CN109963597A - 聚乙二醇化血管内皮抑制素类似物及其应用 - Google Patents
聚乙二醇化血管内皮抑制素类似物及其应用 Download PDFInfo
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- CN109963597A CN109963597A CN201780069252.1A CN201780069252A CN109963597A CN 109963597 A CN109963597 A CN 109963597A CN 201780069252 A CN201780069252 A CN 201780069252A CN 109963597 A CN109963597 A CN 109963597A
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- polyethylene glycol
- vascellum esoderma
- esoderma inhibin
- analog
- lysine residue
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Abstract
本发明提了供聚乙二醇修饰的血管内皮抑制素类似物及其应用,所述血管内皮抑制素类似物在远离nucleolin结合区域的赖氨酸与聚乙二醇偶联或者在远离nucleolin结合区域的赖氨酸以及N端的氨基与聚乙二醇偶联。
Description
PCT国内申请,说明书已公开。
Claims (23)
- PCT国内申请,权利要求书已公开。
Priority Applications (1)
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CN202210948599.6A CN115721730A (zh) | 2016-11-10 | 2017-11-10 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
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CN201610997233 | 2016-11-10 | ||
CN2016109972332 | 2016-11-10 | ||
PCT/CN2017/110532 WO2018086603A1 (zh) | 2016-11-10 | 2017-11-10 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
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CN201780069252.1A Active CN109963597B (zh) | 2016-11-10 | 2017-11-10 | 聚乙二醇化血管内皮抑制素类似物及其应用 |
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US (1) | US11098104B2 (zh) |
EP (1) | EP3539570B1 (zh) |
JP (1) | JP7140454B2 (zh) |
CN (2) | CN115721730A (zh) |
AU (1) | AU2017357327B2 (zh) |
CA (1) | CA3043380A1 (zh) |
WO (1) | WO2018086603A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111166869A (zh) * | 2019-12-30 | 2020-05-19 | 江苏大学 | 一种量子点与重组人内皮抑制素偶联物及其制备工艺 |
CN114438047A (zh) * | 2020-11-05 | 2022-05-06 | 重庆派金生物科技有限公司 | 制备聚乙二醇修饰的尿酸氧化酶的方法 |
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KR20210143127A (ko) * | 2020-05-19 | 2021-11-26 | 애니젠 주식회사 | 신규 뉴클레오린-결합 펩타이드 및 이의 용도 |
CN115703828A (zh) * | 2021-08-09 | 2023-02-17 | 刘鹏 | 一种抗血管生成药物 |
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2017
- 2017-11-10 EP EP17870533.1A patent/EP3539570B1/en active Active
- 2017-11-10 CN CN202210948599.6A patent/CN115721730A/zh active Pending
- 2017-11-10 CN CN201780069252.1A patent/CN109963597B/zh active Active
- 2017-11-10 AU AU2017357327A patent/AU2017357327B2/en active Active
- 2017-11-10 JP JP2019524188A patent/JP7140454B2/ja active Active
- 2017-11-10 US US16/349,191 patent/US11098104B2/en active Active
- 2017-11-10 WO PCT/CN2017/110532 patent/WO2018086603A1/zh unknown
- 2017-11-10 CA CA3043380A patent/CA3043380A1/en active Pending
Patent Citations (4)
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WO2007082483A1 (fr) * | 2006-01-20 | 2007-07-26 | Tsinghua University | Médicament pour le traitement de tumeurs et son utilisation |
CN101596320A (zh) * | 2006-01-20 | 2009-12-09 | 清华大学 | 一种***的药物及其应用 |
CN101219206A (zh) * | 2008-02-01 | 2008-07-16 | 山东先声麦得津生物制药有限公司 | 重组人血管内皮抑制素在制药中的应用 |
JP2013532126A (ja) * | 2010-05-11 | 2013-08-15 | フレッド ハッチンソン キャンサー リサーチ センター | クロロトキシン変異体、コンジュゲート、およびそれらを使用する方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111166869A (zh) * | 2019-12-30 | 2020-05-19 | 江苏大学 | 一种量子点与重组人内皮抑制素偶联物及其制备工艺 |
CN114438047A (zh) * | 2020-11-05 | 2022-05-06 | 重庆派金生物科技有限公司 | 制备聚乙二醇修饰的尿酸氧化酶的方法 |
Also Published As
Publication number | Publication date |
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AU2017357327A1 (en) | 2019-06-13 |
EP3539570A4 (en) | 2020-06-17 |
EP3539570A1 (en) | 2019-09-18 |
JP7140454B2 (ja) | 2022-09-21 |
JP2019535700A (ja) | 2019-12-12 |
CN115721730A (zh) | 2023-03-03 |
AU2017357327B2 (en) | 2023-04-06 |
US20200270333A1 (en) | 2020-08-27 |
WO2018086603A1 (zh) | 2018-05-17 |
CN109963597B (zh) | 2022-08-26 |
EP3539570B1 (en) | 2022-04-13 |
US11098104B2 (en) | 2021-08-24 |
CA3043380A1 (en) | 2018-05-17 |
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