CN110013610A - A kind of optical heating device based on imaging - Google Patents
A kind of optical heating device based on imaging Download PDFInfo
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- CN110013610A CN110013610A CN201910358937.9A CN201910358937A CN110013610A CN 110013610 A CN110013610 A CN 110013610A CN 201910358937 A CN201910358937 A CN 201910358937A CN 110013610 A CN110013610 A CN 110013610A
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- imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Radiation-Therapy Devices (AREA)
Abstract
The present invention discloses a kind of optical heating device based on imaging, comprising: the optical imaging assemblies for object illumination region to be imaged, projecting subassembly, heated light sources and control device for carrying out light irradiation to irradiation area；Optical imaging assemblies are electrically connected by means of imaging device with control device, and projecting subassembly is electrically connected with the control device；Light on object illumination region is via being imaged the image for obtaining targeted imaging region in an imaging device after optical imaging assemblies；The image in object illumination region, described image are transmitted to the control device；Control device needs the parts of images heated according to image selection part, and the projecting subassembly is controlled according to the parts of images of selection, so that projecting subassembly heats the heating light of heated light sources along the imaging optical path backtracking of optical imaging assemblies to correspond to object area to the parts of images of selection.Above-mentioned device can be applied to medical treatment, physical therapy and beauty treatment fields, using safely controllable and at low cost.
Description
Technical field
The invention belongs to medical device fields, and in particular to a kind of optical heating device based on imaging.
Background technique
Photo-thermal effect is widely used in fields such as medicine, rehabilitation, beauty, in tumor thermotherapy, laser photocoagulation, reason
It treats and promotes regeneration, wrinkle-removal cosmetic, there is extensive application in the fields such as meridian point irradiation treatment.In such applications, illumination
Controllability be the biggest problem always.
Thermotherapy is that hyperthermia is used for the treatment method of the diseases such as tumour.High temperature can make cell death.When temperature rises
When to 42 DEG C or more, thermal energy starts to make the cell of people to be damaged.Thermal energy to the degree of cellular damage depend on temperature height and
Action time, this phenomenon are especially apparent tumour cell.Modern thermotherapy is using instrument, by illumination, ultrasound, micro-
The temperature at some position of human body or organ is increased to the medicative level of tool, reaches kill part by the modes such as wave, radio frequency
The treatment method of tumour.The mechanism for killing tumour is not entirely clear that in addition to thermotherapy direct killing, dead pathological tissues are broken
Piece may also have immune activation and reinforcing effect.Currently, thermotherapy is more as a kind of auxiliary in the clinical treatment of tumour
Treatment means are helped, are used with chemoradiotherapy plus, therapeutic effect is promoted.
Thermotherapy development major technology bottleneck first is that heat transmitting it is non-selective, this is easily caused around destination organization
Normal tissue organ damage.Current resolution policy is the photo-thermal reinforcer that exploitation can be assembled in photothermal target regioselectivity
Matter.In use, carrying out illumination to whole visual field, there is the part of photo-thermal enhancing material that there is higher photothermal conversion efficiency, thus
Realize selective photothermolysis therapeutic purposes.But this mode, which has, to be had disadvantages that: firstly, the safety of photo-thermal enhancing material is a hardly possible
Topic.The most photo-thermal enhancing materials reported at present all have toxic side effect, are the metabolism device of body when especially dosage is higher
Official, such as liver, kidney etc. bring risk and burden.Secondly, photo-thermal enhancing material is difficult to realize the specificity intake of target area.
And the intake other than any target area all brings the risk of damage healthy tissues and organ for photo-thermal therapy.
Summary of the invention
For problem of the prior art, the present invention provides a kind of optical heating device based on imaging.
To achieve the above object, the main technical schemes that the present invention uses include:
The present invention provides a kind of optical heating device based on imaging, comprising:
Optical imaging assemblies for object illumination region to be imaged, the throwing for carrying out light irradiation to irradiation area
Shadow component, heated light sources and control device；
The optical imaging assemblies are electrically connected by means of imaging device with control device, the projecting subassembly and the control
Device electrical connection；
Light on the object illumination region obtains object illumination via being imaged after optical imaging assemblies in an imaging device
The image in region, described image are transmitted to the control device；
The control device needs the parts of images heated, and the part figure according to selection according to described image selected section
As controlling the projecting subassembly, so that projecting subassembly is by the heating light of heated light sources along the imaging of the optical imaging assemblies
Road backtracking is heated with corresponding to object area to the parts of images of selection.
Optionally, the projecting subassembly includes: to be connect with the control device using high-penetration formula high temperature polysilicon system
The liquid crystal light valve of work or the digital light processing component being connect with control device.
Optionally, the optical imaging assemblies include:
Receive the first lens/first lens group of the visible light and black light on object illumination region；
Positioned at the first lens/first lens group at the light splitting member for being transmissive to imaging ray and reflecting heating light of image side
Part；
Positioned at the first lens/first lens group at image side, and to the optical filtering that the transmitted light of beam splitter filters
Element；
For to the third lens converged via the imaging after filter element/the third lens group；
The second lens for the light of projecting subassembly converge/be dissipated into beam splitter in heating optical path/
Second lens group.
Optionally, the optical imaging assemblies include:
It receives and to the visible light and the filter element that filters of black light on object illumination region；
For to the third lens converged via the imaging after filter element/the third lens group；
In heating optical path for converge/be dissipated into the second of object heating region thoroughly for the light of projecting subassembly
Mirror/the second lens group.
Optionally, described device includes one or more groups of projecting subassemblies and multiple heated light sources；
The corresponding heated light sources of each group of projecting subassembly.
Optionally, the imaging device is in visual light imaging camera, black light image camera and thermal imaging camera
One or more combinations.
Optionally, the image that the projecting subassembly can be obtained according to the imaging device, by heating light projection to object
Some or all of upper corresponding described image region, wherein when projecting subassembly uses liquid crystal light valve, liquid crystal light valve should be used
The production of high-penetration formula high temperature polysilicon.
It optionally, further include shell；The optical imaging assemblies, projecting subassembly, heated light sources and imaging device are respectively positioned on
In shell, and meet optical imaging concept in the intracorporal position of shell.
The beneficial effects of the present invention are:
By the image in the object illumination region that imaging device obtains, then manually or automatically identification is carried out to described image and is selected
It selects, so as to the object area for being heated the needs that the light of heated light sources projects to selection using projecting subassembly, realizes selectively
Target area is heated, the damage to tissue and organ other than target is avoided.
Liquid crystal light valve or similar functions component have stronger controllability in projecting subassembly of the invention, can be realized and add
The light intensity of the real-time of hot light, high-resolution and full field range freely regulates and controls.With the cooperation of optical imaging assemblies and projecting subassembly
It uses, can be realized real-time illumination adjustment.
The device of the application is applied to eliminate the reliance on photo-thermal enhancing material when the photo-thermal irradiation in specified region.Utilize optics side
Method realizes the selective light thermal effect of target area, so that photo-thermal heating means is eliminated the reliance on photo-thermal enhancing material, avoids photo-thermal
Toxic side effect caused by enhancing material.
Due to not needing photo-thermal enhancing material in the application, and then the light source selection of photo-thermal is no longer influenced by photo-thermal enhancing material
The restriction of characteristic absorption spectrum.Conventionally, as different material has its characteristic absorption spectrum, photo-thermal reinforcer is used
When the photo-thermal therapy of matter/photo-thermal heating, it has to select the heated light sources of specific wavelength.The present invention is then according to tissue and organ
Characteristic unrestricted choice heated light sources.It can according to need the photo-thermal heating light that selection directive property is good, the thermal efficiency is high, penetration depth is big
Source.
The heating problem of non-uniform of photo-thermal irradiation can also be solved when the device application of the application.Pass through real-time optical and heat
Imaging analysis realizes the heating effect of target area uniform, controllable.Irradiation is reduced for the high-temperature part of target area, is increased simultaneously
The irradiation of strong low temperature part.By the Real-time Feedback of imaging, target area is made to meet heating standard, while ensureing nontarget area
In safe temperature range.
In addition, using a variety of light path design schemes in the present invention, both light irradiation light can be heated using shared optical path scheme
Road is overlapped with imaging optical path, solves the accurate contraposition problem of the two from hardware, is established for the realization of accurate photo-thermal therapy/heating
Basis is determined, or optical path is respectively set with heating light in imaging, in order to which multiple light courcess irradiates a target simultaneously, in target
Position achievees the effect that focusing illumination.
Illumination heating in the application can follow target in real time.This is because heating illumination can carry out in fact according to imaging
When adjust, realize only in image selection area implement irradiation.The realization of the function need to only guarantee that illuminated target is located always
In visual field, the relative position for strictly fixing illuminated object and irradiation unit is not needed.This is photo-thermal therapy/heating
Implementation offer convenience, and ensure the safety of illumination.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram for optical heating device based on imaging that the embodiment of the present invention 1 provides；
Fig. 2 is a kind of structural schematic diagram for optical heating device based on imaging that the embodiment of the present invention 2 provides；
Fig. 3 is a kind of structural schematic diagram for optical heating device based on imaging that the embodiment of the present invention 3 provides.
Specific embodiment
In order to better explain the present invention, in order to understand, with reference to the accompanying drawing, by specific embodiment, to this hair
It is bright to be described in detail.
Embodiment 1
The present embodiment provides a kind of optical heating devices based on imaging, specifically as shown in Figure 1, the device packet of the present embodiment
It includes: optical imaging assemblies, imaging device, heated light sources, projecting subassembly；
Wherein, optical imaging assemblies obtain object in imaging device such as camera for object illumination region to be imaged
The image of body irradiation area, imaging device such as camera can be by image transmittings to control device.
At this point, control device can image selection part based on imaging device or all images as subsequent heat light source
The region heated.
It illustrates, the imaging of optical imaging assemblies can be the visual light imaging to object illumination region, can also
To be that the black light in object illumination region is imaged, the present embodiment does not limit it, adjusts according to actual needs.
Projecting subassembly is electrically connected with control device, and the penetrating region of the instruction adjustment projecting subassembly of receiving control device makes
Projecting subassembly by the heating light of heated light sources along the imaging optical path backtracking of the optical imaging assemblies to selection
Parts of images corresponds to object area and is heated.
Imaging device in the present embodiment can be visual light imaging camera, black light image camera and thermal imaging camera
Culture transferring or multiple combinations be configured in practical applications according to imaging demand, be not limited.
As shown in Figure 1, the projecting subassembly of the present embodiment can are as follows: the liquid crystal light valve being connect with the control device.Specifically,
Liquid crystal light valve is to be made of high-penetration formula high temperature polysilicon (High TemperaturePoly-Silicon, HTPS), from meter
The penetrating region for the image analysis control signal control liquid crystal light valve that calculation machine, that is, control device transmission comes, heated light sources are irradiated in liquid
Brilliant light valve, only the light of transparent region can be irradiated in after the beam splitter reflection in optical imaging assemblies by liquid crystal light valve
The target area of object, and then realize the accurate photo-thermal irradiation of imaging guidance.
The optical imaging assemblies of the present embodiment include: the first lens, beam splitter, filter element, the second lens and third
Lens.
Wherein, the first lens are used to receive the visible light and/or black light in object illumination region；
Beam splitter be located at the first lens at image side, and be transmissive to the imaging ray after the first lens and radiotherapy
Light/heating light；For example, the beam splitter of the present embodiment can be for Amici prism or beam splitter based on wavelength or based on polarization
Polarization spectroscope.
Filter element be located at the first lens at image side, and to the optical filtering member that the transmitted light of beam splitter filters
Part；
The third lens are used for carrying out converging to imaging device via the imaging after filter element；The imaging of the present embodiment
Equipment can be located at the imaging region after the third lens, and such as one times of focal length is between two focus length.Beam splitter above-mentioned and optical filtering
Element is both needed between imaging device and the first lens.Second lens are located in heating optical path, for by the light of projecting subassembly
Converge/it is dissipated into beam splitter.
In practical applications, it is preferably imaging, excitation light source can be increased in object illumination areas adjacent and carry out fluorescence
Imaging, also can be used natural light, it is therefore an objective to and optical imaging assemblies are preferably imaged object illumination region,
The present embodiment does not limit it, adjusts according to actual needs.
Specifically, the excitation light source of fluorescence imaging is irradiated in target object or tissue, due to target area in illuminated tissue
Domain and normal tissue generate the image comparison of target area and normal tissue, this figure for the intake difference of fluorescent imaging drug
As passing through imaging lens group, the imaging unit of camera is transmitted to by beam splitter and filter element, filter element stops excitation
Light source, through the light beam of fluorescence bands.Picture signal is passed to computer by camera, computer carry out image display storage and
Analysis (analysis can be realized automatically or artificially be selected), using analysis result control liquid crystal light valve in turn by the heating light of heated light sources
It is irradiated to object tissue corresponding to the image of selection region.
Above structure realizes optical imagery and thermal imaging to the target visual field, realizes being precisely controlled for heating light.
Embodiment 2
The present embodiment provides a kind of optical heating devices based on imaging, specifically as shown in Fig. 2, the device packet of the present embodiment
It includes: optical imaging assemblies, camera, heated light sources, projecting subassembly.
The present embodiment 2 the difference from embodiment 1 is that: projecting subassembly is different, and the projecting subassembly of the present embodiment is and control
Digital light processing (Digital Light Processing, DLP) component of device connection, as shown in Figure 2.
Computer/control device picture signal reaches DLP controller, the high-resolution digital micro mirror in DLP component
(DMD) it receives the signal of DLP controller and changes the angle of micro mirror in DLP component, realize the light reflection controlled by function image,
The reflected light of heating light is irradiated in target area through lens group and beam splitter, realizes accurate photo-thermal irradiation.
In this implementation, based on computer/control device selection parts of images to be heated, DMD carries out projection light source
There is the reflection of resolution ratio, realizes that heating light precisely projects the corresponding object/tissue of parts of images of selection, and then realize essence
Quasi- photo-thermal irradiation.
Embodiment 3
The present embodiment provides a kind of optical heating devices based on imaging, specifically as shown in figure 3, the device packet of the present embodiment
It includes: optical imaging assemblies, imaging device such as camera, multiple heated light sources, multiple projecting subassemblies.Each projecting subassembly corresponding one
A heated light sources.
The difference of the present embodiment and previous embodiment is that the projecting subassembly of the present embodiment is to connect with the control device
High temperature polysilicon liquid crystal display.
The optical imaging assemblies of the present embodiment include: reception and the visible light to object illumination region and black light carry out
The filter element of optical filtering；
For to the third lens converged via the imaging after filter element；
It is used to carry out the light of projecting subassembly to converge/be dissipated into the second of region to be illuminated in photo-thermal illumination path
Lens.
It illustrates, the object in above three embodiments can be tissue, be used for human body target group
The imaging knitted, and then the manually or automatically target area corresponding to selection target tissue in control device, and then using projection
Component carries out the specified region for precisely projecting to destination organization to the light of heated light sources, realizes that accurately photo-thermal irradiates, and subtracts simultaneously
The use of few photo-thermal enhancing material in the prior art, avoids the toxic side effect that photo-thermal enhancing material may cause, improves and control
Treatment/heating safety, and be conducive to the realization of therapeutic effect.
It illustrating, the various components in above three embodiments are respectively positioned in shell, that is, belong in a shell,
Its imaging device can be connect with the control device of hull outside, and optical heating device in use uses portable devices as a result,.Shell
Interior the location of each component meets light image-forming principle, and can accurately realize the imaging of optical path.
Above three embodiments may be implemented to carry out optical imagery and thermal imaging to the target visual field.It is needed in selection image
The region of heating controls liquid crystal light valve or DMD digital micromirror, generates transmission or reflection to heating light.For example, heating
Light penetrates the transparent part in liquid crystal light valve, or heating light is reflected by DLP component, is irradiated in destination organization.
The temperature that destination organization can be monitored during thermal imaging in real time adjusts liquid crystal light valve or DMD according to heating effect
Digital micromirror and heating light, to realize the thermotherapy of controllable precise.
The camera section of the present embodiment is divided into imaging device, may include visual light imaging camera, black light camera and heat
Image camera etc., compatible common various polyphaser imaging design schemes.
It is to be appreciated that describing the skill simply to illustrate that of the invention to what specific embodiments of the present invention carried out above
Art route and feature, its object is to allow those skilled in the art to can understand the content of the present invention and implement it accordingly, but
The present invention is not limited to above-mentioned particular implementations.All various changes made within the scope of the claims are repaired
Decorations, should be covered by the scope of protection of the present invention.
Claims (8)
1. a kind of optical heating device based on imaging characterized by comprising
Optical imaging assemblies for object illumination region to be imaged, the projection group for carrying out light irradiation to irradiation area
Part, heated light sources and control device；
The optical imaging assemblies are electrically connected by means of imaging device with control device, the projecting subassembly and the control device
Electrical connection；
Light on the object illumination region obtains object illumination region via being imaged after optical imaging assemblies in an imaging device
Image, described image are transmitted to the control device；
The control device needs the parts of images heated, and the parts of images control according to selection according to described image selected section
The projecting subassembly is made, so that projecting subassembly is former along the imaging optical path of the optical imaging assemblies by the heating light of heated light sources
Road returns and is heated with corresponding to object area to the parts of images of selection.
2. the apparatus according to claim 1, which is characterized in that
The projecting subassembly includes: the liquid crystal light valve made of high-penetration formula high temperature polysilicon connecting with the control device
Or the digital light processing component being connect with control device.
3. the apparatus according to claim 1, which is characterized in that the optical imaging assemblies include:
Receive the first lens/first lens group of the visible light and black light on object illumination region；
Positioned at the first lens/first lens group at the beam splitter for being transmissive to imaging ray and reflecting heating light of image side；
Positioned at the first lens/first lens group at image side, and to the filter element that the transmitted light of beam splitter filters；
For to the third lens converged via the imaging after filter element/the third lens group；
The second lens/the second for being used to converge/be dissipated by the light of projecting subassembly beam splitter in heating optical path
Lens group.
4. the apparatus according to claim 1, which is characterized in that the optical imaging assemblies include:
It receives and to the visible light and the filter element that filters of black light on object illumination region；
For to the third lens converged via the imaging after filter element/the third lens group；
The second lens for the light of projecting subassembly converge/be dissipated into object heating region in heating optical path/
Second lens group.
5. the apparatus according to claim 1, which is characterized in that described device includes one or more groups of projecting subassemblies and multiple
Heated light sources；
The corresponding heated light sources of each group of projecting subassembly.
6. the apparatus according to claim 1, which is characterized in that
The imaging device is one of visual light imaging camera, black light image camera and thermal imaging camera or a variety of groups
It closes.
7. the apparatus of claim 2, which is characterized in that the projecting subassembly can be obtained according to the imaging device
Image, will heating light projection to object on correspond to some or all of described image region, wherein when projecting subassembly use liquid
When brilliant light valve, liquid crystal light valve should be made of high-penetration formula high temperature polysilicon.
8. device according to any one of claims 1 to 7, which is characterized in that further include shell；
The optical imaging assemblies, projecting subassembly, heated light sources and imaging device are respectively positioned in shell, and in the intracorporal position of shell
Meet optical imaging concept.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910358937.9A CN110013610A (en) | 2019-04-30 | 2019-04-30 | A kind of optical heating device based on imaging |
| PCT/CN2019/095094 WO2020220470A1 (en) | 2019-04-30 | 2019-07-08 | Imaging-based light heating apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910358937.9A CN110013610A (en) | 2019-04-30 | 2019-04-30 | A kind of optical heating device based on imaging |
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| Publication Number | Publication Date |
|---|---|
| CN110013610A true CN110013610A (en) | 2019-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910358937.9A Pending CN110013610A (en) | 2019-04-30 | 2019-04-30 | A kind of optical heating device based on imaging |
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| CN (1) | CN110013610A (en) |
| WO (1) | WO2020220470A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204709655U (en) * | 2015-02-03 | 2015-10-21 | 北京理工大学 | A kind of precisely blood vessel photodynamic treatment device |
| WO2016172312A1 (en) * | 2015-04-24 | 2016-10-27 | Rush University Medical Center | Radiation therapy system and methods of use thereof |
| CN106139408A (en) * | 2016-08-13 | 2016-11-23 | 魏伯卿 | Microwave positioning heating cancer treating instrument |
| CN107049254A (en) * | 2017-04-05 | 2017-08-18 | 展谱光电科技（上海）有限公司 | Portable multiple spectrum is imaged and projection arrangement and method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5311568A (en) * | 1992-05-01 | 1994-05-10 | Picker International, Inc. | Optical alignment means utilizing inverse projection of a test pattern/target |
-
2019
- 2019-04-30 CN CN201910358937.9A patent/CN110013610A/en active Pending
- 2019-07-08 WO PCT/CN2019/095094 patent/WO2020220470A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204709655U (en) * | 2015-02-03 | 2015-10-21 | 北京理工大学 | A kind of precisely blood vessel photodynamic treatment device |
| WO2016172312A1 (en) * | 2015-04-24 | 2016-10-27 | Rush University Medical Center | Radiation therapy system and methods of use thereof |
| CN106139408A (en) * | 2016-08-13 | 2016-11-23 | 魏伯卿 | Microwave positioning heating cancer treating instrument |
| CN107049254A (en) * | 2017-04-05 | 2017-08-18 | 展谱光电科技（上海）有限公司 | Portable multiple spectrum is imaged and projection arrangement and method |
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