CN109557052A - A kind of multiplex optical detection system and its detection method and application - Google Patents
A kind of multiplex optical detection system and its detection method and application Download PDFInfo
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- CN109557052A CN109557052A CN201910011736.1A CN201910011736A CN109557052A CN 109557052 A CN109557052 A CN 109557052A CN 201910011736 A CN201910011736 A CN 201910011736A CN 109557052 A CN109557052 A CN 109557052A
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- light source
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention provides a kind of multiplex optical detection system and its detection method and applications, including the light source generator, focusing block and light source detector being sequentially coaxially arranged, lens module is additionally provided between the light source generator and the light source detector, lens module includes the second lens for the first lens of light beam direct puncture and for converting light beam to scattered beam, the light barrier for shading is provided on second lens, the light barrier is placed in the light source receiving end of the second lens, and the light source detector is connect with signal analysis module.The beneficial effects of the present invention are embodied in: meet the inspection needs of clinical disparity items, the detection system of different principle is integrated on an instrument, change the single problem of instrument analysis performance, the situation for examining department's spaces compact is also improved simultaneously, and meets clinical different inspection demands.
Description
Technical field
The invention belongs to Protein Detection analysis technical field more particularly to a kind of multiplex optical detection system and its detection sides
Method and application.
Background technique
Specific protein analyzer is a kind of for detecting the instrument of specific protein content in sample, is usually used in clinical examination.
Usual specific protein analyzer has two kinds of detection methods of scattering and transmission, and general disc type specific protein analyzer only has one
Kind of detection method, or scattering or transmission, i.e., only a kind of Systems for optical inspection, if it is meeting different clinical examination demands,
Need the analysis instrument of more different testing principles, this not only cause the physical space of originally compact hospital laboratory occupy compared with
Greatly, and to actual work belt carry out inefficiency, it is often more important that cost can also increase therewith.
Summary of the invention
In order to solve the deficiencies in the prior art, the present invention provides a kind of multiplex optical detection system and its detection method with
Using.
The purpose of the present invention is achieved through the following technical solutions:
A kind of multiplex optical detection system, including the light source generator, focusing block and light source detector being sequentially coaxially arranged, institute
It states and is additionally provided with lens module between light source generator and the light source detector, the lens module includes being used for light beam direct puncture
The first lens and the second lens for converting light beam to scattered beam, be provided with for shading on second lens
Light barrier, the light barrier are placed in the light source receiving end of the second lens, and the light source detector is connect with signal analysis module.
Preferably, the light barrier is set to the middle part of second lens.
Preferably, the area of the light barrier accounts for the 1/5 ~ 1/3 of the second lens light source receiving end projected area.
Preferably, the light source detector includes with the transmission detector of first lens coaxial arrangement and with described the
The scatter detector of two lens coaxial arrangement.
It preferably, further include the control being electrically connected with light source generator, light source detector and the signal analysis module
Module, the control module are also connect with alarm module.
Preferably, a kind of detection method of multiplex optical detection system as described above, includes the following steps,
S1, detection project are presetting, and judge whether to match with detection method；If matching enters in next step, if mismatching,
Then start alarm module to alarm；
S2, control module control light source generator are opened, and light source detector receives the light signal of light source generator；Light source occurs
When device passes through the first lens, transmitted light beam is generated, transmission detector receives signal；If light source generator passes through the second lens,
Since straightforward beams can not penetrate baffle, scattered beam penetrates the second lens, and scatter detector receives signal；
The signal received is transmitted to signal analysis module and is further analyzed detection by S3, light source generator.
Preferably, a kind of disc type specific protein analyzer, using the multiplex optical detection system as described in any of the above is a kind of
, it further include being incubated for disk, being set to the rotating disk being incubated in disk and the reaction cup being set in rotating disk, the light source detector
Be set to it is described be incubated for disk outer ring face on, the light source generator is set in the incubation disk, and with the light source detection
Device is respectively arranged at the two sides of reaction cup.
Preferably, the bottom of the rotating disk is connect with the shaft for being incubated for disk center is set to, the shaft and driving machine
Structure connection, the driving mechanism drive shaft rotation, drives the rotating disk to rotate in the incubation disk.
Preferably, it is provided with cricoid gap between the inner wall for being incubated for disk and the outer wall of the rotating disk, between described
Gap forms the reactive tank for being used for placing response cup, and the reaction cup includes the cup body being set in reactive tank and is fixed on the rotation
Connecting rod on turntable, the rotating disk drive the reaction cup to do circumferential movement in the reactive tank.
Preferably, the bottom for being incubated for disk is provided with heating component, and the heating component is set to the reactive tank
Lower section.
The beneficial effects of the present invention are embodied in: the inspection needs of clinical disparity items are met, by the detection of different principle
The system integration changes the single problem of instrument analysis performance on an instrument, while also improving and examining department space tight
The situation gathered, and meet clinical different inspection demands.
Detailed description of the invention
Fig. 1 is attachment structure schematic diagram of the invention.
Fig. 2 is detection method flow chart of the invention.
Fig. 3 is the schematic diagram that the present invention scatters.
Fig. 4 is the structural schematic diagram for protein analyzer of the invention.
Fig. 5 is another angular views of Fig. 4.
Fig. 6 is the cross-sectional view in the direction B-B in Fig. 5.
Specific embodiment
With reference to embodiments and attached drawing is specifically described technical solution of the present invention, and present invention discloses a kind of multiplex opticals
Detection system, in conjunction with shown in Fig. 1-Fig. 3, including the light source generator, focusing block and light source detector being sequentially coaxially arranged, institute
It states and is additionally provided with lens module between light source generator and the light source detector, further include and light source generator, light source detection
The control module that device and the signal analysis module are electrically connected, the control module are also connect with alarm module.The lens
Mould group includes the second lens for the first lens of light beam direct puncture and for converting light beam to scattered beam, and described second thoroughly
The light barrier for shading is provided on mirror, the light barrier is placed in the light source receiving end of the second lens, the light source detector
It is connect with signal analysis module.The light barrier is set to the middle part of second lens, and the area of the light barrier accounts for
The 1/5 ~ 1/3 of two lens light source receiving end projected areas.The light source detector includes being coaxially disposed with first lens
Transmission detector and the scatter detector being coaxially disposed with second lens.
Present invention further teaches a kind of detection methods of multiplex optical detection system as described above, including walk as follows
Suddenly,
S1, detection project are presetting, and judge whether to match with detection method；If matching enters in next step, if mismatching,
Then start alarm module to alarm；
S2, control module control light source generator are opened, and light source detector receives the light signal of light source generator；Light source occurs
When device passes through the first lens, transmitted light beam is generated, transmission detector receives signal；If light source generator passes through the second lens,
Since straightforward beams can not penetrate baffle, scattered beam penetrates the second lens, and scatter detector receives signal；
The signal received is transmitted to signal analysis module and is further analyzed detection by S3, light source generator.
A kind of disc type specific protein analyzer applied to the above detection system in conjunction with shown in Fig. 4-Fig. 6, including is incubated for disk
1, the rotating disk 3 being incubated in disk 1 and the reaction cup 2 being set in rotating disk 3 are set to.The bottom of the rotating disk 3 and setting
It is connected in the shaft 12 for being incubated for 1 center of disk, the shaft 12 is connect with driving mechanism, 12 turns of the driving mechanism drive shaft
It is dynamic, drive the rotating disk 3 to rotate in the incubation disk 1.First bearing 10, the second axis are equipped in the shaft 12 respectively
Hold on 11, the first bearing 10, second bearing 11 outer ring be set on bearing sleeve 9.The inner wall for being incubated for disk 1 and institute
It states and is provided with cricoid gap between the outer wall of rotating disk 3, the gap forms the reactive tank 13 for being used for placing response cup, described
Reaction cup 2 includes the connecting rod 22 for being set in reactive tank 13 cup body 21 and being fixed in the rotating disk 3, the rotating disk 3
The reaction cup 2 is driven to do circumferential movement in the reactive tank 12.In order to further control rotation angle and preferably to anti-
The control for answering cup whether to detect, 3 surface of rotating disk are provided with scale 31.In this application, the focusing block is setting
In the light beam hole being incubated in disk.
Scatter detector 4 and transmission detector 5, and the scatter detector 4 are provided on the outer ring face for being incubated for disk 1
Angle is provided between the transmission detector 5.Between the scatter detector and the transmission detector angle be 20 °-
60°。
In this application, light source generator is respectively used to and the scatter detector 4 and institute for what is be arranged in the incubation disk 1
It states the corresponding scattered signal of transmission detector 5 and passes light lamp 6 and transmission signal biography light lamp 7.In the present embodiment, signal passes light lamp and is
Halogen lamp.The scattered signal passes light lamp 6 and transmission signal passes light lamp 7 and divides accordingly with scatter detector 4 and transmission detector 5
It is not set to the two sides of reaction cup 2, and is coaxially disposed with the scatter detector 4 and transmission detector 5, the scatter detector
4 and transmission detector 5 receive to pass light lamp 6 and transmission signal by the scattered signal and pass light lamp 7 respectively and be sent out across reaction cup
Optical signal.Received signal is transmitted to the control system being electrically connected by the scatter detector 4 and transmission detector 5
System, to be further analyzed.The emphasis protected not as the present invention is made a concrete analysis of, therefore details are not described herein.
Since some reaction solutions need to keep certain temperature, the bottom for being incubated for disk 1 is provided with heating component 8, institute
State the lower section that heating component 8 is set to the reactive tank 13.The heating component 8 is heater strip or heating tape, naturally it is also possible to
Using other heating modules.
The course of work of lower this application protein analyzer described briefly below:
Transmission or the selection of scattered signal lamp are carried out as needed, needed for driving reaction cup 2 to reach by shaft control rotating disk 3
Position, beam signal is received by the scatter detector 4 or transmission detector 5, and by received signal be transmitted to
Its control system being electrically connected is analyzed.
Certainly still there are many specific embodiments by the present invention, are just not listed one by one herein.It is all using equivalent replacement or
Equivalent transformation and all technical solutions formed, all fall within the scope of protection of present invention.
Claims (10)
1. a kind of multiplex optical detection system, it is characterised in that: including be sequentially coaxially arranged light source generator, focusing block and
Light source detector is additionally provided with lens module, the lens module packet between the light source generator and the light source detector
It includes for the first lens of light beam direct puncture and the second lens for converting light beam to scattered beam, is set on second lens
It is equipped with the light barrier for shading, the light barrier is placed in the light source receiving end of the second lens, the light source detector and signal
Analysis module connection.
2. a kind of multiplex optical detection system as described in claim 1, it is characterised in that: the light barrier is set to described the
The middle part of two lens.
3. a kind of multiplex optical detection system as described in claim 1, it is characterised in that: the area of the light barrier accounts for second
The 1/5 ~ 1/3 of lens light source receiving end projected area.
4. a kind of multiplex optical detection system as described in claim 1, it is characterised in that: the light source detector includes and institute
State the transmission detector of the first lens coaxial arrangement and the scatter detector with second lens coaxial arrangement.
5. a kind of multiplex optical detection system as described in claim 1, it is characterised in that: further include and light source generator, light
The control module that source detector and the signal analysis module are electrically connected, the control module are also connect with alarm module.
6. a kind of detection method of multiplex optical detection system as described in claim 1, it is characterised in that: including walking as follows
Suddenly,
S1, detection project are presetting, and judge whether to match with detection method；If matching enters in next step, if mismatching,
Then start alarm module to alarm；
S2, control module control light source generator are opened, and light source detector receives the light signal of light source generator；Light source occurs
When device passes through the first lens, transmitted light beam is generated, transmission detector receives signal；If light source generator passes through the second lens,
Since straightforward beams can not penetrate baffle, scattered beam penetrates the second lens, and scatter detector receives signal；
The signal received is transmitted to signal analysis module and is further analyzed detection by S3, light source generator.
7. a kind of disc type specific protein analyzer, it is characterised in that: application multichannel light as described in any one in claim 1-5
Detection system is learned, further includes being incubated for disk, being set to the rotating disk being incubated in disk and the reaction cup being set in rotating disk, it is described
Light source detector be set to it is described be incubated for disk outer ring face on, the light source generator is set in the incubation disk, and with institute
State the two sides that light source detector is respectively arranged at reaction cup.
8. a kind of disc type specific protein analyzer as claimed in claim 7, it is characterised in that: the bottom of the rotating disk with set
It is placed in the shaft connection for being incubated for disk center, the shaft is connect with driving mechanism, and the driving mechanism drive shaft rotation drives
The rotating disk rotates in the incubation disk.
9. a kind of disc type specific protein analyzer as claimed in claim 8, it is characterised in that: the inner wall for being incubated for disk and institute
It states and is provided with cricoid gap between the outer wall of rotating disk, the gap forms the reactive tank for being used for placing response cup, described anti-
Answering cup includes the cup body being set in reactive tank and the connecting rod that is fixed in the rotating disk, and the rotating disk drives the reaction
Cup does circumferential movement in the reactive tank.
10. a kind of disc type specific protein analyzer as claimed in claim 9, it is characterised in that: the bottom for being incubated for disk is set
It is equipped with heating component, the heating component is set to the lower section of the reactive tank.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910011736.1A CN109557052A (en) | 2019-01-07 | 2019-01-07 | A kind of multiplex optical detection system and its detection method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910011736.1A CN109557052A (en) | 2019-01-07 | 2019-01-07 | A kind of multiplex optical detection system and its detection method and application |
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| CN109557052A true CN109557052A (en) | 2019-04-02 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204101456U (en) * | 2014-06-24 | 2015-01-14 | 江苏英诺华医疗技术有限公司 | A kind of optical detection apparatus of applicable automatic clinical chemistry analyzer |
| CN104792671A (en) * | 2014-06-12 | 2015-07-22 | 南京环康电子科技有限公司 | Particle measuring device and measuring method |
| CN105784642A (en) * | 2016-05-23 | 2016-07-20 | 深圳市国赛生物技术有限公司 | Detection device and optical system thereof |
| CN205941357U (en) * | 2016-07-05 | 2017-02-08 | 上海麦棵生物科技有限公司 | Integrative optoelectronic measuring structure of scattering transmission |
| CN107003230A (en) * | 2014-09-29 | 2017-08-01 | Bd科斯特公司 | Equipment and its cuvette for the fluid sample of optical check small size |
| JP2017146226A (en) * | 2016-02-18 | 2017-08-24 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
-
2019
- 2019-01-07 CN CN201910011736.1A patent/CN109557052A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104792671A (en) * | 2014-06-12 | 2015-07-22 | 南京环康电子科技有限公司 | Particle measuring device and measuring method |
| CN204101456U (en) * | 2014-06-24 | 2015-01-14 | 江苏英诺华医疗技术有限公司 | A kind of optical detection apparatus of applicable automatic clinical chemistry analyzer |
| CN107003230A (en) * | 2014-09-29 | 2017-08-01 | Bd科斯特公司 | Equipment and its cuvette for the fluid sample of optical check small size |
| JP2017146226A (en) * | 2016-02-18 | 2017-08-24 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| CN105784642A (en) * | 2016-05-23 | 2016-07-20 | 深圳市国赛生物技术有限公司 | Detection device and optical system thereof |
| CN205941357U (en) * | 2016-07-05 | 2017-02-08 | 上海麦棵生物科技有限公司 | Integrative optoelectronic measuring structure of scattering transmission |
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