CN109675068A - 一种具有消毒功能的医用超声耦合剂及其制备方法 - Google Patents
一种具有消毒功能的医用超声耦合剂及其制备方法 Download PDFInfo
- Publication number
- CN109675068A CN109675068A CN201910143213.2A CN201910143213A CN109675068A CN 109675068 A CN109675068 A CN 109675068A CN 201910143213 A CN201910143213 A CN 201910143213A CN 109675068 A CN109675068 A CN 109675068A
- Authority
- CN
- China
- Prior art keywords
- coupling agent
- ultrasonic coupling
- solution
- medical ultrasonic
- sterilizing function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007822 coupling agent Substances 0.000 title claims abstract description 32
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000008213 purified water Substances 0.000 claims abstract description 12
- 229920001577 copolymer Polymers 0.000 claims abstract description 10
- VAVMMEMXCQCWCG-UHFFFAOYSA-N CN(C)CCS(O)(=O)=O.C=CC(N)=O.N Chemical compound CN(C)CCS(O)(=O)=O.C=CC(N)=O.N VAVMMEMXCQCWCG-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- ZXPLGLMEXWSLCX-UHFFFAOYSA-N 2-chloro-3,5-dimethylphenol Chemical compound CC1=CC(C)=C(Cl)C(O)=C1 ZXPLGLMEXWSLCX-UHFFFAOYSA-N 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 3
- -1 D-pantothenyl Chemical group 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 229960000458 allantoin Drugs 0.000 claims description 3
- 238000013329 compounding Methods 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 10
- 239000000645 desinfectant Substances 0.000 abstract description 6
- 230000008878 coupling Effects 0.000 abstract description 3
- 238000010168 coupling process Methods 0.000 abstract description 3
- 238000005859 coupling reaction Methods 0.000 abstract description 3
- 230000009972 noncorrosive effect Effects 0.000 abstract description 3
- 229920000260 silastic Polymers 0.000 abstract description 2
- 230000006870 function Effects 0.000 description 15
- 239000000523 sample Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 5
- CFAFEJHONLMPQY-UHFFFAOYSA-N beta-Dimethylamino-aethan-alpha-sulfonsaeure Natural products CN(C)CCS(O)(=O)=O CFAFEJHONLMPQY-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 125000003827 glycol group Chemical group 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002152 chlorhexidine acetate Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000000976 ink Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/055—Phenols the aromatic ring being substituted by halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Radiology & Medical Imaging (AREA)
- Toxicology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明涉及一种具有消毒功能的医用超声耦合剂及其制备方法。该超声耦合剂,包括有效成分为:4‑氯‑3,5‑二甲基苯酚、丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物、聚乙二醇、护肤剂和纯化水。本发明所述医用消毒超声耦合剂,保持了传统医用超声耦合剂的性状和耦合功能,选择对人体和环境无害、对硅橡胶制品无腐蚀性的消毒杀菌剂4‑氯‑3,5‑二甲基苯酚制备出透明凝胶状的具有杀菌消毒功能的医用超声耦合剂。
Description
技术领域
本发明涉及一种具有消毒功能的医用超声耦合剂及其制备方法,属于医药化工的技术领域。
背景技术
医用超声耦合剂是目前临床上广泛应用的试剂,其功能是加强超声探头和人体皮肤之间的耦合,隔绝超声探头和被***位皮肤之间的空气,使声波传导不受空气的影响而衰减,以达到准确清晰的检查结果,为医生的正确诊断提供依据。
超声检查过程中,超声探头在病人之间高频率反复使用,通常只是在病人使用后做简单擦拭,超声探头成为传播疾病的传播良好载体,容易使被检查者感染致病菌,存在很大的交叉感染的风险。目前的医用超声耦合剂中一般都添加有杀菌剂进行灭菌达到减少交叉感染的目的。
现有技术中具有消毒功能的耦合剂多以凝胶基质交联聚丙烯酸树脂、海藻酸钠、聚丙烯酸钠与消毒剂三氯生、醋酸氯己定、季铵盐等配伍,实现杀菌消毒功能。这些消毒剂或水溶性差,或与凝胶基质具有配伍禁忌,较高剂量使用会影响凝胶产品的透明度、安全性与稳定性。
因此,研究开发安全、稳定,满足临床使用要求的具有消毒功能的超声耦合剂,对于临床超声检查具有重要意义。
发明内容
针对现有技术的不足,本发明提供一种具有消毒功能的医用超声耦合剂。
本发明还提供一种上述具有消毒功能的医用超声耦合剂的制备方法。
术语说明:
4-氯-3,5-二甲基苯酚:分子式,C8H9ClO,用于乳剂、化妆品、皮革、油墨、胶合板等作防霉防腐剂,医药上常用皮肤消毒剂。
丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物:白色粉末,用于透明体系的凝胶剂和水包油乳液的增稠剂。
纯化水:饮用水经蒸馏法、离子交换法、反渗透法或其他适宜的方法制得的供药用的水,不含任何添加剂。
本发明的技术方案为:
一种具有消毒功能的医用超声耦合剂,包括有效成分的重量百分比为:4-氯-3,5-二甲基苯酚0.1~2.0%、丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物0.5~1.2%、聚乙二醇5.0~10.0%、护肤剂0.5~3.0%,余量为纯化水。
4-氯-3,5-二甲基苯酚的作用是杀灭细菌、霉菌和病毒;丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物的作用是形成水溶性高分子凝胶;聚乙二醇的作用是作为溶剂溶解消毒剂;
根据本发明优选的,所述护肤剂为维生素E、尿囊素和D-泛醇中的一种或多种的复配;复配比例为任意比例。
一种具有消毒功能的医用超声耦合剂的制备方法,包括如下步骤:
1)按重量百分比称取丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物,并加入至纯化水中,搅拌至完全溶解,得到溶液A,备用;
2)按重量百分比称取4-氯-3,5-二甲基苯酚,溶于相应重量百分比的聚乙二醇中,得到溶液B,备用;
3)按重量百分比称取护肤剂,并分散到纯化水中,得到溶液C,备用;
4)在搅拌状态下,依次将所述溶液B、溶液C加入到所述溶液A中,并按重量百分比补足纯化水,调节pH值至5.5~8.0,继续搅拌均匀,得到无色透明的凝胶,即超声耦合剂;
5)灌装。
根据本发明优选的,所述步骤4)中搅拌状态的搅拌速度控制在50~70r/min。速度太慢,混合不均匀;速度太快,容易产生气泡,从而影响产品的性状。
本发明的有益效果为:
1.本发明所述医用消毒超声耦合剂,保持了传统医用超声耦合剂的性状和耦合功能,选择对人体和环境无害、对硅橡胶制品无腐蚀性的消毒杀菌剂4-氯-3,5-二甲基苯酚制备出透明凝胶状的具有杀菌消毒功能的医用超声耦合剂;
本发明配方所有原料在使用范围内经验证均是对人体和环境安全、无害的产品;生产的超声耦合剂符合YY0299-2016《医用超声耦合剂》的行业标准,对人体无毒、无致敏作用,对皮肤无刺激,对医用超声探头无腐蚀性与溶胀性,同时具有杀灭细菌、霉菌、病毒等病原微生物的功能;在超声诊疗过程中,既可作为耦合剂使用,在杀菌同时又能对超声探头随时进行消毒,使用方便,有效降低医用超声诊疗过程中可能带来的交叉感染风险;
2.本发明所述医用消毒超声耦合剂,所需原料常见易得,制造设备为普通容器、搅拌装置,自动罐装机等,制备工艺简单。
附图说明
图1为本发明所述本发明所述医用消毒超声耦合剂的制备流程图。
具体实施方式
下面结合实施例和说明书附图对本发明做进一步说明,但不限于此。
实施例1
一种具有消毒功能的医用超声耦合剂,100g中包括有效成分的重量为:4-氯-3,5-二甲基苯酚1g、丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物1g、聚乙二醇10g、护肤剂2g,余量为纯化水。
4-氯-3,5-二甲基苯酚的作用是杀灭细菌、霉菌和病毒;丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物的作用是形成水溶性高分子凝胶;聚乙二醇的作用是作为溶剂溶解消毒剂;
其中,所述护肤剂为维生素E、尿囊素和D-泛醇按1:1:2比例的复配。
实施例2
如图1所示。
实施例1所述具有消毒功能的医用超声耦合剂的制备方法,包括如下步骤:
1)称取丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物1g,并加入至纯化水中,搅拌至完全溶解,得到溶液A,备用;
2)称取4-氯-3,5-二甲基苯酚1g,溶于10g聚乙二醇中,得到溶液B,备用;
3)称取护肤剂2g,并分散到纯化水中,得到溶液C,备用;
4)在搅拌状态下,依次将所述溶液B、溶液C加入到所述溶液A中,并按重量百分比补足纯化水,调节pH值至5.5~8.0,继续搅拌均匀,得到无色透明的凝胶,即超声耦合剂;
5)灌装。
其中,所述步骤4)中搅拌状态的搅拌速度控制在50~70r/min。速度太慢,混合不均匀;速度太快,容易产生气泡,从而影响产品的性状。
对本实施例制得的医用消毒超声耦合剂,的性能指标、卫生指标和功能指标进行了抽样检测,检测结果符合要求。检测结果见下表:
通过上述数据可以得出,按《消毒技术规范》(2002年版)和YY0299-2016医用超声耦合剂的要求进行测定,产品性能测试的指标都符合要求。
Claims (4)
1.一种具有消毒功能的医用超声耦合剂,其特征在于,包括有效成分的重量百分比为:4-氯-3,5-二甲基苯酚0.1~2.0%、丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物0.5~1.2%、聚乙二醇5.0~10.0%、护肤剂0.5~3.0%,余量为纯化水。
2.根据权利要求1所述的具有消毒功能的医用超声耦合剂,其特征在于,所述护肤剂为维生素E、尿囊素和D-泛醇中的一种或多种的复配;复配比例为任意比例。
3.一种如权利要求1或2所述的具有消毒功能的医用超声耦合剂的制备方法,其特征在于,包括如下步骤:
1)按重量百分比称取丙烯酰胺二甲基牛磺酸铵/乙烯基吡咯烷酮共聚物,并加入至纯化水中,搅拌至完全溶解,得到溶液A,备用;
2)按重量百分比称取4-氯-3,5-二甲基苯酚,溶于相应重量百分比的聚乙二醇中,得到溶液B,备用;
3)按重量百分比称取护肤剂,并分散到纯化水中,得到溶液C,备用;
4)在搅拌状态下,依次将所述溶液B、溶液C加入到所述溶液A中,并按重量百分比补足纯化水,调节pH值至5.5~8.0,继续搅拌均匀,得到无色透明的凝胶,即超声耦合剂;
5)灌装。
4.根据权利要求3所述的医用超声耦合剂的制备方法,其特征在于,所述步骤4)中搅拌状态的搅拌速度控制在50~70r/min。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910143213.2A CN109675068A (zh) | 2019-02-26 | 2019-02-26 | 一种具有消毒功能的医用超声耦合剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910143213.2A CN109675068A (zh) | 2019-02-26 | 2019-02-26 | 一种具有消毒功能的医用超声耦合剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109675068A true CN109675068A (zh) | 2019-04-26 |
Family
ID=66197306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910143213.2A Pending CN109675068A (zh) | 2019-02-26 | 2019-02-26 | 一种具有消毒功能的医用超声耦合剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109675068A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114350447A (zh) * | 2022-01-11 | 2022-04-15 | 山东科宏医疗科技有限公司 | 一种核酸污染清除剂及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101773673A (zh) * | 2010-03-18 | 2010-07-14 | 薛海燕 | 医用消毒超声耦合剂及其制备方法 |
CN102218149A (zh) * | 2010-04-13 | 2011-10-19 | 舒朝锋 | 一种消毒杀菌型医用超声耦合剂及其制备工艺 |
-
2019
- 2019-02-26 CN CN201910143213.2A patent/CN109675068A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101773673A (zh) * | 2010-03-18 | 2010-07-14 | 薛海燕 | 医用消毒超声耦合剂及其制备方法 |
CN102218149A (zh) * | 2010-04-13 | 2011-10-19 | 舒朝锋 | 一种消毒杀菌型医用超声耦合剂及其制备工艺 |
Non-Patent Citations (1)
Title |
---|
鄢海燕等: "《药剂学》", 31 January 2018, 江苏凤凰科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114350447A (zh) * | 2022-01-11 | 2022-04-15 | 山东科宏医疗科技有限公司 | 一种核酸污染清除剂及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104771331B (zh) | 一种透明质酸弹性体及其应用 | |
US6302848B1 (en) | In vivo biocompatible acoustic coupling media | |
CN101716354B (zh) | 一种超声耦合剂 | |
CN100542615C (zh) | 具有消毒杀菌功能的医用超声耦合剂及其制备方法 | |
CN105536005B (zh) | 一种固态医用超声耦合贴片及其制备方法 | |
CN104208726B (zh) | 一种壳聚糖季铵盐耦合剂及其制备方法 | |
CN102580121B (zh) | 一种医用消毒耦合剂 | |
CN105999312A (zh) | 医用消毒超声耦合剂及其制备方法 | |
CN102580122B (zh) | 一种医用消毒耦合剂的制备方法 | |
CN109675068A (zh) | 一种具有消毒功能的医用超声耦合剂及其制备方法 | |
CN102204880A (zh) | 一种妇科外用消毒液凝胶剂及其制备方法 | |
US3965908A (en) | Synthetic physiological mucus | |
Graham et al. | Cellular toxicity of urinary catheters | |
KR101725311B1 (ko) | 초음파 검사용 수용성 하이드로겔 패드 조성물 및 그 조성물을 이용한 패드 제조방법 | |
CN110585450B (zh) | 医用消毒杀菌型超声耦合剂 | |
CN108939095A (zh) | 抑菌型超声耦合剂的制备方法及其产品和应用 | |
WO2007073643A1 (fr) | Agent de couplage ultrasonore, son procede de preparation et recipient le contenant | |
CN116549675A (zh) | 一种免刺激型医用超声耦合剂及其制备方法 | |
CN102218149A (zh) | 一种消毒杀菌型医用超声耦合剂及其制备工艺 | |
CN105708727B (zh) | 一种保湿美白祛斑除痘抑菌敷料及其制备方法 | |
CN109675067A (zh) | 一种医用消毒超声耦合剂及其制备方法 | |
CN102716503A (zh) | 一种医用超声耦合剂及其制备方法 | |
Taguchi et al. | Evaluation of tumor tissue fixation effects of formulation modified Mohs pastes in mice and their water-absorbing properties | |
CN109675069A (zh) | 一种医用消毒超声耦合剂及其制备方法 | |
CN113069561A (zh) | 一种具有消毒功能的医用超声耦合剂及制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190426 |
|
RJ01 | Rejection of invention patent application after publication |