CN109568234B - Gel type safflower whitening mask and preparation method thereof - Google Patents
Gel type safflower whitening mask and preparation method thereof Download PDFInfo
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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Abstract
The invention discloses a gel type safflower whitening mask and a preparation method thereof, wherein the gel type safflower whitening mask comprises the following components in percentage by weight: 1-4% of rhizoma bletillae alcohol precipitation liquid, 1-4% of safflower water extract, 0.04-0.4% of whitening enhancer, 0.01-0.05% of sodium hyaluronate, 0.05-0.5% of allantoin, 3-7% of carbomer, 5-20% of glycerol, 5-20% of butanediol, 0.1-0.6% of methylparaben and the balance of deionized water. In the gel type safflower whitening mask prepared by the invention, the rhizoma bletillae alcohol precipitation liquid and the safflower water extract can effectively inhibit tyrosinase activity, can alleviate chloasma and black specks caused by acne, and have the effects of removing freckles, whitening and moisturizing; the whitening reinforcing agents, namely the sodium zinc ethylene diamine tetraacetate and the vitamin C can inhibit the activity of tyrosinase and block the generation of melanin, can improve the inhibition activity of rhizoma bletillae alcohol precipitation liquid and safflower water extract on the tyrosinase, and has a synergistic function; the chitosan and morin can remove facial Pb2+、Hg2+、Ni2+The heavy metal ions reduce the harm of skin aging and wrinkles caused by heavy metals.
Description
Technical Field
The invention relates to a traditional Chinese medicine mask and a preparation method thereof, in particular to a gel type safflower whitening mask and a preparation method thereof.
Background
With the improvement of life quality, people are more and more urgent to pursue beauty, so that the variety of cosmetics is more and more, and the facial mask is an important member of the cosmetics. At present, the facial masks are various in types, and are classified into a patch facial mask, a tear facial mask, a gel facial mask and the like. The gel type mask is a gel paste which is easy to be uniformly applied on the face, can block the contact of the skin of the face and the air, effectively prevents the evaporation of water, increases the humidity of the horny layer and softens the horny layer; can also dilate pores on the surface of the skin, and is beneficial to the absorption of nutrient components.
With the development of modernization of traditional Chinese medicines, more and more traditional Chinese medicines are found to have the effect of beautifying and are applied to skin care products. The rhizoma Bletillae is dried tuber of Bletillae Bletilla striata (Thunb.) Reichb.f. of Orchidaceae. Has the effects of astringing to stop bleeding, reducing swelling and promoting granulation, and is commonly used for symptoms such as hemoptysis, hematemesis, traumatic hemorrhage, sore and carbuncle, pyogenic infections, skin rhagadia and the like, so the skin care product with the effects of stopping bleeding, eliminating scars, whitening and the like is often used. The traditional Chinese medicine Carthami flos is dried flower of Carthamus tinctorius L. Has effects of promoting blood circulation, promoting metabolism, inhibiting melanin formation or decomposing pigment to discharge from body, and caring skin. For example, chinese patent CN107823083A discloses a traditional Chinese medicine composition for removing chloasma and a preparation method thereof, wherein the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 10-30 parts of bighead atractylodes rhizome, 10-30 parts of white paeony root, 10-30 parts of angelica dahurica, 20-40 parts of bletilla, 5-20 parts of Japanese ampelopsis, 6-20 parts of white poria, 6-12 parts of pearl powder, 3-10 parts of rose, 2-9 parts of safflower, 3-10 parts of persimmon leaves, 9-25 parts of tribulus terrestris and 5-10 parts of honey. Respectively heating traditional Chinese medicines such as Atractylodis rhizoma with microwave for 10-20min, naturally cooling, pulverizing respectively, sieving with 200 mesh sieve, adding into water according to a material-to-liquid ratio of 1:5, heating at 60-80 deg.C for 30min, stirring at 100 deg.C for 50min, filtering, mixing the residue with Mel, and stirring to obtain paste. The Chinese patent CN107823083A has the main defects that the decoction dregs of the traditional Chinese medicine after hot water extraction are taken as effective whitening components, wherein the decoction dregs comprise rhizoma bletillae and safflower, the preparation method can cause the loss of water-soluble effective components, and the unreasonable preparation method can cause the loss of the meaning of the compatibility of the traditional Chinese medicine composition.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a gel type safflower whitening mask and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a gel type safflower whitening mask comprises the following components in percentage by weight: 1-4% of rhizoma bletillae alcohol precipitation liquid, 1-4% of safflower water extract, 0.04-0.4% of whitening enhancer, 0.01-0.05% of sodium hyaluronate, 0.05-0.5% of allantoin, 3-7% of carbomer, 5-20% of glycerol, 5-20% of butanediol, 0.1-0.6% of methylparaben and the balance of deionized water; the rhizoma bletillae alcohol precipitation liquid contains 0.1g of crude drug per milliliter, and the preparation method of the rhizoma bletillae alcohol precipitation liquid comprises the following steps: adding 10-50 times of deionized water into rhizoma Bletillae powder, reflux extracting for 1-3h, concentrating the filtrate, adding ethanol to make ethanol content 10-25% (V/V), centrifuging to obtain supernatant, concentrating the supernatant, adding ethanol to make ethanol content 70-80% (V/V), standing, collecting supernatant, and concentrating under reduced pressure to obtain extract containing crude drug 0.1g per ml; the safflower water extract contains 0.1g of crude drug per milliliter, and the preparation method of the safflower water extract comprises the following steps: adding 20-50 times of deionized water into Carthami flos powder, leaching with 30-50 deg.C hot water for 1-3 hr, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain crude drug 0.1g per ml; the whitening reinforcing agent is one or two of sodium zinc ethylenediamine tetraacetate and vitamin C.
Preferably, the weight percentage of the ethylene diamine tetraacetic acid zinc sodium is 0.02-0.05%, and the weight percentage of the vitamin C is 0.1-0.4%.
Preferably, the sodium hyaluronate is low molecular sodium hyaluronate, and the molecular weight of the low molecular sodium hyaluronate is 35-45 ten thousand.
Preferably, the gel type safflower whitening mask also comprises a complexing agent, wherein the complexing agent is one or two of morin and chitosan, the weight percentage of the morin is 0.03-0.06%, and the weight percentage of the chitosan is 1-4%.
Preferably, the gel type safflower whitening mask comprises 1% of rhizoma bletillae alcohol precipitation liquid, 4% of safflower water extract, 0.03% of ethylene diamine tetraacetic acid sodium, 0.2% of vitamin C, 0.03% of sodium hyaluronate, 0.2% of allantoin, 5% of carbomer, 10% of glycerol, 5% of butanediol, 0.5% of methylparaben, 0.03% of morin, 3% of chitosan and the balance of deionized water.
The invention provides a preparation method of a gel type safflower whitening mask, which comprises the following steps:
(1) taking rhizoma Bletillae ethanol precipitation solution, flos Carthami water extraction solution, whitening intensifier, sodium hyaluronate, allantoin, glycerol, butanediol, and methyl hydroxybenzoate, adding appropriate amount of deionized water, stirring at 40-50 deg.C, adding carbomer, and standing for 8-12 hr to obtain ointment;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging. In the step (1), a proper amount of deionized water accounts for 70-90% of the total amount of the deionized water.
Preferably, the preparation method of the gel type safflower whitening mask comprises the step (1) of adding a complexing agent.
The invention provides application of a gel type safflower whitening mask, and the gel type safflower whitening mask is used for reducing chloasma and black spots caused by acne.
Tyrosinase, also known as polyphenol oxidase, is a key rate-limiting enzyme in the process of melanin biosynthesis in organisms. In the process of melanin formation, tyrosinase can catalyze L-tyrosine to generate L-dopa, the L-dopa is gradually oxidized into dopaquinone, and pigment particles are further formed, and the excessive activity of the pigment particles can cause the symptoms of pigmentation, chloasma, freckles, senile plaques and the like. Therefore, tyrosinase inhibitory activity is often used for evaluating the freckle removing and whitening effects of whitening cosmetics, and tyrosinase inhibitors such as kojic acid, arbutin and the like are widely applied to cosmetics and skin care products as whitening agents.
Bletilla striata is a dried tuber of the plant Bletilla striata (Thunb.) reichb.f. of the family orchidaceae. Collected in summer and autumn, removed fibrous root, cleaned, boiled in boiling water or steamed until there is no white core, sun-dried to half dry, removed peel, and sun-dried. Its main functions are astringing to stop bleeding, detumescence and promoting granulation. Can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin. Bletilla striata is also used for whitening, but is often used in combination with other traditional Chinese medicines or in the form of aqueous bletilla striata extracts. The Carthami flos is dried flower of Carthamus tinctorius L. Has effects of promoting blood circulation, promoting metabolism, inhibiting melanin formation or decomposing pigment to discharge from body, and caring skin.
The research of the invention shows that the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid have obvious tyrosinase inhibiting activity, can effectively reduce chloasma and black spots caused by acne, and have the effects of removing freckles, whitening and moisturizing. The research of the invention simultaneously shows that the bletilla striata water extract has weak tyrosinase inhibitory activity, the bletilla striata polysaccharide does not have the tyrosinase inhibitory activity, and the bletilla striata polysaccharide has strong viscosity, thus being not beneficial to the preparation of the mask. Therefore, compared with a rhizoma bletillae water extract, the rhizoma bletillae alcohol precipitation liquid has the advantages that tyrosinase inhibitory active substances are effectively enriched, the purity is higher, and the safety is higher. The research of the invention simultaneously shows that when the rhizoma bletillae alcohol precipitation solution and the safflower water extraction solution are mixed according to a certain proportion, the activity of inhibiting the tyrosinase is higher than that of singly using the rhizoma bletillae alcohol precipitation solution or the safflower water extraction solution, which indicates that the two are compounded to have a synergistic effect and can enhance the activity of inhibiting the tyrosinase.
Sodium hyaluronate is one of the constituents of human skin, exists in connective tissue, and has good moisturizing effect because sodium hyaluronate contains a large amount of carboxyl and hydroxyl, and hydrogen bonds in molecules and among molecules are formed in aqueous solution. The low molecular weight sodium hyaluronate can quickly permeate into the dermis to hydrate and soften the cuticle of the skin, so that the whitening active ingredients in the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid can reach the dermis through the epidermis to better exert the effect.
The research of the invention shows that the whitening reinforcing agents of the sodium zinc ethylene diamine tetraacetate and the vitamin C can improve the inhibitory activity of the rhizoma bletillae alcohol precipitation liquid and the safflower water extract on tyrosinase, and are beneficial to the whitening effect of the rhizoma bletillae alcohol precipitation liquid and the safflower water extract. Especially, when the sodium zinc ethylene diamine tetraacetate and the vitamin C are used together, the inhibition activity of the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid on the tyrosinase is greatly improved, and the synergistic effect is realized. The zinc ions in the ethylene diamine tetraacetic acid zinc sodium can inhibit the activity of tyrosinase in a mode of not being combined with a substrate, so that the activity of the tyrosinase is reduced; vitamin C can interrupt melanin production process, prevent generated dopamine from being further oxidized and reduced into dopa, reduce oxidase content in serum, and reduce tyrosinase activity, thereby interfering melanin biosynthesis.
The facial mask contains allantoin, and the allantoin can enhance the capability of skin keratinocytes; meanwhile, allantoin also acts on proteins in the stratum corneum directly to enhance the water binding capacity of the stratum corneum, and has the function of moisturizing.
At present, some cosmetics in the market contain heavy metal components, such as harmful compounds of lead, mercury and the like, and can damage the skin after long-term use, so that the skin is aged and wrinkles are generated. The chitosan and morin can complex facial Pb through amino and hydroxyl in molecules2+、Hg2+、Ni2+The heavy metal ions are removed from the skin, and the harm of the heavy metal is reduced.
Compared with the existing whitening mask, the whitening mask has the following beneficial effects:
1. the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid used in the invention can effectively inhibit the activity of tyrosinase and effectively reduce chloasma and black specks caused by acne. The rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid have definite effects as whitening active ingredients, and the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid have a synergistic effect when being compounded for use, so that the whitening capacity is enhanced; meanwhile, the rhizoma bletillae alcohol precipitation solution and the safflower water extraction solution are extracted from natural plants, have rich sources, belong to renewable resources, and are green and environment-friendly.
2. The sodium zinc ethylene diamine tetraacetate and the vitamin C used in the invention can inhibit the activity of tyrosinase and block the generation of melanin, can improve the inhibition activity of rhizoma bletillae alcohol precipitation liquid and safflower water extraction liquid on the tyrosinase, improve the whitening effect of the gel safflower whitening mask, and have the function of synergy.
3. The chitosan and morin used in the present invention can remove facial Pb2+、Hg2+、Ni2+The heavy metal ions reduce the harm of skin aging and wrinkles caused by heavy metals.
4. The low-molecular sodium hyaluronate used in the invention can penetrate into the dermis layer, hydrate and soften the stratum corneum of skin, and can effectively improve the dry and uncomfortable feeling of the skin after the mask is used; meanwhile, the composition has the effects of promoting metabolism, improving skin nutrition absorption, and promoting absorption of rhizoma bletillae alcohol precipitation solution and safflower water extraction solution.
5. The facial mask can block the contact between the facial skin and the air in the using process, effectively prevent the evaporation of water, increase the humidity of the horny layer and soften the horny layer; can also dilate pores on the surface of the skin, and is beneficial to the absorption of nutrient components.
Detailed Description
The gel type safflower whitening mask of the present invention will be described in detail with reference to the following specific examples, but the scope of the present invention is not limited thereto. In the following examples, the percentages referred to are by weight unless otherwise indicated.
Example 1
1% of rhizoma bletillae alcohol precipitation liquid, 4% of safflower water extraction liquid, 0.03% of ethylene diamine tetraacetic acid sodium, 0.2% of vitamin C, 0.03% of sodium hyaluronate, 0.2% of allantoin, 5% of carbomer, 10% of glycerol, 5% of butanediol, 0.5% of methylparaben, 0.03% of morin, 3% of chitosan and the balance of deionized water.
The preparation method comprises the following steps:
(1) taking 1 weight part of rhizoma bletillae alcohol precipitation liquid, 4 weight parts of safflower water extract, 0.03 weight part of ethylene diamine tetraacetic acid zinc sodium, 0.2 weight part of vitamin C, 0.03 weight part of sodium hyaluronate, 0.2 weight part of allantoin, 10 weight parts of glycerin, 5 weight parts of butanediol, 0.5 weight part of methylparaben, 0.03 weight part of morin and 3 weight parts of chitosan, adding a proper amount of deionized water, stirring uniformly at 40-50 ℃, adding 5 weight parts of carbomer, and standing for 9 hours to obtain a paste body;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
Example 2
2% of rhizoma bletillae alcohol precipitation liquid, 3% of safflower water extraction liquid, 0.02% of ethylene diamine tetraacetic acid sodium, 0.1% of vitamin C, 0.05% of sodium hyaluronate, 0.1% of allantoin, 3% of carbomer, 10% of glycerol, 15% of butanediol, 0.1% of methylparaben, 0.05% of morin, 4% of chitosan and the balance of deionized water.
The preparation method comprises the following steps:
(1) taking 2 parts by weight of rhizoma bletillae alcohol precipitation liquid, 3 parts by weight of safflower water extract, 0.02 part by weight of ethylene diamine tetraacetic acid zinc sodium, 0.1 part by weight of vitamin C, 0.05 part by weight of sodium hyaluronate, 0.1 part by weight of allantoin, 10 parts by weight of glycerol, 15 parts by weight of butanediol, 0.1 part by weight of methylparaben, 0.05 part by weight of morin and 4 parts by weight of chitosan, adding a proper amount of deionized water, stirring uniformly at 40-50 ℃, adding 3 parts by weight of carbomer, and standing for 8 hours to obtain a paste body;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
Example 3
1% of rhizoma bletillae alcohol precipitation liquid, 4% of safflower water extraction liquid, 0.04% of ethylene diamine tetraacetic acid zinc sodium, 0.03% of sodium hyaluronate, 0.3% of allantoin, 4% of carbomer, 15% of glycerol, 10% of butanediol, 0.3% of methylparaben, 0.06% of morin and the balance of deionized water.
The preparation method comprises the following steps:
(1) taking 1 weight part of rhizoma bletillae alcohol precipitation liquid, 4 weight parts of safflower water extract, 0.04 weight part of ethylene diamine tetraacetic acid zinc sodium, 0.03 weight part of sodium hyaluronate, 0.3 weight part of allantoin, 15 weight parts of glycerin, 10 weight parts of butanediol, 0.3 weight part of methyl paraben and 0.06 weight part of morin, adding a proper amount of deionized water, stirring uniformly at 40-50 ℃, adding 4 weight parts of carbomer, and standing for 10 hours to obtain a paste body;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
Example 4
4% of rhizoma bletillae alcohol precipitation liquid, 1% of safflower water extract, 0.4% of vitamin C, 0.04% of sodium hyaluronate, 0.05% of allantoin, 5% of carbomer, 5% of glycerol, 20% of butanediol, 0.6% of methylparaben, 1% of chitosan and the balance of deionized water.
The preparation method comprises the following steps:
(1) taking 4 parts by weight of rhizoma bletillae alcohol precipitation liquid, 1 part by weight of safflower water extract, 0.4 part by weight of vitamin C, 0.04 part by weight of sodium hyaluronate, 0.05 part by weight of allantoin, 5 parts by weight of glycerol, 20 parts by weight of butanediol, 0.6 part by weight of methyl paraben and 1 part by weight of chitosan, adding a proper amount of deionized water, stirring uniformly at 40-50 ℃, adding 5 parts by weight of carbomer, and standing for 12 hours to obtain a paste body;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
Example 5
3% of rhizoma bletillae alcohol precipitation liquid, 2% of safflower water extract, 0.05% of ethylene diamine tetraacetic acid sodium, 0.04% of sodium hyaluronate, 0.5% of allantoin, 6% of carbomer, 20% of glycerol, 5% of butanediol, 0.4% of methylparaben, 0.04% of morin, 2% of chitosan and the balance of deionized water.
The preparation method comprises the following steps:
(1) taking 3 parts by weight of rhizoma bletillae alcohol precipitation liquid, 2 parts by weight of safflower water extract, 0.05 part by weight of sodium ethylene diamine tetraacetate, 0.04 part by weight of sodium hyaluronate, 0.5 part by weight of allantoin, 20 parts by weight of glycerol, 5 parts by weight of butanediol, 0.4 part by weight of methyl paraben, 0.04 part by weight of morin and 2 parts by weight of chitosan, adding a proper amount of deionized water, stirring uniformly at 40-50 ℃, adding 6 parts by weight of carbomer, and standing for 8 hours to obtain a paste body;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
Example 6
2% of rhizoma bletillae alcohol precipitation liquid, 3% of safflower water extraction liquid, 0.03% of ethylene diamine tetraacetic acid sodium, 0.3% of vitamin C, 0.01% of sodium hyaluronate, 0.2% of allantoin, 7% of carbomer, 10% of glycerol, 5% of butanediol, 0.5% of methylparaben and the balance of deionized water.
The preparation method comprises the following steps:
(1) taking 2 parts by weight of rhizoma bletillae alcohol precipitation liquid, 3 parts by weight of safflower water extract, 0.03 part by weight of ethylene diamine tetraacetic acid zinc sodium, 0.3 part by weight of vitamin C, 0.01 part by weight of sodium hyaluronate, 0.2 part by weight of allantoin, 10 parts by weight of glycerol, 5 parts by weight of butanediol and 0.5 part by weight of methylparaben, adding a proper amount of deionized water, stirring uniformly at 40-50 ℃, adding 7 parts by weight of carbomer, and standing for 10 hours to obtain a paste body;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
Examples of the experiments
Experimental example 1 study on tyrosinase inhibitory activity of rhizoma Bletillae alcohol-precipitated solution and flos Carthami water-extracted solution
Preparation of PBS buffer: respectively weighing sodium dihydrogen phosphate and disodium hydrogen phosphate, dissolving in 100mL volumetric flask with water, diluting to 100mL, respectively preparing 0.2mol/L solution of disodium hydrogen phosphate and sodium dihydrogen phosphate, and dissolving in 51: 49, measured with a pH meter and adjusted to pH 6.8.
Preparation of L-dopa solution: 0.0246g of L-dopa is precisely weighed and dissolved by adding 50mL of PBS buffer solution to obtain 2.5mM L-dopa solution.
Preparation of tyrosinase solution: accurately weighing tyrosinase, preparing 200U/mL enzyme solution with PBS buffer solution, freezing and storing at-20 deg.C, and thawing at 4 deg.C before use.
Preparation of sample solution: carrying out alcohol precipitation on rhizoma bletillae and a water extraction solution of safflower according to the ratio of 0: 5. 1: 4. 2: 3. 3: 2. 4: 1. 5: mixing at a ratio of 0, and making into rhizoma Bletillae and Carthami flos compound liquid at different ratios. The concentrations of rhizoma bletilla alcohol precipitation solution and Carthami flos water extraction solution are both 100mg/mL (calculated according to crude drug amount).
The determination method comprises the following steps: according to each reaction group in the table 1, precisely transferring the test samples and respectively adding the test samples into a 96-well plate, uniformly mixing, reacting for 10min in a constant temperature box (25 ℃), rapidly adding 100 mu L L-dopa solution, uniformly mixing, reacting for 10min at constant temperature (25 ℃), immediately measuring the absorbance value at 475nm in an enzyme-labeling instrument to obtain the absorbance A of each reaction groupC1、AC2、AT1、AT2. The parallel tests were performed 3 times. The tyrosinase inhibiting activity of the samples was calculated according to the following formula:
tyrosinase activity inhibition rate ═ 1- (A)T1-AT2)/(AC1-AC2)]×100％
C1: no sample was added with tyrosinase.
C2: no sample and no tyrosinase was added.
T1: samples were added and tyrosinase was added.
T2: adding sample without tyrosinase
Table 1 reaction solution composition (n ═ 3)
Note: "-" is no solution added.
The results are shown in Table 2.
TABLE 2 tyrosinase activity inhibition rate of rhizoma Bletillae alcohol precipitation solution and Carthami flos water extraction solution
Experimental results show that the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid have obvious tyrosinase activity inhibition effect. And the inhibition activity of the compound liquid of the rhizoma bletillae alcohol precipitation liquid and the safflower water extract is higher than that of the compound liquid of the rhizoma bletillae alcohol precipitation liquid and the safflower water extract which are singly used, and when the mass ratio of the rhizoma bletillae alcohol precipitation liquid to the safflower water extract is 1: 4, there is the greatest tyrosinase inhibition. The invention can effectively reduce chloasma and black spots caused by acne, and has the functions of removing freckles, whitening and moisturizing.
Experimental example 2 study on tyrosinase inhibitory activity of bletilla striata polysaccharide and bletilla striata water extract
The tyrosinase inhibitory activity of bletilla polysaccharide and bletilla water extract with different concentrations was determined by the same method as in experimental example 1, and the results are shown in tables 3 and 4.
TABLE 3 inhibition of tyrosinase activity by bletilla striata polysaccharides
TABLE 4 tyrosinase activity inhibition rate of aqueous extract of rhizoma Bletillae
The experimental result shows that compared with the rhizoma bletillae alcohol precipitation liquid, the rhizoma bletillae water extraction liquid has lower tyrosinase activity inhibition rate, and the rhizoma bletillae polysaccharide with various concentrations has no obvious inhibition effect on tyrosinase, which indicates that the rhizoma bletillae polysaccharide and the rhizoma bletillae water extraction liquid are not whitening effective components of rhizoma bletillae.
Experimental example 3
The compound liquid is prepared according to the proportion of the alcohol precipitation liquid of the bletilla striata, the water extraction liquid of the safflower and the whitening reinforcing agent in the embodiment of the invention, the compound liquid prepared according to the embodiment 1 is marked as compound liquid 1, and the compound liquid prepared according to the embodiment 3 is marked as compound liquid 3. The compound liquid prepared according to the proportion of the alcohol precipitation liquid of the bletilla striata and the water extract of the safflower in the embodiment 1 of the invention is marked as a contrast compound liquid. The inhibitory activity of the complex liquid 1, the complex liquid 3 and the control complex liquid on tyrosinase was determined by the same method as in experimental example 1, and the concentrations of the alcohol precipitated liquid of bletilla striata and the aqueous extract of safflower were both 100mg/mL (calculated by crude drug), and the results are shown in table 5.
TABLE 5 tyrosinase activity inhibition rate for each sample
The experimental results of the compound liquid 1, the compound liquid 3 and the comparison compound liquid show that under the condition that the concentrations and the proportions of the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid are the same, the ethylene diamine tetraacetic acid zinc sodium and the vitamin C can improve the inhibition effect of the rhizoma bletillae alcohol precipitation liquid and the safflower water extraction liquid on tyrosinase, and can enhance the whitening effect of the safflower whitening mask.
Claims (6)
1. The gel type safflower whitening mask is characterized by comprising the following components in percentage by weight: 1-4% of rhizoma bletillae alcohol precipitation liquid, 1-4% of safflower water extract, 0.04-0.4% of whitening enhancer, 0.01-0.05% of sodium hyaluronate, 0.05-0.5% of allantoin, 3-7% of carbomer, 5-20% of glycerol, 5-20% of butanediol, 0.1-0.6% of methylparaben and the balance of deionized water;
the rhizoma bletillae alcohol precipitation liquid contains 0.1g of crude drug per milliliter, and the preparation method of the rhizoma bletillae alcohol precipitation liquid comprises the following steps: adding 10-50 times of deionized water into rhizoma Bletillae powder, reflux extracting for 1-3h, concentrating the filtrate, adding ethanol to make ethanol content 10-25% (V/V), centrifuging to obtain supernatant, concentrating the supernatant, adding ethanol to make ethanol content 70-80% (V/V), standing, collecting supernatant, and concentrating under reduced pressure to obtain extract containing crude drug 0.1g per ml;
the preparation method of the safflower water extract comprises the following steps: adding 20-50 times of deionized water into Carthami flos powder, leaching with 30-50 deg.C hot water for 1-3 hr, centrifuging, collecting supernatant, and concentrating under reduced pressure to obtain crude drug 0.1g per ml;
the whitening reinforcing agent is one or two of sodium zinc ethylene diamine tetraacetate and vitamin C;
the weight percentage of the ethylene diamine tetraacetic acid zinc sodium is 0.02-0.05%, and the weight percentage of the vitamin C is 0.1-0.4%.
2. The gel-type safflower whitening mask according to claim 1, wherein the sodium hyaluronate is low molecular sodium hyaluronate, and the molecular weight of the low molecular sodium hyaluronate is 35 to 45 ten thousand.
3. The gel type safflower whitening mask according to any one of claims 1 to 2, further comprising a complexing agent, wherein the complexing agent is one or two of morin and chitosan, the morin accounts for 0.03 to 0.06 percent by weight, and the chitosan accounts for 1 to 4 percent by weight.
4. The gel type safflower whitening mask according to claim 3, which is characterized by comprising the following components in percentage by weight: 1% of rhizoma bletillae alcohol precipitation liquid, 4% of safflower water extraction liquid, 0.03% of ethylene diamine tetraacetic acid sodium, 0.2% of vitamin C, 0.03% of sodium hyaluronate, 0.2% of allantoin, 5% of carbomer, 10% of glycerol, 5% of butanediol, 0.5% of methylparaben, 0.03% of morin, 3% of chitosan and the balance of deionized water.
5. The preparation method of the gel type safflower whitening mask according to claim 1, which is characterized by comprising the following steps:
(1) taking rhizoma bletilla alcohol precipitation solution, flos Carthami water extract, whitening intensifier, sodium hyaluronate, allantoin, glycerol, butanediol, methyl hydroxybenzoate, adding appropriate amount of deionized water, stirring at 40-50 deg.C, adding carbomer, and standing for 8-12 hr to obtain ointment;
(2) placing the paste in a vacuum stirrer, adding deionized water to make up the balance, stirring uniformly in vacuum, and packaging.
6. The method for preparing the gel-type safflower whitening mask according to claim 5, wherein a complexing agent is further added in the step (1).
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| CN106039022A (en) * | 2016-07-20 | 2016-10-26 | 北京康盛源泰科技有限公司 | Skin brightening and whitening traditional Chinese medicinal composition, skin brightening and whitening traditional Chinese medicinal preparation, skin brightening and whitening mask and preparation method |
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| CN104983601A (en) * | 2015-07-06 | 2015-10-21 | 上海应用技术学院 | I-carrageenan gel mask and preparing method thereof |
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