CN109847167B - Local anesthesia slow-release drug coating stent and conveying application system - Google Patents

Abstract

The invention relates to the field of medical appliances, in particular to a local anesthesia slow-release drug coating stent and a conveying application system; the device comprises a film coating layer and a conduit mechanism for conveying the film coating layer into a tube cavity and clinging to a stent; a drug application layer for attaching a solid slow-release anesthetic and a particle bin layer for loading radioactive particles are uniformly distributed on the film coating layer; the catheter mechanism comprises a first sleeve, a second sleeve and a third sleeve, a guide wire penetrates through the third sleeve, and the laminating layer is sleeved in the first sleeve and is positioned between the second sleeve and the third sleeve; in the invention, the second sleeve and the third sleeve in the catheter mechanism are extended to pull the film coating layer sleeved between the second sleeve and the third sleeve to be attached to the stent, the slow-release anesthetic on the drug application layer on the film coating layer is used for anesthesia, and the radiation particles in the particle bin layer are used for radiotherapy without taking out the original stent and replacing the iodine particle stent, thereby avoiding secondary damage.

Description

Local anesthesia slow-release drug coating stent and conveying application system

Technical Field

The invention relates to the field of medical instruments, in particular to a local anesthesia slow-release drug coating stent and a delivery and application system.

Background

Over-range surgical resection remains the only radical treatment for luminal tumors (luminal, biliary, intestinal, tracheal, intravascular emboli, ureteral, etc.). However, local infiltration and metastasis of distant organs have already occurred in most patients during treatment. For such patients, improving quality of life and prolonging survival have become major therapeutic targets. For example, a metal stent is implanted in a cavity to open a narrow lumen to palliatively relieve clinical symptoms of a patient, and the implanted metal stent often needs to exceed two ends of a tumor tissue by at least 2 cm. The physical expansion of the stent squeezes the tumor tissue to the outside of the vessel wall. The continuous expansion of the metal stent causes local discomfort symptoms to some patients, for example, the tracheal stent causes the patients to have continuous cough, especially cannot sleep at night, and seriously affects the life quality. The high-position lumen stent causes severe foreign body sensation to the patient, the intestinal stent causes severe abdominal pain to the patient, and the ureteral stent causes severe discomfort to the lumbosacral part of the patient. The use of local anesthetic drugs (such as bupivacaine/lidocaine) can significantly reduce the local discomfort of the patient and improve the quality of life. The modern film coating drug loading technology is adopted, such as PGLA, a nano coating, graphene and the like are used as carriers, after a metal stent is released from an outer membrane of a local drug-loaded stent, symptoms such as related discomfort and the like caused by tumor compression due to stent implantation are reduced through slow release of local anesthetic, and as the drug is released in a local continuous low dose, related complications such as drug accumulation and the like are not caused, so that the method is worthy of further clinical popularization.

In addition, liver cancer is also a common malignant tumor in clinic, and patients with liver cancer often invade portal vein to form portal vein cancer embolus, so that the disease progresses rapidly, and the long-term survival is extremely poor. Therefore, the treatment of the portal vein cancer suppository has a decisive significance for the long-term survival of the liver cancer patients. External radiotherapy is often adopted clinically to treat portal vein cancer embolus, but because the spread range of the cancer embolus is wide, and the cancer embolus is distributed along a curved blood vessel system, positioning radiotherapy is difficult, and because respiratory movement causes the liver of a patient to move, the irradiation range of the external radiotherapy needs to be expanded in order to cover the tumor range, and then the liver is greatly damaged. Clinical palliative treatment schemes mainly open the portal vein lumen to restore hepatic blood flow, thereby improving the quality of life of patients. The minimally invasive puncture technology is needed to be adopted, the portal vein stent is implanted to open the blood vessel, but the stent can only open the lumen, has no treatment effect on the tumor, and more than 50 percent of patients can be blocked in the stent within 3 months along with the development of the tumor. Therefore, domestic scholars adopt close-range radioactive particles to form a chain structure, and use an interventional technique to press 125I particle chains outside the stent, and partial cancer embolisms are controlled through close-range radiotherapy of the particles, so that the unobstructed time of the stent is prolonged. However, due to the randomness of the implanted chains, the brachytherapy is failed due to the fact that the implanted chains are implanted into the non-tumor once. Moreover, clinical studies have shown that the use of chains of particles only extends patency for 2-3 months. The reason for the analysis is as follows: the number of particles is small, resulting in excessive dose cooling; the particle chain is positioned on the opposite side of the tumor tissue, and after the stent is expanded, the particles are farther away from the tumor, so that a better anti-tumor effect cannot be exerted. Therefore, there is a need to develop a complete set of helical 125I particle implantation system, which can solve the problem of non-uniform dose distribution and reduce the dose cooling zone. On one hand, the tumor can be fully contacted with the particles, and the curative effect of brachytherapy is improved.

Disclosure of Invention

In order to solve the above problems, an object of the present invention is to provide a local anesthesia sustained-release drug-coated stent and a delivery application system, wherein a coating layer covering a catheter mechanism is pulled apart and attached to a stent by extending a second sleeve and a third sleeve in the catheter mechanism, and a sustained-release anesthetic is applied to the drug-coated layer on the coating layer to perform anesthesia and radiotherapy on radioactive particles in a particle chamber, without taking out the original stent and replacing an iodine 125 particle stent, thereby avoiding secondary damage.

The purpose of the invention is realized by the following technical scheme:

the invention provides a local anesthesia slow-release drug coating stent and a conveying and applying system, wherein the local anesthesia slow-release drug coating stent comprises a film coating layer and a catheter mechanism, wherein the film coating layer is used for clinging to the stent, and the catheter mechanism is used for conveying the film coating layer into a tube cavity and clinging to the stent; a drug application layer for attaching a solid slow-release anesthetic and a particle bin layer for loading radioactive particles are uniformly distributed on the film coating layer; the catheter mechanism comprises a first sleeve, a second sleeve sleeved in the first sleeve and a third sleeve sleeved in the second sleeve, a guide wire penetrates through the third sleeve, the laminating layer is sleeved in the first sleeve and located between the second sleeve and the third sleeve, and the third sleeve is pulled open and pasted on the support after extending out of the second sleeve.

As an improvement of the invention, a furling cavity is arranged in the first sleeve, the outer wall of the lower end of the second sleeve is connected with an upper layer balloon, the outer wall of the lower end of the third sleeve is connected with a lower layer balloon, and the furling cavity can furl the upper layer balloon and the lower layer balloon; a first air passage is arranged in the first sleeve, a first inflation pipe is arranged in the first air passage, and the upper layer balloon is communicated with a first inflation one-way valve joint through the first inflation pipe; and a second air passage is arranged in the third sleeve, a second inflation tube is arranged in the second air passage, and the lower layer balloon is communicated with the second inflation check valve joint through the second inflation tube.

As a further improvement of the invention, the upper layer balloon and the lower layer balloon are both provided with two balloon cavities.

As a further improvement of the invention, the upper end and the lower end of the film coating layer are provided with clamping rings, and the clamping rings are provided with bracket clamping grooves for clamping on the bracket.

As a further improvement of the invention, two slow-release anesthetic cavities for storing slow-release anesthetic are arranged on the clamping ring, and the slow-release anesthetic cavities are provided with clamping ring permeation holes.

As a further improvement of the invention, the two slow-release anesthetic cavities are communicated through a communicating groove.

As a further improvement of the invention, the collar is provided with an inclined surface, and the outer rings of the upper layer balloon and the lower layer balloon are provided with abdicating groove surfaces matched with the inclined surface.

As a further improvement of the invention, a plurality of film-covered permeation holes are arranged on the drug application layer.

As a further improvement of the present invention, a spiral furling tube is arranged in the first sleeve, a conduit head is arranged at the lower end of the third sleeve, a tightening sleeve is coaxially connected to the conduit head, a clamping support is sleeved between the second sleeve and the tightening sleeve, the spiral furling tube can sleeve the clamping support, and the film coating layer is sleeved between the clamping support and the spiral furling tube.

As a further improvement of the invention, the first sleeve, the second sleeve and the third sleeve are provided with handle ends.

In the invention, the second sleeve and the third sleeve in the catheter mechanism are extended to pull the coated layer sleeved between the second sleeve and the third sleeve to be attached to the stent, the slow-release anesthetic on the drug application layer on the coated layer is utilized to perform anesthesia and the radiation particles in the particle bin layer are used for performing radiotherapy, the original stent does not need to be taken out and the iodine particle stent does not need to be replaced, and secondary damage is not caused.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without limiting the invention. In the drawings:

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a front view of the present invention;

FIG. 3 is a first schematic view of a close contact structure between a film layer and a stent according to the present invention;

FIG. 4 is a schematic view of a second adhesion structure of the film layer and the stent of the present invention;

FIG. 5 is a first schematic view of a structure of a coating layer according to the invention;

FIG. 6 is a first schematic view of the structure of the retainer ring of the present invention;

FIG. 7 is a second schematic view of the structure of the retainer ring of the present invention;

FIG. 8 is a second schematic view of a structure of a coating layer according to the present invention;

FIG. 9 is a third schematic structural view of a coating layer according to the present invention;

FIG. 10 is a first schematic view of the internal structure of the catheter mechanism of the present invention;

FIG. 11 is a second schematic view of the internal structure of the catheter mechanism of the present invention;

FIG. 12 is a third schematic view of the internal structure of the catheter mechanism of the present invention;

FIG. 13 is a fourth schematic view of the internal structure of the catheter mechanism of the present invention;

FIG. 14 is a fifth schematic view of the internal structure of the catheter mechanism of the present invention;

FIG. 15 is a schematic view of the connection structure of the upper balloon and the collar of the present invention;

FIG. 16 is a first schematic structural diagram according to a first embodiment of the present invention;

FIG. 17 is a second schematic structural diagram according to a first embodiment of the present invention;

FIG. 18 is a first expanded view of the first embodiment of the present invention;

FIG. 19 is a second expanded view of the first embodiment of the present invention;

FIG. 20 is a schematic view of the connection structure of the clamping bracket and the bracket of the present invention;

FIG. 21 is a first view illustrating the connection structure of the clamping bracket according to the present invention;

FIG. 22 is a second view of the connection structure of the clamping bracket of the present invention;

FIG. 23 is a first schematic view of the structure of a clamping bracket, a film coating layer and a bracket of the clamping bracket of the invention;

FIG. 24 is a second schematic structural view of a clamping stent, a coating layer and a stent of the clamping stent of the present invention;

FIG. 25 is an exploded view of the attachment structure of the clamping bracket, the coating layer and the bracket of the clamping bracket of the present invention;

FIG. 26 is a first structural view of the spirally gathered tube of the present invention;

FIG. 27 is a second structural view of the spirally gathered tube of the present invention;

fig. 28 is a schematic view of the inside of the spirally gathered tube of the present invention.

Wherein the reference numerals are: 1-a film covering layer, 11-a medicine application layer, 111-a film covering permeation hole, 12-a particle bin layer, 13-a collar, 131-a stent clamping groove, 132-a slow-release anesthetic cavity, 133-a communication groove, 134-a slope, 135-a collar permeation hole, 2-a catheter mechanism, 21-a first sleeve, 211-a furling cavity, 212-a first air passage, 213-a first inflation tube, 214-a first inflation one-way valve joint, 215-a second air passage, 216-a second inflation tube, 217-a second inflation one-way valve joint, 218-a spiral furling tube, 22-a second sleeve, 221-an upper balloon, 222-a balloon cavity, 223-a abdicating groove surface, 23-a third sleeve, 231-a lower balloon, 24-a guide wire, 25-a handle end and 3-a stent.

Detailed Description

In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in fig. 1 to fig. 28, the local anesthesia slow-release drug-coated stent and delivery application system of the present invention comprises a coating layer 1 for clinging to a stent 3 and a catheter mechanism 2 for delivering the coating layer 1 into a lumen clinging to the stent 3.

As shown in fig. 5, a drug application layer 11 for attaching a solid sustained-release anesthetic and a particle bin layer 12 for loading radioactive particles are uniformly distributed on the coating layer 1.

The catheter mechanism 2 comprises a first sleeve 21, a second sleeve 22 sleeved in the first sleeve 21 and a third sleeve 23 sleeved in the second sleeve 22, a guide wire 24 penetrates through the third sleeve 23, the film coating layer 1 is sleeved in the first sleeve 21 and is located between the second sleeve 22 and the third sleeve 23, and the third sleeve 23 stretches out of the second sleeve 22 and then pulls the film coating layer 1 open to be attached to the support 3.

In the invention, the second sleeve 22 and the third sleeve 23 in the catheter mechanism 2 are extended to pull the coating layer 1 sleeved between the two sleeves to be attached to the stent 3, the slow-release anesthetic on the drug application layer 11 on the coating layer 1 is utilized to perform anesthesia, and the radioactive particles in the particle bin layer 12 are used for radiotherapy, so that the original stent does not need to be taken out and the iodine 125 particle stent does not need to be replaced, and secondary damage is avoided.

The support 3 plays a role in a channel for existing on the inner wall of a lumen of a patient, the structure of the support 3 is woven, and the woven wire mesh of the support 3 is made of a nickel-titanium alloy material. The length and the circumference of the bracket 3 are matched with a film coating layer 1, the film coating layer 1 is cylindrical and can be tightly attached to the inner side of the bracket 3 when being opened, and the film coating layer 1 is made of polymer flexible materials. The drug application layer 11 and the particle bin layer 12 are arranged on the film coating layer 1 with meshes of the bracket 3 at intervals on the circumference. The drug application layer 11 and the particle bin layer 12 are uniformly distributed on the film covering of the meshes of the bracket 3 along a plurality of circumferential spirals in the axial direction of the outer wall of the bracket. The strip-shaped iodine 125 particles are loaded in the particle chamber layer 12, the solid slow-release anesthetic is attached in the medicine application layer 11, and the slow-release anesthetic is in a round cake shape, so that the surface of the slow-release anesthetic can be attached to the wall of a patient lumen to the maximum extent for anesthesia. The particle bin layer 12 is spirally and uniformly distributed at the meshes of the stent 3 by adopting a single spiral, and the design can ensure that the drug covered with the stent and the iodine 125 particles can be circumferentially and integrally used for radiotherapy and drug-assisted treatment of the tumor part in the lumen region; and a plurality of film-coated permeation holes 111 are arranged on the outer layer of the drug application layer 11 of the film-coated layer 1, and the film-coated permeation holes 111 are helpful for the permeation of drugs, so that the drug therapy effect on the tumors in the lumen area is more convenient.

As shown in fig. 3, 6 and 7, collars 13 are arranged at the upper and lower ends of the coating layer 1, and bracket clamping grooves 131 for clamping on the bracket 3 are arranged on the collars 13; the retainer ring 13 is provided with two slow-release anesthetic cavities 132 for storing slow-release anesthetic, and the slow-release anesthetic cavities 132 are provided with retainer ring permeation holes 135; the two slow-release anesthetic cavities 132 are communicated through a communicating groove 133; the drug application layer 11 is provided with a plurality of film-coating permeation holes 111; specifically, an annular retainer 13 is connected to the upper and lower end ports of the cylindrical coating layer 1, and the retainer 13 is made of a medical polymer material having elastic deformation characteristics. The ring-shaped bracket clamping groove 131 is arranged on the upper circumference of the corresponding end surface of the clamping ring 13 facing the upper end surface and the lower end surface of the bracket 3, the facing surface circumference of the bracket clamping groove 131 facing the upper end surface and the lower end surface of the bracket 3 is provided with a gap, and the clamping section of the bracket clamping groove 131 exceeds a semicircular area and is matched with the weaving mesh wire of the bracket 3 in thickness, so that the bracket clamping groove 131 can clamp the bracket mesh wire at the upper port and the lower port of the bracket 3, and after the clamping ring 13 at the upper end and the lower end of the film coating layer 1 clamps the upper port and the lower port of the bracket 3, the film coating layer 1 can be tensioned to be tightly attached to the inner side wall of the bracket 3; as shown in fig. 6 and 7, annular cavities are respectively designed at the oblique angles close to the outer side and the upper side of the stent clamping groove 131 inside the collar 13 to be slow-release anesthetic cavities 132, slow-release anesthetics are filled in the slow-release anesthetic cavities 132, a plurality of collar penetration holes 135 are uniformly formed in the circumference of the outer side walls of the two annular slow-release anesthetic cavities 132, and the collar penetration holes 135 can enable the slow-release anesthetics inside to penetrate into the wall of the patient lumen to achieve an anesthetic effect. Be provided with the interval between two slowly-releasing narcotic cavities 135 in rand 13 oblique angle and the lateral wall, and the circumference evenly is provided with a plurality of intercommunication grooves 133 on the spacing face, and the inside liquid slowly-releasing narcotic liquid in two slowly-releasing narcotic cavities 132 of being convenient for can the interpenetration intercommunication, prevents that one of them chamber liquid medicine from drying up and can't carry out the anesthesia to the lumen wall.

As shown in fig. 10 to 14, a furling cavity 211 is arranged in the first sleeve 21, the outer wall of the lower end of the second sleeve 22 is connected with the upper layer balloon 221, the outer wall of the lower end of the third sleeve 23 is connected with the lower layer balloon 231, and the furling cavity 211 can furl the upper layer balloon 221 and the lower layer balloon 231; a first air passage 212 is arranged in the first sleeve 21, a first inflation tube 213 is arranged in the first air passage 212, and the upper layer balloon 221 is communicated with a first inflation one-way valve joint 214 through the first inflation tube 213; a second air passage 215 is arranged in the third sleeve 21, a second inflation tube 216 is arranged in the second air passage 215, and the lower layer balloon 231 is communicated with a second inflation one-way valve joint 217 through the second inflation tube 216; as shown in fig. 10 and 15, the upper balloon 221 and the lower balloon 231 are each provided with two balloon cavities 222; specifically, the outermost layer of the catheter mechanism 2 is a first sleeve 21, a furling cavity 211 with a blind hole of a certain depth is axially and upwardly arranged on the lower end surface of the first sleeve 21, and the upper balloon 221 and the lower balloon 231 are conveniently furled in the furling cavity 211. The outer wall of the end head of the upper end of the first sleeve 21 is fixedly provided with a linear handle end 25, and the handle end 25 is convenient for hand-holding control of push-pull and rotation prevention. The second sleeve 22 is sleeved at the through hole at the axis of the first sleeve 21, the handle end 25 which is the same as the first sleeve 21 is arranged on the outer wall of the end socket at the upper end of the second sleeve 22, the upper layer balloon 221 is arranged on the outer wall at the lower end port of the second sleeve 22, the upper layer balloon 221 is in a round cake shape when inflated, and the spacing layer is arranged at the middle height inside the upper layer balloon 221 to divide the upper layer balloon into two balloon cavities 222 which are a first upper layer balloon cavity and a second upper layer balloon cavity respectively. The purpose of the two cavities formed by the spacer layer is to enable the upper layer balloon 221 to have certain strength in the middle position of the inflated outer ring and not to be easily dented and deformed like other areas of the upper layer balloon 221 after being pressed. The first air passage 212 is axially arranged in the side wall of the first sleeve 21, the lower end of the first air passage 212 is respectively provided with vent holes in a cavity and two cavities of the upper layer balloon, the port of the first air passage 212 at the upper end of the first sleeve 21 is connected with a first inflation tube 213, the end of the first inflation tube 213 is connected with a first inflation check valve connector 214, and two cavities in the upper layer balloon 221 can be inflated synchronously through the first inflation check valve connector 214. The third sleeve 23 is sleeved inside the second sleeve 22, the linear handle end 25 is also arranged on the side wall of the end head at the upper end of the third sleeve 23, the lower balloon 231 is arranged on the outer wall of the end head at the lower end of the third sleeve 23, the structure of the lower balloon 231 is the same as that of the upper balloon 221, the lower balloon 231 is also divided into two cavities through a middle spacing layer, and the outer ring circumference yielding groove surface 223 can be clamped at the inclined surface 134 of the lower clamping ring 13 after the lower balloon 231 is expanded and filled. The furling cavity 211 at the lower end of the first sleeve 21 has a certain length which can sequentially furl and branch the upper layer balloon 221, the related structure of the coating layer 1 and the lower layer balloon 231. A second air passage 215 is axially arranged in the tube wall of the third sleeve 23, a small hole is formed in the tube wall of the two cavities of the lower balloon 231 of the second air passage 215 to serve as a vent hole, and a second inflation tube 216 and a second inflation check valve joint 217 are connected to the upper end of the third sleeve 23 to inflate the lower balloon 231. A guide wire 24 is inserted through the third sleeve 23 at the axial center thereof for guiding the catheter when it is advanced in the body.

In the invention, the collar 13 is provided with an inclined plane 134, and the outer rings of the upper layer balloon 221 and the lower layer balloon 231 are provided with abdication groove surfaces 223 matched with the inclined plane 134; specifically, the inclined surface 134 is provided at an end surface angle where the collar 13 is away from the port of the holder 3, and the outer side is long and the inner side is short so that the inclined surface 134 is inclined outward and inward. The circumference outer circle of the upper layer balloon 221 is designed to be an abdicating groove surface 223 matched with the inclined surface 134 of the clamping ring 13, so that the upper layer balloon 221 can be embedded, expanded and clamped on the clamping ring 13 after being inflated, and the spacing layer of the upper layer balloon 223 is just positioned at the height of the circumference groove surface, so that the clamping ring can be stabilized.

When iodine 125 particle radiotherapy needs to be performed on the stent 3 inside the lumen of a patient, the first sleeve 21, the second sleeve 22, the third sleeve 23 and the guide wire 25 are sequentially sleeved in an initial state, meanwhile, a related structure of the coating layer 1 is filled between the upper layer balloon 221 and the lower layer balloon 231 which are folded in the lower section of the first sleeve 21, the cavity is folded, and the related structure is conveyed to the position of the patient stent 3 by the catheter mechanism 2, and the first sleeve 21 is pulled upwards to expose the lower ends of the second sleeve 22 and the third sleeve 23. The second inflation check valve joint 217 is inflated first, the gas enters the lower balloon 231 through the second air passage 215 in the tube wall of the third sleeve 23 to be inflated, the lower balloon 231 drives the lower clamping ring 13 to be expanded to a circumferential shape, and the stent clamping groove 131 of the clamping ring 13 is clamped at the port of the stent 3. When the lower end of the stent 3 is clamped by the lower retainer ring 13, the upper balloon 221 is inflated and inflated by the same operation and the upper retainer ring 13 is clamped at the port of the upper end of the stent 3, and in the clamping and fixing process of the retainer ring 13, the particle bin 12 of the film coating layer 1 and the drug application layer 11 need to be careful to correspond to the mesh openings of the woven mesh of the stent 3, so that the particle bin layer 12 and the drug application layer 11 can contact with the wall tissues of the lumen, thereby performing particle radiotherapy and slow release anesthesia on the surrounding tumors. The upper and lower rand 13 is fixed the back tectorial membrane layer 1 of equal chucking and can hug closely in support inner wall, and the cooperation of upper and lower opposite chucking makes whole structure fixed more firm. The slow-release anesthetic cavities 132 of the upper and lower collars 13 can release anesthetic liquid medicine to the wall of the patient lumen all the time while being clamped stably, and the slow-release anesthetic in solid state in the medicine application layer 11 of the film coating layer 1 is matched with the iodine 125 in the particle bin layer 12 to treat tumors.

The local anesthesia slow-release drug coating stent and the conveying and applying system have the following advantages:

1. the film coating layer 1 is separated from the support 3 and exists independently, so that a patient can treat tumors on the inner wall of the tube cavity by keeping the film coating layer 1 and the original support 3 relatively fixed without replacing the support 3, and unnecessary damage to the patient and increase of operation treatment cost in the process of replacing the support 3 are avoided; meanwhile, the design also enables the film coating layer 1 to be convenient to replace or withdraw, and great convenience is provided for subsequent operation. The plurality of spirally arranged particle bin layers 12 which are uniformly distributed on the circumference of the film covering layer 1 and the drug application layer 11 which is provided with the plurality of film covering permeation holes 111 can be loaded with iodine 125 particles and slow-release anesthetic to treat tumors.

2. The support that rand 13 connected on laminating layer 1 set up presss from both sides tight groove 131 and conveniently carries out the chucking to the last lower port department of support 3 thereby makes laminating layer 1 and support 3 fixed unable pine of chucking in opposite directions take off, and rand 13 leans on the rand permeation hole 135 of two mutual intercommunications of position design about the outside slow release anesthesia medicine chamber 132 that communicates about the outside to make the inside slow release anesthesia medicament of medicine chamber continuously stable play the slow release anesthesia effect to the pipe intracavity wall.

3. The inclined planes 134 at the ports of the upper and lower collars 13 are designed to be matched with the upper layer balloon 221 after being inflated and the receding groove surface 223 at the circumference of the middle outer ring of the lower layer balloon 231 for embedding and clamping, so that the collars 13 can be propped open, and the collars 13 can be clamped at the ports of the stent 3 conveniently. The purpose of the two cavities formed by the spacer layer is to support the upper balloon 221 through the spacer layer, so that the upper balloon 221 has certain strength in the middle position of the inflated outer ring, and is not easy to dent and deform after being pressed like other areas of the upper balloon 231.

In the present invention, as shown in fig. 15 to 28, the present invention provides an embodiment one, in the embodiment one, a spiral furling tube 218 is disposed in the first sleeve 21, a conduit head 232 is disposed at the lower end of the third sleeve 23, a tightening sleeve 233 is coaxially connected to the conduit head 232, a clamping support 224 is sleeved between the second sleeve 22 and the tightening sleeve 233, the spiral furling tube 218 can be sleeved on the clamping support 224, and a film layer 1 is sleeved between the clamping support 224 and the spiral furling tube 218; the first sleeve 21, the second sleeve 22 and the third sleeve 23 are all provided with handle ends 25; specifically, the catheter mechanism 2 is also provided with a second sleeve 22 and a third sleeve 23 which are sequentially sleeved on the first sleeve 21 from the outside to the inside, and a linear handle end 25 arranged at the rear manipulating end of the first sleeve 21, the second sleeve 22 and the third sleeve 23 is identical to the catheter mechanism 2. The closing cavity 211 at the lower end of the first sleeve 21 is internally provided with a spiral closing pipe 218, the spiral closing pipe 218 is cylindrical as a whole, and the inner wall of the spiral closing pipe 218 is in a spiral ridge-type sharp-angled shape which is uniformly distributed along the circumference and faces the axial direction. The coiled tube 218 is longer than the clamping stent 224 in an elongated tightened state so that the clamping stent 224 can be fully retracted inside the coiled tube 218. The inner wall of the second sleeve 22 at the front end port sleeved inside the first sleeve 21 is designed into a step-shaped structure to a certain depth area inwards, so that the wall thickness of the inner wall at the front end port of the second sleeve 22 is smaller than that of the rest positions. The third sleeve 23 is sleeved inside the second sleeve 22, the front section of the third sleeve 23 can extend out of the second sleeve 22 and extend for a certain distance, the conical catheter head 232 is coaxially and fixedly connected with the front end port of the third sleeve 23, the tightening sleeve 233 is coaxially fixed on the rear end surface of the catheter head 232, the tightening sleeve 233 is integrally sleeve-shaped, the tightening sleeve 233 is sleeved on the third sleeve 23 in a clearance fit manner, and the inner wall of the tightening sleeve is spaced from the wall of the third sleeve 23. The clamping bracket 224 is sleeved between the front section of the second sleeve 22 sleeved on the third sleeve 23 and the inner wall of the tightening sleeve 233 and the pipe wall of the third sleeve 23, and the length of the clamping bracket 224 is longer than that of the bracket 3. The front end of the second sleeve 22 and the tightening sleeve 233 are tightened on the two ends of the clamping bracket 224, respectively, so that the spiral furling tube 218 at the front end of the first sleeve 21 can be sleeved outside the clamping bracket 224 when the first sleeve 21 is pushed forward to push against the catheter head 232. When the helical furling tube 218 is withdrawn to expose the clamping stent 224 section, the clamping stent 224 can be released by manually controlling the handle ends of the second sleeve 22 and the third sleeve 23 to increase the relative distance between the second sleeve 22 and the tightening sleeve 233. The coating layer 1 is sleeved between the clamping bracket 224 and the spiral furling tube 218, and the coating layer 1 of the first embodiment is identical to the coating layer 1 in structure and is not described in detail.

In the first embodiment, in the initial state, the clamping support 224 is first pulled to be elongated, and both ends of the clamping support are respectively bound inside the front section of the second sleeve 22 and the tightening sleeve at the rear end of the catheter head 232, the coating layer 1 is wrapped around the outer periphery of the clamping support 224, and the first sleeve 21 is pushed forward, so that both the clamping support 224 and the coating layer 1 are folded and sleeved inside the spiral folding tube 218. The plurality of spiral ridge type sharp angles uniformly distributed along the circumference of the inner wall of the spiral furling pipe 218 along the axial direction can prevent the occurrence of the relative slippage, even the slippage and the like of the film coating layer 1 and the clamping bracket 224, when the first sleeve 21 is pulled backwards relative to the second sleeve 22 and the third sleeve 23 to drive the spiral furling pipe 218 to gradually release the film coating layer 1 and the clamping bracket 224, the spiral ridge type sharp angles on the inner wall of the spiral furling pipe 218 can play a role in stabilizing the film coating layer 1 and the clamping bracket 224 at the unreleased section all the time, and the film coating layer 1 and the clamping bracket 224 can be kept relatively fixed all the time before completely separating from the spiral furling pipe 218. When the spiral furling tube 218 pulls back along the first sleeve 21 to completely release the tightening sleeve and the clamping support 224, only the front end stage of the second sleeve 22 and the tightening sleeve 233 tighten the two ends of the clamping support 224, the second sleeve 22 is pushed forward, and the third sleeve 23 is pulled backward at the same time, so that the relative distance between the second sleeve 22 and the tightening sleeve 233 is reduced, the middle section of the clamping support 224 is expanded and bulged under the pushing action of the rear end face of the front end catheter head 232 of the tightening sleeve 233 and the end face of the stage end face of the second sleeve 22, so that the clamping support 223 integrally forms a shape with two thin ends and thick middle, and the middle section of the clamping support 224 supports the film-coated layer 1 to be tightly attached to the lumen inner support 3. After the relative position of the film-coated layer 1 and the stent 3 is determined, the third sleeve 23 is pushed forward, the third sleeve 23 drives the tightening sleeve 233 to push forward, so that the front end port of the clamping stent 224 is gradually separated from the tightening sleeve 233, and finally the front end of the clamping stent 224 completely releases the top support to the inner wall of the lumen, so that the clamping stent 224 is relatively fixed with the wall of the lumen. At this time, the second sleeve 22 is pulled backwards, the other end of the clamping support 224 is released to enable the clamping support 224 to complete propping to the inner wall of the tube cavity, and the film coating layer 1 is completely clamped and fixed between the support 3 and the clamping support 224, so that the cake-shaped solid slow-release anesthetic matched with the iodine 125 particles in the film coating layer 1 treats tumors on the inner wall of the tube cavity.

The first embodiment has the following advantages:

1. adopt length to be longer than the tight support 224 of the clamp of support 3 with laminating layer 1 press from both sides tightly between support 3 and the tight support 224 of clamp for laminating layer 1 is fixed completely thereby carries out radiotherapy to the lumen inner wall, this kind of mode can change the tight support of clamp that corresponds wantonly according to the length of original support 3 and specification, it treats to have the general type doctor of being convenient for, conventional laminating formula support hugs closely because length laminating support is short treatment inadequately or laminating support overlength causes the unsettled unable treatment of laminating to the lumen inner wall of medicine to appear on original support.

2. The step section of the second sleeve 22 and the tightening sleeve 233 tighten the two ends of the clamping support 224, the spiral drawing tube 218 draws in the middle section of the clamping support 224 and tightens, so that the clamping support 224 can be tightened completely, and the spiral ridge type sharp corner on the inner wall of the spiral drawing tube 218 plays a stabilizing role in the film coating layer and the clamping support 224 which are not released, the film coating layer 1 and the clamping support 224 can be kept fixed relative to each other all the time before being completely separated from the spiral drawing tube 218, the clamping support 224 is convenient for controlling the film coating layer 1 to be attached to the accurate position of the support 3, and the stage end face and the rear end face of the front end guide pipe head of the tightening sleeve 233 play a role in pushing and pulling.

3. The adoption can be when releasing the inflation uplift of control clamp support 224 interlude to clamp support 224 whole forms thick shape in the middle of the thin both ends, and the interlude that presss from both sides clamp support 224 props tectorial membrane layer 1 to hugging closely with lumen inside support 3, makes tectorial membrane layer 1 hug closely follow-up complete release again after the alignment position, has very high fault-tolerant rate, avoids appearing directly tightening the state release by slender like traditional support release mode, can't slide after the deviation appears in the position.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (8)

1. A local anesthesia slow-release drug coating stent and a conveying and applying system are characterized by comprising a film coating layer and a catheter mechanism, wherein the film coating layer is used for clinging to the stent, and the catheter mechanism is used for conveying the film coating layer into a lumen and clinging to the stent; a drug application layer for attaching a solid slow-release anesthetic and a particle bin layer for loading radioactive particles are uniformly distributed on the film coating layer; the catheter mechanism comprises a first sleeve, a second sleeve sleeved in the first sleeve and a third sleeve sleeved in the second sleeve, a guide wire penetrates through the third sleeve, the film coating layer is sleeved in the first sleeve and is positioned between the second sleeve and the third sleeve, and the third sleeve stretches out of the second sleeve and then pulls open the film coating layer to be attached to a support;

a furling cavity is arranged in the first sleeve, an upper layer balloon is connected to the outer wall of the lower end of the second sleeve, a lower layer balloon is connected to the outer wall of the lower end of the third sleeve, and the furling cavity can furl the upper layer balloon and the lower layer balloon; a first air passage is arranged in the first sleeve, a first inflation tube is arranged in the first air passage, and the upper layer balloon is communicated with a first inflation one-way valve joint through the first inflation tube; a second air passage is arranged in the third sleeve, a second inflation tube is arranged in the second air passage, and the lower layer balloon is communicated with a second inflation one-way valve joint through the second inflation tube;

the film laminating device is characterized in that a spiral furling pipe is arranged in the first sleeve, a guide pipe head is arranged at the lower end of the third sleeve, a tightening sleeve is coaxially connected to the guide pipe head, a clamping support is sleeved between the second sleeve and the tightening sleeve, the spiral furling pipe can sleeve the clamping support, and the film laminating layer is sleeved between the clamping support and the spiral furling pipe.

2. The local anesthesia slow-release drug-coated stent and delivery application system of claim 1, wherein the upper balloon and the lower balloon are provided with two balloon cavities.

3. The local anesthesia slow-release drug-coated stent and delivery application system of claim 2, wherein the upper and lower ends of the membrane layer are provided with collars, and the collars are provided with stent clamping grooves for being clamped on the stent.

4. The local anesthesia slow release drug coated stent and delivery application system of claim 3, wherein said clamp ring is provided with two slow release anesthetic cavities for storing slow release anesthetic, and said slow release anesthetic cavities are provided with collar penetration holes.

5. The local anesthesia slow release drug coated stent and delivery application system of claim 4, wherein two of said slow release anesthetic lumens are connected by a communicating channel.

6. The local anesthesia slow-release drug-coated stent and delivery application system of claim 5, wherein the clamping ring is provided with an inclined surface, and the outer rings of the upper balloon and the lower balloon are provided with abdication groove surfaces matched with the inclined surface.

7. The local anesthesia slow release drug coated stent and delivery application system of claim 6, wherein said drug application layer is provided with a plurality of membrane penetration holes.

8. The local anesthesia slow release drug coated stent and delivery application system of claim 1, wherein the first, second and third sleeves are provided with handle ends.

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