CN109985085A - A kind of compound preparation and preparation method thereof of pet heart disease - Google Patents
A kind of compound preparation and preparation method thereof of pet heart disease Download PDFInfo
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
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- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The purpose of the present invention is to provide a kind of preparations and preparation method thereof of pet heart disease, inventive formulation composition is scientific and reasonable, simple process, it is easy to use, drug residue free and toxic side effect, clinical studies show add this preparation in the pet diet having a heart disease for a long time,, fluid retention stagnating in the interior, the phlegm turbid heart failure significant effect do not changed stagnant for the treatment blood vessels stasis of blood, more particularly to which the incidence probability of pet chronic heart failure is effectively reduced.
Description
Technical field
The invention belongs to feed additive fields, and in particular to a kind of pet preparation and its preparation for alleviating chronic heart failure
Method.
Background technique
With the development of society, the improvement of people's living standards, more and more families start to keep a pet, as animal is cured
The improvement of horizontal progress and living environment is treated, the service life of dog is extended.On the other hand, with advancing age, the chronic heart
The morbidity of popular name for also starts to increase.Heart, which is responsible for, send blood to blood-pumping function to whole body everywhere, if blood-pumping function cannot
It runs well, blood cannot be transported to lung and whole body everywhere, the blood returned everywhere from lung and whole body can not be recycled, from
And cause blood flow reduction and extravasated blood etc..10~15% canine is suffering from different degrees of heart disease.Moreover, it has become
The 2nd big canine killer after cancer.Pet mainly has following symptom after suffering from a heart complaint: cough, shortness of breath, fatiguability, spirit
Dimly, expiratory dyspnea, abdominal distension, weight loss etc..The course of disease can be divided into four periods: the I phase: symptom is not fairly obvious, the II phase: movement
Shi Huibiao such as newly has difficulty in breathing, coughs at the symptoms；The III phase: it will appear the symptoms such as cough, expiratory dyspnea usually movable；IV
Phase: even if can also show the symptoms such as cough, expiratory dyspnea in peace and quiet.Therefore, scientific knowledge heart disease and prophylactic treatment ten
Divide important.
In common feedstuff and additive, Radix Codonopsis is sweet in flavor, mild-natured.There is tonifying middle-Jiao and Qi, quench the thirst, strengthening spleen and tonifying lung, supports
Blood promotes the production of body fluid.Ginseng is sweet in flavor, slight bitter, mild-natured, returns spleen, lung, the heart channel of Hang-Shaoyin.Replenish vital energy, restore pulse, and strengthen and remove vital energy reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves.
Radix Astragali is sweet in flavor, tepor, return lung, spleen, liver and kidney channel, there is enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, drop
Pressure and wide antibacterial action.Rhizome of chuanxiong acrid flavour, it is warm-natured, return liver, gallbladder, the heart channel of Hang-Shaoyin.With blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.
Radix Glycyrrhizae is sweet in flavor, mild-natured, return heart, lung, spleen, stomach meridian.It is clearing heat and detoxicating with invigorating the spleen and benefiting qi, the effect of expelling phlegm and arresting coughing, relieving spasm to stop pain,
It can coordinating the drug actions of a prescription.
Co-Q10 can not only provide power to heart, also have the anti-oxidant of brilliance, remove free radical function, can prevent
Vascular wall lipid peroxidation, prevention of arterial atherosis, and it is without any side effects.Taurine can inhibit in the circulatory system
Platelet aggregation reduces blood lipid, keeps animal body normal arterial pressure and prevents artery sclerosis；There is protective effect to cardiac muscle cell,
It can anti-arrhythmia；There is special efficacy to blood cholesterol level is reduced, heart failure can be treated.What spirulina powder contained
Gamma-Linolenic acid can reduce the cholesterol concentration in animal body blood, chlorophyll, serine, sylvite and the vitamin contained
B6 can help animal body to synthesize choline, advantageously reduce blood lipid, reduce blood pressure, reduce viscosity of blood, keep blood vessel elasticity,
Artery sclerosis is prevented, heart disease and headstroke are prevented.
The present invention selects said components for pet heart disease, cooperates various auxiliary materials that the product of various dosage forms is made, effectively
The heart disease of prophylactic treatment pet.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation and preparation method thereof of pet heart disease, inventive formulation compositions
Scientific and reasonable, simple process is easy to use, drug residue free and toxic side effect, clinical studies show, what is had a heart disease
Pet diet in add this preparation for a long time, for treatment, the blood vessels stasis of blood is stagnant, fluid retention stagnating in the interior, the turbid heart failure significant effect that do not change of phlegm,
More particularly to which the incidence probability of pet chronic heart failure is effectively reduced.It is another object of the present invention to provide a kind of pets diligently
The preparation method of the compound preparation of popular name for.
The present invention is achieved by the following technical solutions:
The pet heart disease compound preparation includes following component: 3~10 parts of Radix Codonopsis, 2~3 parts of ginseng, Rhizoma Chuanxiong 3~5
Part, 3~10 parts of Radix Astragali, 2~4 parts of Radix Glycyrrhizae, Co-Q10 0.015~0.3,0.03~1.5 part of taurine, spirulina powder 0~5
Part.
The dosage form of the compound preparation is granule, powder, capsule, tablet, pill or oral solution.
The compound preparation is applied to adjuvant treatment pet heart disease, is particularly suitable for chronic heart failure.
The preparation of the adjuvant treatment pet heart disease, we are reinforced vital energy with giving birth to Radix Codonopsis, ginseng as monarch, shengjin nourishing
With Zhi Qiben；Minister is with rhizome of chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping；Help Radix Astragali tonifying Qi Yiyang, inducing diuresis for removing edema；Radix Glycyrrhizae coordinating the drug actions of a prescription, is played altogether
The function of qi and activate blood circulation, warming yang for diuresis.Cooperate Co-Q10, taurine, spirulina powder simultaneously, promotes pet heart function.
The remarkable advantage of the compound preparation is: the preparation is turbid for assisting in the treatment of the stagnant blood vessels stasis of blood, fluid retention stagnating in the interior, phlegm
Type chronic heart failure significant effect is not changed.
The step of preparation method of the compound preparation, is as follows:
(1) alcohol extracting: by Radix Codonopsis, ginseng by formula ratio with 1~5 times (volume ratio) ethyl alcohol soak extraction 1~3 hour, extraction
Liquid filtering and concentrating, obtains alcohol extracting concentrate；
(2) water mentions: Radix Astragali, Rhizoma Chuanxiong, three taste medicinal material of Radix Glycyrrhizae is small with 4~15 times of (volume ratio) water extractions 1~3 by formula ratio
When, extracting solution filtering and concentrating obtains water extracting liquid；
(3) water extracting liquid merges with alcohol extracting concentrate, and preparing solid pharmaceutical preparation need to continue in outer circulation single effect evaporator
It is concentrated into clear cream taking-up；
(4) Co-Q10, taurine, spirulina powder are merged into concentrate or clear cream with above-mentioned after mixing by formula ratio
Cooperation to get.
Pharmaceutically acceptable conventional agent is made using conventional preparation method preparation in the dosage form of compound preparation of the present invention
Type, such as granule, powder, capsule, tablet, pill or oral solution.To can be realized above-mentioned dosage form, these agent need to prepared
Pharmaceutically acceptable auxiliary material is added when type, such as: filler, disintegrating agent, lubricant, suspending agent, adhesive, sweetener, flavoring
Agent, preservative, matrix etc..
Currently, the country has not seen that pet is without reference to comparable with cardiopathic related patents are treated.
The compound preparation is mainly used for:
The normal person's appearance of heart function is tired, exercise tolerance obviously lowers, nocturnal paroxysmal dyspnea, checks the visible left heart
Room increases, there are moist rales, dry rale and wheezing sound in diastole early stage or mid-term cantering rhythm, two base of lung portions.
The invention has the advantages and beneficial effects that:
(1) inventive formulation form scientific and reasonable, simple process, it is easy to use, natural no stimulation, drug residue free and
Toxic side effect.
(2) present invention has positive effect to adjuvant treatment pet heart disease, and it is long to be especially suitable for the pet with chronic heart failure
Phase takes, and can improve prognosis, improves pet quality of life, reduces disease incidence.
Specific embodiment
Below with reference to the tool of the example of the preparation of medicinal granule of the present invention, powder, capsule, tablet, pill, oral solution
Body embodiment elaborates, but the present invention is not limited thereto, and that is done all within the spirits and principles of the present invention appoints
What is modified, and equivalent replacement and improvement etc. should be included within the scope of the present invention.
Experimental method described in following embodiments is unless otherwise specified conventional method；The reagent and material, such as
Without specified otherwise, commercially obtain.
Embodiment 1
Weigh 6 parts of Radix Codonopsis, 3 parts of ginseng, 6 parts of Radix Astragali, 4 parts of Rhizoma Chuanxiong, 4 parts of Radix Glycyrrhizae, 0.05 part of Co-Q10, taurine 0.5
Part, 3 parts of spirulina powder.
Preparation method:
(1) alcohol extracting: by Radix Codonopsis, ginseng with 1~5 times (volume ratio) ethyl alcohol soak extraction 1~3 hour, extracting solution filtering it is dense
Contracting；
(2) water mentions: Radix Astragali, Rhizoma Chuanxiong, three taste medicinal material of Radix Glycyrrhizae, 4~15 times of (volume ratio) water being extracted 1~3 hour, are extracted
Liquid filtering and concentrating；
(3) water extracting liquid merges with alcohol extracting concentrate, continues in outer circulation single effect evaporator and is concentrated into clear cream taking-up；
(4) it pelletizes: Co-Q10, taurine, spirulina powder is uniformly mixed, auxiliary material is added and is mixed with clear cream, granulation is dried
Dry, whole grain, packaging.
Embodiment 2
Weigh 10 parts of Radix Codonopsis, 3 parts of ginseng, 10 parts of Radix Astragali, 3 parts of Rhizoma Chuanxiong, 3 parts of Radix Glycyrrhizae, 0.015 part of Co-Q10, taurine
0.03 part, 5 parts of spirulina powder.
It is uniformly mixed after Chinese herbal medicine is crushed according to a conventional method with Co-Q10, taurine and spirulina powder, pulvis is made.
Embodiment 3
Weigh 5 parts of Radix Codonopsis, 3 parts of Radix Astragali, 2 parts of Radix Angelicae Sinensis, 2 parts of purple perilla, 3 parts of Poria cocos, 1 part of ginger, 2 parts of jujube, Co-Q10
0.3 part, 1.5 parts of taurine, 4 parts of spirulina powder.
Capsule is made according to a conventional method.
Embodiment 4
Weigh 3 parts of Radix Codonopsis, 2 parts of ginseng, 7 parts of Radix Astragali, 4 parts of Rhizoma Chuanxiong, 4 parts of Radix Glycyrrhizae, 0.2 part of Co-Q10,1 part of taurine,
2 parts of spirulina powder.
Cooperate remaining supplementary material that tablet is made with Chinese medical concrete according to a conventional method.
Embodiment 5
Weigh 8 parts of Radix Codonopsis, 2.5 parts of ginseng, 5 parts of Radix Astragali, 4 parts of Rhizoma Chuanxiong, 4 parts of Radix Glycyrrhizae, 0.8 part of taurine, spirulina powder 3
Part.
Pill is made according to a conventional method.
Embodiment 6
Weigh 7 parts of Radix Codonopsis, 7 parts of Radix Astragali, 4 parts of Radix Angelicae Sinensis, 3 parts of purple perilla, 4 parts of Poria cocos, 2 parts of ginger, 5 parts of jujube, Co-Q10
0.05 part, 0.5 part of taurine, 0 part of spirulina powder.
Oral solution is made according to a conventional method.
Embodiment 7: clinical test
The dog having a heart disease is divided into two groups by November, 2016, Tianjin pet clinic, respectively to 20 illness dogs
Test is compared, 1 group is, using 1 group of the embodiment of the present invention, 10 grams every time, 2-3 times daily, spice feeds；2 groups are blank pair
According to group, after continuous use 15 days, comparative test observes the breathing situation under the motion state of dog, checks left ventricle situation, follow-up
Incidence in half a year.Paired observation is as follows:
Comparative test result
From the above, it can be seen that: compound preparation of the present invention can be effectively improved the physical condition for the pet having a heart disease, drop
Low cardiopathic incidence probability.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent and
Modification, all should belong to covering scope of the invention.
Claims (4)
1. a kind of pet heart disease compound preparation, including following parts by weight component: 3~10 parts of Radix Codonopsis, 2~3 parts of ginseng, river
3~5 parts of rhizome of chuanxiong, 3~10 parts of Radix Astragali, 2~4 parts of Radix Glycyrrhizae, Co-Q10 0.015~0.3,0.03~1.5 part of taurine, spirulina powder
0~5 part.
2. a kind of pet heart disease compound preparation as described in claim 1, which is characterized in that further include filler, disintegration
One of agent, lubricant, suspending agent, adhesive, sweetener, corrigent, preservative, matrix or a variety of mixing.
3. the step of pet heart disease compound preparation as described in claim 1, preparation method, is as follows:
(1) alcohol extracting: by Radix Codonopsis, ginseng by formula ratio with 1~5 times (volume ratio) ethyl alcohol soak extraction 1~3 hour, extracting solution mistake
Filter concentration, obtains alcohol extracting concentrate；
(2) water mentions: Radix Astragali, Rhizoma Chuanxiong, three taste medicinal material of Radix Glycyrrhizae are extracted 1~3 hour by 4~15 times of (volume ratio) water of formula ratio,
Extracting solution filtering and concentrating, obtains water extracting liquid；
(3) water extracting liquid merges with alcohol extracting concentrate, prepares solid pharmaceutical preparation and need to continue in outer circulation single effect evaporator and is concentrated
It is taken out to clear cream；
(4) Co-Q10, taurine, spirulina powder are merged into concentrate or clear cream cooperation with above-mentioned after mixing by formula ratio,
To obtain the final product.
4. pet heart disease compound preparation a method according to any one of claims 1-3, which is characterized in that the compound preparation can be made
At granule, powder, capsule, tablet, pill or oral solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711483906.3A CN109985085A (en) | 2017-12-29 | 2017-12-29 | A kind of compound preparation and preparation method thereof of pet heart disease |
Applications Claiming Priority (1)
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| CN201711483906.3A CN109985085A (en) | 2017-12-29 | 2017-12-29 | A kind of compound preparation and preparation method thereof of pet heart disease |
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| CN109985085A true CN109985085A (en) | 2019-07-09 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526173A (en) * | 2011-12-31 | 2012-07-04 | 中国人民解放军第三七一医院 | Chinese medicinal formulation for treating coronary heart disease and cerebral thrombosis |
| CN104137952A (en) * | 2014-08-08 | 2014-11-12 | 上海比瑞吉宠物用品有限公司 | Nutrient food for maintaining heart health of dogs and cats and preparation method of nutrient food |
-
2017
- 2017-12-29 CN CN201711483906.3A patent/CN109985085A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526173A (en) * | 2011-12-31 | 2012-07-04 | 中国人民解放军第三七一医院 | Chinese medicinal formulation for treating coronary heart disease and cerebral thrombosis |
| CN104137952A (en) * | 2014-08-08 | 2014-11-12 | 上海比瑞吉宠物用品有限公司 | Nutrient food for maintaining heart health of dogs and cats and preparation method of nutrient food |
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