CN110051691A - A kind of epoxy resin and cold compress patch having white-skinned face function - Google Patents

A kind of epoxy resin and cold compress patch having white-skinned face function Download PDF

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Publication number
CN110051691A
CN110051691A CN201810035228.2A CN201810035228A CN110051691A CN 110051691 A CN110051691 A CN 110051691A CN 201810035228 A CN201810035228 A CN 201810035228A CN 110051691 A CN110051691 A CN 110051691A
Authority
CN
China
Prior art keywords
epoxy resin
white
face function
skinned face
cold compress
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810035228.2A
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Chinese (zh)
Inventor
张劲松
朱礼飞
李保芝
张宇辰
张玉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhangjiagang Blue Zhi Biological Technology Co Ltd
Original Assignee
Zhangjiagang Blue Zhi Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhangjiagang Blue Zhi Biological Technology Co Ltd filed Critical Zhangjiagang Blue Zhi Biological Technology Co Ltd
Priority to CN201810035228.2A priority Critical patent/CN110051691A/en
Publication of CN110051691A publication Critical patent/CN110051691A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
    • A61F2007/0215—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
    • A61F2007/0219—Gels

Abstract

The invention discloses a kind of epoxy resin for having white-skinned face function, composition of raw materials is as follows: arbutin 0.1-4.5%；Nano-bioactive glass 0.3-10%；Nano titanium dioxide 0.1-2.5%；Niacinamide 0.1-3.5%；Medical glycerine 2.5-15.5%；Purified water 55.5-85.5%；Chitosan 0.8-2.0%；Sodium Hyaluronate 0.2-2.0%；Poloxamer 0.1-2.0%；Polyvinyl alcohol 1-10%.By above-mentioned, the epoxy resin and cold compress patch for having white-skinned face function of the invention, melanin production can be reduced, to reduce Skin pigmentation, have the effect of white-skinned face function and sterilization, anti-inflammatory, effectively keep moisture and fast filming, forms isolation environment, accelerate the infiltration of whitening composition, while mitigating the intolerance of niacinamide to avoid skin overstimulation.

Description

A kind of epoxy resin and cold compress patch having white-skinned face function
Technical field
The invention belongs to the field of medical product more particularly to a kind of epoxy resins and cold compress patch for having white-skinned face function.
Background technique
After facial skin is due to laser surgey or cold therapy, it is usually required to cold compress physical therapy, to reduce local skin Temperature, detumescence hemostasis mitigate the effect of pain, to reach alleviation or treat the expected purpose of disease.Although cold compress physical therapy is controlled Therapeutic effect is significant, but single effect, is easy stimulation skin, is not able to satisfy the demand of user.
Summary of the invention
The invention mainly solves the technical problem of providing a kind of epoxy resins for having white-skinned face function, can reduce melanin It generates, to reduce Skin pigmentation, has the effect of white-skinned face function and sterilization, anti-inflammatory, effectively keep moisture and quick Film forming forms isolation environment, accelerates the infiltration of whitening composition, while mitigating the intolerance of niacinamide to avoid skin excessive Stimulation.
In order to solve the above technical problems, one technical scheme adopted by the invention is that: it provides one kind and has white-skinned face function Epoxy resin, the composition of raw materials of the epoxy resin is as follows:
In a preferred embodiment of the present invention, the particle size of the nano-bioactive glass is 25-250nm, institute Stating nano-bioactive glass includes 3-30% calcium oxide and 10-70% silica.
In a preferred embodiment of the present invention, the particle size of the Nano titanium dioxide is in 85nm or less.
In a preferred embodiment of the present invention, the chitosan uses water soluble chitosan.
In order to solve the above technical problems, another technical solution used in the present invention is: providing one kind and have whitening function The cold compress patch of effect, including epoxy resin immerse the carrier cut in the epoxy resin after diluting several times, and re-disinfection packaging forms cold Application.
In a preferred embodiment of the present invention, the carrier is non-woven fabrics or silk fabric.
In a preferred embodiment of the present invention, the extension rate of the epoxy resin is 3-8 times.
The beneficial effects of the present invention are: a kind of epoxy resin and cold compress patch for having white-skinned face function of the invention, can be reduced Melanin production has the effect of white-skinned face function and sterilization, anti-inflammatory, effectively keeps moisture to reduce Skin pigmentation And fast filming, isolation environment is formed, the infiltration of whitening composition is accelerated, while mitigating the intolerance of niacinamide to avoid skin Skin overstimulation.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common Technical staff's all other embodiment obtained without making creative work belongs to the model that the present invention protects It encloses.
The embodiment of the present invention includes:
A kind of epoxy resin having white-skinned face function, the composition of raw materials of the epoxy resin are as follows:
Among the above, the particle size of the nano-bioactive glass is 25-50nm, the nano-bioactive glass Ingredient is mainly made of 3-30% calcium oxide and 10-70% silica and 2-10% phosphorus pentoxide etc.；The nanoscale The particle size of titanium dioxide is in 85nm or less.
In the present embodiment, the chitosan uses water soluble chitosan.
Epoxy resin is using polyvinyl alcohol, Sodium Hyaluronate, chitosan, poloxamer, purified water as the matrix material of epoxy resin Material, nanometer level bioactive glass, titanium dioxide, glycerol, arbutin, niacinamide etc. are that main functional component passes through special process Sterilization packaging is prepared.
The present invention also provides a kind of cold compress patchs for having white-skinned face function, including epoxy resin, and the carrier cut is immersed In epoxy resin after diluting several times, re-disinfection packaging forms cold compress patch.
Among the above, the carrier is non-woven fabrics or silk fabric, naturally it is also possible to select other carriers as needed.
Further, the extension rate of the epoxy resin is 3-8 times, and using effect is good.
Of the invention a kind of epoxy resin for having white-skinned face function and cold compress patch utilize " nano-bioactive glass, arbutin, Other core components of niacinamide " technological incorporation: such as poloxamer, water soluble chitosan CS, PVAC polyvinylalcohol, glycerol, hyalomitome Sour sodium HA is invented a kind of suitable for intact skin cold compress physical therapy and the whitening epoxy resin for preventing melanin from being formed and whitening cold compress Patch, the mechanism of action: by nanometer level bioactive glass it is non-stimulated dispersion and blocking action of ultraviolet radiation and chitosan it is good Biocompatibility long-acting bacteriostatic and increase osmotic pressure effect, the lightening mechanism of arbutin, niacinamide, glycerol, Sodium Hyaluronate Water retention.
Main feature:
1, arbutin inhibits the activity of internal TYR enzyme, prevents the generation of melanin, so that Skin pigmentation is reduced, It is provided simultaneously with sterilization, antiinflammation；
2, niacinamide (vitamin B3) can activate cyclic annular 3,5 nucleotide phosphodiesterase diesterases, so that stimulation melanin cell swashs 3,5 ring thuja acids of element are decomposed into adenine -5- monophosphate, reach reduction melanin production；
3, the addition of nano-bioactive glass can effectively prevent ultraviolet irradiation, and good dispersibility reduces black The generation of element；
4, increase minerals and osmotic pressure: the minerals such as the specific alkalescent of bioactivity glass and silicon, calcium, effective antiinflammatory With raising osmotic pressure, ideal osmotic condition is created, chitosan has good biocompatibility and certain bacteriostasis property；
5, it good water retention property: by the film forming of glycerol, the moisture retention of Sodium Hyaluronate and PVA, effectively keeps Moisture and fast filming form isolation environment, accelerate the infiltration of whitening composition；
5, improve niacinamide intolerance: the protection by water soluble chitosan, Sodium Hyaluronate and glycerol to skin, Niacinamide intolerance is effectively reduced, mitigates to skin irritatin.
In conclusion a kind of epoxy resin and cold compress patch for having white-skinned face function of the invention, can reduce melanin production, To reduce Skin pigmentation, have the effect of white-skinned face function and sterilization, anti-inflammatory, effectively keep moisture and fast filming, Isolation environment is formed, the infiltration of whitening composition is accelerated, while mitigating the intolerance of niacinamide to avoid skin overstimulation.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks Domain is included within the scope of the present invention.

Claims (7)

1. a kind of epoxy resin for having white-skinned face function, which is characterized in that the composition of raw materials of the epoxy resin is as follows:
2. the epoxy resin according to claim 1 for having white-skinned face function, which is characterized in that the nano-bioactive glass Particle size be 25-250nm, the nano-bioactive glass includes 3-30% calcium oxide and 10-70% silica.
3. the epoxy resin according to claim 1 for having white-skinned face function, which is characterized in that the Nano titanium dioxide Particle size is in 85nm or less.
4. the epoxy resin according to claim 1 for having white-skinned face function, which is characterized in that the chitosan is using water-soluble Chitosan.
5. having the cold compress patch of white-skinned face function described in one of -4 according to claim 1, which is characterized in that, will including epoxy resin The carrier cut immerses in the epoxy resin after diluting several times, and re-disinfection packaging forms cold compress patch.
6. the cold compress patch according to claim 5 for having white-skinned face function, which is characterized in that the carrier be non-woven fabrics or Silk fabric.
7. the cold compress patch according to claim 5 for having white-skinned face function, which is characterized in that the extension rate of the epoxy resin It is 3-8 times.
CN201810035228.2A 2018-01-15 2018-01-15 A kind of epoxy resin and cold compress patch having white-skinned face function Pending CN110051691A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810035228.2A CN110051691A (en) 2018-01-15 2018-01-15 A kind of epoxy resin and cold compress patch having white-skinned face function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810035228.2A CN110051691A (en) 2018-01-15 2018-01-15 A kind of epoxy resin and cold compress patch having white-skinned face function

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Publication Number Publication Date
CN110051691A true CN110051691A (en) 2019-07-26

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110436A (en) * 2020-01-08 2020-05-08 陕西盘龙药业集团股份有限公司 Nanometer quick-pasting cold compress gel, preparation method thereof and nanometer quick-pasting cold compress gel paste
CN111568885A (en) * 2020-06-14 2020-08-25 陕西健吉跃生物科技有限公司 Hydrogel patch containing nicotinamide and preparation method and application thereof
CN113827733A (en) * 2020-06-16 2021-12-24 深圳长久康联生物科技有限公司 Cold compress gel, and use method and application thereof
CN114504425A (en) * 2020-11-16 2022-05-17 湖北舒邦药业有限公司 Cold compress patch preparation method, cold compress patch and application method thereof
CN117180493A (en) * 2023-11-07 2023-12-08 中日友好医院(中日友好临床医学研究所) Composite hydrogel dressing and preparation method and application thereof

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110436A (en) * 2020-01-08 2020-05-08 陕西盘龙药业集团股份有限公司 Nanometer quick-pasting cold compress gel, preparation method thereof and nanometer quick-pasting cold compress gel paste
CN111110436B (en) * 2020-01-08 2022-08-19 陕西盘龙药业集团股份有限公司 Nanometer quick-pasting cold compress gel, preparation method thereof and nanometer quick-pasting cold compress gel paste
CN111568885A (en) * 2020-06-14 2020-08-25 陕西健吉跃生物科技有限公司 Hydrogel patch containing nicotinamide and preparation method and application thereof
CN113827733A (en) * 2020-06-16 2021-12-24 深圳长久康联生物科技有限公司 Cold compress gel, and use method and application thereof
CN114504425A (en) * 2020-11-16 2022-05-17 湖北舒邦药业有限公司 Cold compress patch preparation method, cold compress patch and application method thereof
CN117180493A (en) * 2023-11-07 2023-12-08 中日友好医院(中日友好临床医学研究所) Composite hydrogel dressing and preparation method and application thereof
CN117180493B (en) * 2023-11-07 2024-02-06 中日友好医院(中日友好临床医学研究所) Composite hydrogel dressing and preparation method and application thereof

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