CN1095617A - The application of Rhizoma Ginseng and primordial QI reinforcing electuary and preparation method thereof - Google Patents
The application of Rhizoma Ginseng and primordial QI reinforcing electuary and preparation method thereof Download PDFInfo
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- CN1095617A CN1095617A CN 93120971 CN93120971A CN1095617A CN 1095617 A CN1095617 A CN 1095617A CN 93120971 CN93120971 CN 93120971 CN 93120971 A CN93120971 A CN 93120971A CN 1095617 A CN1095617 A CN 1095617A
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Abstract
The present invention relates to the application of Rhizoma Ginseng and utilize Rhizoma Ginseng to prepare the method for primordial QI reinforcing electuary, the present invention points out that Rhizoma Ginseng has effect and the effect identical with the Radix Ginseng main root, has changed the conventional practice that Radix Ginseng goes reed.It is with Rhizoma Ginseng through cleaning, extract, concentrate, drying and pulverizing be made into Rhizoma Ginseng and extract powder; and with Radix Astragali crude polysaccharide powder through mix, granulate makes; it has can make macrophage function and E-rosette formation rate be significantly improved; can make the too much Ts cell of patients with advanced cancer be subjected to certain inhibition, it has certain protection and raising effect to the leukocyte of patient in radiation and chemotherapy.
Description
The present invention relates to the application of Rhizoma Ginseng and utilize Rhizoma Ginseng to prepare the method for primordial QI reinforcing electuary.
Removing LU is used as medicine that to use be an arguement problem for a long time to Radix Ginseng, the argument of comprehensive medical ancient books, can reduce: one, for repairing and renovate (or purifying and cutting) angle, carry as " Thunder God is concocted opinion ": " must not dry in the shade; go four limit reed heads and black person, during file is used as medicine ", or " removing the reed stalk " (" book on Chinese herbal medicine covers an aromatic plant metioned in ancient books "), " go reed must, grind be the end " (" Compendium of medicine ").Think two, " remove its reed head, do not go to tell the people " that " telling " is emetic action, similar to the effect of vomitting of causing of the pawl base of a fruit, Rhizoma et radix veratri (Radix Rhizoma Veratri).Three, do not indicate that Radix Ginseng need go reed, according to not mentioning in the Shennong's Herbal that Radix Ginseng need go reed one thing.
In addition, tumor patient is taken novel drugs such as batilol, leucogen more at present, and leukocyte count is sharply descended, and rate of descent is 53%, causes patient to be forced to therapy discontinued, and it can not be taken separately.
The purpose of this invention is to provide the new medicinal part of a kind of Chinese crude drug---the application of Rhizoma Ginseng and utilize Rhizoma Ginseng to prepare the method for primordial QI reinforcing electuary.
Past is by traditional habit, after often Rhizoma Ginseng being removed, can be used as medicine, in order to change this prejudice, research and clinical trial by analysis, from Rhizoma Ginseng, isolated Radix Ginseng soap formula Ro.Rb1.Rb2.Rc.Rd.Re.Rg1.Rg2, find that Rhizoma Ginseng and the contained ginsenoside's number of Radix Ginseng main root kind are basic identical, the first kind of the two contained general glycoside is also identical, the reed head contains Radix Ginseng total saponins and exceeds 2-3 doubly than Radix Ginseng main root content, in addition more than (seeing Table 1), difference (seeing Table 2) to some extent on total diosgenin content and the various glycoside unit ratio, except that the Saponin composition of ginseng reed, volatile oil is arranged still, aminoacid, polypeptide and trace element (seeing Table 3).Whether go reed for solving Radix Ginseng, pharmacological experiment study, majority is started with emetic action, and its many-sided pharmacological action has been carried out further research relatively, returns row as follows: 1, not have emetic action (seeing Table 4); 2, the ginseng reed presents the activity similar to Radix Ginseng (seeing Table 5) more; 3, avirulence.The clinical observation of Rhizoma Ginseng is expansion (seeing Table 6) to some extent also, and it has write down denys the emetic abnormal response that waits, and has obtained the tonification and the therapeutic effect of similar Radix Ginseng, and in sum, Rhizoma Ginseng can be used as medicine, and its reason is: 1, have many records to go reed in the ancient work; 2, modern study finds no to cause and tells composition, and Rhizoma Ginseng is close with Radix Ginseng main root composition; 3, experimental pharmacology has not shown emetic action; 4, no emetic action is thought in clinical observation.
The total Saponin comparative study of table 1 ginseng reed and Radix Ginseng (main root)
Total saponin content (%) experiment sequence number is qualitative relatively to be annotated
The many Xiao Huang point red ginsengs of ginseng Lu Rencan 1 14.4 4.9 number kinds basically identical gravimetric method 2 14.1 4.5 colorimetric methods 3 6.23 2.754 7.4 2.9～3.25 6.4 3.46 17.46 5.227 14.56 4.28 main roots and reed 8 12.41 4.22
Table 2 ginseng reed and the comparative study of Radix Ginseng total saponins unit
| Content (%) | Various distribution or content (%) | The experiment sequence number | ||
| O type diol type triol type d/T | ||||
| Ginseng Lu Rencan | ????4.92 ????2.16 | ??8.90????30.20??????38.63 ??6.70????43.00??????41.00 | Various data down are the % that accounts for general glycoside unit | ????1 |
| Ginseng Lu Rencan | ??1.14????4.53???????1.94???????2.3/1 ??1.11????2.19???????0.98???????2.5/1 | ????2 |
The comparative study of table 3 ginseng reed and other compositions of Radix Ginseng
| Composition ginseng reed | Radix Ginseng |
| 8 kinds of the sesquiterpenes that the volatile oil total content is about 3 times of M/Z204 of root account for 9.4% of volatile oil and identify 24 kinds of compositions | Be about 11～18 kinds of the sesquiterpenes of reed 1/3 M/Z204, account for volatile oil 36.5～42.86% |
| Zheng Shi identifies 7 kinds of chemical compounds. | |
| Aminoacid detects 6 kinds of amino acid/11s, content O.5%, glutamic acid content is the highest | Detect 15 kinds, content O.5%, threonine content is the highest |
| Polypeptide tetradecapeptide I is similar to one of ginseng root 14 peptides. | |
| The trace element human body must trace element adds and measures average and is higher than main root. | Contain element more than 18 kinds |
The comparative study laboratory animal dose and the route of administration result of table 4 ginseng reed emetic action annotate the total Saponin 200mg/kg of Canis familiaris L. per os
Reed powder 200mg/kg " does not all cause and tells
600mg/kg " cat 200mg/kg " Canis familiaris L. 18g/kg " does not see to cause and tells rabbit 10%; 50% decocting liquid 3.2ml/kg " " pigeon 15g/kg (decocting liquid) " " does not go the Lu Hongcan cat; Canis familiaris L.; the equal 20g/kg of Rhesus Macacus (decocting liquid) " " contrast, do not tell
Other pharmacological action comparative study of table 5 ginseng reed
| Pharmacological action | The ginseng reed | Radix Ginseng | |
| The dosage result | The dosage result | ||
| To each internal organs ATP enzymatic activity impact | Cardiac muscle | General glycoside 500 μ g/ml suppress Total-ATPase and lead 81.5% inhibition Mg 2+-ATPase leads 90.3% and activates Na +-K +-ATPase leads 354% general glycoside, 500 μ g/ml increases the active 123% inhibition Mg of Total-ATPase 2+-ATPase leads 12.2% and activates Na +-K +-ATPase leads 181% general glycoside, 500 μ g/ml inhibition Total-ATPase and leads 19.4% inhibition Mg 2+-ATPase leads 27.5% and activates Na +-K +-ATPase leads 151% general glycoside, 500 μ g/m1 increases the active 17.4% inhibition Mg of Total-ATPase 2+-ATPase leads 42.2% and activates Na +-K +-ATPase leads 241% general glycoside, 5500 μ g/ml inhibition Total-ATPase and leads 54.5% inhibition Mg 2+-ATPase leads 56.8% and activates Na +-K +-ATPase leads 217% | Inhibition 23.9% inhibition 31.7% activates 220% inhibition, 7.0% inhibition, 24.2% activation, 126% inhibition 16.1% and suppresses 21.2% activation, 140% inhibition, 18.1% inhibition, 17.6% activation 135% |
| Suppress lipid peroxidation | The vitro inhibition lipid peroxidation is better than VE | With a left side | |
Other pharmacological action comparative study of table 6 ginseng reed
| Pharmacological action | The ginseng reed | Radix Ginseng |
| The dosage result | The dosage result | |
| Resisting fatigue | The effective P of 5g/kg＜0.05 strengthens the mouse anti-reflecting fatigue ability and prolongs the mice 50.2% general glycoside 60mg/kg that swims and prolong mice swimming with a load attached to the body P＜0.05 | Prolong mice trip Shanghai 44.3% with a left side with a left side |
| Anoxia enduring | The effective P of 3g/kg＜0.05 general glycoside 60mg/kg prolongs existence P＜0.01 and improves 2.4 times of anoxia endurance prolongation existence | Prolong 2.9 times with a left side with a left side |
| High temperature resistant | The effective P of 4g/kg＜0.05 | ????P＜0.01 |
| Low temperature resistant | The effective P of 5g/kg＜0.05 | ????P＜0.05 |
| Diuresis | The effective P of the 5g/kg＜effective P of 0.05 general glycoside 60mg/kg＜0.01 | ????P＜0.05 ????P＜0.01 |
| Calm | 1. 3g/kg press down autonomic activities P＜0.01 2. 5g/kg influence penta barbital P＜0.01 | ????P＜0.05 ????P＜0.05 |
| Convulsion | 1. the anti-soil of 5g/kg decides the 2. anti-pentetrazole P of 5g/kg＜0.01, P＜0.05 | ????P＜0.05 ????P＜0.05 |
| Immunity | General glycoside improves lymphocyte cAMP.cGMP content, influencing E one rosette forms, general glycoside is to the spleen coefficient, and hemolysin is dual regulation the spleen cyclic nucleotide is dual regulation. | General glycoside is dual regulation to the board cyclic nucleotide |
| To the heart effect | It is synthetic to promote to cultivate cardiac muscle cell DNA; To lacking sugar, anoxic is cultivated the cardiac muscle cell protective effect. and general glycoside brings out the mouse ventricular fibrillation to chloroform protective effect. anti-barium chloride Aconitine Induced rat ventricular. the heart merit LVP rising 35% of experimental heart failure increases rabbit heart hat flow 38.2 ± 7.1% and improves heart contracting power 12.1 ± 4.3% | 43% increase by 36.1 ± 6.7% that raises improves 10.9 ± 3.4% |
| Blood vessel dilating | Rabbit ear perfusion increases by 9.7 ± 4.3% | Increase by 7.9 ± 2.3% |
More than the explanation Rhizoma Ginseng has effect and the effect identical with the Radix Ginseng main root, can be used as medicine, for new footpath is warded off in the application of Rhizoma Ginseng in addition.Moreover, the Radix Astragali has certain influence to the ring squama adenosine monophosphate (CGMP) in patient's blood plasma, experimental results show that deficiency of YIN patient CAMP content obviously increases, and yang deficiency patient CAMP content also increases, so the ratio of CAMP/CGMP obviously reduces in the yang deficiency patient, deficiency of YIN patient then denys, Radix Astragali extract product and warming YANG medicine can make the content of rat CAMP raise, it illustrates the relation of imbalance of YIN and YANG and cyclic nucleotides on the one hand, on the other hand also may be relevant with the content of interferon, in active ingredient screening process to the Radix Astragali, find that active ingredient F3 and F8 all can obviously improve the lymphocytic function of tumour patient T, the Radix Astragali crude polysaccharides Main Ingredients and Appearance in the primordial QI reinforcing electuary is F3.
The object of the present invention is achieved like this: put into extraction pot water extraction three times after Rhizoma Ginseng 200-334 gram is rinsed well; extraction time was respectively three hours; two hours and one hour; make it to concentrate and become paste; it is carried out drying thereupon; baking temperature is 60-80 ℃; again it is ground into 80-100 purpose Rhizoma Ginseng and extracts powder; Radix Astragali crude polysaccharides 1300-2000 gram is made into 80-100 purpose Radix Astragali crude polysaccharide powder through pulverizing; getting above-mentioned Rhizoma Ginseng extracts powder and Radix Astragali crude polysaccharide powder and puts into mixer in the lump and mix; dislocation carries out granulate in granulation machine thereupon; be made into 10-12 purpose primordial QI reinforcing electuary; pack into after drying again in 1000 bags; every bag ten gram, its baking temperature is 80-100 ℃.
Owing to adopt such scheme; prove through clinical trial; effectiveness with qi and blood tonifying; prove that by perspective study medication 1-2 is after individual month; patient's cellular immune function is obviously improved; T suppresses (Ts) delicate ratio shared in the T total cellular score and obviously descends; macrophage function and E---Flos Rosae Rugosae formation rate is significantly increased; delayed hypersensitive reaction is also had some improvement; can make the too much Ts cell of patients with advanced cancer be subjected to certain inhibition; has the human body immunity improving function; in radiotherapy; the function of protection bone marrow and the effect that primordial QI reinforcing helps unit are arranged in the chemotherapy process; antagonist generates also obvious facilitation, can be used as clinical biological response modifier (seeing the following form).The clinical tumor patient takes primordial QI reinforcing electuary front and back cellular immune function situation of change
| Immune indexes | Before the medication | After the medication | ????P |
| E phagocyte phagocytic rate E-Flos Rosae Rugosae formation rate T-cell mass (%) T3 T4 T8 | ??31.5±19.8 ??38.6±15.5 ? ??56.6±7.1 ??38.9±5.5 ??40.6±11.7 | ???40.8±21.1 ???49.1±12.3 ? ???56.8±11.9 ???35.8±7.7 ???35.8±9.6 | ??＜0.001 ??＜0.001 ? ??＞0.05 ??＞0.05 ??＞0.05 |
The P value is probability intermediate value between two groups before the medication and after the medication
In addition, take medicines such as batilol, leucogen when tumor patient after, sharply descend for avoiding leukocyte count, can take the primordial QI reinforcing electuary simultaneously, the leukopenia rate only is 18.5%.It has certain protection and raising effect to the leukocyte of patient in radiation and chemotherapy, and the present invention has changed the conventional practice that Rhizoma Ginseng can not be used as medicine, and it can be turned waste into wealth, for the mankind benefit.
The present invention will be further described below in conjunction with embodiment.
Rhizoma Ginseng 200-334 gram is removed crude removal; putting into the extraction pot water after rinsing well extracts three times repeatedly; extraction time was respectively three hours; two hours and one hour; make it to concentrate and become paste; place ebullated dryer to carry out drying thereupon; baking temperature is 60-80 ℃; dislocation is ground into 80-100 purpose Rhizoma Ginseng and extracts powder in pulverizer then, Radix Astragali crude polysaccharides 1300-2000 gram is placed be made into 80-100 purpose Radix Astragali crude polysaccharide powder in the pulverizer, gets above-mentioned Rhizoma Ginseng and extracts powder and Radix Astragali crude polysaccharides sugar and put into mixer in the lump and mix; dislocation is granulated in granulation machine thereupon; be made into 10-12 purpose primordial QI reinforcing electuary, again after the ebullated dryer drying, in 1000 bags of packing into; every bag heavy 10 gram; its baking temperature is 80-100 ℃, using method, twice of every day; each one bag, oral.
After Rhizoma Ginseng 20-33.4 gram removed crude removal and clean up; put into ebullated dryer and carry out drying; baking temperature is 60-80 ℃; dislocation is ground into 80-100 purpose Rhizoma Ginseng fecula in pulverizer then; get above-mentioned Rhizoma Ginseng fecula; Radix Astragali crude polysaccharides 130-200 gram and adjuvant precipitated calcium carbonate place in the mixer; mix; and modulate with the ethanol of 70-80%; the ethanol consumption of adjuvant precipitated calcium carbonate and 70-80% can be selected voluntarily because of the sliminess of material; dislocation is made into 100-120 purpose granule in granulation machine thereupon; hang sugar through tablet machine tabletting and sugar coating machine successively again; be made into 1000, every heavy 0.3 gram, every day three times; each 5-10 sheet, oral.
Claims (3)
1, the application of Rhizoma Ginseng and primordial QI reinforcing electuary and preparation method thereof is characterized in that: Rhizoma Ginseng has effect and the effect identical with the Radix Ginseng main root.
2; the application of Rhizoma Ginseng according to claim 1 and primordial QI reinforcing electuary and preparation method thereof; it is characterized in that: put into extraction pot water extraction three times after Rhizoma Ginseng 200-334 gram is rinsed well; extraction time was respectively three hours; two hours and one hour; make it to concentrate and become paste; it is carried out drying thereupon; baking temperature is 600-800 ℃; again it is ground into 80-100 purpose Rhizoma Ginseng and extracts powder; Radix Astragali crude polysaccharides 1300-2000 gram is made into 80-100 purpose Radix Astragali crude polysaccharide powder through pulverizing; getting above-mentioned Rhizoma Ginseng extracts powder and Radix Astragali crude polysaccharide powder and puts into mixer in the lump and mix; dislocation carries out granulate in granulation machine thereupon; be made into 10-12 purpose primordial QI reinforcing electuary; pack into after drying in 1000 bags, its baking temperature is 80-100 ℃ again.
3; Rhizoma Ginseng according to claim 1 and primordial QI reinforcing electuary and preparation method thereof; it is characterized in that: Rhizoma Ginseng 20-33.4 gram is dashed put into exsiccator after clean earlier and carry out drying; baking temperature is 60-80 ℃; dislocation is ground into 80-100 purpose Rhizoma Ginseng fecula in pulverizer then; get above-mentioned Rhizoma Ginseng fecula; Radix Astragali crude polysaccharides 130-200 gram and adjuvant precipitated calcium carbonate place in the mixer; mix; and modulate with the ethanol of 70-80%; dislocation is made into 100-120 purpose granule in granulation machine thereupon; pass through tabletting and icing again, be made into 1000.
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| CN93120971A CN1053107C (en) | 1993-12-21 | 1993-12-21 | Application of ginseng, and its vigour strengthening instant powder and prepn. method |
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| CN93120971A CN1053107C (en) | 1993-12-21 | 1993-12-21 | Application of ginseng, and its vigour strengthening instant powder and prepn. method |
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| CN1095617A true CN1095617A (en) | 1994-11-30 |
| CN1053107C CN1053107C (en) | 2000-06-07 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533612A (en) * | 2021-07-16 | 2021-10-22 | 吉林敖东药业集团延吉股份有限公司 | Detection method for controlling quality of vitality securing granules |
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1993
- 1993-12-21 CN CN93120971A patent/CN1053107C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533612A (en) * | 2021-07-16 | 2021-10-22 | 吉林敖东药业集团延吉股份有限公司 | Detection method for controlling quality of vitality securing granules |
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