CN109731092A - A kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome Download PDFInfo
- Publication number
- CN109731092A CN109731092A CN201910150515.2A CN201910150515A CN109731092A CN 109731092 A CN109731092 A CN 109731092A CN 201910150515 A CN201910150515 A CN 201910150515A CN 109731092 A CN109731092 A CN 109731092A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- predominant
- bowel syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to technical field of Chinese medicine, and in particular to a kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome (IBS-C).The composition includes following raw material: radix bupleuri, the dried immature fruit of citron orange, Radix Paeoniae Alba, fructus cannabis, betel nut, the coptis, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, Siraitia grosvenorii and Radix Glycyrrhizae.Above all medicines press specific weight ratio phase 5, liver and spleen and it can control, logical mend parallel, giving consideration to both the incidental and fundamental, the turbid removing toxic substances of playing, logical internal organs let out the benefits of turbid altogether, the symptoms such as constipation, the abdominal pain of IBS-C can be effectively improved, curative effect is clear, and cure rate is high, and recurrence rate is low, and it is cheap, it can reduce the medical expense of IBS-C.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of Chinese traditional medicine composition for treating constipation-predominant of irritable bowel syndrome
Object and preparation method thereof.
Background technique
Irritable bowel syndrome (IBS) belongs to functions of intestines and stomach disorder disease, is one of common disease of gastroenterology, clinical table
It is now abdominal pain, abdominal distension, diarrhea, bowl evacuation habit change and stool exception etc..IBS can be divided into diarrhea-type (IBS-D), constipation
Type (IBS-C), mixed type (IBS-M) and prepattern (IBS-U), wherein IBS-C illness rate rises year by year.The IBS-C course of disease is long, multiple
Hair rate is high, and patient shows as constipation, abdominal pain, abdominal distension etc. and mostly with the whole bodies mental symptom such as anxiety, depression, seriously affects it
It is physically and mentally healthy.Since the IBS-C cause of disease is complicated, pathogenesis is unknown, doctor trained in Western medicine lacks active drug and specific therapy target at present,
Give symptomatic treatment (Cisapride, Otilonium Bromide, Sertraline etc.) more, though can reduce symptom, have medical expense is high, drug according to
The shortcomings that Lai Xinggao, high recurrence rate.
Chinese medicine also has irritable bowel syndrome a large amount of relevant reports, but grinds for the correlation of diarrhea-type irritability syndrome
Study carefully more, the correlative study for constipation-predominant of irritable bowel syndrome is less.Chinese medicine or using diagnosis and treatment carry out experiential therapy or
Treated using compound aloe capsule, curative effect is different, efficient to be improved, and after being discontinued it is easy to recur be still inevitable it is scarce
Point.
Summary of the invention
The technical issues of for the height of IBS-C medical expense in the prior art, high recurrence rate, the present invention provides a kind of treat just
The Chinese medicine composition of secret type irritable bowel syndrome.
And the present invention also provides the preparation methods of the Chinese medicine composition of three kinds for the treatment of constipation-predominant of irritable bowel syndrome.
To achieve the above object of the invention, the embodiment of the present invention uses the following technical solution:
A kind of Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, the raw material including following parts by weight proportion: bavin
8~12 parts recklessly, 8~12 parts of the dried immature fruit of citron orange, 10~15 parts of Radix Paeoniae Alba, 8~12 parts of fructus cannabis, 5~8 parts of betel nut, 5~8 parts of the coptis, hairy euphorbia
8~12 parts, 8~12 parts of fiveleaf akebia fruit, 5~8 parts of chingma abutilon seed, 5~8 parts of rhizoma zingiberis, 10~15 parts of Poria cocos, 8~12 parts of Siraitia grosvenorii and sweet
5~8 parts of grass.
Radix bupleuri acrid flavour, hardship, cold nature return liver, gallbladder, lung channel, and inducing diaphoresis is brought down a fever, soothing liver-qi stagnation, lifting disease；Dried immature fruit of citron orange bitter,
Pungent, slightly sour, slightly warm in nature, returns spleen, stomach meridian, relieving stagnant Qi disperse accumulation, resolving sputum is except ruffian.In the present compositions, radix bupleuri master enters liver and gallbladder warp, and function is arrogated to oneself thin
The stasis of smooth Liver Channel, item reach irritability；Dried immature fruit of citron orange returns spleen, stomach, large intestine channel, are longer than consumer product dredge stasis, and logical internal organs lets out turbid, and radix bupleuri compatibility, and one
A drop is risen, the function of ascending the clear and descending the turbid is played altogether, is combined into monarch drug in a prescription.
Radix Paeoniae Alba bitter, acid, cold nature return liver, the spleen channel, and yin is held back in blood-nourishing, and soft liver is with relieving spasm to stop pain, suppressing liver-YANG.In this group
It closes in object, Radix Paeoniae Alba and monarch drug in a prescription radix bupleuri compatibility, one blood of a gas, liver can be controlled and do not reached with it and soft liver benefiting yin tonifying liver body.
Fructus cannabis is sweet in flavor, mild-natured, returns spleen, stomach, large intestine channel, the depressed constipation of patent large intestine, and internal organs is led in especially kind ease constipation.
It is betel nut bitter, pungent, it is warm-natured, return stomach, large intestine channel, promoting the circulation of qi, Li Shui, desinsection, disperse accumulation, preventing malaria.Since the pungent row of betel nut is bitter
It lets out, specially enters stomach and intestine and pass through, the gas of benefaction stomach and intestine, the removing stagnancy and obstruction of the fu-organs, therefore in the present compositions, betel nut is mutually assisted with fructus cannabis, the dried immature fruit of citron orange, makes to lead to
It is strong that internal organs lets out turbid power benefit.
Coptis bitter, cold in nature, return heart, spleen, stomach, liver, gallbladder, large intestine channel, heat-clearing, eliminating dampness, purging intense heat, removing toxic substances.In this composition
In, coptis bitter cold drop is let out, and is longer than clear dampness-heat in middle jiao, is changed turbid removing toxic substances, is altogether ministerial drug with Radix Paeoniae Alba, fructus cannabis and betel nut.
Hairy euphorbia bitter, acid, cool in nature, return lung, bladder, large intestine channel, heat-clearing, removing toxic substances, dampness removing are antipruritic；Chingma abutilon seed is sweet in flavor,
It is puckery, it is cool in nature, enter intestine and small intestine, bladder meridian, promoting diuresis for stranguria, laxation defaecation.In the present compositions, hairy euphorbia, chingma abutilon seed help the coptis altogether
The turbid removing toxic substances of heat-clearingization.
Fiveleaf akebia fruit is sweet in flavor, cold in nature, returns liver, stomach, bladder meridian, dispersing stagnated hepatoqi, promoting blood circulation, removing blood stasis and acesodyne, relieving restlessness, diuresis, at this
The fluent Liver Channel stasis of principal drug assistance radix bupleuri in composition.
Rhizoma zingiberis acrid flavour, property heat, returns spleen, stomach, kidney, the heart, lung channel, master enter taste warp, are good for fortune spleen sun, warming spleen and stomach for dispelling cold, Hui Yangtong
Arteries and veins, warming lung and resolving fluid.In the present compositions, the hot property of rhizoma zingiberis can help the mistake of the cold medicines such as radix bupleuri processed, Radix Paeoniae Alba, the coptis, fiveleaf akebia fruit
In cold and cool pharmacological property, so that this composition bitter-cold herbs expelling heat, without hindering stomach, hot invigorating the spleen is greasy without growing.
Poria cocos is sweet in flavor, light, mild-natured, return heart, lung, spleen, kidney channel, invigorating spleen, clearing damp and promoting diuresis, changes turbid, calming heart, in this combination
Can make in object it is wet without gathering, it is turbid to have no way of giving birth to, prevent the source of turbid pathogenic factor metaplasia, shared with fructus cannabis, betel nut, the dried immature fruit of citron orange, both clear it is clear
Source, and to heresy with outlet.
Siraitia grosvenorii is sweet in flavor, cool in nature, return lung, large intestine channel, removing heat from the lung and relieving sorethroat, preventing phlegm from forming and stopping coughing, relax bowel and defecation, is apt to clear purging the lung of pathogenic fire heat, from
And lung qi tonneau, facilitate large intestine conduction function.
Radix Glycyrrhizae is sweet in flavor, mild-natured, return heart, lung, spleen, stomach meridian, is apt to invigorate the spleen and benefit qi into middle coke, expelling phlegm and arresting coughing, relieving spasm to stop pain, clearly
Thermal detoxification is harmonious with Poria cocos in the present compositions, the former strengthening spleen and middle warmer, keeps without walking, the latterization is turbid to help fortune, walks without keeping, two
Person complements each other, and invigorating the spleenization is turbid.Radix Glycyrrhizae compatibility Radix Paeoniae Alba simultaneously, can enhance the function of relieving spasm to stop pain.
Hairy euphorbia, chingma abutilon seed, fiveleaf akebia fruit, rhizoma zingiberis, Poria cocos, Siraitia grosvenorii and Radix Glycyrrhizae are adjutant altogether in the present compositions.Wherein,
Radix Glycyrrhizae energy coordinating the drug actions of a prescription, in the present compositions and to make medicine.
Above all medicines press specific weight ratio phase 5, can liver and spleen and control, it is logical mend parallel, giving consideration to both the incidental and fundamental, playing is turbid altogether
Removing toxic substances, logical internal organs let out the benefits of turbid, can be effectively improved the symptoms such as constipation, the abdominal pain of IBS-C, and curative effect is clear, and cure rate is high, recurrence rate
It is low and cheap, it can reduce the medical expense of IBS-C.
Chinese medicine in existing research for IBS is identical as part material in the application: in CN201110178870.4
Radix bupleuri, Radix Paeoniae Alba, the dried immature fruit of citron orange, the coptis and Radix Glycyrrhizae, radix bupleuri, Radix Paeoniae Alba, Poria cocos, the coptis and rhizoma zingiberis in CN201510679942.1,
Hairy euphorbia, the dried immature fruit of citron orange, Radix Glycyrrhizae, betel nut and the coptis in CN201210594484.8, the Poria cocos and eight in CN201510329947.1
Month letter.But the above-mentioned prior art is directed to IBS-D, although the etiology and pathogenesis of IBS-D and IBS-C communicates place, such as feelings will, drink
Food, taste are not transported, liver mistake item reaches etc., but there is some difference for the two, the former is the lower person by incoordination between the liver and the spleen or enteron aisle pure and impure mix
In the majority, the latter's Ze Yin enteron aisle conduction function obstacle causes, and the two primary symptom is different, therefore, Chinese traditional medicine composition effective for IBS-D
Object is not necessarily effective to IBS-C, it could even be possible to playing reaction.The present invention is that therapy carries out the side's of sending use with " ventilation quality "
Medicine has creatively been selected in other each tastes although having selected the Chinese medicine (such as radix bupleuri, the dried immature fruit of citron orange, Radix Paeoniae Alba) for IBS-D
Medicine, and the ratio of each drug in prescription is optimized simultaneously, so that Chinese medicine composition of the invention is made to can be used in treating IBS-C,
It is significant in efficacy and can effectively treat recurrence.Chinese medicine composition of the invention simultaneously can also be used to want disease in IBS-M based on constipation
The patient of shape.
Preferably, the composition includes the raw material of following parts by weight proportion: 8~10 parts of radix bupleuri, 8~10 parts of the dried immature fruit of citron orange, white
11~14 parts of Chinese herbaceous peony, 8~10 parts of fructus cannabis, 5~7 parts of betel nut, 5~7 parts of the coptis, 9~11 parts of hairy euphorbia, 9~11 parts of fiveleaf akebia fruit, winter
5~7 parts of certain herbaceous plants with big flowers, 5~7 parts of rhizoma zingiberis, 11~14 parts of Poria cocos, 9~11 parts of Siraitia grosvenorii and 5~7 parts of Radix Glycyrrhizae.
Preferably, the composition includes the raw material of following parts by weight proportion: 9 parts of radix bupleuri, 9 parts of the dried immature fruit of citron orange, 12 parts of Radix Paeoniae Alba, fire
9 parts of edestan, 6 parts of betel nut, 6 parts of the coptis, 10 parts of hairy euphorbia, 10 parts of akebiae, 6 parts of chingma abutilon seed, 6 parts of rhizoma zingiberis, 12 parts of Poria cocos, arhat
10 parts and 6 parts of Radix Glycyrrhizae of fruit.
And the embodiment of the invention also provides a kind of preparations of Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome
Method, the preparation method is that: by radix bupleuri, the dried immature fruit of citron orange, Radix Paeoniae Alba, fructus cannabis, betel nut, the coptis, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, do
After ginger, Poria cocos, Siraitia grosvenorii and Radix Glycyrrhizae crush respectively, each raw material powder is weighed by the raw material proportioning in above-mentioned composition, is mixed, i.e.,
?.
The preparation method process is simple, easy to implement, both convenient for large-scale production, is also convenient for low dose of preparation.Gained is former
Material mixture of powders can directly be taken, and the oral agents such as tablet, capsule, granule, powder or pill can also further be made
Type.
And the embodiment of the invention also provides the systems of the Chinese medicine composition of second for the treatment of constipation-predominant of irritable bowel syndrome
Preparation Method, the preparation method is that: weigh each raw material by the raw material proportioning in above-mentioned composition, mix, extract to get.
After raw material is extracted, effective component concentration is significantly improved in products obtained therefrom, can be reduced patient's medication dose, be mentioned
High drug compliance.The mouths such as tablet, capsule, granule, powder, pill or oral solution can be further made by extracting products obtained therefrom
Oral dosage form.
Preferably, the operation of extraction is first to be extracted with water, then the ethyl alcohol for being 65~95% with concentration expressed in percentage by volume extracts,
Combined extract.Water is extracted and is used in combination with ethyl alcohol extraction, can fully extract the water solubility in composition as far as possible
Ingredient and Alcohol soluble composition keep the effect of products obtained therefrom treatment IBS-C more preferable.Decoction extraction or ultrasound can be used in the method for extraction
It extracts.
Preferably, the operation of the extraction further includes by the concentration of gained extracting solution, drying.Gained extracting solution is concentrated and dried
The dry product obtained afterwards is easy to carry, transport and uses, and convenient for it is subsequent solid orally ingestible is made when directly feed intake.
And the embodiment of the invention also provides the systems of the Chinese medicine composition of the third treatment constipation-predominant of irritable bowel syndrome
Preparation Method, the preparation method is that: each raw material is weighed by the raw material proportioning in above-mentioned Chinese medicine composition, is extracted respectively, is made and mentions
Take object powder, by the extract powder mix to get.
The mode that raw material is extracted respectively convenient for mass production to the batch extracting of each raw material, further according to extraction when clinical use
The corresponding material quantity of object is mixed.This method can either reduce medication dose, and it is right as needed to be also convenient in clinical use
The usage ratio of each extract is adjusted.
Preferably, the operation of the radix bupleuri is extracted are as follows: decoct the ethyl alcohol that radix bupleuri concentration expressed in percentage by volume is 45~65%
It extracts 2~3 times, 20~30min, merging filtrate, are concentrated, are dry to get bupleurum extract powder every time；Extract the dried immature fruit of citron orange
Operation are as follows: use water boiling and extraction 2~3 times, 20~40min, merging filtrate, are concentrated, are dry to get Bitter Orang P.E powder every time
End.Radix bupleuri is extracted within preferred extraction time using the ethyl alcohol of the concentration range, water is used to exist as Extraction solvent
The dried immature fruit of citron orange is extracted in preferred extraction time, can make to extract and played between resulting bupleurum extract and Bitter Orang P.E
Better compatibility effect, to improve the effect for the treatment of IBS-C.
Preferably, with water to the Radix Paeoniae Alba, fructus cannabis, betel nut, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, arhat
Fruit and Radix Glycyrrhizae are extracted respectively, are extracted with the ethyl alcohol that concentration expressed in percentage by volume is 45~65% to the coptis.With the extraction side
The extract obtained powder of method can preferably play ministerial drug, adjutant and the effect for making medicine, make the extract of each raw material in composition
Between play preferably synergistic effect, further increase treatment IBS-C effect.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
Embodiment 1
The embodiment of the invention provides a kind of Chinese medicine compositions for treating constipation-predominant of irritable bowel syndrome, including following weight
The raw material of number proportion: radix bupleuri 8g, dried immature fruit of citron orange 8g, Radix Paeoniae Alba 10g, fructus cannabis 8g, betel nut 5g, coptis 5g, hairy euphorbia 8g, fiveleaf akebia fruit
8g, chingma abutilon seed 5g, rhizoma zingiberis 5g, Poria cocos 10g, Siraitia grosvenorii 8g and Radix Glycyrrhizae 5g.
Preparation method:
After above-mentioned raw materials are mixed, with water ultrasonic extraction 2 times, each 1h.The gained dregs of a decoction use 95%v/v second again after water is mentioned
Alcohol ultrasonic extraction 2 times, each 0.5h.Gained filtrate will be extracted every time to merge, concentration, it is dry to get.
Embodiment 2
The embodiment of the invention provides a kind of Chinese medicine compositions for treating constipation-predominant of irritable bowel syndrome, including following weight
The raw material of number proportion: radix bupleuri 8g, dried immature fruit of citron orange 8g, Radix Paeoniae Alba 11g, fructus cannabis 8g, betel nut 5g, coptis 5g, hairy euphorbia 9g, fiveleaf akebia fruit
9g, chingma abutilon seed 5g, rhizoma zingiberis 5g, Poria cocos 11g, Siraitia grosvenorii 9g and Radix Glycyrrhizae 5g.
Preparation method:
After above-mentioned raw materials are mixed, with water boiling and extraction 2 times, each 1h.The gained dregs of a decoction use 65%v/v second again after water is mentioned
Alcohol, which decocts, to be extracted 2 times, each 0.5h.Gained filtrate will be extracted every time to merge, concentration, it is dry to get.
Embodiment 3
The embodiment of the invention provides a kind of Chinese medicine compositions for treating constipation-predominant of irritable bowel syndrome, including following weight
The raw material of number proportion: radix bupleuri 9g, dried immature fruit of citron orange 9g, Radix Paeoniae Alba 12g, fructus cannabis 9g, betel nut 6g, coptis 6g, hairy euphorbia 10g, akebiae
10g, chingma abutilon seed 6g, rhizoma zingiberis 6g, Poria cocos 12g, Siraitia grosvenorii 10g and Radix Glycyrrhizae 6g.
Preparation method:
By radix bupleuri, the dried immature fruit of citron orange, Radix Paeoniae Alba, fructus cannabis, betel nut, the coptis, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, arhat
After fruit and Radix Glycyrrhizae are ground into a powder respectively, weigh each raw material powder by above-mentioned raw materials proportion, mixing to get.
Embodiment 4
The embodiment of the invention provides a kind of Chinese medicine compositions for treating constipation-predominant of irritable bowel syndrome, including following weight
The raw material of number proportion: radix bupleuri 100g, dried immature fruit of citron orange 100g, Radix Paeoniae Alba 140g, fructus cannabis 100g, betel nut 70g, coptis 70g, hairy euphorbia
110g, fiveleaf akebia fruit 110g, chingma abutilon seed 70g, rhizoma zingiberis 70g, Poria cocos 140g, Siraitia grosvenorii 110g and Radix Glycyrrhizae 70g.
Preparation method:
The ethyl alcohol that radix bupleuri concentration expressed in percentage by volume is 45% is decocted and is extracted 2 times, each 30min, merging filtrate, concentration,
Drying is to get bupleurum extract powder.
By the dried immature fruit of citron orange with water boiling and extraction 3 times, each 20min, merging filtrate, concentration, drying are to get Bitter Orang P.E powder
End.
Radix Paeoniae Alba, fructus cannabis, betel nut, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, Siraitia grosvenorii and Radix Glycyrrhizae are used respectively
Water is decocted and is extracted 3 times, each 30min, merging filtrate, and concentration, drying are to get corresponding extract powder.
The ethyl alcohol that coptis concentration expressed in percentage by volume is 45% is decocted and is extracted 2 times, each 30min, merging filtrate, concentration,
Drying is to get coptis extract powder.
Will above each extract powder mix to get.
Embodiment 5
The embodiment of the invention provides a kind of Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, raw material includes following
The component of parts by weight proportion: it radix bupleuri 120g, dried immature fruit of citron orange 120g, Radix Paeoniae Alba 150g, fructus cannabis 120g, betel nut 80g, coptis 80g, flies upward
Careless 120g, fiveleaf akebia fruit 120g, chingma abutilon seed 80g, rhizoma zingiberis 80g, Poria cocos 150g, Siraitia grosvenorii 120g and Radix Glycyrrhizae 80g.
Preparation method:
The ethyl alcohol that radix bupleuri concentration expressed in percentage by volume is 65% is decocted and is extracted 3 times, each 20min, merging filtrate, concentration,
Drying is to get bupleurum extract powder.
By the dried immature fruit of citron orange with water boiling and extraction 2 times, each 40min, merging filtrate, concentration, drying are to get Bitter Orang P.E powder
End.
Radix Paeoniae Alba, fructus cannabis, betel nut, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, Siraitia grosvenorii and Radix Glycyrrhizae are used respectively
Water is decocted and is extracted 2 times, each 45min, merging filtrate, and concentration, drying are to get corresponding extract powder.
The ethyl alcohol that coptis concentration expressed in percentage by volume is 65% is decocted and is extracted 3 times, each 20min, merging filtrate, concentration,
Drying is to get coptis extract powder.
Will above each extract powder mix to get.
Comparative example 1
This comparative example provides a kind of Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, including following parts by weight
The raw material of proportion: radix bupleuri 9g, dried orange peel 9g, Radix Paeoniae Alba 12g, fructus cannabis 9g, betel nut 6g, coptis 6g, hairy euphorbia 10g, akebiae 10g,
Chingma abutilon seed 6g, rhizoma zingiberis 6g, Poria cocos 12g, Siraitia grosvenorii 10g and Radix Glycyrrhizae 6g.
Preparation method is the same as embodiment 3.
Comparative example 2
This comparative example provides a kind of Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, including following parts by weight
The raw material of proportion: radix bupleuri 9g, dried immature fruit of citron orange 9g, Radix Paeoniae Alba 12g, fructus cannabis 9g, betel nut 6g, coptis 6g, hairy euphorbia 10g, caulis akebiae 10g, winter
Certain herbaceous plants with big flowers 6g, rhizoma zingiberis 6g, Poria cocos 12g, Siraitia grosvenorii 10g and Radix Glycyrrhizae 6g.
Preparation method is the same as embodiment 3.
Effect example 1
This effect example provides the clinical effectiveness that the Chinese medicine composition of constipation-predominant of irritable bowel syndrome is treated in the present invention:
1, subjects
Choose in January, 2018~2019 year outpatient service in January IBS-C patient, according to random, voluntary principle be divided into test group,
1 group of comparative example, 2 groups of comparative example, control group, each group Gender, age, the course of disease, state of an illness aspect have comparable without significant difference
Property.As shown in table 1.
1 each group subjects situation of table
2, test method
All patients give diet modification and psychological counseling.
Test group is treated with 3 products obtained therefrom of the embodiment of the present invention, and one time a day, each 10g, warm water takes after meal.
2 groups of 1 group of comparative example and comparative example are treated with comparative example 1 of the present invention, 2 products obtained therefrom of comparative example respectively, and daily 1
Secondary, each 10g, warm water takes after meal.
Control group is treated with Trimebutine piece, and 3 times a day, 2 tablets once, oral meal.
Adverse reaction rate during the clinical effectiveness of each group patient and medication after comparing 2 weeks.Follow-up 1 year after 2 weeks,
Observe recurrence.
3, test result
Clinical evaluation is carried out by following standard:
Effective: every 1~2d defecation 1 time, smooth forming of defecating, clinical symptoms disappear；
It is effective: defecation 1 time in 2d, although stool it is soft, even to have the unsmooth sense of defecation, clinical symptoms mitigate earlier above；
Invalid: nothing is clearly better before clinical symptoms are relatively taken medicine, or even aggravates.
Obvious effective rate=effective number of cases/total number of cases × 100%；
Total effective rate=(effective number of cases+effective number of cases)/total number of cases × 100%；
Recurrence rate=recurrence number of cases/total number of cases × 100%.
The results are shown in Table 2.
2 each group test result of table
By 2 result of table as it can be seen that test group, 1 group of comparative example and 2 groups of comparative example of obvious effective rate, total effective rate, recurrence rate and
Adverse reaction situation is significantly better than control group, and the obvious effective rate of test group, total effective rate and recurrence rate are significantly better than comparison
1 group of example and 2 groups of comparative example.The result illustrates that composition provided by the invention can effectively treat IBS-C, and effectively treatment is multiple
Hair, and have no adverse reaction.
Effect example 2
This effect example provides the typical case that the Chinese medicine composition of constipation-predominant of irritable bowel syndrome is treated in the present invention:
Zhang, female, 48 years old, people from Shijiazhuang City of Hebei Province, company clerk.Patient is usually introverted, dry and hard excrement, abdomen
Bitterly, it feels depressed more than 1 year, looks into electronic colonoscope in certain provincial Grade A hospital and show Non Apparent Abnormality, it is easy to be diagnosed as constipation type intestines
Bowel syndrome, interruption are taken west spring mouth reservoir symptom and are alleviated, but Relapse rate after being discontinued.It gives and is made by inventive embodiments 3
After 14 doses of the Chinese medicine composition (every dose of 10g) of the middle treatment constipation-predominant of irritable bowel syndrome obtained, constipation situation improves earlier above,
Abdominal pain mitigates, and keeps this formula and continues further consultation after raising 2 months, and day a line of defecating is emotionally stable, remaining no discomfort.Follow-up 1 year, without multiple
Hair.
It is huge certain, female, 61 years old, Quyang County Pang man, Hebei province people from low-lying area.In July, 2011, emotional lability due to anger, gradually appeared
It defecates stiff, abdominal distension is diagnosed as constipation-predominant of irritable bowel syndrome in local hospital, delays refractory.Take the system of the embodiment of the present invention 4
Middle treatment constipation-predominant of irritable bowel syndrome 30 doses of Chinese medicine composition (every dose of 1.5g) after, greatly can a line on the one, just matter
Normally, it is emotionally stable.It follow-up June, does not recur again.
Sun, female, 20 years old, Shijiazhuang City of Hebei Province people from the town Tong Ye.2016 because board at school defecate it is irregular, in addition preparing for war height
It examines nervous, gradually appears constipation, abdominal pain, acne.It is comprehensive to take middle treatment constipation type intestines easily swash made from the embodiment of the present invention 2
30 doses of the Chinese medicine composition (every dose of 1.5g) of simulator sickness gives psychological intervention simultaneously afterwards, fully recovers, follow-up 2 years, does not recur again after January.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, which is characterized in that matched including following parts by weight
Raw material: 8~12 parts of radix bupleuri, 8~12 parts of the dried immature fruit of citron orange, 10~15 parts of Radix Paeoniae Alba, 8~12 parts of fructus cannabis, 5~8 parts of betel nut, the coptis 5~8
Part, 8~12 parts of hairy euphorbia, 8~12 parts of fiveleaf akebia fruit, 5~8 parts of chingma abutilon seed, 5~8 parts of rhizoma zingiberis, 10~15 parts of Poria cocos, Siraitia grosvenorii 8~
12 parts and 5~8 parts of Radix Glycyrrhizae.
2. it is according to claim 1 treatment constipation-predominant of irritable bowel syndrome Chinese medicine composition, which is characterized in that including with
The raw material of lower parts by weight proportion: 8~10 parts of radix bupleuri, 8~10 parts of the dried immature fruit of citron orange, 11~14 parts of Radix Paeoniae Alba, 8~10 parts of fructus cannabis, betel nut 5
~7 parts, 5~7 parts of the coptis, 9~11 parts of hairy euphorbia, 9~11 parts of fiveleaf akebia fruit, 5~7 parts of chingma abutilon seed, 5~7 parts of rhizoma zingiberis, Poria cocos 11~
14 parts, 9~11 parts of Siraitia grosvenorii and 5~7 parts of Radix Glycyrrhizae.
3. it is according to claim 2 treatment constipation-predominant of irritable bowel syndrome Chinese medicine composition, which is characterized in that including with
The raw material of lower parts by weight proportion: 9 parts of radix bupleuri, 12 parts of Radix Paeoniae Alba, 9 parts of fructus cannabis, 6 parts of betel nut, 6 parts of the coptis, is flown upward at 9 parts of the dried immature fruit of citron orange
10 parts of grass, 10 parts of akebiae, 6 parts of chingma abutilon seed, 6 parts of rhizoma zingiberis, 12 parts of Poria cocos, 10 parts of Siraitia grosvenorii and 6 parts of Radix Glycyrrhizae.
4. a kind of preparation method for the Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, which is characterized in that the preparation side
Method are as follows: by radix bupleuri, the dried immature fruit of citron orange, Radix Paeoniae Alba, fructus cannabis, betel nut, the coptis, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, Siraitia grosvenorii
After crushing respectively with Radix Glycyrrhizae, each raw material powder is weighed by the raw material proportioning in any one of claims 1 to 3 Chinese medicine composition
End, mixing to get.
5. a kind of preparation method for the Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, which is characterized in that press claim 1
Raw material proportioning in any one of~3 Chinese medicine compositions weighs each raw material, mixes, extract to get.
6. the preparation method of the Chinese medicine composition for the treatment of constipation-predominant of irritable bowel syndrome according to claim 5, feature
It is, the operation of the extraction is first to be extracted with water, then the ethyl alcohol for being 65~95% with concentration expressed in percentage by volume extracts, and merging mentions
Take liquid.
7. the preparation method of the Chinese medicine composition for the treatment of constipation-predominant of irritable bowel syndrome according to claim 6, feature
It is, the operation of the extraction further includes by the concentration of gained extracting solution, drying.
8. a kind of preparation method for the Chinese medicine composition for treating constipation-predominant of irritable bowel syndrome, which is characterized in that the preparation side
Method are as follows: weigh each raw material by the raw material proportioning in any one of claims 1 to 3 Chinese medicine composition, extract respectively, be made and mention
Take object powder, by the extract powder mix to get.
9. the preparation method of the Chinese medicine composition for the treatment of constipation-predominant of irritable bowel syndrome according to claim 8, feature
It is, extracts the operation of the radix bupleuri are as follows: it is decocted with the ethyl alcohol that concentration expressed in percentage by volume is 45~65% and extracts 2~3 times, every time 20
~30min, merging filtrate, concentration, drying are to get bupleurum extract powder；
Extract the operation of the dried immature fruit of citron orange are as follows: it uses water boiling and extraction 2~3 times, 20~40min, merging filtrate, are concentrated, are dry every time,
Up to Bitter Orang P.E powder.
10. the preparation method of the Chinese medicine composition for the treatment of constipation-predominant of irritable bowel syndrome according to claim 9, feature
It is, with water to the Radix Paeoniae Alba, fructus cannabis, betel nut, hairy euphorbia, fiveleaf akebia fruit, chingma abutilon seed, rhizoma zingiberis, Poria cocos, Siraitia grosvenorii and Radix Glycyrrhizae point
It indescribably takes, the coptis is extracted with the ethyl alcohol that concentration expressed in percentage by volume is 45~65%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910150515.2A CN109731092A (en) | 2019-02-28 | 2019-02-28 | A kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910150515.2A CN109731092A (en) | 2019-02-28 | 2019-02-28 | A kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109731092A true CN109731092A (en) | 2019-05-10 |
Family
ID=66368768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910150515.2A Pending CN109731092A (en) | 2019-02-28 | 2019-02-28 | A kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109731092A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
-
2019
- 2019-02-28 CN CN201910150515.2A patent/CN109731092A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430999A (en) * | 2003-01-28 | 2003-07-23 | 南京师范大学 | Chinese herbal medicine combination for treating disease of disorder of bowels's function and its product |
Non-Patent Citations (1)
| Title |
|---|
| 赵润元等: "基于HPA轴探讨通腑降浊方治疗便秘型肠易激综合征模型大鼠的作用机制", 《中华中医药杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101732683A (en) | Chinese medicinal preparation for treating facial chloasma and preparation method thereof | |
| CN101249235B (en) | Chinese medicine for curing esophagus cancer and method of preparing the same | |
| CN104740222A (en) | Traditional Chinese medicine for treating leucoderma | |
| CN103495040A (en) | Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof | |
| CN103656535A (en) | Chinese medicinal composition for treating hyperlipidemia and preparation method thereof | |
| CN103816519A (en) | Spleen-strengthening dampness-removing traditional Chinese medicine composition and preparation method thereof | |
| CN105727145A (en) | Traditional Chinese medicine drug for treating spleen deficiency phlegm-dampness syndrome type hyperlipidaemia | |
| CN103735943A (en) | Medicament composition for treating diarrhea and preparation method and application thereof | |
| CN102441144B (en) | Traditional Chinese medicament for treating infantile malnutrition | |
| CN106038820A (en) | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof | |
| WO2017124826A1 (en) | Traditional chinese medicinal product for treating liver qi stagnation type premenstrual tension and syndrome | |
| CN106039196B (en) | A pharmaceutical composition for treating hyperlipidemia | |
| CN104398912A (en) | Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine | |
| CN103330259A (en) | Food composition with functions of nourishing yin, moisturizing lung and clearing way heat and preparation method thereof | |
| CN102805834A (en) | Drug for curing gastritis and preparation method thereof | |
| CN102526211B (en) | Composition of oral medicine for treating constipation and preparation technology | |
| CN109731092A (en) | A kind of Chinese medicine composition and preparation method thereof for treating constipation-predominant of irritable bowel syndrome | |
| CN105233078A (en) | Traditional Chinese medicine composition for treating viral hepatitis | |
| CN105267818A (en) | Traditional Chinese medicine composition for treating epigastric pain and preparation method thereof | |
| CN110720527A (en) | Traditional Chinese medicine weight-losing tea | |
| CN112386634A (en) | Traditional Chinese medicine composition for treating senile constipation | |
| CN103877484A (en) | Traditional Chinese medicine oral liquid for treating oral liquid | |
| CN103735942A (en) | Medicament composition for treating dysentery as well as preparation method and use of medicament composition | |
| CN103705856B (en) | For preventing the Chinese medicine composition of chemicotherapy acute radio-reaction | |
| CN102579787A (en) | Traditional Chinese medicine composition for treating chronic gastritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190510 |
|
| RJ01 | Rejection of invention patent application after publication |