CN109567758A - Across the scale photoacoustic imaging system of one kind - Google Patents
Across the scale photoacoustic imaging system of one kind Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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Abstract
The present invention provides across the scale photoacoustic imaging systems of one kind, including laser light source, light path system, switching device, sample and ultrasonic transducer；Switching device is fixed at least one described ultrasonic transducer for will be reflected into ultrasonic transducer on the pulsed laser irradiation to sample in light path system and by photoacoustic signal caused by sample in switching device；Switching device is set in the light path system, and light path system includes doubly clad optical fiber, and pulse laser is irradiated on sample using switching device after doubly clad optical fiber transmission and excites photoacoustic signal.Across the scale photoacoustic imaging system of one kind provided by the present invention solves the transmission of the photoacoustic imaging exciting light of optical resolution harmony credit two kinds of different scales of resolution using doubly clad optical fiber, thus greatly reduces the cost across scale photoacoustic imaging system；Switching device is used simultaneously to be used to photoacoustic signal caused by sample being reflected into ultrasonic transducer, has widened the investigative range of system significantly.
Description
Technical field
The present invention relates to Biologic Medical Image imaging fields, more particularly, to across the scale photoacoustic imaging system of one kind.
Background technique
Photoacoustic imaging (PAI) be a kind of non-invasive and unionized formula developed in recent years new bio medicine at
Image space method.Photoacoustic imaging has optical contrast abundant and Depth Imaging ability as a kind of novel hybrid imaging technology,
The shortcomings that overcoming the limitation and pure ultrasonic imaging poor contrast of pure optical imagery depth, has extensive biomedical clinical
Using.The principle of photoacoustic imaging is: exciting biological tissue with pulse laser, tissue can generate optoacoustic letter due to the thermal expansion of moment
Number (and ultrasonic wave), can detect the signal using ultrasonic transducer, to obtain tissue to the information of the degree of absorption of light.It visits
It is different to survey object, the photoacoustic signal frequency being excited is also different, so if when a system only has some frequency band
Detector when, it is possible to omit the signal of some wave band of testee.
Traditional optoacoustic microscopic system is distinguished from imaging resolution, is broadly divided into optical resolution optoacoustic microscopic system and sound
Credit resolution optoacoustic microscopic system.The characteristics of optical resolution optoacoustic microscopic system is to excite the diameter of hot spot to be less than in system
The focal spot of ultrasonic transducer, so the imaging resolution of the system depends on the size of excitation hot spot.Acoustics resolution ratio optoacoustic is aobvious
The hot spot of micro-system is much larger than the search coverage of ultrasonic transducer, therefore its imaging resolution depends on the focal spot of ultrasonic transducer
Size.The high resolution of traditional optical resolution optoacoustic microscopic system, up to several hundred nanometers to several microns, but imaging depth
Shallowly, about 1-2mm；The imaging depth of traditional acoustics resolution ratio optoacoustic microscopic system is big, and about several centimeters, but before resolution ratio is not so good as
Person reaches several hundred microns.Advantage and disadvantage based on the two, many seminars are dedicated to two kinds of imaging patterns being merged into a system
In, it realizes across scale imaging.
The Wang Lihong seminar of University of Washington in 2013 first proposed across scale opto-acoustic microscopic imaging system, the system
Mainly across scale micro-imaging is realized using fiber optic bundle.But fiber optic bundle is made of 10,000 fiber core with single-mold in the system, so that
The cost of whole system is high, and needs replacing entire fiber optic bundle if a certain single mode optical fiber damage in fiber optic bundle, makes
The use cost for the system of obtaining is high, and the optoacoustic for being only capable of acquiring single frequency range using single transducer is only capable of in the system
Signal, enable the system to using be limited in scope.
2014, German Estrada seminar also proposed across scale opto-acoustic microscopic imaging system.The system mainly utilizes
Mobile single mode optical fiber realizes across scale micro-imaging at a distance from self-focusing lens.Ultrasonic transducer needs in the system are opened
Hole, therefore the detection efficient of ultrasonic transducer will be greatly reduced.The same year, the Luo Qingming seminar of the Central China University of Science and Technology it is also proposed that
Across scale opto-acoustic microscopic imaging system.The system mainly utilizes fiber optic bundle to realize across scale micro-imaging.And the system exists
Following problems limit the range of imaging object, are more than for thickness first is that the system uses the signal acquisition mode of transmission-type
Several centimeters of object can not then be imaged；Second is that the system still use fiber optic bundle make whole system cost and use at
This height.
2018, the Yao person of outstanding talent seminar of Duke Univ USA proposed across the scale opto-acoustic microscopic imaging system of four mode.
The system maximum feature is that hot spot and acoustic blur are all changeable.But ultrasonic transducer used in the system is all center opening knot
Structure, the receiving efficiency of ultrasonic transducer will be greatly reduced in this, and two ultrasonic transducers are intelligently accessed in the system,
Therefore also only there are two frequencies for the system.
In order to reach good signal noise ratio (snr) of image, there are two key points for photoacoustic imaging: 1, optoacoustic is coaxial, 2 light focus harmony
The matching relationship of frequency.Coaxial so-called optoacoustic is exactly that the optical axis of exciting light is overlapped with the sound field axle center of ultrasonic transducer, is swashed in this way
It shines after being radiated at sample surfaces, photoacoustic signal is transmitted along axis opposite direction, can be received well by ultrasonic transducer.Light
Coaxial sound is best " excitation-reception " mode.Coaxial in order to reach optoacoustic, some seminars all select among ultrasonic transducer
Punching allows light to project from its center, but will be greatly reduced the performance of ultrasonic transducer in this way, reduces signal noise ratio (snr) of image.
Therefore, in existing across scale opto-acoustic microscopic imaging system, generally existing following problems: first, it needs in system
The fiber optic bundle formed using 10,000 single mode optical fibers cannot achieve the single light of replacement so that the cost of whole system is high
Fine and entire fiber optic bundle is needed to replace, use cost is high；Second, it needs when using ultrasonic transducer in system to the ultrasonic transduction
Device center opening reaches that optoacoustic is coaxial, this will will be greatly reduced the detection efficient of ultrasonic transducer；Third, it is anti-using transmitted light
The mode of ultrasound is penetrated, but is only capable of accessing single ultrasonic transducer or two ultrasonic transducers in system, therefore be only capable of receiving
The photoacoustic signal of certain frequency range can not cannot achieve across scale photoacoustic imaging to the covering of full frequency band photoacoustic signal, in addition when
When light is focused onto the hot spot of very little, resolution ratio is higher, and ordinary circumstance can all inspire the photoacoustic signal of high frequency, and work as light
When spot is larger, resolution ratio is lower, can generally inspire the photoacoustic signal of low frequency, therefore cannot be changed with the ultrasound of single frequency band
Can device come receive it is multiple dimensioned under photoacoustic signal, thus cannot achieve across scale photoacoustic imaging.
Summary of the invention
It is an object of the invention to solve to need in existing across scale photoacoustic imaging system using system caused by fiber optic bundle
At high cost and system is only capable of accessing the disadvantage that single ultrasonic transducer causes the investigative range of system limited, provides one kind across ruler
Spend photoacoustic imaging system.
The technical solution used to solve the technical problems of the present invention is that: a kind of across scale photoacoustic imaging system, including laser
Light source, light path system, switching device, sample and ultrasonic transducer；Wherein, the laser light source is for issuing pulse laser；Institute
Transmission of the light path system for the pulse laser between the laser light source and the sample is stated, the switching device is used for
It will be anti-on the pulsed laser irradiation to the sample in the light path system and by photoacoustic signal caused by the sample
It is mapped on the ultrasonic transducer, at least one described ultrasonic transducer is fixed in the switching device；The ultrasonic transduction
Device is used to receive the ultrasonic signal of the photoacoustic signal and/or internal loopback that reflect through the switching device；The switching
Device is set in the light path system, and the light path system includes doubly clad optical fiber, and the pulse laser passes through the double clad
It is irradiated on the sample after optical fiber transmission using the switching device and excites the photoacoustic signal.
Further, the doubly clad optical fiber includes fibre core, inner cladding and surrounding layer.
Specifically, the fibre core is used to carry out the excitation optical transport of optical resolution imaging pattern, and the inner cladding is used for
Carry out the excitation optical transport of acoustics resolution imaging mode.
Further, the switching device includes inner casing, is equipped with light source incidence mouth and light along optical path direction on the inner casing
Source exit portal, the sample are set at the light source exit portal, are additionally provided with signal perpendicular to the optical path direction on the inner casing
Exit portal.
Specifically, the ultrasonic transducer is fixed on the optoacoustic issued at the signal exit portal for receiving the sample
Signal.
Specifically, the switching device further includes the shell being sheathed on the outside of the inner casing, and the inner casing can be relatively described
Shell rotation, the shaft of the inner casing is parallel with the optical path direction, and the shell is equipped with to go out with the signal of the inner casing
The opening of loophole connection, the ultrasonic transducer are fixed on the photoacoustic signal that the opening is issued for receiving the sample.
Specifically, the switching device further includes being set in the inner casing to swash the pulse transmitted in the light path system
Light transmission on the sample and reflect the sample excitation photoacoustic signal light transmission-sound reflecting structure, the light is saturating
Penetrate-sound reflecting structure setting between the light source incidence mouth and the light source exit portal, and the light transmission-sound reflecting structure
Angle is formed with the optical path direction, the ultrasonic transducer is used to receive the light transmission-sound Jing Guo the switching device
The photoacoustic signal issued from the sample that catoptric arrangement is reflected.
Specifically, across the scale photoacoustic imaging system further includes mechanical scanning platform, the switching device and described super
Sonic transducer is set in the mechanical scanning platform.
Further, the light path system further includes set on the coupling between the laser light source and the doubly clad optical fiber
Lens are entered in the doubly clad optical fiber by spot coupling needed for adjusting the coupled lens acquisition.
Specifically, the light path system further includes poly- set on the imaging between the doubly clad optical fiber and the switching device
Focus lens, the imaging and focusing lens are used to the light that the doubly clad optical fiber is transmitted focusing on the sample.
A kind of beneficial effect across scale photoacoustic imaging system provided by the present invention is: using doubly clad optical fiber solution
The transmission of the photoacoustic imaging exciting light of optical resolution of having determined harmony credit two kinds of different scales of resolution, solves using fiber optic bundle
It the problem of as entire light path system is needed replacing after damage at high cost brought by optic path, thus greatly reduces across ruler
Spend the cost of photoacoustic imaging system；Switching device is used simultaneously to change for photoacoustic signal caused by sample to be reflected into ultrasound
Can on device, without the aperture on ultrasonic transducer, while can be added in switching device again ultrasonic transducer with extend across
The detection frequency range of scale photoacoustic imaging system, has widened the investigative range of system significantly.
Detailed description of the invention
Fig. 1 is the schematic diagram provided by the invention across scale photoacoustic imaging system；
Fig. 2 is the end view drawing of the doubly clad optical fiber provided by the invention across scale photoacoustic imaging system；
Fig. 3 is the schematic perspective view of the inner casing of the switching device provided by the invention across scale photoacoustic imaging system；
Fig. 4 is the front view of the inner casing of the switching device provided by the invention across scale photoacoustic imaging system；
Fig. 5 is the schematic perspective view of the shell of the switching device provided by the invention across scale photoacoustic imaging system；
Fig. 6 is the schematic perspective view of the switching device provided by the invention across scale photoacoustic imaging system；
Fig. 7 is the solid after the switching device provided by the invention across scale photoacoustic imaging system and ultrasonic transducer assembly
Structural schematic diagram.
In figure: across the scale photoacoustic imaging system of 100-
10- laser light source 20- light path system 30- switching device
40- sample 50- ultrasonic transducer 60- mechanical scanning platform
21- doubly clad optical fiber 22- coupled lens 23- imaging and focusing lens
211- fibre core 212- inner cladding 213- surrounding layer
24- beam processing system 31- shell 311- opening
312- through-hole 32- inner casing 33- light transmission-sound reflecting structure
321- light source incidence mouth 322- light source exit portal 323- signal exit portal
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
It is across the scale photoacoustic imaging system 100 of one kind provided by the present invention, including laser light source 10, optical path referring to Fig. 1
System 20, switching device 30, sample 40 and ultrasonic transducer 50.Wherein the laser light source 10 is used to issue pulsed laser light source,
And by be set to the hot spot of pulse laser that the beam processing system 24 in front of it is issued laser light source 10 carry out shaping it
It collimates in output light path system 20 afterwards.Transmission of the light path system 20 for the pulse laser between laser light source 10 and sample 40,
Include doubly clad optical fiber 21 in the light path system 20, " optical resolution " is realized by the doubly clad optical fiber 21 and " acoustics is differentiated
The excitation optical transport of two kinds of photoacoustic imaging modes of rate ".And the switching device 30 is set among light path system 20, is located at double clad
Between optical fiber 21 and sample 40, pulse laser is transmitted to sample 40 using switching device 30 after the transmission of doubly clad optical fiber 21
On.And the switching device 30 for will the pulsed laser irradiation that be transmitted in light path system 20 to sample 40, and by 40 institute of sample
The photoacoustic signal of generation is reflected on ultrasonic transducer 50, which is used to fix at least one ultrasonic transducer 50,
Fixed ultrasonic transducer 50 can be the ultrasonic transducer 50 of different frequency different function.Ultrasonic transducer 50 is for receiving warp
The ultrasonic signal of photoacoustic signal and/or internal loopback that switching device 30 reflects.Ultrasonic transducer 50 can be super with internal loopback
Acoustical signal needs to switch over its signal by the switching device 30.The switching device 30 is set in light path system 20, is used for
The pulse laser that transmission laser light source 10 is issued can also change the propagation path for the photoacoustic signal that sample 40 is issued, make
The propagation path for obtaining photoacoustic signal is vertical with optical path direction, so that the rotation by switching device 30 can be in the vertical of optical path direction
Multiple ultrasonic transducers 50 are set for receiving the photoacoustic signal that sample 40 is issued, the switching device 30 is by changing sample on face
The exit direction for the photoacoustic signal that product 40 are issued achievees the purpose that ultrasonic transducer 50 can be increased, without in ultrasound
The access of multiple ultrasonic transducers 50 can be realized in aperture on energy converter 50, and ensure that the coaxial propagation of photoacoustic signal, so that should
Across scale photoacoustic imaging system 100 can access multiple ultrasonic transducers 50 for receiving the signal of multiple frequency ranges simultaneously, realize
The signal detection of wide-band, can almost cover common low frequency to high frequency section signal.
Further, as shown in Fig. 2, doubly clad optical fiber 21 includes fibre core 211, inner cladding 212 and surrounding layer 213.This hair
It is transmitted using doubly clad optical fiber 21 as light source in the light path system 20 in across scale photoacoustic imaging system 100 provided in bright
Path, it is easy to operate, it can be achieved that the free switching of optical resolution harmony credit resolution is transmitted in system work process,
And traditional fiber bundle structure can be replaced, so that cost is relatively low for light path system 20, reached across two kinds of photoacoustic imagings of scale
Transmission.Specifically, which is the excitation optical transport for carrying out optical resolution imaging pattern, and inner cladding 212 is to use
In the excitation optical transport for carrying out acoustics resolution imaging mode.
Further, optical fiber resolution ratio optoacoustic microscopic system harmony credit resolution optoacoustic is broadly divided into optoacoustic microscopic system
Microscopic system.And the light path system 20 further includes leading to set on the coupled lens 22 between laser light source 10 and doubly clad optical fiber 21
It overregulates coupled lens 22 and obtains required spot coupling and enter in doubly clad optical fiber 21.By the position for adjusting the coupled lens 22
It sets, it can be with the size of free switching hot spot.And the imaging resolution of across scale photoacoustic imaging system 100 provided by the present invention takes
Certainly in the size of excitation hot spot.When carrying out optical resolution photoacoustic imaging, coupled light by the coupled lens 22
At the center of doubly clad optical fiber 21, i.e., in fibre core 211, pass through 211 transmission light source of fibre core of doubly clad optical fiber 21.When progress acoustics
When resolution imaging, by adjusting the distance between the coupled lens 22 and doubly clad optical fiber 21, so that saturating through overcoupling
Emergent light spot after mirror 22 is radiated on the inner cladding 212 of doubly clad optical fiber 21, passes through 21 transmission light source of doubly clad optical fiber.Cause
This, the issued pulsed laser light source of laser light source 10 is in the collimation processing that have passed through the beam processing system 24 in light path system 20
Coupled lens 22 are injected afterwards, and adjust the hot spot for entering doubly clad optical fiber 21 by the coupled lens 22, recycle double clad light
Fibre 21 carries out light source transmission.The coupling efficiency of the doubly clad optical fiber 21 is high, passes through the imaging of 22 free switching system of coupled lens
Mode, it is easy to operate, it is easy to accomplish.
Further, as shown in Figure 1, the light path system 20 further includes being set between doubly clad optical fiber 21 and switching device 30
Imaging and focusing lens 23, imaging and focusing lens 23 are used to the light that doubly clad optical fiber 21 is transmitted focusing on sample 40.It should
By 30 direct irradiation of switching device in sample after the pulse laser focusing that imaging and focusing lens 23 transmit doubly clad optical fiber 21
On 40.Sample 40 generates photoacoustic signal under the excitation of pulse laser, which is transmitted in switching device 30, by switching
The reflection of device 30 is transmitted to its photoacoustic signal in ultrasonic transducer 50, detects for ultrasonic transducer 50.
Further, across scale photoacoustic imaging system 100 provided by the present invention further includes mechanical scanning platform 60, switching
Device 30 and ultrasonic transducer 50 are set in mechanical scanning platform 60.Meanwhile doubly clad optical fiber 21 in light path system 20 and
Imaging and focusing lens 23 are also disposed in mechanical scanning platform 60.Across scale optoacoustic may be implemented by the mechanical scanning platform 60
Imaging system 100 carries out the function of zigzag progressive scan on sample 40.And the switching device 30 and ultrasonic transducer 50 then need
It is placed in water tank, the transparency liquid for being used for transmission photoacoustic signal is provided in water tank, generally using water as transmission medium.
Sample 40 be set to mechanical scanning platform 60 bottom, and switching device 30 be set to water tank water in, using the water in water tank as
Photon-phonon coupling agent, when the pulse laser exciting irradiation that sample 40 is exported by doubly clad optical fiber 21 generates photoacoustic signal, the optoacoustic
Signal encounters switching device 30 and then photoacoustic signal propagation path changes, to change ultrasound in the water transmission of water tank
The detection direction of energy converter 50.
Specifically, as shown in Figure 3-4, which includes inner casing 32, is equipped with light source along optical path direction on inner casing 32
Entrance port 321 and light source exit portal 322, sample 40 are set at light source exit portal 322, also set on inner casing 32 perpendicular to optical path direction
There is signal exit portal 323.The light source that the doubly clad optical fiber 21 is exported, which from top to bottom penetrates the switching device 30 and is irradiated to, to be located at
On the sample 40 of 30 lower section of switching device.The irradiation from top to bottom as shown in Figure 1 of the optical path direction of the switching device 30.Therefore,
It is equipped with light source incidence mouth 321 in the top of inner casing 32, is equipped with light source exit portal 322 in the lower section of inner casing 32, light source is by inner casing 32
Light source incidence mouth 321 inject, by light source exit portal 322 injection be irradiated on sample 40.Therefore, when sample 40 is excited generation
When photoacoustic signal is propagated in the water tank 60, ultrasonic transducer 50 is fixed on signal goes out at Shekou 322 to be used to receive sample 40 and send out
Photoacoustic signal out, at this time, it is only necessary to the receiving port of ultrasonic transducer 50 be arranged towards the direction of the sample 40, can be realized super
Sonic transducer 50 receives the photoacoustic signal that sample 40 issues.
Further, in order to improve the received sample 40 of ultrasonic transducer 50 sending photoacoustic signal receptance, reach
The coaxial effect of optoacoustic.The pulse transmitted in light path system 20 is swashed in inner casing as shown in Figure 1, the switching device 30 is also peeled off
Light transmission is on sample 40, and light transmission-sound reflecting structure 33 of photoacoustic signal that reflected sample 40 is excited, light transmission-sound
Catoptric arrangement 33 is set between light source incidence mouth 321 and light source exit portal 322, and light transmission-sound reflecting structure 33 and optical path
Direction forms angle, and being fixed on the ultrasonic transducer 50 at the signal exit portal 323 of inner casing 32 only need to be along the light transmission-sound
The direction for the photoacoustic signal that catoptric arrangement 33 is reflected is arranged, and it is coaxial that optoacoustic can be realized, and the ultrasonic transducer 50 is then used for
Receive the photoacoustic signal issued from sample 40 that light transmission-sound reflecting structure 33 Jing Guo switching device 30 is reflected.At this
In embodiment, the light transmission-sound reflecting structure 33 is the sheet glass of light transmission, be can be very good by the way that sheet glass is arranged by double clad
The pulse laser exported in optical fiber 21 is transmitted on sample 40, and the photoacoustic signal that sample 40 is issued is reflexed to ultrasound and is changed
In energy device 50.And the light transmission-sound reflecting structure 33 and optical path direction form angle, so that the photoacoustic signal that sample 40 is issued
It is projected by the reflection of light transmission-sound reflecting structure 33 along optical path direction is deviateed, i.e., the photoacoustic signal by reflection will be towards
The housing side of inner casing 32 projects.Preferably, the angle that the light transmission-is formed between sound reflecting structure 33 and optical path direction is
45 °, the photoacoustic signal for the sample 40 that such light transmission-sound reflecting structure 33 is reflected and horizontally disposed ultrasonic transducer 50
Direction is consistent, so that it is coaxial to reach optoacoustic.Light transmission-sound reflecting structure 33 in the switching device 30 does not change light source
Exposure pathways are only used for changing the propagation path of photoacoustic signal in water.Photoacoustic signal is propagated against optical path direction, and it is saturating to encounter light
Penetrate-barrier of sound reflecting structure 33 changes path, so that the photoacoustic signal is rotated by 90 ° the side outflow by switching device 30, this
When, be light transmissive-sound reflecting structure 33 change propagation path photoacoustic signal by be located at 32 side of inner casing signal exit portal
It is spread out of at 323.Therefore, as shown in Figure 1, the ultrasonic transducer 50 being somebody's turn to do in across scale photoacoustic imaging system 100 is fixed on letter
For receiving the ultrasound letter of photoacoustic signal and/or internal loopback that light transmission-sound reflecting structure 33 reflects at number exit portal 323
Number.A ultrasonic transducer 50 is provided only in the imaging system 100 to be used to detect the photoacoustic signal that sample 40 is issued, for
When needing across scale photoacoustic imaging, it can be realized by replacing the ultrasonic transducer 50.
Further, as shown in figure 5, in across scale photoacoustic imaging system 100 provided by the present invention, the switching device 30
It further include the shell 31 for being sheathed on 32 outside of inner casing.As shown in fig. 6, inner casing 32 is sheathed in shell 31.The inner casing 32 can be opposite
Shell 31 rotates, and the shaft of inner casing 32 is parallel with optical path direction.The inner casing 32 and shell 31 can be set to the circle being mutually arranged
Tubular structure, may be set to be 32 circle of position tubular structure of inner casing as shown in Figure 6, and shell 31 is rectangular structure.Such as Fig. 5
Shown, which is equipped with the opening 311 that can be connected to the signal exit portal 323 of inner casing 32, and ultrasonic transducer 50 is fixed on
Be open the photoacoustic signal issued at 311 for directly receiving sample 40.Light transmission-sound reflecting structure should be provided in inner casing 32
33, then the ultrasonic transducer 50 is for receiving the photoacoustic signal that light transmission-sound reflecting structure 33 is reflected.The switching device 30 is also
It can be relatively rotated including shell 31, and between shell 31 and inner casing 32, so that in the photoacoustic signal propagation side of the inner casing 32
Upwards, multiple ultrasonic transducers 50 can be added simultaneously for detecting photoacoustic signal, to widen the investigative range of system.It is being
In the operating process of system 100, by the relative position of rotary inner casing 32 and shell 31, so that the signal exit portal on inner casing 32
323 with the open communication of the ultrasonic transducer 50 of corresponding look-in frequency, the detection of required frequency can be realized.And the present invention is mentioned
In across the scale photoacoustic imaging system 100 supplied, multiple ultrasonic transducers can be accessed on the shell 31 of the switching device 30 simultaneously
50, the adjustment of look-in frequency is realized by the relative rotation of inner casing 32 and shell 31, which is not necessarily in ultrasonic transduction
Aperture on device 50, so as to avoid ultrasonic transducer 50 because aperture and caused by detection efficient reduce the problem of.
By the setting of the switching device 30, the quantity of ultrasonic transducer 50 can be increased simultaneously.Increased ultrasonic transduction
Device 50 can choose the ultrasonic transducer 50 of identical frequency but different mode.The ultrasound that 50 outside of switching device is arranged in is changed
Energy device 50 is the focused ultrasonic transducer 50 and out-focus formula ultrasonic transducer 50 of same frequency.Due to the light of acoustics resolution ratio
Its lateral resolution is determined by the detection focus area of ultrasonic transducer 50 in acoustic imaging, even therefore in switching device 30
The ultrasonic transducer 50 of identical frequency, different mode is set, the photoacoustic image of different scale can also be obtained simultaneously.Alternatively, increasing
If ultrasonic transducer 50 also can choose model identical, but the ultrasonic transducer that look-in frequency is different.Due to ultrasonic transduction
The longitudinal resolution of the look-in frequency meeting imaged image of device 50, look-in frequency is higher, and its longitudinal resolution is higher, thus while its
The type of focusing is consistent, can also obtain the photoacoustic image of different scale simultaneously.Or the ultrasonic transducer 50 added can select
The ultrasonic transducer for selecting different mode difference look-in frequency, the demand of the photoacoustic image to meet different scale.
Specifically, as shown in fig. 7, for switching device 30 in across scale photoacoustic imaging system 100 provided by the present invention with
Schematic perspective view after the assembling of ultrasonic transducer 50.As shown in Figure 7, it is somebody's turn to do in across scale photoacoustic imaging system 100
Including four ultrasonic transducers 50, and the shell 31 of the corresponding switching device 30 is in rectangular configuration, therefore in its vertical direction
It is equipped with through-hole 312 up and down, sets that there are four sides in its horizontal direction, corresponding, each side sets that there are four open
Mouth 311, and the cylindrical structure of inner casing 32, inner casing 32 are sheathed at the through-hole 312 of shell 31, inner casing 32 can be in the logical of shell 31
It is relatively rotated in hole 312.And the relative rotation between the inner casing 32 and shell 31 can be and manually adjust, and can also use automatically controlled
Rotation.And being located at the opening 311 on shell 31 can be emitted by the relative rotation of inner casing 32 and shell 31 and the signal of inner casing 32
Mouth 323 is connected to, and four ultrasonic transducers 50 are individually fixed at four openings 311.It, can be with by rotary inner casing 32 and shell 31
For the different ultrasonic transducer 50 of free switching for detecting the photoacoustic signal that sample 40 is issued, which acquires light
Ultrasonic imaging is carried out while acoustical signal.And in the present embodiment, which has been respectively adopted different detections
Frequency, the look-in frequency of four ultrasonic transducers 50 are respectively 5MHz, 10MHz, 30MHz, 75MHz, and ultrasonic transducer 50
Bandwidth be 100%, therefore their look-in frequency range is respectively 2.5MHz-7.5MHz, 5MHz-15MHz, 15MHz-
45MHz,38.5MHz-113.5MHz.Therefore by using switching in across scale photoacoustic imaging system 100 provided by the present invention
Device 30, four ultrasonic transducers 50 added, the investigative range that can be covered is in 2.5MHz-113.5MHz, to realize
Almost cover common low frequency to high frequency section signal.
On the one hand across the scale photoacoustic imaging system 100 of one kind provided by the present invention uses doubly clad optical fiber 21 and solves
The transmission of the photoacoustic imaging of optical resolution harmony credit two kinds of different scales of resolution, solves using fiber optic bundle as optical path
The problem of needing replacing entire light path system after damage at high cost brought by transmitting, thus greatly reduce across scale optoacoustic at
As the cost of system；On the other hand switching device 30 is used to change for photoacoustic signal caused by sample 40 to be reflected into ultrasound
On energy device 50, without the aperture on ultrasonic transducer 50, and ultrasonic transducer 50 can be added in switching device 30 to expand
The detection frequency range for opening up across scale photoacoustic imaging system 100, has widened the investigative range of system significantly.
The above is merely preferred embodiments of the present invention, be not intended to limit the invention, it is all in spirit of the invention and
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within principle.
Claims (10)
1. a kind of across scale photoacoustic imaging system, which is characterized in that including laser light source, light path system, switching device, sample and
Ultrasonic transducer；Wherein,
The laser light source is for issuing pulse laser；
Transmission of the light path system for the pulse laser between the laser light source and the sample,
The switching device is used for will be on the pulsed laser irradiation to the sample in the light path system and by the sample
Photoacoustic signal caused by product is reflected on the ultrasonic transducer, at least one described ultrasound is fixed in the switching device
Energy converter；
The ultrasonic transducer is used to receive the super of the photoacoustic signal and/or internal loopback reflected through the switching device
Acoustical signal；
The switching device is set in the light path system, and the light path system includes doubly clad optical fiber, the pulse laser warp
It is irradiated on the sample after crossing the doubly clad optical fiber transmission using the switching device and excites the photoacoustic signal.
2. a kind of across scale photoacoustic imaging system as described in claim 1, which is characterized in that the doubly clad optical fiber includes fibre
Core, inner cladding and surrounding layer.
3. a kind of across scale photoacoustic imaging system as claimed in claim 2, which is characterized in that the fibre core is for carrying out optics
The excitation optical transport of resolution imaging mode, the inner cladding are used to carry out the excitation optical transport of acoustics resolution imaging mode.
4. a kind of across scale photoacoustic imaging system as described in claim 1, which is characterized in that the switching device includes interior
Shell, is equipped with light source incidence mouth and light source exit portal along optical path direction on the inner casing, and the sample is set to the light source exit portal
Locate, is additionally provided with signal exit portal perpendicular to the optical path direction on the inner casing.
5. a kind of across scale photoacoustic imaging system as claimed in claim 4, which is characterized in that the ultrasonic transducer is fixed on
The photoacoustic signal issued at the signal exit portal for receiving the sample.
6. a kind of across scale photoacoustic imaging system as claimed in claim 4, which is characterized in that the switching device further includes set
Shell on the outside of the inner casing, the inner casing can be rotated relative to the shell, the shaft of the inner casing and the optical path side
To parallel, the shell is equipped with the opening that can be connected to the signal exit portal of the inner casing, and the ultrasonic transducer is fixed on
The opening is used to receive the photoacoustic signal that the sample issues.
7. such as across the scale photoacoustic imaging system of one kind described in claim 5 or 6, which is characterized in that the switching device is also wrapped
It includes and is set to the pulse laser transmitted in the light path system transmission in the inner casing on the sample and reflecting the sample
Light transmission-sound reflecting structure of the photoacoustic signal of product excitation, the light transmission-sound reflecting structure setting is in the light source incidence mouth
Between the light source exit portal, and the light transmission-sound reflecting structure and the optical path direction form angle, and the ultrasound is changed
Can the device light transmission-sound reflecting structure for being used to receive Jing Guo the switching device reflected from sample sending
Photoacoustic signal.
8. a kind of across scale photoacoustic imaging system as claimed in claim 4, which is characterized in that across the scale photoacoustic imaging system
System further includes mechanical scanning platform, and the switching device and the ultrasonic transducer are set in the mechanical scanning platform.
9. a kind of across scale photoacoustic imaging system as claimed in claim 2, which is characterized in that the light path system further includes setting
Coupled lens between the laser light source and the doubly clad optical fiber obtain required hot spot by adjusting the coupled lens
It is coupled into the doubly clad optical fiber.
10. across scale photoacoustic imaging system as claimed in claim 9 a kind of, which is characterized in that the light path system further includes
Imaging and focusing lens between the doubly clad optical fiber and the switching device, the imaging and focusing lens are used for will be described
The light that doubly clad optical fiber is transmitted focuses on the sample.
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