CN109806667A - Protein antivirus protection obstructs biological agent and preparation method - Google Patents
Protein antivirus protection obstructs biological agent and preparation method Download PDFInfo
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- CN109806667A CN109806667A CN201910038497.9A CN201910038497A CN109806667A CN 109806667 A CN109806667 A CN 109806667A CN 201910038497 A CN201910038497 A CN 201910038497A CN 109806667 A CN109806667 A CN 109806667A
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Abstract
The invention discloses a kind of preparation methods of protein antivirus protection barrier biological agent, it include: to prepare biological nano mesoporous material, preparation specific binding receptor or ligand, configuration protection filtered fluid, the solution for the certain proportion concentration that step 1 and step 2 obtain is mixed and reacted, vacuum distillation obtains protection filtered fluid；Multi-layer film structure medium is made, is squeezed by solvent casting, semi-solid casting, hot melt extruded (HME), solid dispersion or rolling synthesizes in membrane polymer, the partially liq formation film being then added by molding and/or evaporation；Prepare protein antivirus protection barrier biological agent, by step 3 obtain protection filtered fluid soak at room temperature or high pressure painting in step 4 made of film two sides.The small particle nano material of high activity prepared by the present invention; in addition special technique; so that the pollutant of bulky grain can not only effectively be filtered and be stopped; and can effectively small particles such as viral adsorption, bacterium or anaphylactogen poisonous and harmful substance; to provide comprehensive protection for people; worldwide being proposed for the first time has the function of the comprehensive efficient prevention of infectious disease, has guarded people's health.
Description
Technical field
The invention belongs to poisonous and harmful substances to protect field, and in particular to a kind of protein antivirus protection barrier biological agent
And preparation method thereof, filter face mask, air filter, air purifier etc..
Background technique
It is got over the time of work and life in closed environment with living-pattern preservation, people with the improvement of living standards
It more grows, the places such as hospital, school, theater, the vehicle interiors such as automobile, aircraft, high-speed rail belong to viral transmission to lead
Cause the severely afflicated area of cross-infection.People think always air pollution, and the serious is external environments.And in fact, office, room,
Influence of the indoor environment of the buildings such as restaurant, cinema, dancing hall to health of people is much greater more than outdoor.
Such as indoor pollutant, it is mainly derived from following 5 aspects: first is that human body respiration, flue gas；Second is that finishing material
Material, articles for daily use；Third is that microorganism, virus, bacterium；Fourth is that kitchen fume；Fifth is that air conditioner comprehensive disease.Exist in air indoors
More than 500 kinds of volatile organic matters, wherein carcinogen just has more than 20 kinds, more than 200 kinds of Causative virus.Endangering biggish mainly has:
Formaldehyde, benzene,toluene,xylene, TVOC, ammonia etc. and various harmful bacterias and microorganism etc..These pollutants with breathe into
Enter inside of human body, long-term accumulation seriously endangers the health of people.
For another example henpecked narrow space, closed is feared in the closed traffic such as automobile or aircraft, pollutant do not allow it is volatile, especially
When the irradiation of summer sunlight and winter open heating, in-vehicle exposure object can largely be assembled.Benzene,toluene,xylene, benzene second in air
This 8 kinds of carcinogenic substances of alkene, ethylbenzene, formaldehyde, acetaldehyde and methacrylaldehyde, they are from three aspects: first is that accessories, such as cover for seat, headrest.Two
Automobile interior decoration, such as leather seat, glue.Third is that diluent needed for production, glue paint and coating etc..In addition, by
The harmful exhaust of engine discharge, such as carbon monoxide, carbon dioxide can also endanger health.The pollutant of the car such as high-speed rail train
Mainly have two big sources: one is external, including arriving at a station, the open the door outdoor air entered, a large amount of passengers gets on the bus the pollution brought into
Object etc.；It is another then generated in intra-locomotive, including locomotive element and interior decoration materials, paint, glue, bonding
Agent, seat trim product etc..Locomotive element and interior decoration materials release pollutant mainly have benzene, toluene, formaldehyde, alkene,
Aromatic hydrocarbon etc., the harmful substance pollutant for being externally entering compartment mainly have the pollution of the hazes such as PM2.5, harmful bacteria, virus etc..
These harmful substances can make rider the malaise symptoms such as dizzy, nauseous, sleepy, cough and asthma, sneezing occur.And first therein
Aldehyde, ammonia, benzene, dimethylbenzene and other volatile organic matters are in addition to it can cause acute irritation effect, if people is chronically at high concentration ring
In border, it can also cause the damage of respiratory system, liver, kidney and blood forming organ, the change of immune function, or even exist and induce cancer
It is dangerous.
The common protection method of people has mask, air purifier etc. at present, and general mask is by mask portion and mask
Band composition, mask portion are the fibrous layer for filtering, generally use non-woven fabrics or gauze, are obstructed by the logistics of the main body of mask
Mode blocks particle.This mode can play a role the biggish dust granule of partial size, but lesser to many partial sizes
There is no useful effects for virus, bacterium, allergenic agent etc..For example, common N95 mask can not be effectively prevented influenza disease
The propagation of poison.
For this purpose, people have developed protective device and activated-carbon device with charge, pass through the electronics and active carbon of charge
Filtering come viral adsorption and toxin.But experiment and practice have shown that, the former have charge in the case where can play a role,
Thick intelligence has suction-operated to a small amount of non-specific particle.Therefore both modes still cannot effectively Specific adsorption virus and
Bacterium, it is more difficult to absorption and the interception smaller allergen molecule of partial size.For pathogenic microorganisms such as bacterium and viruses through breathing
The disease that road is propagated can not play useful effect.
Similarly, air purifier is typically also that can play certain block for large-sized substance using similar principle
Effect is cut, but useful effect can not be generated for virus, bacterium and allergen molecule etc..
Summary of the invention
The present invention is based on the above problems, and from practice and theoretic, in conjunction with experience abundant and professional knowledge, cooperation is learned
Reason can be widely applied for each neck and ring to invent a kind of protein antivirus protection barrier biological agent and preparation method thereof
A variety of poisonous and harmful substances such as virus, bacterium and allergenic agent are prevented in border.
In order to achieve the above object, the invention adopts the following technical scheme:
Wherein, the preparation method of protein antivirus protection barrier biological agent includes:
Step 1: preparing biological nano mesoporous material, including monodimension nanometer material, two-dimension nano materials, porous nano material
Material the processing steps such as extracts by raw material preparation, purification, structure and morphology characterization, photocatalysis, stirring when preparation, obtains
Nano-adsorption materials；
Step 2: preparation specific binding receptor or ligand, as needed by specific binding receptor recited above or
One of ligand or it is a variety of it is any be mixed and made into solution, solution is made of aqueous solution, weight percent concentration 1-10%；
Step 3: configuration protection filtered fluid, the solution for the certain proportion concentration that step 1 and step 2 obtain is mixed
It closes and reaction, vacuum distillation obtains protection filtered fluid；
Step 4: production multi-layer film structure medium, passes through solvent casting, semi-solid casting, hot melt extruded (HME), solid
Dispersion squeezes or rolling synthesizes in membrane polymer, the partially liq formation film being then added by molding and/or evaporation；
Step 5: preparing protein antivirus protection barrier biological agent, the protection filtered fluid that step 3 is obtained passes through normal
Temperature is impregnated or the two sides of high pressure painting film made of step 4.
Preferably, the nano material in above-mentioned steps one is titania precursor body, is selected from tetraethyl titanate, butyl titanate, titanium
One of propyl propionate is a variety of；The preparation of nano material includes hydrothermal/solvent thermal method, sol-gel method, template, electrostatic
One of spin processes or coprecipitation are a variety of.
Preferably, purification is completed by following steps in above-mentioned steps one:
Step 1.1 takes 0.1g sample lower pretreatment 60 minutes under nitrogen or argon gas (flow 30mL/min) atmosphere, from
So it is cooled to 100 DEG C；
Step 1.2, the Balance Air that NH3-Ar (5%NH3) is passed through into sample are extremely saturated for absorption 60 minutes；
After step 1.3, absorption, with the NH3 of He purging physical absorption；
Step 1.4 is increased to 700 DEG C with the heating rate of 10 DEG C/min, and the ammonia of desorption enters gas chromatograph progress
On-line analysis determines acid amount and acid strength according to peak area and peak position.
Preferably, photocatalysis specifically includes in above-mentioned steps one: the accurate 2L distilled water that measures is packed into reactor, opens constant current
Pump, recycles the distilled water in reactor, opens simultaneously air pump；10mL methylene blue solution is accurately measured again, is placed in reaction
In device, object mixing to be mixed takes first sample after ten minutes；Accurately weigh 0.2000g catalyst sample be added reactor, to be adsorbed 30
First sample after taking absorption after minute.
Preferably, above-mentioned steps three specifically include:
Different solution is stirred 1-10 hours by step 3.1 according to the proportion, obtains mixed solution；
Alcoholic solution mixing is added into mixed solution for step 3.2, stirs 1-12 hours, obtains containing nano-active material
Alcohol disperses solution；
Step 3.3 carries out sour water solution to alcohol dispersion solution, and the acid is in formic acid, acetic acid, ethanedioic acid, hydrochloric acid, nitric acid
It is one or more.
Preferably, the aqueous hydrochloric acid solution that above-mentioned acid solution is 20-40% using concentration.
Preferably, ultraviolet lamp is opened after above-mentioned photocatalysis and is started with manual time-keeping, takes a sample every 5 minutes, 3 hours
Stop sampling afterwards.
Preferably, ultraviolet lamp is opened after stopping sampling and starts to use manual time-keeping, a sample is taken every 5 minutes, after 3 hours
Stop sampling.Each sample is placed in cuvette through water system film (0.22 μm of aperture) filtering respectively, using distilled water as reference, is surveyed
The a length of 664nm of standing wave carries out absorbance measurement.
Preferably, the film of above-mentioned steps five includes multilayered structure, and aperture is sequentially reduced from outside to inside.
Preferably, above-mentioned medium is to be diluted shape by certain proportion according to the protection filtered fluid that the step 3 configures
At aqueous solution.
Present invention simultaneously provides a kind of protein antivirus protections to obstruct biological protection filter face mask, includes multilayered structure
Cover, sets gradually filter layer, adsorption layer and secondary filtration layer from outside to inside, and filter layer, adsorption layer and secondary filtration layer soak
Bubble such as above-mentioned filter medium.
Present invention simultaneously provides a kind of protein antivirus protections to obstruct biological protection filter screen, is the material system of certain pore size
At being formed by for example above-mentioned filter medium of soak at room temperature or high-pressure fog.
Present invention simultaneously provides a kind of protein antivirus protections to obstruct biological protection filter, including such as above-mentioned protein
Antivirus protection obstructs biological protection filter screen, shell, filter tip, air guide port, exhaust outlet and power supply device.
Present invention simultaneously provides a kind of air purifiers, obstruct biological protection including such as above-mentioned protein antivirus protection
Strainer, motor, fan, intelligent monitor system, external component, filter element, air duct, motor and power supply.
Present invention simultaneously provides a kind of air cleaning fresh air system, including blower, air inlet, exhaust outlet and various pipelines and
Connector, air inlet are provided with above-mentioned protein antivirus protection such as and obstruct biological protection filter screen.
The small particle nano material of high activity prepared by the present invention, in addition special technique, so that can not only effectively filter
With the pollutant for stopping bulky grain, and can effectively small particles such as viral adsorption, bacterium or anaphylactogen poisonous and harmful substance,
To provide comprehensive protection for people, worldwide it is proposed for the first time with the comprehensive efficient prevention of infectious disease
Function has guarded people's health.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, will make below to required in the embodiment of the present invention
Attached drawing is briefly described, for those of ordinary skill in the art, without creative efforts, also
Other drawings may be obtained according to these drawings without any creative labor.
Fig. 1 is gas phase chromatographic device schematic diagram of the present invention；
Fig. 2 is that photocatalysis of the present invention uses homemade intermittent cycle slurry photocatalytic reactor schematic diagram；
Fig. 3 is the XRD spectra that the present invention reacts 10 hours obtained nano materials under 180 DEG C of hydrothermal conditions；
Fig. 4 is the TEM spectrogram that the present invention reacts 10 hours obtained nano materials under 180 DEG C of hydrothermal conditions.
Specific embodiment
The feature and exemplary embodiment of various aspects of the invention is described more fully below, in order to make mesh of the invention
, technical solution and advantage be more clearly understood, with reference to the accompanying drawings and embodiments, the present invention is further retouched in detail
It states.It should be understood that specific embodiment described herein is only configured to explain the present invention, it is not configured as limiting the present invention.
To those skilled in the art, the present invention can be real in the case where not needing some details in these details
It applies.Below the description of embodiment is used for the purpose of better understanding the present invention to provide by showing example of the invention.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence " including ... ", it is not excluded that including
There is also other identical elements in the process, method, article or equipment of the element.
The present invention provides a kind of preparation methods of protein antivirus protection barrier biological agent, comprising:
Step 1: preparing biological nano mesoporous material, including monodimension nanometer material, two-dimension nano materials, porous nano material
Material the processing steps such as extracts by raw material preparation, purification, structure and morphology characterization, photocatalysis, stirring when preparation, obtains
Nano-adsorption materials；
Step 2: preparation specific binding receptor or ligand, as needed by specific binding receptor recited above or
One of ligand or it is a variety of it is any be mixed and made into solution, solution will be made of water, weight percent concentration 1-10%；
Step 3: configuration protection filtered fluid, the solution for the certain proportion concentration that step 1 and step obtain is mixed
And reaction, vacuum distillation obtain protection filtered fluid；
Step 4: production multi-layer film structure medium, passes through solvent casting, semi-solid casting, hot melt extruded (HME), solid
Dispersion squeezes or rolling synthesizes in membrane polymer, the partially liq formation film being then added by molding and/or evaporation；
Step 5: preparing protein antivirus protection barrier biological agent, the protection filtered fluid that step 3 is obtained passes through normal
Temperature is impregnated or the two sides of high pressure painting atomization process film made of step 4.
Wherein, the nano material in step 1 is titania precursor body, is selected from tetraethyl titanate, butyl titanate, titanium propanolate
One of or it is a variety of；The preparation of nano material includes hydrothermal/solvent thermal method, sol-gel method, template, method of electrostatic spinning
Or one of coprecipitation or a variety of.
Wherein, purification is completed by following steps in step 1:
Step 1.1 takes 0.1g sample to pre-process 60 minutes under nitrogen or argon gas (flow 30mL/min) atmosphere, natural
It is cooled to 100 DEG C；
Step 1.2, the Balance Air that NH3-Ar (5%NH3) is passed through into sample are extremely saturated for absorption 60 minutes；
After step 1.3, absorption, with the NH3 of He purging physical absorption；
Step 1.4 is increased to 700 DEG C with the heating rate of 10 DEG C/min, and the ammonia of desorption enters gas chromatograph progress
On-line analysis determines acid amount and acid strength according to peak area and peak position.
Wherein, photocatalysis specifically includes in step 1: the accurate 2L distilled water that measures is packed into reactor, opens constant flow pump, makes
Distilled water circulation in reactor, opens simultaneously air pump；10mL methylene blue solution is accurately measured again, is placed in reactor,
Object mixing to be mixed takes first sample after ten minutes；It accurately weighs 0.2000g catalyst sample and reactor is added, after 30 minutes to be adsorbed
First sample after taking absorption.
Wherein, step 3 specifically includes:
Different solution is stirred 1-10 hours by step 3.1 according to the proportion, obtains mixed solution；
Alcoholic solution mixing is added into mixed solution for step 3.2, stirs 1-12 hours, obtains containing nano-active material
Alcohol disperses solution；
Step 3.3 carries out sour water solution to alcohol dispersion solution, and the acid is in formic acid, acetic acid, ethanedioic acid, hydrochloric acid, nitric acid
It is one or more.
Wherein, the aqueous hydrochloric acid solution that acid solution is 20-40% using concentration.
Ultraviolet lamp is opened after photocatalysis and starts to use manual time-keeping, and a sample was taken every 5 minutes, stops sampling after 3 hours.
Ultraviolet lamp is opened after stopping sampling and starts to use manual time-keeping, and a sample was taken every 5 minutes, stops sampling after 3 hours.Each sample
All it is placed in cuvette through water system film (0.22 μm of aperture) filtering respectively, using distilled water as reference, measurement wavelength is 664nm,
Carry out absorbance measurement.
Wherein, the film of step 5 includes multilayered structure, and aperture is sequentially reduced from outside to inside.
It is situated between the present invention also provides a kind of according to the protein antivirus protection barrier biological protection filtering of above method preparation
Matter, medium are that the protection filtered fluid configured according to the step 3 is diluted the aqueous solution to be formed by certain proportion.
The present invention also provides a kind of protein antivirus protections to obstruct biological protection filter face mask, includes multilayered structure
Cover, sets gradually filter layer, adsorption layer and secondary filtration layer from outside to inside, and filter layer, adsorption layer and secondary filtration layer soak
Steep filter medium as described above.
The present invention also provides a kind of protein antivirus protections to obstruct biological protection filter screen, is the material system of certain pore size
At being formed by soak at room temperature or high pressure painting atomization process filter medium as described above.
The present invention also provides a kind of protein antivirus protections to obstruct biological protection filter, including albumen as described above
Matter antivirus protection obstructs biological protection filter screen, shell, filter tip, air guide port, exhaust outlet and power supply device.
The present invention also provides a kind of air purifiers, including protein antivirus protection as described above to obstruct biological protection
Filter screen, motor, fan, intelligent monitor system, external component, filter element, air duct, motor and power supply.
The present invention also provides a kind of air cleaning fresh air system, including blower, air inlet, exhaust outlet and various pipelines and
Connector, air inlet are provided with protein antivirus protection barrier biological protection filter screen as described above.
In some embodiments, provide a kind of gas phase chromatographic device as shown in Figure 1, including A absorption, AIC analysis and Control,
CV check valve, F filter, FV flow stabilizing valve, the control of FIC flow indication, H heater, HV shut-off valve, MF mass flowmenter, RV pressure
Force regulating valve, RF spinner flowmeter, TI temperature display, the control of TIC temperature display, TCD thermal conductivity detector (TCD) and 6V six-way valve.
In some embodiments, as shown in Fig. 2, photocatalysis of the invention uses homemade intermittent cycle slurry photocatalysis
Reactor is evaluated using the photocatalysis that methylene blue solution carries out nanometer powder as simulating pollution object.Photocatalysis apparatus by reactor,
The composition such as ultraviolet lamp, constant flow pump, air pump.Air has bottom gas inlet introducing, and the reaction solution in reactor is by bottom with whirlpool
Stream mode, which is exported, is pumped to reactor head through water, and catalyst deposit can be prevented in bottom, be sufficiently mixed reaction solution, and can be really
It protects reaction solution and keeps circulation.
In some embodiments, light-catalysed to comprise the concrete steps that the accurate 2L distilled water that measures is packed into reactor, open constant current
Pump, recycles the distilled water in reactor, opens simultaneously air pump；10mL methylene blue solution is accurately measured again, is placed in reaction
In device, object mixing to be mixed takes first sample after ten minutes；Accurately weigh 0.2000g catalyst sample be added reactor, to be adsorbed 30
First sample after taking absorption after minute.It opens ultraviolet lamp and starts to use manual time-keeping, a sample was taken every 5 minutes, is stopped after 3 hours
Sampling.Each sample is placed in cuvette through water system film (0.22 μm of aperture) filtering respectively, using distilled water as reference, measures wave
A length of 664nm carries out absorbance measurement.The photocatalysis that sample is evaluated using the residual rate of methylene blue solution after reaction is living
Property.According to formula: A=-0.0258+0.1973C calculates the concentration of each sample point Liquid Residue, and then it is sub- to calculate each sample point
The residual rate C of methyl bluet/C0。
In some embodiments, as shown in Figures 3 and 4,10 hours obtained nano materials are reacted under 180 DEG C of hydrothermal conditions
XRD and TEM spectrogram, from XRD diagram as can be seen that the nano material made from this system present pseudohexagonal crystalline system structure.
31mL benzyl alcohol is added into appropriate titania precursor liquid solution, the mixture is then placed in tetrafluoroethene liner
Reaction kettle in, at 180 DEG C, 10 hours taking-up chillings are reacted in rotating kettle, through low-speed centrifugal (4500r/ minutes) ethyl alcohol
It washes 4 times, it is 2 hours dry in 80 DEG C, white powder is obtained, is risen to after white powder is ground with 2 DEG C/min of heating rate
580 DEG C roast 1 hour, obtain final product rod-like nano titanium dioxide.
During preparation, following characteristics are found:
(1) with the increase of benzyl alcohol amount, the crystallinity of product first increases to be reduced afterwards, and stick length also presents first to increase to be subtracted afterwards
Trend；
(2) with the extension of reaction time, the crystallinity variation of products therefrom is unobvious, and pattern is gradually by randomly growing up to stick
Shape, reaction time are that whole club shaped structures can be obtained in 10 hours；
(3) with the raising of reaction temperature, obtained product crystallinity is gradually increased, and club shaped structure becomes uniform.
Compare different material than obtaining photocatalysis and the surface acidity of sample, is concluded that
(1) stick length is bigger, and photocatalytic activity is stronger, and surface acidity is weaker；The photocatalytic activity of sample mainly by
The factors such as its Crystal, specific surface area, acid amount and sour position codetermine；Surface acidity is then mainly by catalyst surface acid kind
Class, acid strength and acid amount determine；
(2) sample that molar ratio is 1:21 has highest light reaction, and the degradation rate of 180 minutes methylene indigo plant exists
65% or so, 1:86 and 1:200 prepare sample activity it is roughly the same be 46% or so；
(3) molar ratio is the sample surface acidity highest of 1:43, and the highest yield of dimethyl ether is 50%, 1:200 ratio
The highest yield of obtained sample is 40% or so, and the sample surface acidity of molar ratio 1:21 is minimum, only 30% or so.
In some embodiments, surface plasma resonance (SPR) is one of important enhancing mechanism of surface-enhanced Raman, by
The resonance for causing metal free electron is irradiated by exciting light in the dimensional effect and quantum effect of precious metal ion.Metal surface
Valence electron regard moving electron gas under uniform positive charge background as, when plasma (orifice) gas is by electromagnetic interference, metal inside
Electron density distribution becomes uneven.Since the presence of Coulomb force makes the electronics to have gathered together leave the region again, because
This, will form a kind of collective's concussion of electronic system, and this concussion is known as plasma concussion, and is showed in the form of wave,
It is referred to as ion wave.When illumination is mapped on metal surface, since total reflection phenomenon occurs for the difference of refractive index, and in air and gold
Belong to interface and generates evanescent waves.There may be resonance when evanescent waves and the intracorporal ion wave of metal meet, when generating resonance, energy from
Photon is transferred to surface plasma, and incident light is largely absorbed, and reflective light intensity can significantly weaken.For metal nano
Particle, in the presence of electromagnetic wave, electrons undergo a kind of concussion of communality, since this resonance is under specific frequency
Just occur, therefore referred to as local surface plasma resonance (LSPR).In terms of microcosmic angle, local surface plasma is total
Vibration (LSPR) is confined to photon in the nanostructure of small scale, increased dramatically surrounding electric field；In terms of macroscopic perspective, local table
Surface plasma resonance (LSPR) weakens reflected light sharply, and incident light and scattering light sharply enhance.
In some embodiments, in the local surface plasma resonance frequency (ω of research nano materialsp), it is to be answered by it
Close what dielectric constant determined.
One nano-crystalline granule can similar be an electrode, when a metal cluster is placed in the electric field, in electric field force
Under the action of, positive and negative charge just separates, and generates polarity
Define sphere polarity be
It is the dielectric constant of metallic particles, ε=ε for ε1(ω)+iε2(ω), ε1(ω)、ε2(ω) is respectively metallic particles
Dielectric constant real and imaginary parts.
Make to generate resonant check, i.e., to meet condition | ε1(ω)+2εm|=minimum --- --- is 1.
Wherein ε1The real part of the dielectric constant of (ω) metallic particles.
By De Nu get (Drude) model εr=1- ωp 2/(ω2+γ2)————②
ωspFor local surface plasma resonance (LSPR) energy, γ is the half-peak breadth of plasma resonance band, can be from suction
Receive the parameter read in spectrum.
By 1., ω 2. can be releasedp=(Nhe2/ε0mh)1/2,NhFor the concentration in free carrier (hole), mhFor hole
Effective mass.
When being prepared for nano lamellar material using solvent heat, and having investigated the ratio, reaction temperature, reaction of raw material and solvent
Between, the influence for the material structure and pattern and investigate its relation be- tween structure and properties, it is available to draw a conclusion:
(1) under the conditions of mutually synthermal and dicyandiamide solution, there is a fixing in the extension reaction time to nanometer material structure and pattern
Sound, only the reaction time available relatively uniform sheet of pattern at 24 hours or so；To obtain long sheet-like morphology, react
Time will be at 60 hours or more；
(2) reaction temperature is affected for the structure of product, and temperature more high-crystallinity is higher, and the influence for pattern
It is not very greatly, as long as temperature reaches 180 DEG C of available laminated structures of uniform morphology；
(3) catalytic activity of sample is codetermined by factors such as its Crystal, specific surface area, acid amount and sour positions, than
Surface area is bigger, and acid amount is more, and surface acidity is higher；Acid strength is stronger, and surface acidity is higher；Crystallinity is higher, acid catalysis
Activity is higher.
The small particle nano material of high activity prepared by the present invention, in addition special technique, so that can not only effectively filter
With the pollutant for stopping bulky grain, and can effectively small particles such as viral adsorption, bacterium or anaphylactogen poisonous and harmful substance,
To provide comprehensive protection for people, worldwide it is proposed for the first time with the comprehensive efficient prevention of infectious disease
Function has guarded people's health.
It should also be noted that, the terms "include", "comprise" or its any other variant are intended to nonexcludability
It include so that the process, method, commodity or the equipment that include a series of elements not only include those elements, but also to wrap
Include other elements that are not explicitly listed, or further include for this process, method, commodity or equipment intrinsic want
Element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that including described want
There is also other identical elements in the process, method of element, commodity or equipment.
All the embodiments in this specification are described in a progressive manner, same and similar portion between each embodiment
Dividing may refer to each other, and each embodiment focuses on the differences from other embodiments.Especially for system reality
For applying example, since it is substantially similar to the method embodiment, so being described relatively simple, related place is referring to embodiment of the method
Part explanation.
The above description is only an example of the present application, is not intended to limit this application.For those skilled in the art
For, various changes and changes are possible in this application.All any modifications made within the spirit and principles of the present application are equal
Replacement, improvement etc., should be included within the scope of the claims of this application.
Claims (15)
1. a kind of preparation method of protein antivirus protection barrier biological agent, comprising:
Step 1: preparing biological nano mesoporous material, including monodimension nanometer material, two-dimension nano materials, porous nanometer material, make
By the processing steps such as raw material preparation, purification, structure and morphology characterization, photocatalysis, stirring extraction when standby, obtain nanometer and inhale
Attached property material；
Step 2: preparation specific binding receptor or ligand, as needed by specific binding receptor recited above or ligand
One of or it is a variety of it is any be mixed and made into solution, solution is made of aqueous solution, weight percent concentration 1-10%；
Step 3: configuration protection filtered fluid, by the solution for the certain proportion concentration that step 1 and step 2 obtain carry out mixing and
Reaction, vacuum distillation obtain protection filtered fluid；
Step 4: production multi-layer film structure medium, is dispersed by solvent casting, semi-solid casting, hot melt extruded (HME), solid
It squeezes or rolling synthesizes in membrane polymer, the partially liq formation film being then added by molding and/or evaporation；
Step 5: preparing protein antivirus protection barrier biological agent, the protection filtered fluid that step 3 is obtained is soaked by room temperature
The two sides of bubble or high pressure painting film made of step 4.
2. the preparation method of protein antivirus protection barrier biological agent according to claim 1, which is characterized in that described
Nano material in step 1 is titania precursor body, is selected from one of tetraethyl titanate, butyl titanate, titanium propanolate or more
Kind；The preparation of nano material includes in hydrothermal/solvent thermal method, sol-gel method, template, method of electrostatic spinning or coprecipitation
It is one or more.
3. the preparation method of protein antivirus protection barrier biological agent according to claim 2, which is characterized in that described
Purification is completed by following steps in step 1:
Step 1.1 takes 0.1g sample lower pretreatment 60 minutes under nitrogen or argon gas (flow 30mL/min) atmosphere, drops naturally
Temperature is to 100 DEG C；
Step 1.2, the Balance Air that NH3-Ar (5%NH3) is passed through into sample are extremely saturated for absorption 60 minutes；
After step 1.3, absorption, with the NH3 of He purging physical absorption；
Step 1.4 is increased to 700 DEG C with the heating rate of 10 DEG C/min, and the ammonia of desorption, which enters gas chromatograph, to carry out online
Analysis determines acid amount and acid strength according to peak area and peak position.
4. the preparation method of protein antivirus protection barrier biological agent according to claim 1, which is characterized in that described
Photocatalysis specifically includes in step 1: the accurate 2L distilled water that measures is packed into reactor, opens constant flow pump, makes the distillation in reactor
Water circulation, opens simultaneously air pump；10mL methylene blue solution is accurately measured again, is placed in reactor, object mixing 10 to be mixed
First sample is taken after minute；It accurately weighs 0.2000g catalyst sample and reactor is added, it is first after absorption is taken after 30 minutes to be adsorbed
Sample.
5. the preparation method of protein antivirus protection barrier biological agent according to claim 1, which is characterized in that described
Step 3 specifically includes:
Different solution is stirred 1-10 hours by step 3.1 according to the proportion, obtains mixed solution；
Alcoholic solution mixing is added into mixed solution for step 3.2, stirs 1-12 hours, obtains the alcohol containing nano-active material point
Dissipate solution；
Step 3.3 carries out sour water solution, sour one in formic acid, acetic acid, ethanedioic acid, hydrochloric acid, nitric acid to alcohol dispersion solution
Kind is a variety of.
6. the preparation method of protein antivirus protection barrier biological agent according to claim 5, which is characterized in that described
The aqueous hydrochloric acid solution that acid solution is 20-40% using concentration.
7. the preparation method of protein antivirus protection barrier biological agent according to claim 4, which is characterized in that described
Ultraviolet lamp is opened after photocatalysis and starts to use manual time-keeping, and a sample was taken every 5 minutes, stops sampling after 3 hours.
8. the preparation method of protein antivirus protection barrier biological agent according to claim 7, which is characterized in that stop
Ultraviolet lamp is opened after sampling and starts to use manual time-keeping, and a sample was taken every 5 minutes, stops sampling after 3 hours.Each sample divides
It is not placed in cuvette through water system film (0.22 μm of aperture) filtering, using distilled water as reference, measurement wavelength is 664nm, is carried out
Absorbance measurement.
9. the preparation method of protein antivirus protection barrier biological agent according to claim 8, which is characterized in that described
The film of step 5 includes multilayered structure, and aperture is sequentially reduced from outside to inside.
10. a kind of protein antivirus protection of the preparation of -9 the methods according to claim 1 obstructs biological agent medium, feature
Be, the medium be the protection filtered fluid configured according to the step 3 be diluted by certain proportion to be formed it is water-soluble
Liquid.
Include the cover of multilayered structure 11. a kind of protein antivirus protection obstructs biological protection filter face mask, from outside to inside according to
Secondary setting filter layer, adsorption layer and secondary filtration layer, filter layer, adsorption layer and secondary filtration layer are impregnated such as claim 10 institute
The protein antivirus protection barrier biological agent medium stated.
12. a kind of protein antivirus protection obstructs biological protection filter screen, it is made of the material of certain pore size, passes through soak at room temperature
Or high-pressure fog protein antivirus protection barrier biological agent medium as claimed in claim 10 is formed.
13. a kind of protein antivirus protection obstructs biological protection filter, including protein as claimed in claim 12 virus
Protection barrier biological protection filter screen, shell, filter tip, air guide port, exhaust outlet and power supply device.
14. a kind of air purifier, including protein antivirus protection as claimed in claim 12 barrier biological protection filter screen,
Motor, fan, intelligent monitor system, external component, filter element, air duct, motor and power supply.
15. a kind of air cleaning fresh air system, including blower, air inlet, exhaust outlet and various pipelines and connector, air inlet are set
It is equipped with protein antivirus protection barrier biological agent filter screen as claimed in claim 12.
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