CN109793870A - A kind of pure plant essence perfume with antidepression antianxiety - Google Patents
A kind of pure plant essence perfume with antidepression antianxiety Download PDFInfo
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Abstract
The present invention discloses a kind of pure plant essence perfume with antidepression antianxiety, and the perfume is made of the equal following bulk pharmaceutical chemicals of mass parts: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae.The invention also includes the preparation methods of the perfume.Its advantage is shown: 1, using Chinese medicine aromatotherapy, while having treatment and assigning fragrant effect.2, under the guidance of diagnosis and treatment based on an overall analysis of the illness and the patient's condition principle, each herbal medicine of selection all passes through four natures and five flavors of drug, and ascending-aescending-floating-sinking, channel tropism enters internal organs and modern pharmacology research, without any side effects.3, fragrant inhalation is suitable for that overwhelming majority crowd uses.
Description
Technical field
The present invention relates to technical field of Chinese medicine, specifically, being a kind of to have effects that the pure natural of antidepression antianxiety
Plant essence perfume.
Background technique
With society and expanding economy, tempo increase, dog-eat-dog, psychological factor, social factor and the mankind from
Under the influence of the bad behavior and life style of body, various psychosomatic diseases disease incidence in the crowd of all ages and classes constantly rises.According to
Depression caused by the investigation that the World Health Organization announces shows because of emotional stress in the whole world every year there are about 2 to 4 hundred million people,
65% U.S.'s professionals' heart is all that negative feeling is got the upper hand.
Depression refers to depressive symptom group (SelfratingscaleofdepressionDepressivesy in the present invention
Ndrome): it is that primary core symptom is reduced to depressed, slowness of thinking and movement, clinically referred to as three low symptom.Patient
It shows as feeling extremely bad, it is depressed, the external world is reacted slowly, it is blunt to associate, and speech movement is reduced, and feels oneself inferior, certainly
Duty, certainly guilty idea.By current diagnostic classification, it is more common in depression, reactive depression, also sees wound and Poisoning spirit
Obstacle.
Anxiety refers to anxiety symptom in the present invention: based on extensive and lasting sexual anxiety or the terrified uneasiness of recurrent exerbation
Feature is wanted, by current diagnostic classification, is more common in the anxiety disorder (anxietyneurosis) of neurological disorders.
Depression and anxiety are two groups of clinically common symptoms, are mutually indepedent both in current diagnostic classification standard
Entity, and actual clinical work in both usually exist simultaneously, i.e., depression and anxiety comorbidity, refer to patient simultaneously
There are depressive disorders and anxiety disorder, and while being considered respectively two groups of symptoms meets corresponding diagnostic criteria.According to American National
The depressive disorder comorbidity anxiety disorder of comorbidity investigation display 51.2%, 2002 in Spirit of Netherlands sanitary survey and stream
In row disease research, only 39.5% disturbance of emotion and 59.3% anxiety disorder occur in the form of individual, and anxiety
The comorbidity of obstacle and depression is then the most common comorbidity mode.There is anxiety symptom in domestic correlation study document announcement depression
Patient accounts for 67.5%, and the patient for meeting anxiety disorder diagnostic criteria is 50%, and depressive patient and anxiety disorder suffer from rate highest altogether.
At present from Chinese medicine angle, depression and anxiety has been generally acknowledged that " the strongly fragrant disease " for belonging to traditional Chinese medicine, the models such as " palpitaition "
Farmland.And " strongly fragrant disease " has the parting (danxi's experiential therapy six is strongly fragrant) of " six is strongly fragrant ".It falls ill related with constitution and emotional factors.It is distinguished from internal organs
The closest with the relationship of liver for card, next is related to the heart, spleen.Liver dysfunction, the dysfunction of the spleen in transport, the heart become homeless it is feeding, confused and worried, it is dirty
The imbalance of internal organs negative and positive of qi and blood is its main pathogenesis.
For the current treatment of such disease, western medical treatment: various antidepression antianxiety chemical synthetic drugs are for oral administration；Chinese medicine
Treatment: Chinese herbal medicine decoction of medicinal ingredients takes orally and acupuncture and moxibustion therapy.
Aromatotherapy is that dosage form appropriate is made with the plant of fragrant odour to act on whole body or part, with prevent and treat physiology with
Mental disease, a kind of sanatory medical health method.
It is closely bound up that fragrant plant performance drug effect also functions approach.Current most widely used, most study method
It is fragrant inhalation therapy and fragrant Transdermal absorption therapy.Fragrant Transdermal absorption refers to makes aromatic substance very short by massage method
Time in blood circulation (cell tissues such as nerve, bone, muscle can be affected by it) is entered by skin, to reach diseases prevention
The purpose cured the disease.Fragrant inhalation therapy, which then refers to, directly acts on central nervous system by olfactory pathway, while passing through lung,
By gas exchanges, into blood circulation, play the role for the treatment of disease.
As a branch of herbology, aromatotherapy is because the therapeutic effect of its natural quality and natural green is by increasingly
More people are received.This method have the characteristics that letter, just, it is honest and clean, test, it is sufficient to make up the deficiency of decoction of medicinal ingredients for oral administration, can widely apply
In clinical departments.
Aromatotherapy treatment depression and anxiety has the advantage that
1. avoiding Chinese and western drugs takes side reaction orally, it is easy to be received by psychosomatic disease patient；
2. avoid the nociception of acupuncture and moxibustion therapy with it is invasive, be easy to be received by psychosomatic disease patient；
3. especially fragrant inhalation is treated due to directly acting on nervous centralis by olfactory pathway in nervous system disease
In have unique advantage；
4. the effect of the therapeutic effect of its natural quality and natural green " controlling " existing to disease plays the role of " preventing ", easily again
In by receiving popularization and application.
It although aromatotherapy is originating from Europe, is grown up on the basis of traditional medical theory between east and west, application
It is more affected by the influence of west tradition herbology, but the herbal medicine theory in west is limited only to effect and usage, therewith
There is more deep Clinical significance of MG to aromatotherapy compared to the traditional Chinese medicine theories of Chinese materia medica in China.
Perfume is widely used in various occasions by people in modern society, is sprayed on the hem, handkerchief and hairline, the portions such as wrist
Position, distributes pleasant fragrance, is important one of cosmetics, usually and does not have therapeutic effect.
In view of the above problems, the present invention is under the guidance of differentiation of tcm principle, with property of Chinese materia medica theory (four
Gas, the five tastes, channel tropism, ascending-aescending-floating-sinking) selected aromatics Chinese herbal medicine (pure natural fragrant plant), formulate the treatment side of aromatotherapy
Case --- Chinese medicine aromatotherapy.Meanwhile the present invention combines Chinese medicine aromatotherapy with the fragrance sucking of perfume, is keeping fragrant
While water fragrance pleasant characteristic, the antidepression therapeutic effect antianxity of perfume Chinese medicine aromatotherapy of the present invention is assigned, is made
The tax perfume (or spice) effect of existing perfume of the invention is obtained, and has the good psychosomatic disease therapeutic effect of Chinese medicine aromatotherapy, is had significant
Economic benefit and social benefit, have a extensive future.
Summary of the invention
The first purpose of this invention is that in view of the deficiencies of the prior art, providing a kind of has effects that antidepression antianxiety
Chinese medicine composition.
Second object of the present invention is that in view of the deficiencies of the prior art, providing a kind of has effects that antidepression antianxiety
Pure plant essence perfume.
Third object of the present invention is in view of the deficiencies of the prior art, to provide a kind of preparation method of above-mentioned perfume.
To realize above-mentioned first purpose, the technical solution adopted by the present invention is that:
A kind of Chinese medicine composition with antidepression antianxiety, the Chinese medicine composition are equal by following mass parts
Bulk pharmaceutical chemicals are made: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron, the moon
Ji Hua, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, granatum, Pork and beans
Cool, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae.
Preferably, clinically acceptable pharmaceutical preparation is prepared into according to Chinese medicine customary preparation methods.
Preferably, the pharmaceutical preparation is paste, plastics, aerosol, paste, pulvis or emulsion.
To realize above-mentioned second purpose, the technical solution adopted by the present invention is that:
A kind of pure plant essence perfume with antidepression antianxiety, the perfume are equal by following mass parts
Bulk pharmaceutical chemicals be made: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron,
China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, granatum, Pork and beans
Cool, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae.
Preferably, the perfume the preparation method is as follows:
(1) fresh feed medicine: feverfew, wild chrysanthemum, wintercherry fruit or calyx, close illiteracy is taken according to the proportion of the parts by weight such as each bulk pharmaceutical chemicals
Flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, hyacinth bean
Flower, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；By each raw material medicinal powder
It extracts to obtain plants essential oil by steam distillation or organic solvent extraction after broken and mixing；
(2) plants essential oil for taking step (1) to obtain is dissolved as perfume ingredient, and to assign the ratio uniform that fragrant rate is 25%
In the ethanol solution that concentration is 95%, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.
Preferably, the technique of the steam distillation are as follows: take smashed mixed raw material medicine, put it into water vapour steaming
In distillation unit, extracted using steam distillation.
Preferably, the organic solvent extraction is selected from one of the following:
A. take smashed bulk pharmaceutical chemicals, organic solvent be added to medicinal material is just submerged, then using water-bath reflow method into
Row extracts, and extracts 3 times altogether, extracts 1~3h every time, then extracting solution is recovered under reduced pressure after organic solvent under water-bath and obtains plant essence
Oil；
B. take smashed each raw material mixing, and organic solvent be added to medicinal material is just submerged, then using cold-maceration into
Row extracts, and extracts 3 times altogether, extracts 5-7d every time, then extracting solution is recovered under reduced pressure after organic solvent under water-bath and obtains plant essence
Oil.
Preferably, the organic solvent in the organic solvent extraction are as follows: petroleum ether, n-hexane, chloroform, ether or acetic acid
Ethyl ester.
To realize above-mentioned third purpose, the technical solution adopted by the present invention is that:
A kind of preparation method of the pure plant essence perfume with antidepression antianxiety, the preparation of the perfume
Method is as follows:
(1) fresh feed medicine: feverfew, wild chrysanthemum, wintercherry fruit or calyx, close illiteracy is taken according to the proportion of the parts by weight such as each bulk pharmaceutical chemicals
Flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, hyacinth bean
Flower, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；By each raw material medicinal powder
It extracts to obtain plants essential oil by steam distillation or organic solvent extraction after broken and mixing；
(2) plants essential oil for taking step (1) to obtain is dissolved as perfume ingredient, and to assign the ratio uniform that fragrant rate is 25%
In the ethanol solution that concentration is 95%, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.
Preferably, the technique of the steam distillation are as follows: take smashed mixed raw material medicine, put it into water vapour steaming
In distillation unit, extracted using steam distillation；
The organic solvent extraction is selected from one of the following:
A. take smashed bulk pharmaceutical chemicals, organic solvent be added to medicinal material is just submerged, then using water-bath reflow method into
Row extracts, and extracts 3 times altogether, extracts 1-3h every time, then extracting solution is recovered under reduced pressure after organic solvent under water-bath and obtains plant essence
Oil；
B. it takes smashed each raw material to be mixed and added into organic solvent to medicinal material is just submerged, is then carried out using cold-maceration
It extracts, extracts 3 times altogether, extract 5-7d every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution；
Preferably, the organic solvent in the organic solvent extraction are as follows: petroleum ether, n-hexane, chloroform, ether or acetic acid
Ethyl ester.
Preferably, nontoxic Saussurea laniceps flower is selected, toxic snow lotus of big bud flower or Xinjiang Saussurea involucrate or Herba Saussureae Involueratae are disabled.
For depressive symptom anxiety symptom, the present invention uses syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of tri-jiao, differentiation of channels and collaterals system
Determine principle of reatment, selectes aromatics Chinese herbal medicine with the property of Chinese materia medica theoretical (four gas, the five tastes, channel tropism, ascending-aescending-floating-sinking), formulate fragrance
The therapeutic scheme of therapy --- Chinese medicine aromatotherapy.
For depression and anxiety common differential diagnosis in tcm at present, theoretical main threads is many, loses in touching briefly on the essentials, causes disease
Because of interpretation of the cause, onset and process of an illness ambiguity, parting is many and diverse, and only " strongly fragrant disease " just has the parting of " six is strongly fragrant ".And true human five internal organs' six internal organs are integral, and are passed through
Channels and collaterals work hard in glove with connection conduction, internal organs actual situation inside and outside sample relationship in-between in table each other.A certain disease type is it is merely meant that at certain
One internal organs, pathological manifestations are a little prominent in a certain respect, and do not represent remaining internal organs remaining aspect there is no pathologic problems.Therefore
If differentiation of eight principles, the differentiation of tri-jiao, the differentiation of channels and collaterals is started with from syndrome differentiation of zang-fu viscera, under analysis morbid state, three burnt and the five internal organs are in one
The pathological state of cold and heat and asthenia and sthenia in what kind of yin-yang table, then the etiology and pathogenesis of disease can often see the whole picture and a mesh
So.
It is integrally recapitulative dialectical as follows to the Chinese medicine of depression and anxiety:
1. at the part of the body cavity above the diaphragm housing the heart and lungs (mark) --- lung: it is scorching on lung heat, based on lung-fire superinverse；The heart: flaring up of heart fire, the mind disturbance based on, liver:
Liver-fire flaming, based on liver-yang hyperactivity, and perverse and unreasonable manner gram taste, it is weakness of the spleen and the stomach so that liver and gallbladder damp-heat is betted.
2. in middle burnt (sheet) --- taste: weakness of the spleen and the stomach, deficiency-cold in spleen and stomach；Liver and gallbladder: stagnant heat in the liver and gall loses in catharsis；Taste are by wood
Fire multiplies, and phlegm wet extravasated blood is stagnated.
3. in lower burnt (sheet) --- kidney: yang-energy, which loses, is lost in storage, and the mistake of the nephrons cold of insufficiency type in taking the photograph admittedly；Liver kidney: liver-kidney deficiency, liver
Kidney deficiency；Water-wet and liver and gallbladder damp-heat bet.
Wherein part of the body cavity above the diaphragm housing the heart and lungs disease is often the mark of disease, and the sheet of its disease descends two cokes in really: lung-fire superinverse is mark, spleen
Stomach weakness is this；Flaring up of heart fire, mind disturbance is mark, water-fire imbalance, and the insufficiency of the kidney yang is this；Liver-fire flaming liver-yang hyperactivity is mark,
Kidney deficiency and liver, nephrons loss, water files to nourish wood for this；Phlegm wet extravasated blood is mark, and liver depression hyperactivity of fire is weakness of the spleen and the stomach, and wood fire gram soil, transporting is lost
Department is this；So based on the part of the body cavity above the diaphragm housing the heart and lungs temporary solution, based on lower two cokes effect a permanent cure in.
Fang Xie: be based on syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of channels and collaterals, the differentiation of tri-jiao:
The part of the body cavity above the diaphragm housing the heart and lungs: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia；
Middle coke: orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos；
Lower coke: cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, granatum, Schisandra chinensis, nutmeg, psoralea corylifolia, fructus alpiniae oxyphyllae.This
Square principle of reatment:
In the part of the body cavity above the diaphragm housing the heart and lungs, conscience lung --- -- clearing away the heart-fire, tranquilizing mind；Pancake irascibility, drop of diving liver-yang；Clearing lung-heat fire, respectful drop lung heat.With
Clearly, with drop, based on peace, based on temporary solution.
In middle coke, taste --- -- warm temperature supports taste, soothing liver-qi stagnation, activating microcirculation and removing stasis medicinal resolving sputum.With Wen Yangwenization, with transporting
Based on dredging, based on effecting a permanent cure.
In lower coke, liver kidney --- -- temperature compensation nephrons tonifies the liver and kidney, gas of receiving holds back mind；It fills up deficit and damages tonifying for the deficiency, guiding fire to origin；In temperature
On the basis of warming spleen and stomach, dispel damp and hot.Based on effecting a permanent cure.
Contraindication: pregnant woman and specific anaphylactogen allergic human population is used with caution.
The present invention is directed to depression and anxiety symptom, and with syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of tri-jiao, differentiation of channels and collaterals formulation controlled
Principle is treated, aromatics Chinese herbal medicine is selected with the property of Chinese materia medica theoretical (four gas, the five tastes, channel tropism, ascending-aescending-floating-sinking), formulates aromatotherapy
Therapeutic scheme --- Chinese medicine aromatotherapy.The Chinese medicine aromatotherapy includes fragrant inhalation and Transdermal absorption method.
The invention has the advantages that:
1, it is provided simultaneously with therapeutic effect and assigns fragrant effect, wide application: when as a kind of Chinese medicine aromatotherapy, have good
Good psychosomatic disease therapeutic effect；When as a kind of pure plant essence perfume, and there is the fragrant effect of good tax.
2, the present invention chooses pure natural aromatics flowers and aromatics plant carries out composition of prescription, without containing any artificial
Synthetic ingredient, dual-purpose of drug and food, safety are without side-effects.
3, under the guidance of diagnosis and treatment based on an overall analysis of the illness and the patient's condition principle, syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of channels and collaterals, the differentiation of tri-jiao, selected is every
Bulk pharmaceutical chemicals simply, all pass through four natures and five flavors of drug, ascending-aescending-floating-sinking, and channel tropism enters internal organs and modern pharmacology research, only has to human body excellent
Good positive effect, and it is without any side effects, and curative effect is good.
4, using fragrant inhalation, it is suitable for that overwhelming majority crowd uses, improves the acceptance of patient.
5, our tonifying spleen and stomach clearing lung-heat heat is with reinforcing earth to generate metal；Calming the liver is soothing the liver, the feeding taste of temperature, to help soil suppression wood, activating microcirculation and removing stasis medicinal, reason
Gasify phlegm；Kidney tonifying drops internal heat with restoring normal coordination between heart and kidney, and guiding fire to origin restrains floating sun, and gas of receiving is calmed the nerves；Realize treating both manifestation and root cause of disease.
6, we are cured mainly based on the property of Chinese materia medica theoretical (four natures and five flavors of drug, ascending-aescending-floating-sinking, channel tropism enter internal organs) and efficacy of drugs
For principle composition of prescription, for upward, the yang-energy dissipated to export-oriented table is to be reduced to master, based on heavy, based on receiving；In the part of the body cavity above the diaphragm housing the heart and lungs,
Internal heat, Pinggan Yang, respectful drop lung heat drop；Lower two burnt, warmly invigorating spleen and stomaches, temperature compensation nephrons tonify the liver and kidney to restrain to take the photograph and receive, ignite and return in
Member, both help extreme misery.
7, the bulk pharmaceutical chemicals chosen in we are based on flowers class, fruit and seed class drug, dual-purpose of drug and food, and safety is made without pair
With.
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after having read the content of the invention recorded, art technology
Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Fixed range.
A kind of Chinese medicine composition with antidepression antianxiety of embodiment 1
Bulk pharmaceutical chemicals are taken according to parts by weight equivalent proportion: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus
Flower, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, continuous head snow
Lotus flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae.
A kind of paste with antidepression antianxiety of embodiment 2
Bulk pharmaceutical chemicals are taken according to parts by weight equivalent proportion: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus
Flower, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, continuous head snow
Lotus flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；By each bulk pharmaceutical chemicals with paste adjuvant according to normal
The paste with antidepression antianxiety is prepared in regulation prescription method.
A kind of perfume (one) with antidepression antianxiety of embodiment 3
The preparation method is as follows:
(1) each fresh feed medicine that parts by weight are equal: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus is taken
Flower, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, continuous head snow
Lotus flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；It is placed after each bulk pharmaceutical chemicals are crushed and mixed
In steam distillation apparatus, extract to obtain plants essential oil using organic solvent extraction；
(2) plants essential oil for taking step (1) to obtain is dissolved as perfume ingredient, and to assign the ratio uniform that fragrant rate is 25%
In the ethanol solution that concentration is 95%, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.It is protected from light and is sealed in case using.
A kind of perfume (two) with antidepression antianxiety of embodiment 4
The preparation method is as follows:
(1) each fresh feed medicine that parts by weight are equal: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus is taken
Flower, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, continuous head snow
Lotus flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；It is added after each bulk pharmaceutical chemicals are crushed and mixed
Then petroleum ether is extracted to medicinal material is just submerged using water-bath reflow method, extract altogether 3 times, extracts 1~3h every time, then
Plants essential oil is obtained after organic solvent is recovered under reduced pressure under water-bath in extracting solution；
(2) plants essential oil for taking step (1) to obtain is dissolved in as perfume ingredient, and to assign the ratio uniform of fragrant rate 25%
In the ethanol solution that concentration is 95%, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.It is protected from light and is sealed in case using.
A kind of perfume (three) with antidepression antianxiety of embodiment 5
The preparation method is as follows:
(1) each fresh feed medicine that parts by weight are equal: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, lotus is taken
Flower, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, continuous head snow
Lotus flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；Each raw material is pulverized and mixed and ether is added
It to medicinal material is just submerged, is then extracted using cold-maceration, extracts 3 times altogether, extract 5-7d every time, then by extracting solution in water-bath
Under organic solvent is recovered under reduced pressure after obtain vegetable oil；
(2) plants essential oil for taking step (1) to obtain is dissolved in as perfume ingredient, and to assign the ratio uniform of fragrant rate 25%
In 95% ethanol solution, the parts by weight of the ethanol solution are 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.It is protected from light and is sealed in case using.
Embodiment 6 has effects that the sensory evaluation of the perfume of antidepression antianxiety
One, clinical data
(20-30 years old, wherein each 10 of men and women, had perfume sense organ and comment 20 persons of participating in the experiment of Attached Tongji Hospital, Tongji Univ.
The rudimentary knowledge divided) composition scoring group.
Two, experimental method
The perfume that 20 persons of participating in the experiment at room temperature are prepared embodiment 3,4,5 is evaluated, its average value is taken.It is thin
Then referring to perfume comprehensive score standard and detailed rules and regulations in table 1.Standards of grading are pure and fresh unique point (30 points)；Coordinate mellow and full point (30
Point)；Fragrance persistently divides (40 points).
Three, experimental result
The situation that scores is as follows:
Table 1
Four, experiment conclusion
It is above-mentioned the results showed that by using the perfume that bulk pharmaceutical chemicals and preparation method of the invention obtain, have pure and fresh
Advantage that is unique, coordinating mellow and full odor prolongation length.
Embodiment 7 has effects that the effect of perfume of antidepression antianxiety is evaluated
One, data
1, general information
It chooses 2 months -2018 years 2 months 2016 and goes to a doctor patient 210 in Attached Tongji Hospital, Tongji Univ., male 100, female
110, average age (33.24 ± 11.58) year, it is minimum 20 years old, 50 years old maximum；It is average course of disease (8.6 ± 5.7) moon, most 6 short
Month, longest 18 months.All patients are to product of the invention not allergy, and selected patient meets CCMD-3 and DSM-IV is extensive
Sexual anxiety disease diagnostic criteria, score >=18 manifest anxiety scale (HAMARS), no physical disease and brain organic disease, using random number
Word table method is divided into four groups, one group, two groups for the treatment of, treatment three groups, control group is respectively treated, in property before four groups of patient's treatments
Not, age, the course of disease etc., there was no significant difference, and balance between the two groups is good, is comparable.
2, diagnostic criteria
Selected patient meets CCMD-3 and DSM-IV generalized anxiety disorder diagnostic criteria, manifest anxiety scale (HAMARS) score
≥18。
3, it is included in standard
(1) meet above-mentioned diagnostic criteria；
(2) age, men and women was unlimited between 20-50 years old.
(3) subject signs informed consent form.
4, standard is rejected:
The case for not meeting the standard of being included in and being accidentally included in；Though not controlled with this research approach after meeting the standard of being included in and being included in
The case for the treatment of；Non- curative effect reason and adverse reaction and test midway stop the case that falls off；Add with other drugs person；Data is not complete
It cannot the person of statistics.
1.5 terminate and remove clinical test standard: other diseases occur in test, influence to test into passerby；It can not be pre-
Other situations seen.
Two, method
1, treatment method: the perfume that embodiment 3 is prepared is given in one group for the treatment of, and patient uses fragrant inhalation medication,
Each dosage is 10-12ml, daily times for spraying 2-4 times, medication 8 weeks.
Treat two groups and give following therapeutic scheme: taking fresh feed medicine: feverfew 20g, wild chrysanthemum 20g, wintercherry fruit or calyx 20g,
Butterflybush flower 20g, Chinese trumpet creeper 20g, Flos Hibisci Mutabilis 20g, camellia 20g, orange peel 40g, fingered citron 40g, citron 40g, China rose 40g, drop
Fragrant 40g, inular flower 40g, Flos Magnoliae Officinalis 40g, bitter orange flower 40g, flower of hyacinth dolichos 40g, cortex cinnamomi 60g, Saussurea laniceps flower 60g, cloves 60g,
Each bulk pharmaceutical chemicals are crushed and are mixed by fructus amomi 60g, granatum 60g, nutmeg 60g, Schisandra chinensis 60g, psoralea corylifolia 60g, fructus alpiniae oxyphyllae 60g
Petroleum ether is added after conjunction to medicinal material is just submerged, is then extracted using water-bath reflow method, is extracted 3 times altogether, extracted every time
1-3h, then plants essential oil is obtained after organic solvent is recovered under reduced pressure under water-bath in extracting solution；Using obtained plants essential oil as perfume
Smart ingredient, and be dissolved in 95% ethanol solution with assigning the ratio uniform of fragrant rate 25%, the parts by weight of the ethanol solution
It is 20 times of vegetable oil parts by weight；Obtained solution is filtered, perfume is obtained.By the perfume to patient medication, administrated method
For fragrant inhalation, each dosage is 10-12ml, daily times for spraying 2-4 times, medication 8 weeks.
It treats three groups and gives following therapeutic scheme: removing column fresh feed medicine: orange peel, Buddhist according to parts by weight equivalent proportion
Hand, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, cortex cinnamomi, cloves, fructus amomi, nutmeg, Schisandra chinensis, psoralea corylifolia,
Each raw material is pulverized and mixed and ether is added to medicinal material is just submerged, then extracted using cold-maceration, extracted altogether by fructus alpiniae oxyphyllae
3 times, 5-7d is extracted every time, then obtain vegetable oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution；The plant that will be obtained
Essential oil is dissolved in 95% ethanol solution as perfume ingredient, and to assign the ratio uniform of fragrant rate 25%, the ethanol solution
Parts by weight be 20 times of vegetable oil parts by weight；Obtained solution is filtered, perfume is obtained.The perfume uses patient
Medicine, administrated method are fragrant inhalation, and each dosage is 10-12ml, daily times for spraying 2-4 times, medication 8 weeks.
Control group gives following therapeutic scheme: buspirone (5mg/ piece) group, first week daily 10-12mg take in three times.
The 2-8 weeks daily 15mg, takes in three times, and two groups of courses for the treatment of are 8 weeks.
2, standards of grading
Curative effect evaluation clinical efficacy is evaluated by China existing " mental disease efficacy assessment standard ", evaluation criteria point four
Grade: recovery from illness (mental symptom completely disappears), it is effective (cardinal symptom disappearance), effectively (symptom mitigates or partial disappearance), invalid (disease
Shape without improve or aggravate), treatment before and treatment after (the 8th week) respectively evaluation once.It is evaluated by three psychiatric department doctors with long years of standing and rich experience.
Blood, routine urinalysis, liver function, kidney function, blood glucose, electrocardiogram, electroencephalogram, weight, blood pressure determination control are carried out at pre-treatment and after treatment.
3, statistical analysis total data is analyzed with SPSS11.0 software, is indicated with mean+SD (x ± s).Group
Between difference one-way analysis of variance, curative effect Chi-square Test.
Three, result
1, each group curative effect is shown in Table 2.
Curative effect after 2 each group medication of table 8 weeks
| Treat one group | Treat two groups | Treat three groups | Control group | |
| Number of cases | 51 | 52 | 54 | 53 |
| Recovery from illness | 28 | 27 | 25 | 20 |
| It is effective | 14 | 14 | 13 | 12 |
| Effectively | 7 | 6 | 6 | 5 |
| In vain | 2 | 5 | 10 | 16 |
| Total effective rate (%) | 96.08 | 90.38 | 81.48 | 69.81 |
2, each group adverse reaction is relatively shown in Table 3.
Adverse reaction after 3 each group medication of table 8 weeks
| Treat one group | Treat two groups | Treat three groups | Control group | |
| Number of cases | 51 | 52 | 54 | 53 |
| It is dizzy | 1 (1.96%) | 1 (1.92%) | 2 (3.70%) | 7 (13.21%) |
| It is out of strength | 0 | 2 (3.85%) | 3 (5.56%) | 6 (11.32%) |
| Dry | 0 | 1 (1.92%) | 1 (1.85%) | 1 (1.89%) |
| Nausea | 1 (1.96%) | 1 (1.92%) | 1 (1.85%) | 2 (3.77%) |
| It is total | 2 (3.92%) | 5 (9.61%) | 87 (12.96%) | 16 (30.19%) |
Four, conclusion
It is above-mentioned to be better than treating two groups the results showed that treating one group of effect, illustrate the Chinese medicine composition of we certain
Ratio range in, have the advantages that antidepression, anxiolytic effect are significant, treat one group of effect better than two groups for the treatment of, illustrate this
Feverfew, wild chrysanthemum, butterflybush flower, wintercherry fruit or calyx, Flos Hibisci Mutabilis, camellia, Chinese trumpet creeper, flower of hyacinth dolichos, Saussurea laniceps flower, granatum in side
It is used with other Chinese traditional medicine compositions, significantly improves antianxiety, helps sleeper effect.
For depressive symptom anxiety symptom, the present invention uses syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of tri-jiao, differentiation of channels and collaterals system
Determine principle of reatment, selectes aromatics Chinese herbal medicine with the property of Chinese materia medica theoretical (four gas, the five tastes, channel tropism, ascending-aescending-floating-sinking), formulate fragrance
The therapeutic scheme of therapy --- Chinese medicine aromatotherapy.The result shows that: the perfume curative effect that the present invention is prepared is good, and adverse reaction is small.
The present invention is under the guidance of diagnosis and treatment based on an overall analysis of the illness and the patient's condition principle, syndrome differentiation of zang-fu viscera, differentiation of eight principles, the differentiation of channels and collaterals, and the differentiation of tri-jiao is selected
Per bulk pharmaceutical chemicals simply, all pass through four natures and five flavors of drug, ascending-aescending-floating-sinking, channel tropism enters internal organs and modern pharmacology research, only to human body
There is excellent positive effect, without any side effects, patient restores fast using the rear state of an illness, and curative effect is good；And with mostly adopt in the prior art
With Chinese herbal medicine is for oral administration or the administration mode of decoction or oral western medicine compares, the present invention uses Chinese medicine aromatotherapy, substantially increases
Patient acceptance is provided simultaneously with tax perfume and therapeutic efficiency, has very strong practicability.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, without departing from the principle of the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition with antidepression antianxiety, which is characterized in that the Chinese medicine composition is by following matter
The equal bulk pharmaceutical chemicals of amount part are made: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel, Buddhist
Hand, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi, stone
Pomegranate skin, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae.
2. Chinese medicine composition according to claim 1, which is characterized in that be prepared into clinic according to Chinese medicine customary preparation methods
Upper acceptable pharmaceutical preparation.
3. Chinese medicine composition according to claim 2, which is characterized in that the pharmaceutical preparation is paste, aerosol, paste
Agent, pulvis or emulsion.
4. a kind of pure plant essence perfume with antidepression antianxiety, which is characterized in that the perfume is by following
The equal bulk pharmaceutical chemicals of mass parts are made: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, Chinese trumpet creeper, Flos Hibisci Mutabilis, camellia, orange peel,
Fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, cortex cinnamomi, Saussurea laniceps flower, cloves, fructus amomi,
Granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae.
5. pure plant essence perfume according to claim 4, which is characterized in that the preparation method of the perfume is such as
Under:
(1) fresh feed medicine: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, icepro is taken according to the proportion of the parts by weight such as each bulk pharmaceutical chemicals
Clouds flower, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, meat
Osmanthus, Saussurea laniceps flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；Each bulk pharmaceutical chemicals are crushed and mixed
It extracts to obtain plants essential oil by steam distillation or organic solvent extraction after conjunction；
(2) plants essential oil for taking step (1) to obtain as perfume ingredient, and with assign the ratio uniform that fragrant rate is 25% be dissolved in it is dense
Degree is in 95% ethanol solution, the parts by weight of the ethanol solution is 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.
6. pure plant essence perfume according to claim 5, which is characterized in that the technique of the steam distillation
Are as follows: smashed mixed raw material medicine is taken, puts it into steam distillation apparatus, is extracted using steam distillation.
7. pure plant essence perfume according to claim 5, which is characterized in that the organic solvent extraction is selected from
One of the following:
A. smashed bulk pharmaceutical chemicals are taken, organic solvent is added to medicinal material is just submerged, is then mentioned using water-bath reflow method
It takes, extracts 3 times altogether, extract 1-3h every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution；
B. smashed each raw material mixing is taken, and organic solvent is added to medicinal material is just submerged, is then mentioned using cold-maceration
It takes, extracts 3 times altogether, extract 5-7d every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution.
8. pure plant essence perfume according to claim 5, which is characterized in that in the organic solvent extraction
Organic solvent are as follows: petroleum ether, n-hexane, chloroform, ether or ethyl acetate.
9. a kind of preparation method of the pure plant essence perfume with antidepression antianxiety, which is characterized in that described
Perfume the preparation method is as follows:
(1) fresh feed medicine: feverfew, wild chrysanthemum, wintercherry fruit or calyx, butterflybush flower, icepro is taken according to the proportion of the parts by weight such as each bulk pharmaceutical chemicals
Clouds flower, Flos Hibisci Mutabilis, camellia, orange peel, fingered citron, citron, China rose, dalbergia wood, inular flower, Flos Magnoliae Officinalis, bitter orange flower, flower of hyacinth dolichos, meat
Osmanthus, Saussurea laniceps flower, cloves, fructus amomi, granatum, nutmeg, Schisandra chinensis, psoralea corylifolia, fructus alpiniae oxyphyllae；Each bulk pharmaceutical chemicals are crushed and mixed
It extracts to obtain plants essential oil by steam distillation or organic solvent extraction after conjunction；
(2) plants essential oil for taking step (1) to obtain as perfume ingredient, and with assign the ratio uniform that fragrant rate is 25% be dissolved in it is dense
Degree is in 95% ethanol solution, the parts by weight of the ethanol solution is 20 times of vegetable oil parts by weight；
(3) solution for obtaining step (2) filters, and obtains perfume.
10. preparation method according to claim 9, which is characterized in that the technique of the steam distillation are as follows: after taking crushing
Mixed raw material medicine, put it into steam distillation apparatus, extracted using steam distillation；
The organic solvent extraction is selected from one of the following:
A. smashed bulk pharmaceutical chemicals are taken, organic solvent is added to medicinal material is just submerged, is then mentioned using water-bath reflow method
It takes, extracts 3 times altogether, extract 1-3h every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution；
B. it takes smashed each raw material to be mixed and added into organic solvent to medicinal material is just submerged, is then mentioned using cold-maceration
It takes, extracts 3 times altogether, extract 5-7d every time, then obtain plants essential oil after organic solvent is recovered under reduced pressure under water-bath in extracting solution；
Organic solvent in the organic solvent extraction are as follows: petroleum ether, n-hexane, chloroform, ether or ethyl acetate.
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| CN110123981A (en) * | 2019-05-27 | 2019-08-16 | 上海市同济医院 | A kind of Chinese medicine aromatotherapy composition and its application for having effects that intelligence promoting and tranquilization and helping sleep |
| CN112451575A (en) * | 2020-08-21 | 2021-03-09 | 上海中医药大学 | Aromatic vegetable oil for five seasons |
| CN114053348A (en) * | 2021-11-26 | 2022-02-18 | 江西中医药大学 | Application of citron in preparation of product for preventing and treating anxiety disorder |
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| CN1500477A (en) * | 2002-11-13 | 2004-06-02 | 丛繁滋 | Quick result aerosol with plant aroma and its preparation |
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| CN112451575A (en) * | 2020-08-21 | 2021-03-09 | 上海中医药大学 | Aromatic vegetable oil for five seasons |
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Application publication date: 20190524 |