CN109877120A - Sleeve needle suitable for magnetic bead cleaning system - Google Patents

Sleeve needle suitable for magnetic bead cleaning system Download PDF

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Publication number
CN109877120A
CN109877120A CN201910284187.5A CN201910284187A CN109877120A CN 109877120 A CN109877120 A CN 109877120A CN 201910284187 A CN201910284187 A CN 201910284187A CN 109877120 A CN109877120 A CN 109877120A
Authority
CN
China
Prior art keywords
needle
cleaning
interior
magnetic bead
pipe joint
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201910284187.5A
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Chinese (zh)
Inventor
王超
刘桐瑞
赵鹏
潘洋
吴江
刘海鹰
刘聪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autobio Labtec Instruments Zhengzhou Co Ltd
Original Assignee
Autobio Labtec Instruments Zhengzhou Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autobio Labtec Instruments Zhengzhou Co Ltd filed Critical Autobio Labtec Instruments Zhengzhou Co Ltd
Priority to CN201910284187.5A priority Critical patent/CN109877120A/en
Publication of CN109877120A publication Critical patent/CN109877120A/en
Withdrawn legal-status Critical Current

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Abstract

The invention discloses a kind of sleeve needles suitable for magnetic bead cleaning system, including attachment base, outwardly extending outer cleaning needle is fitted in the mounting groove of the attachment base, interior aspirating needle is connected with by fixation kit in the outer cleaning needle, the outer end of the interior aspirating needle extend outwardly out cleaning needle outer end formed inserting paragraph, the inner end of interior aspirating needle is pierced by outer cleaning needle inner end and is connected on the bottom wall of the mounting groove;It is provided with the outer pipe joint being connected to outer cleaning needle on the attachment base or outer cleaning needle, the interior pipe joint being connected to interior aspirating needle is provided on attachment base or outer cleaning needle.The invention has the advantages that structure is simple, sleeve needle has self-cleaning function, can guarantee that interior aspirating needle inner and outer wall cleans up, and cleaning effect is good, prevent from cross contamination occur between different samples and the accuracy and reliability that influences pattern detection result.

Description

Sleeve needle suitable for magnetic bead cleaning system
Technical field
The present invention relates to the magnetic bead cleaning system of in-vitro diagnosis equipment, more particularly, to a kind of suitable for magnetic bead cleaning system Sleeve needle.
Background technique
Existing in-vitro diagnosis equipment (such as chemical illumination immunity analysis instrument, Biochemical Analyzer and nucleic acid instrument) utilizes chemistry more Or instruction system of the bio-luminescence system as antigen-antibody reaction, so as to quantitative detection antigen or antibody.Isolating and purifying sample The specific antibody or receptor (i.e. target body) in magnetic bead absorption sample are usually utilized when product, utilize magnetic bead cleaning system after the reaction was completed The aspirating needle of system will not participate in reaction sample impurity in sample is sucked out, then by the injection needle of magnetic bead cleaning system to reaction cup Remaining sample impurity on interior injection cleaning solution cleaning magnetic bead.
Patent of invention CN103599898A discloses a kind of Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device, magnetic The cleaning needle of multiple aspirating needles and multiple cleaning magnetic beads is provided on the lifting punch block of pearl cleaning device, aspirating needle and cleaning needle are handed over For arrangement, aspirating needle is single-cylinder type structure, i.e. aspirating needle only has a needle tubing, by aspirating needle sample drawn waste liquid and is discarded clear Washing lotion injects cleaning solution into reaction cup by cleaning needle.But due to the sample waste liquid viscosity after target antibody and magnetic bead absorption Greatly, it is particularly easy to be attached on the outer wall of aspirating needle in imbibition process, aspirating needle outer wall washing difficulty is big, and then causes not same There is cross contamination between this, influence the accuracy of testing result, repeatability is poor.
Summary of the invention
It is an object of that present invention to provide a kind of sleeve needles suitable for magnetic bead cleaning system, have self-cleaning function, cleaning effect Fruit is good, avoids cross contamination occur between different samples completely.
To achieve the above object, the present invention takes following technical proposals:
Sleeve needle of the present invention suitable for magnetic bead cleaning system, including attachment base are fitted in the mounting groove of the attachment base Outwardly extending outer cleaning needle is connected with interior aspirating needle by fixation kit in the outer cleaning needle, the interior aspirating needle outside The cleaning needle outer end out that extends outwardly is held to form inserting paragraph, the inner end of interior aspirating needle is pierced by outer cleaning needle inner end and is connected in the peace On the bottom wall of tankage;Be provided with the outer pipe joint being connected to outer cleaning needle on the attachment base or outer cleaning needle, attachment base or The interior pipe joint being connected to interior aspirating needle is provided on outer cleaning needle.
The attachment base is the T-shaped structure being made of fixing seat and cross bar, opens up the mounting groove on the cross bar Extend along cross bar length direction.
Said inner tube pipeline connector is worn on the fixing seat along longitudinal direction, and the outer pipe joint is vertically set on described outer On cleaning needle.
The outer flushing channel being connected to the mounting groove is offered in the fixing seat of the interior aspirating needle side.
The interior aspirating needle inner end is pierced by the cross bar outward and forms construction section, and said inner tube pipeline connector is sleeved on the peace It fills in section;The outer pipe joint setting is connected on the fixing seat and with the outer flushing channel.
The outer pipe joint setting is connected on the fixing seat and with the outer flushing channel, and said inner tube road connects Head is threaded through in fixing seat or is vertically set on the outer cleaning needle.
The attachment base is horizontally disposed mounting base, and the outer pipe joint is vertically set on the outer cleaning needle, Said inner tube pipeline connector is sleeved on the interior aspirating needle for extending the mounting base or is vertically set on the outer cleaning needle.
The section structure of the outer cleaning needle and interior aspirating needle is circular configuration, ellipsoidal structure, equilateral triangle structure Or regular polygon structure.
The fixation kit is the fixing groove being recessed by the outer cleaning needle needle wall or is by the interior aspirating needle needle The fixing lug boss that wall evagination is formed, or the positioning column to be installed between interior aspirating needle and outer cleaning needle.
The fixation kit is the fixed ring being sleeved on the interior aspirating needle, is arranged at intervals with and holds out against in the fixed ring Structure;The fixed ring is close to the outer cleaning needle inner wall, and the top tight structure is molding first locating slot of indent, and described the The inner wall of a positioning groove is close to the outer wall of the interior aspirating needle;Or the fixed ring is close to interior cleaning needle outer wall, top tight structure is The outer wall of the second locating slot outwardly protruded, second locating slot is close to outer cleaning needle;Or the fixed ring and interior aspirating needle, Outer cleaning needle gap setting, top tight structure are fixed column.
Said inner tube pipeline connector is rectilinear structure or L-shaped structure;The outer pipe joint is rectilinear structure or L shape knot Structure.
The invention has the advantages that structure is simple, this sleeve needle has self-cleaning function, can guarantee interior aspirating needle inner wall and Outer wall washing is clean, and cleaning effect is good, prevents from occurring cross contamination between different samples and influencing the accurate of pattern detection result Property and reliability.Specifically, in sample drawn waste liquid, only in aspirating needle inserting paragraph insertion sample waste liquid in, when cleaning to Cleaning solution is injected in outer cleaning needle, cleaning solution constantly rinses the outer wall of interior aspirating needle, it is ensured that interior aspirating needle outer wall washing effect is led to Cross interior pipe joint inside aspirating needle injection cleaning solution, realize in aspirating needle inner wall continuous wash, interior aspirating needle inner wall and outer Wall cleaning effect is good, can avoid occurring cross contamination between different samples completely, improves the accuracy rate of pattern detection result.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention.
Fig. 2 is the schematic cross-sectional view of Fig. 1.
Fig. 3 .1 is the first structural schematic diagram of fixation kit of the present invention.
Fig. 3 .2 is second of structural schematic diagram of fixation kit of the present invention.
Fig. 3 .3 is the third structural schematic diagram of fixation kit of the present invention.
Fig. 3 .4 is the 4th kind of structural schematic diagram of fixation kit of the present invention.
Fig. 3 .5 is the 5th kind of structural schematic diagram of fixation kit of the present invention.
Fig. 3 .6 is the 5th kind of structural schematic diagram of fixation kit of the present invention.
Fig. 4 is another structural schematic diagram of the invention.
Fig. 5 is the third structural schematic diagram of the invention.
Fig. 6 is the 4th kind of structural schematic diagram of the invention.
Fig. 7 is the 5th kind of structural schematic diagram of the invention.
Fig. 8 is the 6th kind of structural schematic diagram of the invention.
Fig. 9 is the 7th kind of structural schematic diagram of the invention.
Figure 10 is the 8th kind of structural schematic diagram of the invention.
Figure 11 is the 9th kind of structural schematic diagram of the invention.
Specific embodiment
As shown in Figure 1, 2, the sleeve needle of the present invention suitable for magnetic bead cleaning system, including attachment base, the attachment base For the T-shaped structure being made of fixing seat 6.1 and cross bar 6.2, the mounting groove 1 being laterally extended is offered on the cross bar 6.2, it is described It is fitted with outwardly extending outer cleaning needle 2 in mounting groove 1, interior aspirating needle 3, the interior imbibition are provided in the outer cleaning needle 2 The outer end of needle 3 extend outwardly out 2 outer end of cleaning needle formed inserting paragraph 3.1, for guarantee in aspirating needle 3 and outer cleaning needle 2 company Stability is connect, is provided with fixation kit on the outer cleaning needle 2 or interior aspirating needle 3 close to the inserting paragraph 3.1,
As shown in Fig. 3 .1, fixation kit is the fixing groove 9 being recessed by the outer 2 needle wall of cleaning needle, and fixing groove 9 is three It can also be four, five or more, three fixing grooves 9 are set along outer 2 needle wall circumferential direction ring of cleaning needle;Certainly when practical manufacture, Gu Determining component can also be that the fixing lug boss 10 formed by the interior 3 needle wall evagination of aspirating needle, fixing lug boss 10 are spaced It is three, specific as shown in Figure 3 .2;Certain fixation kit can also be the positioning fixed between interior aspirating needle 3 and outer cleaning needle 2 Column 11, positioning column 11 is three, specifically as shown in Fig. 3 .3;Certain fixation kit can also be to be sleeved on the interior aspirating needle 3 Fixed ring 12, be arranged at intervals with top tight structure in the fixed ring 12, wherein fixed ring 12 is close in the outer cleaning needle 2 Wall, the top tight structure are molding first locating slot 13 of indent, and the inner wall of first locating slot 13 is close to the interior imbibition The outer wall of needle 3, specifically as shown in Fig. 3 .4;Or fixed ring be close in cleaning needle 3 outer wall, top tight structure is the outwardly protruded Two locating slots 14, the outer wall of second locating slot 14 is close to outer cleaning needle 2, specifically as shown in Fig. 3 .5;Alternatively, fixed ring with Interior aspirating needle 3,2 gap setting of outer cleaning needle, top tight structure is fixed column 15, specifically as shown in Fig. 3 .6.
The inner end of the interior aspirating needle 3, which is pierced by outer 2 inner end of cleaning needle and is pierced by the cross bar 6.2 outward, forms construction section, Interior pipe joint 5 is set on the construction section;Offered in the fixing seat 6.1 of 3 upside of interior aspirating needle with The outer flushing channel 7 that the mounting groove 1 is connected to, 6.1 upper end of fixing seat is vertically installed with the outer pipeline being connected to outer flushing channel 7 Connector 4, interior pipe joint 5 and outer pipe joint 4 be rectilinear structure according to actual needs, interior pipe joint 5 and outer pipeline L-shaped structure can also be made in connector 4, certain outer pipe joint 4 can also be inserted into along longitudinal direction in fixing seat 6.1 and with outer cleaning Channel 7 is connected to, specific as shown in Figure 4;
When practical manufacture, interior pipe joint 5 and outer pipe joint 4 can also use following mounting means, as shown in figure 5, interior suction 3 inner end of liquid needle is extended outer 2 inner end of cleaning needle and is connected on the bottom wall of mounting groove 1, outer pipe joint 4 by fixing seat 6.1 top Portion pierces into downwards fixing seat 6.1 and is connected to outer flushing channel 7, and fixing seat is pierced into interior 5 self-retaining seat of pipe joint, 6.1 bottom upwards 6.1 are connected to interior aspirating needle 3;As shown in fig. 6, outer 2 inner end of cleaning needle is extended in interior 3 inner end of aspirating needle is connected in mounting groove 1 On bottom wall, outer pipe joint 4 pierces into downwards fixing seat 6.1 by the top of fixing seat 6.1 and is connected to outer flushing channel 7, interior pipeline Connector 5 is vertically connected on outer cleaning needle 2;As shown in fig. 7, outer 2 inner end of cleaning needle is extended in interior 3 inner end of aspirating needle is connected in peace On the bottom wall of tankage 1, outer pipe joint 4 is vertically set in fixing seat 6.1 to be connected to outer flushing channel 7, and interior pipe joint 5 hangs down It is directly connected on outer cleaning needle 2;As shown in figure 8, outer 2 inner end of cleaning needle is extended in interior 3 inner end of aspirating needle is connected in mounting groove 1 On bottom wall, outer pipe joint 4 is vertically set in fixing seat 6.1 to be connected to outer flushing channel 7, interior 5 self-retaining seat of pipe joint 6.1 bottoms are pierced into fixing seat 6.1 upwards and are connected to interior aspirating needle 3;As shown in figure 9, outer cleaning needle is extended in interior 3 inner end of aspirating needle 2 inner ends are connected on the bottom wall of mounting groove 1, and fixing seat 6.1 and interior suction are pierced into interior 5 self-retaining seat of pipe joint, 6.1 bottom upwards Liquid needle 3 is connected to, and outer pipe joint 4 is vertically arranged in outer cleaning needle 2 and is connected to outer cleaning needle 2;As shown in Figure 10, attachment base is Horizontally disposed mounting base 8, the outer pipe joint 4 are vertically set on the outer cleaning needle 2, and 5 sets of said inner tube pipeline connector On the interior aspirating needle 3 for extending the mounting base 8;As shown in figure 11, attachment base is horizontally disposed mounting base 8, interior suction 3 inner end of liquid needle is extended outer 2 inner end of cleaning needle and is connected on the bottom wall of mounting groove 1, and interior pipe joint 5 and outer pipe joint 4 are equal It is vertically arranged on outer cleaning needle 2.
When practical manufacture, for the cleaning effect for guaranteeing interior aspirating needle 3, the section of interior aspirating needle 3 and outer cleaning needle 2 is circle Shape structure or ellipsoidal structure.
In use, interior pipe joint 5 is connected to waste-solution line and detergent line, outer pipe joint 4 is connected to detergent line, Sleeve needle of the present invention is fixed on the lifting punch block of magnetic bead cleaning system, when sample drawn waste liquid, sleeve needle decline It is located at the lower end of the inside and outside cleaning needle 2 of sample waste liquid in the 3.1 intercalation reaction cup of inserting paragraph of interior aspirating needle 3 above sample, gives up Sample is pumped in specified containers by the drawing liquid pump work on liquid pipeline;Specified containers, cleaning pipe are drained into completely to sample waste liquid Cleaning solution is injected separately into the inner and outer cleaning needle 2 of interior aspirating needle 3 by the cleaning pump movement of road, and interior 3 length of aspirating needle is longer than Outer cleaning needle 2, the cleaning solution in outer cleaning needle 2 wash away interior aspirating needle 3 by its outlet outflow, guarantee in 3 outer wall of aspirating needle it is clear Effect is washed, the cleaning needle in interior aspirating needle 3 is clean by interior 3 inner wall washing of aspirating needle during flowing downward, sleeve needle cleaning effect Fruit is good, and different samples is avoided cross contamination occur completely, improves the accuracy of testing result.
In the description of the present invention, it should be noted that the side of the instructions such as term " vertical ", "horizontal", "inner", "outside" Position or positional relationship are to be based on the orientation or positional relationship shown in the drawings, and are merely for convenience of description of the present invention and simplification of the description, Rather than the device or element of indication or suggestion meaning must have a particular orientation, be constructed and operated in a specific orientation, because This is not considered as limiting the invention.

Claims (11)

1. a kind of sleeve needle suitable for magnetic bead cleaning system, it is characterised in that: including attachment base, the mounting groove of the attachment base (1) outwardly extending outer cleaning needle (2) is fitted in, the outer cleaning needle (2) is interior to be connected with interior aspirating needle by fixation kit (3), the outer end of the interior aspirating needle (3) extend outwardly out cleaning needle (2) outer end formed inserting paragraph (3.1), interior aspirating needle (3) Inner end be pierced by outer cleaning needle (2) inner end and be connected on the bottom wall of the mounting groove (1);The attachment base or outer cleaning needle (2) On be provided with the outer pipe joint (4) being connected to outer cleaning needle (2), be provided with and interior imbibition on attachment base or outer cleaning needle (2) The interior pipe joint (5) of needle (3) connection.
2. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 1, it is characterised in that: the attachment base is by fixing The T-shaped structure that seat (6.1) and cross bar (6.2) are constituted, is provided with the mounting groove (1) on the cross bar (6.2) along cross bar (6.2) length direction extends.
3. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 2, it is characterised in that: said inner tube pipeline connector (5) It is threaded through on the fixing seat (6.1) along longitudinal direction, the outer pipe joint (4) is vertically set on the outer cleaning needle (2).
4. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 2, it is characterised in that: be located at the interior aspirating needle (3) the outer flushing channel (7) being connected to the mounting groove (1) is offered in the fixing seat (6.1) of side.
5. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 4, it is characterised in that: in the interior aspirating needle (3) End is pierced by the cross bar (6.2) outward and forms construction section, and said inner tube pipeline connector (5) is sleeved on the construction section;It is described outer Pipe joint (4) is arranged on the fixing seat (6.1) and is connected to the outer flushing channel (7).
6. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 4, it is characterised in that: the outer pipe joint (4) It is arranged on the fixing seat (6.1) and is connected to the outer flushing channel (7), said inner tube pipeline connector (5) is threaded through fixation On seat (6.1) or it is vertically set on the outer cleaning needle (2).
7. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 1, it is characterised in that: the attachment base sets for level The mounting base (8) set, the outer pipe joint (4) are vertically set on the outer cleaning needle (2), said inner tube pipeline connector (5) It is sleeved on the interior aspirating needle (3) for extending the mounting base (8) or is vertically set on the outer cleaning needle (2).
8. according to claim 1 be suitable for magnetic bead cleaning system sleeve needle, it is characterised in that: the outer cleaning needle (2) and The section structure of interior aspirating needle (3) is circular configuration, ellipsoidal structure, equilateral triangle structure or regular polygon structure.
9. according to right want 1 described in be suitable for magnetic bead cleaning system sleeve needle, it is characterised in that: the fixation kit be by described The fixing groove (9) that outer cleaning needle (2) needle wall is recessed or the fixing lug boss to be formed by interior aspirating needle (3) the needle wall evagination (10), or to be installed on the positioning column (11) between interior aspirating needle (3) and outer cleaning needle (2).
10. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 1, it is characterised in that: the fixation kit is set Fixed ring (12) on the interior aspirating needle (3) is arranged at intervals with top tight structure on the fixed ring (12);The fixation Ring is close to outer cleaning needle (2) inner wall, and the top tight structure is molding first locating slot (13) of indent, first positioning The inner wall of slot (13) is close to the outer wall of the interior aspirating needle (3);Or the fixed ring is close to interior cleaning needle (3) outer wall, holds out against knot Structure is the second locating slot (14) outwardly protruded, and the outer wall of second locating slot (14) is close to outer cleaning needle (2);Or it is described solid Determine ring (12) and interior aspirating needle (3), outer cleaning needle (2) gap setting, top tight structure is the fixation being arranged on fixed ring (12) Column (15).
11. being suitable for the sleeve needle of magnetic bead cleaning system according to claim 1, it is characterised in that: said inner tube pipeline connector (5) For rectilinear structure or L-shaped structure;The outer pipe joint (4) is rectilinear structure or L-shaped structure.
CN201910284187.5A 2019-04-10 2019-04-10 Sleeve needle suitable for magnetic bead cleaning system Withdrawn CN109877120A (en)

Priority Applications (1)

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CN201910284187.5A CN109877120A (en) 2019-04-10 2019-04-10 Sleeve needle suitable for magnetic bead cleaning system

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112705503A (en) * 2019-10-25 2021-04-27 深圳华大智造科技有限公司 Cleaning assembly, introducing device and fluid system
CN114774240A (en) * 2022-06-22 2022-07-22 至美时代生物智能科技(北京)有限公司 Nucleic acid adsorption set, automatic magnetic needle sleeve set device and automatic discarding device
CN115932310A (en) * 2022-12-27 2023-04-07 山东中鸿特检生物科技有限公司 Detachable sample site and chemiluminescence immunoassay device

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CN106546758A (en) * 2016-09-28 2017-03-29 长春迪瑞医疗科技股份有限公司 A kind of Full-automatic chemiluminescence immunoassay analysis meter and its liquid-way system
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CN108856181A (en) * 2018-04-28 2018-11-23 深圳市亚辉龙生物科技股份有限公司 The cleaning equipment of Magneto separate aspirating needle clean method and application this method
CN109201653A (en) * 2018-09-26 2019-01-15 苏州长光华医生物医学工程有限公司 A kind of sample needle cleaning device
CN109500017A (en) * 2018-12-08 2019-03-22 安图实验仪器(郑州)有限公司 Hair washing component for in-vitro diagnosis equipment
CN209715942U (en) * 2019-04-10 2019-12-03 安图实验仪器(郑州)有限公司 Sleeve needle suitable for magnetic bead cleaning system

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Publication number Priority date Publication date Assignee Title
JP2007309938A (en) * 2006-05-17 2007-11-29 Amr Inc Needle unit for sample injection, and sample suction/cleaning device of syringe using the same
WO2008140707A1 (en) * 2007-05-11 2008-11-20 Bio-Rad Laboratories, Inc. Wash ring assembly and method of use
CN203265144U (en) * 2013-04-23 2013-11-06 上海裕隆生物科技有限公司 Washing device
CN103599898A (en) * 2013-10-29 2014-02-26 北京利德曼生化股份有限公司 Full-automatic chemiluminescence immune analyzer magnetic bead washing device
CN106546758A (en) * 2016-09-28 2017-03-29 长春迪瑞医疗科技股份有限公司 A kind of Full-automatic chemiluminescence immunoassay analysis meter and its liquid-way system
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112705503A (en) * 2019-10-25 2021-04-27 深圳华大智造科技有限公司 Cleaning assembly, introducing device and fluid system
CN114774240A (en) * 2022-06-22 2022-07-22 至美时代生物智能科技(北京)有限公司 Nucleic acid adsorption set, automatic magnetic needle sleeve set device and automatic discarding device
CN115932310A (en) * 2022-12-27 2023-04-07 山东中鸿特检生物科技有限公司 Detachable sample site and chemiluminescence immunoassay device
CN115932310B (en) * 2022-12-27 2023-08-18 山东中鸿特检生物科技有限公司 Detachable sample position and chemiluminescent immunoassay device

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