CN109744987A - A kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating method - Google Patents
A kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating method Download PDFInfo
- Publication number
- CN109744987A CN109744987A CN201910100115.0A CN201910100115A CN109744987A CN 109744987 A CN109744987 A CN 109744987A CN 201910100115 A CN201910100115 A CN 201910100115A CN 109744987 A CN109744987 A CN 109744987A
- Authority
- CN
- China
- Prior art keywords
- white light
- light
- camera
- exposure
- exciting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Endoscopes (AREA)
Abstract
The invention discloses a kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating methods, on the basis of double camera beam splitting system, adjusting parameter needed for calculating excitation module according to camera exposure feedback, carry out the Parameter Modulation of exciting light, realize excitation module self-regulating function, to avoid tissue from being irradiated by the long-time of high power density laser, mitigate injury of the exciting light to biological tissue, reduction is burnt a possibility that safe with other photo-biologicals；The excitation light power density for being irradiated to imageable target is kept constant simultaneously, guarantees the stability in fluorescence signal source.
Description
Technical field
The present invention relates to optical imaging field more particularly to a kind of exposure feedback-type fluorescence navigation endoscopic system and
Exciting light self-regulating method.
Background technique
Fluorescence endoscope airmanship is more widely deployed for clinic, becomes research hotspot.Currently, being peeped in fluorescence navigation
Mirror product mainly passes through one camera timesharing imaging and double camera spectroscopic imaging is realized；One camera timesharing imaging by control white light and
Successively stroboscopic, illumination observation region are synthesized by algorithm and are exported to successively obtain white light figure and fluorogram exciting light before and after frames
White light figure with fluorescent marker, but there are distinct disadvantages for this scheme, such as: white light and fluorescence are staggered the time imaging, there are the time difference,
Lead to smear；Imaging frame rate is low, not smooth enough, etc..And double camera beam splitting system is separately photosensitive by white light and fluorescence, passes through algorithm
Synthesis solves one camera timesharing and existing defect is imaged, still, in order to realize higher fluorescence launching efficiency and obtain more preferably
Imaging effect, endoscopic system generally will use laser as fluorescence excitation light source, and integrally be imaged for guarantee system
The excitation light power of effect, the outgoing of endoscope leading portion is usually bigger；And the output of most of fluorescence endoscopy system settings swashs
Optical power is fixed value, when needing close to structure observation details, since lighting area becomes smaller, so that unit area received
Optical power (i.e. radiant illumination) will increase, and will cause and burns or other photo-biological safety problems；In addition, endoscope is in different operating
Under distance, the light area for being irradiated to destination organization is different, excites the excitation optical density of contrast agent also to change, fluorescence is caused to be believed
Number source strength changes therewith, may influence the stability of signal detection terminal fluorescence signal.
Therefore, the existing technology needs to be improved and developed.
Summary of the invention
The purpose of the present invention is to provide a kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulated perfect squares
Method, it is intended to which the output laser power for solving existing double camera spectroscopic imaging fluorescence navigation endoscopic system is fixed value, close
It is easy to cause and burns or other photo-biological security threats and fluorescence signal unstable problem when structure observation.
Technical scheme is as follows:
A kind of exposure feedback-type fluorescence navigates endoscopic system, wherein including light source, light guide bundles, and endoscope, filter plate,
Lens, dichroic beamsplitter, white light camera, fluorescence camera, white light camera control module, exciting light adjustment module；The white light
Camera control module is connect with white light camera, and white light camera control module is connect with exciting light adjustment module, and exciting light adjusts mould
Block is connect with light source；
The light source issues exciting light and white light, exciting light and white light are transmitted by light guide bundles and be coupled in endoscope；
White light and exciting light are emitted from endoscope distal end and reach observed tissue, by the exciting light, the visible light that are observed Tissue reflectance
It is collected with fluorescence by endoscope；Exciting light is filtered out by filter plate, and fluorescence and visible light-transmissive filter plate are by lens focus；It can be seen that
Light penetrates dichroic beamsplitter, images in white light camera；Fluorescence is reflected by dichroic beamsplitter, is detected by fluorescence camera；It is white
Light camera control module calculates the exposure parameter of white light camera according to the image of white light camera, and generates control instruction, will instruct
It is transferred to white light camera and controls its exposure, the exposure parameter of white light camera is transferred to exciting light simultaneously by white light camera control module
Adjustment module；Exciting light adjustment module receives the exposure parameter of white light camera, according to the exposure parameter and exciting light of white light camera
The relationship of power converts, and obtains the adjustment setting parameter of light source, generates control instruction, be modulated to light source.
The exposure feedback-type fluorescence navigation endoscopic system, wherein the exposure parameter of the white light camera includes fast
Door and gain.
A kind of exciting light self-regulating method of exposure feedback-type fluorescence navigation endoscopic system as described in any one of the above embodiments,
Wherein, specifically includes the following steps:
Step S1: the light source issues exciting light and white light, and exciting light and white light are transmitted by light guide bundles and be coupled to interior
In sight glass；
Step S2: white light and exciting light are emitted from endoscope distal end and reach observed tissue, by being observed Tissue reflectance
Exciting light, visible light and fluorescence collected by endoscope；
Step S3: exciting light is filtered out by filter plate, and fluorescence and visible light-transmissive filter plate are by lens focus；
Step S4: visible light-transmissive dichroic beamsplitter images in white light camera；Fluorescence is reflected by dichroic beamsplitter,
Image in fluorescence camera；
Step S5: white light camera control module calculates the exposure parameter of white light camera according to the image of white light camera, and raw
At control instruction, transmits instructions to white light camera and control its exposure, white light camera control module is simultaneously by the exposure of white light camera
Optical parameter is transferred to exciting light adjustment module；
Step S6: exciting light adjustment module receives the exposure parameter of white light camera, according to the exposure parameter of white light camera
It converts with the relationship of excitation light power, obtains the adjustment setting parameter of light source, generate control instruction, light source is adjusted
System.
The exciting light self-regulating method of the exposure feedback-type fluorescence navigation endoscopic system, wherein the step S5-
Detailed process is as follows by step S6: setting the distance between endoscope distal end and observed tissue be D, by it is different be imaged away from
In the case of D, the calculated corresponding exposure parameter of white light camera control module is read, to obtain the exposure parameter of white light camera
With the relationship of distance D；If laser emission illumination required for system fluorescence imaging is E0, at different distance D, actual measurement radiation is shone
Degree is E, by adjusting the Output optical power P of the laser of endoscope distal end outgoing, so that measured value E is equal to E0, interior peep can be obtained
The relationship of the Output optical power P and distance D of the laser of mirror front end outgoing；Finally obtain the exposure parameter and endoscope of white light camera
The relationship of the Output optical power P of the laser of front end outgoing.
The exciting light self-regulating method of the exposure feedback-type fluorescence navigation endoscopic system, wherein the white light phase
The exposure parameter of machine includes shutter and gain.
The exciting light self-regulating method of the exposure feedback-type fluorescence navigation endoscopic system, wherein the white light phase
Step-wise fashion, i.e. lookup table mode can be used in the relationship of the excitation light power of exposure parameter and the endoscope distal end outgoing of machine, obtains
The exposure parameter of white light camera obtains the excitation light power of corresponding endoscope distal end outgoing by tabling look-up.
The exciting light self-regulating method of the exposure feedback-type fluorescence navigation endoscopic system, wherein can fit white
The relation curve of the excitation light power of exposure parameter and the endoscope distal end outgoing of light camera obtains the exposure ginseng of white light camera
Number, by the excitation light power for finding corresponding endoscope distal end outgoing on relation curve.
The exciting light self-regulating method of the exposure feedback-type fluorescence navigation endoscopic system, wherein counted by theory
The relation formula for calculating the exposure parameter of white light camera and the excitation light power of endoscope distal end outgoing, obtains the exposure of white light camera
Optical parameter calculates the excitation light power of corresponding endoscope distal end outgoing by relation formula
Beneficial effects of the present invention: the present invention is navigated endoscopic system and excitation by providing a kind of exposure feedback-type fluorescence
Light self-regulating method, on the basis of double camera beam splitting system, needed for calculating excitation module according to camera exposure feedback
Adjusting parameter carries out the Parameter Modulation of exciting light, excitation module self-regulating function is realized, to avoid tissue by high-power
The long-time of density laser is irradiated, and injury of the exciting light to biological tissue is mitigated, reduce burn with other photo-biologicals safety can
It can property；The excitation light power density for being irradiated to imageable target is kept constant simultaneously, guarantees the stability in fluorescence signal source.
Detailed description of the invention
Fig. 1 is the structural schematic diagram that feedback-type fluorescence navigation endoscopic system is exposed in the present invention.
Fig. 2 is the step process that the exciting light self-regulating method of feedback-type fluorescence navigation endoscopic system is exposed in the present invention
Figure.
Specific embodiment
Embodiments of the present invention are described below in detail, the example of the embodiment is shown in the accompanying drawings, wherein from beginning
Same or similar element or element with the same or similar functions are indicated to same or similar label eventually.Below by ginseng
The embodiment for examining attached drawing description is exemplary, and for explaining only the invention, and is not considered as limiting the invention.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of
The description present invention and simplified description, rather than the device or element of indication or suggestion meaning must have a particular orientation, with spy
Fixed orientation construction and operation, therefore be not considered as limiting the invention.In addition, term " first ", " second " are only used for
Purpose is described, relative importance is not understood to indicate or imply or implicitly indicates the quantity of indicated technical characteristic.
" first " is defined as a result, the feature of " second " can explicitly or implicitly include one or more feature.?
In description of the invention, the meaning of " plurality " is two or more, unless otherwise specifically defined.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected or can mutually communicate；It can be directly connected, it can also be by between intermediary
It connects connected, can be the connection inside two elements or the interaction relationship of two elements.For the ordinary skill of this field
For personnel, the specific meanings of the above terms in the present invention can be understood according to specific conditions.
In the present invention unless specifically defined or limited otherwise, fisrt feature second feature "upper" or "lower"
It may include that the first and second features directly contact, also may include that the first and second features are not direct contacts but pass through it
Between other characterisation contact.Moreover, fisrt feature includes the first spy above the second feature " above ", " above " and " above "
Sign is right above second feature and oblique upper, or is merely representative of first feature horizontal height higher than second feature.Fisrt feature exists
Second feature " under ", " lower section " and " following " include that fisrt feature is directly below and diagonally below the second feature, or is merely representative of
First feature horizontal height is less than second feature.
Following disclosure provides many different embodiments or example is used to realize different structure of the invention.In order to
Simplify disclosure of the invention, hereinafter the component of specific examples and setting are described.Certainly, they are merely examples, and
And it is not intended to limit the present invention.In addition, the present invention can in different examples repeat reference numerals and/or reference letter,
This repetition is for purposes of simplicity and clarity, itself not indicate between discussed various embodiments and/or setting
Relationship.In addition, the present invention provides various specific techniques and material example, but those of ordinary skill in the art can be with
Recognize the application of other techniques and/or the use of other materials.
The endoscopic system as shown in Figure 1, a kind of exposure feedback-type fluorescence navigates, including light source 1, light guide bundles 2, endoscope 3,
Filter plate 4, lens 5, dichroic beamsplitter 6, white light camera 7, fluorescence camera 8, white light camera control module 9, exciting light are adjusted
Module 10；The white light camera control module 9 is connect with white light camera 7, white light camera control module 9 and exciting light adjustment module
10 connections, exciting light adjustment module 10 are connect with light source 1；
The light source 1 issues exciting light and white light, and exciting light and white light transmit by light guide bundles 2 and are coupled to endoscope 3
In；White light and exciting light are emitted from 3 front end of endoscope and reach observed tissue, by be observed Tissue reflectance exciting light, can
Light-exposed and fluorescence is collected by endoscope 3；Exciting light is filtered out by filter plate 4, and fluorescence and visible light-transmissive filter plate 4 are by camera lens 5
It focuses；Visible light-transmissive dichroic beamsplitter 6 images in white light camera 7；Fluorescence is reflected by dichroic beamsplitter 6, by fluorescence phase
Machine 8 is detected；White light camera control module 9 calculates the exposure parameter of white light camera 7 according to the image of white light camera 7, and generates
Control instruction transmits instructions to white light camera 7 and controls its exposure, and white light camera control module 9 is simultaneously by the exposure of white light camera 7
Optical parameter is transferred to exciting light adjustment module 10；Exciting light adjustment module 10 receives the exposure parameter of white light camera 7, according to white light
The exposure parameter of camera 7 and the relationship of excitation light power convert, and parameter is arranged in the adjustment for obtaining light source 1, generate control and refer to
It enables, light source 1 is modulated.
As shown in Fig. 2, a kind of exciting light self-adjusting of exposure feedback-type fluorescence navigation endoscopic system as described above
Method, specifically includes the following steps:
Step S1: light source 1 issues exciting light and white light, and exciting light and white light are transmitted by light guide bundles 2 and be coupled to interior peep
In mirror 3；
Step S2: white light and exciting light are emitted from 3 front end of endoscope and reach observed tissue, by being observed Tissue reflectance
Exciting light, visible light and fluorescence collected by endoscope 3；
Step S3: exciting light is filtered out by filter plate 4, and fluorescence and visible light-transmissive filter plate 4 are focused by camera lens 5；
Step S4: visible light-transmissive dichroic beamsplitter 6 images in white light camera 7；Fluorescence is anti-by dichroic beamsplitter 6
It penetrates, images in fluorescence camera 8；
Step S5: white light camera control module 9 calculates the exposure parameter of white light camera 7 according to the image of white light camera 7, and
Control instruction is generated, white light camera 7 is transmitted instructions to and controls its exposure, white light camera control module 9 is simultaneously by white light camera 7
Exposure parameter be transferred to exciting light adjustment module 10；
Step S6: exciting light adjustment module 10 receives the exposure parameter of white light camera 7, according to the exposure of white light camera 7
Parameter and the relationship of excitation light power convert, obtain light source 1 adjustment be arranged parameter, generate control instruction, to light source 1 into
Row modulation.
Specifically, detailed process is as follows by the step S5- step S6: between 3 front end of endoscope and observed tissue
Distance is different, and lighting area will be different, so that the optical power of unit area also can accordingly change, causes to image in white light camera
7 brightness of image is different, so, white light camera control module 9 can generate different exposure parameters；Therefore, by difference
In the case of image-forming range D (distance D is the distance between 3 front end of endoscope and observed tissue), reads white light camera and control mould
The calculated corresponding exposure parameter of block 9, to obtain the pass of exposure parameter (shutter S and the gain G) and distance D of white light camera 7
System；If laser emission illumination required for system fluorescence imaging (i.e. unit area receive optical power) is E0, difference away from
From under D, radiant illumination E is surveyed, by adjusting the Output optical power P of the laser of 3 front end of endoscope outgoing, so that measured value E etc.
In E0, the relationship of the Output optical power P and distance D of the laser of 3 front end of endoscope outgoing can be obtained；Finally obtain white light camera 7
Exposure parameter and 3 front end of endoscope outgoing laser Output optical power P relationship.
Be further described below: 3 front end of endoscope is different from the distance between observed tissue, and lighting area will not
Together, so that the optical power of unit area also can accordingly change, cause the brightness of image for imaging in white light camera 7 different, so,
White light camera control module 9 can generate different exposure parameters；Therefore, by reading different distance D, (distance D is before endoscope 3
The distance between end and observed tissue) in the case of, white light camera control module 9 calculates corresponding exposure parameter, thus
To the relationship of exposure parameter (shutter S and the gain G) and distance D of white light camera 7, such as the following table 1.
The exposure parameter of 1 white light camera 7 of table and the relationship of distance D
Exciting light radiant illumination required for system fluorescence imaging is set as E0, at different distance D, survey radiant illumination
E, by adjusting the excitation light power P of 3 front end of endoscope outgoing, so that measured value E is equal to E0, so that it may obtain 3 front end of endoscope
The relationship of the excitation light power P and distance D of outgoing, such as the following table 2.
The excitation light power of 2 endoscope of table, 3 front end outgoing and the relationship of distance D
In conjunction with Tables 1 and 2, the exposure parameter of white light camera 7 and the excitation light power of 3 front end of endoscope outgoing can be obtained
Relationship between P, such as the following table 3.
Relationship between the exposure parameter of 3 white light camera 7 of table and the excitation light power of 3 front end of endoscope outgoing
In this way, being converted by the exposure parameter for reading white light camera 7, swashing for 3 front end of endoscope outgoing can be obtained
Luminous power.The exciting light adjustment module 10 can be according to the exposure parameter and table 3 of white light camera 7, to bringing out before endoscope 3
The excitation light power penetrated is adjusted, so that the excitation light irradiance for being irradiated to object plane keeps relatively uniform.
Specifically, the relationship of the exposure parameter of the white light camera 7 and the excitation light power of 3 front end of endoscope outgoing can be with
Using step-wise fashion as shown in table 3, i.e. lookup table mode, obtain the exposure parameter of white light camera 7, by table look-up obtain it is corresponding
The excitation light power of 3 front end of endoscope outgoing；It is also possible to fit the exposure parameter and endoscope 3 of white light camera 7 according to table 3
The relation curve of the excitation light power of front end outgoing, obtains the exposure parameter of white light camera 7, by finding on relation curve pair
The excitation light power for 3 front end of the endoscope outgoing answered；The exposure parameter of white light camera 7 can also be gone out by theoretical calculation and interior peeped
The relation formula of the excitation light power of 3 front end of mirror outgoing, the exposure parameter for obtaining white light camera 7 are calculated by relation formula
The excitation light power of corresponding 3 front end of endoscope outgoing.
The technical program calculates excitation module institute on the basis of double camera beam splitting system, according to camera exposure feedback
The adjusting parameter needed carries out the Parameter Modulation of exciting light, excitation module self-regulating function is realized, to avoid tissue by big
The long-time of power density laser is irradiated, and injury of the exciting light to biological tissue is mitigated, and reduction is burnt and other photo-biologicals safety
A possibility that；The excitation light power density for being irradiated to imageable target is kept constant simultaneously, guarantees the stability in fluorescence signal source.
In the description of this specification, reference term " embodiment ", " certain embodiments ", " schematically implementation
What the description of mode ", " example ", " specific example " or " some examples " etc. meant to describe in conjunction with the embodiment or example
Particular features, structures, materials, or characteristics are contained at least one embodiment or example of the invention.In this specification
In, schematic expression of the above terms are not necessarily referring to identical embodiment or example.Moreover, the specific spy of description
Sign, structure, material or feature can be combined in any suitable manner in any one or more embodiments or example.
It should be understood that the application of the present invention is not limited to the above for those of ordinary skills can
With improvement or transformation based on the above description, all these modifications and variations all should belong to the guarantor of appended claims of the present invention
Protect range.
Claims (8)
- The endoscopic system 1. a kind of exposure feedback-type fluorescence navigates, which is characterized in that including light source, light guide bundles, endoscope, filtering Piece, lens, dichroic beamsplitter, white light camera, fluorescence camera, white light camera control module, exciting light adjustment module；It is described white Light camera control module is connect with white light camera, and white light camera control module is connect with exciting light adjustment module, and exciting light is adjusted Module is connect with light source；The light source issues exciting light and white light, exciting light and white light are transmitted by light guide bundles and be coupled in endoscope；White light Observed tissue is emitted and reached from endoscope distal end with exciting light, by being observed the exciting light of Tissue reflectance, visible light and glimmering Light is collected by endoscope；Exciting light is filtered out by filter plate, and fluorescence and visible light-transmissive filter plate are by lens focus；Visible light is saturating Dichroic beamsplitter is crossed, white light camera is imaged in；Fluorescence is reflected by dichroic beamsplitter, is detected by fluorescence camera；White light phase Machine control module calculates the exposure parameter of white light camera according to the image of white light camera, and generates control instruction, and instruction is transmitted Its exposure is controlled to white light camera, the exposure parameter of white light camera is transferred to exciting light simultaneously and adjusted by white light camera control module Module；Exciting light adjustment module receives the exposure parameter of white light camera, according to the exposure parameter and excitation light power of white light camera Relationship convert, obtain light source adjustment setting parameter, generate control instruction, light source is modulated.
- The endoscopic system 2. exposure feedback-type fluorescence according to claim 1 navigates, which is characterized in that the white light camera Exposure parameter include shutter and gain.
- 3. a kind of exciting light self-regulated of the described in any item exposure feedback-type fluorescence navigation endoscopic systems of such as claims 1 or 2 Adjusting method, which is characterized in that specifically includes the following steps:Step S1: the light source issues exciting light and white light, exciting light and white light are transmitted by light guide bundles and be coupled to endoscope In；Step S2: white light and exciting light are emitted from endoscope distal end and reach observed tissue, by being observed swashing for Tissue reflectance It shines, visible light and fluorescence are collected by endoscope；Step S3: exciting light is filtered out by filter plate, and fluorescence and visible light-transmissive filter plate are by lens focus；Step S4: visible light-transmissive dichroic beamsplitter images in white light camera；Fluorescence is reflected by dichroic beamsplitter, imaging In fluorescence camera；Step S5: white light camera control module calculates the exposure parameter of white light camera according to the image of white light camera, and generates control System instruction transmits instructions to white light camera and controls its exposure, and white light camera control module simultaneously joins the exposure of white light camera Number is transferred to exciting light adjustment module；Step S6: exciting light adjustment module receives the exposure parameter of white light camera, according to the exposure parameter of white light camera and swashs The relationship of luminous power converts, and obtains the adjustment setting parameter of light source, generates control instruction, be modulated to light source.
- 4. the exciting light self-regulating method of exposure feedback-type fluorescence navigation endoscopic system according to claim 3, special Sign is that detailed process is as follows by the step S5- step S6: setting the distance between endoscope distal end and observed tissue are D, by the calculated corresponding exposure parameter of white light camera control module being read, to obtain in different image-forming range D The exposure parameter of white light camera and the relationship of distance D；If laser emission illumination required for system fluorescence imaging is E0, in difference Under distance D, actual measurement radiant illumination is E, by adjusting the Output optical power P of the laser of endoscope distal end outgoing, so that measured value E Equal to E0, the relationship of the Output optical power P and distance D of the laser of endoscope distal end outgoing can be obtained；Finally obtain white light camera Exposure parameter and endoscope distal end outgoing laser Output optical power P relationship.
- 5. the exciting light self-regulating method of exposure feedback-type fluorescence navigation endoscopic system according to claim 4, special Sign is that the exposure parameter of the white light camera includes shutter and gain.
- 6. according to the exciting light self-adjusting of the described in any item exposure feedback-type fluorescence navigation endoscopic systems of claim 4 or 5 Method, which is characterized in that the relationship of the excitation light power of exposure parameter and the endoscope distal end outgoing of the white light camera can adopt With step-wise fashion, i.e. lookup table mode, the exposure parameter of white light camera is obtained, obtains corresponding endoscope distal end outgoing by tabling look-up Excitation light power.
- 7. according to the exciting light self-adjusting of the described in any item exposure feedback-type fluorescence navigation endoscopic systems of claim 4 or 5 Method, which is characterized in that the relationship of the exposure parameter of white light camera and the excitation light power of endoscope distal end outgoing can be fitted Curve obtains the exposure parameter of white light camera, by the exciting light for finding corresponding endoscope distal end outgoing on relation curve Power.
- 8. according to the exciting light self-adjusting of the described in any item exposure feedback-type fluorescence navigation endoscopic systems of claim 4 or 5 Method, which is characterized in that go out the exposure parameter of white light camera and the excitation light power of endoscope distal end outgoing by theoretical calculation Relation formula, obtain the exposure parameter of white light camera, by relation formula, calculate swashing for corresponding endoscope distal end outgoing Luminous power.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910100115.0A CN109744987A (en) | 2019-01-31 | 2019-01-31 | A kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910100115.0A CN109744987A (en) | 2019-01-31 | 2019-01-31 | A kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109744987A true CN109744987A (en) | 2019-05-14 |
Family
ID=66407128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910100115.0A Pending CN109744987A (en) | 2019-01-31 | 2019-01-31 | A kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109744987A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112642064A (en) * | 2020-12-22 | 2021-04-13 | 沈阳雷卓激光医疗器械有限公司 | Laser gap emission method and device |
| CN113376099A (en) * | 2021-06-29 | 2021-09-10 | 安图实验仪器(郑州)有限公司 | QPCR (quench-Polish-quench) excitation light intensity automatic adjustment method and QPCR excitation light intensity automatic adjustment system based on standard |
| CN114052908A (en) * | 2021-12-01 | 2022-02-18 | 辽宁北镜医疗科技有限公司 | Navigation system and method in near-infrared fluorescence operation based on illumination adjustment |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478174A (en) * | 2018-03-20 | 2018-09-04 | 广东欧谱曼迪科技有限公司 | Fluorescence navigation method of adjustment in dual camera systems and its art based on exposure feedback |
| CN108523819A (en) * | 2018-03-20 | 2018-09-14 | 广东欧谱曼迪科技有限公司 | Survey the fluorescence navigation endoscopic system and laser power automatic adjusting method of light feedback |
| CN210749128U (en) * | 2019-01-31 | 2020-06-16 | 广东欧谱曼迪科技有限公司 | Exposure feedback type fluorescence navigation endoscope system based on excitation light self-adjustment |
-
2019
- 2019-01-31 CN CN201910100115.0A patent/CN109744987A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478174A (en) * | 2018-03-20 | 2018-09-04 | 广东欧谱曼迪科技有限公司 | Fluorescence navigation method of adjustment in dual camera systems and its art based on exposure feedback |
| CN108523819A (en) * | 2018-03-20 | 2018-09-14 | 广东欧谱曼迪科技有限公司 | Survey the fluorescence navigation endoscopic system and laser power automatic adjusting method of light feedback |
| CN210749128U (en) * | 2019-01-31 | 2020-06-16 | 广东欧谱曼迪科技有限公司 | Exposure feedback type fluorescence navigation endoscope system based on excitation light self-adjustment |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112642064A (en) * | 2020-12-22 | 2021-04-13 | 沈阳雷卓激光医疗器械有限公司 | Laser gap emission method and device |
| CN113376099A (en) * | 2021-06-29 | 2021-09-10 | 安图实验仪器(郑州)有限公司 | QPCR (quench-Polish-quench) excitation light intensity automatic adjustment method and QPCR excitation light intensity automatic adjustment system based on standard |
| CN114052908A (en) * | 2021-12-01 | 2022-02-18 | 辽宁北镜医疗科技有限公司 | Navigation system and method in near-infrared fluorescence operation based on illumination adjustment |
| CN114052908B (en) * | 2021-12-01 | 2024-02-13 | 辽宁北镜医疗科技有限公司 | Near infrared fluorescence intraoperative navigation system and method based on illumination adjustment |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108478174B (en) | Double camera system based on exposure feedback and intraoperative fluorescence navigation adjustment method thereof | |
| CN109744987A (en) | A kind of exposure feedback-type fluorescence navigation endoscopic system and exciting light self-regulating method | |
| JP4846042B2 (en) | Ophthalmic imaging apparatus, ophthalmic system, and program | |
| CN105534470B (en) | A kind of confocal microscopy endoscopic system and its adjusting method | |
| US11076106B2 (en) | Observation system and light source control apparatus | |
| CN108523819A (en) | Survey the fluorescence navigation endoscopic system and laser power automatic adjusting method of light feedback | |
| CN108670172A (en) | Based on fluorescence navigation method of adjustment in the fluorescence navigation system and its art for surveying light feedback | |
| EP3556309B1 (en) | System for fluorescence-based laser ablation | |
| CN101923210B (en) | Light source assembly for an illumination device of a medical optical observation device | |
| US11719920B2 (en) | Observation assisting device, information processing method, and program | |
| CN109758094A (en) | A kind of focusing feedback-type fluorescence navigation endoscopic system and image are from processing method | |
| CN210749128U (en) | Exposure feedback type fluorescence navigation endoscope system based on excitation light self-adjustment | |
| US9055862B2 (en) | Image processing device and image processing method | |
| CN108814525A (en) | The fluorescence navigation endoscopic system and laser power automatic adjusting method of focusing feedback | |
| JPWO2018003263A1 (en) | Observation apparatus and control method of observation apparatus | |
| CN109744986A (en) | A kind of exposure feedback-type fluorescence navigation endoscopic system and image procossing self-regulating method | |
| CN109744984A (en) | A kind of focusing feedback-type fluorescence navigation endoscopic system and detectable signal method of adjustment | |
| CN209450493U (en) | A kind of fluorescence navigation endoscopic system based on focusing feedback | |
| CN109744985A (en) | A kind of exposure feedback-type fluorescence navigation endoscopic system and detectable signal method of adjustment | |
| CN210749129U (en) | Photometric feedback fluorescence endoscope system based on fluorescence image processing | |
| CN109758093A (en) | It is a kind of to instruct exposed type fluorescence endoscopy system and instruct exposure method | |
| CN209122170U (en) | A kind of dual camera systems based on exposure feedback | |
| CN210228086U (en) | Exposure feedback type fluorescence navigation endoscope system based on detection signal adjustment | |
| CN209450511U (en) | A kind of fluorescence navigation system based on survey light feedback | |
| CN109758096A (en) | A kind of survey light feedback fluorescence endoscopy system and fluorescence image processing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |