CN109674929A - A kind of black raspberry fruit freeze-dried powder composite oral liquid prescription and preparation method thereof - Google Patents
A kind of black raspberry fruit freeze-dried powder composite oral liquid prescription and preparation method thereof Download PDFInfo
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- CN109674929A CN109674929A CN201710972246.9A CN201710972246A CN109674929A CN 109674929 A CN109674929 A CN 109674929A CN 201710972246 A CN201710972246 A CN 201710972246A CN 109674929 A CN109674929 A CN 109674929A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Abstract
The invention discloses a kind of black raspberry fruit freeze-dried powder composite oral liquid prescriptions and preparation method thereof, composite oral liquid prescription, the component including following parts by weight: 30-50 parts of black raspberry fruit freeze-dried powder, 5-10 parts of green asparagus extract, 20-50 parts of inulin, 0.1-0.4 parts of Momordica-Glycosides, 0.3 part of edible salt, 2 parts of compound stabilizer, 1000-2000 parts of drinking water.The compound stabilizer includes CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum.The present invention not only avoids the deficiency of single-activity substance using the synergistic effect between four kinds of metabolites, enhances the function and effect of the assistant regulating and controlling to the metabolism class disease such as blood pressure and blood lipoid.Manufacture craft of the present invention is simple, ensure that the mouthfeel of oral solution, reduces the loss of nutritional ingredient, and raw material sources are extensive, has wide exploitation and application prospect.It can also make its mutually coordinated effect, humidification effect.
Description
Technical field
The present invention relates to area of pharmacology, specifically a kind of black raspberry fruit freeze-dried powder composite oral liquid prescription and its
Preparation method.
Background technique
Black raspberry belongs to rosaceae and hooks outstanding son category berry, is known as " fruit of life " in the U.S., has in the international market " yellow
The title of Jinsui River fruit, noble's fruit ", existing research confirm to contain a large amount of active material in black raspberry, can be divided according to chemical structure
Are as follows: phenolic acid class, flavonoids, procyanidine, tannin, styrene, lignanoid, triterpene and sterol.It is the most universal in black raspberry fruit
Compound be procyanidine and ellagic acid class, extract is supported in prevention and treatment carbohydrate metabolism disturbance, the damage of β islet cells and insulin
There is remarkable effect in terms of resisting the type-2 diabetes mellitus for main feature.
Asparagus also known as asparagus, asparagus, green asparagus, are Asparagaceae Asparagus herbaceos perennials, in the world
The laudatory title of " kings of vegetables " is enjoyed in the market, and asparagus contains the indispensable amino acid of human body, minerals and other a variety of nutrition
Element has antitumor, anti-mutation, anti-aging, drop blood also containing various bioactive components such as gleditsia sinensis glucoside and flavonoids
The multiple biological functions such as sugar, immunological regulation, nutritionist and vegetarian diet circle personage claim it to be healthy food.Research finds, reed
Bamboo shoot have different degrees of blood sugar reducing function to hyperglycemic subject.
Inulin, also known as synanthrin, one of the storing mode as plant energy are more than in being widely distributed for nature
Its content can be found in 30000 kinds of plants, and as their energy reserve.Inulin is white or milky amorphous powder,
Slightly sweet taste, water-soluble, 2003, U.S. FDA had confirmed that inulin is GRAS (generally recognized as safe substance), and day, effective intake was
5g, recommending maximum daily intaking amount is 15~20g.Inulin will not be by body enzyme hydrolysis at monosaccharide, because without right in upper intestines
Blood glucose level and insulin content impact, and inulin can also be such that the viscosity of small intestine contents increases as a kind of water-soluble fibre
Add, and increase the thickness of the non-agitation layer of intestinal mucosa, to delay and hinder the absorption of glucose, plays the function for reducing blood glucose
Energy.Inulin is used as one of diabetes patient's special food already.
What Siraitia grosvenorii played a major role to various diseases is exactly 300 times than granulated sugar sweet tea contained in fruit of substance --- arhat
Fruit sweet tea glucoside, scientific name are " cucurbitane-glycoside ", are one of the sweet substances other than the granulated sugar for belonging to triterpene system, due to Siraitia grosvenorii
Sweet taste is a kind of non-sugar ingredient, so diabetes patient can also take.There is Siraitia grosvenorii postprandial blood sugar to generate low, blood glucose holding stabilization
The characteristics of, help that postprandial blood sugar is maintained to stablize.And Momordica-Glycosides has during promoting pancreatic beta cell excreting insulin
Significantly effect.Therefore, Momordica-Glycosides has wide practical use in terms of reducing blood sugar for human body.
CMC is carboxymethyl cellulose, and cellulose obtains carboxymethyl cellulose (CMC) after carboxy methylation, aqueous solution tool
Have thickening, film forming, gluing, water tariff collection, colloid protection, emulsification and suspend the effects of, be widely used in petroleum, food, medicine,
The industries such as textile and paper are one of most important cellulose ethers.
Black raspberry fruit freeze-dried powder production method is the black raspberry fruit for taking freeze-drying, is polished by high speed disintegrator, is crushed
30 times, each 10s, 160 meshes are crossed, the black raspberry fruit freeze-dried powder of fine particle is formed.
Summary of the invention
The purpose of the present invention is to provide a kind of black raspberry fruit freeze-dried powder composite oral liquid prescription and preparation method thereof, four
Kind plant metabolites have facilitation to the reduction of blood glucose, using the synergistic effect between four kinds of metabolites, not only avoid
The deficiency of single-activity substance, can also make its mutually coordinated effect, humidification effect.
In order to achieve the above objectives, present invention employs following technical solution, a kind of compound mouths of black raspberry fruit freeze-dried powder
Liquid prescription is taken, the component including following parts by weight: 30-50 parts of black raspberry fruit freeze-dried powder, 5-10 parts of green asparagus extract, chrysanthemum
20-50 parts of powder, 0.1-0.4 parts of Momordica-Glycosides, 0.3 part of edible salt, 2 parts of compound stabilizer, 1000-2000 parts of drinking water.
The compound stabilizer includes CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum.
In order to reach above-mentioned another object, present invention employs following technical solution, a kind of black raspberry fruit freeze-dried powder is multiple
Close oral liquor, comprising the following steps:
1), weigh the component of following parts by weight respectively: 30-50 parts of black raspberry fruit freeze-dried powder, 5-10 parts of green asparagus extract,
20-50 parts of inulin, 0.1-0.4 parts of Momordica-Glycosides, 0.3 part of edible salt, 2 parts of compound stabilizer, 1000-2000 parts of drinking water,
The compound stabilizer includes CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum；
2) CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum, are taken, three kinds of stabilizers are added to drinking water kind, and water-bath is 60 DEG C,
120r/min is stirred continuously, and is dissolved until each stabilizer mixes completely in water, until no obvious bulk and particle；
3) 30-50 parts of black raspberry fruit freeze-dried powder, are added in the above mixed liquor kind；And water transfer bath temperature is 50 DEG C, 120r/min
It is stirred continuously, until adding 5-10 parts of green asparagus extract, chrysanthemum after black raspberry fruit freeze-drying powder particles are completely dissolved in water
20-50 parts of powder, 0.1-0.4 parts of Momordica-Glycosides, 0.3 part of edible salt, are sufficiently stirred, and mix, bottled, and sterilizing is compound to get arriving
Oral solution.
The black raspberry fruit freeze-dried powder production method is the black raspberry fruit for taking freeze-drying, is polished by high speed disintegrator,
It crushes 30 times, each 10s, crosses 160 meshes, form the black raspberry fruit freeze-dried powder of fine particle.
Compared to the prior art, the invention has the following advantages:
Black raspberry fruit freeze-dried powder composite oral liquid, by black raspberry fruit freeze-dried powder, inulin, mogroside and green asparagus extract
Common synergistic effect, regulates and controls the reduction of blood sugar concentration.Active principle is black raspberry fruit freeze-dried powder, inulin, Siraitia grosvenorii
Glucoside and green asparagus extract.Preparation formulation is oral solution type.Black raspberry fruit freeze-dried powder, green asparagus extract, inulin and arhat
The composite oral liquid of fruit glucoside composition is as the application for adjusting blood pressure and blood lipoid concentration health care product.The composition is used to improve body battalion
On the basis of the situation of supporting, has the function that regulating and controlling blood sugar, blood lipid, eliminates hungry, anti-aging.
The present invention reduces Blood Glucose concentration using Four Plants metabolite.Black raspberry fruit freeze-dried powder contains largely
Active material has remarkable effect to the protection of metabolism, the damage of islet cells of blood glucose.Asparagus is different to hyperglycemic patients
The blood sugar reducing function inulin of degree is fructose polymer, is not decomposed, is not absorbed substantially by human oral cavity, stomach and small intestine, after intake
It will not cause the fluctuation of blood glucose level, there are also certain antidiabetic function, mogroside, which also has, to be adjusted blood glucose and maintain blood glucose
The stable function of concentration.Four Plants metabolite has facilitation to the reduction of blood glucose, using between four kinds of active materials
Synergistic effect not only avoids the deficiency of single-activity substance, makes its mutually coordinated effect while reducing dosage, increases
The function and effect of the strong assistant regulating and controlling to the metabolism class disease such as blood pressure and blood lipoid.Manufacture craft of the present invention is simple, ensure that oral
The mouthfeel of liquid reduces the loss of nutritional ingredient, and raw material sources are extensive, has wide exploitation and application prospect.
Specific embodiment
Embodiment 1:
In laboratory, compound stabilizer is added in 1000 portions of drinking water, wherein CMC1 parts, 0.5 part of carragheen, xanthan gum
0.5 part.Water-bath is 60 DEG C, and 120r/min is stirred continuously, until each stabilizer mixes completely in water, no obvious bulk and
Until grain.30 parts of black raspberry fruit freeze-dried powder is added in the above mixed liquor kind, and water transfer bath temperature is 50 DEG C, 120r/min is continuous
Stirring, until being added 20 parts of inulin content, sweet Momordica grosvenori salidroside content after black raspberry fruit freeze-drying powder particles are completely dissolved in water
0.1 part, 5 parts of green asparagus extract, eat 0.3 part of salt content.It is sufficiently stirred, mixes, bottled, sterilizing takes orally to get to compound
Liquid.
Embodiment 2:
In laboratory, compound stabilizer is added in 2000 portions of drinking water, wherein CMC1 parts, 0.5 part of carragheen, xanthan gum
0.5 part.Water-bath is 60 DEG C, and 120r/min is stirred continuously, until each stabilizer mixes completely in water, no obvious bulk and
Until grain.50 parts of black raspberry fruit freeze-dried powder is added in the above mixed liquor kind, and water transfer bath temperature is 50 DEG C, 120r/min is continuous
Stirring, until being added 50 parts of inulin content, sweet Momordica grosvenori salidroside content after black raspberry fruit freeze-drying powder particles are completely dissolved in water
0.25 part, 10 parts of green asparagus extract, eat 0.3 part of salt content.It is sufficiently stirred, mixes, it is bottled, it sterilizes to get compound mouth is arrived
Take liquid.
Embodiment 3:
In laboratory, compound stabilizer is added in 1500 portions of drinking water, wherein CMC1 parts, 0.5 part of carragheen, xanthan gum
0.5 part.Water-bath is 60 DEG C, and 120r/min is stirred continuously, until each stabilizer mixes completely in water, no obvious bulk and
Until grain.40 parts of black raspberry fruit freeze-dried powder is added in the above mixed liquor kind, and water transfer bath temperature is 50 DEG C, 120r/min is continuous
Stirring, until being added 30 parts of inulin content, sweet Momordica grosvenori salidroside content after black raspberry fruit freeze-drying powder particles are completely dissolved in water
0.4 part, 7 parts of green asparagus extract, eat 0.3 part of salt content.It is sufficiently stirred, mixes, bottled, sterilizing takes orally to get to compound
Liquid.
Embodiment 4:
In laboratory, compound stabilizer is added in 1000 portions of drinking water, wherein CMC1 parts, 0.5 part of carragheen, xanthan gum
0.5 part.Water-bath is 60 DEG C, and 120r/min is stirred continuously, until each stabilizer mixes completely in water, no obvious bulk and
Until grain.35 parts of black raspberry fruit freeze-dried powder is added in the above mixed liquor kind, and water transfer bath temperature is 50 DEG C, 120r/min is continuous
Stirring, until being added 30 parts of inulin content, sweet Momordica grosvenori salidroside content after black raspberry fruit freeze-drying powder particles are completely dissolved in water
0.1 part, 8 parts of green asparagus extract, eat 0.3 part of salt content.It is sufficiently stirred, mixes, bottled, sterilizing takes orally to get to compound
Liquid.
Embodiment 5:
In laboratory, compound stabilizer is added in 1000 portions of drinking water, wherein CMC1 parts, 0.5 part of carragheen, xanthan gum
0.5 part.Water-bath is 60 DEG C, and 120r/min is stirred continuously, until each stabilizer mixes completely in water, no obvious bulk and
Until grain.45 parts of black raspberry fruit freeze-dried powder is added in the above mixed liquor kind, and water transfer bath temperature is 50 DEG C, 120r/min is continuous
Stirring, until being added 40 parts of inulin content, sweet Momordica grosvenori salidroside content after black raspberry fruit freeze-drying powder particles are completely dissolved in water
0.25 part, 5 parts of green asparagus extract, eat 0.3 part of salt content.It is sufficiently stirred, mixes, bottled, sterilizing takes orally to get to compound
Liquid.
Embodiment 6:
In laboratory, compound stabilizer is added in 2000 portions of drinking water, wherein CMC1 parts, 0.5 part of carragheen, xanthan gum
0.5 part.Water-bath is 60 DEG C, and 120r/min is stirred continuously, until each stabilizer mixes completely in water, no obvious bulk and
Until grain.30 parts of black raspberry fruit freeze-dried powder is added in the above mixed liquor kind, and water transfer bath temperature is 50 DEG C, 120r/min is continuous
Stirring, until being added 50 parts of inulin content, sweet Momordica grosvenori salidroside content after black raspberry fruit freeze-drying powder particles are completely dissolved in water
0.4 part, 10 parts of green asparagus extract, eat salt content 0.3%.It is sufficiently stirred, mixes, bottled, sterilizing takes orally to get to compound
Liquid.
Main ingredient of the invention is black raspberry fruit freeze-dried powder, green asparagus extract, inulin, Momordica-Glycosides, four kinds
Different active substance combinations form.The dosage of single component is reduced meanwhile, it is capable to common chemiluminescence, to blood glucose
The reduction of concentration has significant adjusting.There are also reducing blood lipid, function anti-oxidant, anti-aging is immune with enhancing by the present invention.
The present invention is composite oral liquid, is rich in the various bioactivators such as amino acid, vitamin, inorganic salts, flavonoids,
The deficiency of its effect cannot be played comprehensively by overcoming single-activity substance, make four kinds of active principle synergistic effects, can efficiently, fastly
It is fast to reduce Blood Glucose concentration, serum lipid concentrations, eliminate the functions such as hungry and anti-aging, assign more application ranges.Together
When the natural products of four kinds of dual-purpose of drug and food is made up of related process quality-high and inexpensive, oral solution with health care function is people again
It is desired, edible natural plant metabolite oral solution had not only met the eating habit of Chinese, but also can be to certain diseases
It is taken precautions against.The present invention in the production process, ensure that the mouthfeel of oral solution, reduce nutrient loss, lasting medicine, nothing
Toxic side effect.
The foregoing is merely presently preferred embodiments of the present invention, non-to limit the scope of the patents of the invention, other are with this
The equivalence changes of patent of invention spirit should all belong to the scope of the patents of the invention.
Claims (4)
1. a kind of black raspberry fruit freeze-dried powder composite oral liquid prescription, which is characterized in that the component including following parts by weight: black
30-50 parts of fruit of raspberry freeze-dried powder, 20-50 parts of inulin, 0.1-0.4 parts of Momordica-Glycosides, is eaten 5-10 parts of green asparagus extract
0.3 part of salt, 2 parts of compound stabilizer, 1000-2000 parts of drinking water.
2. a kind of black raspberry fruit freeze-dried powder composite oral liquid prescription according to claim 1, which is characterized in that described multiple
Closing stabilizer includes CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum.
3. a kind of black raspberry fruit freeze-dried powder composite oral liquid preparation method, which comprises the following steps:
1), weigh the component of following parts by weight respectively: 30-50 parts of black raspberry fruit freeze-dried powder, 5-10 parts of green asparagus extract,
20-50 parts of inulin, 0.1-0.4 parts of Momordica-Glycosides, 0.3 part of edible salt, 2 parts of compound stabilizer, 1000-2000 parts of drinking water,
The compound stabilizer includes CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum；
2) CMC1 parts, 0.5 part of carragheen, 0.5 part of xanthan gum, are taken, three kinds of stabilizers are added to drinking water kind, and water-bath is 60 DEG C,
120r/min is stirred continuously, and is dissolved until each stabilizer mixes completely in water, until no obvious bulk and particle；
3) 30-50 parts of black raspberry fruit freeze-dried powder, are added in the above mixed liquor kind；And water transfer bath temperature is 50 DEG C, 120r/min
It is stirred continuously, until adding 5-10 parts of green asparagus extract, chrysanthemum after black raspberry fruit freeze-drying powder particles are completely dissolved in water
20-50 parts of powder, 0.1-0.4 parts of Momordica-Glycosides, 0.3 part of edible salt, are sufficiently stirred, and mix, bottled, and sterilizing is compound to get arriving
Oral solution.
4. a kind of black raspberry fruit freeze-dried powder composite oral liquid preparation method according to claim 3, which is characterized in that institute
Stating black raspberry fruit freeze-dried powder production method is the black raspberry fruit for taking freeze-drying, is polished by high speed disintegrator, is crushed 30 times,
Each 10s crosses 160 meshes, forms the black raspberry fruit freeze-dried powder of fine particle.
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| CN201710972246.9A CN109674929A (en) | 2017-10-18 | 2017-10-18 | A kind of black raspberry fruit freeze-dried powder composite oral liquid prescription and preparation method thereof |
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Citations (6)
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| CN101584439A (en) * | 2009-06-22 | 2009-11-25 | 大连工业大学 | Utilize vacuum freeze-drying method to produce the method for raspberry active freeze-dried powder and capsule |
| CN103142720A (en) * | 2013-02-27 | 2013-06-12 | 辽宁大学 | Application of black raspberry extract in preparing anti-diabetic medicine |
| CN103750328A (en) * | 2014-01-25 | 2014-04-30 | 山东黑尚莓生物技术发展股份有限公司 | Freeze-dried compound berry superfine powder and production method thereof |
| CN104146223A (en) * | 2014-05-30 | 2014-11-19 | 呼玛县天地山野产品有限责任公司 | Preparation method of raspberry lyophilized powder |
| CN106332971A (en) * | 2016-08-26 | 2017-01-18 | 安徽农业大学 | Processing method of Chinese yam and cow milk beverage |
| EP2844082B1 (en) * | 2012-07-24 | 2018-12-26 | Square Son Intellectual Property, LP | PROCESS For MAKING A REDUCED CALORIE BEVERAGE OR FOOD PRODUCT |
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2017
- 2017-10-18 CN CN201710972246.9A patent/CN109674929A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101584439A (en) * | 2009-06-22 | 2009-11-25 | 大连工业大学 | Utilize vacuum freeze-drying method to produce the method for raspberry active freeze-dried powder and capsule |
| EP2844082B1 (en) * | 2012-07-24 | 2018-12-26 | Square Son Intellectual Property, LP | PROCESS For MAKING A REDUCED CALORIE BEVERAGE OR FOOD PRODUCT |
| CN103142720A (en) * | 2013-02-27 | 2013-06-12 | 辽宁大学 | Application of black raspberry extract in preparing anti-diabetic medicine |
| CN103750328A (en) * | 2014-01-25 | 2014-04-30 | 山东黑尚莓生物技术发展股份有限公司 | Freeze-dried compound berry superfine powder and production method thereof |
| CN104146223A (en) * | 2014-05-30 | 2014-11-19 | 呼玛县天地山野产品有限责任公司 | Preparation method of raspberry lyophilized powder |
| CN106332971A (en) * | 2016-08-26 | 2017-01-18 | 安徽农业大学 | Processing method of Chinese yam and cow milk beverage |
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Effective date of registration: 20190603 Address after: 123003 No. 61, Group 3, Mawei Village, Liangjiazi Township, Zhangwu County, Fuxin City, Liaoning Province Applicant after: Zhao Hongshi Address before: 123 000 No. 54 East Street, Daleng Village, Daleng Town, Zhangwu County, Fuxin City, Liaoning Province Applicant before: Liaoning Harvey Nicks health food manufacturing Co., Ltd. |
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Application publication date: 20190426 |