CN109619566A - A kind of nutraceutical for alleviating asthenopia - Google Patents

A kind of nutraceutical for alleviating asthenopia Download PDF

Info

Publication number
CN109619566A
CN109619566A CN201910058220.2A CN201910058220A CN109619566A CN 109619566 A CN109619566 A CN 109619566A CN 201910058220 A CN201910058220 A CN 201910058220A CN 109619566 A CN109619566 A CN 109619566A
Authority
CN
China
Prior art keywords
parts
food
ight
daily
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910058220.2A
Other languages
Chinese (zh)
Inventor
吴贤道
苏兆浪
廖小文
许旖旎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Wei Wei Food Technology Co Ltd
Original Assignee
Guangzhou Wei Wei Food Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Wei Wei Food Technology Co Ltd filed Critical Guangzhou Wei Wei Food Technology Co Ltd
Priority to CN201910058220.2A priority Critical patent/CN109619566A/en
Publication of CN109619566A publication Critical patent/CN109619566A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/01—Instant products; Powders; Flakes; Granules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention discloses a kind of prescription nutrition foods of sight protection, this health food is by daily food and ight food composition, daily raw-food material includes lutein ester, zeaxanthin, beta carotene, blueberry powder, tealeaves theanine, ginseng, premix part composition, ight food includes lutein ester, zeaxanthin, beta carotene, blueberry powder, semen ziziphi spinosae, γ-aminobutyric acid, premix part composition, this nutraceutical by daily food and ight food at times slow down asthenopia, the nutraceutical is presented as health food, candy, beverage, solid beverage etc..

Description

A kind of nutraceutical for alleviating asthenopia
Technical field
The present invention relates to field of health care food, and in particular to a kind of nutraceutical for alleviating asthenopia.
Background technique
Visual fatigue is also known as asthenopia, is eye or whole body apparatus factors and spirit based on the subjective symptoms of patient's eye The syndrome that (psychology) factor is interweaved.The symptom of visual fatigue has dry and astringent eye, foreign body sensation, eyelid sense of heaviness, blurred vision, fear Light stream tear, eye distending pain etc., serious person is it may also occur that katzeniammer, apathetic, absent minded, decrease of memory, appetite The whole bodies syndromes such as depressed and neck aching pain in waist and back, teenager is it may also occur that myopia or the original myopic degree of intensification etc..
In communication society, the video display terminal (vdt)s such as computer, television set have been deep into daily life, have occurred therewith A series of problems, such as visual fatigue, is more and more.The high incidence age of studies have shown that visual fatigue is 21-50 years old, the people of this age bracket Group's big, work strain with eye intensity, makes eyes be chronically at adjusting Set Status, is easy to produce fatigue.Constantly prolonged between at the moment Long, intensity increases, and often operates computer or works before fluorescent screen for a long time, it has also become visual fatigue key factor shy with strangers at present. In addition, the disease incidence of the elderly's eye disease also increases year by year.According to investigations, age-related eye macula lutea moves back damage denaturation (AMD) It has been more than the eye disease such as glaucoma, detachment of retina, has become the first cause of the elderly's visual impairment and blindness, in 50 years old or more people In group, the disease disease incidence about 15.5%, wherein there is 5.1% blinding.In addition, facing the student of heavy schoolwork burden, it is accustomed to eye The unhealthy appearance for also resulting in the visual problems such as asthenopia, visual problems have become the No.1 barrier of middle and primary schools' health at present Hinder.Modern medicine study shows the generation of vitamin and eye illness, the quality of eyesight has very close relationship.It is excessive with eye Person, vitamin needed for needing more eyes and minerals.Nutrient needed for reasonable supplement eyes to protection eyes, is prevented Only eyesight injury, prevention and treatment eye illness, raising eyesight are extremely important.Although visual fatigue etc. can be alleviated there is also some currently on the market The nutriment of visual problems, but its improvement is not comprehensive, how is unable to comprehensively solve eye problems, therefore effect is unobvious It is that the application is dedicated to solving the problems, such as while present people that visual problems, which can preferably be alleviated, more fully improve vision health Often stay up late, it cannot be guaranteed that sufficient sleep, the time for allowing eyes to rest it is very of short duration.
Existing vision protecting foodstuff on the market alleviates hypopsia merely by supplement neccessary composition, does not account for Different health-care effects is needed to the different periods.Therefore a kind of vision protecting foodstuff for different periods is designed, it appears outstanding It is important.
Summary of the invention
The purpose of the present invention is to provide a kind of prescription nutrition food of sight protection, this health care product passes through daily food With ight food at times slow down hypopsia, in order to reach said effect, concrete scheme of the invention is as follows:
A kind of prescription nutrition food of sight protection, the prescription nutrition food of sight protection is by daily food and ight food Composition, daily food precentagewise are made of 30%-70% raw material 30%-70% auxiliary material, and daily raw-food material is in parts by weight Including 0.05 part -20 parts of lutein ester, 0.05 part -10 parts of zeaxanthin, 0.02 part -10 parts of beta carotene, 40 parts of blueberry powder - 94.88 parts, 0.5 part -2 parts of tealeaves theanine, 5 parts of 7-10 parts of ginseng, premix -20 parts of compositions, ight food press percentage Than being made of 30%-70% raw material and 30%-70% auxiliary material, ight raw-food material includes lutein ester 0.05 in parts by weight Part -20 parts, 0.05 part -10 parts of zeaxanthin, 0.02 part -10 parts of beta carotene, 40 parts -94.88 parts of blueberry powder, semen ziziphi spinosae 2 Parts -10 parts, 5 parts of 0.5 part -0.8 part of γ-aminobutyric acid, premix -20 parts of compositions, auxiliary material by milk powder, PURE WHEY, Lecithin, medium chain triglyceride, oligofructose, oligoisomaltose, polydextrose, white granulated sugar, edible glucose, resistance paste Essence, tealeaves theanine, γ-aminobutyric acid, lutein, citric acid, sodium citrate, microcrystalline cellulose, magnesium stearate, carboxylic propyl first 3 kinds or 3 kinds base sodium cellulosate, Sucralose, steviol glycoside, sodium benzoate, potassium sorbate, edible essence composition described above.
Preferably, daily raw-food material includes 10 parts of lutein ester, 4 parts of zeaxanthin, beta carotene 6 in parts by weight Part, 75 parts of blueberry powder, 1 part of tealeaves theanine, 8 parts of ginseng, 8 parts of premix compositions, ight raw-food material is in parts by weight Including 10 parts of lutein ester, 5 parts of zeaxanthin, 6 parts of beta carotene, 70 parts of blueberry powder, 8 parts of semen ziziphi spinosae, γ-aminobutyric acid 0.7 part, 15 parts of premix compositions.
Preferably, daily food precentagewise is made of 60% raw material and 40% auxiliary material, ight food precentagewise by 60% raw material and 40% auxiliary material composition.
Preferably, which is characterized in that auxiliary material includes 15 parts of milk powder, 10 parts of oligofructose, carboxylic hydroxypropyl methyl in parts by weight 8 parts of sodium cellulosate, 10 parts of sodium benzoate.
Preferably, a kind of preparation method of such as prescription nutrition food of a kind of sight protection of claim 1-4, feature It is, comprising the following steps: (1) crush: raw material is crushed respectively；(2) mixing: by weight mixing raw material, obtains mixed Close powder A；By mixed powder A and the total mixed powder of auxiliary material；(3) softwood processed: total mixed powder is mixed with ethyl alcohol, obtains mixing softwood；(4) it makes Grain: softwood is sieved and is pelletized, wet granular is obtained；(5) dry: wet granular being dried, the formula nutritional food of sight protection is obtained Product.
Zeaxanthin: (3R, 3'R)-dihydroxy-beta carotene, also known as luteole, molecular formula C40H56O2, molecule Amount is 566.88, belongs to isoprenoid, is a kind of oxygen containing carotenoid (Xanthophyll), with lutein (lutein) belong to isomer.The luteole being mostly present in nature is all trans isomer (AllE-iso- mer).In human body, zeaxanthin is mainly distributed in the histoorgans such as eye, liver, pancreas, kidney, spleen, ovary, to strong Health plays an important role, and in eyes, zeaxanthin is concentrated mainly on the macula lutea district center of retina, and human body and animal can not be certainly Body synthesizes zeaxanthin, it is necessary to be obtained by food or replenishers.
Lutein ester: lutein ester is a kind of important carotenoid aliphatic ester, character: reddish brown tiny Grain.Primary structure is connected by two six-membered carbon rings by the long-chain of the conjugated double bond of a son Han ten eight carbon atoms, molecular weight: 1045.71 molecular formula: an important biological function of C72H116O4, lutein are exactly to protect retina, prevent with it is ultraviolet The damage of the close blue light of line wavelength.Senile macular degeneration (mono- relatedMacularDegenera- of Age of whole world discovery Tion, AMD) be over-65s crowd main diseases causing blindness, after natural carotenol ester and luteole ester are shot in human body, Under the action of body fat enzyme, it is hydrolyzed into the lutein and luteole of free state.They are deposited on human eye bottom Huang with high concentration In spot, the absorbent of near ultraviolet blue light can be used as, by capture free radical, prevent or reduce oxidation and free radical to retina band Come injury and exercise defencive function, the incidence of AMD can be effectively reduced.
Beta carotene, β-carrotene (C40H56) are one of carotenoid and the fat-soluble chemical combination of crocus Object, it is also most stable of natural pigment that it, which is most generally existing in nature,.In many natural foods for example: green vegetables, sweet Potato, carrot, spinach, pawpaw, mango etc. all have β-carrotene abundant.β-carrotene is a kind of antioxidant, It is the maintenance indispensable nutrient of human health with detoxication, in anticancer, prevention cardiovascular disease, cataract and resists There is significant function in oxidation, and prevents a variety of degenerative disorders caused by aging and aging in turn.Carrotene nearly ten years The concern unprecedented by medical field, the reason is that the investigation explanation of many epidemiology: often absorbing abundant carrot in diet The crowd of element, the chance for suffering from the diseases such as artery sclerosis, certain cancerous swellings and degeneration eye illness are all significantly lower than the less Hu trailing plants of intake The crowd of Bu Su, many zooperies also demonstrate this viewpoint.Such as: the eyesight of eyes depends on the macula lutea on eyeground, if Do not have enough β-carrots usually go bail for shield and support, retrograde lesion, that is, aging will occur for this position , eyesight, which can fail, even finally occurs yctalopia.This disease is mainly in the elderly, although medical field it is thought that aging one Kind performance, but point out that this degeneration eye illness can usually prevent by absorbing enough β-carrots simultaneously.This Great discovery allows people to be known as new understanding to carrot, it is believed that it is not only to realize balanced nutritious necessary substance, together When additionally aid people and prevent disease, promote longevity, promote physical fitness and quality of life.
Blueberry powder, nutritional ingredient rich in Blueberry, have prevent cranial nerve aging, protection eyesight, heart tonifying, Anticancer, the functions such as enhances the immune of the body at softening blood vessel, and nutritional ingredient is high.Wherein, since blueberry is rich in anthocyanidin, have and live Change retina effect, eyesight can be strengthened, prevents eyeball fatigue and gazed at.And the five of the World Food Programme's recommendation are big strong One of Kang Shuiguo.And it is studied according to the U.S., Japan, European Section scholar, often edible blueberry product, can also significantly enhance view Power, anti-eye strain.Clinical medicine report is also shown, and the anthocyanidin in blueberry can promote the visual purple in retina cell Regeneration, pre- myopia prevention promote eyesight.
Tealeaves theanine, it is distinctive free amino acid that theanine is the discovery that earliest to be extracted from natural plants tealeaves, Theanine is glutamic acid gamma-buserelin, pleasantly sweet.Theanine content in tealeaves is changed because of the kind of tea, position.Tea ammonia Acid accounts for the 1%-2% of weight in dry tea.Theanine is similar to intracerebral active material glutamine, glutamic acid on chemical constitution, It is the main ingredient for promoting the production of body fluid in tealeaves and moistening sweet tea.Theanine content is about 1~2% of newly picked and processed tea leaves or so, in stem tea content with Time course is reduced.The active amino acid of theanine is L-thiamine, the amino acid being naturally occurring in green tea.Tealeaves theanine Different with general sedative, it is a kind of relaxant that it, which is a kind of amino acid of unique free form, and mood is promoted to loosen Simultaneously without leading to sleepy or other side effects.Pass through the effect loosened and its anti-aging function, tealeaves theanine It can safeguard the health of cardiovascular function, theanine can be obviously promoted mesencephalic centre dopamine D_2 receptors, improve intracerebral dopamine physiology Activity.Dopamine is a kind of central neurotransmitter for activating cranial nerve cell, the close phase of emotion state of physiological activity and people It closes.Help to mitigate operating pressure, mitigates the symptom of fatigue.
γ-aminobutyric acid, English name: γ-aminobutyricacid (GABA) γ-aminobutyric acid, chemical name: 4- Aminobutyric acid, alias: γ-aminobutyric acid, amino acid injection-800, nipecotic acid.Molecular formula: C4H9NO2.Molecular weight: 103.1.It is widely distributed In in animal and plant body.All contain GABA in plant such as Macroptilium, ginseng category, the seed of Chinese herbal medicine, rhizome and tissue fluid.In animal body Interior, GABA is almost existed only in nerve fiber, and the content in mesencephalic tissue is about 0.1-0.6mg/ grams of tissue, immunology Studies have shown that the highest region of its concentration is black substance in brain.GABA is the important inhibition of the more deep one kind of current research Nerve mediator, it participates in a variety of metabolic activities, has very high physiological activity.Gamma amino butyric acid is in central nervous system Critically important inhibitory neurotransmitter, it is a kind of naturally occurring non-protein composition amino acid, has extremely important physiology Function, it can promote the reactivity of brain, brain tonic and intelligence development, and anti-epileptic promotes sleep, and beauty moisturizing delays brain aging function, can mend Human body inhibitory neurotransmitter is filled, there is good blood pressure reduction effect.Promote kidney Fitness improvement and protective effect.Inhibit fatty liver And obesity, activate liver function.The micro gamma aminobutanoic acid of daily iron supplement is conducive to the alleviation of heart and brain blood pressure, and can promote people The balance of vivo acid metabolism, adjusts immune function.
Semen ziziphi spinosae, Chinese medicine name.This product is the seed of rhamnaceae plant wild jujube.It harvests when the fruit matures in the fall, by fruit It impregnates one night, pulp is removed in stranding, pulls out, pulverizes fruit stone with stone, takes out seed, dry.Major function are as follows: nourishing the liver, calming heart, peace Mind, arrest sweating.Restlessness of asrhenia type and insomnia is controlled, palpitation of palpitating with fear, polydipsia, abnormal sweating.Semen ziziphi spinosae decoction is oral to big white mouse or intraperitoneal injection shows Calm and somnolence, no matter daytime or night, normal condition or coffee, the excitatory state because caused by, semen ziziphi spinosae can show above-mentioned Effect, calm index when small white mouse is oral are 1.95, show and act synergistically with barbiturate, semen ziziphi spinosae continuous application 6 It, can make animal sleep shoal, decreased duration, i.e. generation tolerance, but can disappear after being discontinued 1 week.Oral semen ziziphi spinosae can Make the significant reduction of defensive type motion conditioned reflex number, interior inhibition diffusion, conditioned reflex is subsided, and inhibits cat as caused by morphine Manic phenomenon.
Ginseng, the ginsenoside in ginseng have the function of improving brain oxygen uptake capacity antifatigue.
The utility model has the advantages that
The prescription nutrition food of sight protection of the present invention is made of daily-use health-care food and ight health food, wherein daily All guarantee health care of the present invention to eyesight in health food and ight health food containing zeaxanthin, lutein ester, blueberry powder Effect, is then added to tealeaves theanine and ginseng in daily-use health-care food, tealeaves theanine and ginseng play raising intracerebral Dopamine physiological activity mitigates operating pressure, mitigates the symptom effect of fatigue, the work on daytime is improved while protecting eyesight Efficiency guarantees the vigor on daytime, reduces tired eye, is added to γ-aminobutyric acid and semen ziziphi spinosae in ight health food, and γ-aminobutyric acid and the calm effect calmed the nerves of semen ziziphi spinosae, improve sleep quality, and repair in sleep to eyesight, daily The problem of health food and the cooperation of ight health food fundamentally handle the blurring of image.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Daily food formula see the table below 1 in the embodiment of the present invention 1~3 and comparative example 1~2
Table 1
Ight food formula see the table below 2 in the embodiment of the present invention 1~3 and comparative example 1~2
Table 2
Raw material accounts for 50% in embodiment 1, and auxiliary material accounts for 50%, and raw material accounts for 30% in embodiment 2, and auxiliary material accounts for 70%, embodiment 3 Middle raw material accounts for 70% auxiliary material and accounts for 30%.
The preparation method of embodiment 1-3 and comparative example 1-2, comprising the following steps: (1) crush: raw material is subjected to powder respectively It is broken；(2) mixing: by weight mixing raw material, obtains mixed powder A；By mixed powder A and the total mixed powder of auxiliary material；(3) softwood processed: will Total mixed powder is mixed with ethyl alcohol, obtains mixing softwood；(4) it pelletizes: softwood being sieved and is pelletized, wet granular is obtained；(5) dry: by wet Grain is dried, and obtains the prescription nutrition food of sight protection.
The difference of comparative example 3 and embodiment 3 is only that daily food does not add tealeaves theanine, and ight food does not add Add γ-aminobutyric acid.
The difference of comparative example 4 and embodiment 3 is only that daily food does not add ginseng, and ight food does not add wild jujube Benevolence.
Comparative example 5 is certain commercially available vision protecting foodstuff.
1, acute toxicity testing:
Experimental method: SD rat (weight 180g~220g) 20, half male and half female.It is quasi- if mono- dosage group of 15g/kg.bw Tested material 75g really is weighed, is formulated into 200ml with distilled water, by 2ml/100g.bw oral stomach-filling twice, interval time is 4 small When, dead animal number after two weeks and general health situation are observed after stomach-filling, and tested material acute toxicity is judged according to maximal tolerance dose. The tested material is the health care product that embodiment 1 provides.
Experimental result
3. the acute toxicity tests of table
Gender Size of animal Dosage g/kg.bw Dead animal number/only MTD(g/kg.bw) Conclusion
It is male 10 15 0 > 15 It is nontoxic
It is female 10 15 0 > 15 It is nontoxic
After oral contamination, animal dead is had no in two weeks, also without apparent poisoning symptom or adverse reaction, the results are shown in Table 1. It cuts open after the test within two weeks and kills all animals, internal organs show no obvious abnormalities variation.I.e. this inspection product are to female, male SD rat Acute oral MTD is greater than 15g/kg.bw, belongs to non-toxic type.Its experimental result of health care product and reality that other embodiments of the invention provide It is identical to apply example 1.
2,30 days feeding trial ablactation SD rat adaptable feds of rat were randomly divided into four groups, every group 20 by weight after 1 week Only, half male and half female.Test sets a negative control group (distilled water) and three tested material dosage groups: 1.5g, 3.5g and 5.0g/ Kg.bw (is equivalent to 30,70 and 100 times of human body recommended intake.Preparation method: 15g, 35g and 50g sample are weighed respectively, respectively Add distilled water to 100ml).Tested material is the health care product that embodiment 1 provides.It is primary that animal presses 1ml/100g.bw stomach-filling daily, even It is 30 days continuous.Claim a weight of animals weekly, twice to appetite and surplus appetite, and calculates food ration.It is taken the photograph respectively by Zhou Zengchong and week Appetite calculates all food utilizations (%), while calculating total food utilization rate (%).Put to death animal after 30 days, carry out hematology, Serum bichemisbry and histopathology and organ coefficient measurement.Negative control group and 3 dosage group animals during 30 days feed, Ingest, drink water, stool and urine it is normal, growth and development situation and general performance are good, do not observe that evident act changes and poisoning table It is existing.
Human feeding trial is carried out to the health care product that 1-3 of the embodiment of the present invention and comparative example 1-4 are obtained.
Tested crowd: selecting the age by the principle of voluntariness is 18~65 years old, eyesight fatiguability person.Subject Exclusion Criteria: suffer from Infectious, traumatic eye part disease person；With eye disease patient inside and outside cornea, crystal, vitreum, eyeground pathological changes etc.；With the heart The diseases patient such as blood vessel, the cerebrovascular, liver, kidney, hemopoietic system；Article related with tested function is taken in a short time, is influenced to knot The judgement person of fruit；It takes other for a long time and fails terminator in relation to therapeutic agent, health care product or using other treatment methods；It does not meet It is included in standard, not by regulation is edible or the not congruent influence effect of data or safety judgement person.
Experimental design and grouping: 480 subjects are randomly divided into embodiment 1-3 and 8 groups of comparative example 1-5, every group of 60 people, The factors such as age, gender, eyesight are comparable, and test result is used and compareed between itself cross-reference and group.Embodiment 1-3 and Early 10 points of comparative example 1-4 subject are taken corresponding daily protection food, and 10 points of evening takes corresponding ight protection food, comparison 5 subject of example is early, 10 points of evening respectively takes an analysis of functional food sold.
Eyesight improving effect see the table below 4
By table 4,1-3 of the embodiment of the present invention has the effect of improving eyesight well, while using the test of embodiment 1-3 Person indicates that taking rear sleep quality improves, daily abundant as possible.The above embodiments are merely illustrative of the technical solutions of the present invention and It is unrestricted, although being described the invention in detail referring to preferred embodiment, those skilled in the art should understand that, It can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the objective and model of technical solution of the present invention It encloses, is intended to be within the scope of the claims of the invention.Technology not described in detail in the present invention, shape, construction portion It is well-known technique.

Claims (7)

1. a kind of prescription nutrition food of sight protection, which is characterized in that the prescription nutrition food of the sight protection is by daily Food and ight food composition, the daily food precentagewise are made of 30%-70% raw material and 30%-70% auxiliary material, institute Stating daily raw-food material in parts by weight includes 0.05 part -20 parts of lutein ester, 0.05 part -10 parts of zeaxanthin, β-carrot Plain 0.02 part -10 parts, 40 parts -94.88 parts of blueberry powder, 0.5 part -2 parts of tealeaves theanine, 7-10 parts of ginseng, premix 5 - 20 parts of compositions of part, the ight food precentagewise are made of 30%-70% raw material and 30%-70% auxiliary material, the ight food Product raw material includes 0.05 part -20 parts of lutein ester, 0.05 part -10 parts of zeaxanthin, 0.02 part of beta carotene-in parts by weight 10 parts, 40 parts -94.88 parts of blueberry powder, 2 parts -10 parts of semen ziziphi spinosae, 0.5 part -0.8 part of γ-aminobutyric acid, 5 parts of premix - 20 parts of compositions.
2. auxiliary material as described in claim 1 is by milk powder, PURE WHEY, lecithin, medium chain triglyceride, oligofructose, oligomeric Isomaltose, polydextrose, white granulated sugar, edible glucose, resistant dextrin, tealeaves theanine, γ-aminobutyric acid, lutein, lemon Lemon acid, sodium citrate, microcrystalline cellulose, magnesium stearate, carboxylic propyl methocel sodium, Sucralose, steviol glycoside, benzoic acid 3 kinds or 3 kinds sodium, potassium sorbate, edible essence composition described above.
3. a kind of prescription nutrition food of sight protection as described in claim 1, which is characterized in that the daily raw-food material It in parts by weight include 10 parts of lutein ester, 4 parts of zeaxanthin, 6 parts of beta carotene, 75 parts of blueberry powder, tealeaves theanine 1 Part, 8 parts of ginseng, 8 parts of premix compositions, the ight raw-food material includes 10 parts of lutein ester, corn in parts by weight 15 parts of 5 parts of yellow matter, 6 parts of beta carotene, 70 parts of blueberry powder, 8 parts of semen ziziphi spinosae, 0.7 part of γ-aminobutyric acid, premix groups At.
4. a kind of prescription nutrition food of sight protection as described in claim 1, which is characterized in that the daily food presses hundred Ratio is divided to be made of 60% raw material and 40% auxiliary material, the ight food precentagewise is made of 60% raw material and 40% auxiliary material.
5. a kind of prescription nutrition food of sight protection as described in claim 1, which is characterized in that the auxiliary material includes cream Powder, oligofructose, carboxylic propyl methocel sodium, sodium benzoate, the milk powder, oligofructose, carboxylic propyl methocel sodium, The mass ratio of sodium benzoate is 60:30:5:5.
6. a kind of prescription nutrition food of sight protection as described in claim 1, which is characterized in that the premix by VitAVitE, vitamin C, vitamin B1, zinc gluconate and taurine compound, VitAVitE, Vitamin C, vitamin B1, zinc gluconate and taurine quality be 1:1:1:1:1:1.
7. a kind of a kind of preparation method of the prescription nutrition food of sight protection as described in claim 1-6, which is characterized in that The following steps are included: (1) crushes: raw material is crushed respectively；(2) mixing: by weight mixing raw material, obtains mixed powder A； By mixed powder A and the total mixed powder of auxiliary material；(3) softwood processed: total mixed powder is mixed with ethyl alcohol, obtains mixing softwood；(4) it pelletizes: will Softwood sieving granulation, obtains wet granular；(5) dry: wet granular being dried, the prescription nutrition food of sight protection is obtained.
CN201910058220.2A 2019-01-22 2019-01-22 A kind of nutraceutical for alleviating asthenopia Pending CN109619566A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910058220.2A CN109619566A (en) 2019-01-22 2019-01-22 A kind of nutraceutical for alleviating asthenopia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910058220.2A CN109619566A (en) 2019-01-22 2019-01-22 A kind of nutraceutical for alleviating asthenopia

Publications (1)

Publication Number Publication Date
CN109619566A true CN109619566A (en) 2019-04-16

Family

ID=66063013

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910058220.2A Pending CN109619566A (en) 2019-01-22 2019-01-22 A kind of nutraceutical for alleviating asthenopia

Country Status (1)

Country Link
CN (1) CN109619566A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110521842A (en) * 2019-05-06 2019-12-03 高思 Human lens and retinal photoreceptor cells nutrition eye-candy improving eyesight herbal medicine candy in white
CN111227097A (en) * 2020-02-27 2020-06-05 山东祥宏堂医药有限公司 Blueberry lutein ester candy tablet and preparation method thereof
CN111227154A (en) * 2019-12-31 2020-06-05 许昌神飞航天生物科技有限公司 Aerospace-grade nutritional solid beverage for regulating eyesight
CN112655971A (en) * 2020-12-21 2021-04-16 康洛信(广东)生物科技有限公司 Collagen peptide composition for relieving eye dryness and fatigue and preparation method thereof
CN115316664A (en) * 2022-04-25 2022-11-11 山西振东五和医养堂股份有限公司 Blueberry lutein ester with eyesight protection effect and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101731350A (en) * 2009-12-24 2010-06-16 内蒙古蒙牛阿拉乳制品有限责任公司 Day and night separated infant milk powder
CN103202511A (en) * 2013-03-20 2013-07-17 吉林敖东集团长白庄参茸有限公司 Ginseng blueberry cassia-seed solid drink
CN105901577A (en) * 2016-04-15 2016-08-31 胥永贵 Nutritional agent for reinforcing brain, protecting eye and strengthening body and preparation method and application thereof
CN108324705A (en) * 2018-02-12 2018-07-27 成都图径生物科技有限公司 Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and anthocyanidin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101731350A (en) * 2009-12-24 2010-06-16 内蒙古蒙牛阿拉乳制品有限责任公司 Day and night separated infant milk powder
CN103202511A (en) * 2013-03-20 2013-07-17 吉林敖东集团长白庄参茸有限公司 Ginseng blueberry cassia-seed solid drink
CN105901577A (en) * 2016-04-15 2016-08-31 胥永贵 Nutritional agent for reinforcing brain, protecting eye and strengthening body and preparation method and application thereof
CN108324705A (en) * 2018-02-12 2018-07-27 成都图径生物科技有限公司 Composition for relieving asthenopia containing theanine, γ-aminobutyric acid and anthocyanidin

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110521842A (en) * 2019-05-06 2019-12-03 高思 Human lens and retinal photoreceptor cells nutrition eye-candy improving eyesight herbal medicine candy in white
CN111227154A (en) * 2019-12-31 2020-06-05 许昌神飞航天生物科技有限公司 Aerospace-grade nutritional solid beverage for regulating eyesight
CN111227097A (en) * 2020-02-27 2020-06-05 山东祥宏堂医药有限公司 Blueberry lutein ester candy tablet and preparation method thereof
CN112655971A (en) * 2020-12-21 2021-04-16 康洛信(广东)生物科技有限公司 Collagen peptide composition for relieving eye dryness and fatigue and preparation method thereof
CN115316664A (en) * 2022-04-25 2022-11-11 山西振东五和医养堂股份有限公司 Blueberry lutein ester with eyesight protection effect and preparation method thereof

Similar Documents

Publication Publication Date Title
CN109619566A (en) A kind of nutraceutical for alleviating asthenopia
EP2138055B2 (en) Formula food to be beneficial for visuognosis persistence and use thereof
CN104739921B (en) A kind of prescription lozenge and preparation method thereof for alleviating visual fatigue
JP2021008447A (en) Health keeping product composition applicable to adult female, elderly, and sub-healthy people
CN108157568A (en) A kind of Combined candy for alleviating visual fatigue and its preparation method and application
CN102742656B (en) Milky tea relieving asthenopia and preparation method thereof
CN104839688A (en) Eye care preparation and preparation method thereof
CN104474018A (en) Health-care soft capsule for relieving asthenopia
CN108041609B (en) Food composition with functions of relieving visual fatigue and preventing myopia and preparation method thereof
CN112715729A (en) Blueberry lutein ester tablet candy for relieving visual fatigue and preparation method thereof
CN106692187A (en) Composition for improving visuognosis persistence and protecting eye health
KR20140034620A (en) Composition for preventing or treating diabetbes mellitus disease containing extract of plants
CN102150860B (en) Composition for easing visual fatigue and assisting in improving memory
CN102090637A (en) Collagen-containing compound nutritious powder
CN115444134A (en) Blueberry lutein ester chewable tablet and preparation method thereof
CN104940273A (en) Vision improvement healthcare product and preparation method thereof
CN109619189A (en) A kind of black fruit Sorbus alnifloria eye protecting milk tablet of sea-buckthorn and preparation method thereof
KR100503208B1 (en) Diet-food composition
CN108338364A (en) Composition for relieving asthenopia containing theanine and astaxanthin
CN104161260A (en) Composition used for relieving asthenopia and preparation method thereof
CN101856429B (en) Medicine compound with visual fatigue relieving function and preparation method thereof
JP4669077B1 (en) Autonomic nerve regulator containing asparagus pseudo-leaf as active ingredient
CN101850028B (en) Composition with function of relieving visual fatigue
CN109123674A (en) A kind of black fruit fructus lycii compound alleviation visual fatigue piece and its preparation process
CN109674050A (en) Antifatigue food compositions and antifatigue

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20190416

RJ01 Rejection of invention patent application after publication