CN109925310A - Blood-pressure drug containing therapeutically effective amount ginkgolides - Google Patents
Blood-pressure drug containing therapeutically effective amount ginkgolides Download PDFInfo
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- CN109925310A CN109925310A CN201910318522.9A CN201910318522A CN109925310A CN 109925310 A CN109925310 A CN 109925310A CN 201910318522 A CN201910318522 A CN 201910318522A CN 109925310 A CN109925310 A CN 109925310A
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Abstract
The present invention provides the blood-pressure drug containing therapeutically effective amount ginkgolides, the ginkgolides is one of ginkalide A, ginkolide B, ginkalide C, bilobalide J, ginkgolides M, Bilobalide or a variety of.The present invention is studies have shown that ginkgolide monomer compound and combinations thereof all has good hypotensive activity, and especially under the proportion that the present invention limits, the more notable raising of blood pressure lowering effect provides new selection for clinical application.
Description
The present invention is patent application day are as follows: 2014/12/10；Application No. is: 201410756745.0；Invention and created name
For the divisional application of " purposes of the ginkgolides in the drug for preparing blood pressure lowering ".
Technical field
The present invention relates to the blood-pressure drugs containing therapeutically effective amount ginkgolides.
Background technique
Hypertension is the most common chronic disease and the most important risk factor of cardiovascular and cerebrovascular diseases, cerebral apoplexy, cardiac muscle stalk
Extremely, heart failure and chronic kidney disease are its major complications.It is both domestic and external it was verified that hypertension is can to prevent and control
Disease, reduce the blood pressure level of hypertensive patient, can obviously reduce cerebral apoplexy and the events of heart attack, significantly improve the life of patient
Quality is deposited, Disease Spectrum is effectively reduced.The blood pressure level of the harmfulness of hypertension and patient mutually outside the Pass, are additionally depended on and are existed simultaneously
Other cardiovascular risk factors, target organ damage and the case where combined other diseases.Therefore in the definition of hypertension
In classification, the diagnostic criteria of hypertension is scheduled on systolic pressure >=140mmHg and (or) diastolic pressure >=90mmHg, according to blood pressure water
It is bisected into except normal, High-normal blood pressure and 1,2,3 grade of hypertension, while also according to risk factor, target organ damage and same
When the other diseases that merge carry out risk stratification.Prevalence of Hypertension increases with the age and is increased；Women illness before climacteric
Rate is slightly below male, but increases rapidly after climacteric, even higher than male；High latitude cold district illness rate is higher than low latitudes
Warm area, high altitude localities are higher than low altitude area；Related with eating habit, salt and saturated fat intake are higher, average blood
Voltage levels and illness rate are also higher.There are two compare outstanding feature to population of China hypertension prevalence: from south to the north, high blood
Pressing illness rate is in increasing trend；There are also differences for Prevalence of Hypertension between different nationalities, live in the north or highlands
National illness rate it is higher, and the national illness rate for living in south or non-highlands is then lower, this species diversity may be with ground
It is related to manage environment, life style etc., not yet has apparent genetic background difference between discovery various nationalities.Treat the main of hypertension
Purpose is to reduce cardiovascular morbidity and dead total danger to the maximum extent, therefore it is required that doctor is while treating hypertension,
Intervene all invertibity cardiovascular risk factors of patient, target organ damage and merges existing clinical disease.For general high
It is 140/90mmHg hereinafter, for high risk patients such as complication with diabetes or nephrosis that blood pressure patient, which is depressured target, and blood pressure should be in patient
Take the circumstances into consideration to be down to more low-level in the case where being resistant to.
Ginkgolides (English name: ginkgolide) compound belongs to terpenoid, by sesquiterpene lactone and diterpene
Ester composition is a kind of important active constituent in ginkgo leaf.The ginkgolides reported at present have antiallergy, anti-inflammatory, Hemorrhagic shock,
To the protections of ischemic injuries, to the protective effect of organ transplant rejection's reaction (pipe filial piety is brought up, ginkgolides pharmacological research into
Exhibition, the 3rd phase of volume 22 nineteen ninety-five), Xu Jiangping, etc., the influence of ginkgolide on cerebral blood flow in dogs, Journal of Chinese Integrative Medicine,
2005-01-15, it was recently reported that ginkgolides can reduce anesthetized dog cerebral vascular resistance, increase cerebral blood flow (CBF), do not influence heart rate and blood
Pressure.
Summary of the invention
One of the objects of the present invention is to provide the blood-pressure drugs containing therapeutically effective amount ginkgolides；Mesh of the invention
Two be to provide the blood-pressure drug preparation containing therapeutically effective amount ginkgolides.
Blood-pressure drug containing therapeutically effective amount ginkgolides, the ginkgolides be ginkalide A, ginkolide B,
One of ginkalide C, bilobalide J, ginkgolides M, Bilobalide are a variety of.
Preferably, the ginkgolides is ginko diterpenoid lactone and Bilobalide.
Preferably, the ginko diterpenoid lactone is selected from ginkalide A, ginkolide B, ginkalide C, ginkgolides
One or both of J or ginkgolides M or more.
Preferably, the ginko diterpenoid lactone: Bilobalide=(5~60): (5~65) w/w.
Preferably, the ginko diterpenoid lactone: Bilobalide=(5: 5) w/w or (5: 65) w/w or (60: 5) w/w
Or (5: 10) w/w or (15: 5) w/w.
Preferably, the ginko diterpenoid lactone is selected from one of following combination:
(1) ginkalide A: ginkolide B=(10~45): (5~40) w/w；
(2) ginkalide A: ginkalide C=(10~45): (3~35) w/w；
(3) ginkolide B: ginkalide C=(5~40): (3~35) w/w；
(4) ginkalide A: ginkolide B: ginkalide C=(10~45): (5~40): (3~35) w/w/w.
Wherein, the dosage quality proportioning of three kinds of Ginkgolide A. B. C combinations are as follows: ginkalide A: ginkolide B:
Ginkalide C=20: 30: 10 or 10: 5: 3 or 45: 5: 35 or 10: 40: 35 or 30: 10: 10.
The present invention also provides a kind of preparation of blood-pressure drug containing effective quantity ginkgolides, the preparation is oral
Preparation, ejection preparation or transdermal absorption formulation.
The present invention provides the compositions containing following weight proportion component to prepare the purposes in blood-pressure drug: ginkgo
Diterpenes diterpenoids lactones: Bilobalide=(5~60): (5~65) w/w.
It is further preferred that the weight proportion of ginko diterpenoid lactone, Bilobalide are as follows: ginko diterpenoid lactone: gingko
Lactone=5:5W/W or 5:65W/W or 60:5W/W or 5:10W/W or 15:5W/W.
Wherein, the ginko diterpenoid lactone is selected from the combination of one or more of Ginkgolide A. B. C, J, M.
It is further preferred that the ginko diterpenoid lactone is selected from one or more of Ginkgolide A. B. C
Combination.
Wherein, the two or more combination of the Ginkgolide A. B. C is selected from one of following:
(1) ginkalide A: ginkolide B=(10~45): (5~40)；
(2) ginkalide A: ginkalide C=(10~45): (3~35)；
(3) ginkolide B: ginkalide C=(5~40): (3~35)；
(4) ginkalide A: ginkolide B: ginkalide C=(10~45): (5~40): (3~35).
It is further preferred that described three kinds of the Ginkgolide A. B. C consumption proportions combined are as follows: ginkalide A: in ginkgo
Ester B: ginkalide C=20:30:10 or 10:5:3 or 45:5:35 or 10:40:35 or 30:10:10.
Wherein, the drug is the drug for treating hypertension.
Wherein, the pharmaceutical preparation is oral preparation, ejection preparation or transdermal absorption formulation.
The present invention also provides ginkgolides to prepare the purposes in blood-pressure drug.
The present invention is studies have shown that ginkgo lactone composition passes through the weight for controlling wherein ginko diterpenoid lactone and Bilobalide
Amount proportion has good hypotensive activity, and especially under the proportion that the present invention limits, blood pressure lowering effect is more notable to be mentioned
Height provides new selection for clinical application.
Specific embodiment
Ginkgolide monomer compound of the present invention can be obtained by buying commercial product, or by existing
Method isolates and purifies preparation.Through examining, all monomeric compounds are consistent with corresponding reference substance structure, and it is pure through HPLC to detect its
Degree is 98% or more.
The two or more composition of ginko diterpenoid lactone of the present invention can be combined by corresponding monomeric compound
It forms.
Composition of the present invention containing ginkgolectone AB C and Bilobalide, can directly buy commercially available ginkgo
Interior ester injection, or be made by the method for ZL200610103626.0 or ZL200610103625.6, can also be by will be single
Body compound combination forms.
Beneficial effects of the present invention are illustrated below by way of test example.
The effect of test example 1, bilobalide injection to renal hypertension Rabbits Models blood pressure
1. experiment equipment
1.1 reagents and drug: 1% yellow Jackets (Shanghai Sinopharm Chemical Reagent Co., Ltd.), adrenaline note
Penetrate liquid, bilobalide injection (Chengdu Baiyu Pharmaceutical Technology Co., Ltd.'s production, according to granted patent
The method of embodiment two in ZL200610103625.6 is made, wherein ginkalide A: ginkolide B: ginkalide C=
The weight ratio of 20:30:10, Ginkgolide A. B. C total amount and Bilobalide is 1:1, ginkgolides content: 4.91mg/ml),
Ginkalide A (Chengdu Baiyu Pharmaceutical Technology Co., Ltd. provides, content: 5.0mg/ml), ginkolide B (the abundant offer in Chengdu hundred,
Content: 5.0mg/ml), ginkalide C (the abundant offer in Chengdu hundred, content: 5.0mg/ml), (the abundant offer in Chengdu hundred, contains Bilobalide
Amount: 5.0mg/ml), ginkgo lactone composition 1 (the abundant offer in Chengdu hundred, ginkalide A: ginkolide B: ginkalide C=10:
The weight ratio of 5:3, Ginkgolide A. B. C total amount and Bilobalide is 60:5, ginkgolides content: 5.0mg/ml), in ginkgo
(the abundant offer in Chengdu hundred, ginkalide A: ginkolide B: ginkalide C=45:5:35, Ginkgolide A. B. C are total for ester composition 2
The weight ratio of amount and Bilobalide is 5:65, ginkgolides content: 5.0mg/ml), (Chengdu hundred is abundant for ginkgo lactone composition 3
It provides, ginkalide A: ginkolide B: ginkalide C=10:40:35, the weight of Ginkgolide A. B. C total amount and Bilobalide
Amount ratio is 5:10, ginkgolides content: 5.0mg/ml), ginkgo lactone composition 4 (the abundant offer in Chengdu hundred, ginkalide A: silver
Apricot lactone B: the weight ratio of ginkalide C=30:10:10, Ginkgolide A. B. C total amount and Bilobalide is 15:5, ginkgo
Lactone content: 5.0mg/ml), physiological saline, heparin-saline solution, enalaprilat injection (Changzhou pharmacy).
1.2 laboratory apparatus: BL-420E System of organism signal (Chengdu TME Technology Co., Ltd.), pressure are changed
It can device.
1.3 experimental animals: healthy adult rabbit (being provided by Sichuan Province's Experimental Animal Center) 84,2~2.5kg of weight,
Male and female are unlimited.
2. experimental method
2.1 animal packets and modeling: 84 rabbit are randomly divided into 14 groups, i.e. high, medium and low dose of bilobalide injection
Amount, model comparison, positive control, normal control, ginkalide A, ginkolide B, ginkalide C, Bilobalide, composition 1,
Totally 14 groups of composition 2, composition 3, composition 4, every group 6.Rabbit in addition to Normal group carries out double renal artery stenosis
Art is improved, ligatures left and right main renal artery simultaneously with silver brain clip, causes the arteria renalis is not entirely narrow to cause renal hypertension model.It feeds
After 4 weeks, tested.
2.2 anesthesia: rabbit weighing, yellow Jackets (30mg/kg) Anaesthetic Rabbits of auricular vein injection 1%.
2.3 operations: rabbit after anesthesia is fixed on rabbit autopsy table, in the skin incision of 5~7cm of neck midsection,
One section of arteria carotis communis is isolated, distal end is pricked with knot, and it is spare that proximal part with line makes a call to an empty knot, proximal part is clamped with artery clamp,
An osculum is cut on arteria carotis communis, fills with the arterial insertion arteria carotis communis of heparin-saline, ligation is fixed immediately, warp
Pressure transducer gives blood pressure input System of organism signal record and processing to the preceding negative of 160mmHg or so
Lotus.
2.4 administrations: decontroling artery clamp, carries out blood pressure determination, after rabbits blood pressure is stablized, records blood pressure before administration.So
High, medium and low dosage group difference auricular vein injects bilobalide injection 2.5mg/kg, 1.25mg/kg, 0.625mg/kg afterwards
(with the equivalent dose of bilobalide injection clinical application dosage conversions to rabbit), ginkalide A group, ginkolide B group, silver
Apricot lactone C group, Bilobalide group, 1 group of ginkgo lactone composition, 2 groups of ginkgo lactone composition, 3 groups of ginkgo lactone composition, silver
4 groups of apricot lactone composition are injected 1.25mg/kg, positive controls inject enalaprilat injection 0.125mg/kg (with according to
Na Pulila injection clinic common dose is converted to the equivalent dose of rabbit), model control group and Normal group injection life
Salt water is managed, variation and the recovery time of blood pressure are observed.
2.5 observation indexs: mean arterial pressure (+1/3 pulse pressure difference of diastolic pressure), blood pressure decline percentage.
2.6 statistical procedures
It is analyzed using SPSS15.0 statistics software, data are all made of mean+standard deviationIt indicates.It is examined using t
It tests method and carries out statistical analysis and processing, using P < 0.05 as significance of difference standard.
3. experimental result
Table 1, renal hypertension rabbit are depressured experimental result
Model control group P < 0.05 compared with Normal group blood pressure, positive controls, bilobalide injection be high, in,
Low dose group, ginkolide B group, Bilobalide group, 1 group of composition, 2 groups of composition, 3 groups of composition, 4 groups of composition and model
The more equal P < 0.05 of group.
As can be seen from the results, after giving hypertension model rabbit injection bilobalide injection, blood pressure is remarkably decreased immediately, and
Action intensity is in dose dependent, and high dose group has the decline of individual rabbits blood pressures up to 75%, middle dosage bilobalide injection with
Positive control drug Enalapril draws injection antihypertensive effect suitable, and high dose group better effect further looks at, high dose group blood
2 hours blood pressures do not go up pressure upon administration, and blood pressure bottom out in 50 minutes after middle low dose group administration did not restored yet by 2 hours
It is horizontal before to administration；4 groups of ginkolide B group, Bilobalide group, 1 group of composition, 2 groups of composition, 3 groups of composition, composition blood
Pressure also has significant decline, but it can be seen from the table bilobalide injection and the antihypertensive effect of ginkgo lactone composition group compare
It is applied alone the effect of ginkolide B, Bilobalide good.This experimental result is further tested in spontaneous hypertensive rat
Card.
The effect of test example 2, bilobalide injection to spontaneous hypertensive rat blood pressure
1. experiment equipment
1.1 reagents and drug: bilobalide injection (Chengdu Baiyu Pharmaceutical Technology Co., Ltd.'s production, according to having authorized
The method of embodiment two in patent ZL200610103625.6 is made, wherein ginkalide A: ginkolide B: ginkalide C
The weight ratio of=20:30:10, Ginkgolide A. B. C total amount and Bilobalide is 1:1, ginkgolides content: 4.91mg/
Ml), ginkalide A (Chengdu Baiyu Pharmaceutical Technology Co., Ltd. provides, content: 5.0mg/ml), (Chengdu hundred is abundant for ginkolide B
There is provided, content: 5.0mg/ml), ginkalide C (the abundant offer in Chengdu hundred, content: 5.0mg/ml), (Chengdu hundred is abundant to be mentioned Bilobalide
For content: 5.0mg/ml), ginkgo lactone composition 1 (the abundant offer in Chengdu hundred, ginkalide A: ginkolide B: ginkalide C
The weight ratio of=10:5:3, Ginkgolide A. B. C total amount and Bilobalide is 60:5, ginkgolides content: 5.0mg/ml),
Ginkgo lactone composition 2 (the abundant offer in Chengdu hundred, ginkalide A: ginkolide B: ginkalide C=45:5:35, ginkgolides
A, the weight ratio of B, C total amount and Bilobalide is 5:65, ginkgolides content: 5.0mg/ml), ginkgo lactone composition 3 (at
All hundred abundant offers, ginkalide A: ginkolide B: in ginkalide C=10:40:35, Ginkgolide A. B. C total amount and gingko
The weight ratio of ester is 5:10, ginkgolides content: 5.0mg/ml), (the abundant offer in Chengdu hundred, in ginkgo of ginkgo lactone composition 4
Ester A: ginkolide B: the weight ratio of ginkalide C=30:10:10, Ginkgolide A. B. C total amount and Bilobalide is 15:
5, ginkgolides content: 5.0mg/ml), physiological saline, Enalapril draw injection (Changzhou pharmacy).
1.2 laboratory apparatus: the full-automatic rats and mice non-invasive blood pressure measuring system (Chengdu TME Technology Co., Ltd.) of BP-100A
1.3 experimental animals: 16 week old spontaneous hypertensive rats 130 (being provided by Sichuan Province's Experimental Animal Center), body
200~250g is weighed, male and female are unlimited.
2. experimental method
2.1 groupings: 130 spontaneous hypertensive rats are randomly divided into the high, medium and low dosage of bilobalide injection, silver
Apricot lactone A, ginkolide B, ginkalide C, Bilobalide, composition 1, composition 2, composition 3, composition 4, model comparison
Group and positive controls, every group 10.With the equivalent dose 5mg/ of bilobalide injection clinical application dosage conversions to rat
Kg sets each group dosage, wherein high dose group 10mg/kg, middle dose group 5mg/kg, low dosage 2.5mg/kg, ginkalide A group,
Ginkolide B group, ginkalide C group, Bilobalide group, 1 group of ginkgo lactone composition, 2 groups of ginkgo lactone composition, in ginkgo
3 groups of ester composition, 4 groups of ginkgo lactone composition be injected intraperitoneally 5mg/kg, 0.25mg/kg is injected intraperitoneally according to that in positive controls
Puli draws injection (by surface areas conversion is waited between animal), model control group injecting normal saline.
2.2 anesthesia: 1% yellow Jackets (30mg/kg) anesthetized rat is injected intraperitoneally in rat weight.
2.3 blood pressure determinations and administration: rat tail artery systolic pressure is measured with full-automatic rats and mice non-invasive blood pressure measuring system.
The preceding blood pressure of administration is recorded, then gives high, medium and low dosage group SHR rats by intraperitoneal injection various concentration ginkgolides note respectively
Penetrate liquid and intraperitoneal injection ginkolide B group, Bilobalide group, 1 group of composition, 2 groups of composition, 3 groups of composition, composition 4
Group, positive controls inject enalaprilat injection, and model control group rats by intraperitoneal injection physiological saline observes the change of blood pressure
Change and recovery time.
2.5 observation indexs: systolic pressure, blood pressure decline percentage.
2.6 statistical procedures
It is analyzed using SPSS15.0 statistics software, data are all made of mean+standard deviationIt indicates.It is examined using t
It tests method and carries out statistical analysis and processing, using P < 0.05 as significance of difference standard.
3. experimental result
Table 2, spontaneous hypertensive rat are depressured experimental result
Positive controls, ginkolide B group, Bilobalide group, 1 group of composition, 2 groups of composition, 3 groups of composition, combination
4 groups of object, the high, medium and low dosage group of the bilobalide injection equal P < 0.05 compared with model group.
This tests the antihypertensive effect for further demonstrating bilobalide injection, after rat injects bilobalide injection,
Blood pressure declines rapidly, wherein high dose group reduce degree be higher than positive controls, in, low dose group be slightly below positive controls,
Do not go up within high dose group blood pressure 2 hours, blood pressure bottom out after middle low dose group 50 minutes does not recover to administration still after 2 hours
Preceding level, it can thus be appreciated that action intensity that bilobalide injection reduces blood pressure and duration all with the obvious phase of dosage
It closes；4 groups of ginkolide B group, Bilobalide group, 1 group of composition, 2 groups of composition, 3 groups of composition, composition blood pressures also have significantly
Decline, but it can be seen from the table bilobalide injection and the antihypertensive effect of ginkgo lactone composition group than being applied alone in ginkgo
Ester B, the effect of Bilobalide are good.
It can be seen that by two above experiment, ginkolide B, Bilobalide, ginkgo lactone composition and ginkgolides injection
Liquid reduces blood pressure, and the antihypertensive effect of ginkgo lactone composition and bilobalide injection is substantially better than single composition
Ginkolide B and Bilobalide, be used equally for the treatment of hypertension.
Claims (8)
1. the blood-pressure drug containing therapeutically effective amount ginkgolides, which is characterized in that the ginkgolides be ginkalide A,
One or both of ginkolide B, ginkalide C, bilobalide J, ginkgolides M, Bilobalide or more.
2. drug according to claim 1, which is characterized in that the ginkgolides is in ginko diterpenoid lactone and gingko
Ester.
3. drug according to claim 2, which is characterized in that the ginko diterpenoid lactone is selected from ginkalide A, ginkgo
One or both of lactone B, ginkalide C, bilobalide J or ginkgolides M or more.
4. drug according to claim 3, which is characterized in that the ginko diterpenoid lactone: Bilobalide=(5~60)
: (5~65) w/w.
5. drug according to claim 4, which is characterized in that the ginko diterpenoid lactone: Bilobalide=(5: 5) w/
w；Or (5: 65) w/w；Or (60: 5) w/w；Or (5: 10) w/w；Or (15: 5) w/w.
6. drug according to claim 5, which is characterized in that the ginko diterpenoid lactone is selected from one of following combination:
(1) ginkalide A: ginkolide B=(10~45): (5~40) w/w；
(2) ginkalide A: ginkalide C=(10~45): (3~35) w/w；
(3) ginkolide B: ginkalide C=(5~40): (3~35) w/w；
(4) ginkalide A: ginkolide B: ginkalide C=(10~45): (5~40): (3~35) w/w/w.
7. drug according to claim 6, which is characterized in that the dosage matter of three kinds of the Ginkgolide A. B. C combinations
Amount proportion are as follows: ginkalide A: ginkolide B: ginkalide C=20: 30: 10 or 10: 5: 3 or 45: 5: 35 or 10: 40: 35 or
30∶10∶10。
8. the preparation containing any one of the claim 1-7 drug, which is characterized in that the preparation is oral preparation, injection
Preparation or transdermal absorption formulation.
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| CN201410756745.0A CN104688784B (en) | 2013-12-10 | 2014-12-10 | Purposes of the ginkgolides in the drug for preparing blood pressure lowering |
| CN201910318522.9A CN109925310B (en) | 2013-12-10 | 2014-12-10 | Hypotensive agent containing therapeutically effective amount of ginkgolides |
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| CN108096241B (en) * | 2017-11-24 | 2020-06-16 | 江苏康缘药业股份有限公司 | Medical application of ginkgolide composition |
| CN110292637B (en) * | 2018-03-21 | 2022-04-08 | 成都百裕制药股份有限公司 | A pharmaceutical composition for preventing and treating hypertension |
| CN110638902A (en) * | 2019-09-30 | 2020-01-03 | 白冬平 | Application of tomato extract in preparation of antihypertensive drug and antihypertensive composition thereof |
| WO2022183480A1 (en) * | 2021-03-05 | 2022-09-09 | 成都百裕制药股份有限公司 | Pharmaceutical composition containing ginkgolide-type compound and cannabidiol and application thereof in medicine |
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| CN104688784A (en) | 2015-06-10 |
| CN109925310B (en) | 2022-04-08 |
| CN104688784B (en) | 2019-05-28 |
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Denomination of invention: Antihypertensive drugs containing therapeutic effective amount of Ginkgolide Effective date of registration: 20230721 Granted publication date: 20220408 Pledgee: Bank of Shanghai Limited by Share Ltd. Chengdu branch Pledgor: CHENGDU BAIYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980049267 |
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