CN109769829A - Bactericidal composition based on 8-hydroxyquinoline - Google Patents

Abstract

The invention discloses one kind to be based on 8-hydroxyquinoline bactericidal composition, trifloxystrobin containing active constituent and 8-hydroxyquinoline, and the mass fraction ratio of trifloxystrobin and 8-hydroxyquinoline is 20:1~1:20；Wherein 8 oxyquinolines can have such as aluminium salt, zinc salt, mantoquita in a salt form.Trifloxystrobin and the mass percentage of 8-hydroxyquinoline in the composition are 0.1%~90%, remaining is auxiliary agent.Composition to plant pathogenic fungi have synergistic effect, especially Leaf Spot Caused by Corynespora cassiicola on Cucumber pathogen melon stick spore bacterium (Corynespora cassiicola(Berk.&Curt.) Wei.).

Description

Bactericidal composition based on 8-hydroxyquinoline

Technical field

The invention belongs to pesticide synergistic compositions fields, and in particular to one kind contains active constituent trifloxystrobin and 8- hydroxyl quinoline The bactericidal composition of quinoline, 8-hydroxyquinoline can exist in a salt form in the composition, specifically can for aluminium salt, zinc salt, Mantoquita.

Background technique

Trifloxystrobin is wide-spectrum bactericide, be from natural products Strobilurins as fungicide lead compound successfully A new class of fungicides of exploitation.With efficient, wide spectrum, protection, treats, roots out, permeates, the punching of systemic activity, resistance to rainwater The characteristics such as brush, lasting period length.To nearly all Mycophytes (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti), disease is such as Powdery mildew, rust, Ying's blight, net blotch, downy mildew, rice blast etc. have good activity.Trifloxystrobin is mainly used at cauline leaf Reason, protection activity is excellent, and has certain therapeutic activity, and activity is not affected by environment.

8-hydroxyquinoline is that white or pale yellow crystals or crystalline powder, not soluble in water and ether are dissolved in ethyl alcohol, third Ketone, chloroform, benzene or diluted acid can distil, and corrosivity is smaller.

Application chemical agent is one of prevention and treatment most effective chemical means of phytopathogen；Prevented with the novel pesticide of not cross resistance Controlling plant disease is a good solution；But according to the research of Phillips McDougall company, compared to 2005-2008 years, between 2010-2014 years, discovery, the average research and development cost increasing of 1 pesticide active ingredient of exploitation and registration 30,000,000 dollars are added, have increased 11.7% in other words, up to 2.86 hundred million dollars.And between 2005-2008 years, agricultural chemicals research and development is put down Equal cost is 2.56 hundred million dollars, increases 39% compared with 2000；Average research and development cost in 2000 is 1.84 hundred million dollars, compared with 1995 Increase 21% year, while the development cycle is 5-10, the speed that the upper pathogen for being difficult to catch up with develops drug resistance；Other methods Such as crop structure adjustment, different pesticide rotations are difficult to play apparent effect in the actual operation process.

Exploitation new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.

Trifloxystrobin is combined with 8-hydroxyquinoline and is had not been reported.

Summary of the invention

The invention discloses a kind of bactericidal compositions, for preventing and treating crop disease, especially Leaf Spot Caused by Corynespora cassiicola on Cucumber.

The invention is realized by the following technical scheme:

Bactericidal composition of the present invention contains active constituent trifloxystrobin and 8-hydroxyquinoline, the mass parts of trifloxystrobin and 8-hydroxyquinoline Number ratio is 20:1~1:20, is preferably in a proportion of 10:1~1:10, is further preferably in a proportion of 5:1~1:5.

The 8-hydroxyquinoline can exist in a salt form in the composition；The salt of the 8-hydroxyquinoline be aluminium salt, Zinc salt, mantoquita etc..The mantoquita is specially copper 8-quinolinolate.The zinc salt is specially bis- (8-hydroxyquinoline) zinc.

The dosage form of the composition is aqueous suspension agent, dispersible oil-suspending agent, water dispersible granules, one in wettable powder Kind.It can be used for preventing and treating disease caused by the phytopathy original, especially Leaf Spot Caused by Corynespora cassiicola on Cucumber.

Trifloxystrobin and the mass percentage of 8-hydroxyquinoline in the composition are 0.1%~90%, remaining is auxiliary agent.

The microbicide compositions are added auxiliary agent and excipients and by certain technological means aqueous suspension agent are made, can be dispersed The agriculturally common dosage form such as oil-suspending agent, water dispersible granules, wettable powder.

The dosage form of water dispersible granule weight percent composition are as follows: trifloxystrobin 0.01~30%, 8-hydroxyquinoline 0.01 ~30%, dispersing agent 0.1~10%, disintegrating agent 0.1~10%, wetting agent 0.1~5%, solid carrier complements to 100%.Specific production Step are as follows: effective component and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, fluidisation is then added It is granulated in bed granulating and drying machine, dries, sieves, the water dispersible granules of corresponding weight percentage are made.

The wettable powder formulation weight percent composition are as follows: trifloxystrobin 0.01~30%, 8-hydroxyquinoline 0.01 ~60%, dispersing agent 0.1~15%, wetting agent 0.1~10%, solid carrier complements to 100%.Specific production stage are as follows: will be effective Ingredient and other auxiliary agents mix, and are uniformly mixed through air-flow crushing again after mechanical crushing, the wettable of corresponding weight percentage is made Property pulvis.

The aqueous suspension agent dosage form weight percent composition are as follows: trifloxystrobin 0.01~30%, 8-hydroxyquinoline 0.01~ 30%, effective component total content is not more than 40%, dispersing agent 0.2~20%, wetting agent 0.2~10%, thickener 0.1~3%, antifreeze Agent 0.1~5%, deionized water carrier complement to 100%.Specific production stage are as follows: mix effective component and other auxiliary agents, through height After being sanded in speed shearing dispersion, sand mill, high dispersive, stable suspension system are formed in water-medium, corresponding weight is made The suspending agent of percentage composition.

The oil-suspending agent dosage form weight percent composition are as follows: trifloxystrobin 0.01~30%, 8-hydroxyquinoline 0.01~ 30%, effective component total content is not more than 40%, dispersing agent 0.2~15%, wetting agent 0.2~8%, thickener 0.1~3%, antifreezing agent 0.1~5%, oiliness carrier carrier complements to 100%.Specific production stage are as follows: mix effective component and other auxiliary agents, through high speed After being sanded in shearing dispersion, sand mill, it is formation high dispersive, stable suspension system in medium in oil, corresponding weight hundred is made Divide the suspending agent of content.

The defoaming agent can be one or more of silicone compound, epoxidized soybean oil, methanol, silicone oil etc..

The antifreezing agent can be one or more of in glycerol, propylene glycol, diethylene glycol (DEG), urea etc..

The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..

The dispersing agent can be APES formaldehyde condensation product, naphthalenesulfonate formaldehyde condensation compound, to first Oxygroup fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkyl phenol polyoxyethylene ether sulfate, alkyl benzene sulphonate Calcium salt, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyethylene glycol stearate, sorbose One or more of alcohol oleate, nekal, polyoxyethylene poly-oxygen propylene aether block polymer etc..

The disintegrating agent can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium, Crospovidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc. One or more of.

The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon black, clay, One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..

The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin, One or more of rosin, wood powder etc..

The emulsifier can be agriculture breast 33#, agriculture breast 34#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#, agriculture breast 1602#, T60, S80, TX-10, OP-10, NP-10, Nonyl pheno (EO=10) ether phosphoric acid Ester, triphenoethyl benzene phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane.

The solvent can be toluene, dimethylbenzene, trimethylbenzene, solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropyl Alcohol, n-butanol, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N- methyl pyrrolidone, acetonitrile, two Chloromethanes, ethyl acetate, methyl oleate, dibutyl phthalate, sec-Butyl Acetate.

The water is deionized water.

The oil system medium is peanut oil, corn oil, sunflower oil, palm oil, methyl oleate, coconut oil, castor oil, dish One or more of seed oil, soybean oil, turpentine oil.

The present composition can also improve control efficiency with other combined use of pesticides or expand prevention spectrum or have to target There is synergistic effect, they may is that

(1) inhibitor of ergosterol synthesis: (1.1) aldimorph (1704-28-5), (1.2) penta ring azoles (azaconazole) (60207-31-0), (1.3) fluorine chlorine ether bacterium azoles, (1.4) bromuconazole (bromuconazole) (116255- 48-2), (1.5) cyproconazole (cyproconazole) (113096-99-4), (1.6) diclobutrazol (diclobutrazole) (75736-33-3), (1.7) Difenoconazole (difenoconazole) (119446-68-3), (1.8) olefin conversion (diniconazole) (83657-24-3), (1.9) olefin conversion-M (diniconazole-M) (83657-18-5), (1.10) Dodemorph (dodemorph) (1593-77-7), (1.11) dodemorfe (dodemorph acetate) (31717-87-0), (1 .12) epoxiconazole (epoxiconazole) (106325-08-0), (1 .13) etaconazole (etaconazole) (60207- 93-4), (1.14) fenarimol (fenarimol) (60168-88-9), (1.15) benzoxazole (fenbuconazole) (114369-43-6), (1.16) fenhexamid (fenhexamid) (126833-17-8), (1.17) fenpropidin (fenpropidin) (67306-00-7), (1.18) butadiene morpholine (fenpropimorph) (67306-03-0), (1.19) quinoline Cycloheximide triazole (fluquinconazole) (136426-54-5), (1.20) flurprimidol (flurprimidole) (56425-91-3), (1.21) Flusilazole (flusilazole) (85509-19-9), (1.22) Flutriafol (flutriafol) (76674-21-0), (1.23) furconazole (furconazole) (112839-33-5), (1.24) furconazole_cis (furconazole-cis) (112839- 32-4), (1 .25) hexaconazole (hexaconazole) (79983-71-4), (1 .26) enzyme (imazalil) (60534- 80-7), (1.27) enzyme sulfate (imazalil sulfate) (58594-72-2), (1.28) glyoxalin (imibenconazole) (86598-92-7), (1.29) kind bacterium azoles (ipconazole) (125225-28-7), (1.30) leaf bacterium Azoles (metconazole) (125116-23-6), (1.31) nitrile bacterium azoles (myclobutanil) (88671-89-0), (1.32) naphthalene Miaow is disliked for fragrant (naftifine) (65472-88-0), (1.33) nuarimol (nuarimol) (63284-71-9), (1.34) Azoles (oxpoconazole) (174212-12-5), (1.35) paclobutrazol (paclobutrazol) (76738-62-0), (1.36) Pefurazoate (pefurazoate) (101903-30-4), (1.37) penconazole (penconazole) (66246-88-6), (1.38) Disease spends spirit (piperalin) (3478-94-2), (1.39) Prochloraz (prochloraz) (67747-09-5), (1 .40) third ring Azoles (propiconazole) (60207-90-1), (1 .41) prothioconazoles (prothioconazole) (178928-70-6), (1.42) pyributicarb (pyributicarb) (88678-67-5), (1.43) pyrifenox (pyrifenox) (88283-41-4) (1.44) azoles oxolinic acide (quinconazole) (103970-75-8), (1.45) simeconazoles (simeconazole) (149508- 90-7), (1.46) spiral shell dislikes luxuriant amine (spiroxamine) (118134-30-8), (1.47) Tebuconazole (tebuconazole) (107534-96-3), (1.48) Terbinafine (terbinafine) (91161-71-6), (1.49) fluorine ether azoles (tetraconazole) (112281-77-3), (1.50) triazolone (triadimefon) (43121-43-3), (1.51) triazole Alcohol (triadimenol) (89482-17-7), (1.52) tridemorph (tridemorph) (81412-43-3), (1.53) fluorine bacterium Azoles (triflumizole) (68694-11-1), (1.54) triforine (triforine) (26644-46-2), (1.55) pentylidene azoles Bacterium (triticonazole) (131983-72-7), (1.56) uniconazole P (uniconazole) (83657-22-1), (1 .57) High uniconazole P (uniconazole-p) (83657-17-4), (1 .58) alkene frost benzyl azoles (viniconazole) (77174-66- 4), (1.59) voriconazole (voriconazole) (137234-62-9), (1.60) 1- (4- chlorphenyl) -2- (1H-1,2,4- Triazol-1-yl) suberol (129586-32-9), (1.61) 1- (2,2- dimethyl -2,3- dihydro -1H- indenes -1- base) -1H- miaow Azoles -5- carboxylate methyl ester (110323-95-0), (1.62) N'- { 5- (difluoromethyl) -2- methyl -4- [3- (trimethyl silyl Base) propoxyl group] phenyl }-N- ethyl-N-methyl imino group formamide, (1.63) N- ethyl-N-methyl-N'- { 2- methyl -5- (trifluoromethyl) -4- [3- (trimethyl silyl) propoxyl group] phenyl } imino group formamide and (1.64) O- { 1- [(4- first Phenoxy base) -3,3- dimethyl butyrate -2- base } -1H- imidazoles -1- sulfocarbonate (111226-71-2).

(2) inhibitor of electron transport chain complex I or II: such as (2.1) bixafen (581809-46-03), (2.2) pyridine acyl

Bacterium amine (boscalid) (188425-85-6), (2.3) carboxin (carboxin) (5234-68-4), the phonetic bacterium of (2.4) fluorine Amine

(diflumetorim) (130339-07-0), (2.5) fenfuram (fenfuram) (24691-80-3), (2.6) fluorine pyrrole Bacterium amine (fluopyram) (658066-35-4), (2.7) fluorine indenes azoles bacterium amine, (2.8) fluxapyroxad (907204-31-3), (2.9) furan pyrazoles clever (furametpyr) (123572-88-3), (2.10) seed dressing amine (furmecyclox) (60568-05-0), (2.11) naphthalene pyrrole bacterium amine (isopyrazam, the racemic modification 1RS, 4SR, 9RS of cis--epimerism and trans--epimerism The mixture of racemic modification 1RS, 4SR, 9SR) (88165-58-1), (2.12) naphthalene pyrrole bacterium amine (isopyrazam, it is trans--difference to The racemic modification 1RS, 4SR, 9SR of isomery), (mapping of isopyrazam, trans--epimerism are different for (2 .13) naphthalene pyrrole bacterium amine Structure body 1R, 4S, 9S), (2.14) naphthalene pyrrole bacterium amine (isopyrazam, the enantiomter 1S, 4R, 9R of trans--epimerism), (2.15) naphthalene pyrrole bacterium amine (isopyrazam, the racemic modification 1RS, 4SR, 9RS of cis--epimerism), (2.16) naphthalene pyrrole bacterium amine (isopyrazam, the enantiomter 1R, 4S, 9R of cis--epimerism), (2.17) naphthalene pyrrole bacterium amine (isopyrazam, it is suitable Formula-epimerism enantiomter 1S, 4R, 9S), (2.18) mebenil (mepronil) (55814-41-0), (2.19) oxygen Change carboxin (oxycarboxin) (5259-88-1), (2.20) penflufen-containing (penflufen) (494793-67-8), (2.21) pyrrole metsulfovax (penthiopyrad) (183675-82-3), (2.22) cyclopamine (sedaxane) (874967- 67-6), (2.23) thifluzamide (thifluzamide) (130000-40-7), (2.24) 1- methyl-N- [2- (1,1,2,2- tetra- Fluorine ethyoxyl) phenyl] -3- (trifluoromethyl) -1H- pyrazole-4-carboxamide, (2.25) 3- (difluoromethyl) -1- methyl-N- [2- (1,1,2,2- tetrafluoro ethyoxyl) phenyl] -1H- pyrazole-4-carboxamide, (2.26) 3- (difluoromethyl)-N- [the fluoro- 2- of 4- (1,1, 2,3,3,3- hexafluoro propoxyl group) phenyl] -1- methyl-1 H- pyrazole-4-carboxamide, (2.27) N- [1- (2,4 dichloro benzene base) -1- Methoxy propane -2- base] -3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide (1092400-95-7) (WO2008148570), the fluoro- N- of (2.28) 5,8- bis- [2- (the fluoro- 4- of 2- { [4- (trifluoromethyl) pyridine -2- base] oxygroup } phenyl) Ethyl] quinazoline -4- amine (1210070-84-0) (WO2010025451), (2.29) N- [9- (dichloromethylene) -1,2,3,4- Tetrahydro -1,4- methanonaphthalene -5- base] -3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide, (2.30) N- [(1S, 4R) -9- (dichloromethylene) -1,2,3,4- tetrahydro -1,4- methanonaphthalene -5- base] -3- (difluoromethyl) -1- methyl-1 H- pyrrole Azoles -4- formamide and (2.31) N- [(1R, 4S) -9- (dichloromethylene) -1,2,3,4- tetrahydro -1,4- methanonaphthalene -5- base] - 3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide.

(3) inhibitor of electron transport chain complex III: such as (3.1) ametoctradin (865318-97-4), (3.2) Yin Azoles flusulfamide (amisulbrom) (348635-87-0), (3.3) nitrile Fluoxastrobin (azoxystrobin) (131860-33-8), (3.4) cyazofamid (cyazofamid) (120116-88-3), (3.5) coumethoxystrobin (850881-30-0), (3.6) coumoxystrobin (850881-70-8), (3.7) dimoxystrobin (dimoxystrobin) (141600-52-4), (3.8) Enestroburin (enestroburin) (238410-11-2) (WO2004/058723), (3.9) Famoxate (famoxadone) (131807-57-3) (WO2004/058723), (3.10) imidazoles bacterium (fenamidone) (161326-

34-7) (WO2004/058723), (3 .11) fenoxystrobin (918162-02-4), (3 .12) fluoxastrobin (fluoxastrobin) (361377-29-9) (WO2004/058723), (3.13) kresoxim-methyl (kresoxim-methyl)

(143390-89-0) (WO2004/058723), (3.14) SSF 126 (metominostrobin) (133408-50-1)

(WO2004/058723), (3.15) orysastrobin (orysastrobin) (189892-69-1) (WO2004/058723),

(3.16) ZEN 90160 (picoxystrobin) (117428-22-5) (WO2004/058723), (3.17) pyraclostrobin

(pyraclostrobin)(175013-18-0)(WO2004/058723)、(3.18)pyrametostrobin (915410-70-

7)(WO2004/058723)、(3.19)pyraoxystrobin(862588-11-2)(WO2004/058723)、(3.20)

pyribencarb(799247-52-2)(WO2004/058723)、(3.21)triclopyricarb(902760-40- 1), (3.22) benziothiazolinone, (3.23) (2E) -2- (2- { [6- (3- chloro-2-methyl phenoxy group) -5-FU -4- base] oxygroup } benzene Base) -2- (methoxyimino)-N- methylacetamide (WO2004/058723), (3.24) (2E) -2- (methoxyimino) - N- methyl -2- (2- { [({ (1E) -1- [3- (trifluoromethyl) phenyl] ethylidene } amino) oxygroup] methyl } phenyl) acetamide (WO2004/058723), (3.25) (2E) -2- (methoxyimino)-N- methyl -2- { 2- [(E)-({ 1- [3- (fluoroform Base) phenyl] ethyoxyl } imino group) methyl] phenyl } acetamide (158169-73-4), (3.26) (2E) -2- { 2- [({ [(1E) - 1- (3- { [the fluoro- 2- phenyl vinyl of (E) -1-] oxygen } phenyl) ethylidene] amino } oxygroup) methyl] phenyl } (methoxyl group is sub- by -2- Amino)-N- methylacetamide (326896-28-0), (3.27) (2E) -2- { 2- [({ [(2E, 3E) -4- (2,6- dichlorophenyl) Butyl- 3- alkene -2- subunit] amino } oxygroup) methyl] benzene

Base } -2- (methoxyimino)-N- methylacetamide, the chloro- N- of (3.28) 2- (1,1,3- trimethyl -2,3- dihydro -1H- Indenes -4- base) pyridine-3-carboxamide (119899-14-8), (3.29) 5- methoxyl group -2- methyl -4- (2- { [({ (1E) -1- [3- (trifluoromethyl) phenyl] ethylidene } amino) oxygroup] methyl } phenyl) -2,4- dihydro -3H-1,2,4- triazole -3- ketone, (3.30) (2E) -2- { 2- [({ cyclopropyl [(4- methoxyphenyl) imino group] methyl } sulfenyl) methyl] phenyl } -3- methoxy propyl -2- alkene Sour methyl esters (149601-03-6), (3.31) N- (3- ethyl -3,5,5- trimethylcyclohexyl) -3- (formamido group) -2- hydroxy benzenes Formamide (226551-21-9), (3.32) 2- { 2- [(2,5- dimethyl phenoxy) methyl] phenyl } -2- methoxy-. N-methyl Acetamide (173662-97-0) and (3.33) (2R) -2- { 2- [(2,5- dimethyl phenoxy) methyl] phenyl } -2- methoxyl group - N- methylacetamide (394657-24-0).

(4) mitosis and cell division inhibitor: such as (4.1) benomyl (benomyl) (17804-35-2),

(4.2) carbendazim (carbendazim) (10605-21-7), (4.3) benzene imidazoles bacterium (chlorfenazole) (3574- 96-7)、

(4.4) diethofencarb (diethofencarb) (87130-20-9), (4.5) Han Lening (ethaboxam) (162650-77- 3)、

(4.6) fluopicolide (fluopicolide) (239110-15-7), (4.7) furidazol (fuberidazole) (3878-19-

1), (4.8) Pencycuron (pencycuron) (66063-05-6), (4.9) Apl-Luster (thiabendazole) (148-79- 8)、

(4.10) thiophanate methyl (thiophanate-methyl) (23564-05-8), (4.11) thiophanate (23564- 06-

9), (4.12) zoxamide (zoxamide) (156052-68-5), the chloro- 7- of (4.13) 5- (4- methyl piperidine -1- base) - 6-(2,

4,6- trifluorophenyl) [1,2,4] triazole [1,5-a] pyrimidine (214706-53-3) and the chloro- 5- of 3- (6- chloropyridine -3- Base) -6-

Methyl -4- (2,4,6- trifluorophenyl) pyridazine (1002756-87-7).

(5) compound that can there is multidigit point to act on: such as (5.1) Bordeaux mixture (bordeauxmixture) (8011-

63-0), (5.2) difoltan (captafol) (2425-06-1), (5.3) captan (captan) (133-06-2) (WO02/

12172), (5.4) Bravo (chlorothalonil) (1897-45-6), (5.5) Kocide SD (20427-59-2), (5.6)

Copper naphthenate (1338-02-9), (5.7) copper oxide (1317-39-1), (5.8) copper oxychloride (1332-40-7), (5.9) Copper sulphate (2+) (7758-98-7), (5.10) Euparen (dichlofluanid) (1085-98-9), (5.11) dithianon

(dithianon) (3347-22-6), (5.12) dodine (dodine) (2439-10-3), (5.13) dodine free alkali

(dodine free base), (5.14) fervam (ferbam) (14484-64-1), (5.15) fluorofolpet (719-

96-0), (5.16) folpet (folpet) (133-07-3), (5.17) biguanides pungent salt (guazatine) (108173-90- 6)、

(5.18) guazatine acetate (guazatine acetate), (5.19) iminoctadine (iminoctadine) (13516- 27-

3), (5.20) double eight guanidine salts (iminoctadine albesilate) (169202-06-6), (5.21) iminoctadine second Hydrochlorate

(iminoctadine triacetate) (57520-17-9), (5.22) mancopper (mancopper) (53988-93- 5)、

(5.23) Mancozeb (mancozeb) (8018-01-7), (5.24) maneb (maneb) (12427-38-2), (5.25) Carbatene (metiram) (9006-42-2), (5.26) Carbatene zinc (metiram zinc) (9006-42-2), (5.27) zinc thiazole, (5.28) propamidine (104-32-5), (5.29) Propineb (propineb) (12071-83-9), (5.30) sulphur and sulphur preparation include calcium polysulfide (calcium polysulphide) (7704-34-9), (5.31) thiram (thiram) (137-26-8), (5.32) tolyfluanid (tolylfluanid) (731-27-1), (5.33) zineb (zineb) (12122-67-7) and (5.34) ziram (ziram) (137-30-4).

(6) compound of host defense can be induced: such as (6.1) diazosulfide (acibenzolar-S-methyl)

(135158-54-2), (6.2) isotianil (isotianil) (224049-04-1), (6.3) probenazole (probenazole)

(27605-76-1) and (6.3) tiadinil (tiadinil) (223580-51-6).

(7) amino acid and/or protein biology synthetic inhibitor: for example (7.1) amine puts out (andoprim) (23951-85-

1), (7.2) blasticidin-S (blasticidin-S) (2079-00-7), (7.3) cyprodinil (cyprodinil) (121552-61-

2), (7 .4) kasugarnycin (kasugamycin) (6980-18-3), (7 .5) kasugamycini hydrochloride hydrate

(kasugamycinhydrochloride hydrate) (19408-46-9), (7.6) mepanipyrim (mepanipyrim)

(110235-47-7), (7.7) pyrimethanil (pyrimethanil) (53112-28-0) and 3- (5- fluoro- 3,3,4, 4- tetra-

Methyl -3,4- dihydro-isoquinoline -1- base) quinoline (861647-32-7) (WO2005070917).

(8) ATP generates inhibitor: (8.1) fentin acetate (fentin acetate) (900-95-8), (8.2) three

Benzene tin chlorine (fentin chloride) (639-58-7), (8.3) fentin hydroxide (fentin hydroxide) (76-87-9) (8.4) Silthiopham (silthiofam) (175217-20-6).

(9) Cell wall synthesis inhibitor: such as (9.1) benzene metsulfovax (benthiavalicarb) (177406-68-7),

(9.2) dimethomorph (dimethomorph) (110488-70-5), (9.3) flumorph (flumorph) (211867-47- 9)、

(9.4) iprovalicarb (iprovalicarb) (140923-17-7), (9.5) mandipropamid (mandipropamid) (374726-

62-2), (9.6) polyoxin (polyoxins) (11113-80-7), (9.7) Polyoxin (polyoxorim) (22976-

86-9), (9.8) Validacin (Takeda) (validamycin A) (37248-47-8) and (9.9) valifenalate (283159-94-

4;283159-90-0)。

(10) lipid and film synthetic inhibitor: such as (10.1) biphenyl (biphenyl) (92-52-4), (10.2) chloroneb

(chloroneb) (2675-77-6), (10 .3) botran (dicloran) (99-30-9), (10 .4) edifenphos (edifenphos) (17109-49-8), (10.5) kobam (etridiazole) (2593-15-9), (10.6) iodocarb

(55406-53-6), (10 .7) different rice blast net (iprobenfos) (26087-47-8), (10 .8) rice blast Spirit

(isoprothiolane) (50512-35-1), (10.9) Propamocarb (propamocarb) (25606-41-1), (10.10) white

Mould prestige hydrochloride (propamocarb-hydrochloride) (25606-41-1), (10.11) prothiocarb (prothiocarb)

(19622-08-3), (10 .12) Ppyrazophos (pyrazophos) (13457-18-6), (10 .13) pentachloronitrobenzene

(quintozene) (82-68-8), (10.14) tecnazene (tecnazene) (117-18-0) and (10.15) methyl It stands withered

Phosphorus (tolclofos-methyl) (57018-04-9).

(11) melanin biosynthesis inhibitor: such as (11.1) ring propionyl bacterium amine (carpropamid) (104030-54-

8), (11.2) chlorine zarilamid (diclocymet) (139920-32-4), (11.3) fenoxanil (fenoxanil) (115852-

48-7), (11.4) Rabcide (phthalid) (27355-22-2), (11.5) pyroquilon (pyroquilon) (57369-32-

1), (11.6) tricyclazole (tricyclazole) (41814-78-2) and (11.7) { 3- methyl-1-[(4- toluyl Base)

Amino] butane -2- base } carbamic acid 2,2,2- trifluoro ethyl ester (851524-22-6) (WO2005042474).

(12) nucleic acid synthetic inhibitor: such as (12.1) M 9834 (benalaxyl) (71626-11-4), (12.2) refining benzene

White spirit (benalaxyl-M, kiralaxyl) (98243-83-5), phonetic bacterium spirit (the bupirimate) (41483- of (12.3) sulphur 43-6), (12.4) clozylacon (67932-85-8), (12.5) Milcurb (dimethirimol) (5221-53-4), (12.6) Milstem (ethirimol) (23947-60-6), (12.7) Furalaxyl (furalaxyl) (57646-30-7), (12.8) hydroxyisoxazole (hymexazole) (10004-44-1), (12.9) metalaxyl (metalaxyl) (57837-19-1), (12.10) Metalaxyl-M (metalaxyl-M, mefenoxam) (70630-17-0), (12.11) fenfuram (ofurace) (58810-48-3), (12.12) Wakil (oxadixyl) (77732-09-3) and (12.13) oxolinic acide (oxolinic acid)(14698-29-4)。

(13) signal transduction inhibitor: such as (13.1) chlozolinate (chlozolinate) (84332-86-5), (13.2)

Fenpiclonil (fenpiclonil) (74738-17-3), (13.3) fluorine dislike bacterium (fludioxonil) (131341-86-1), (13.4)

Isopropyl fixed (iprodione) (36734-19-7), (13.5) procymidone (procymidone) (32809-16-8), (13.6) quinoxyfen (quinoxyfen) (124495-18-7) and (13.7) vinclozolin (vinclozolin) (50471-44-8).

It (14) can be as the compound of uncoupler: such as (14.1) binapacryl (binapacryl) (485-31-4),

(14.2) dinocap (dinocap) (131-72-6), (14.3) ferimzone (ferimzone) (89269-64-7), (14.4) fluorine

Pyridine amine (fluazinam) (79622-59-6) and (14.5) meptyldinocap (131-72-6).

(15) other compounds, such as (15.1) benthiozole (benthiazole) (21564-17-0), (15.2) Bethoxazin (163269-30-5), (15.3) capsimycin (capsimycin) (70694-08-5), (15.4) carvol (carvone) (99-49-0), (15.5) chinomethionat (chinomethionat) (2439-01-2), (15.6) pyriofenone (chlazafenone) (688046-61-9), (15.7) cufraneb (cufraneb) (11096-18-7), (15.8) cyflufenamid (cyflufenamid) (180409-60-3), (15.9) cymoxanil (cymoxanil) (57966-95-7), (15.10) cyclopropyl sulphur Amide (cyprosulfamide) (221667-31-8), (15.11) dazomet (dazomet) (533-74-4), (15.12) miaow bacterium Prestige (debacarb) (62732-91-6), (15.13) antiphen (dichlorophen) (97-23-4), (15.14) diclomezin (diclomezine) (62865-36-5), (15.15) difenzoquat (difenzoquat) (49866-87-7), (15.16) wild swallow Withered Methylsulfate (difenzoquat methylsulphate) (43222-48-6), (15 .17) diphenylamines (diphenylamine)(122-39-4)、(15.18)ecomate、(15.19)fenpyrazamino(473798-59-3)、

(15.20) fluorine acyl bacterium amine (flumetover) (154025-04-4), (15.21) fluoromide (fluoroimide)

(41205-21-4), (15.22) flusulfamide (flusulfamide) (106917-52-6), (15.23) flutianil (304900-25-2), (15.24) fosetyl-aluminium (fosetyl-aluminium) (39148-24-8), (15.25) ethane phosphonic acid calcium, (15.26) ethane phosphonic acid sodium (39148-16-8), (15.27) hexachloro-benzene (hexachlorobenzene) (118-74-1), (15.28) human world mycin (irumamycin) (81604-73-1), (15.29) methasulfocarb (methasulfocarb) (66952- 49-6), (15.30) methyl-isorhodanate (556-61-6), (15.31) metrafenone (metrafenone) (220899-03-6), (15.32) midolthromycin (mildiomycin) (67527-71-3), (15.33) myprozine (natamycin) (7681-93- 8), (15.34) Sankel (nickel dimethyl dithiocarbamate) (15521-65-0), (15.35) nitrothalisopropyl (nitrothal-isopropyl) (10552-74-6), (15.36) different thiophene bacterium ketone (octhilinone) (26530-20-1),

(15.37) oxamocarb (917242-12-7), (15.38) oxyfenthiin (34407-87-9), (15.39) pentachloro- Phenol

(pentachlorophenol) and its salt (87-86-5), (15.40) phenothrin (phenothrin), (15.41) phosphorus Acid and

Its salt (13598-36-2), (15.42) propamocarb-fosetylate, (15.43) propanosine-sodium

(88498-02-6), (15.44) the third oxygen quinoline (proquinazid) (189278-12-4), (15.45) pyrimorph

(868390-90-3), (15.45e) (2E) -3- (4- tert-butyl-phenyl) -3- (2- chloropyridine -4- base) -1- (morpholine -4- Base)

Propyl- 2- alkene -1- ketone (1231776-28-5), (15.45z) (2Z) -3- (4- tert-butyl-phenyl) -3- (2- chloropyridine -4- Base) -1-

(morpholine -4- base) propyl- 2- alkene -1- ketone (1231776-29-6), (15.46) pyrroles's rhzomorph (pyrrolnitrine) (1018-71-

9) (EP-A1559320), (15.47) tebufloquin (376645-78-2), (15.48) tecloftalam (tecloftalam)

(76280-91-6), (15.49) tolnifanide (304911-98-6), (15.50) azoles bacterium piperazine (triazoxide) (72459-

58-6), (15.51) trichlamide (trichlamide) (70193-21-4), (15.52) zarilamid (zarilamid)

(84527-51-5), (15.53) (3S, 6S, 7R, 8R) -8- benzyl -3- [({ 3- [(isobutyl acyloxy) methoxyl group] -4- first Oxygroup

Pyridine -2- base } carbonyl) amino] -6- methyl -4,9- dioxy -1,5- dioxolanes -7- base 2 Methylpropionic acid ester (517875-34-2) (WO2003035617), (15.54) 1- (4- 4- [(5R)-5- (2,6- difluorophenyl) dihydro-1-4,5-, 2- oxazole -3- base] -1,3- thiazol-2-yl } piperidin-1-yl) -2- [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] second Ketone (1003319-79-6) (WO2008013622), (15.55) 1- (4- { 4- [(5S) -5- (2,6- difluorophenyl) -4,5- two Hydrogen -1,2- oxazole -3- base] -1,3- thiazol-2-yl } piperidin-1-yl) -2- [5- methyl -3- (trifluoromethyl) -1H- pyrazoles -1- Base] ethyl ketone (1003319-80-9) (WO2008013622), (15.56) 1- (4- { 4- [5- (2,6- difluorophenyl) -4,5- two Hydrogen -1,2- oxazole -3- base] -1,3- thiazol-2-yl } piperidin-1-yl) -2- [5- methyl -3- (trifluoromethyl) -1H- pyrazoles -1- Base] ethyl ketone (1003318-67-9) (WO2008013622), (15.57) 1- (4- methoxyphenoxy) -3,3- dimethylbutane - 2- base 1H- imidazoles -1- carboxylate (111227-17-9), chloro- 4- (methyl sulphonyl) pyridine of (15.58) 2,3,5,6- tetra- (13108-52-6), (15.59) 2,3- dibutyl -6- chlorothiophene simultaneously [2,3-d] pyrimidine -4 (3H) -one (221451-58-7), (15.60) [1,4] two thiophene English of 2,6- dimethyl -1H, 5H- simultaneously -1,3,5,7 (2H, 6H)-four of [2,3-c:5,6-c'] two pyrroles Ketone, (15.61) 2- [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] -1- (4- { 4- [(5R) -5- phenyl -4,5- dihydro - 1,2- oxazole -3- base] -1,3- thiazol-2-yl } piperidin-1-yl) ethyl ketone (1003316-53-7) (WO2008013622), (15.62) 2- [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] -1- (4- 4- [dihydro -1 (5S) -5- phenyl -4,5-, 2- oxazole -3- base] -1,3- thiazol-2-yl } piperidin-1-yl) ethyl ketone (1003316-54-8) (WO2008013622), (15.63) 2- [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] -1- { 4- [4- (5- phenyl -4,5- dihydro -1,2- oxazole -3- base) - 1,3- thiazol-2-yl] piperidin-1-yl } ethyl ketone (1003316-51-5) (WO2008013622), (15.64) 2- butoxy -6- Iodo- 3- propyl -4H- benzopyran-4-one, the chloro- 5- of (15.65) 2- [the chloro- 1- of 2- (the fluoro- 4- methoxyphenyl of 2,6- bis-) -4- first Base -1H- imidazoles -5- base] pyridine, (15.66) 2- phenylphenol and its salt (90-43-7), (15.67) 3- (4,4,5- tri- fluoro- 3, 3- dimethyl -3,4- dihydro-isoquinoline -1- base) quinoline (861647-85-0) (WO2005070917) (15.68) 3,4,5- trichlorine Pyridine -2,6- dintrile (17824-85-0), (15.69) 3- [5- (4- chlorphenyl) -2,3- dimethyl -1,2- oxazolidine -3- base] Pyridine, (15.70) 3- chloro- 5- (4- chlorphenyl) -4- (2,6- difluorophenyl) -6- methyl pyridazine, (15.71) 4- (4- chlorobenzene Base) -5- (2,6- difluorophenyl) -3,6- diformazan radical pyridazine, (15.72) 5- amino -1,3,4- thiadiazoles -2- mercaptan, (15.73) The chloro- N'- phenyl-N'- of 5- (propyl- 2- alkynes -1- base) thiophene -2- sulfohydrazide (134-31-6), (15.74) 5- fluoro- 2- [(4- fluorine benzyl Base) oxygroup] pyrimidine -4- amine (1174376-11-4) (WO2009094442), the fluoro- 2- of (15.75) 5- [(4- methylbenzyl) oxygen Base] pyrimidine -4- amine (1174376-25-0) (WO2009094442), (15.76) 5- methyl -6- octyl [1,2,4] triazol [1, 5-a] pyrimidine -7- amine, (15.77) (2Z) -3- amino -2- cyano -3- phenyl propyl- 2- acetoacetic ester, (15.78) N'- (4- { [3- (4- chlorobenzyl) -1,2,4- thiadiazoles -5- base] oxygroup } -2,5- 3,5-dimethylphenyl)-N- ethyl-N-methyl imino group formamide, (15.79) N- (4- chlorobenzyl) -3- [3- methoxyl group -4- (propyl- 2- alkynes -1- oxygroup) phenyl] propionamide, (15.80) N- [(4- chlorine Phenyl) (cyano) methyl] -3- [3- methoxyl group -4- (propyl- 2- alkynes -1- oxygroup) phenyl] propionamide, (15.81) N- [(bromo- 3- of 5- Chloropyridine -2- base) methyl] -2,4- dichloropyridine -3- formamide, (15.82) N- [1- (the bromo- 3- chloropyridine -2- base of 5-) second Base] -2,4- dichloropyridine -3- formamide, (15.83) N- [1- (the bromo- 3- chloropyridine -2- base of 5-) ethyl] fluoro- 4- iodo pyrrole of -2- Pyridine -3- formamide, (15.84) N- { (E)-[(cyclo propyl methoxy) imino group] [6- (difluoro-methoxy) -2,3- difluorophenyl] Methyl } -2- phenyl-acetamides (221201-92-9), (15.85) N- { (Z)-[(cyclo propyl methoxy) imino group] [6- (difluoro Methoxyl group) -2,3- difluorophenyl] methyl } -2- phenyl-acetamides (221201-92-9), (15.86) N'- { 4- [(3- tert-butyl - 4- cyano -1,2-17 thiazole -5- base) oxygroup] the chloro- 5- aminomethyl phenyl of -2- }-N- ethyl-N-methyl imino group formamide, (15.87) N- methyl -2- (1- { [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] acetyl group } piperidin-4-yl)-N- (1, 2,3,4- naphthane -1- base) -1,3- thiazole -4-carboxamide (922514-49-6) (WO2007014290), (15.88) N- first Base -2- (1- { [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] acetyl group } piperidin-4-yl)-N- [(1R) -1,2,3,4- Naphthane -1- base] -1,3- thiazole -4-carboxamide (922514-07-6) (WO2007014290), (15.89) N- methyl -2- (1- { [5- methyl -3- (trifluoromethyl) -1H- pyrazol-1-yl] acetyl group } piperidin-4-yl)-N- [(1S) -1,2,3,4- naphthane - 1- yl] -1,3- thiazole -4-carboxamide (922514-48-5) (WO2007014290), (15.90) { 6- [({ [(1- methyl-1 H- Tetrazolium -5- base) (phenyl) methylene] amino } oxygroup) methyl] pyridine -2- base } amyl carbamate, (15.91) azophenlyene -1- carboxylic Acid, (15.92) quinoline -8- alcohol (134-31-6), (15.93) quinoline -8- alcohol sulfate (2:1) (134-31-6) and (15.94) { 6- [({ [(1- methyl-1 H- tetrazolium -5- base) (phenyl) methylene] amino } oxygroup) methyl] pyridine -2- base } carbamic acid uncle Butyl ester.

(16) other compounds, such as (16.1) 1- methyl -3- (trifluoromethyl)-N- [2'- (trifluoromethyl) biphenyl -2- Base] -1H- pyrazole-4-carboxamide, (16.2) N- (4'- chlordiphenyl -2- base) -3- (difluoromethyl) -1- methyl-1 H- pyrazoles -4- Formamide, (16.3) N- (2', 4'- dichlorobenzene -2- base) -3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide, (16.4) 3- (difluoromethyl) -1- methyl-N- [4'- (trifluoromethyl) biphenyl -2- base] -1H- pyrazole-4-carboxamide, (16.5) N- (2', 5'- DfBP -2- base) -1- methyl -3- (trifluoromethyl) -1H- pyrazole-4-carboxamide, (16.6) 3- (difluoro first Base) -1H- pyrazole-4-carboxamide is (by WO2004/058723 by -1- methyl-N- [4'- (propyl- 1- alkynes -1- base) biphenyl -2- base] Know), the fluoro- 1,3- dimethyl-N-of (16.7) 5- [4'- (propyl- 1- alkynes -1- base) biphenyl -2- base] -1H- pyrazole-4-carboxamide (by Known to WO2004/058723), the chloro- N- of (16.8) 2- [4'- (propyl- 1- alkynes -1- base) biphenyl -2- base] pyridine-3-carboxamide (by WO2004/058723), (16.9) 3- (difluoromethyl)-N- [4'- (3,3- dimethyl butyrate -1- alkynes -1- base) biphenyl -2- base] -1- Methyl-1 H- pyrazole-4-carboxamide (as known to WO2004/058723), (16.10) N- [4'- (3,3- dimethyl butyrate -1- alkynes -1- Base) biphenyl -2- base] the fluoro- 1,3- dimethyl -1H- pyrazole-4-carboxamide (as known to WO2004/058723) of -5-, (16.11) 3- - 1- methyl-1 H- pyrazole-4-carboxamide is (by WO2004/058723 by (difluoromethyl)-N- (4'- acetenyl biphenyl -2- base) Know), (16.12) N- (4'- acetenyl biphenyl -2- base) fluoro- 1,3- dimethyl -1H- pyrazole-4-carboxamide of -5- is (by WO2004/ Known to 058723), pyridine-3-carboxamide is (by WO2004/058723 by the chloro- N- of (16.13) 2- (4'- acetenyl biphenyl -2- base) Know), the chloro- N- of (16.14) 2- [4'- (3,3- dimethyl butyrate -1- alkynes -1- base) biphenyl -2- base] pyridine-3-carboxamide (by Known to WO2004/058723), (16.15) 4- (difluoromethyl) -2- methyl-N- [4'- (trifluoromethyl) biphenyl -2- base] -1,3- Thiazole -5- formamide (as known to WO2004/058723), the fluoro- N- of (16.16) 5- [4'- (3- hydroxy-3-methyl butyl- 1- alkynes -1- Base) biphenyl -2- base] -1,3- dimethyl -1H- pyrazole-4-carboxamide (as known to WO2004/058723), the chloro- N- of (16.17) 2- [4'- (3- hydroxy-3-methyl butyl- 1- alkynes -1- base) biphenyl -2- base] pyridine-3-carboxamide (as known to WO2004/058723), (16.18) 3- (difluoromethyl)-N- [4'- (3- methoxyl group -3- methyl butyl- 1- alkynes -1- base) biphenyl -2- base] -1- methyl-1 H- Pyrazole-4-carboxamide (as known to WO2004/058723), the fluoro- N- of (16.19) 5- [4'- (3- methoxyl group -3- methyl butyl- 1- alkynes - 1- yl) biphenyl -2- base] -1,3- dimethyl -1H- pyrazole-4-carboxamide (as known to WO2004/058723), (16.20) 2- be chloro- Pyridine-3-carboxamide is (by WO2004/058723 by N- [4'- (3- methoxyl group -3- methyl butyl- 1- alkynes -1- base) biphenyl -2- base] Know), (16.21) (the bromo- 2- methoxyl group -4- picoline -3- base of 5-) (2,3,4- trimethoxy -6- aminomethyl phenyl) ketone (by Known to EP-A1559320), (16.22) N- [2- (4- { [3- (4- chlorphenyl) propyl- 2- alkynes -1- base] oxygen } -3- methoxyphenyl) Ethyl]-N2- (methyl sulphonyl) valine amide (220706-93-4), (16.23) 4- oxygen -4- [(2- phenylethyl) amino] fourth Acid and (16.24) { 6- [({ [(Z)-(1- methyl-1 H- tetrazolium -5- base) (phenyl) methylene] amino } oxygroup) methyl] pyridine - 2- yl } carbamic acid butyl- 3- alkynes -1- ester, N- [9- (dichloromethylene) -1,2,3,4- tetrahydro -1,4- methanonaphthalene -5- base] - 3- (difluoromethyl) -1- methyl-1 H- pyrazole-4-carboxamide and 3- difluoromethyl -1- methyl-1 H- pyrazoles -4- carboxylic acid [2- (2, 18184- dichlorophenyl) -2- methoxyl group -1- methyl-ethyl]-amine.Wherein owning (1) to the blending constituent that (16) class is named can If optionally forming salt --- their functional group can be such with alkali appropriate or acid.

The bactericide that can be mentioned that has: bronopol (bronopol), antiphen (dichlorophen), N-Serve (nitrapyrin), Sankel (nickel dimethyldithiocarbamate), kasugarnycin (kasugamycin), pungent Thiophene ketone (octhilinone), furancarboxylic acid, terramycin (oxytetracyclin), probenazole (probenazole), streptomysin (streptomycin), tecloftalam (tecloftalam), copper sulphate and other copper agents.

Insecticide, acaricide and the nematicide that can be mentioned that have:

Acetylcholinesterase inhibitor, such as carbamates, for example, alanycarb (alanycarb), allyxycarb (allyxycarb), aminocarb (aminocarb), Ficam (bendiocarb), Benfuracard micro (benfuracarb), conjunction Kill prestige (bufencarb), butacarb (butacarb), butocarboxim (butocarboxim), butanone sulfone prestige (butoxycarboxim), carbaryl (carbaryl), carbosulfan (carbosulfan), cloethocarb (cloethocarb), dimetilan (dimetilan), ethiofencarb (ethiofencarb), Bassa (fenobucarb), benzene Sulphur prestige (fenothiocarb), Carzol (formetanate), furathiocarb (furathiocarb), Mobucin (isoprocarb), metham-sodium (metam-sodium), methiocarb (methiocarb), Methomyl (methomyl), MTMC (metolcarb), oxamyl (oxamyl), Aphox (pirimicarb), Carbamult (promecarb), arprocarb (propoxur), it thiodicarb (thiodicarb), thiofanox (thiofanox), Landrin (trimethacarb), XMC and goes out Kill prestige (xylylcarb)；Or organophosphorus compounds, such as orthene (acephate), azamethiphos (azamethiphos), azinphos-methyl (azinphos-methyl), triazotion (azinphos-ethyl), Rilariol (bromophos-ethyl), bromobenzene alkene phosphorus (bromfenvinfos (- methyl)), special Pyrimitate (butathiofos), sulphur line Phosphorus (cadusafos), carbophenothion (carbophenothion), chlorethoxyfos (chlorethoxyfos), chlorfenviphos (chlorfenvinphos), chlormephos (chlormephos), methyl/ethyl chlopyrifos (chlorpyrifos (- Methyl/-ethyl)), Resistox (coumaphos), Surecide (cyanofenphos), cynock (cyanophos), poisonous insect Fear (chlorfenvinphos), demeton-methyl (demeton-S-methyl), dioxydemeton-s-methyl (demeton-S- Methylsulfone), torak (dialifos), basudin (diazinon), dichlofenthion (dichlofenthion), hundred control Phosphorus (dicrotophos), Rogor (dimethoate), dimethylvinphos (dimethylvinphos), salithion (dioxabenzofos), disulfoton (disulfoton), phenothiazide (EPN), Ethodan (ethion), phonamiphos (ethoprophos), oxygen Diothyl (etrimfos), famphur (famphur), fenamiphos (fenamiphos), fenifrothion (fenitrothion), fensulfothion (fensulfothion), Entex (fenthion), flupyrazofos, Dyfonate (fonofos), pacify fruit (formothion), fosmethilan (fosmethilan), thiazolone phosphorus (fosthiazate), heptenophos (heptenophos), iodfenphos (iodofenphos), different rice blast net (iprobenfos), isazofos (isazofos), different willow Phosphorus (isofenphos), O- isopropyl salicylate, oxazoline (isoxathion), malathion (malathion), Afos (mecarbam), methacrifos (methacrifos), acephatemet (methamidophos), methidathion (methidathion), speed Go out phosphorus (mevinphos), Azodrin (monocrotophos), 2-dichloroethylk dimethyl phosphate (naled), flolimat (omethoate), sulfoxide Phosphorus (oxydemeton-methyl), methyl/ethyl parathion (parathion (- methyl/-ethyl)), phenthoate dimephenthoate cidial (phenthoate), Phosalone (phosalone), phosmet (phosmet), phosphamidon (phosphamidon), the third phosphorus of second Prestige (phosphocarb), phoxim (phoxim), Actellic (pirimiphos (- methyl/-ethyl)), Profenofos (profenofos), Kayaphos (propaphos), propetamphos (propetamphos), Toyodan (prothiofos), Fac (prothoate), pyraclofos (pyraclofos), pyridaphethione (pyridaphenthion), pyridathion, diethquinalphione (quinalphos), cadusafos (sebufos), sulfotep (sulfotep), second Toyodan (sulprofos), butyl pyrimidine phosphorus (te bu pi rimf os), Swebate (teme phos), terbufos (te r buf os), Ravap (tetrachlorvinphos), thiometon (thiometon), Hostathion (triazophos), metrifonate (triclorfon), vamidothion (vamidothion) and imicyafos.

The controlled chloride channel antagonists of GABA, such as organochlorine class, such as toxaphene (camphechlor), Niran (chlordane), 5a,6,9,9a-hexahydro-6,9-methano-2,4 (endosulfan), lindane (gamma-HCH), six six six (HCH), heptachlor (heptachlor), woods Red (lindane) and methoxychlor (methoxychlor)；Or Phenylpyrazole (fiprole) class, such as acetoprole, second Worm nitrile (ethiprole), Fipronil (fipronil), pyrazine Fipronil (pyrafluprole), pyriprole and vaniliprole。

Sodium channel modulators/potential dependent (voltage-dependent) sodium channel blockers (blocker), such as Pyrethroid, such as acrinathrin (acrinathrin), allethrin (d- is cis- anti-, and d- is anti-) (allethrin (d- Cis-trans, d-trans)), β-cyfloxylate (beta-cyfluthrin), Biphenthrin (bifenthrin), biological alkene Third pyrethroids (bioallethrin), bioallethrin-S- cyclopenta isomers, bioethanomethrin, biopermethrin (biopermethrin), bioresmethrin (bioresmethrin), chlovaporthrin, alphamethrin (cis- Cypermethrin), cis- resmethrin (cis-resmethrin), cis- Permethrin (cis-permethrin), Clocythrin, cycloprothrin (cycloprothrin), cyfloxylate (cyfluthrin), lambda-cyhalothrin (cyhalothrin), cypermethrin (α-, β-, θ-, ζ -) (cypermethrin (alpha-, beta-, theta-, Zeta-)), cyphenothrin (cyphenothrin), decis (deltamethrin), Prallethrin ((1R)-isomers) (empenthrin ((1R)-isomer)), S- fenvalerate (esfenvalerate), ethofenprox (etofenprox), phenyl-pentafluoride Pyrethroids (fenfluthrin), Fenpropathrin (fenpropathrin), fenpyrithrin, fenvalerate (fenvalerate), Flubrocythrinate, flucythrinate (flucythrinate), the third benzyl oxide of fluorine (flufenprox), flumethrin (flumethrin), taufluvalinate (fluvalinate), fubfenprox, gamma-cyhalothrin (gamma- Cyhalothrin), miaow alkynes pyrethroids (imiprothrin), kadethrin (kadethrin), λ-lambda-cyhalothrin (lambda- Cyhalothrin), metofluthrin (metofluthrin), Permethrin (cis/trans) (permethrin(cis-rans)), Phenothrin ((1R)-transisomer) (phenothrin (1R-trans-isomer)), prallethrin (prallethrin), the third Flumethrin (profluthrin), protrifenbute, anti-Chryson (pyresmethrin), benzyl furan Pyrethroids (resmethrin), kadethrin (RU15525), silafluofene (silafluofen), τ-taufluvalinate (tau- Fluvalinate), Tefluthrin (tefluthrin), terallethrin (terallethrin), tetramethrin ((1R)-isomery Body) (tetramethrin (1R)-isomer), tralomethrin (tralomethrin), transfluthrin (transfluthrin), brofluthrinate (ZXI8901), pyrethrin (pyrethrin (pyrethrum)), eflusilanat；DDT；Or methoxychlor (methoxychlor).

Acetyl choline receptor agonists/antagonist, such as chlorine nicotine base class (chloronicotinyls), for example, pyridine worm Amidine (acetamiprid), clothianidin (clothianidin), dinotefuran (dinotefuran), imidacloprid (imidacloprid), imidaclothiz, Nitenpyram (nitenpyram), Nithiazine (nithiazine), thiacloprid (thiacloprid), Diacloden (thiamethoxam), AKD-1022；Or nicotine (nicotine), bensultap (bensultap), cartap (cartap), dimehypo (thiosultap-sodium) and thiocyclam (thiocylam).

Allosteric type acetylcholine receptor modulators (agonist), such as multiple killing teichomycin class (spinosyns), such as more sterilizations Plain (spinosad) and spinetoram.

Chloride channel activators, for example, mectins/ macrolides, such as avermectin (abamectin),

Emaricin (emamectin), emaricin benzoate (emamectinbenzoate), Olivomitecidin (ivermectin), lepimectin and Mir's bud rhzomorph (milbemycin)；Or juvenile hormone mimics (juvenile ), such as hydroprene (hydroprene), kinoprene (kinoprene), methoprene hormoneanalogues (methoprene), young ether (epofenonane), sulphur olefin(e) acid ester (triprene), fenoxycarb (fenoxycarb), Nylar are protected (pyriproxyfen) and luxuriant ether (diofenolan) is disliked.

The unknown or non-specific active constituent of the mechanism of action, such as gas generating agent, such as bromomethane, chloropicrin (chloropicrin) and vikane (sulfuryl fluoride)；Selective antifeedant, such as ice crystal (cryolite), Pymetrozine (pymetrozine), pyrifluquinazon, flonicamide, double third ring worm esters；Or mite growth inhibitor, example Such as clofentezine (clofentezine) Hexythiazox (hexythiazox), etoxazole (etoxazole).

Oxidative phosphorylation inhibitors class, ATP agent interfering, such as diafenthiuron (diafenthiuron)；Organo-tin compound, Such as azacyclotin (azocyclotin), plictran (cyhexatin) and fenbutatin oxide (fenbutatin oxide)；Or propargite (propargite), tetradiphon (tetradifon).

The oxidative phosphorylation uncoupler class to be worked by being interrupted H- proton gradient, such as capillary (chlorfenapyr), binapacryl (binapacyrl), enemy completely logical (dinobuton), dinocap (dinocap) and elgetol (DNOC).

Insect gut membrane micro agent interfering, such as bacillus thuringiensis (Bacillus thuringiensis) bacterium Strain.

Benzoylurea derivertives class, such as benzoyl area kind, such as double trifluoros Worm urea (bistrifluron), chlorfluazuron (chlofluazuron), diflubenzuron (diflubenzuron), fluorine fluazuron (fluazuron), flucycloxuron (flucycloxuron), flufenoxuron (flufenoxuron), flubenzuron (hexaflumuron), Lufenuron (lufenuron), novaluron (novaluron), noviflumuron (noviflumuron), penfluron (penfluron).

Husking interferon, such as cyromazine (cyromazine).

Ecdysone agonist/agent interfering class, such as diacyl hydrazine, such as ring worm Hydrazides (chromafenozide), chlorine tebufenozide (halofenozide), methoxyfenozide (methoxyfenozide), worm acyl Hydrazine (tebufenozide) and furan tebufenozide (fufenozide, JS118)；Or nimbin (azadirachtin).

Octopaminergic agonist class, such as Amitraz (amitraz).

Site III electron transfer inhibitors class/site II electron transfer inhibitors class, such as amdro (hydramethylnone), acequinocyl (acequinocyl), fluacrypyrim (fluacrypyrim)；Or cyflumetofen (cyflumetofen) and cyenopyrafen.

Electron transfer inhibitors class, such as site I electron transfer inhibitors class, METI acaricide, for example, fenazaquin (fenazaquin), fenpyroximate (fenpyroximate), pyrimidifen (pyrimidifen), pyridaben (pyridaben), pyrrole mite Amine (tebufenpyrad), Tolfenpyrad (tolfenpyrad) and rotenone (rotenone)；Or potential dependent (voltage-dependent) sodium channel blockers, such as indoxacarb (indoxacarb) and metaflumizone (metaflumizone).

Fatty acid biological synthetic inhibitor, such as tetronic acid (tetronic acid) derivative, such as Envidor (spirodiclofen) and Spiromesifen (spiromesifen)；Or tetramic acid (tetramic acid) derivative, example Such as spiral shell worm ethyl ester (spirotetramat).

The unknown neuron inhibitor of the mechanism of action, such as Bifenazate (bifenazate).

Ryanodine (ryanodine) receptor stimulating agent, such as diamides, such as Flubendiamide (flubendiamide), (R), the chloro- N1- of (S)-3- { 2- methyl-4- [1,2,2,2- tetra- fluoro- 1- (trifluoromethyl) ethyl] phenyl }-N 2-(1- methyl- 2- methysulfonylethyl) phthalic amide, Rynaxypyr (chlorantraniliprole (Rynaxypyr)) or Bromine cyanogen insect amide (Cyantraniliprole (Cyazypyr)).

The unknown active constituent of other mechanisms of action, such as amidoflumet, benclothiaz, benzoximate, bromine Mite ester (bromopropylate), Buprofezin (buprofezin), quinomethionate (chinomethionat), Spanon (chlorodimeform), chlorfenizon (chlorobenzilate), clothiazoben, cycloprene, dicofol (dicofol), dicyclanil, fenoxacrim, fluorine nitre diphenylamines (fentrifanil), thiazole mite (flubenzimine), Flufenerim, flutenzin, gossyplure (gossyplure), japonilure, metoxadiazone (metoxadiazone), Dormant oil (petroleum), potassium oleate, pyridalyl (pyridalyl), sulfluramid (sulfluramid), Diphenylsulfide (tetrasul), benzene match mite (triarathene) or verbutin.

The invention has the following beneficial effects:

1, trifloxystrobin and 8-hydroxyquinoline composition are in certain mass number proportional region to phytopathogen such as cucumber target spot Sick pathogen melon stick spore bacterium (Corynespora cassiicola(Berk.&Curt.) Wei.) mycelia growth have collaboration increase Effect effect.

2, the composition that the salt of trifloxystrobin and 8-hydroxyquinoline is formed is in certain mass number proportional region to phytopathy Opportunistic pathogen such as Leaf Spot Caused by Corynespora cassiicola on Cucumber pathogen melon stick spore bacterium (Corynespora cassiicola (Berk.&Curt.) Wei.) bacterium Silk growth has synergistic function.

Specific embodiment

According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association Same antagonism, 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index (ATI)=(EC of standard agent₅₀The EC of/reagent agent₅₀) × 100；The toxicity index of theoretical toxicity index TTI=A medicament × mixed In agent in toxicity index × mixture of the percentage composition+B medicament of A medicament B medicament percentage composition；Co-toxicity coefficient (CTC)=[mixed Agent survey toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100.

Embodiment one: trifloxystrobin and 8-hydroxyquinoline to melon stick spore bacterium (Corynespora cassiicola (Berk.& Curt.) Wei.) indoor toxicity test, subjects pick up from the pathogen melon stick spore bacterium of the Leaf Spot Caused by Corynespora cassiicola on Cucumber in field (Corynespora cassiicola (Berk.&Curt.) Wei.).

Table 1: trifloxystrobin and 8-hydroxyquinoline to melon stick spore bacterium (Corynespora cassiicola (Berk.&Curt.) Wei. The Toxicity Determination result).

Reagent agent	Proportion	EC50(ug/ml)	ATI	TTI	CTC
						Trifloxystrobin	-	4.525	100.00
8-hydroxyquinoline	-	34.668	13.05
						Trifloxystrobin: 8-hydroxyquinoline	30:1	4.113	110.02	97.20	113.19
Trifloxystrobin: 8-hydroxyquinoline	20:1	3.726	121.44	95.86	126.69
						Trifloxystrobin: 8-hydroxyquinoline	15:1	3.371	134.23	94.57	141.95
Trifloxystrobin: 8-hydroxyquinoline	10:1	3.114	145.31	92.10	157.78
						Trifloxystrobin: 8-hydroxyquinoline	5:1	3.036	149.04	85.51	174.30
Trifloxystrobin: 8-hydroxyquinoline	2:1	3.285	137.75	71.02	193.96
						Trifloxystrobin: 8-hydroxyquinoline	1:1	3.681	122.93	56.53	217.47
Trifloxystrobin: 8-hydroxyquinoline	1:2	4.773	94.80	42.03	225.54
						Trifloxystrobin: 8-hydroxyquinoline	1:5	7.848	57.66	27.54	209.33
Trifloxystrobin: 8-hydroxyquinoline	1:10	11.669	38.78	20.96	185.04
						Trifloxystrobin: 8-hydroxyquinoline	1:20	18.472	24.50	17.19	142.48
Trifloxystrobin: 8-hydroxyquinoline	1:30	24.331	18.60	15.86	117.28
						Trifloxystrobin: 8-hydroxyquinoline	1:50	28.926	15.64	14.76	106.00
Trifloxystrobin: 8-hydroxyquinoline	1:70	31.447	14.39	14.28	100.79
						Trifloxystrobin: 8-hydroxyquinoline	1:90	35.328	12.81	14.01	91.44

As shown in Table 1, trifloxystrobin and 8-hydroxyquinoline mixture are between 20:1~1:20, to melon stick spore bacterium (Corynespora cassiicola (Berk.&Curt.) Wei.) there is apparent synergistic effect, co-toxicity coefficient is 120 More than.

Below with reference to embodiment to further instruction of the present invention.

Observation be actual observation to disease refer to preventive effect

Disease refers to preventive effect %)=×100。

Colby equation is used to determine desired effect (Colby, the S.R.Weeds1967,15,20- of mixture 22.Calculation of the synergistic and antagonistic response of herbicide Combinations):

Following equatioies are used to calculate the desired value of the mixture containing two kinds of active components A and B:

Desired value (E₀) ﹦ A+B-

In formula:

The effect of active components A of identical (dosage) concentration used in the mixture for A=observed；

The effect of active constituent B of identical (dosage) concentration used in the mixture for B=observed.

The active actual observation value (E) of the concentration (dosage) used in the mixture is greater than desired value (E₀) when, mixture is shown as There is unexpected synergistic effect to target.

Two 8-hydroxyquinoline trifloxystrobin water dispersible granule of embodiment

Weigh 50%8- oxyquinoline, 10% trifloxystrobin, 10% sodium lignin sulfonate, 3% chitosan, 2% tea seed cake powder, 1% sodium bicarbonate, Surplus white carbon black.Above-mentioned raw materials are uniformly mixed in mixed cylinder, and by extruding, granulation, drying, and screened step is made 50% 10% trifloxystrobin water dispersible granule of 8-hydroxyquinoline.

For table 2 for preventing and treating Leaf Spot Caused by Corynespora cassiicola on Cucumber, early stage is spraying, 15 days after medicine, E-E₀It is all larger than 20%.

Three copper 8-quinolinolate trifloxystrobin water suspending agent of embodiment

Copper 8-quinolinolate 24%, trifloxystrobin 12%, fatty alcohol polyoxyethylene ether 8%, castor oil polyoxyethylene ether 12%, sulfomethylated lignin Sour sodium 5%, urea 1%, glycerine 2%, deionized water carrier complement to 100%.Specific production stage are as follows: by effective component and other Auxiliary agent mixing forms high dispersive, stable suspension system after being sanded in high speed shear dispersion, sand mill in water-medium, The aqueous suspension agent of corresponding weight percentage is made.

For table 3 for preventing and treating Leaf Spot Caused by Corynespora cassiicola on Cucumber, early stage is spraying, 15 days after medicine, E-E₀It is all larger than 20%.

Bis- (8-hydroxyquinoline) the zinc trifloxystrobin water suspending agents of example IV

Bis- (8-hydroxyquinoline) zinc 20%, trifloxystrobin 10%, empgen BB 8%, EO-PO block polymer 5%, urea 1%, Glycerine 5%, deionized water carrier complement to 100%.Specific production stage are as follows: mix effective component and other auxiliary agents, through height After being sanded in speed shearing dispersion, sand mill, high dispersive, stable suspension system are formed in water-medium, corresponding weight is made The aqueous suspension agent of percentage composition.

Table 4 is for preventing and treating Leaf Spot Caused by Corynespora cassiicola on Cucumber, and early stage is spraying, 15 days after medicine.

Claims (10)

1. the composition based on 8-hydroxyquinoline, it is characterised in that: containing active constituent trifloxystrobin and 8-hydroxyquinoline, wherein oxime The mass fraction ratio of bacterium ester and 8-hydroxyquinoline is 20:1~1:20.

2. composition according to claim 1, it is characterised in that: trifloxystrobin and the mass fraction ratio of 8-hydroxyquinoline are 10:1~1:10.

3. composition according to claim 1, it is characterised in that: trifloxystrobin and the mass fraction ratio of 8-hydroxyquinoline are 5:1~1:5.

4. composition according to any one of claims 1 to 3, it is characterised in that: 8-hydroxyquinoline in the composition with The form of salt exists.

5. composition according to claim 4, it is characterised in that: 8-hydroxyquinoline is in the composition with aluminium salt, zinc salt, copper Salt form exists.

6. composition according to claim 5, it is characterised in that: 8-hydroxyquinoline is deposited in the form of mantoquita in the composition In specially copper 8-quinolinolate.

7. composition according to claim 5, it is characterised in that: 8-hydroxyquinoline is deposited in the composition with zinc salt forms In specially bis- (8-hydroxyquinoline) zinc.

8. composition according to any one of claims 1 to 3, it is characterised in that: the dosage form of the composition is that water is outstanding One of floating agent, dispersible oil-suspending agent, water dispersible granules, wettable powder.

9. composition described in claim 1~8 any one is used to prevent and treat the purposes in disease caused by the phytopathy original.

10. purposes according to claim 9, the plant disease is Leaf Spot Caused by Corynespora cassiicola on Cucumber.