CN109925018B - Serial plugging chain segment for intratumoral embolism and aneurysm plugging system adopting same - Google Patents
Serial plugging chain segment for intratumoral embolism and aneurysm plugging system adopting same Download PDFInfo
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- CN109925018B CN109925018B CN201910096109.2A CN201910096109A CN109925018B CN 109925018 B CN109925018 B CN 109925018B CN 201910096109 A CN201910096109 A CN 201910096109A CN 109925018 B CN109925018 B CN 109925018B
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Abstract
A serial plugging chain segment for intratumoral embolism and an aneurysm plugging system adopting the same. The aneurysm plugging system comprises serially-connected plugging chain segments for intratumoral embolism and a conveying unit, wherein the serially-connected plugging chain segments for intratumoral embolism comprise plugging units, connecting lines and development positioning marks, the plugging units are fixedly connected by the connecting lines, and the development positioning marks are positioned on the plugging units at intervals of a certain number. The system can effectively avoid the problem that the edge position of a tumor opening cannot be accurately judged due to artifacts generated by a metal plugging instrument under X-rays after plugging, and meanwhile, the plugging unit made of flexible materials can adapt to aneurysms with different calibers by adjusting the size of the plugging unit volume on the premise of keeping the whole compliance of the plugging unit, so that the plugging time is shortened, and the ray intake dose is reduced.
Description
Technical Field
The invention relates to a surgical medical instrument, in particular to a serial plugging chain segment for intratumoral embolism and an aneurysm plugging system adopting the serial plugging chain segment.
Background
Aneurysms, which are the manifestations of localized or diffuse dilatation or bulging of the arterial wall due to lesions or lesions of the arterial wall, mainly manifest as swelling, throbbing masses, can occur in any part of the arterial system, as is common in the trunk arteries of limbs, aorta, carotid artery, intracranial artery. The treatment modes mainly comprise a surgical treatment mode and an interventional treatment mode. The surgical treatment mode mainly comprises the steps of repairing an artery laceration, inhibiting an artery patch and performing artery end-to-end anastomosis, and because superficial skin tissues need to be cut and artery blood vessels are exposed, the operation wound is large, the bleeding amount is large, the time is long, and the recovery of a patient is very unfavorable. The interventional therapy mode mainly comprises a tectorial membrane type artificial intravascular stent implantation, a spring coil embolism, a gel embolism, an occluder embolism and the like. Through interventional therapy, only the surface of the skin needs to be punctured to enter an arterial blood vessel, a corresponding device is conveyed to an aneurysm lesion part through a catheter, the aneurysm is sealed or completely blocked by methods of stent expansion and device embolism, arterial blood is prevented from further entering a aneurysm opening, and normal blood flow direction is recovered. The interventional therapy risk is relatively small, the operation is safer, the complications caused by surgical trauma of the patient are avoided, and the prognosis of the patient is greatly improved.
In current interventional techniques, the devices for treating aneurysms by embolization are mainly coil embolization and gel embolization. The spring ring embolism is not only expensive due to the fact that the platinum spring ring is mainly made of the platinum material, but also can generate certain artifacts in various imaging examinations due to the high radiopacity of the platinum, so that judgment of doctors is influenced, and operation curative effect is reduced. For the gel embolization method, because of a solidification process, the embolization method is only suitable for embolizing intracranial smaller blood vessels, and for embolization of larger aneurysms, the solidification effect and the solidification time greatly limit the size of the embolized aneurysm, so the indication of the gel embolization method has certain limitation.
Disclosure of Invention
In view of the above, the main object of the present invention is to provide a serial blocking segment for intratumoral embolization and an aneurysm blocking system using the same, which are intended to at least partially solve at least one of the above technical problems.
In order to achieve the above object, as an aspect of the present invention, there is provided a serial blocking segment for intratumoral embolization, which is characterized by comprising a plurality of blocking units serially connected by using a blocking unit connecting line, and a development positioning mark disposed on at least one blocking unit and/or the blocking unit connecting line;
wherein the plugging unit is made of a polymer biological porous material.
As another aspect of the present invention, there is provided an aneurysm occlusion system comprising a serial occlusion segment for intratumoral embolization and a delivery unit, wherein:
the series-connection blocking chain segment for intratumoral embolism is the series-connection blocking chain segment for intratumoral embolism as described above;
the conveying unit comprises a conveying conduit and a pushing rod, the conveying conduit is used for accommodating the serial blocking chain segment for intratumoral embolism, and the pushing rod is used for pushing the serial blocking chain segment for intratumoral embolism out of the conveying conduit to enter a blood vessel when needed.
Based on the technical scheme, compared with the prior art, the aneurysm occlusion system has the following beneficial effects:
the problem that the marginal position of a tumor opening cannot be accurately judged due to artifacts generated by a metal plugging instrument under X-rays after plugging can be effectively avoided, and meanwhile, the plugging unit made of flexible materials can adapt to aneurysms with different calibers by adjusting the size of the plugging unit volume on the premise of keeping the whole compliance of the plugging unit, so that the plugging time is shortened, and the ray intake dose is reduced.
Drawings
Fig. 1 is a schematic view of the overall structure of the aneurysm occlusion system of the present invention.
In the above figures, the reference numerals have the following meanings:
1. series plugging unit
1-1, plugging units 1-2, plugging unit serial lines 1-3 and development positioning marks
2. Transport unit
2-1, a conduit 2-2 and a push rod
Detailed Description
In order that the objects, technical solutions and advantages of the present invention will become more apparent, the present invention will be further described in detail with reference to the accompanying drawings in conjunction with the following specific embodiments.
The invention adopts the aneurysm embolization method, adopts the organic biomaterial as the main body of the filler, and simultaneously places the positioning developing marks among the fillers, thereby not only solving the problem of developing and positioning the filler, but also effectively avoiding the problem of artifact interference caused by dense stacking of the developing materials, greatly improving the positioning accuracy and reducing the risk of operation while ensuring the filling effect and improving the filling efficiency, and having incomparable advantages compared with the traditional spring ring embolization and gel embolization.
The serial plugging chain segment is characterized by comprising a plurality of plugging units which are serially connected by adopting a plugging unit connecting line, and a development positioning mark arranged on at least one plugging unit and/or the plugging unit connecting line;
wherein, the plugging unit is made of polymer biological porous material.
Wherein the thickness of the hole wall of the plugging unit is 1-300 μm, the porosity is 5-95%, and preferably 10-90%;
preferably, the plugging unit is made of a degradable polymer biomaterial, and more preferably is polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), Polycaprolactone (PCL), polylactic-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA), or a mixture of two or more of the foregoing substances;
preferably, the plugging unit is made of degradable natural biological materials and derivatives thereof, and more preferably is made of protein, collagen sponge, gelatin, chitosan, fibrin, cellulose and derivatives thereof, or a mixture of two or more of the above substances;
preferably, the material of the plugging unit is an inert biomaterial, and more preferably poly-N-isopropylacrylamide, polyethylene or polytetrafluoroethylene.
The outer contour of the plugging unit can be cylindrical, spherical, oval spherical or conical.
The maximum diameter of the section of the plugging unit in the unexpanded initial state is not larger than the diameter of the inner cavity of a delivery catheter for delivering the plugging unit into a corresponding blood vessel; preferably, the maximum diameter of the cross section of the plugging unit ranges from 1mm to 10 mm.
Wherein, the surface or the interior of the plugging unit contains a vessel wall adhesive material, preferably isobutyl alpha-cyanoacrylate or a derivative thereof; preferably, the doping content of the vessel wall adhesive material is 5% to 50%, preferably 10% to 30%; the doped vessel wall-adhering material is preferably in the form of particles having a particle size of 0.1 to 100 μm, more preferably 1 to 10 μm.
The plugging unit connecting line is made of a bioabsorbable flexible and flexible material, and is preferably polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), Polycaprolactone (PCL), polylactic-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA) and a mixture of two or more of the substances; preferably, the plugging element connecting line is degradable natural biological material and derivatives thereof, and is further preferably protein, collagen sponge, gelatin, chitosan, fibrin, cellulose and derivatives thereof, or a mixture of two or more of the above substances; preferably, the plugging unit connecting line is made of an inert biological material, and further preferably made of poly-N-isopropylacrylamide, polyethylene or polytetrafluoroethylene; preferably, the cross-sectional shape of the plugging unit connecting line is circular, oval or parallelogram.
Preferably, the cross-sectional shapes of the plurality of plugging element connecting lines used in one series-connected plugging segment for intratumoral embolization may be the same or different.
Preferably, the length of the long axis of the cross section of the plugging unit connecting line can be 0.01-3 mm.
Preferably, the length of the plugging unit connecting line between two adjacent plugging units can be 0.1-20 mm.
Wherein, the developing positioning mark is made of one of platinum, gold, palladium, thallium, platinum-iridium alloy and tantalum; preferably, the developing positioning mark is combined with the plugging unit in a coating form or a mosaic form; preferably, the development positioning mark in the mosaic form is designed to be circular or conical; preferably, the development positioning mark in the mosaic form is in a solid or hollow shape and is positioned inside the plugging unit, and the outer surface of the development positioning mark is coated by the plugging unit; preferably, the development positioning marks are located on a certain number of the plugging units spaced at equal intervals from each other.
The invention also discloses an aneurysm plugging system, which takes porous organic biomaterial as a filler main body to prepare plugging units, the plugging units are connected by using a flexible serial line, the plugging units are conveyed to aneurysm parts along the conduits of the matched conveying unit, the plugging units are pushed out of a far-end conduit port to the aneurysm through a pushing rod, and the plugging units expand to a preset size after contacting blood to realize plugging of the aneurysm, and finally, the normal blood flow of a prime artery is recovered.
In a preferred embodiment, the aneurysm occlusion system of the present invention comprises a tandem occlusion unit for intratumoral embolization and a delivery unit. The serial plugging unit for intratumoral embolism consists of a plugging unit, a plugging unit connecting line and a developing and positioning mark. The delivery unit consists of a delivery catheter with a bent head end, an embolism unit pushing cavity, a contrast agent, a guide wire pushing cavity and a pushing rod.
The serial plugging unit for intratumoral embolism comprises a plugging unit, a plugging unit connecting line and a development positioning mark, wherein the plugging unit is made of a polymer biological porous material, the thickness of a hole wall of the plugging unit is 1-300 mu m, and the porosity of the plugging unit is 5-95%.
The polymer biological porous material is a polymer material with good biocompatibility, and the biocompatibility of the polymer biological porous material has the following characteristics: low cytotoxicity, low sensitization, low irritation, low systemic toxicity, no genetic toxicity and carcinogenicity. Preferably, the material has a good blood coagulation effect, so that the aneurysm plugging effect is better. The material used by the plugging unit can be degradable polymer biomaterial, including but not limited to polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), Polycaprolactone (PCL), polylactic-co-caprolactone (PLC), ethylene-co-vinyl acetate (PEVA), polyvinyl alcohol (PVA), and a mixture of two or more thereof; the material used by the plugging unit can be degradable natural biological material and derivative material thereof, including but not limited to protein, collagen sponge, gelatin, chitosan, fibrin, cellulose and derivative thereof, or mixture of two or more of the above; the plugging unit material may be an inert biomaterial including, but not limited to, poly n. isopropylacrylamide, polyethylene, polytetrafluoroethylene.
The cross section of the plugging unit in the direction parallel to the cross section of the catheter is a prototype, the plugging unit can be cylindrical, spherical or oval spherical or conical, the plugging units mutually connected in series can be in the same or different shapes according to actual requirements, can be a combination of one or two or more shapes, can be the same plugging unit or different plugging units in the same shape, and can be in the same or different geometric dimensions. However, each plugging unit in the same series system is in an unexpanded initial state, wherein the maximum diameter of the cross section of each plugging unit cannot be larger than the diameter of the lumen of the delivery catheter of the delivery unit. The maximum diameter range of the cross section of each plugging unit is 1-10 mm. In the process of plugging the aneurysm, plugging units with different shapes and sizes can be selected for plugging according to different aneurysm shape characteristics, so that the stacking density of the plugging units reaches the optimal state, and the gap between the plugging units is reduced to the minimum degree.
In order to improve the adhesion of the occlusion unit to the vessel wall and improve the fixing effect of the occlusion unit in the aneurysm wall, the occlusion unit may preferably be doped with a vessel wall adhesive material, preferably isobutyl alpha-cyanoacrylate and derivatives thereof. The doping proportion of the vessel wall adhesive material can be adjusted according to the size of the aneurysm, the shape and the specific surface area of the used plugging unit, and the selectable doping content is 5-50%, preferably 10-30%. The doped vessel wall adhesive material is granular, and the granularity ranges from 0.1 to 100 mu m, and preferably the granularity ranges from 1 to 10 mu m.
The connecting line between the plugging units is a polymer flexible material with good biocompatibility, and the biocompatibility has the following characteristics: low cytotoxicity, low sensitization, low irritation, low systemic toxicity, no genetic toxicity and carcinogenicity. The material of the connecting wire can be a bioabsorbable flexible material, including but not limited to polylactic acid (PLA), poly (lactic-co-glycolic acid) (PLGA), poly (glycolic acid) (PGA), polyethylene glycol (PEG), Polycaprolactone (PCL), poly (lactic-caprolactone) (PLC), ethylene-vinyl acetate (PEVA), polyvinyl alcohol (PVA), and a mixture of two or more thereof; the material of the connecting line can be degradable natural biological material and derivatives thereof, including but not limited to protein, collagen sponge, gelatin, chitosan, fibrin, cellulose and derivatives thereof, or a mixture of two or more of the above; the material of the connecting wire may be an inert biomaterial including, but not limited to, poly-N-isopropylacrylamide, polyethylene, polytetrafluoroethylene.
The connecting wire can be prepared into different cross-sectional shapes according to the requirements of different plugging units on the pushing performance of the connecting wire, and the cross-sectional shapes are mostly circular, oval or parallelogram, and preferably, the length of the long axis of the cross section is 0.01-3 mm. The length of the connecting line between two adjacent plugging units is 0.1-20 mm. Connecting wires with different cross-sectional shapes and different cross-sectional lengths can be selected according to the shapes and the sizes of the plugging units, so that the optimal matching effect under different plugging unit shapes and different plugging unit sizes is realized, and the optimal pushing performance is achieved.
In order to increase the quantity and the plugging volume of the plugging units in the aneurysm and observe whether the plugging units are still positioned at the aneurysm opening for pushing in real time, the plugging units are developed and confirmed in a way of adding development positioning marks. The developing marking material is one of platinum, gold, palladium, thallium, platinum-iridium alloy and tantalum. The developing positioning mark is positioned on the plugging unit and is tightly combined with the plug unit in a surface coating or embedding mode. The developing mark in a surface coating form is consistent with the shape of the plugging unit and can be designed into a circular ring shape or a conical shape according to the appearance shape of the plugging unit; the embedded developing positioning mark can be in various solid or hollow shapes, and is required to be positioned inside the plugging unit, and the outer surface of the developing positioning mark is coated by the plugging unit. Generally, a first plugging unit at a far end is used as a first developing mark, positioning developing marks are placed at intervals of a certain number of plugging units in a plugging system made of plugging units with the same shape and size, the number of the plugging units entering an aneurysm and the plugging volume of the aneurysm are confirmed by observing the developing positioning marks under X-ray, and whether the aneurysm of the plugging unit is completely plugged or not is judged according to the developing positioning marks. The method for determining the plugging effect has the obvious advantages compared with the traditional spring ring positioning and developing mark, not only can determine the plugging position, but also can effectively avoid artifacts caused by overlarge metal stacking density, thereby accurately identifying whether the aneurysm opening is completely sealed and whether the aneurysm body is completely embolized.
In the aneurysm occlusion system, the delivery unit used in cooperation comprises a catheter and a push rod, wherein the catheter is a plastic thin-wall catheter which comprises stainless steel braided wires and has a certain bent shape at the head end or a plastic thin-wall tube with certain hardness and strength. The stainless steel braided wire mainly provides a certain hardness support for the catheter, improves the bending resistance of the plastic catheter, and ensures that the catheter has corresponding pushing performance and good twisting control performance. The plastic thin-wall catheter material is preferably one of TPU, PVC, PE, PP, PA, PEBAX, TPE and PC.
The push rod of the conveying unit can be a stainless steel coil spring lead screw, and the outer diameter of the push rod is consistent with the inner diameter of the guide pipe of the conveying unit. The pushing rod of the conveying unit can be a plastic conduit or a plastic conduit with stainless steel braided wires, and the outer diameter of the pushing rod is consistent with the inner diameter of the conduit of the conveying unit.
The technical solution of the present invention is further explained below with reference to the specific embodiments and the accompanying drawings.
The invention describes an aneurysm plugging system, and figure 1 is a schematic overall structure diagram of the aneurysm plugging system. As shown in fig. 1, the aneurysm occlusion system comprises two parts, a tandem occlusion unit 1 and a delivery unit 2. The serial plugging unit comprises a plugging unit 1-1, a plugging unit serial line 1-2 and a developing positioning mark 1-3. The conveying unit comprises a guide pipe 2-1 and a pushing rod 2-2.
The plugging units 1 are connected in series, the plugging units 1-1 are connected at equal intervals by a series connection line 1-2, the positioning development marks 1-3 are positioned inside the plugging units 1-1 or coated on the outer surfaces of the plugging units 1-1 and are arranged at equal intervals to serve as development marks of the whole plugging units, and the plugging volume of the plugging units entering the aneurysm can be confirmed at any time. In the operation process, after a delivery catheter 2-1 with a proper bent head end is placed at a tumor opening part under rays, the plugging units are pushed out of a catheter cavity one by a push rod to enter an aneurysm, so that the plugging units rapidly absorb water and expand to a preset volume in blood, the volume of the plugging units 1-1 entering the aneurysm is determined by monitoring the positions of developing and positioning marks 1-3 in real time, and the total volume of the plugging units is ensured to be matched with the predicted volume of the aneurysm. Finally, after the whole aneurysm is completely blocked, the matched conveying unit 2 is withdrawn to the outside of the body, and the aneurysm blocking is completed.
Example 1
An aneurysm plugging system is composed of serially connected plugging units for intratumoral embolism and a conveying unit thereof. The serial plugging unit for intratumoral embolism consists of a plugging unit, a plugging unit connecting line and a developing and positioning mark. The plugging unit adopts cylindrical collagen sponge, the initial size of the plugging unit cylinder is 2.5mm in section diameter and 2.5mm in length, the porosity of the material is 50%, and the average thickness of the hole wall is 100 microns. The plugging units are formed by connecting chitosan fibers in series, the distance between every two adjacent plugging units is 2.5mm, the number of each plugging unit is 11, the outer surfaces of the 1 st, 6 th and 11 th plugging units at the far ends are coated with platinum developing and positioning marks, the platinum developing and positioning marks are circular rings, the outer diameter of each plugging unit is 2.5mm, the wall thickness of each plugging unit is 0.1mm, the length of each plugging unit is 1mm, and the plugging units are located in the middle of the plugging units and are tightly matched with the plugging units. The conveying unit matched with the series plugging unit is an 8F conveying catheter, namely the inner diameter of the conveying catheter is 2.5mm, the main body material of the conveying catheter is PEBAX 7233, 6 strands of stainless steel braided wires are contained in the conveying catheter, the bent part at the head end of the conveying catheter is PEBAX 7233, the conveying catheter and the PRBAX catheter are welded together, and the pushing performance and the flexibility of the head end of the conveying catheter passing through a blood vessel and reaching an aneurysm opening are further improved.
Example 2
An aneurysm plugging system is composed of serially connected plugging units for intratumoral embolism and a conveying unit thereof. The serial plugging unit for intratumoral embolism consists of a plugging unit, a plugging unit connecting line and a developing and positioning mark. The plugging unit adopts cylindrical collagen sponge and ellipsoidal fibrin, the initial size of the plugging unit cylinder is 1.5mm in section diameter and 1.5mm in length, the porosity of the material is 20%, and the average thickness of the hole wall is 150 μm. The ellipsoidal fibrous protein has a major axis of 2mm and a minor axis of 1.5mm, the porosity of the material is 20%, and the average thickness of the pore wall is 150 μm. The plugging units are formed by serially connecting polylactic acid-glycolic acid copolymer (PLGA), the distance between every two adjacent plugging units is 1.5mm, the number of each plugging unit string is 13, the inner surfaces of the 1 st, 7 th and 13 th plugging units at the far ends are embedded with tantalum development positioning marks, the positioning and development marks are spherical, the outer diameter of the positioning and development marks is 0.5mm, and the positioning and development marks are positioned in the middle of the plugging units. The outer surface of each plugging unit was coated with isobutyl alpha-cyanoacrylate in a thickness of 5 μm. The conveying unit matched with the series plugging unit is a conveying catheter of 5F, namely the inner diameter of the conveying catheter is 1.5mm, the main body material of the conveying catheter is PEBAX, 6 strands of stainless steel braided wires are contained in the conveying catheter, the head end bending part of the conveying catheter is PEBAX 7233, the conveying catheter is welded with the PRBAX catheter main body of the stainless steel braided wires, and the pushing performance and the flexibility of the head end of the conveying catheter passing through a blood vessel and reaching an aneurysm opening are further improved.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. A serial plugging chain segment for intratumoral embolism is characterized by comprising a plurality of plugging units which are serially connected by adopting a plugging unit connecting line and a development positioning mark arranged on at least one plugging unit and/or the plugging unit connecting line;
wherein the plugging unit is made of a polymer biological porous material;
the thickness of the hole wall of the plugging unit is 1-300 mu m, and the porosity is 20% -50%;
the plugging unit is made of a degradable polymer biomaterial, and the degradable polymer biomaterial comprises polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), Polycaprolactone (PCL), polylactic-caprolactone copolymer (PLC), ethylene-vinyl acetate copolymer (PEVA), polyvinyl alcohol (PVA) or a mixture of more than two of the substances; or the plugging unit is made of degradable natural biological materials and derivatives thereof, wherein the degradable natural biological materials and derivatives thereof comprise collagen sponge, gelatin, chitosan, fibrin, cellulose and derivatives thereof, or a mixture of more than two of the substances; or the plugging unit is made of an inert biological material, wherein the inert biological material comprises poly-N-isopropylacrylamide, polyethylene or polytetrafluoroethylene;
the plugging unit is cylindrical, spherical, oval spherical or conical;
the maximum diameter of the section of the plugging unit in the unexpanded initial state is not larger than the diameter of the inner cavity of a delivery catheter used for delivering the plugging unit into the corresponding blood vessel;
the maximum diameter of the initial section of the plugging unit is 10 mm;
the surface or the interior of the plugging unit contains a blood vessel wall adhesive material which comprises isobutyl alpha-cyanoacrylate or a derivative thereof;
the doping content of the vessel wall adhesive material is 10% -30%;
the doped vessel wall adhesive material is granular, and the granularity range is 1-10 mu m;
the plugging unit connecting line is made of a bioabsorbable flexible material, and the bioabsorbable flexible material comprises polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polyglycolic acid (PGA), polyethylene glycol (PEG), Polycaprolactone (PCL), polylactic-co-caprolactone (PLC), ethylene-co-vinyl acetate (PEVA), polyvinyl alcohol (PVA) and a mixture of more than two of the substances; or the plugging unit connecting line is a degradable natural biological material and a derivative thereof, and the degradable natural biological material and the derivative thereof comprise collagen sponge, gelatin, chitosan, fibrin, cellulose and a derivative thereof, or a mixture of more than two of the substances; or the plugging unit connecting line is made of an inert biological material, and the inert biological material comprises poly-N-isopropylacrylamide, polyethylene or polytetrafluoroethylene;
the cross section of the plugging unit connecting line is circular, oval or parallelogram;
in one serial plugging chain segment for intratumoral embolism, the cross sections of the adopted connecting lines of the plugging units are the same or different;
the length of a long axis of the section of the plugging unit connecting line is 0.01-3 mm;
the length of a connecting line of the plugging units between two adjacent plugging units is 0.1-20 mm;
the developing positioning mark is made of one material selected from platinum, gold, palladium, thallium, platinum-iridium alloy and tantalum;
the developing positioning mark is combined with the plugging unit in a coating mode or a mosaic mode;
the mosaic type developing positioning mark is designed into a circular ring shape or a conical shape;
the development positioning mark in the mosaic form is in a solid or hollow shape, is positioned inside the plugging unit, and the outer surface of the development positioning mark is coated by the plugging unit;
the developing positioning marks are positioned on the plugging units which are spaced at equal intervals and are a certain number.
2. An aneurysm occlusion system comprising series-connected occlusion segments for intratumoral embolization and delivery units, wherein:
the series-connection blocking chain segment for intratumoral embolism is the series-connection blocking chain segment for intratumoral embolism according to claim 1;
the conveying unit comprises a conveying conduit and a pushing rod, the conveying conduit is used for accommodating the serial blocking chain segment for intratumoral embolism, and the pushing rod is used for pushing the serial blocking chain segment for intratumoral embolism out of the conveying conduit to enter a blood vessel when needed.
3. The aneurysm occlusion system of claim 2, wherein the delivery catheter is a plastic catheter or a plastic catheter with stainless steel braided wires, further a plastic thin-walled catheter with a certain curve at the tip containing the stainless steel braided wires;
the plastic thin-wall conduit is made of TPU, PVC, PE, PP, PA, PEBAX, TPE or PC.
4. The aneurysm occlusion system of claim 2, wherein the pusher rod of the delivery unit is a stainless steel coil spring lead screw of the variable bend type.
5. The aneurysm occlusion system of claim 2, wherein the push rod has an outer diameter that conforms to an inner diameter of a delivery catheter in the delivery unit.
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| JP2018534956A (en) * | 2015-09-10 | 2018-11-29 | イコナノ ベンチャー パートナーズ， エルエルシー | Polymer electrospun embolization device and method of use |
| CN207870917U (en) * | 2017-04-10 | 2018-09-18 | 深圳麦普奇医疗科技有限公司 | A kind of degradable spring ring of intravascular intervention medical use |
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| CN106068107A (en) * | 2014-01-10 | 2016-11-02 | 南洋理工大学 | Embolization device, apparatus for thromboembolism target vessel position and method thereof |
| CN109195533A (en) * | 2016-05-31 | 2019-01-11 | 国立大学法人信州大学 | Embolic coil |
| CN208388681U (en) * | 2017-08-01 | 2019-01-18 | 李新伟 | H/N tumors Jugular sex megrims device |
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