CN109803951A - 作为cccDNA抑制剂的磺酰胺类化合物 - Google Patents

作为cccDNA抑制剂的磺酰胺类化合物 Download PDF

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Publication number
CN109803951A
CN109803951A CN201780064019.4A CN201780064019A CN109803951A CN 109803951 A CN109803951 A CN 109803951A CN 201780064019 A CN201780064019 A CN 201780064019A CN 109803951 A CN109803951 A CN 109803951A
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compound
alkyl
general formula
halogen
yuan
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CN201780064019.4A
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CN109803951B (zh
Inventor
付志飞
张杨
罗妙荣
陈曙辉
黎健
徐宏江
杨玲
张喜全
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
Medshine Discovery Inc
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

本申请公开了一系列的作为cccDNA抑制剂的由通式(Ⅰ)和通式(Ⅱ)表示的磺酰胺类化合物、其互变异构体或药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (31)

  1. PCT国内申请，权利要求书已公开。
CN201780064019.4A 2016-11-08 2017-11-08 作为cccDNA抑制剂的磺酰胺类化合物 Active CN109803951B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016109797259 2016-11-08
CN201610979725 2016-11-08
PCT/CN2017/109923 WO2018086531A1 (zh) 2016-11-08 2017-11-08 作为cccDNA抑制剂的磺酰胺类化合物

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CN109803951A true CN109803951A (zh) 2019-05-24
CN109803951B CN109803951B (zh) 2020-12-04

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CN (1) CN109803951B (zh)
WO (1) WO2018086531A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020887A (zh) * 2017-06-10 2018-12-18 绍兴从零医药科技有限公司 作为防治精神障碍疾病的酰胺类化合物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970764B (zh) * 2019-03-26 2021-11-09 上海吉奉生物科技有限公司 一种（S）-1,1,5,5-四甲基二氢恶唑并[3,4-c]恶唑-3-酮的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089415A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
CN101842353A (zh) * 2007-08-29 2010-09-22 先灵公司 用于治疗病毒感染的2,3-取代的吲哚衍生物
US20130123266A1 (en) * 2010-07-19 2013-05-16 Vax-Consulting Treatment of a pathology linked to an excessive effect of tnf with a benzene sulphonamide compound
CN104822267A (zh) * 2012-02-29 2015-08-05 巴鲁克·S·布伦博格研究所 乙型肝炎病毒共价闭合环状dna形成的抑制剂及其使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0707558A2 (pt) * 2006-02-08 2011-05-10 Wyeth Corp composto e todas as formas cristalinas e sais farmaceuticamente aceitÁveis dos mesmos, composiÇço farmacÊutica, e, mÉtodo para tratar ou prevenir uma infecÇço de hepatite c em humanos

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089415A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
CN101842353A (zh) * 2007-08-29 2010-09-22 先灵公司 用于治疗病毒感染的2,3-取代的吲哚衍生物
US20130123266A1 (en) * 2010-07-19 2013-05-16 Vax-Consulting Treatment of a pathology linked to an excessive effect of tnf with a benzene sulphonamide compound
CN104822267A (zh) * 2012-02-29 2015-08-05 巴鲁克·S·布伦博格研究所 乙型肝炎病毒共价闭合环状dna形成的抑制剂及其使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020887A (zh) * 2017-06-10 2018-12-18 绍兴从零医药科技有限公司 作为防治精神障碍疾病的酰胺类化合物
CN109020887B (zh) * 2017-06-10 2022-03-01 绍兴从零医药科技有限公司 作为防治精神障碍疾病的酰胺类化合物

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CN109803951B (zh) 2020-12-04
WO2018086531A1 (zh) 2018-05-17

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