CN109985579A - Mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material and preparation method thereof - Google Patents
Mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material and preparation method thereof Download PDFInfo
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Abstract
The present invention provides mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material and preparation method thereof, after preparing the wet gel and montmorillonite wet gel that carbon nanotube carries dexamethasone respectively, after the two is mixed with gentamycin solution, mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material is made.With gradually increasing for soaking time, the drug gentamicin being carried in mesoporous takes the lead in discharging, and with further increasing for soaking time, the subsequent release of dexamethasone drug being carried in micropore realizes primary medication, the effect of multiple dosing.
Description
Technical field
The present invention relates to technical field of nano material, more specifically to the mesoporous-micropore carbon nanotube-Meng Tuo of one kind
Native aerogel composite and preparation method thereof.
Background technique
Montmorillonite (MMT) is a kind of electronegative silicate lamella in surface by nano thickness (about 1nm) by interlayer
Electrostatic interaction and the earthy mineral for being packed together composition.Structure cell in its crystal structure is by folder among two layers of oxygen-octahedron
One layer of alumina octahedral is constituted, and belongs to 2:1 type phyllosilicate.(the organically-modified research of Xie Youli, Zhang Meng, Zhou Yonghong montmorillonite
Be in progress [J] chemical industry progress, 2012, (04): 844-851.) structure cell in its crystal structure is by among two layers of oxygen-octahedron
It presss from both sides one layer of alumina octahedral to constitute, belongs to 2:1 type phyllosilicate.This special crystal structure assigns the unique property of montmorillonite
Matter, such as surface polarity is big, cation exchange capacity (CEC) is strong, interlayer surface is aqueous.
The thickness of every layer of montmorillonite is about 1nm, and respectively about 100nm, interlamellar spacing are about 1nm or so to length and width.Due to montmorillonite
Part trivalent aluminium makes layer inner surface have negative electrical charge by divalent magnesium isomorphous substitution on alumina octahedral, and superfluous negative electrical charge passes through
The cation of Inter layer adsorption compensates, they are easy to swap with inorganic or organic cation.(Zhou Chunhui, Cai Ye, sieve tin
It is flat, Ge Zhonghua, Li little Nian, the alkylation performance and structural research [J] high of Liu Huayan montmorillonite load type solid acid catalyst
School chemical engineering journal, 2003, (01): 96-100.) montmorillonite after organic cation exchange is in lipophilicity, and interlayer
Distance increases.Organic modification montmonrillonite can be removed further during with monomer or Mixing of Polymer Melt as nanometer ruler
The frame sheet of degree, it is evenly dispersed in a polymer matrix, to form nanocomposite.
Montmorillonite-based nano pipe has unique nanostructure, is a kind of natural nano-material having a extensive future.And montmorillonite
Nanotube is widely distributed, cheap, nontoxic.Montmorillonite because of its unique nanostructure, have the advantage that firstly,
It is from a wealth of sources, it is cheap；Montmorillonite is a kind of natural clay mineral, contain it is abundant, it is widely distributed and exploitation be easier to.Secondly,
With good biocompatibility；Montmorillonite-based nano pipe self-assembling formation, nontoxic, biocompatibility is preferable.In addition, active hydroxyl
Base is contained in montmorillonite surface and interlayer, conducive to montmorillonite modification and further apply.Along with itself has nanometer ruler
The features such as spending, montmorillonite have obtained extensive concern and research in recent years.
The application field of montmorillonite-based nano pipe is extensive.In ceramic material, composite material, slow-release material, catalyst carrier, mould
Plate, adsorption applications etc. have a large amount of application.Because montmorillonite-based nano pipe is a kind of clay mine, it can be used for ceramic system
Make, this belongs to traditional application field of montmorillonite.Montmorillonite has the function of fiber reinforcement, is the ideal for preparing ultra-thin fine ceramics
Raw material.In recent years, the research of galapectite/polymer composites and its performance was becoming increasingly popular.Montmorillonite can be
Preferably disperse in most polymer composite material, mechanical property, thermal stability, anti-flammability and the knot of polymer can be effectively improved
Brilliant performance, having biggish advantage compared with other conventional fillers, (Ma Jianzhong, Chen Xinjiang, Chu Yun, the remote montmorillonite-based nano of poplar ancestor are multiple
Preparation and application study [J] Chinese leather of condensation material, 2002, (21): 15-20.).Montmorillonite has unique texture, environment
The features such as friendly, cheap and easy to get, can prepare the material with new structure and performance using its design feature and characterization of adsorption,
It is widely used in field of nanocomposite materials.
Summary of the invention
The present invention overcomes deficiencies in the prior art, provide a kind of mesoporous-micropore carbon nanotube-montmorillonite Composite gas
Gel rubber material and preparation method thereof uses the doughnut with microcellular structure for raw material, builds three-dimensional aeroge network, utilizes
The meso-hole structure of aeroge and the microcellular structure of fiber, load different pharmaceutical respectively, realize the ladder-like classification release of drug.
The purpose of the present invention is achieved by following technical proposals.
Mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material and preparation method thereof carries out as steps described below:
Step 1,0.5-15 parts by weight lauryl sodium sulfate (SDS), 0.01-20 parts by weight dexamethasone is taken to be added 100
In parts by weight water, after sonic oscillation is uniform, the carbon nanotube of 0.5-15 parts by weight is added thereto, after ultrasonic disperse is uniform, takes out
Vacuum is kept after vacuum, is then restored to normal pressure, is repeated vacuum step three times, is obtained the wet gel of step 1；
Step 2, by after 0.05-15 parts by weight montmorillonite drying, dispersed with the montmorillonite that solvent is configured to 0.05-25wt%
Liquid, montmorillonite dispersions mechanical stirring is uniform, after being then sonicated, obtain the wet gel of step 2；
Step 3, by the wet gel of 0.5-35 parts by weight step 1, the wet gel of 0.5-30 parts by weight step 2,0.1-20 weight
It measures the gentamycin solution that part mass fraction is 0.05-20wt% to mix, stirs evenly after being then sonicated centrifugation, produced
Object, place the product in CO2In supercritical high-pressure extraction device, with CO2It is medium at 10-300 DEG C of temperature and air pressure 1-20MPa
Supercritical drying at least 1h is carried out, mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material can be obtained.
In step 1, water is added in 1-10 parts by weight lauryl sodium sulfate (SDS), 0.05-15 parts by weight dexamethasone
In, after sonic oscillation 2-48h, the carbon nanotube of 1-10 parts by weight is added thereto, after ultrasonic disperse 1-24h, is protected after vacuumizing
Hold 1h.
In step 2, the montmorillonite of 0.1-10 parts by weight is dried to 5-20h at 60-180 DEG C, is configured to 0.1- with solvent
Montmorillonite dispersions are stirred 4- at 5-35 DEG C with the speed mechanical of 150-400r/min by the montmorillonite dispersions of 20wt%
10h, then the ultrasonic treatment 6-15h with 50-300W power.
In step 3,1-30 parts by weight of carbon nanotubes is carried into medicine wet gel, 1-30 parts by weight montmorillonite wet gel, 0.5-
The gentamycin solution that 15 parts by weight mass fractions are 0.05-15wt% mixes, and 10-25h is stirred at 5-35 DEG C, is ultrasonically treated
6-15h is finally centrifuged 1-8h under 1000-3500rpm revolving speed.
In step 3, the supercritical drying time is 2-4h, preferably 3h.
The dexamethasone being added in step 1 is dispersed in carbon nanotube hollow structure, and carbon nanotube hollow structure is to be situated between
Hole-micropore carbon nanotube-montmorillonite Composite aerogel material provides microcellular structure, and dexamethasone is supported in carbon nanotube,
Forming tridimensional network between carbon nanotube, the montmorillonite being added in step 2 is successfully configured to network pore structure, and above-mentioned three
Dimension reticular structure and carbon nanotube are successfully configured to network pore structure and together form three-dimensional network pore structure, above-mentioned three-dimensional
Network pore structure provides meso-hole structure for mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material, while will celebrate big mould
Element is supported in meso-hole structure.
Using scientific and technological (Beijing) the Co., Ltd 3H-2000PS1 type static volumetric method specific surface area of Bei Shide instrument and aperture
The N of the tester analysis composite material that according to the present invention prepared by the method2Adsorption-desorption curve, such as attached drawing 1.It can from figure
To find out, the N of the material2Adsorption-desorption curve is the IV class isothermal curve of H1 type hysteresis loop in IUPAC classification, i.e., by mesoporous
Structure generates.Illustrate that material itself has the pore structure of meso-scale.There is vertical ascent trend from the distribution of low pressure endpoint, it can be with
Sample interior is found out there are more micropore, is as caused by absorption potential strong inside micropore.By nitrogen adsorption desorption isotherm number
According to the sample specific surface area can reach 602.14m2g-1, which exists simultaneously mesoporous-micropore second level pore structure, through more
The average specific surface area of group measurement material is 600-608m2g-1。
By N2Data in adsorption-desorption curve are substituted into correlation values, can be arranged by BJH formula and Kelvin equation
Obtain the accounting equation r in aperturek=-0.964/ln (p/p0), unit nm, while adding adsorbent layer thickness t=0.362 [- 5/
ln(p/p0)] ^ (1/3), can obtain effective aperture is r=rk+ t, therefore aperture is the function influenced by relative pressure, so may be used
In the hope of the aperture under different relative pressures, it can calculate and acquire in material that there are two aperture points to be distributed, Yi Zhongwei
10.38nm, another kind are 20.41 μm, are measured through multiple groups, and nanoscale hole is average up to 10-12nm, and micro-meter scale hole is flat
Up to 20-22 μm.It can be seen that material exists simultaneously nanoscale and micro-meter scale hole.
Using the Nanosem430 field emission scanning electron microscope of Dutch Philips to the method for the invention system of utilization
The microscopic appearance of standby composite material is observed, as shown in Figure 2.It can be seen from the figure that montmorillonite layer is successfully configured to
Network pore structure, aperture size is in mesoporous scale.It is overlapped to form three-dimensional netted carbon nanotube and is uniformly dispersed in montmorillonite three
It ties up in network pore, realizes the building of dual load system.
Reference literature (Li Degui, the preparation and characterization of nano-cellulose base Thermosensitive Material Used for Controlled Releasing of Medicine, South China Science & Engineering University,
2016) method described in carries out sustained release performance test characterization to material prepared by the present invention.Two sustained release steps are delayed respectively
It releases product and carries out infrared spectroscopy detection, as a result as shown in figure 3, by being compareed with standard diagram, it was demonstrated that take the lead in release is that celebrating is big
Mycin, what is then discharged is dexamethasone, realizes the multiple dimensioned load and repeatedly release of different pharmaceutical.
The composite material carrying medicament prepared using the method for the invention is placed in simulation human consumption's liquid, measurement
Its drug release effect, figure 4, it is seen that gradually increasing with soaking time, fills in the drug being carried in mesoporous
Meter Song takes the lead in discharging, and with further increasing for soaking time, the subsequent release of gentamicin drug being carried in micropore is realized
Primary medication, the effect of multiple dosing.
Detailed description of the invention
Fig. 1 is mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material N2Adsorption-desorption curve；
Fig. 2 is mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material electromicroscopic photograph；
Fig. 3 is mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material release product test curve；
Fig. 4 is mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material carrying medicament release profiles.
Specific embodiment
Below by specific embodiment, further description of the technical solution of the present invention.
Embodiment 1
Take 1g lauryl sodium sulfate (SDS), 10g dexamethasone be added 100g water in, sonic oscillation for 24 hours after, be added 5g
Carbon nanotube, ultrasonic disperse 5h obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to normal pressure, weight
Multiple vacuum step three times, obtains carbon nanotube and carries medicine wet gel；10h is dried into 0.5g montmorillonite at 78 DEG C, then uses solvent
It is configured to the montmorillonite dispersions that mass fraction is 6wt%；By montmorillonite dispersions with the speed machine of 190r/min at 26 DEG C
Tool stirs 5h, then with the ultrasonic treatment 11h of 150W power, obtains montmorillonite wet gel；By 12g carbon nanotube carry medicine wet gel,
21g montmorillonite wet gel, the gentamycin solution that 0.5g mass fraction is 5.9wt% mix, and 19h, then ultrasound are stirred at 8 DEG C
6h is handled, 8h is finally centrifuged under 1200rpm revolving speed, obtains solution, then place the product in CO2Supercritical high-pressure extraction device
In, with CO2Supercritical drying 3h is carried out at 150 DEG C of temperature and air pressure 10MPa for medium, and carbon nanotube/montmorillonite can be obtained
Multiple dimensioned load medicine aeroge.
Embodiment 2
It takes 5g lauryl sodium sulfate (SDS), 5g dexamethasone to be added in 100g water, after sonic oscillation 2h, is added 3g's
Carbon nanotube, ultrasonic disperse 1h, obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, is then restored to normal pressure, is repeated
Vacuum step three times, obtains carbon nanotube and carries medicine wet gel；7h is dried into 5g montmorillonite at 155 DEG C, then is configured with solvent
The montmorillonite dispersions for being 2wt% at mass fraction；Montmorillonite dispersions are stirred at 35 DEG C with the speed mechanical of 400r/min
It mixes 4h, then with the ultrasonic treatment 9h of 288W power, obtains montmorillonite wet gel；13g carbon nanotube is carried into medicine wet gel, 10g is covered
De- soil wet gel, the gentamycin solution that 12g mass fraction is 3wt% mix, and stir 11h at 30 DEG C, are then sonicated 7h,
It is finally centrifuged 6h under 2500rpm revolving speed, obtains solution, then place the product in CO2In supercritical high-pressure extraction device, with CO2
Supercritical drying 3h is carried out at 300 DEG C of temperature and air pressure 9MPa for medium, and the multiple dimensioned load medicine of carbon nanotube/montmorillonite can be obtained
Aeroge.
Embodiment 3
It takes 3g lauryl sodium sulfate (SDS), 15g dexamethasone to be added in 100g water, after sonic oscillation 16h, 6g is added
Carbon nanotube, ultrasonic disperse 19h obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to normal pressure,
It repeats vacuum step three times, obtains carbon nanotube and carry medicine wet gel；5h is dried into 3g montmorillonite at 180 DEG C, then uses solvent
It is configured to the montmorillonite dispersions that mass fraction is 13wt%；By montmorillonite dispersions with the speed machine of 150r/min at 12 DEG C
Tool stirs 6h, then with the ultrasonic treatment 8h of 300W power, obtains montmorillonite wet gel；By 25g carbon nanotube carry medicine wet gel,
30g montmorillonite wet gel, the gentamycin solution that 15g mass fraction is 0.05wt% mix, and 25h are stirred at 21 DEG C, then surpass
Sonication 8h is finally centrifuged 5h under 3500rpm revolving speed, obtains solution, then place the product in CO2Supercritical, high pressure extraction dress
In setting, with CO2Supercritical drying 3h is carried out at 220 DEG C of temperature and air pressure 20MPa for medium, and it is de- that carbon nanotube/illiteracy can be obtained
The multiple dimensioned load medicine aeroge of soil.
Embodiment 4
It takes 10g lauryl sodium sulfate (SDS), 0.05g dexamethasone to be added in 100g water, after sonic oscillation 5h, is added
The carbon nanotube of 1g, ultrasonic disperse for 24 hours, obtain dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to often
Pressure repeats vacuum step three times, obtains carbon nanotube and carries medicine wet gel；By 8g montmorillonite at 95 DEG C dry 19h, then with molten
Agent is configured to the montmorillonite dispersions that mass fraction is 0.6wt%；By montmorillonite dispersions at 5 DEG C with the speed of 330r/min
Mechanical stirring 8h, then with the ultrasonic treatment 6h of 50W power, obtain montmorillonite wet gel；By 30g carbon nanotube carry medicine wet gel,
29g montmorillonite wet gel, the gentamycin solution that 13g mass fraction is 9.3wt% mix, and 10h, then ultrasound are stirred at 35 DEG C
10h is handled, 4h is finally centrifuged under 1900rpm revolving speed, obtains solution, then place the product in CO2Supercritical, high pressure extraction dress
In setting, with CO2Supercritical drying 3h is carried out at 188 DEG C of temperature and air pressure 12MPa for medium, and it is de- that carbon nanotube/illiteracy can be obtained
The multiple dimensioned load medicine aeroge of soil.
Embodiment 5
It takes 6g lauryl sodium sulfate (SDS), 3.5g dexamethasone to be added in 100g water, after sonic oscillation 48h, 7g is added
Carbon nanotube, ultrasonic disperse 10h obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to normal pressure,
It repeats vacuum step three times, obtains carbon nanotube and carry medicine wet gel；15h is dried into 7g montmorillonite at 87 DEG C, then uses solvent
It is configured to the montmorillonite dispersions that mass fraction is 8wt%；By montmorillonite dispersions with the speed mechanical of 290r/min at 9 DEG C
10h is stirred, then with the ultrasonic treatment 15h of 122W power, obtains montmorillonite wet gel；1g carbon nanotube is carried into medicine wet gel, 16g
Montmorillonite wet gel, the gentamycin solution that 6g mass fraction is 0.9wt% mix, and stir 23h at 5 DEG C, are then sonicated
12h is finally centrifuged 2h under 3000rpm revolving speed, obtains solution, then place the product in CO2In supercritical high-pressure extraction device,
With CO2Supercritical drying 3h is carried out at 10 DEG C of temperature and air pressure 1MPa for medium, and it is multiple dimensioned that carbon nanotube/montmorillonite can be obtained
Carry medicine aeroge.
Embodiment 6
It takes 9g lauryl sodium sulfate (SDS), 9.7g dexamethasone to be added in 100g water, after sonic oscillation 31h, is added
The carbon nanotube of 10g, ultrasonic disperse 8h, obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to often
Pressure repeats vacuum step three times, obtains carbon nanotube and carries medicine wet gel；20h is dried into 5.6g montmorillonite at 133 DEG C, then
The montmorillonite dispersions that mass fraction is 0.1wt% are configured to solvent；By montmorillonite dispersions with 365r/min at 20 DEG C
Speed mechanical stir 9h, then with the ultrasonic treatment 13h of 92W power, obtain montmorillonite wet gel；It is wet that 9g carbon nanotube is carried into medicine
Gel, 6g montmorillonite wet gel, the gentamycin solution that 4.6g mass fraction is 15wt% mix, and stir 20h at 12.5 DEG C,
It is then sonicated 15h, 1h is finally centrifuged under 1000rpm revolving speed, obtains solution, then place the product in CO2Supercritical, high pressure
In extraction equipment, with CO2Supercritical drying 3h is carried out at 24 DEG C of temperature and air pressure 5MPa for medium, can be obtained carbon nanotube/
The multiple dimensioned load medicine aeroge of montmorillonite.
Embodiment 7
It takes 15g lauryl sodium sulfate (SDS), 20g dexamethasone to be added in 100g water, after sonic oscillation 5h, 15g is added
Carbon nanotube, ultrasonic disperse for 24 hours, obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to normal pressure,
It repeats vacuum step three times, obtains carbon nanotube and carry medicine wet gel；19h is dried into 15g montmorillonite at 95 DEG C, then uses solvent
It is configured to the montmorillonite dispersions that mass fraction is 25wt%；By montmorillonite dispersions at 5 DEG C with the speed machine of 330r/min
Tool stirs 8h, then with the ultrasonic treatment 6h of 50W power, obtains montmorillonite wet gel；35 carbon nanotubes are carried into medicine wet gel, 30g
Montmorillonite wet gel, the gentamycin solution that 20g mass fraction is 20wt% mix, and stir 10h at 35 DEG C, are then sonicated
10h is finally centrifuged 4h under 1900rpm revolving speed, obtains solution, then place the product in CO2In supercritical high-pressure extraction device,
With CO2Supercritical drying 2h is carried out at 268 DEG C of temperature and air pressure 15MPa for medium, and the more rulers of carbon nanotube/montmorillonite can be obtained
Degree carries medicine aeroge.
Embodiment 8
It takes 0.5g lauryl sodium sulfate (SDS), 0.01g dexamethasone to be added in 100g water, after sonic oscillation 16h, adds
Enter the carbon nanotube of 0.5g, ultrasonic disperse 19h obtains dispersion liquid；1h is kept after above-mentioned dispersion liquid is vacuumized, and is then restored to
Normal pressure repeats vacuum step three times, obtains carbon nanotube and carries medicine wet gel；5h is dried into 0.05g montmorillonite at 180 DEG C,
The montmorillonite dispersions that mass fraction is 0.05wt% are configured to solvent again；By montmorillonite dispersions with 150r/ at 12 DEG C
The speed mechanical of min stirs 6h, then with the ultrasonic treatment 8h of 300W power, obtains montmorillonite wet gel；By 0.5g carbon nanotube
It carries medicine wet gel, 0.5g montmorillonite wet gel, the gentamycin solution that 0.1g mass fraction is 0.05wt% to mix, at 21 DEG C
25h is stirred, 8h is then sonicated, 5h is finally centrifuged under 3500rpm revolving speed, obtains solution, then place the product in CO2It is super to face
In boundary's high-pressure extraction device, with CO2Supercritical drying 2h is carried out at 22 DEG C of temperature and air pressure 2MPa for medium, and carbon can be obtained and receive
The multiple dimensioned load medicine aeroge of mitron/montmorillonite.
Illustrative description has been done to the present invention above, it should explanation, the case where not departing from core of the invention
Under, any simple deformation, modification or other skilled in the art can not spend the equivalent replacement of creative work equal
Fall into protection scope of the present invention.
Claims (10)
1. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material, it is characterised in that: carbon nanotube-montmorillonite Composite gas
Gel rubber material average specific surface area is 600-608m2g-1, nanometer is existed simultaneously in carbon nanotube-montmorillonite Composite aerogel material
Scale and micro-meter scale hole, nanoscale hole average out to 10-12nm, 20-22 μm of average out to of micro-meter scale hole, under
State step progress:
Step 1, take 0.5-15 parts by weight lauryl sodium sulfate (SDS), 0.01-20 parts by weight dexamethasone that 100 weight are added
In part water, after sonic oscillation is uniform, the carbon nanotube of 0.5-15 parts by weight is added thereto, after ultrasonic disperse is uniform, vacuumizes
After keep vacuum, be then restored to normal pressure, repeat vacuum step three times, obtain the wet gel of step 1；
Step 2, by after 0.05-15 parts by weight montmorillonite drying, the montmorillonite dispersions of 0.05-25wt% are configured to solvent,
Montmorillonite dispersions mechanical stirring is uniform, after being then sonicated, obtain the wet gel of step 2；
Step 3, by the wet gel of 0.5-35 parts by weight step 1, the wet gel of 0.5-30 parts by weight step 2,0.1-20 parts by weight
The gentamycin solution that mass fraction is 0.05-20wt% mixes, and stirs evenly after being then sonicated centrifugation, obtains product, will
Product is placed in CO2In supercritical high-pressure extraction device, with CO2Surpassed at 10-300 DEG C of temperature and air pressure 1-20MPa for medium
Mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material can be obtained in critical drying at least 1h；
The dexamethasone being added in step 1 is dispersed in carbon nanotube hollow structure, and carbon nanotube hollow structure is mesoporous-micro-
Hole carbon nanotube-montmorillonite Composite aerogel material provides microcellular structure, dexamethasone is supported in carbon nanotube, carbon nanometer
Tridimensional network is formed between pipe, the montmorillonite being added in step 2 is successfully configured to network pore structure, above-mentioned three-dimensional netted
Structure and carbon nanotube are successfully configured to network pore structure and together form three-dimensional network pore structure, above-mentioned three-dimensional network hole
Gap structure provides meso-hole structure, while gentamicin being loaded for mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material
In meso-hole structure.
2. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material according to claim 1, it is characterised in that:
In step 1,1-10 parts by weight lauryl sodium sulfate (SDS), 0.05-15 parts by weight dexamethasone are added to the water, ultrasound vibration
After swinging 2-48h, the carbon nanotube of 1-10 parts by weight is added thereto, after ultrasonic disperse 1-24h, keeps 1h after vacuumizing.
3. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material according to claim 1, it is characterised in that:
In step 2,5-20h is dried into the montmorillonite of 0.1-10 parts by weight at 60-180 DEG C, the illiteracy of 0.1-20wt% is configured to solvent
Montmorillonite dispersions are stirred 4-10h at 5-35 DEG C with the speed mechanical of 150-400r/min, then use 50- by de- soil dispersion liquid
The ultrasonic treatment 6-15h of 300W power.
4. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material according to claim 1, it is characterised in that:
In step 3,1-30 parts by weight of carbon nanotubes is carried into medicine wet gel, 1-30 parts by weight montmorillonite wet gel, 0.5-15 parts by weight matter
It measures the gentamycin solution that score is 0.05-15wt% to mix, 10-25h is stirred at 5-35 DEG C, is ultrasonically treated 6-15h, finally
1-8h is centrifuged under 1000-3500rpm revolving speed.
5. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material according to claim 1, it is characterised in that:
In step 3, the supercritical drying time is 2-4h, preferably 3h.
6. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material preparation method, it is characterised in that: according to following steps
It is rapid to carry out:
Step 1, take 0.5-15 parts by weight lauryl sodium sulfate (SDS), 0.01-20 parts by weight dexamethasone that 100 weight are added
In part water, after sonic oscillation is uniform, the carbon nanotube of 0.5-15 parts by weight is added thereto, after ultrasonic disperse is uniform, vacuumizes
After keep vacuum, be then restored to normal pressure, repeat vacuum step three times, obtain the wet gel of step 1；
Step 2, by after 0.05-15 parts by weight montmorillonite drying, the montmorillonite dispersions of 0.05-25wt% are configured to solvent,
Montmorillonite dispersions mechanical stirring is uniform, after being then sonicated, obtain the wet gel of step 2；
Step 3, by the wet gel of 0.5-35 parts by weight step 1, the wet gel of 0.5-30 parts by weight step 2,0.1-20 parts by weight
The gentamycin solution that mass fraction is 0.05-20wt% mixes, and stirs evenly after being then sonicated centrifugation, obtains product, will
Product is placed in CO2In supercritical high-pressure extraction device, with CO2Surpassed at 10-300 DEG C of temperature and air pressure 1-20MPa for medium
Mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material can be obtained in critical drying at least 1h；
The dexamethasone being added in step 1 is dispersed in carbon nanotube hollow structure, and carbon nanotube hollow structure is mesoporous-micro-
Hole carbon nanotube-montmorillonite Composite aerogel material provides microcellular structure, dexamethasone is supported in carbon nanotube, carbon nanometer
Tridimensional network is formed between pipe, the montmorillonite being added in step 2 is successfully configured to network pore structure, above-mentioned three-dimensional netted
Structure and carbon nanotube are successfully configured to network pore structure and together form three-dimensional network pore structure, above-mentioned three-dimensional network hole
Gap structure provides meso-hole structure, while gentamicin being loaded for mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material
In meso-hole structure.
7. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material preparation method according to claim 1,
It is characterized in that: in step 1,1-10 parts by weight lauryl sodium sulfate (SDS), 0.05-15 parts by weight dexamethasone being added
In water, after sonic oscillation 2-48h, the carbon nanotube of 1-10 parts by weight is added thereto, after ultrasonic disperse 1-24h, after vacuumizing
Keep 1h.
8. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material preparation method according to claim 1,
It is characterized in that: in step 2,5-20h is dried into the montmorillonite of 0.1-10 parts by weight at 60-180 DEG C, is configured to 0.1- with solvent
Montmorillonite dispersions are stirred 4- at 5-35 DEG C with the speed mechanical of 150-400r/min by the montmorillonite dispersions of 20wt%
10h, then the ultrasonic treatment 6-15h with 50-300W power.
9. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material preparation method according to claim 1,
It is characterized in that: in step 3,1-30 parts by weight of carbon nanotubes being carried into medicine wet gel, 1-30 parts by weight montmorillonite wet gel, 0.5-
The gentamycin solution that 15 parts by weight mass fractions are 0.05-15wt% mixes, and 10-25h is stirred at 5-35 DEG C, is ultrasonically treated
6-15h is finally centrifuged 1-8h under 1000-3500rpm revolving speed.
10. mesoporous-micropore carbon nanotube-montmorillonite Composite aerogel material preparation method according to claim 1,
Be characterized in that: in step 3, the supercritical drying time is 2-4h, preferably 3h.
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