CN109771303A - A kind of chlorhexidine gel and preparation method thereof for root canal disinfection - Google Patents
A kind of chlorhexidine gel and preparation method thereof for root canal disinfection Download PDFInfo
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- CN109771303A CN109771303A CN201910198391.5A CN201910198391A CN109771303A CN 109771303 A CN109771303 A CN 109771303A CN 201910198391 A CN201910198391 A CN 201910198391A CN 109771303 A CN109771303 A CN 109771303A
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Abstract
The chlorhexidine gel and preparation method thereof that the invention discloses a kind of for root canal disinfection, the present invention relates to root canal treatments fields.Its raw material of the invention includes: 0.5-1 parts of chlorhexidine by weight, 1-2 parts of lidocaine gel, 0.2-0.5 parts of chlorphenamine maleate, 10-12 parts of glycerol, 10-14 parts of Aloe gel juice, 6-8 parts of albolene, 60-68 parts of pure water, 0.5-0.8 parts of penicillin, 0.6-1 parts and thickener 4-6 parts of tetracycline, specifically includes the following steps: S1, albolene is added to heating and melting in cooking-vessel, temperature control is at 70 DEG C when heating, then by haybox cooking at 60 DEG C, this is used for the chlorhexidine gel and preparation method thereof of root canal disinfection, there can be good Disinfection Effect in root canal disinfection use, avoid infection of the patient by bacterium in endodontic procedure, and there are good anti-inflammatory effects, it can be in root canal treatment rear defence Only surgical site infection ensure that the safety of root canal treatment to a certain extent.
Description
Technical field
It is specially a kind of for the chlorhexidine gel of root canal disinfection and its preparation the present invention relates to root canal treatments field
Method.
Background technique
Root canal treatment is the most commonly used effective treatment method in the world of dental pulp disease and periapical disease.The original of root canal therapy
Reason is the most of infectious agent removed in root canal by mechanically and chemically method, and by root canal filling, closing bizet, prevents from sending out
Raw periapical lesion promotes the healing for the periapical lesion having occurred and that generally require during root canal treatment to tooth
The root canal of tooth carries out disinfection, and is generally carried out disinfection using chlorhexidine gel in existing root canal treatment, Chlorhexidine can be used as washing lotion
Or the ingredient of creme, with the disinfection and cleaning of skin or wound.Or it is used to prepare buccal cavity gel, spray or gargle, treat mouth
Chamber infection, and the preservative for being used as the disinfectant of instrument, putting drops in one's eyes, but existing chlorhexidine gel anti-inflammatory effects are not very
It is good, inflammation is easily caused in endodontic procedure, affects the effect that user uses.
Traditional chlorhexidine gel and preparation method thereof can not have disinfection effect well in root canal disinfection use
Fruit, user is easy the infection by bacterium in endodontic procedure, and does not have good anti-inflammatory effects, can not be in root canal
Operative site inflammation is prevented after treatment, it is difficult to guarantee that the safety of root canal treatment, the postoperative inflammation of patient are easy to damage caused by body
Evil, it is difficult to ensure user using safe, it is not very practical.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of for the chlorhexidine gel of root canal disinfection and its preparation side
Method solves the problems, such as existing chlorhexidine gel narrow antimicrobial spectrum.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs: a kind of chlorine for root canal disinfection is
Determine gel, raw material includes: 0.5-1 parts of chlorhexidine, 1-2 parts of lidocaine gel, chlorphenamine maleate by weight
0.2-0.5 parts, 10-12 parts of glycerol, 10-14 parts of Aloe gel juice, 6-8 parts of albolene, 60-68 parts of pure water, penicillin
0.5-0.8 parts, 0.6-1 parts of tetracycline and 4-6 parts of thickener.
To meet the high-quality aloe barbadensis Miller of organic food requirement as raw material, cleaned, peeling stabilizes Aloe gel juice
Extraction, film filtering and film are concentrated, and have moisturizing, sun-proof, deodorization, preventing obesity, softening skin, anti-inflammatory anti-itch, analgesic, anti-powder
It thorn, freckle and lightens the stain and other effects.
Preferably, raw material includes following component: 0.5 part of chlorhexidine, 2 parts of lidocaine gel, chlorphenamine maleate
0.2 part, 10 parts of glycerol, 14 parts of Aloe gel juice, 6 parts of albolene, 62.2 parts of pure water, 0.5 part of penicillin, tetracycline 0.6
Part and 4 parts of thickener.
Preferably, raw material includes following component: 1 part of chlorhexidine, 1 part of lidocaine gel, chlorphenamine maleate 0.2
Part, 12 parts of glycerol, 10 parts of Aloe gel juice, 8 parts of albolene, 60 parts of pure water, 0.8 part of penicillin, 1 part of tetracycline and thickening
6 parts of agent.
Preferably, raw material includes following component: 0.7 part of chlorhexidine, 2 parts of lidocaine gel, chlorphenamine maleate
0.5 part, 10 parts of glycerol, 10 parts of Aloe gel juice, 6 parts of albolene, 63.4 parts of pure water, 0.6 part of penicillin, tetracycline 0.8
Part and 6 parts of thickener.
Tetracycline is broad-spectrum antibacterial agent, and when high concentration has bactericidal effect, to gram-positive bacteria, negative bacterium, Richettsia,
Filterable virus, Spirochaeta or even protozoon class have good inhibiting effect, and penicillin is one kind of antibiotic, refer to molecule
In containing penam, can destroy the cell wall of bacterium and from the breeding period of bacterial cell bactericidal effect a kind of antibiotic, be
By the antibiotic extracted in Penicillium notatum, skin test must be done before every time, with hypo-allergenic, tetracycline and penicillin are all had very
Good inflammation-diminishing function.
Preferably, the dosage form of the chlorphenamine maleate is tablet.
Preferably, the thickener is Arabic gum, any one in Sodium Hyaluronate and hydroxypropyl methyl cellulose or
Two kinds of combinations, Arabic gum, Sodium Hyaluronate and hydroxypropyl methyl cellulose are safe and harmless thickener, when in use may be used
So that it is whole more thick, convenient for chlorhexidine gel is made.
The invention also discloses a kind of preparation methods of chlorhexidine gel for root canal disinfection, specifically include following step
It is rapid:
S1, albolene is added to heating and melting in cooking-vessel, then temperature control passes through heat preservation at 70 DEG C when heating
Case is kept the temperature at 60 DEG C；
S2, lidocaine gel, glycerol, Aloe gel juice, penicillin and tetracycline are added in cooking-vessel are added
Heat, temperature is 80 DEG C when heating, then by being kept the temperature in incubator, to it inside the pure water of a part is added after carry out
Insulated and stirred obtains intermediate blend；
S3, chlorphenamine maleate is ground by grinding rod, is ground to powdered, then will kept the temperature in S1
Albolene and S2 in the compounding substances that keep the temperature be poured into vessel and be stirred, mixing time is 40 minutes, will be ground
Chlorphenamine maleate be added in vessel and be stirred again, mixing time is 10 minutes, when being without foam in vessel
Can, it is put into vessel and is cooled to room temperature；
S4, chlorhexidine and thickener are added to vessel after cooling in S3, the pure water that another part is then added adds
Carry out uniform stirring after heat, mixing time is 20 minutes, when in vessel without electrodeposition substance, it is then cooling under air-proof condition
It can be prepared by chlorhexidine gel to room temperature.
Preferably, the temperature of incubator inside holding is 60 DEG C in the S1.
Preferably, heating temperature is 60-100 DEG C in the S4.
(3) beneficial effect
The chlorhexidine gel and preparation method thereof that the present invention provides a kind of for root canal disinfection.Have compared with prior art
Standby following the utility model has the advantages that this is used for chlorhexidine gel of root canal disinfection and preparation method thereof, raw material includes: chlorine by weight
0.5-1 parts, 1-2 parts of lidocaine gel, 0.2-0.5 parts of chlorphenamine maleate, 10-12 parts of glycerol, Aloe gel juice are determined
10-14 parts, 6-8 parts of albolene, 60-68 parts of pure water, 0.5-0.8 parts of penicillin, 0.6-1 parts of tetracycline and thickener 4-6
Part, the dosage form of chlorphenamine maleate is tablet, and thickener is Arabic gum, in Sodium Hyaluronate and hydroxypropyl methyl cellulose
The combination of any one or two kinds, can have good Disinfection Effect in root canal disinfection use, avoid endodontic procedure
Infection of the middle user by bacterium, and there are good anti-inflammatory effects, operative site inflammation can be prevented after root canal treatment,
The safety that ensure that root canal treatment to a certain extent avoids the postoperative inflammation of patient damage caused by body, and having ensured makes
User using safe, it is practical.
Specific embodiment
It is clearly and completely described below in conjunction with the technical solution in the embodiment of the present invention, it is clear that described reality
Applying example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general
Logical technical staff every other embodiment obtained without making creative work belongs to what the present invention protected
Range.
The embodiment of the present invention provides a kind of three kinds of technical solutions: preparation method of the chlorhexidine gel for root canal disinfection,
Specifically include following embodiment:
Embodiment 1
S1,6 parts of albolene are added to heating and melting in cooking-vessel, then temperature control passes through at 70 DEG C when heating
Haybox cooking is at 60 DEG C；
S2, by 2 parts of lidocaine gels, 10 parts of glycerol, 14 parts of Aloe gel juices, 0.5 part of penicillin and 0.6 part of tetracycline
Be added in cooking-vessel and heated, temperature is 80 DEG C when heating, then by being kept the temperature in incubator, to it inside be added
Insulated and stirred is carried out after 30 parts of pure water, obtains intermediate blend；
S3,0.2 part of chlorphenamine maleate is ground by grinding rod, be ground to it is powdered, then by S1
The compounding substances kept the temperature in the 6 parts of albolene and S2 of middle heat preservation, which are poured into vessel, to be stirred, and mixing time is 40 minutes,
0.2 part of ground chlorphenamine maleate is added in vessel and is stirred again, mixing time is 10 minutes, works as vessel
It is interior there is no foam, it is put into vessel and is cooled to room temperature；
S4,0.5 part of chlorhexidine and 4 parts of thickeners are added to vessel after cooling in S3, then 32.2 parts of addition is pure
Carry out uniform stirring after water purification heating, mixing time is 20 minutes, when in vessel without electrodeposition substance, then air-proof condition
Under be cooled to room temperature and can be prepared by chlorhexidine gel.
Embodiment 2
S1,8 parts of albolene are added to heating and melting in cooking-vessel, then temperature control passes through at 70 DEG C when heating
Haybox cooking is at 60 DEG C；
S2,1 part of lidocaine gel, 12 parts of glycerol, 10 parts of Aloe gel juices, 0.8 part of penicillin and 1 part of tetracycline are added
Enter and heated into cooking-vessel, temperature is 80 DEG C when heating, then by being kept the temperature in incubator, to it inside be added 30
Insulated and stirred is carried out after the pure water of part, obtains intermediate blend；
S3,0.2 part of chlorphenamine maleate is ground by grinding rod, be ground to it is powdered, then by S1
The compounding substances kept the temperature in the 8 parts of albolene and S2 of middle heat preservation, which are poured into vessel, to be stirred, and mixing time is 40 minutes,
0.2 part of ground chlorphenamine maleate is added in vessel and is stirred again, mixing time is 10 minutes, works as vessel
It is interior there is no foam, it is put into vessel and is cooled to room temperature；
S4,1 part of chlorhexidine and 6 parts of thickeners are added to vessel after cooling in S3,30 parts of pure water is then added
Carry out uniform stirring after heating, mixing time is 20 minutes, when in vessel without electrodeposition substance, it is then cold under air-proof condition
But it can be prepared by chlorhexidine gel to room temperature.
Embodiment 3
S1,6 parts of albolene are added to heating and melting in cooking-vessel, then temperature control passes through at 70 DEG C when heating
Haybox cooking is at 60 DEG C；
S2, by 2 parts of lidocaine gels, 10 parts of glycerol, 10 parts of Aloe gel juices, 0.6 part of penicillin and 0.8 part of tetracycline
Be added in cooking-vessel and heated, temperature is 80 DEG C when heating, then by being kept the temperature in incubator, to it inside be added
Insulated and stirred is carried out after 30 parts of pure water, obtains intermediate blend；
S3,0.5 part of chlorphenamine maleate is ground by grinding rod, be ground to it is powdered, then by S1
The compounding substances kept the temperature in the 6 parts of albolene and S2 of middle heat preservation, which are poured into vessel, to be stirred, and mixing time is 40 minutes,
0.5 part of ground chlorphenamine maleate is added in vessel and is stirred again, mixing time is 10 minutes, works as vessel
It is interior there is no foam, it is put into vessel and is cooled to room temperature；
S4,0.7 part of chlorhexidine and 6 parts of thickeners are added to vessel after cooling in S3, then 33.4 parts of addition is pure
Carry out uniform stirring after water purification heating, mixing time is 20 minutes, when in vessel without electrodeposition substance, then air-proof condition
Under be cooled to room temperature and can be prepared by chlorhexidine gel.
Effect example
Certain chlorhexidine gel processing factory prepares chlorhexidine gel using 1-3 of the embodiment of the present invention, uses embodiment 2
When preparation, discovery bactericidal effect is good after carrying out clinical use to patient, and anti-inflammatory effects are fine, and when patient's use is felt
Feel as snug as a bug in a rug, without obvious allergic reaction and bad phenomenon, when preparation using embodiment 1 and embodiment 3, right
Discovery bactericidal effect is preferable after patient carries out clinical use, and anti-inflammatory effects are general, and when patient's use feels more comfortable, not bright
Aobvious allergic reaction and bad phenomenon, because the chlorhexidine gel using effect drawn a conclusion to prepare in embodiment 2 is best.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of chlorhexidine gel for root canal disinfection, it is characterised in that: its raw material includes: chlorhexidine 0.5- by weight
1 part, 1-2 parts of lidocaine gel, 0.2-0.5 parts of chlorphenamine maleate, 10-12 parts of glycerol, 10-14 parts of Aloe gel juice,
6-8 parts of albolene, 60-68 parts of pure water, 0.5-0.8 parts of penicillin, 0.6-1 parts of tetracycline and 4-6 parts of thickener.
2. a kind of chlorhexidine gel for root canal disinfection according to claim 1, it is characterised in that: its raw material includes such as
Lower component: 0.5 part of chlorhexidine, 2 parts of lidocaine gel, 0.2 part of chlorphenamine maleate, 10 parts of glycerol, Aloe gel juice 14
Part, 6 parts of albolene, 62.2 parts of pure water, 0.5 part of penicillin, 0.6 part of tetracycline and 4 parts of thickener.
3. a kind of chlorhexidine gel for root canal disinfection according to claim 1, it is characterised in that: its raw material includes such as
Lower component: 1 part of chlorhexidine, 1 part of lidocaine gel, 0.2 part of chlorphenamine maleate, 12 parts of glycerol, 10 parts of Aloe gel juice,
8 parts of albolene, 60 parts of pure water, 0.8 part of penicillin, 1 part of tetracycline and 6 parts of thickener.
4. a kind of chlorhexidine gel for root canal disinfection according to claim 1, it is characterised in that: its raw material includes such as
Lower component: 0.7 part of chlorhexidine, 2 parts of lidocaine gel, 0.5 part of chlorphenamine maleate, 10 parts of glycerol, Aloe gel juice 10
Part, 6 parts of albolene, 63.4 parts of pure water, 0.6 part of penicillin, 0.8 part of tetracycline and 6 parts of thickener.
5. a kind of chlorhexidine gel for root canal disinfection according to any one of claims 1-4, it is characterised in that: institute
The dosage form for stating chlorphenamine maleate is tablet.
6. a kind of chlorhexidine gel for root canal disinfection according to any one of claims 1-4, it is characterised in that: institute
Stating thickener is Arabic gum, any one in Sodium Hyaluronate and hydroxypropyl methyl cellulose or two kinds of combinations.
7. a kind of chlorhexidine gel for root canal disinfection described in -6 any one according to claim 1, it is characterised in that: its
Preparation method specifically includes the following steps:
S1, albolene is added to heating and melting in cooking-vessel, then temperature control passes through incubator guarantor at 70 DEG C when heating
Temperature is at 60 DEG C；
S2, lidocaine gel, glycerol, Aloe gel juice, penicillin and tetracycline are added in cooking-vessel and heated, added
Temperature is 80 DEG C when hot, then by being kept the temperature in incubator, to it inside the pure water of a part is added after kept the temperature
Stirring, obtains intermediate blend；
S3, chlorphenamine maleate is ground by grinding rod, be ground to it is powdered, it is then white by what is kept the temperature in S1
The compounding substances kept the temperature in vaseline and S2, which are poured into vessel, to be stirred, and mixing time is 40 minutes, by ground horse
Carry out sour chlorphenamine to be added in vessel and is stirred again, mixing time is 10 minutes, when, without foam, putting in vessel
Enter in vessel and is cooled to room temperature；
S4, chlorhexidine and thickener are added to vessel after cooling in S3, after the pure water heating of another part is then added
Uniform stirring is carried out, mixing time is 20 minutes, when, without electrodeposition substance, being then cooled to room under air-proof condition in vessel
Temperature can be prepared by chlorhexidine gel.
8. a kind of preparation method of chlorhexidine gel for root canal disinfection according to claim 7, it is characterised in that: institute
The temperature for stating incubator inside holding in S1 is 60 DEG C.
9. a kind of preparation method of chlorhexidine gel for root canal disinfection according to claim 7, it is characterised in that: institute
Stating heating temperature in S4 is 60-100 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910198391.5A CN109771303A (en) | 2019-03-15 | 2019-03-15 | A kind of chlorhexidine gel and preparation method thereof for root canal disinfection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910198391.5A CN109771303A (en) | 2019-03-15 | 2019-03-15 | A kind of chlorhexidine gel and preparation method thereof for root canal disinfection |
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| CN109771303A true CN109771303A (en) | 2019-05-21 |
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| CN201910198391.5A Pending CN109771303A (en) | 2019-03-15 | 2019-03-15 | A kind of chlorhexidine gel and preparation method thereof for root canal disinfection |
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Citations (4)
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|---|---|---|---|---|
| US20080268001A1 (en) * | 2007-04-30 | 2008-10-30 | Lynette Zaidel | Oral care composition to reduce or eliminate dental sensitivity |
| EP2520279A1 (en) * | 2011-05-02 | 2012-11-07 | TERES S.r.l. | Thermoreversible gel pharamaceutical compositions for odontoiatric use |
| CN108430430A (en) * | 2015-07-01 | 2018-08-21 | 登士柏希罗纳有限公司 | The canalis radicis dentis filled compositions that can be sterilized, the tip/cone being made from it, and the method that is sterilized |
| CN108743401A (en) * | 2018-05-03 | 2018-11-06 | 北京大学口腔医学院 | A kind of oral cavity root canal sealant and preparation method thereof, application method |
-
2019
- 2019-03-15 CN CN201910198391.5A patent/CN109771303A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080268001A1 (en) * | 2007-04-30 | 2008-10-30 | Lynette Zaidel | Oral care composition to reduce or eliminate dental sensitivity |
| EP2520279A1 (en) * | 2011-05-02 | 2012-11-07 | TERES S.r.l. | Thermoreversible gel pharamaceutical compositions for odontoiatric use |
| CN108430430A (en) * | 2015-07-01 | 2018-08-21 | 登士柏希罗纳有限公司 | The canalis radicis dentis filled compositions that can be sterilized, the tip/cone being made from it, and the method that is sterilized |
| CN108743401A (en) * | 2018-05-03 | 2018-11-06 | 北京大学口腔医学院 | A kind of oral cavity root canal sealant and preparation method thereof, application method |
Non-Patent Citations (1)
| Title |
|---|
| 王朋: "《2%洗必泰根管抑菌凝胶》", 4 May 2018 * |
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Application publication date: 20190521 |