CN110021357A - 模拟癌症基因组测序数据生成装置 - Google Patents
模拟癌症基因组测序数据生成装置 Download PDFInfo
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- CN110021357A CN110021357A CN201810256018.6A CN201810256018A CN110021357A CN 110021357 A CN110021357 A CN 110021357A CN 201810256018 A CN201810256018 A CN 201810256018A CN 110021357 A CN110021357 A CN 110021357A
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- 108700019961 Neoplasm Genes Proteins 0.000 title claims abstract description 67
- 102000048850 Neoplasm Genes Human genes 0.000 title claims abstract description 67
- 238000012163 sequencing technique Methods 0.000 title claims abstract description 42
- 238000004088 simulation Methods 0.000 claims abstract description 45
- 241000208340 Araliaceae Species 0.000 claims abstract description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 6
- 235000008434 ginseng Nutrition 0.000 claims abstract description 6
- 230000004927 fusion Effects 0.000 claims description 11
- 238000001514 detection method Methods 0.000 claims description 10
- 230000035772 mutation Effects 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 210000000349 chromosome Anatomy 0.000 claims description 6
- 238000012217 deletion Methods 0.000 claims description 6
- 230000037430 deletion Effects 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 5
- 238000003780 insertion Methods 0.000 claims description 5
- 230000037431 insertion Effects 0.000 claims description 5
- 238000011156 evaluation Methods 0.000 claims description 4
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000007689 inspection Methods 0.000 abstract description 6
- 206010069754 Acquired gene mutation Diseases 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 230000037439 somatic mutation Effects 0.000 description 2
- 241001269238 Data Species 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 230000003426 interchromosomal effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000036438 mutation frequency Effects 0.000 description 1
- 238000007481 next generation sequencing Methods 0.000 description 1
- 229940047431 recombinate Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 231100000427 somatic mutation induction Toxicity 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN2017114416586 | 2017-12-27 | ||
CN201711441658 | 2017-12-27 |
Publications (2)
Publication Number | Publication Date |
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CN110021357A true CN110021357A (zh) | 2019-07-16 |
CN110021357B CN110021357B (zh) | 2021-06-04 |
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CN201810256018.6A Active CN110021357B (zh) | 2017-12-27 | 2018-03-27 | 模拟癌症基因组测序数据生成装置 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111627492A (zh) * | 2020-05-25 | 2020-09-04 | 中国人民解放军军事科学院军事医学研究院 | 癌症基因组Hi-C数据仿真方法、装置和电子设备 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103299188A (zh) * | 2010-09-15 | 2013-09-11 | 阿尔玛克诊断有限公司 | 用于癌症的分子诊断试验 |
CN106202991A (zh) * | 2016-06-30 | 2016-12-07 | 厦门艾德生物医药科技股份有限公司 | 一种基因组多重扩增测序产物中突变信息的检测方法 |
CN106778065A (zh) * | 2016-12-30 | 2017-05-31 | 同济大学 | 一种基于多元数据预测dna突变影响蛋白互作的预测方法 |
US20170152570A1 (en) * | 2014-01-27 | 2017-06-01 | Dna-Seq, Inc. | Methods and systems for determination of an effective therapeutic regimen and drug discovery |
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2018
- 2018-03-27 CN CN201810256018.6A patent/CN110021357B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103299188A (zh) * | 2010-09-15 | 2013-09-11 | 阿尔玛克诊断有限公司 | 用于癌症的分子诊断试验 |
US20170152570A1 (en) * | 2014-01-27 | 2017-06-01 | Dna-Seq, Inc. | Methods and systems for determination of an effective therapeutic regimen and drug discovery |
CN106202991A (zh) * | 2016-06-30 | 2016-12-07 | 厦门艾德生物医药科技股份有限公司 | 一种基因组多重扩增测序产物中突变信息的检测方法 |
CN106778065A (zh) * | 2016-12-30 | 2017-05-31 | 同济大学 | 一种基于多元数据预测dna突变影响蛋白互作的预测方法 |
Non-Patent Citations (2)
Title |
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IGOR F. TSIGELNY等: "Molecular dynamics use in personalized cancer medicine: Example of MET Y501C mutation", 《2016 6TH INTERNATIONAL CONFERENCE ON SIMULATION AND MODELING METHODOLOGIES, TECHNOLOGIES AND APPLICATIONS (SIMULTECH)》 * |
秦颖等: "利用循环上皮细胞采集器捕获循环肿瘤细胞进行基因突变检测", 《医学理论与实践》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111627492A (zh) * | 2020-05-25 | 2020-09-04 | 中国人民解放军军事科学院军事医学研究院 | 癌症基因组Hi-C数据仿真方法、装置和电子设备 |
CN111627492B (zh) * | 2020-05-25 | 2023-04-28 | 中国人民解放军军事科学院军事医学研究院 | 癌症基因组Hi-C数据仿真方法、装置和电子设备 |
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