CN109758372A - A kind of pellet and preparation method thereof with preparing the application in oral care product - Google Patents
A kind of pellet and preparation method thereof with preparing the application in oral care product Download PDFInfo
- Publication number
- CN109758372A CN109758372A CN201910001214.3A CN201910001214A CN109758372A CN 109758372 A CN109758372 A CN 109758372A CN 201910001214 A CN201910001214 A CN 201910001214A CN 109758372 A CN109758372 A CN 109758372A
- Authority
- CN
- China
- Prior art keywords
- pellet
- vegetable pill
- oral care
- toothpaste
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention relates to oral care techniques field more particularly to a kind of pellet and preparation method thereof with preparing the application in oral care product.Pellet partial size provided by the invention is 200~1200 μm.Comprising menthol, Paeonol, silibinin oil, vitamin C, vitamin E isoreactivity composition, it is coated with high molecular material.Pellet provided by the invention is stablized for a long time in toothpaste matrix, can be crushed completely during brushing teeth, and discharges functional component.It can be used for preparing the application in the oral care products such as toothpaste.
Description
Technical field
The present invention relates to oral care techniques fields more particularly to a kind of pellet and preparation method thereof to protect in preparation oral cavity
Manage the application in product.
Background technique
Toothpaste is to be used to clean tooth together with toothbrush, protects oral hygiene, a kind of daily necessities safe to the human body.
Toothpaste is complicated mixture, it is usually by a variety of originals such as rubbing agent, moisturizer, adhesive, foaming agent, preservative, sweetener
Material is mixed.Meanwhile in addition to the basis of toothpaste, more and more active matters are also added into toothpaste by people, are assigned
Toothpaste new function and efficiency.It bursts for example, such as vitamin, enzyme preparation, prevention oral cavity are often added in oral care implement
Rotten and swelling and aching of gum drug ingedient, fungicide etc..
But certain active constituent ingredients itself are unstable, it is easy to oxidize in the environment of normal temperature environment is contacted with air
Or it decomposes and loses activity；Or due to paste composition complexity, containing Multiple components and impurity, lead to active constituent and other groups
Divide reaction；Or in the Storage period of toothpaste, slow reaction occurs with the certain raw materials or impurity of toothpaste, stores toothpaste in shelf
When decay or rotten.
Therefore, when developing formulation of tooth-paste, except the function of focusing on toothpaste, the stability for considering active constituent is also needed, and
Can active material sufficiently be released when in use, to act on oral cavity.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is that providing a kind of pellet and preparation method thereof and preparing mouth
Application in chamber care product.Pellet provided by the invention can have good drugloading rate and stability, and can improve
Periodontal health situation.
Pellet provided by the invention is made of vegetable pill and the coatings being wrapped in outside vegetable pill；
The vegetable pill is by 10~50 mass parts of active component, 50~90 mass parts of filler, 0~2 mass parts group of adhesive
At；
The coatings are by 3~30 mass parts of hydrophobic polymeric material, 0~5 mass parts of plasticizer, 0~5 mass of antiplastering aid
Part composition.
In pellet provided by the invention, the mass ratio of the vegetable pill and the coating is 100:(3~40).
It further include 0~0.01 part of colorant in pellet provided by the invention, in the vegetable pill.
In the present invention, the active compound is in menthol, Paeonol, silibinin oil, vitamin C, vitamin E
One or more；
The filler is selected from one or more of microcrystalline cellulose, sucrose, starch, dextrin, lactose, mannitol；
Described adhesive be selected from polyvinylpyrrolidone, sodium carboxymethylcellulose, methylcellulose, hydroxypropyl cellulose,
One or more of hydroxypropyl methyl cellulose；
The hydrophobic polymeric material is selected from one or more of ethyl cellulose, cellulose acetate；
The plasticizer is selected from triethyl citrate, polyethylene glycol, triacetyl glycerine, citric acid ester, phthalic acid
One or more of ester；
The antiplastering aid is selected from one or more of talcum powder, superfine silica gel powder, magnesium stearate；
The colorant is selected from one or more of color lake, pigment.
In some embodiments, vegetable pill is made of 50 parts of active component, 50 parts of filler；
By 30 parts of hydrophobic polymeric material, 5 parts of plasticizer, 5 parts of antiplastering aid form coatings.
Active constituent is menthol and Paeonol.The mass ratio of menthol and Paeonol is 4:1.
Filler is microcrystalline cellulose and dextrin.The mass ratio of microcrystalline cellulose and dextrin is 4:1.
Hydrophobic polymeric material is ethyl cellulose, and plasticizer is triethyl citrate, and antiplastering aid is talcum powder.
In some embodiments, vegetable pill is made of 20 parts of active component, 78 parts of filler, 2 parts of adhesive；
Coatings are formed by 3 parts of hydrophobic polymeric material.
Active constituent is menthol and silibinin oil.The mass ratio of menthol and silibinin oil is 3:17.
Filler is microcrystalline cellulose and sucrose.The mass ratio of microcrystalline cellulose and sucrose is 70:8.
Adhesive is polyvinylpyrrolidone.
Hydrophobic polymeric material is ethyl cellulose.
In some embodiments, vegetable pill is made of 13 parts of active component, 87 parts of filler；
By 6 parts of hydrophobic polymeric material, 4 parts of plasticizer form coatings.
Active constituent is menthol and Paeonol.The mass ratio of menthol and Paeonol is 10:3.
Filler is microcrystalline cellulose.
Hydrophobic polymeric material is ethyl cellulose, and plasticizer is Macrogol 6000.
In some embodiments, vegetable pill is made of 34 parts of active component, 64.8 parts of filler, 1.2 parts of adhesive；
By 9 parts of hydrophobic polymeric material, 1 part of antiplastering aid forms coatings.
Active constituent is Paeonol and vitamin C.Paeonol and ascorbic mass ratio are 18:16.
Filler is microcrystalline cellulose and starch.The mass ratio of microcrystalline cellulose and starch is 24.8:40.
Adhesive is hydroxyethyl cellulose.
Hydrophobic polymeric material is cellulose acetate, and antiplastering aid is talcum powder.
In some embodiments, vegetable pill is made of 10 parts of active component, 90 parts of filler；
By 10 parts of hydrophobic polymeric material, 5 parts of plasticizer, 3 parts of antiplastering aid form coatings.
Active constituent is silibinin oil and vitamin E.The mass ratio of silibinin oil and vitamin E is 1:1.
Filler is microcrystalline cellulose and dextrin.The mass ratio of microcrystalline cellulose and dextrin is 62:28.
Hydrophobic polymeric material is ethyl cellulose, and plasticizer is Macrogol 6000, and antiplastering aid is superfine silica gel powder.
In some embodiments, vegetable pill is made of 46 parts of active component, 53 parts of filler, 1 part of adhesive；
By 10 parts of hydrophobic polymeric material, 3 parts of plasticizer, 3 parts of antiplastering aid form coatings.
Active constituent is menthol and vitamin C.Menthol and ascorbic mass ratio are 18:28.
Filler is microcrystalline cellulose, dextrin and lactose.The mass ratio of microcrystalline cellulose, dextrin and lactose is 32:8:13.
Adhesive is methylcellulose.
Hydrophobic polymeric material is ethyl cellulose, and plasticizer is phthalic acid ester, and antiplastering aid is magnesium stearate.
In some embodiments, vegetable pill is made of 33 parts of active component, 67 parts of filler；
Coatings are formed by 8 parts of hydrophobic polymeric material.
Active constituent is menthol, vitamin C and vitamin E.The mass ratio of menthol, vitamin C and vitamin E is
23:5:5。
Filler is microcrystalline cellulose, dextrin and mannitol.The mass ratio of microcrystalline cellulose, dextrin and mannitol is 48:
6:13。
Hydrophobic polymeric material is cellulose acetate.
In some embodiments, vegetable pill is made of 28 parts of active component, 71.999 parts of filler and 0.001 part of colorant；
By 6 parts of hydrophobic polymeric material, 2 parts of plasticizer form coatings.
Active constituent is Paeonol, silibinin oil and vitamin E.The quality of Paeonol, silibinin oil and vitamin E
Than for 13:2:13.
Filler is microcrystalline cellulose, starch, lactose.Microcrystalline cellulose, starch, lactose mass ratio be 25.999:30:
16.Colorant is copper chlorophyll pigment.
Hydrophobic polymeric material is acetate fiber, and plasticizer is citric acid ester.
In some embodiments, vegetable pill is made of 26 parts of active component, 73.8 parts of filler, 0.2 part of adhesive；
By 8 parts of hydrophobic polymeric material, 2 parts of plasticizer, 4 parts of antiplastering aid form coatings.
Active constituent is silibinin oil and vitamin C.Silibinin oil and ascorbic mass ratio are 1:1.
Filler is microcrystalline cellulose, starch and sucrose.Microcrystalline cellulose, starch and sucrose mass ratio be 26.8:30:
17。
Adhesive is hypromellose.
Hydrophobic polymeric material is ethyl cellulose, and plasticizer is triacetyl glycerine, and antiplastering aid is talcum powder.
In some embodiments, vegetable pill is made of 45 parts of active component, 54.7 parts of filler, adhesive 0.3g；
By 6 parts of hydrophobic polymeric material, 4 parts of antiplastering aid form coatings.
Active constituent is menthol and vitamin E.The mass ratio of menthol and vitamin E is 25:20.
Filler is microcrystalline cellulose and starch.The mass ratio of microcrystalline cellulose and starch is 31.7:23.
Adhesive is sodium carboxymethylcellulose.
Hydrophobic polymeric material is ethyl cellulose, and antiplastering aid is talcum powder.
In some embodiments, vegetable pill is made of 13 parts of active component, 86.99 parts of filler and 0.01 part of colorant；
By 6 parts of hydrophobic polymeric material, 4 parts of plasticizer form coatings.
Active constituent is menthol and Paeonol.The mass ratio of menthol and Paeonol is 10:3.
Filler is microcrystalline cellulose.Colorant is Brilliant blue aluminum lake；
Hydrophobic polymeric material is ethyl cellulose, and plasticizer is Macrogol 6000.
The preparation method of pellet provided by the invention includes:
The component of the vegetable pill and ethanol water are mixed and made into softwood；
Capsule core is made in the softwood by extrusion spheronization method, and drying, being sieved is made vegetable pill；
The component of the coatings is dissolved in ethyl alcohol as coating solution；
Fluidized coating method is coated the vegetable pill with the coating solution, and the pellet is made through drying.
In preparation method of the present invention, the rate of extrusion of the extrusion spheronization method is 10~40r/min, round as a ball rate
For 700~1400r/min, the round as a ball time is 1~10min.
In preparation method of the present invention, 25~40 DEG C of the coating temperature of the fluidized coating method, blower frequency 18~
35Hz, 0.1~0.2MPa of atomisation pressure, 5~30r/min of spray rate.
Application of the pellet of the present invention in the product of preparation oral care.
The present invention also provides a kind of products of oral care comprising matrix and pellet of the present invention.
In the present invention, the matrix of the toothpaste is grouped as by the group of following mass parts: glycerol, sorbierite, PEG400, card wave
Nurse, CMC, silica, saccharin sodium, xylitol, lauryl sodium sulfate, essence and water.
In the present invention, the toothpaste is grouped as by the group of following mass parts:
Pellet partial size provided by the invention is 200~1200 μm.Include menthol, Paeonol, silibinin oil, vitamin
C, vitamin E isoreactivity composition, is coated with high molecular material.Pellet provided by the invention is long-term steady in toothpaste matrix
It is fixed, it can be crushed completely during brushing teeth, discharge functional component.It can be used for preparing the application in the oral care products such as toothpaste.
Detailed description of the invention
The pellet toothpaste appearance of Fig. 1 preparation；
Fig. 2 simulation is brushed teeth；
During Fig. 3 brushes teeth, pellet rupture, functional component release.
Specific embodiment
The present invention provides a kind of pellet and preparation method thereof with preparing the application in oral care product., this field
Technical staff can use for reference present disclosure, be suitably modified realization of process parameters.In particular, it should be pointed out that all similar replacements
Apparent to those skilled in the art with changing, they are considered as being included in the present invention.Method of the invention
And application is described by preferred embodiment, related personnel can obviously not depart from the content of present invention, spirit and model
Enclose it is interior methods herein and application are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
The instrument that the present invention uses is all common commercially available product, can all be bought in market.
Below with reference to embodiment, the present invention is further explained:
Embodiment 1
(1) vegetable pill
Menthol 40g, Paeonol 10g, microcrystalline cellulose 40g, dextrin 10g are uniformly mixed, 50% ethyl alcohol softwood.Using
Extrusion spheronization method is 200 μm in hole diameter of sieve (perforated) plate, rate of extrusion 10r/min, round as a ball rate 1400r/min, round as a ball time 10min
Under conditions of be prepared into ball, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
Ethyl cellulose 30g, triethyl citrate 5g, talcum powder 5g is evenly dispersed in ethanol.Using fluidized bed bottom
Spray coating is wrapped under conditions of blower frequency 25HZ, coating 30 DEG C of temperature, atomisation pressure 0.2MPa, spray rate 20r/min
Clothing, continue dry 30min after the completion of coating can be used for the pellet (200 μm of partial size) of oral care to obtain the final product.
Embodiment 2
(1) vegetable pill
Menthol 3g, silibinin oil 17g, microcrystalline cellulose 70g, sucrose 8g, polyvinylpyrrolidone 2g, mixing are equal
It is even, 50% ethyl alcohol softwood.It is 1200 μm, rate of extrusion 40r/min in hole diameter of sieve (perforated) plate using extrusion spheronization method, round as a ball rate
Ball is prepared under conditions of 700r/min, round as a ball time 1min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
Ethyl cellulose 3g is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom, in blower frequency 35HZ, coating
It is coated under conditions of 40 DEG C of temperature, atomisation pressure 0.1MPa, spray rate 5r/min, continues dry 30min after the completion of coating i.e.
It must can be used for the pellet (1200 μm of partial size) of oral care.
Embodiment 3
(1) vegetable pill
Menthol 10g, Paeonol 3g, microcrystalline cellulose 87g are uniformly mixed, 40% ethyl alcohol softwood.Using extrusion spheronization
Method is 700 μm in hole diameter of sieve (perforated) plate, makes under conditions of rate of extrusion 25r/min, round as a ball rate 850r/min, round as a ball time 3min
Standby ball, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
By ethyl cellulose 6g, Macrogol 6000 4g it is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom,
It is coated, has been coated under conditions of blower frequency 18HZ, 25 DEG C of temperature of coating, atomisation pressure 0.16MPa, spray rate 15r/min
Continue dry 30min at rear and can be used for the pellet (700 μm of partial size) of oral care to obtain the final product.
Embodiment 4
(1) vegetable pill
Paeonol 18g, vitamin C 16g, microcrystalline cellulose 24.8g, starch 40g, hydroxypropyl cellulose 1.2g mixing are equal
It is even, 40% ethyl alcohol softwood.It is 500 μm, rate of extrusion 32r/min in hole diameter of sieve (perforated) plate using extrusion spheronization method, round as a ball rate
Ball is prepared under conditions of 900r/min, round as a ball time 2.5min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
By cellulose acetate 9g, talcum powder 1g it is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom, in blower frequency
Rate 20HZ, 35 DEG C of temperature of coating, atomisation pressure 0.16MPa, be coated under conditions of spray rate 10r/min, after the completion of coating after
Continuous dry 30min can be used for the pellet (500 μm of partial size) of oral care to obtain the final product.
Embodiment 5
(1) vegetable pill
Silibinin oil 5g, vitamin E 5g, microcrystalline cellulose 62g, dextrin 28g are uniformly mixed, 40% ethyl alcohol softwood.
It is 800 μm, the round as a ball rate 1100r/min of rate of extrusion 15r/min in hole diameter of sieve (perforated) plate using extrusion spheronization method, the round as a ball time
Ball is prepared under conditions of 1.5min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
By ethyl cellulose 10g, Macrogol 6000 5g, superfine silica gel powder 3g it is evenly dispersed in ethanol.Using fluidisation
Bed bottom spray coating, under conditions of blower frequency 23HZ, coating 30 DEG C of temperature, atomisation pressure 0.12MPa, spray rate 8r/min
Coating, continue dry 30min after the completion of coating can be used for the pellet (800 μm of partial size) of oral care to obtain the final product.
Embodiment 6
(1) vegetable pill
Menthol 18g, Catergen 8g, microcrystalline cellulose 32g, dextrin 8g, lactose 13g, methylcellulose 1g mixing are equal
It is even, 40% ethyl alcohol softwood.It is 800 μm, rate of extrusion 20r/min in hole diameter of sieve (perforated) plate using extrusion spheronization method, round as a ball rate
Ball is prepared under conditions of 750r/min, round as a ball time 8min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
By ethyl cellulose 10g, phthalic acid ester 3g, magnesium stearate 3g it is evenly dispersed in ethanol.Using fluidized bed
Bottom spray coating is wrapped under conditions of blower frequency 23HZ, coating 33 DEG C of temperature, atomisation pressure 0.12MPa, spray rate 8r/min
Clothing, continue dry 30min after the completion of coating can be used for the pellet (800 μm of partial size) of oral care to obtain the final product.
Embodiment 7
(1) vegetable pill
Menthol 23g, vitamin C 5g, vitamin E 5g, microcrystalline cellulose 48g, dextrin 6g, mannitol 13g are uniformly mixed,
40% ethyl alcohol softwood.It is 400 μm, rate of extrusion 18r/min in hole diameter of sieve (perforated) plate using extrusion spheronization method, round as a ball rate
Ball is prepared under conditions of 1300r/min, round as a ball time 4min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
Cellulose acetate 8g is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom, in blower frequency 20HZ, coating
It is coated under conditions of 30 DEG C of temperature, atomisation pressure 0.14MPa, spray rate 10r/min, continues dry 30min after the completion of coating
It can be used for the pellet (400 μm of partial size) of oral care to obtain the final product.
Embodiment 8
(1) vegetable pill
Paeonol 13g, silibinin oil 2g, vitamin e1 3g, microcrystalline cellulose 25.999g, starch 30g, lactose 16g,
0.001g copper chlorophyll pigment is uniformly mixed, 40% ethyl alcohol softwood.Using extrusion spheronization method, it is 400 μm in hole diameter of sieve (perforated) plate, squeezes
Ball is prepared under conditions of rate 23r/min out, round as a ball rate 1100r/min, round as a ball time 6min, up to element after drying and screening
Ball.
(2) hydrophobic layer is coated
Cellulose acetate 6g, citric acid ester 2g is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom, in blower frequency
Rate 21HZ, 35 DEG C of temperature of coating, atomisation pressure 0.14MPa, be coated under conditions of spray rate 10r/min, after the completion of coating after
Continuous dry 30min can be used for the pellet (400 μm of partial size) of oral care to obtain the final product.
Embodiment 9
(1) vegetable pill
Silibinin oil 13g, vitamin C 13g, microcrystalline cellulose 26.8g, starch 30g, sucrose 17g, hydroxypropyl methylcellulose
Plain 0.2g is uniformly mixed, 40% ethyl alcohol softwood.It is 600 μm in hole diameter of sieve (perforated) plate using extrusion spheronization method, rate of extrusion 33r/
Ball is prepared under conditions of min, round as a ball rate 1200r/min, round as a ball time 3min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
Ethyl cellulose 8g, triacetyl glycerine 2g, talcum powder 4g is evenly dispersed in ethanol.It is sprayed using fluidized bed bottom
Coating is coated under conditions of blower frequency 20HZ, coating 30 DEG C of temperature, atomisation pressure 0.18MPa, spray rate 12r/min,
Continue dry 30min after the completion of coating can be used for the pellet (600 μm of partial size) of oral care to obtain the final product.
Embodiment 10
(1) vegetable pill
Menthol 25g, vitamin E2 0g, microcrystalline cellulose 31.7g, starch 23g, sodium carboxymethylcellulose 0.3g mixing are equal
It is even, 40% ethyl alcohol softwood.It is 1000 μm, rate of extrusion 14r/min in hole diameter of sieve (perforated) plate using extrusion spheronization method, round as a ball rate
Ball is prepared under conditions of 800r/min, round as a ball time 8min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
Ethyl cellulose 6g, talcum powder 4g is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom, in blower frequency
It is coated under conditions of 18HZ, 30 DEG C of temperature of coating, atomisation pressure 0.12MPa, spray rate 7r/min, continues to do after the completion of coating
Dry 30min can be used for the pellet (1000 μm of partial size) of oral care to obtain the final product.
Embodiment 11
(1) vegetable pill
Menthol 10g, Paeonol 3g, microcrystalline cellulose 86.99g, Brilliant blue aluminum lake 0.01g are uniformly mixed, 40% ethyl alcohol
Softwood processed.It is 700 μm in hole diameter of sieve (perforated) plate using extrusion spheronization method, rate of extrusion 25r/min, round as a ball rate 850r/min is round as a ball
Ball is prepared under conditions of time 3min, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
By ethyl cellulose 6g, Macrogol 6000 4g it is evenly dispersed in ethanol.It is sprayed and is coated using fluidized bed bottom,
It is coated, has been coated under conditions of blower frequency 20HZ, 25 DEG C of temperature of coating, atomisation pressure 0.16MPa, spray rate 15r/min
Continue dry 30min at rear and can be used for the pellet (700 μm of partial size) of oral care to obtain the final product.
Comparative example 1
(1) vegetable pill
Menthol 10g, Paeonol 3g, microcrystalline cellulose 87g are uniformly mixed, 40% ethyl alcohol softwood.Using extrusion spheronization
Method is prepared under conditions of blower frequency 19HZ, rate of extrusion 25r/min, round as a ball rate 850r/min, round as a ball time 3min
Ball, up to vegetable pill (700 μm of partial size) after drying and screening.
Comparative example 2
(1) vegetable pill
Menthol 10g, Paeonol 3g, microcrystalline cellulose 87g are uniformly mixed, 40% ethyl alcohol softwood.Using extrusion spheronization
Method is 700 μm in hole diameter of sieve (perforated) plate, makes under conditions of rate of extrusion 25r/min, round as a ball rate 850r/min, round as a ball time 3min
Standby ball, up to vegetable pill after drying and screening.
(2) hydrophobic layer is coated
Hydroxypropyl methyl cellulose 6g is evenly dispersed in water.Using fluidized bed bottom spray be coated, blower frequency 20HZ,
It is coated under conditions of 35 DEG C of temperature of coating, atomisation pressure 0.16MPa, spray rate 10r/min, continues drying after the completion of coating
30min can be used for the pellet (700 μm of partial size) of oral care to obtain the final product.
Embodiment 12
Appropriate embodiment 1~11, comparative example 1,2 gained pellet of comparative example are taken, is contained using gas chromatography measurement menthol
Amount detects pellet angle of repose and disintegration in water using liquid chromatography for measuring paeonol content, and according to pharmacopoeial requirements
Energy.
1 pellet drugloading rate of table and form are investigated
As shown in Table 1, uncoated vegetable pill drugloading rate is high, and good fluidity, friability is low, has good hardness, and
Disintegration rate is fast.In each embodiment, in terms of yield, the yield of embodiment 2 and comparative example 1 connects higher.In all embodiments, implement
The yield highest of example 2.In terms of mobility, the best conspicuousness of pellet mobility made from embodiment 1 is better than other embodiments system
The pellet obtained, p < 0.05.In terms of friability, the friability that pellet is made in embodiment 1 is minimum, and conspicuousness is better than other embodiments
Pellet obtained, p < 0.05.
Embodiment 13~25
Appropriate embodiment 1~11, comparative example 1,2 gained pellet of comparative example are taken, it is straight under normal temperature state using one-step method cream
It connects and various component water mill liniments, adhesive, moisturizer, foaming agent is sequentially put into Manufacturing medicine extract machine, under vacuum outgas state, by strong
The stirring of power, makes the fully dispersed mixing of each component, and simultaneous grinding homogeneous is eventually adding essence, preservative and can be used for oral cavity
The pellet of nursing stirs evenly the toothpaste up to each embodiment.
2 pellet toothpaste prescription of table and its form
As shown in Table 2, after toothpaste being made, in the toothpaste of embodiment 13~14, pellet is completely suspended in matrix.And implement
Pellet largely ruptures in the toothpaste of example 24, in the toothpaste of embodiment 25, pellet partial rupture.Illustrate using comparative example 1, comparison
Pellet made from example 2 largely ruptures in toothpaste preparation process, can not completely be stored in matrix.
According to commercially available back, using menthol content as inspection target, low temperature, length are carried out to the toothpaste of embodiment 13~25
Phase, accelerated stability are investigated.As a result such as table 3:
3 pellet toothpaste study on the stability of table
Active material is prepared into pellet using 1~11 method of embodiment, content be basically unchanged in study on the stability or
Variation is less, highly stable.
Embodiment 26
Pellet toothpaste is made in Example 23.It carries out simulation to brush teeth, observation pellet is crushed situation.As a result as shown in Figures 1 to 3
By Fig. 1~3 it is found that pellet can be uniformly mixed with toothpaste matrix, and pellet is not broken up.The 2min that brushes teeth is simulated, it is micro-
Ball can be crushed completely, discharge functional component.
Embodiment 27
Selection 18-50 years old simple gingivitis patient 20, be randomly divided into test group and control group each 10, referred to gum
Number (GI), gingival sulcus bleeding index (SBI) are come the effect of evaluating pellet toothpaste.Experimental group is that pellet toothpaste is made in embodiment 15, right
It is the toothpaste of without effect ingredient according to group.
(1) gingival index (GI)
It using blunt nosed periodontal probe, is examined in conjunction with visual examination and spy, checks denture.It must check every periodontal tooth
Gum by closely middle lip (cheek) nipple of its surrounding gum atmosphere, center lip (cheek) edge, remote middle lip (cheek) nipple and lingual gingiva edge, and is pressed
The score value of each facing of following standard recordings 4.The average value scored for 4 facings of scoring of every tooth, everyone scores as whole
The average value scored by inspection tooth.
Scoring criteria
0=gums healthy
1=gum mild inflammation: gingiva color has mild change and oedema, and not bleeding is examined in spy
2=gum moderate inflammation: gum color is red, and oedema is bright, and bleeding is examined in spy
3=gum extensive inflammation: gum is obvious red and swollen or has ulcer, and has automatic hemorrhagic tendency (2) gingival sulcus bleeding index
(SBI)
Using visual examination in conjunction with the method examined is visited, using blunt nosed periodontal probe, gently visit gingival sulcus (spy examines strength in 20g or less),
Check denture.Probe and facing at 45 degree of angles, along gum edge gently from tooth tongue side or cheek side it is remote in detect in close, keep away
Exempt from deep spy.
Scoring criteria
0=gum edge and gum nipple healthy appearance, light not bleeding after visiting gingival sulcus
1=gum edge and gum nipple are in mild inflammation, light not bleeding after visiting gingival sulcus
2=gum is in mild inflammation, there is color change, no swelling or oedema, and rear petechial hemorrhage is examined in spy
3=gum is in moderate inflammation, there is color change and Mild edema, and rear bleeding is examined in spy, and blood overflows in gingival sulcus
4=gum is in hyperphlogosis, not only has color change, and have obvious tumefaction, and rear bleeding is examined in spy, and blood overflows gingival sulcus
5=gum has color change, hence it is evident that swelling has ulcer sometimes, and rear bleeding or automatic bleeding experimental result are examined in spy:
Table 4 uses the comparison of periodontal index variation before toothpaste
Compared with blank group, #P < 0.05, ##P < 0.05
Compared with before edible toothpaste, * P < 0.05, * * P < 0.01；1
Control group subject uses toothpaste 4 weeks, and gingival sulcus bleeding index and gingival index are without significant compared with using before toothpaste
Sex differernce.Experimental group subject has height compared with using before toothpaste using toothpaste 4 weeks, gingival sulcus bleeding index, gingival index decline
Spend significant difference.The effect of illustrating that the toothpaste containing pellet has apparent protection gum, preventing bleeding gums.
The above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of pellet is made of vegetable pill and the coatings being wrapped in outside vegetable pill；
The vegetable pill is made of 10~50 mass parts of active component, 50~90 mass parts of filler, 0~2 mass parts of adhesive；
The coatings are by 3~30 mass parts of hydrophobic polymeric material, 0~5 mass parts of plasticizer, 0~5 mass parts group of antiplastering aid
At；
The active compound is selected from one or more of menthol, Paeonol, silibinin oil, vitamin C, vitamin E；
The hydrophobic polymeric material is selected from one or more of ethyl cellulose, cellulose acetate.
2. pellet according to claim 1, which is characterized in that the mass ratio of the vegetable pill and the coating be 100:(3~
40)。
3. pellet according to claim 1, which is characterized in that further include 0~0.01 part of colorant in the vegetable pill.
4. pellet according to claim 1, which is characterized in that
The filler is selected from one or more of microcrystalline cellulose, sucrose, starch, dextrin, lactose, mannitol；
Described adhesive is selected from polyvinylpyrrolidone, sodium carboxymethylcellulose, methylcellulose, hydroxypropyl cellulose, hydroxypropyl
One or more of ylmethyl cellulose；
The plasticizer is in triethyl citrate, polyethylene glycol, triacetyl glycerine, citric acid ester, phthalic acid ester
One or more；
The antiplastering aid is selected from one or more of talcum powder, superfine silica gel powder, magnesium stearate；
The colorant is selected from one or more of color lake, pigment.
5. the preparation method of any one of Claims 1 to 4 pellet, comprising:
The component of the vegetable pill and ethanol water are mixed and made into softwood；
Capsule core is made in the softwood by extrusion spheronization method, and drying, being sieved is made vegetable pill；
The component of the coatings is dissolved in ethyl alcohol as coating solution；
Fluidized coating method is coated the vegetable pill with the coating solution, and the pellet is made through drying.
6. preparation method according to claim 5,
The hole diameter of sieve (perforated) plate of the extrusion spheronization method is 200~1200 μm, and rate of extrusion is 10~40r/min, and round as a ball rate is 700
~1400r/min, round as a ball time are 1~10min；
18~35Hz of blower frequency of the fluidized coating method, coating 25~40 DEG C of temperature, 0.1~0.2MPa of atomisation pressure, spray
5~30r/min of mist rate.
7. prepared by pellet made from the described in any item pellets of Claims 1 to 4 or the preparation method of claim 5 or 6
Application in the product of oral care.
8. a kind of product of oral care, which is characterized in that including matrix and the described in any item pellets of Claims 1 to 4, or
Pellet made from the preparation method of claim 5 or 6.
9. product according to claim 8, which is characterized in that the product of the oral care is toothpaste, mouthwash, mouth perfume
One or more of sugar.
10. product according to claim 9, which is characterized in that the matrix of the toothpaste is grouped by the group of following mass parts
At: glycerol, sorbierite, PEG400, carbomer, CMC, silica, saccharin sodium, xylitol, lauryl sodium sulfate, essence and
Water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910001214.3A CN109758372A (en) | 2019-01-02 | 2019-01-02 | A kind of pellet and preparation method thereof with preparing the application in oral care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910001214.3A CN109758372A (en) | 2019-01-02 | 2019-01-02 | A kind of pellet and preparation method thereof with preparing the application in oral care product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109758372A true CN109758372A (en) | 2019-05-17 |
Family
ID=66453399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910001214.3A Pending CN109758372A (en) | 2019-01-02 | 2019-01-02 | A kind of pellet and preparation method thereof with preparing the application in oral care product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109758372A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478304A (en) * | 2019-08-20 | 2019-11-22 | 广州市金熊大健康科技有限公司 | A kind of toothpaste containing bear gall microcapsules |
| CN110974719A (en) * | 2019-12-26 | 2020-04-10 | 东莞波顿香料有限公司 | Vitamin E sustained-release granules, preparation method thereof and washing and caring product |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1486706A (en) * | 1974-11-26 | 1977-09-21 | Johnson & Johnson | Flavoured dental cleaning articles |
| CN1311658A (en) * | 1998-06-04 | 2001-09-05 | 高露洁-棕榄公司 | Dentifrice composition contg. encapsulated reactive ingredients |
| CN102908319A (en) * | 2012-11-09 | 2013-02-06 | 东北制药（沈阳）科技发展有限公司 | Vitamin C sustained-release pellets and method for preparing same |
| CN103813717A (en) * | 2011-04-21 | 2014-05-21 | 洲际大品牌有限责任公司 | Improved stability of peroxide in oral care compositions |
| CN105012173A (en) * | 2015-07-09 | 2015-11-04 | 常州艾瑞特电子有限公司 | Toothpaste for preventing and treating oral ulcer and preparation method thereof |
| CN106729656A (en) * | 2016-12-07 | 2017-05-31 | 江山 | A kind of oral care composition for treating dry and its application in toothpaste |
-
2019
- 2019-01-02 CN CN201910001214.3A patent/CN109758372A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1486706A (en) * | 1974-11-26 | 1977-09-21 | Johnson & Johnson | Flavoured dental cleaning articles |
| CN1311658A (en) * | 1998-06-04 | 2001-09-05 | 高露洁-棕榄公司 | Dentifrice composition contg. encapsulated reactive ingredients |
| CN103813717A (en) * | 2011-04-21 | 2014-05-21 | 洲际大品牌有限责任公司 | Improved stability of peroxide in oral care compositions |
| CN102908319A (en) * | 2012-11-09 | 2013-02-06 | 东北制药（沈阳）科技发展有限公司 | Vitamin C sustained-release pellets and method for preparing same |
| CN105012173A (en) * | 2015-07-09 | 2015-11-04 | 常州艾瑞特电子有限公司 | Toothpaste for preventing and treating oral ulcer and preparation method thereof |
| CN106729656A (en) * | 2016-12-07 | 2017-05-31 | 江山 | A kind of oral care composition for treating dry and its application in toothpaste |
Non-Patent Citations (5)
| Title |
|---|
| 周德生等: "《单味药方治百病》", 30 September 2016, 山西科学技术出版社 * |
| 孟胜男: "《药剂学》", 31 January 2012, 上海科学技术出版社 * |
| 本刊讯: ""一种新型日化用品制剂——牙膏粉"", 《口腔护理用品工业》 * |
| 赵丹丹: "《药用植物牡丹皮挥发油的研究》", 30 June 2018, 黑龙江大学出版社 * |
| 鄢海燕等: "《药剂学 第2版》", 31 January 2018, 江苏凤凰科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110478304A (en) * | 2019-08-20 | 2019-11-22 | 广州市金熊大健康科技有限公司 | A kind of toothpaste containing bear gall microcapsules |
| CN110974719A (en) * | 2019-12-26 | 2020-04-10 | 东莞波顿香料有限公司 | Vitamin E sustained-release granules, preparation method thereof and washing and caring product |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2394554C2 (en) | Composition for oral cavity care containing non-aggregated nano-particles of zinc | |
| AU743154B2 (en) | A pharmaceutical composition having two coating layers | |
| KR100814253B1 (en) | Phase transitive breath care products | |
| RU2406522C2 (en) | Method of reducing inflammation of oral cavity tissue with application of magnolia extract | |
| KR100805635B1 (en) | Phase transitive breath care products with increased stability | |
| ES2511047T3 (en) | Pharmaceutical compositions comprising 2-oxo-1-pyrrolidine derivatives | |
| CN101010091A (en) | Oral care composition comprising essential oils | |
| FR2471186A1 (en) | NEW COLIC DELITESCENCE TABLETS AND THEIR PREPARATION PROCESS | |
| HU218971B (en) | Two-component dentifrice for the treatment of dentinal hypersensitivity and method for reducing dentin sensitivity | |
| US20070098650A1 (en) | Dental formulation | |
| EP0725627A1 (en) | Orally-administered dosage form for animals, preparation method therefor and uses thereof | |
| CN109758372A (en) | A kind of pellet and preparation method thereof with preparing the application in oral care product | |
| US20090053309A1 (en) | Adhesive compositions for the treatment of xerostomia | |
| CN103189037B (en) | Oral cavity composition containing micro-aggregation | |
| KR101272738B1 (en) | Method for the preparation of oral capsule and the oral composition containing the capsule powder prepared by the same | |
| WO2004054619A1 (en) | Light-blocking agent and film-forming composition | |
| CN107029208A (en) | It is a kind of to treat lisinopril compound preparation of angiocardiopathy and preparation method thereof | |
| CN108299372B (en) | Medicine for preventing and treating gingivitis and preparation method thereof | |
| JPH1067625A (en) | Composition for oral cavity | |
| JP6315741B2 (en) | Composition for oral cavity containing NSAIDs or heparins | |
| JP2018111668A (en) | Oral formulation | |
| KR102569589B1 (en) | Oral sealing wrap having extendable property | |
| WO2006110183A2 (en) | Dental formulation | |
| KR20200024204A (en) | Oral sealing wrap having extendable property | |
| KR101594592B1 (en) | Tooth whitening compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190517 |
|
| RJ01 | Rejection of invention patent application after publication |