CN109778132A - A kind of Cu/Zn injects the preparation method and application of TiN package titanium alloy altogether - Google Patents
A kind of Cu/Zn injects the preparation method and application of TiN package titanium alloy altogether Download PDFInfo
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Abstract
The present invention provides a kind of copper (Cu) ion, zinc (Zn) ion inject altogether TiN package titanium alloy preparation method and its applied in terms of extending bone planting body service life.The method is characterized in that using plasma immersion ion injection technique (PIII) deposits one layer of titanium nitride (TiN) in titanium alloy surface in advance, Cu, Zn ion are then injected on its surface by PIII technology altogether.This method can effectively improve the hardness and wearability of medical titanium alloy, and collaboration improves the cell compatibility and antibiotic property of titanium alloy, inhibits the release of toxic ion in titanium alloy, achieve the purpose that extend the titanium alloy implant materials'use service life.
Description
Technical field
The present invention relates to the preparation methods that a kind of Cu/Zn injects the titanium alloy of TiN package altogether, and its are extending orthopaedics plantation
Application in terms of body service life.
Background technique
Titanium alloy is the common used material in current orthopedic medical device field, has good biocompatibility, density is light, springform
Measure low, the good advantage of corrosion resisting property.But the defects of its hardness is lower, and anti-shearing and wear resistance is poor, and antibiotic property is poor, causes
Using titanium alloy easily to be ground after fixing product implantation in the wounds such as the joint prosthesis of substrate, bone-fracture fixation steel plate, screw, Invasive lumbar fusion device
Damage, organizes the formation of the thick object of dark brown in periarticular, causes pain；It tends to have and releases V, Al element, induce cancer and old age is silly
Slow-witted disease.It is modified therefore, it is necessary to carry out surface to medical titanium alloy, retains its mechanics and biological superiority, its clinic is overcome to lack
It falls into.
Plasma immersion and ion implantation is as a kind of new surface modifications technology quickly grown in recent years, generally in height
It is carried out under vacuum condition, is a kind of pollution-free, environmentally friendly surface modifying method.It can retain the original physicochemical property of titanium alloy,
Titanium alloy surface film forming, injection modified ion improve its hardness, wear-resisting to change titanium alloy surface biology and physical property
Property, antibiotic property etc..
The present invention provides the preparation method that a kind of Cu/Zn hybrid ionic injects the titanium alloy of TiN package altogether.This method is to adopt
One layer of titanium nitride (TiN) film is deposited in titanium alloy surface with plasma immersion ion implantation technique (PIII).TiN is as one
The kind good ganoine thin film of biological property, on the one hand being coated on titanium alloy surface can be improved its abrasion resistance and hardness；Another party
Face can inhibit the release of the poison such as Al, V ion in titanium alloy.Then, then by PIII by Cu and Zn hybrid ionic package is injected altogether
Layer --- in TiN coating.Copper is as a kind of antibacterial agent, and toxicity is low compared with other anti-biotic materials, it is not only a kind of required
Microelement, be the catalyst of a variety of enzymes, can participate in metabolism；Importantly, copper can also prevent bacterium from forming protectiveness
Biomembrane can destroy the cell wall and cell membrane of bacterium strongly, prevent bacterial reproduction.Composition of the zinc as a variety of enzymes and protein
Part can promote the proliferation and differentiation and the essential trace elements of the human body of cell, rise emphatically in the growth and development of the mankind
The effect wanted.The injection modification of Cu/Zn hybrid ionic can cooperate with the cell compatibility and antibiotic property for promoting titanium alloy.In conclusion
Cu/Zn injects the titanium alloy material of TiN package altogether, has that hardness is high, wearability is strong, cell compatibility compared with conventional medical titanium alloy
Well, the good advantage of antibiotic property can effectively extend the clinical use service life of conventional medical titanium alloy as orthopaedics implant material.
Summary of the invention
The present invention relates to a kind of titanium alloys for injecting surface package titanium nitride membrane altogether using copper (Cu), zinc (Zn) ion
(TiN-Ti-6Al-4V), to reach the method for extending titanium alloy service life in orthopaedics planting body.Firstly, using plasma
Body immersion ion injection technique (PIII) prepares one layer of titanium nitride (TiN) film on the titanium alloy surface (Ti-6Al-4V)；Then again
Cu ion and Zn ion are infused in TiN-Ti-6Al-4V altogether by PIII, surface is prepared and contains Cu, Zn mixing modification
The titanium alloy material (Cu/Zn-TiN-Ti-6Al-4V) of TiAlN thin film package.The material can inhibit releasing for titanium alloy poisoning ion
It puts, there is hardness, wearability, antibiotic property and the cell compatibility better than medical titanium alloy, titanium alloy can be extended and planted in orthopaedics
Service life in body.
To achieve the above object, the invention discloses following technology contents:
A kind of Cu/Zn injects the preparation method of TiN package titanium alloy altogether, it is characterised in that carries out by following step:
(1) by 10 mm of diameter, the titanium alloy of thickness 2mm uses distilled water, dehydrated alcohol and acetone soln ultrasonic cleaning respectively, instead
Multiple cleaning is several times；
(2) titanium alloy after cleaning in step (1) is put into vacuum chamber, when matrix pressure reaches 10-5-10-7When high vacuum,
Under 400-500V bias, titanium alloy 10-20min is cleaned with argon ion；
(3) after the completion of step (2), flowmeter is opened, makes the flow of argon gas and nitrogen 3:1-9:1 ratio by volume, is opened straight
Arc source is flowed, titanium target (99.99%) 5-180min is sputtered in the atmosphere of argon gas and nitrogen, titanium ion is in conjunction with Nitrogen ion in vacuum
TiN is formed, is deposited on titanium alloy surface, TiN coating is up to nanometer to micron level (500nm-2 μm)；
(4) after the completion of step (3), nitrogen is closed, argon gas is turned down 3-15sccm flow, in the feelings for opening negative -10--30kV high pressure
Under condition, opens two pulsed arc sources while ionizing fine copper target and pure zinc target 10-120min, the copper ion of ionization and zinc ion are total to
It is injected into the titanium alloy of titanium nitride package, obtains the titanium alloy sample Cu/Zn-TiN-Ti-6Al- containing copper, zinc ion
4V；The copper ion step-by-step counting range is 1800-5400, and zinc ion step-by-step counting range is 1800-5400.Wherein deposit
Time is 5-180 minutes, when copper, zinc ion inject altogether, and injection length is 10-120 minutes altogether.
The present invention further discloses the Cu/Zn- for the preparation method preparation for injecting TiN package titanium alloy altogether using Cu/Zn
Application of the TiN-Ti-6Al-4V in terms of extending orthopaedics titanium alloy implant service life, experimental result are shown: (Cu/ after injection
Zn-TiN-PIII the hardness compared with common medical titanium alloy of sample) is higher, wearability is more preferable, and from hydrophilicity experiment, egg
From the point of view of the experiments such as white electrophoresis experiment, In vitro cell experiment and in-vitro antibacterial, the titanium alloy material after injection has excellent mechanics
Performance and biology performance are expected to extend the service life of medical titanium alloy.
Cu/Zn disclosed by the invention injects TiN package titanium alloy preparation method possessed product compared with prior art altogether
Pole effect is:
(1) ion implanting is a kind of new surface modifications technology quickly grown nearly ten years, its not only cleanliness without any pollution, environment
Close friend, and it is able to maintain the original performance of matrix, size and surface smoothness again；
(2) hardness and wear-resisting property that transition zone improves titanium alloy are done with titanium nitride；
(3) Cu/Zn ion injects the inoxidizability that can make material, corrosion resistance, fatigue durability, antibiotic property, cell compatibility altogether
Deng generation significant changes, it is expected to improve the performance and used life of titanium alloy.
(4) Cu/Zn disclosed by the invention inject altogether TiN package titanium alloy material preparation method it is easy to operate, do not have
Pollution, practical, high-efficient, film layer is stable and injection ion distribution is uniform, further enriches and developed medical titanium alloy
Performance and used life.
Present invention mainly solves titanium alloys as the clinical shortcomings such as easy to wear existing for orthopaedics implant, easy infection, weight
Point investigated Cu/Zn ion inject altogether TiN package titanium alloy after, the mechanical property and biology performance of titanium alloy, main difficulty
Point is to find content and ratio with Cu/Zn ion implanting in most excellent properties titanium alloy.
Detailed description of the invention
Fig. 1 is the hardness line chart of the titanium alloy sample (Cu/Zn-TiN-PIII) and preflood titanium alloy after injection；
Fig. 2 be injection after titanium alloy sample (Cu/Zn-TiN-PIII) and preflood titanium alloy (TiN-PIII) to protein
Absorption figure；
Fig. 3 is the titanium alloy sample (Cu/Zn-TiN-PIII) and preflood titanium alloy (TiN-PIII) superficial cell after injection
OD value with incubation time variation the case where；
Fig. 4 is that the surface of the titanium alloy sample (Cu/Zn-TiN-PIII) and preflood titanium alloy (TiN-PIII) after injection is thin
Born of the same parents' shape appearance figure；
Fig. 5 be injection after titanium alloy sample (Cu/Zn-TiN-PIII) and the surface preflood titanium alloy (TiN-PIII) resist
Bacterium effect picture and sample antibiotic rate.
Specific embodiment
Specific embodiments of the present invention are given below, it should be noted that the invention is not limited to implement in detail below
Example, all equivalent transformations made on the basis of the technical solutions of the present application each fall within protection scope of the present invention.In following embodiments
Experimental method is unless otherwise specified conventional method.Test material as used in the following examples is commodity or self-control,
Unless otherwise specified, default reagent is commercially available for shop.
Embodiment 1
Taking 30 diameters is 10 mm, and the titanium alloy of thickness 2mm uses distilled water, dehydrated alcohol and acetone soln ultrasonic cleaning respectively
15 min.Titanium alloy after cleaning is put into vacuum chamber, when matrix pressure reaches 4.0 × 10-4When pa, in the bias of 500 V
Under, 15 min of titanium alloy is cleaned with argon ion.Firstly, deposited TiAlN thin film in titanium alloy surface.Flowmeter is opened, argon gas is made
Flow with nitrogen is respectively 18 sccm and 6 sccm.DC arc source is opened, sputters titanium target in the atmosphere of argon gas and nitrogen
(99.99%), titanium ion forms TiN in conjunction with Nitrogen ion in vacuum, is deposited on titanium alloy surface.In the process, operating pressure
About 8.4 × 10-2Pa, sedimentation time are 60 min, and TiN coating layer thickness is about 700nm.Nitrogen is closed, argon flow is adjusted to
10 sccm.In the case where negative high voltage are -15 kV, two pulsed arc sources are opened, makes it while ionizing fine copper target and pure 30 min of zinc target,
The copper ion of ionization and zinc ion are injected into altogether in the titanium alloy of titanium nitride package, it obtains the titanium containing copper, zinc ion and closes
Golden sample Cu/Zn-TiN-Ti-6Al-4V；The copper ion step-by-step counting is 1798, and zinc ion step-by-step counting is 1519.Its
Middle sedimentation time is 60 minutes, when copper, zinc ion inject altogether, and injection length is 30 minutes altogether.By sample obtained, carry out external
Cell experiment and antibacterial experiment look at the growing state of cell and bacterium, and the service performance of titanium alloy sample is measured with this.
Embodiment 2
A kind of Cu/Zn injects the preparation method of TiN package titanium alloy altogether:
(1) by 10 mm of diameter, the titanium alloy of thickness 2mm uses distilled water, dehydrated alcohol and acetone soln ultrasonic cleaning respectively, instead
It cleans 3 times again；
(2) titanium alloy after cleaning in step (1) is put into vacuum chamber, when matrix pressure reaches 10-5When high vacuum, 400
Under bias, titanium alloy 15min is cleaned with argon ion；
(3) after the completion of step (2), flowmeter is opened, makes the flow of argon gas and nitrogen 7:1 ratio by volume, opens DC arc
Source sputters titanium target (99.99%) 120min in the atmosphere of argon gas and nitrogen, and titanium ion is formed in conjunction with Nitrogen ion in vacuum
TiN is deposited on titanium alloy surface, and TiN coating layer thickness is up to 1.2 μm.
(4) after the completion of step (3), nitrogen is closed, argon gas is turned down 12sccm flow, the case where opening negative -10kV high pressure
Under, it opens two pulsed arc sources while ionizing fine copper target and pure zinc target 60min, the copper ion of ionization and zinc ion are injected into altogether
In the titanium alloy of titanium nitride package, the titanium alloy sample Cu/Zn-TiN-Ti-6Al-4V containing copper, zinc ion is obtained；It is described
Copper ion step-by-step counting be 3600, zinc ion step-by-step counting be 3578.Wherein sedimentation time is 120 minutes, and copper, zinc ion are total
When injection, injection length is 60 minutes altogether.
Embodiment 3
The Cu/Zn of preparation injects the actual use situation (extending bone planting body service life) of TiN package titanium alloy altogether:
(1) taking 30 diameters is 10 mm, and the titanium alloy of thickness 2mm uses distilled water, dehydrated alcohol and acetone soln ultrasound clear respectively
It washes 3 times.Titanium alloy after cleaning is put into vacuum chamber, when matrix pressure reaches 5.0 × 10-4When pa, in the bias of 450 V
Under, 20 min of titanium alloy is cleaned with argon ion.Firstly, deposited TiAlN thin film in titanium alloy surface.Flowmeter is opened, argon gas is made
Flow with nitrogen is respectively 20 sccm and 5 sccm.DC arc source is opened, sputters titanium target in the atmosphere of argon gas and nitrogen
(99.99%), titanium ion forms TiN in conjunction with Nitrogen ion in vacuum, is deposited on titanium alloy surface.In the process, operating pressure
About 5.6 × 10-2Pa, sedimentation time are 150 min, and TiN coating layer thickness is about 1.5 μm.Nitrogen is closed, argon flow is adjusted to
8 sccm.In the case where negative high voltage are -20 kV, two pulsed arc sources are opened, makes it while ionizing fine copper target and pure 120 min of zinc target,
The copper ion of ionization and zinc ion are injected into the titanium alloy of titanium nitride package altogether, obtain the titanium containing copper, zinc ion and close
Golden sample Cu/Zn-TiN-Ti-6Al-4V；The copper ion step-by-step counting is 7195, and zinc ion step-by-step counting is 6940.Its
Middle sedimentation time is 150 minutes, when copper, zinc ion inject altogether, and injection length is 120 minutes altogether.
(2) Fig. 1 be injection after titanium alloy sample (Cu/Zn-TiN-PIII) and preflood titanium alloy hardness line chart,
Hardness after injection is 21.85GPa, high many more obvious than preflood hardness.Illustrate to inject copper, zinc ion in right amount, improve
Thus compactness improves the hardness of film, higher hardness can resist the deformation and damage of material, this is for planting body
It is very important for material.
(3) Fig. 2 protein absorption histogram is shown, the protein of the titanium alloy sample (Cu/Zn-TiN-PIII) after injection
Adsorption capacity improves 17.1% than preflood titanium alloy (TiN-PIII), and the residue of protein on protein electrophorese trace
Also minimum.The result shows that hydrophilic material is better, the adsorption capacity of BSA is higher, is conducive to cell adherence and proliferation.
(4) Fig. 3 is the OD value of the superficial cell of the titanium alloy sample and preflood titanium alloy after injection with incubation time
Variation.Two groups of no difference of science of statistics after cell Proliferation 1 day.This is because living environment is changed, growth cell is in
Unstable state.Therefore cell needs the time to adapt to new environment.After 3d, the increasing of (Cu/Zn-TiN-PIII) cell after injection
Grow slightly above preflood (TiN-PIII).After 5d, this trend is more obvious, shows that Cu/Zn ion is implanted with altogether and is conducive to carefully
The proliferation and vigor of born of the same parents, and no cytotoxicity.
(5) titanium alloy sample (Cu/Zn-TiN-PIII) after Fig. 4 is preflood titanium alloy (TiN-PIII) and injects
The growthform of superficial cell.Compared with TiN-PIII, it is grown in the cell on the surface Cu/Zn-TiN-PIII, there is a large amount of pseudopodium
With more phase spindles, and cell quantity is also more than TiN-PIII.The proliferation of this and cell is consistent, and illustrates copper appropriate, zinc
Content is conducive to cell adherence and proliferation.
It (6) is to cultivate E. coli clones and two groups of samples again on the agar plate of two sample groups in PBS in Fig. 5
Bacteriostasis rate after middle incubation Escherichia coli 24 hours.The results show that the sample of (Cu/Zn-TiN-PIII) is to large intestine bar after injection
The inhibiting effect of bacterium is strong, and bacteriostasis rate improves about 98.47%, and the titanium alloy (Cu/Zn-TiN-PIII) after injection can be mentioned significantly
High in-vitro antibacterial ability.
Conclusion: the more common medical titanium alloy of titanium alloy material that Cu/Zn ion injects TiN package altogether has higher hard
Degree, better wearability, cell compatibility and antibiotic property are expected to extend the service life of medical titanium alloy, orthopaedics afterwards
There is very big application prospect in planting body.
Claims (3)
1. the preparation method that a kind of Cu/Zn injects TiN package titanium alloy altogether, it is characterised in that carried out by following step:
(1) by 10 mm of diameter, the titanium alloy of thickness 2mm uses distilled water, dehydrated alcohol and acetone soln ultrasonic cleaning respectively, instead
Multiple cleaning is several times；
(2) titanium alloy after cleaning in step (1) is put into vacuum chamber, when matrix pressure reaches 10-5-10-7When high vacuum,
Under 400-500V bias, titanium alloy 10-20min is cleaned with argon ion；
(3) after the completion of step (2), flowmeter is opened, makes the flow of argon gas and nitrogen 3:1-9:1 ratio by volume, is opened straight
Arc source is flowed, titanium target (99.99%) 5-180min is sputtered in the atmosphere of argon gas and nitrogen, titanium ion is in conjunction with Nitrogen ion in vacuum
TiN is formed, titanium alloy surface is deposited on, TiN coating is 500nm-2 μm；
(4) after the completion of step (3), nitrogen is closed, argon gas is turned down 3-15sccm flow, in the feelings for opening negative -10--30kV high pressure
Under condition, opens two pulsed arc sources while ionizing fine copper target and pure zinc target 10-120min, the copper ion of ionization and zinc ion are total to
It is injected into the titanium alloy of titanium nitride package, obtains the titanium alloy sample Cu/Zn-TiN-Ti-6Al- containing copper, zinc ion
4V；The copper ion step-by-step counting range is 600-7200, and zinc ion step-by-step counting range is 600-7200.
2. preparation method described in claim 1, wherein sedimentation time is 5-180 minutes, when copper, zinc ion inject altogether, infuse altogether
The angle of incidence is 20-120 minutes.
3. the Cu/Zn-TiN-Ti-6Al-4V using the preparation of claim 1 the method is extending the use of orthopaedics titanium alloy implant
Application in terms of service life.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110180020A (en) * | 2019-05-29 | 2019-08-30 | 中国科学院上海硅酸盐研究所 | A kind of N doping titanium oxide coating and its preparation method and application |
| CN111012581A (en) * | 2019-12-17 | 2020-04-17 | 苏州涂冠镀膜科技有限公司 | Medical ear hook and preparation method thereof |
| CN114927632A (en) * | 2022-05-16 | 2022-08-19 | 湘潭大学 | Modified zinc metal sheet and preparation method and application thereof |
| CN115305438A (en) * | 2021-05-07 | 2022-11-08 | 天津师范大学 | Ag/Ta ion beam surface co-doped titanium nitride/medical titanium alloy and preparation method and application thereof |
| CN115652272A (en) * | 2022-09-27 | 2023-01-31 | 暨南大学 | N and Cu ion implantation titanium alloy modified coating and preparation method and application thereof |
| CN115874350A (en) * | 2021-09-28 | 2023-03-31 | 江苏青昀新材料有限公司 | Mildew-proof polyethylene fabric and production method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004000504A (en) * | 2002-04-09 | 2004-01-08 | Techno Network Shikoku Co Ltd | Intraoral appliance and ion implantation method to intraoral appliance |
| CN101705468A (en) * | 2009-10-14 | 2010-05-12 | 哈尔滨工业大学 | Method for preparing slow-release type skeleton-type TiN/Cu-Zu metal layer antibacterial film |
| CN104046951A (en) * | 2014-06-13 | 2014-09-17 | 西安交通大学 | Method for preparing praseodymium-doped titanium nitride coating on surface of medical titanium alloy |
| CN107304472A (en) * | 2016-04-18 | 2017-10-31 | 中国科学院上海硅酸盐研究所 | Have medical titanium-based composite coat of Bone Defect Repari function and anti-microbial property and preparation method thereof concurrently |
-
2019
- 2019-03-26 CN CN201910230485.6A patent/CN109778132A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004000504A (en) * | 2002-04-09 | 2004-01-08 | Techno Network Shikoku Co Ltd | Intraoral appliance and ion implantation method to intraoral appliance |
| CN101705468A (en) * | 2009-10-14 | 2010-05-12 | 哈尔滨工业大学 | Method for preparing slow-release type skeleton-type TiN/Cu-Zu metal layer antibacterial film |
| CN104046951A (en) * | 2014-06-13 | 2014-09-17 | 西安交通大学 | Method for preparing praseodymium-doped titanium nitride coating on surface of medical titanium alloy |
| CN107304472A (en) * | 2016-04-18 | 2017-10-31 | 中国科学院上海硅酸盐研究所 | Have medical titanium-based composite coat of Bone Defect Repari function and anti-microbial property and preparation method thereof concurrently |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110180020A (en) * | 2019-05-29 | 2019-08-30 | 中国科学院上海硅酸盐研究所 | A kind of N doping titanium oxide coating and its preparation method and application |
| CN110180020B (en) * | 2019-05-29 | 2021-01-12 | 中国科学院上海硅酸盐研究所 | Nitrogen-doped titanium oxide coating and preparation method and application thereof |
| CN111012581A (en) * | 2019-12-17 | 2020-04-17 | 苏州涂冠镀膜科技有限公司 | Medical ear hook and preparation method thereof |
| CN115305438A (en) * | 2021-05-07 | 2022-11-08 | 天津师范大学 | Ag/Ta ion beam surface co-doped titanium nitride/medical titanium alloy and preparation method and application thereof |
| CN115874350A (en) * | 2021-09-28 | 2023-03-31 | 江苏青昀新材料有限公司 | Mildew-proof polyethylene fabric and production method and application thereof |
| CN114927632A (en) * | 2022-05-16 | 2022-08-19 | 湘潭大学 | Modified zinc metal sheet and preparation method and application thereof |
| CN114927632B (en) * | 2022-05-16 | 2024-01-26 | 湘潭大学 | Modified zinc metal sheet and preparation method and application thereof |
| CN115652272A (en) * | 2022-09-27 | 2023-01-31 | 暨南大学 | N and Cu ion implantation titanium alloy modified coating and preparation method and application thereof |
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Application publication date: 20190521 |