CN109662903A - Have effects that prevent and treat the compound oily preparation and the preparation method and application thereof of acne - Google Patents
Have effects that prevent and treat the compound oily preparation and the preparation method and application thereof of acne Download PDFInfo
- Publication number
- CN109662903A CN109662903A CN201910165267.9A CN201910165267A CN109662903A CN 109662903 A CN109662903 A CN 109662903A CN 201910165267 A CN201910165267 A CN 201910165267A CN 109662903 A CN109662903 A CN 109662903A
- Authority
- CN
- China
- Prior art keywords
- preparation
- acne
- treat
- prevent
- effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to cosmetic technical fields, provide a kind of compound oily preparation and the preparation method and application thereof with prevention and treatment acne.A kind of preparation method of the compound oily preparation prevent and treat with acne after dissolution carboxylic acid, oligopeptides and solvent, is heated to 30-85 DEG C, adds coupling agent and be uniformly mixed, and insulation reaction 1.5-48 hour, up to being completely dissolved；The oligopeptides, carboxylic acid, solvent, the weight ratio between coupling agent are 0.08-2:1-20:75-98.8:0.12-3；The oligopeptides bond number containing peptide is 2-20.Have effects that prevent and treat the compound oily preparation of acne and its application the present invention also provides a kind of.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of compound oiliness with prevention and treatment acne
Preparation and the preparation method and application thereof.
Background technique
Loving beauty is part of human nature, particularly to the guys and dolls of prepuberty, they always wish by oneself
Beauty is presented to the relative, friend and colleague of oneself.But almost everyone is more or less in the world is perplexed by acne
It crosses.
The generation of acne mainly with hypersteatosis, pilosebaceous duct blocking, bacterium infection and inflammatory reaction etc.
Factor is closely related.The level of androgen especially testosterone in descendant's body that adolesces increases rapidly, promotes sebaceous glands development
And generate a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, and dyssebacia forms cutin
Bolt, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes mass propagation in hair follicle, the lipase that propionibacterium acnes generate
It decomposes sebum and generates free fatty acid, while chemotactic inflammatory cell and medium, finally induce and aggravate inflammatory reaction.
Skin lesion is apt to occur in face and upper chest and back.The non-inflammation skin of acne damage of acne shows as open and closed comedones.
The typical skin lesion of closed comedones (also known as hoary hair) is the colour of skin papule of about 1 mm in size, without obvious hair follicle opening.Open powder
Thorn (also known as blackhead) shows as dome-shaped papule with the hair follicle opening significantly expanded.Acne, which further develop, can evolve into various inflammation
The skin lesion of disease property shows as inflamed papules, warts, tubercle and tumour.Inflamed papules take on a red color, and 1~5 millimeter of diameter is differed；Warts
It is in the same size, it has been filled with white fester；Tubercle diameter is greater than 5 millimeters, and touching has scleroma and feeling of pain；The position of tumour is more
It is deep, it is filled with the mixture of fester and blood.These skin lesions can also merge to form big inflammatory patch and sinus etc..Inflammatory skin
Damage usually leaves pigmentation, erythema perstans, pitting or hypertrophic scar after subsiding.Clinically according to acne lesions property
Acne is divided into 3 degree, 4 grades: 1 grades (slight) with severity: only acne；2 grades (moderate): in addition to acne, there are also some inflammation
Property papule；3 grades (moderate): in addition to acne, there are also more inflamed papules or warts；4 grades (severe): except having acne, inflammatory mound
Outside rash and warts, nodosity, tumour or scar are gone back.The treatment of acne is always the problem of cosmetic field and field of medicaments.
Summary of the invention
It is an object of the invention to overcome the above-mentioned prior art, providing one kind has effects that prevent and treat acne
Compound oily preparation and the preparation method and application thereof.
In order to solve the above technical problems, invention uses technical solution as described below.One kind, which has, prevents and treats acne
The preparation method of the compound oily preparation of effect is heated to 30-85 DEG C, adds coupling after dissolving carboxylic acid, oligopeptides and solvent
Agent is uniformly mixed, and insulation reaction 1.5-48 hours, until being completely dissolved；
The oligopeptides, carboxylic acid, solvent, the weight ratio between coupling agent are 0.08-2:1-20:75-98.8:0.12-3；
The oligopeptides bond number containing peptide is 2-20.
Preferably, the solvent is white oil, synthesis saualane, comes out from the sub-arguments such as petroleum or coal saturated straight chain hydro carbons and big
In 6 carbon saturation cycloalkane and the saturated straight chain hydro carbons by adding hydrogen to obtain and it is greater than 6 carbon saturation cycloalkane, accumulated angle
Shark alkane, synthesizing polyisobutylene, synthesizing hydrogenated poly decene, the solid or liquid of hydrogenated polyolefins；Or it is straight for the saturation of plant origin
Catenanes and greater than 6 carbon saturation cycloalkane and the saturated straight chain hydro carbons by adding hydrogen to obtain and greater than 6 carbon are saturated cycloalkanes
Hydrocarbon, synthesis saualane, synthesizing polyisobutylene, synthesizing hydrogenated poly decene, the solid or liquid of hydrogenated polyolefins；Or it is big for total carbon number
In 8 monoester class compound, the solid of ether compound or liquid；Or for total carbon number greater than 8 silicon-containing compound solid or
Liquid；Or the solid or liquid of more ester type compounds for total carbon number greater than 20；It or is above-mentioned several mixture.
Preferably, the viscosity of the solvent is 10-20000cps.
Preferably, the hydroxyl of the carboxylic acid is in the position α and β of carboxylic acid.
Preferably, the molecular weight of the carboxylic acid is less than 2000.
Preferably, the coupling agent is one or more of neutralizer, solubilizer, transdermal agent, antioxidant, preservative
Mixture.
Preferably, the temperature of the heating is 32-66 DEG C.
Preferably, the reaction when it is 1.55-40 hours a length of.
It is a kind of to have effects that prevent and treat the compound oily preparation of acne, acne is prevented and treated using above-mentioned having
The preparation method of the compound oily preparation of effect is prepared.
A kind of application of the compound oily preparation prevent and treat with acne, above-mentioned having is prevented and treated
The compound oily preparation of acne effect is used to prepare cosmetics.
The beneficial effects of the present invention are:
Product of the invention solves the water solubility of carboxylic acid, while promoting the healing of damaged skin, especially few to blueness
The acne prevention in period in year plays a multiplier effect.
Specific embodiment
To make those skilled in the art that the purposes, technical schemes and advantages of invention be more clearly understood, below
Invention is further elaborated in conjunction with the embodiments.
Embodiment one
It is a kind of have effects that prevent and treat acne compound oily preparation preparation method, dissolution carboxylic acid, oligopeptides and
After solvent, it is heated to 30-85 DEG C, coupling agent is added and is uniformly mixed, insulation reaction 1.5-48 hours, until being completely dissolved；
The oligopeptides, carboxylic acid, solvent, the weight ratio between coupling agent are 0.08-2:1-20:75-98.8:0.12-3；
The oligopeptides bond number containing peptide is 2-20.
Carboxylic acid is a kind of long treatment nti-freckle bulk pharmaceutical chemicals, and pharmacology is mainly manifested in: 1. directly inhibit and kill skin
Skin surface and intrafollicular bacterium eliminate pathogen；2. Reverse transcriptase generates the enzyme process of dihydrotestosterone, dihydrotestosterone is reduced
The skin oil and fat that factor induces is excessive；3. the generation and effect of inhibitory activity oxygen radical, are conducive to anti-inflammatory；4. reducing Filamentous angle
Being combined for albumen, prevents follicular hyperkeratosis；5. destroying cell mitochondrial breathing, cell is inhibited to be combined, from
And inhibit cell Proliferation.So this product is as externally used antimicrobial agent, on skin various aerobic bacterias and anaerobic bacteria have inhibit and
Killing effect, the carboxylic acid ointment of local use 20% can substantially reduce the life of Propionibacterium class bacterium in skin bacterium and folliculus
It is long, and decline the free fatty acid content of skin surface lipid.Have to skin disease caused by various different pathogenies good
Antibacterial action.
But in terms for the treatment of and preventing acne, there is many defects and deficiencies.First, the antibacterial activity of carboxylic acid and
It absorbs, when general pH is below 3.0, this produces human skin and greatly stimulates, and the pH of normal skin is 5.8 or so.
Second, the effect in prevention acne is very unobvious, and prevents acne and be generally not the scope of medicine, and belong to cosmetics
Field.And cosmetics cannot generate side effect on ordinary meaning to human body, and product pH value general control is in people
The pH or so of body skin.And in such cases, it is that cannot tell on to the prevention of acne.Third, carboxylic acid low temperature slightly soluble
Yu Shui, high temperature are dissolved in water, cause compound oiliness preparations shaping difficult, so the drug and cosmetics of hydroxyl-containing acid are all considerably less.
Oligopeptides, especially two peptide, palmitoyl tripeptide 3 and four victory peptides are all water-soluble very good small-molecular peptides, are human body skins
The necessary raw material for the collagen that skin is combined.It is found in damaged skin research and skin metabolism research, oligopeptides is not
It respectively or need to further be decomposed by skin, but directly absorb and utilize, for repairing damaged skin and acceleration skin more
Newly there is very important meaning.
The present invention is that on this basis, carboxylic acid and oligopeptides by Chemical Physics, under given conditions, are combined
Oligopeptides carboxylic acid.Product of the invention solves the water solubility of carboxylic acid, while promoting the healing of damaged skin, especially
It plays a multiplier effect to the acne prevention of adolescence.
Preferably, the peptide bond number of the oligopeptides is 2-14, and best peptide bond number is 2-8.
Preferably, the solvent is white oil, synthesis saualane, comes out from the sub-arguments such as petroleum or coal saturated straight chain hydro carbons and big
In 6 carbon saturation cycloalkane and the saturated straight chain hydro carbons by adding hydrogen to obtain and it is greater than 6 carbon saturation cycloalkane, accumulated angle
Shark alkane, synthesizing polyisobutylene, synthesizing hydrogenated poly decene, the solid or liquid of hydrogenated polyolefins；Or it is straight for the saturation of plant origin
Catenanes and greater than 6 carbon saturation cycloalkane and the saturated straight chain hydro carbons by adding hydrogen to obtain and greater than 6 carbon are saturated cycloalkanes
Hydrocarbon, synthesis saualane, synthesizing polyisobutylene, synthesizing hydrogenated poly decene, the solid or liquid of hydrogenated polyolefins；Or it is big for total carbon number
In 8 monoester class compound, the solid of ether compound or liquid；Or for total carbon number greater than 8 silicon-containing compound solid or
Liquid；Or the solid or liquid of more ester type compounds for total carbon number greater than 20；It or is above-mentioned several mixture.Preferably,
The viscosity of the solvent is 10-20000cps, most preferably 300-12000cps.
Preferably, the hydroxyl of the carboxylic acid is in the position α and β of carboxylic acid.It is preferred that the molecular weight of the carboxylic acid is small
In 2000.Preferably, the coupling agent is one or more of neutralizer, solubilizer, transdermal agent, antioxidant, preservative
Mixture.
During the preparation process, it is preferable that the temperature of the heating is 32-66 DEG C, and optimum heating temperature is 32~48 DEG C.Institute
The duration for stating reaction is preferably 1.55-40 hours, and optimum reacting time is 2.0-36 hours.
Embodiment two
It is a kind of to have effects that prevent and treat the compound oily preparation of acne, using a kind of tool provided in embodiment one
There is the preparation method for the compound oily preparation for preventing and treating acne effect to be prepared.It can be also simply referred to as oligopeptides hydroxyl in the text
Acid.
Embodiment three
A kind of application of the compound oily preparation prevent and treat with acne, by tool provided in embodiment two
There is the compound oily preparation for preventing and treating acne effect to be used to prepare cosmetics.It can be according to the conventional work for preparing cosmetics
Skill is prepared into the cosmetics such as cleaning class, skin type and beautification class.Its prepare cosmetics can have stoste, body film, facial mask,
The dosage forms such as day cream, late frost, lipstick, foundation emulsion, eye shadow, toner and essence.According to preparing the common process of cosmetic product i.e.
It can be prepared into product.
The raw material components and proportion of cosmetics of the invention may is that
Compound oily preparation: 0.2-25 parts by weight；Matrix 60-88 parts by weight.
Preferably, the matrix is the emulsified bases in medicine, solution matrix, gel matrix, is also possible to cosmetics
The permitted any dosage form in field.And when preparing, compound oily preparation must be added at present in temperature lower than 66 DEG C, preferably
It is to be added at present in temperature lower than 30 DEG C.
Some specific embodiments are provided below
Embodiment 1-8 prepares prescription for Effect raw material of the present invention, as unit of g.
Embodiment 1
Weigh 0.04,20 victory peptide 0.04 of two peptide；Reactor is added in 'alpha '-hydroxy acids 1, shea butter 87.8, beeswax 10,
Stirring is warming up to 35 DEG C, and azone 0.12 is added, and 4.8 hours is kept the temperature, until being completely dissolved.
Embodiment 2
Weigh palmitoyl tripeptide 3 0.4, four victory peptides 0.2, ten victory peptides 0.2, ten SymPeptides 0.5, Argireline 0.5, two peptide 0.2；β-
Carboxylic acid 20；Reactor is added in vaseline 35, beeswax 10, white oil 30, and stirring is warming up to 80 DEG C, and trehalose 3.0, heat preservation 18 is added
Hour, until being completely dissolved.
Embodiment 3
Weigh two peptide 0.2, palmitoyl tripeptide 3 0.4, four victory peptides, 0.2,20 victory peptide 1.2, 'alpha '-hydroxy acids 10, beta-hydroxy acid 10；
Reactor is added in isopropyl palmitate 35, sad triglyceride 40, and stirring is warming up to 35 DEG C, and potassium hydroxide 3.0, heat preservation 26 is added
Hour, until being completely dissolved.
Embodiment 4
Weigh palmitoyl tripeptide 3 0.4, four victory peptides 1.6, 'alpha '-hydroxy acids 8, beta-hydroxy acid 12,144935, vaseline 10, White Mineral Oil 30
Reactor is added, stirring is warming up to 80 DEG C, and potassium hydroxide 3.0 is added, and 30 hours is kept the temperature, until being completely dissolved.
Confirmatory experiment:
Embodiment 5
Test crowd uses twice daily, once in the morning and once at night, only uses in left half of face, right one side of something face uses market sale
Vitamin A treat acne drug.Using 7 days, the corresponding half of face in left and right.
Testing result:
| Test crowd | Clearly crowd | Obvious crowd | Unobvious crowd |
| Stoste | 7 | 11 | 2 |
Test result shows that prescription of the invention has good result to treatment acne in a short time.
Embodiment 6
Cosmetics prepared by embodiment 1-4 prevent and treat acne measure of merit: selecting the aspiration that health is normal
500 people of subject, men and women is fifty-fifty, and the age from 12.5 years old to 13.5 years old, does not enter hebetic volunteers also.
Test crowd uses twice daily, and once in the morning and once at night, control group is the cosmetics without oligopeptides carboxylic acid.Adhere to making
With 2~3 years.
It is applicable in the cosmetics crowd of the carboxylic acid containing oligopeptides, whelk does not all occur.And the whelk for compareing crowd occurs
Rate is up to 93%.After there is whelk, use the cosmetics of the carboxylic acid containing oligopeptides instead, cure rate reach 100% and recurrence rate be 0.
The experimental results showed that cosmetics prepared by the present invention have the effect of preventing and treating acne well.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring substantive content of the invention.
Claims (10)
1. a kind of preparation method of the compound oily preparation prevent and treat with acne, it is characterised in that:
After dissolving carboxylic acid, oligopeptides and solvent, it is heated to 30-85 DEG C, coupling agent is added and is uniformly mixed, insulation reaction 1.5-48
Hour, until being completely dissolved；
The oligopeptides, carboxylic acid, solvent, the weight ratio between coupling agent are 0.08-2:1-20:75-98.8:0.12-3；It is described
Oligopeptides bond number containing peptide is 2-20.
2. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as described in claim 1
Be: the solvent is white oil, synthesizes saualane, saturated straight chain hydro carbons is come out from the sub-arguments such as petroleum or coal and be greater than 6 carbon and satisfy
Cycloalkane, synthesis saualanes, synthesis are saturated with cycloalkane and the saturated straight chain hydro carbons by adding hydrogen to obtain and greater than 6 carbon
Polyisobutene, synthesizing hydrogenated poly decene, the solid or liquid of hydrogenated polyolefins；It or is the saturated straight chain hydro carbons of plant origin and big
In 6 carbon saturation cycloalkane and the saturated straight chain hydro carbons by adding hydrogen to obtain and it is greater than 6 carbon saturation cycloalkane, accumulated angle
Shark alkane, synthesizing polyisobutylene, synthesizing hydrogenated poly decene, the solid or liquid of hydrogenated polyolefins；Or the monoesters for total carbon number greater than 8
The solid or liquid of class compound, ether compound；Or the solid or liquid of the silicon-containing compound for total carbon number greater than 8；Or it is
The solid or liquid of total more ester type compounds of the carbon number greater than 20；It or is above-mentioned several mixture.
3. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as claimed in claim 2
Be: the viscosity of the solvent is 10-20000cps.
4. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as described in claim 1
Be: the hydroxyl of the carboxylic acid is in the position α and β of carboxylic acid.
5. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as claimed in claim 4
Be: the molecular weight of the carboxylic acid is less than 2000.
6. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as described in claim 1
Be: the coupling agent is the mixture of one or more of neutralizer, solubilizer, transdermal agent, antioxidant, preservative.
7. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as described in claim 1
Be: the temperature of the heating is 32-66 DEG C.
8. having effects that prevent and treat the preparation method of the compound oily preparation of acne, feature as described in claim 1
Be: the reaction when it is 1.55-40 hours a length of.
9. a kind of have effects that prevent and treat the compound oily preparation of acne, it is characterised in that: appointed using such as claim 1-8
Have effects that the preparation method for preventing and treating the compound oily preparation of acne is prepared described in one.
10. a kind of application of the compound oily preparation prevent and treat with acne, it is characterised in that: will be such as claim
Have effects that the compound oily preparation for preventing and treating acne is used to prepare cosmetics described in 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910165267.9A CN109662903A (en) | 2019-03-05 | 2019-03-05 | Have effects that prevent and treat the compound oily preparation and the preparation method and application thereof of acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910165267.9A CN109662903A (en) | 2019-03-05 | 2019-03-05 | Have effects that prevent and treat the compound oily preparation and the preparation method and application thereof of acne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109662903A true CN109662903A (en) | 2019-04-23 |
Family
ID=66152211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910165267.9A Pending CN109662903A (en) | 2019-03-05 | 2019-03-05 | Have effects that prevent and treat the compound oily preparation and the preparation method and application thereof of acne |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109662903A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655223A (en) * | 2013-11-14 | 2014-03-26 | 陕西东大生化科技有限责任公司 | Preparation with effects of preventing and treating acnes and application thereof |
| CN103655224A (en) * | 2013-11-14 | 2014-03-26 | 陕西东大生化科技有限责任公司 | Preparation with function of preventing and treating sensitivity or allergy and application thereof |
-
2019
- 2019-03-05 CN CN201910165267.9A patent/CN109662903A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655223A (en) * | 2013-11-14 | 2014-03-26 | 陕西东大生化科技有限责任公司 | Preparation with effects of preventing and treating acnes and application thereof |
| CN103655224A (en) * | 2013-11-14 | 2014-03-26 | 陕西东大生化科技有限责任公司 | Preparation with function of preventing and treating sensitivity or allergy and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘庆东等: ""寻常性痤疮局部药物治疗进展"", 《中国麻风皮肤病杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4889093B2 (en) | Sponge-based therapeutic compositions for the treatment and prevention of skin diseases | |
| JP4564471B2 (en) | Composition suitable for external use | |
| JP2010132629A (en) | External composition for skin | |
| JP2022532872A (en) | Compositions and methods for improving subcutaneous bleeding and rejuvenating the skin | |
| KR102071627B1 (en) | Peeling gel composition for removing keratin of skin and manufacturing method thereof | |
| CN111743830A (en) | Acne-removing composition and application thereof | |
| CN103655223B (en) | A kind of preparation with prevention and treatment acne effect and application thereof | |
| KR20090038648A (en) | A composition using the cosmetic containing chamaecyparis obtusa oil for a pimpled skin | |
| CN108056931A (en) | A kind of acne eliminating cream and preparation method thereof | |
| TW201416071A (en) | Antiseptic, antiseborrheic and exfoliating composition to remove or prevent acne | |
| EP1365781B1 (en) | Acrochordon alleviation | |
| CN115429738B (en) | Acne-removing, repairing and reviving essence and preparation method thereof | |
| CN109662903A (en) | Have effects that prevent and treat the compound oily preparation and the preparation method and application thereof of acne | |
| WO2016144196A1 (en) | A pharmaceutical and/or cosmetic composition for treating skin diseases and damages, the process for preparing of the pharmaceutical and/or cosmetic composition and its use | |
| CN109394648A (en) | A kind of salubrious anti-acne repairs creams and its manufacture craft | |
| JP6001840B2 (en) | Drugs for living tissue | |
| CN109674684A (en) | Have effects that prevent and treat the compound formulation and the preparation method and application thereof of acne | |
| KR102293585B1 (en) | Wax-type cleanser | |
| US3670084A (en) | Method of treating psoriasis with cycloheximide | |
| CN109674690A (en) | Have effects that treat the repellent antipruritic Unctuous compositions and the preparation method and application thereof of bite by mosquitos | |
| WO2009020398A2 (en) | Skin care product | |
| KR102038366B1 (en) | Cosmetic composition for improving acne skin | |
| KR102329748B1 (en) | Wax-type cleanser improving problematic skin | |
| KR101128477B1 (en) | Cosmetic Composition for Acne Improvement and Method for Preparing Therof | |
| US10765708B2 (en) | Formulation and treatment for acne |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 518000, room five, floor 192, 501 Chongqing Road, Heping community, Fuyong street, Baoan District, Guangdong, Shenzhen Applicant after: Shenzhen Xiandi Cosmetics Co., Ltd Address before: 518000, room five, floor 192, 501 Chongqing Road, Heping community, Fuyong street, Baoan District, Guangdong, Shenzhen Applicant before: SHENZHEN SANDA COSMETICS Co.,Ltd. |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190423 |
|
| RJ01 | Rejection of invention patent application after publication |