fluid flow rate and infrared intensity
System, to adjust the distribution of microballoon in fluid.
It can also include: the observation of EZ characteristic in RF transmitter, with the fluid in the present embodiment refering to Fig. 3
The region EZ 112 in model 11 is directed at setting, also, the output end of the RF transmitter is connected with the processor,
To send infrared intensity data to the processor.Processor can be in the EZ of aggregating state according to the microballoon of record
Infrared intensity data described in peak width data point reuse to change the width in the region EZ so that microballoon in fluid channel by
Initial aggregating state becomes equally distributed state.
It, can also be by setting electromagnetic vibrator (not shown) with the observation to EZ characteristic in fluid in the present embodiment
The electromagnetic field of model application predeterminated frequency；Wherein, the electromagnetic vibrator is connected with the processor, to the control
Device sends electric and magnetic oscillation frequency data.In use, the observation model of EZ characteristic in fluid can be placed in electromagnetic vibrator, root
The frequency of electromagnetic vibrator is adjusted according to requirement of experiment.Such as when applying 3kHZ to observation model, EZ zones vanishes or width
Become smaller.,
It can be concluded that, the experimental provision of microballoon dispersity, passes through tune in adjustment mobile phase provided by the invention by above
Relationship between rectification body channel aperture, fluid flow rate and infrared intensity, so that the microballoon in fluid channel can be with the area EZ
The change width in domain and equally distributed state is become from aggregating state, the device is versatile, can industrially obtain big
The application of range.
In above-described embodiment, the observation model of EZ characteristic includes: to be made of hydrophilic colloidal materials and solvent in the fluid
Gel piece；Wherein, if dry passage is distributed in the gel piece, the solution containing microballoon is perfused in each channel；Institute
It states the boundary of hydrophilic colloidal materials and solvent in gel piece and the region EZ is distributed with.
Specifically, channel can be one or more.When channel is multiple, each channel can be parallel to each other,
It can be with interlaced arrangement.The shape in channel can determines according to actual conditions, such as can it is cylindrical, oval, rectangular, cone
Shape, diamond shape or dendriform.Hydrophilic colloidal materials are biopolymer class colloid, plant seed powder class colloid, plant extraction species glue
Body, fiber and cellulose derivative class colloid, starch colloid, animal class hydrophilic colloid, pectin and/or seaweeds colloid.Its
In, the seaweeds colloid can be agar, carragheen, alginic acid or seaweed salt；The cellulose derivative class colloid can be with
For sodium carboxymethylcellulose；The biopolymerization species colloid can be xanthan gum or gellan gum；The plant seed powder class colloid
It can be locust bean gum or guar gum；The animal class hydrophilic colloid can be gelatin.Solvent can be ultrapure water, deionization
Water or soluble salt solutions, such as physiological saline (NaCl solution that mass concentration is 0.9%).
In the present embodiment, the concentration of hydrophilic colloidal materials can be 0.01-0.25g/ml in the gel of formation.Preferably
0.5g/30ml, 2.5g/110ml or 0.5g/50ml.
Referring again to such as Fig. 2, by that can find that the width in the region between gel and solvent broadens after infrared radiation, and
Remoter apart from the region, the absorbance of infrared absorption is smaller；Microballoon is in the solution except the region, fall off rate substantially one
It causes, speed gradually slows down after touching the region, illustrates that the substance in the region has higher viscosity relative to water；In core
In magnetic resonance experiments, substance is shorter relative to the relaxation time of water in the region, these all meet EZ (Exclusion Zone)
Characteristic, occur EZ between gel and solvent to demonstrate.
In conjunction with Fig. 4 and Fig. 5, in the embodiment of the present invention in fluid the observation model of EZ characteristic it is specific the production method is as follows:
Step S1, choose hydrophilic colloidal materials and solvent mixing after, heating stirring, mixture boiling after close fire, continue stirring until
Interface is smooth, obtains 1 ' of gel piece after cooling；Wherein, before the hydrophilic colloidal materials cooled and solidified, Xiang Suoshu mixture
It is middle that several inserts are added；Step S2 extracts the insert out after the colloidal materials cooled and solidified, and tool can be obtained
There is the model for being used to observe EZ characteristic in fluid of several hollow channels；Injection is containing micro- in step S3, Xiang Suoshu hollow channel
The fluid of ball, in order to observe the characteristic of EZ.
Specifically, the material for 2 ' of insert being added in the mixture can be resin material, wood materials, ceramic material
Material or metal material.Such as resin material can be polystyrene, glass material can be acrylic.The size of 2 ' of insert,
Shape can be adjusted according to actual design requirement, it is preferred that 2 ' of insert can cylindrical, oval, rectangular, taper,
Diamond shape or dendriform, to prepare different types of hollow channel.The maximum width in the insert section is 0.2-60mm.Example
Can such as select basal diameter be 3mm cylindrical structure, length be respectively 2mm, 2mm, 7mm square cylinder and length and width,
Height is respectively the square cylinder of 3mm, 3mm, 8mm.A channel can be only formed in gel piece, can also be formed multiple logical
Road.Meanwhile the width of EZ in hydrophilic interface can be changed by changing the size in channel.The material of microballoon be resin material,
Magnetic material or fluorescent material.Such as resin material can be polystyrene material.The partial size of the microballoon is 1-20 μm, preferably
It is 1-10 μm, such as 1.2 μm, 5 μm, 10 μm.
As can be seen that the observation model of EZ characteristic in fluid, structure is simple, gel block structure pair in the embodiment of the present invention
Temperature and water content requirement are lower, therefore to the of less demanding of use environment, increase the ease of use of observation model；Production
The water wetted material selected in the process is from a wealth of sources, low in cost；In process, shape, the size of hydrophilic gel block are easy to control
System is conducive to the versatility for improving model；In addition, obtained gel piece is easy to save, be conducive to the recycling for improving model
Rate.
EXPERIMENTAL Example:
In adjustment mobile phase in the present invention microballoon dispersity experimental method the following steps are included:
Convey the stream containing microballoon in EZ characteristic observation model in the fluid channel containing aggregating state microballoon into fluid
Body；
In the aperture of fluid channel, fluid flow rate the two under conditions of any parameter constant, adjusted with default lifting sequence
Other two whole parameter, to change the width in the region EZ, until the microballoon in the fluid channel becomes uniform from aggregating state
The state of distribution.
Since infrared radiation can change the width in the region EZ, can also include: in the another embodiment of the present embodiment
It is suitable with default lifting in the aperture of fluid channel, fluid flow rate and infra-red intensity three under conditions of any parameter constant
Sequence adjusts other two parameter, to change the width in the region EZ, until the microballoon in the fluid channel is become from aggregating state
Equally distributed state.
Since electric and magnetic oscillation also will affect the change width in the region EZ, another embodiment of the present embodiment can also be wrapped
It includes: the parameter constant any one or more in the aperture of fluid channel, fluid flow rate, infra-red intensity and electric and magnetic oscillation frequency
Under conditions of, other parameter is adjusted with default lifting sequence, to change the width in the region EZ, until in the fluid channel
Microballoon becomes equally distributed state from aggregating state.
Specifically, the micro-sphere structure of a certain amount of aggregating state is perfused in the fluid passage before experiment starts；It is then turned on
Each component in experimental provision adjusts the frequency of fluid flow rate, infra-red intensity, fluid channel aperture or electric and magnetic oscillation from small to large
Rate, until the micro-sphere structure in fluid channel is dispersed in the solution of channel.
It should be noted that default lifting sequence refers to the numerical value of each parameter according to by small in three of the above embodiment
To big sequence adjustment or descending sequence adjustment.The specific variation needed according to each parameter and microballoon dispersity
Relationship determines, such as the dispersity of microballoon and the change in flow of fluid are positively correlated, then when adjusting flow velocity can be from as low as
Greatly；The dispersity of microballoon and the change width in the region EZ are in inverse correlation, then can be from greatly to the width in the small adjustment region EZ.Into
One step, since the aperture and electric and magnetic oscillation frequency of EZ peak width and fluid channel are in inverse ratio, with infrared radiation intensity in just
Than.So can corresponding selective body channel aperture, electric and magnetic oscillation frequency and infra-red intensity numerical value adjustment sequence.
When it is implemented, each parameter can be adjusted in the following way:
(1) under conditions of the aperture of the fluid channel is constant, fluid flow rate and infrared intensity are adjusted, to change the area EZ
The width in domain, until the microballoon becomes equally distributed state from aggregating state.
(2) under conditions of the fluid flow rate is constant, the aperture of infrared intensity and fluid channel is adjusted, to change the area EZ
The width in domain, until the microballoon becomes equally distributed state from aggregating state.
(3) under conditions of the infrared intensity is constant, the aperture of fluid flow rate and fluid channel is adjusted, to change the area EZ
The width in domain, until the microballoon becomes equally distributed state from aggregating state.
(4) under conditions of the infrared intensity and electric and magnetic oscillation frequency-invariant, fluid flow rate and fluid channel are adjusted
Aperture, to change the width in the region EZ, until the microballoon becomes equally distributed state from aggregating state.
(5) under conditions of the electric and magnetic oscillation frequency-invariant, fluid flow rate, infra-red intensity and fluid channel are adjusted
Aperture, to change the width in the region EZ, until the microballoon becomes equally distributed state from aggregating state.
Certainly, the above exemplary only explanation of several regulative modes, in actual experiment, the regulative mode of each parameter not office
It is limited to the above several ways, suitable regulative mode can be selected with experimental concrete condition.
To sum up, in the present embodiment, since fluid flow rate, infrared radiation, the aperture of fluid channel and electric and magnetic oscillation are equal
It will affect the width distribution in the region EZ, therefore, adjustment can be selected according to different applications and the property of different fluid
One or more parameters in fluid flow rate, infrared radiation, the aperture of fluid channel or electric and magnetic oscillation frequency, so that fluid
In can be dispersed in the solution of channel in the microballoon of aggregating state, may finally determine can be such that microballoon becomes from aggregating state
For the optimum valuing range of each parameter of uniform distribution.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (12)
1. the experimental provision of microballoon dispersity in a kind of adjustment mobile phase characterized by comprising fluid delivery system, stream
The observation model and processor of EZ characteristic in fast detector, fluid；Wherein,
The output end of the fluid delivery system is connected with the fluid channel in the observation model of EZ characteristic in the fluid, uses
In conveying the fluid containing microballoon thereto；
The processor is connected with the flow rate detector, the fluid flow rate number sent to receive the flow rate detector
According to, and according to the microballoon of record be in the EZ peak width data point reuse of aggregating state described in fluid flow rate data so that
Microballoon in the fluid channel becomes equally distributed state from initial aggregating state.
2. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 1, which is characterized in that the stream
Body conveying device is peristaltic pump or stilligout.
3. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 1, which is characterized in that the stream
The flow velocity V of fluid and the relational expression of the EZ peak width d are as follows in body conveying device:
Wherein, C3, a2, b2 are constant.
4. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 1, which is characterized in that described micro-
The dispersity of ball and the change in flow of the fluid are positively correlated, and the change width with the region EZ is in inverse correlation.
5. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 1, which is characterized in that also wrap
It includes: the EZ regional alignment setting in RF transmitter, with the fluid in the observation model of EZ characteristic, also, it is described red
The output end of outside line transmitter is connected with the processor, to send infrared intensity data to the processor.
6. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 5, which is characterized in that also wrap
It includes: applying the electromagnetic vibrator of predeterminated frequency electromagnetic field to the observation model to EZ characteristic in the fluid；Wherein, the electricity
Magnetic vibrator is connected with the processor, to send electric and magnetic oscillation frequency data to the controller.
7. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 1, which is characterized in that the stream
The observation model of EZ characteristic includes: the gel piece made of hydrophilic colloidal materials and solvent in body；Wherein,
Several fluid channels are distributed in the gel piece；The boundary of hydrophilic colloidal materials and solvent is distributed in the gel piece
There is the region EZ.
8. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 7, which is characterized in that the stream
Body channel is cylindrical, oval, rectangular, taper, diamond shape or dendriform.
9. the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 7, which is characterized in that the parent
Hydrocolloid material is that biopolymer class colloid, plant seed powder class colloid, plant extraction species colloid, fiber and cellulose are derivative
Species colloid, starch colloid, animal class hydrophilic colloid, pectin or seaweeds colloid.
10. the reality of the experimental provision of microballoon dispersity in a kind of mobile phase of adjustment as claimed in any one of claims 1-9 wherein
Proved recipe method, which comprises the following steps:
Convey the fluid containing microballoon in EZ characteristic observation model in the fluid channel containing aggregating state microballoon into fluid；
In both the aperture of fluid channel and fluid flow rate under conditions of any parameter constant, adjusted with default lifting sequence another
Outer two parameters, to change the width in the region EZ, until the microballoon in the fluid channel becomes uniform from aggregating state
The state of distribution.
11. the experimental method of the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 10,
It is characterized in that, further includes: the condition of any parameter constant in the aperture of fluid channel, fluid flow rate and infra-red intensity three
Under, other two parameter is adjusted with default lifting sequence, to change the width in the region EZ, until the microballoon in the fluid channel
Equally distributed state is become from aggregating state.
12. the experimental method of the experimental provision of microballoon dispersity in adjustment mobile phase according to claim 10,
It is characterized in that, further includes: any in the aperture of fluid channel, fluid flow rate, infra-red intensity and electric and magnetic oscillation frequency
Or under conditions of multiple parameters are constant, other parameter is adjusted with default lifting sequence, to change the width in the region EZ, until institute
The microballoon stated in fluid channel becomes equally distributed state from aggregating state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910215454.3A CN110057722A (en) | 2019-03-21 | 2019-03-21 | The experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910215454.3A CN110057722A (en) | 2019-03-21 | 2019-03-21 | The experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110057722A true CN110057722A (en) | 2019-07-26 |
Family
ID=67317153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910215454.3A Pending CN110057722A (en) | 2019-03-21 | 2019-03-21 | The experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110057722A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070163967A1 (en) * | 2006-01-17 | 2007-07-19 | Pollack Gerald H | Separating Components Of Aqueous Mixtures, Suspensions, and Solutions |
| US20090134090A1 (en) * | 2006-01-17 | 2009-05-28 | Gerald H. Pollack | Separating components of aqueous mixtures, suspensions, and solutions |
| US20110097218A1 (en) * | 2009-10-21 | 2011-04-28 | Pollack Gerald H | Method and apparatus for generating a fluid flow |
| WO2012094170A2 (en) * | 2011-01-03 | 2012-07-12 | The Regents Of The University Of California | Methods and microfluidic devices for concentrating and transporting particles |
| WO2018187305A1 (en) * | 2017-04-03 | 2018-10-11 | 4th-Phase, Inc. | Ez separation |
-
2019
- 2019-03-21 CN CN201910215454.3A patent/CN110057722A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070163967A1 (en) * | 2006-01-17 | 2007-07-19 | Pollack Gerald H | Separating Components Of Aqueous Mixtures, Suspensions, and Solutions |
| US20090134090A1 (en) * | 2006-01-17 | 2009-05-28 | Gerald H. Pollack | Separating components of aqueous mixtures, suspensions, and solutions |
| US20110097218A1 (en) * | 2009-10-21 | 2011-04-28 | Pollack Gerald H | Method and apparatus for generating a fluid flow |
| WO2012094170A2 (en) * | 2011-01-03 | 2012-07-12 | The Regents Of The University Of California | Methods and microfluidic devices for concentrating and transporting particles |
| WO2018187305A1 (en) * | 2017-04-03 | 2018-10-11 | 4th-Phase, Inc. | Ez separation |
Non-Patent Citations (4)
| Title |
|---|
| MINA ROHANI 等: "Flow through Horizontal Tubes Submerged in Water in the Absence", 《LANGMUIR》 * |
| MINA ROHANI 等: "Flow through Horizontal Tubes Submerged in Water in the Absence", 《LANGMUIR》, vol. 29, no. 22, 30 April 2013 (2013-04-30), pages 6556 - 6561 * |
| 周一 等: "排斥区研究综述", 《现代生物医学进展》 * |
| 周一 等: "排斥区研究综述", 《现代生物医学进展》, vol. 18, no. 9, 31 May 2018 (2018-05-31), pages 1785 - 1789 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102974410B (en) | Method and dedicated chip for preparation of micron calcium alginate filament based on microfluidic chip | |
| Wang et al. | Plugging properties and profile control effects of crosslinked polyacrylamide microspheres | |
| CN104389024B (en) | Method for preparing color-adjustable gel photonic crystal film | |
| Jeong et al. | Photothermal control of membrane permeability of microcapsules for on-demand release | |
| CN103275700A (en) | Method for preparing polymer fluorescent microsphere | |
| CN102757517B (en) | Method for preparing quick-responding thermo-sensitive porous microspheres based on microfluidic technology | |
| CN104829779B (en) | A kind of polymer microgel particle of photoresponse and preparation method thereof | |
| CN107629774A (en) | A kind of temporarily stifled diversion agent and preparation method thereof | |
| Moglia et al. | Solvent‐Free Fabrication of polyHIPE Microspheres for Controlled Release of Growth Factors | |
| CN103073679A (en) | Method for producing polyacrylamide microsphere water shutoff agent | |
| CN105218836A (en) | A kind of emulsifying agent assists biological enzyme to prepare the method for size tunable type starch nanometer granule | |
| CN110257958A (en) | A kind of vanadium nitride/carbon nano-fiber microwave absorption and preparation method thereof | |
| CN110371992B (en) | Method for synthesizing monodisperse silicon dioxide spheres by regulating microemulsion, and product and application thereof | |
| CN110057722A (en) | The experimental provision and experimental method of microballoon dispersity in a kind of adjustment mobile phase | |
| CN104072788B (en) | Method of preparing cellulose microspheres by multichannel microflow device | |
| CN104888670A (en) | Method for preparing natural polymer double-layer microcapsule through adoption of gas-liquid micro-channel | |
| CN106517219B (en) | Airsetting glueballs and preparation method thereof | |
| CN107151558A (en) | A kind of polymer stabilized nematic liquid crystals and preparation method thereof | |
| CN110272503A (en) | A kind of preparation method of the redispersible fiber type element nanofibrils of aqueous solution | |
| CN106048761A (en) | Encapsulated and networked regenerated cellulose phase-change fiber and preparation method thereof | |
| Yu et al. | Preparation and performance of green targeted microcapsules encapsulating surfactants | |
| CN106589249B (en) | A kind of preparation method of poly-dopamine/polyacrylic acid loading nano silvery composite material | |
| CN102659159A (en) | Method for preparing micron-granule composite nano calcium carbonate | |
| CN109929126A (en) | A kind of preparation method of the redisperse of water after drying type Nanowire cellulose | |
| CN104312594A (en) | Method for preparing chemical sand fixation agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |