CN109916815A - A kind of medicament screening apparatus based on SPR - Google Patents
A kind of medicament screening apparatus based on SPR Download PDFInfo
- Publication number
- CN109916815A CN109916815A CN201910205967.6A CN201910205967A CN109916815A CN 109916815 A CN109916815 A CN 109916815A CN 201910205967 A CN201910205967 A CN 201910205967A CN 109916815 A CN109916815 A CN 109916815A
- Authority
- CN
- China
- Prior art keywords
- flow cell
- clamping joint
- feed liquor
- rotating cylinder
- apparatus based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 22
- 238000012216 screening Methods 0.000 title claims abstract description 19
- 230000003287 optical effect Effects 0.000 claims abstract description 35
- 238000007689 inspection Methods 0.000 claims abstract description 12
- 238000005070 sampling Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 16
- 230000005540 biological transmission Effects 0.000 claims description 13
- 239000002699 waste material Substances 0.000 claims description 13
- 230000003139 buffering effect Effects 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 238000007877 drug screening Methods 0.000 abstract description 9
- 230000007246 mechanism Effects 0.000 abstract description 8
- 239000012491 analyte Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Abstract
The invention discloses a kind of medicament screening apparatus based on SPR, including shell, feed liquor system, Systems for optical inspection and automatic switchover system；Systems for optical inspection is equipped in the shell, Systems for optical inspection includes optical detecting module and host computer；The automatic switchover system includes the rotating cylinder frame being set on the outside of optical detecting module, and rotating cylinder frame is rotatably connected to fixing axle；The nested mounting groove being circumferentially distributed is distributed in the rotating cylinder frame, and nested mounting groove is embedded to be cased with flow cell, is equipped with sensor chip in the flow cell.The present invention passes through the rotating cylinder frame for being equipped with and being used to the fixed flow cell being circumferentially distributed, and Geneva mechanism realizes the replacement of flow cell, and then realizes the replacement of targeted molecular, improves the efficiency of drug screening；By be equipped with left connection clamping joint, right connection clamping joint, sliding shoe and Bidirectional-screw, facilitate carry out flow cell be connected to being connected and disconnected from for clamping joint, facilitate progress flow cell synchronize replace.
Description
Technical field
The present invention relates to drug screening device field, specifically a kind of medicament screening apparatus based on SPR.
Background technique
Surface plasma resonance (SPR) is a kind of optical phenomena, can be used to real-time tracking biology point under native state
Interaction between son.This method, without any damage, and is not required to any marker to biomolecule.
A kind of biomolecule (target molecule) is first bonded in biosensor surface, then another energy and target molecule will be contained
The solution for generating the biomolecule (analyte) of interaction injects and flows through biosensor surface.Combination between biomolecule
The increase for causing biosensor surface quality causes refractive index to enhance in same ratio, the change reacted between biomolecule
Change and is observed.With reacton (RU) Lai Hengliang: 1RU=1pg albumen/mm2=1x10-6RIU, (refraction refers to for this reaction
Number unit).
Analyte is flowed through interactive surfaces by convection current and diffusion and is formed with target molecule compound during being injected
Object causes analyte concentration to change.The application of nL order of magnitude flow channel in microfluidic systems, so that the change of this concentration is dropped
To minimum point, to ensure high mass tranfer coefficient.To guarantee that the mass transfer performances of analyte are not limited, it is bonded in biosensor surface
Concentration of target molecules must be lower.When analyte is injected, analyte-target complexes are formed in biosensor surface,
Lead to increased response.And after analyte is injected, analyte-target complexes dissociation leads to habituation.Pass through
Convolution interaction model is fitted this response curve, and kinetic constant can be determined.And non-specific binding and total folding
Penetrating the effects such as index phase shift can then be driven away by referring to curve subduction function.
The detection efficiency of existing surface plasmon resonance assay instrument is not high, is in drug screening process, needs hand
Dynamic replacement contains the sensor chip of different targeted moleculars, troublesome in poeration, causes drug screening inefficiency.
Summary of the invention
The purpose of the present invention is to provide a kind of medicament screening apparatus based on SPR, to solve to mention in above-mentioned background technique
Out the problem of.
To achieve the above object, the invention provides the following technical scheme:
A kind of medicament screening apparatus based on SPR, including shell, feed liquor system, Systems for optical inspection and automatic switchover system
System；
Systems for optical inspection is equipped in the shell, Systems for optical inspection includes optical detecting module and host computer；It is described
Automatic switchover system includes the rotating cylinder frame being set on the outside of optical detecting module, and rotating cylinder frame is rotatably connected to fixing axle；Described turn
The nested mounting groove being circumferentially distributed is distributed in tub, and nested mounting groove is embedded to be cased with flow cell；Connection on the left of the flow cell
There is microjet pipe, microjet pipe clamp is connected to left connection clamping joint；It is communicated with outlet tube on the right side of the flow cell, outlet tube is connected with
Right connection clamping joint；The left connection clamping joint is fixedly connected to sliding shoe with the right clamping joint upper end that is connected to, and slides block nesting
There is sliding rail frame, sliding rail frame is fixedly connected with the casing；Through there is Bidirectional-screw, Bidirectional-screw is connected the sliding shoe by shaft coupling
There is lead screw motor；Sensor chip is equipped in the flow cell.
As a further solution of the present invention: sheave being connected with by connecting rod on the right side of the rotating cylinder frame, sheave is socketed in
It is rotatablely connected in fixing axle and with fixing axle；The sheave is connected with cutaway disk, and cutaway disk is fixedly connected with rotation axis, turns
Moving axis and inner walls are rotatablely connected；The rotation axis is connected with transmission shaft by the first driving gear set, and transmission shaft passes through the
Two driving gear sets are connect with Bidirectional-screw.
As a further solution of the present invention: first driving gear set includes in diagonal symmetrical one group of half range cone
Gear, half range bevel gear are sleeved and fixed with rotation axis, and half range bevel gear upper end is ratcheting master bevel gear, master bevel gear and biography
Moving axis is fixedly connected, and the second driving gear set includes one group of bevel gear for being mutually perpendicular to suit.
As a further solution of the present invention: the optical detecting module and host computer are electrically connected, optical detecting module
Including laser emitter, laser pickoff.
As a further solution of the present invention: being equipped with flexible clamping block in the nesting mounting groove.
As a further solution of the present invention: the microjet pipe is equipped with first passage and second channel, left connection clamping
Head is fixedly connected with feed liquor casing, and feed liquor casing is embedded to be cased with the first feed liquor branch pipe and the second feed liquor branch pipe, the first feed liquor branch pipe
It is connected to first passage, the first feed liquor branch pipe is communicated with the first sampling pump, and the first sampling pump is connected to sample jar；Described second into
Liquid branch pipe is communicated with the second sampling pump, and the second sampling pump is communicated with buffering flow container.
As a further solution of the present invention: the outlet tube is equipped with third channel, and right connection clamping joint is communicated with waste liquid
Discharge pipe, waste liquid discharge pipe are communicated with waste liquid tank.
Compared with prior art, the beneficial effects of the present invention are: the present invention, which passes through to be equipped with, is used to what fixation was circumferentially distributed
The rotating cylinder frame of flow cell, Geneva mechanism realizes the replacement of flow cell, and then realizes the replacement of targeted molecular, improves drug screening
Efficiency；By being equipped with left connection clamping joint, right connection clamping joint, sliding shoe and Bidirectional-screw, facilitates and carry out flow cell and company
Logical clamping joint is connected and disconnected from, and facilitates the synchronous replacement for carrying out flow cell.
Detailed description of the invention
Fig. 1 is the schematic diagram of internal structure of the medicament screening apparatus based on SPR；
Fig. 2 is the top view of nested mounting groove in the medicament screening apparatus based on SPR；
Fig. 3 is the structural schematic diagram of feed liquor system in the medicament screening apparatus based on SPR；
Fig. 4 is the structural schematic diagram of Geneva mechanism in the medicament screening apparatus based on SPR；
Fig. 5 is the enlarged drawing in Fig. 1 at A.
In figure: 1- shell；2- rotating cylinder frame；3- nesting mounting groove；301- flexible clamping block；4- flow cell；5- microjet pipe；
501- first pipe；502- second pipe；6- outlet tube；601- third pipeline；7- fixing axle；8- optical detecting module；On 9-
Position machine；10- left connection clamping joint；11- feed liquor casing；12- the first feed liquor branch pipe；The first sampling pump of 13-；14- sample jar；15
Two feed liquor branch pipes；16 second sampling pumps；17 buffering flow containers；18 right connection clamping joints；19 waste liquid discharge pipes；20- waste liquid tank；21-
Sliding shoe；22- Bidirectional-screw；23- lead screw motor；24- sheave；25- connecting rod；26- cutaway disk；27- rotation axis；28-
One driving gear set；29- transmission shaft；The second transmission gear of 30-.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
Please refer to Fig. 1-5, in the embodiment of the present invention, a kind of medicament screening apparatus based on SPR, including shell 1, feed liquor system
System, Systems for optical inspection and automatic switchover system；It is equipped with Systems for optical inspection in the shell 1, Systems for optical inspection includes light
Detection module 8 and host computer 9 are learned, optical detecting module 8 and host computer 9 are electrically connected, and optical detecting module 8 will test signal biography
Host computer 9 is transported to, the fitting of curve is carried out, optical detecting module 8 and host computer 9 are the prior art, optical detecting module packet
Laser emitter, laser pickoff are included, laser emitter, laser pickoff are the prior art, and the application is not repeating.
The optical detecting module 8 is fixedly connected with fixing axle 7, and automatic switchover system includes being set in optical detecting module
The rotating cylinder frame 2 in 8 outsides, optical detecting module 8 are nested in rotating cylinder frame 2, and rotating cylinder frame 2 and fixing axle 7 are rotatablely connected；The rotating cylinder
Frame 2 is hollow tubular structure, and the nested mounting groove 3 being circumferentially distributed is distributed in rotating cylinder frame 2, and nested mounting groove 3 is embedded to be cased with stream
Logical pond 4, nested mounting groove 3 is interior to be equipped with flexible clamping block 301, easy to disassemble and replacement flow cell 4.
Microjet pipe 5 is communicated on the left of the flow cell 4, microjet pipe 5 is equipped with first passage 501 and second channel 502；
The microjet pipe 5 is connected with left connection clamping joint 10, and left connection clamping joint 10 is fixedly connected with feed liquor casing 11, feed liquor casing
11 it is embedded be cased with the first feed liquor branch pipe 12 and the second feed liquor branch pipe 15, the first feed liquor branch pipe 12 is connected to first passage 501, first
Feed liquor branch pipe 12 is communicated with the first sampling pump 13, and the first sampling pump 13 is connected to sample jar 14, realizes the pumping to candidate drug liquid
It takes；The second feed liquor branch pipe 15 is communicated with the second sampling pump 16, and the second sampling pump 16 is communicated with buffering flow container 17, to buffer
It is extracted, sensor chip is rinsed.
Outlet tube 6 is communicated on the right side of the flow cell 4, outlet tube 6 is equipped with third channel 601；The outlet tube 6 is connected with
Right connection clamping joint 18, right connection clamping joint 18 are communicated with waste liquid discharge pipe 19, and waste liquid discharge pipe 19 is communicated with waste liquid tank 20, right
Waste liquid is collected.
The left connection clamping joint 10 is fixedly connected to sliding shoe 21 with right 18 upper end of clamping joint that is connected to, and sliding shoe 21 is embedding
It is cased with sliding rail frame, sliding rail frame is fixedly connected with shell 1；Through there is Bidirectional-screw 22, Bidirectional-screw 22 passes through the sliding shoe 21
Shaft coupling is connected with lead screw motor 23, and lead screw motor 23 is fixedly connected with 1 inner wall of shell and connect with host computer 9, controlled,
Lead screw motor 23 drives Bidirectional-screw 22 to rotate and reverse, and Bidirectional-screw 22 drives sliding shoe 21 opposite or movement backwards, when
Backwards to mobile, left connection clamping joint 10 and right connection clamping joint 18 are detached from flow cell 4 sliding shoe 21, i.e., microjet pipe 5 and
First feed liquor branch pipe 12 and the second feed liquor branch pipe 15 disconnect, and outlet tube 6 and waste liquid discharge pipe 19 disconnect.
It is equipped with sensor chip in the flow cell 4, the biomolecule (target for the sensor core on piece coupling being circumferentially distributed
To molecule) it is all different, it can be convenient the switching of progress targeted molecular by rotating rotating cylinder frame 2, have to drug in analysis liquid
It imitates substance and carries out high frequency zone, improve drug screening efficiency.
Embodiment 2
The present embodiment the difference from embodiment 1 is that: sheave 24 is connected with by connecting rod 25 on the right side of the rotating cylinder frame 2,
Sheave 24 is socketed in fixing axle 7 and is rotatablely connected with fixing axle 7；The sheave 24 is connected with cutaway disk 26,24 He of sheave
Cutaway disk 26 constitutes the Geneva mechanism of intermittent rotary, and cutaway disk 26 is fixedly connected with rotation axis 27, rotation axis 27 and shell
The rotation connection of 1 inner wall of body；The rotation axis 27 is connected with transmission shaft 29 by the first driving gear set 28, and transmission shaft 29 passes through the
Two driving gear sets 30 connect transmission with Bidirectional-screw 22；First driving gear set 28 includes in symmetrical one group diagonal
Half range bevel gear, half range bevel gear are sleeved and fixed with rotation axis 27, and half range bevel gear upper end is ratcheting master bevel gear, standard cone
Gear is fixedly connected with transmission shaft 29, and the second driving gear set 30 includes one group of bevel gear for being mutually perpendicular to suit；Bidirectional-screw
When 22 drive transmission shafts 29 are rotated forward or inverted, rotation axis 27 is driven to turn to constant turn by the first driving gear set 28
It is dynamic, it realizes the operation of Geneva mechanism, and then rotating cylinder frame 2 is driven to rotate, realizes the switching of flow cell 4, and then realize targeted molecular
Switching, improve drug screening efficiency.
The working principle of the invention: host computer 9 drives the second sampling pump 16, buffer is evacuated in flow cell 4, to circulation
Pond is rinsed, and closes the second sampling pump 16, is started the first sampling pump 14, is extracted in drug solution to flow cell to be measured, is started
Optical detecting module 8, optical detecting module 8 send data to host computer 9, carry out curve fitting, and judge drug effectiveness, the
After primary screening, host computer 9 starts lead screw motor 23, and lead screw motor 23 drives Bidirectional-screw 22 to rotate forward, and drives sliding shoe
21 backwards to movement, and then left connection clamping joint 10 and right connection clamping joint 18 is driven to disconnect with flow cell 4, simultaneously bi-directionally silk
Bar 22 drives rotation axis 27 to rotate by transmission shaft 29, and then drives Geneva mechanism rotation, and rotating cylinder frame 2 is driven to rotate, so that under
One flow cell 4 turns between left connection clamping joint 10 and right connection clamping joint 18, and lead screw motor 23 drives Bidirectional-screw anti-
Above-mentioned step is repeated to rotation so that left connection clamping joint 10 and right connection clamping joint 18 are connected to after being clamped with new flow cell 4
Suddenly, the flow cell 4 being circumferentially distributed successively is replaced, carries out optical detection and data collection, and then improve the efficiency of drug screening.
It should be noted that: optical detecting module, sampling pump, host computer, flow cell, sensor chip in the application
For the prior art；Left connection clamping joint, right connection clamping joint, sliding shoe, Bidirectional-screw, transmission shaft, rotation axis, Geneva mechanism,
Rotating cylinder frame is the innovative point of the application；It is used to the rotating cylinder frame of the fixed flow cell being circumferentially distributed by being equipped with, Geneva mechanism is real
The replacement of existing flow cell, and then realize the replacement of targeted molecular, improve the efficiency of drug screening；It is clamped by being equipped with left connection
Head, right connection clamping joint, sliding shoe and Bidirectional-screw, facilitate carry out flow cell be connected to being connected and disconnected from for clamping joint, facilitate
Carry out the synchronous replacement of flow cell.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.Any reference signs in the claims should not be construed as limiting the involved claims.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (7)
1. a kind of medicament screening apparatus based on SPR, including shell (1), feed liquor system, Systems for optical inspection and automatic switchover system
System；It is characterized in that, the shell (1) in be equipped with Systems for optical inspection, Systems for optical inspection include optical detecting module (8) and
Host computer (9)；The automatic switchover system includes the rotating cylinder frame (2) being set on the outside of optical detecting module (8), rotating cylinder frame (2)
It is rotatably connected to fixing axle (7)；The nested mounting groove (3) being circumferentially distributed, nested mounting groove is distributed in the rotating cylinder frame (2)
(3) it embeds and is cased with flow cell (4)；It is communicated with microjet pipe (5) on the left of the flow cell (4), microjet pipe (5) is connected with left company
Logical clamping joint (10)；It is communicated with outlet tube (6) on the right side of the flow cell (4), outlet tube (6) is connected with right connection clamping joint
(18)；The left connection clamping joint (10) is fixedly connected to sliding shoe (21), sliding shoe with right clamping joint (18) upper end that is connected to
(21) it is nested with sliding rail frame, sliding rail frame is fixedly connected with shell (1)；The sliding shoe (21), which is run through, to be had Bidirectional-screw (22), double
Lead screw motor (23) are connected with by shaft coupling to screw rod (22)；Sensor chip is equipped in the flow cell (4).
2. a kind of medicament screening apparatus based on SPR according to claim 1, which is characterized in that the rotating cylinder frame (2) is right
Side is connected with sheave (24) by connecting rod (25), and sheave (24), which is socketed on fixing axle (7) and rotates with fixing axle (7), to be connected
It connects；The sheave (24) is connected with cutaway disk (26), and cutaway disk (26) is fixedly connected with rotation axis (27), rotation axis (27)
It is rotatablely connected with shell (1) inner wall；The rotation axis (27) is connected with transmission shaft (29) by the first driving gear set (28), is passed
Moving axis (29) is connect by the second driving gear set (30) with Bidirectional-screw (22).
3. a kind of medicament screening apparatus based on SPR according to claim 2, which is characterized in that first driving cog
Wheel group (28) includes in diagonal symmetrical one group of half range bevel gear, and half range bevel gear is sleeved and fixed with rotation axis (27), half range
Bevel gear upper end is ratcheting master bevel gear, and master bevel gear is fixedly connected with transmission shaft (29), the second driving gear set (30)
Including one group of bevel gear for being mutually perpendicular to suit.
4. a kind of medicament screening apparatus based on SPR according to claim 1, which is characterized in that the optical detection mould
Block (8) and host computer (9) are electrically connected, and optical detecting module (8) includes laser emitter, laser pickoff.
5. a kind of medicament screening apparatus based on SPR according to claim 1, which is characterized in that the nesting mounting groove
(3) flexible clamping block (301) are equipped in.
6. a kind of medicament screening apparatus based on SPR according to claim 1, which is characterized in that the microjet pipe (5)
Equipped with first passage (501) and second channel (502), left connection clamping joint (10) is fixedly connected with feed liquor casing (11), feed liquor
Casing (11) is embedded to be cased with the first feed liquor branch pipe (12) and the second feed liquor branch pipe (15), the first feed liquor branch pipe (12) and first passage
(501) it is connected to, the first feed liquor branch pipe (12) is communicated with the first sampling pump (13), and the first sampling pump (13) and sample jar (14) are even
It is logical；The second feed liquor branch pipe (15) is communicated with the second sampling pump (16), and the second sampling pump (16) is communicated with buffering flow container (17).
7. a kind of medicament screening apparatus based on SPR according to claim 1, which is characterized in that the outlet tube (6) sets
Have third channel (601), right connection clamping joint (18) is communicated with waste liquid discharge pipe (19), and waste liquid discharge pipe (19) is communicated with waste liquid
Tank (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910205967.6A CN109916815B (en) | 2019-03-18 | 2019-03-18 | Drug screening device based on SPR |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910205967.6A CN109916815B (en) | 2019-03-18 | 2019-03-18 | Drug screening device based on SPR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109916815A true CN109916815A (en) | 2019-06-21 |
| CN109916815B CN109916815B (en) | 2021-08-10 |
Family
ID=66965586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910205967.6A Active CN109916815B (en) | 2019-03-18 | 2019-03-18 | Drug screening device based on SPR |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109916815B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006090758A (en) * | 2004-09-21 | 2006-04-06 | Fuji Photo Film Co Ltd | Sensor in utilizing attenuated total reflection |
| CN101694464A (en) * | 2009-10-23 | 2010-04-14 | 中国科学院化学研究所 | Surface plasma resonance imaging analyzer |
| CN104237131A (en) * | 2014-10-11 | 2014-12-24 | 重庆医科大学 | Flow cell |
| CN206506239U (en) * | 2017-02-14 | 2017-09-19 | 中铁第四勘察设计院集团有限公司 | A kind of buckle-type cable, communications rack |
| CN108680505A (en) * | 2018-07-09 | 2018-10-19 | 大连理工大学 | A kind of multi-channel wavelength modulation type optical fiber detecting system |
| CN108760688A (en) * | 2018-02-13 | 2018-11-06 | 中国人民解放军91054部队 | A kind of detection and identification device of underwater micro- trace chemical |
| CN208350613U (en) * | 2018-07-09 | 2019-01-08 | 大连理工大学 | A kind of multi-channel wavelength modulation type optical fiber detection system |
-
2019
- 2019-03-18 CN CN201910205967.6A patent/CN109916815B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006090758A (en) * | 2004-09-21 | 2006-04-06 | Fuji Photo Film Co Ltd | Sensor in utilizing attenuated total reflection |
| CN101694464A (en) * | 2009-10-23 | 2010-04-14 | 中国科学院化学研究所 | Surface plasma resonance imaging analyzer |
| CN104237131A (en) * | 2014-10-11 | 2014-12-24 | 重庆医科大学 | Flow cell |
| CN206506239U (en) * | 2017-02-14 | 2017-09-19 | 中铁第四勘察设计院集团有限公司 | A kind of buckle-type cable, communications rack |
| CN108760688A (en) * | 2018-02-13 | 2018-11-06 | 中国人民解放军91054部队 | A kind of detection and identification device of underwater micro- trace chemical |
| CN108680505A (en) * | 2018-07-09 | 2018-10-19 | 大连理工大学 | A kind of multi-channel wavelength modulation type optical fiber detecting system |
| CN208350613U (en) * | 2018-07-09 | 2019-01-08 | 大连理工大学 | A kind of multi-channel wavelength modulation type optical fiber detection system |
Non-Patent Citations (1)
| Title |
|---|
| 刘闯 等: "表面等离子共振技术SPR综述", 《豆丁网HTTPS://WWW.DOCIN.COM/P-2018555434.HTML》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109916815B (en) | 2021-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106706942B (en) | Automatic analysing apparatus and method of sample analysis | |
| AU768861B2 (en) | Reversible-flow conduit system | |
| Preinerstorfer et al. | Advances in enantioselective separations using electromigration capillary techniques | |
| WO2018045953A1 (en) | Micro-droplet fluorescence detection system | |
| Abrantes et al. | Adaptation of a surface plasmon resonance biosensor with microfluidics for use with small sample volumes and long contact times | |
| CN1293757A (en) | Refractometer and method for qualitative and quantitive measurements | |
| US20090142845A1 (en) | Flow reactor method and apparatus | |
| US20210178290A1 (en) | Systems and method for detection of analytes in high volumetric flow applications | |
| CN102326086A (en) | Automatic analytical device | |
| JP5041153B2 (en) | Separation device | |
| CN104535776A (en) | Immune scatter turbidimetry based full-automatic detection device and method thereof | |
| JP2006527365A5 (en) | ||
| JP5444005B2 (en) | Fluid focusing for specimen position control for 3D image formation (FLUIDFOCUSING) | |
| CN101776668A (en) | Filling method of C18 HPLC (High Performance Liquid Chromatography) column | |
| CN205576142U (en) | Unimolecule gene sequencer | |
| CN106334343A (en) | Preparation method and application of agarose bonded silica gel hybridized monolithic column | |
| CN107167435B (en) | Centrifugal separation device and method based on microfluidic photometric detection | |
| CN109916815A (en) | A kind of medicament screening apparatus based on SPR | |
| CN201464478U (en) | Improved detection device | |
| US20210121875A1 (en) | Peristaltic pumping of fluids for bioanalytical applications and associated methods, systems, and devices | |
| CN1316040C (en) | Device and method for accelerating biological chip micro fluid reaction | |
| CN107643273B (en) | Aggregation-induced emission biosensor based on hollow photonic crystal fiber | |
| JP2004283083A (en) | On-line chemical reaction unit and analysis system therefor | |
| JP2005318834A (en) | On-line chemical reaction device | |
| CN212008321U (en) | Integrated multifunctional rapid detection equipment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A SPR-based drug screening device Effective date of registration: 20220901 Granted publication date: 20210810 Pledgee: Bank of Communications Co.,Ltd. Shanghai Jing'an Sub branch Pledgor: SHANGHAI TAOSHU BIOTECHNOLOGY CO.,LTD. Registration number: Y2022310000227 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231122 Granted publication date: 20210810 Pledgee: Bank of Communications Co.,Ltd. Shanghai Jing'an Sub branch Pledgor: SHANGHAI TAOSHU BIOTECHNOLOGY CO.,LTD. Registration number: Y2022310000227 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A SPR based drug screening device Effective date of registration: 20231221 Granted publication date: 20210810 Pledgee: Bank of Communications Co.,Ltd. Shanghai Jing'an Sub branch Pledgor: SHANGHAI TAOSHU BIOTECHNOLOGY CO.,LTD. Registration number: Y2023310000902 |