CN109512973A - A kind of medicine pill for treating chronic cough and asthma - Google Patents

A kind of medicine pill for treating chronic cough and asthma Download PDF

Info

Publication number
CN109512973A
CN109512973A CN201811534072.9A CN201811534072A CN109512973A CN 109512973 A CN109512973 A CN 109512973A CN 201811534072 A CN201811534072 A CN 201811534072A CN 109512973 A CN109512973 A CN 109512973A
Authority
CN
China
Prior art keywords
radix
asthma
lung
cough
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811534072.9A
Other languages
Chinese (zh)
Inventor
王力
付伟程
陈承
代龙革
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jingjiang Source Hubei Pharmacy Stock Co Ltd
Original Assignee
Jingjiang Source Hubei Pharmacy Stock Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jingjiang Source Hubei Pharmacy Stock Co Ltd filed Critical Jingjiang Source Hubei Pharmacy Stock Co Ltd
Priority to CN201811534072.9A priority Critical patent/CN109512973A/en
Publication of CN109512973A publication Critical patent/CN109512973A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to a kind of medicine pills for treating chronic cough and asthma, belong to Chinese herbal medicine preparation technology field.The present invention reaches sick institute with raw ephedra, ramulus cinnamomi, rhizoma pinellinae praeparata, full Snakegourd Fruit clearing lung and eliminating phlegm, laxation defaecation, inducing sweat and dispelling exogenous evils, medicine of freeinging lung and relieving asthma, and giving consideration to both the incidental and fundamental is altogether monarch drug in a prescription;Asarum, orange peel, campanulaceae, almond, perilla seed, semen brassicae, cordate houttuynia, the root bark of white mulberry, radix cynanchi atrati are ministerial drug;Stir-baked RADIX PAEONIAE ALBA, Poria cocos, the dried immature fruit of citron orange, tussilago, aster, tabasheer, radix bupleuri, Chinese yam are adjutant;Radix glycyrrhizae preparata, Radix Curcumae are to cooperate medicine and other Chinese medicines preferably to reach the effect of relieving cough and asthma of ventilatining the lung and resolving phlegm.Particle pill is made using 23 taste Chinese herbal medicines in the present invention, giving consideration to both the incidental and fundamental, simultaneously using both cold and hot drugs, Yin nourishing and lung moistening, nourishing Yin and clearing heat, beneficial lung invigorating the spleen, qi-restoratives nourishment for vitality, nourishing generate fluid, expectorant cough suppressant and anti-asthmatic, safe without toxic side effect, so that internal virus and bacteria is developed drug resistance, avoid damage to self immune system, has good curative effect to the chronic cough and asthmas disease such as bronchitis, bronchial asthma.

Description

A kind of medicine pill for treating chronic cough and asthma
Technical field
The present invention relates to a kind of medicine pills for treating chronic cough and asthma, belong to Chinese herbal medicine preparation technology field.
Background technique
Cough illness (chronic bronchitis, pulmonary emphysema, pulmonary heart disease including modern medicine, hereinafter referred to as cough illness) is a kind of Common disease, frequently-occurring disease, it is very harmful to the health of the people.Doctor trained in Western medicine lacks the method for ideal " effecting a permanent cure " to this, is mostly Based on " temporary solution ", i.e., cough-relieving given in the stage of attack of cough illness, relievingd asthma, the treatment such as anti-inflammatory, often Relapse rate is made to break out, by Year aggravates.The drug for the treatment of chronic cough and asthma is relieving cough and reducing sputum at present relievings asthma or lung power cough mixture is with expansion bronchus reduces cough Asthma, using anti-inflammatory treatments such as antibiotic such as cephalo, penicillin, pioneer, treatment cycle is long, and (once suffering from cold) is easy to recur after improvement, Again and again, it can not cure, and antibiotic is used for a long time, cause Endophytic bacteria drug resistance strong, later-stage utilization antibiotic is caused to be controlled Effect reduces when treatment, and has certain toxic side effect, adds anti-inflammatory treatment unhelpful to body to relieving asthma for a long time.Therefore, it is badly in need of A kind of medicine pill for being conducive to treat chronic cough and asthma of the treating both manifestation and root cause of disease of tonifying lung strengthening the spleen and replenishing qi.
Summary of the invention
It is an object of the present invention in view of the above shortcomings of the prior art, a kind of prepared from traditional Chinese medicines is provided and is formed, for slow The pathogenesis of property cough and asthma, it is invigorating the lung and the kidney, strengthening the spleen and reducing phlegm, relieving cough and asthma, safe without toxic side effect, reach treating both manifestation and root cause of disease purpose Treatment chronic cough and asthma medicine pill.
The technical scheme is that
A kind of medicine pill for treating chronic cough and asthma, which is characterized in that it is made of the raw material of following weight parts: (unit: part)
Raw ephedra 1-5 ramulus cinnamomi 5-15 stir-baked RADIX PAEONIAE ALBA 1-10 asarum 1-10
Rhizoma pinellinae praeparata 5-15 orange peel 7-17 Poria cocos 7-17 dried immature fruit of citron orange 4-14
Full Snakegourd Fruit 15-25 campanulaceae 7-17 radix glycyrrhizae preparata 15-25 tussilago 15-25
Chinese yam 10-20 almond 5-15 aster 10-20 perilla seed 5-15
Semen brassicae 5-15 cordate houttuynia 5-15 tabasheer 5-15 Radix Curcumae 7-17
Radix bupleuri 10-20 root bark of white mulberry 10-20 radix cynanchi atrati 10-20.
Further, the medicine pill of above-mentioned treatment chronic cough and asthma, it is made of the raw material of following weight parts: (unit: Part)
Raw ephedra 2-4 ramulus cinnamomi 8-12 stir-baked RADIX PAEONIAE ALBA 4-7 asarum 4-7
Rhizoma pinellinae praeparata 8-12 orange peel 10-14 Poria cocos 10-14 dried immature fruit of citron orange 6-12
Full Snakegourd Fruit 18-22 campanulaceae 10-14 radix glycyrrhizae preparata 18-22 tussilago 18-22
Chinese yam 12-18 almond 8-12 aster 12-18 perilla seed 8-12
Semen brassicae 8-12 cordate houttuynia 8-12 tabasheer 8-12 Radix Curcumae 10-14
Radix bupleuri 12-18 root bark of white mulberry 12-18 radix cynanchi atrati 12-18.
Further, the medicine pill of above-mentioned treatment chronic cough and asthma, it is made of the raw material of following weight parts: (unit: Part)
3 ramulus cinnamomi of raw ephedra, 10 stir-baked RADIX PAEONIAE ALBA, 5 asarum 5
10 orange peel of rhizoma pinellinae praeparata, 12 Poria cocos, 12 dried immature fruit of citron orange 9
12 radix glycyrrhizae preparata of complete 20 campanulaceae of Snakegourd Fruit, 20 tussilago 20
15 almond of Chinese yam, 10 aster, 15 perilla seed 10
10 cordate houttuynia of semen brassicae, 10 tabasheer, 10 Radix Curcumae 12
15 root bark of white mulberry of radix bupleuri, 15 radix cynanchi atrati 15.
In above-mentioned prescription, raw ephedra, ramulus cinnamomi, rhizoma pinellinae praeparata, full Snakegourd Fruit clearing lung and eliminating phlegm, the sharp wide chest of gas, moistening lung for removing phlegm, laxation is logical Just, mass dissipating and swelling eliminating, inducing sweat and dispelling exogenous evils, medicine of freeinging lung and relieving asthma reach sick institute, and giving consideration to both the incidental and fundamental is altogether monarch drug in a prescription;Asarum, orange peel, campanulaceae, almond, Perilla seed, semen brassicae, cordate houttuynia, the root bark of white mulberry, radix cynanchi atrati are clearing heat and detoxicating, eliminating the phlegm promoting the dispersing function of the lung is ministerial drug;Stir-baked RADIX PAEONIAE ALBA, Poria cocos, the dried immature fruit of citron orange, coltsfoot Flower, aster, tabasheer, radix bupleuri, Chinese yam spleen-strengtheningporridge tonifying lung are adjutant;Radix glycyrrhizae preparata, Radix Curcumae are to make medicine, strengthening the spleen and stomach, with other Chinese medicines Cooperation preferably reaches the effect of relieving cough and asthma of ventilatining the lung and resolving phlegm.
In material component of the invention, the pharmacology and drug effect of each component raw material are as follows:
Raw ephedra: warm-natured, acrid flavour, hardship;Return lung, bladder meridian;Inducing sweat and dispelling exogenous evils are freeinged lung and relieving asthma, inducing diuresis for removing edema.Chill exterior is cured mainly, Fever with aversion to cold, lossless nasal obstruction, head-body-pain, measles without adequate eruption, rubella itch;Real evil heap soil or fertilizer over and around the roots lung, cough and asthma.
Ramulus cinnamomi: acrid, sweet, warm;Return heart, lung, bladder meridian.Sweating expelling pathogenic factors from muscles and skin, warming meridian, help yang gas, flat and gas.For Anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, arthralgia, phlegm retention, oedema, palpitaition, renal mass.
Stir-baked RADIX PAEONIAE ALBA: bitter, acid, it is slightly cold;Return liver, the spleen channel.There are the effect of calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating, stir-baked RADIX PAEONIAE ALBA For headache and dizziness, hypochondriac pain, abdominal pain, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.
Asarum: it is acrid in flavour and warm in nature, it is slightly poisonous;Return heart, lung, kidney channel.Anemofrigid cold is cured mainly, is had a headache, toothache, rheumatic arthralgia, nasosinusitis, Lung cold cough.
Rhizoma pinellinae praeparata: pungent, warm;Returns spleen, stomach, lung channel.Humidifying phlegm.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, coma due to blocking of the respiratory system Headache.
Orange peel: arduous, temperature;Enter spleen, lung channel.Qi-regulating, in tune, eliminating dampness, resolving sputum.Control fullness and oppression of chest and abdomen, do not feel like eating, the vomiting sound of vomiting It is inverse, coughing with a lot of sputum.Also fish, crab poison are solved.
Poria cocos: it is sweet, light, it puts down;Return heart, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen calming heart.For edema and little urine, phlegm retention is dizzy Throb with fear, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
The dried immature fruit of citron orange: bitter, pungent, sour, temperature.Returns spleen, stomach meridian.Relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass.For internal stagnation, feeling of fullness distending pain is rushed down Weight after dysentery, constipation, phlegm stagnant gas hinder thoracic obstruction, accumulation of pathogens in chest;Gastroptosis, rectal prolapse, uterine prolapse.
Full Snakegourd Fruit: it is sweet, it trembles with fear.Return lung, stomach, large intestine channel.Clearing lung and eliminating phlegm, the sharp wide chest of gas;Moistening lung for removing phlegm, laxation defaecation, dissipating bind Detumescence.For phlegm-heat cough, thoracic obstruction, accumulation of pathogens in chest, chest diaphragm ruffian pain, dry constipation of intestines, pulmonary abscess, acute mastitis.
Campanulaceae: it is bitter, pungent, it puts down;It is distributed in lung channel.Promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest distress, pharyngalgia, Hoarse voice, lung carbuncle pyemesis, sore purulence is not at bursting.
Radix glycyrrhizae preparata: sweet and neutral;Return heart, lung, spleen, stomach meridian.Tonifying spleen stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and the stomach, burnout is weary Power, severe palpilation, knotted pulse.
Tussilago: pungent, slight bitter, temperature;It is distributed in lung channel.Moistening lung to lower qi is relieving cough and reducing sputum.It coughs for new chronic cough, dyspnea and cough with excessive sputum, overstrain cough Hemoptysis.
Chinese yam: sweet and neutral;Returns spleen, lung, kidney channel.Tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying arresting seminal emission.For spleen eating less, chronic diarrhea Incessantly, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, leukorrhagia, frequent micturition, and abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea Loose stool, leukorrhea.
Almond: bitter, temperature, it is toxic;Enter lung, large intestine channel.Expelling phlegm and arresting coughing is relievingd asthma, ease constipation.Exogenous cough is controlled, asthma is full, sore throat, Dry constipation of intestines.
Aster: pungent, bitter, temperature;It is distributed in lung channel.Moistening lung to lower qi, stopping coughing and removing phlegm.It breathes with cough for abundant expectoration, new chronic cough is coughed, overstrain cough cough Blood.
Perilla seed: acrid in flavour and warm in nature;It is distributed in lung channel.Sending down abnormally ascending dissolving phlegm, relievings asthma, ease constipation.For phlegm stops up the circulation of vital energy in the wrong direction, cough and asthma, intestinal dryness is just It is secret.
Semen brassicae: acrid flavour, it is warm-natured, it is nontoxic;Enter lung, stomach meridian.Promoting circulation of qi and eliminating phlegm, warming spleen and stomach for dispelling cold are removed obstruction in channels to relieve pain.Control phlegm retention cough Asthma, fullness in chest and hypochondrium pain, gastric disorder causing nausea vomiting, aphasia from apoplexy, limbs numbness pain is numb, tinea pedis, negative subcutaneous ulcer, pyogenic infections, treating swelling and pain by traumatic injury.
Cordate houttuynia: it is pungent, it is slightly cold;It is distributed in lung channel.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For lung carbuncle pyemesis, phlegm heat panting Cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
Tabasheer: it is sweet, it trembles with fear.Converge to heart and liver channels.Heat phlegm, cool heart arresting convulsion.For pyreticosis coma, stroke and phlegm confusing heart, children's phlegm Hot frightened epilepsy, twitch, the morbid night crying of babies.
Radix Curcumae: it is pungent, bitter, it trembles with fear;Return liver, the heart, lung channel.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.For amenorrhea and algomenorrhea, chest Abdominal distention and pain, shouting pain, pyreticosis coma, epilepsy are gone mad, jaundice and reddish urine.
Radix bupleuri: it is bitter, it is slightly cold;Return liver, gallbladder channel.It is soothing the liver in inducing diaphoresis, rising Yang.For cold, fever, fevers and chills alternate, chest side of body Distending pain, irregular menstruation, sub-official prolapses, rectal prolapse.
The root bark of white mulberry: it is sweet, it trembles with fear;It is distributed in lung channel.Removing heat from lung and relieving asthma, inducing diuresis for removing edema.For dyspnea and cough due to lung-heat, edema swelling oliguria, appearance Skin edema.
Radix cynanchi atrati: it is bitter, salty, it trembles with fear;Return stomach, liver and kidney channel.Clearing heat and cooling blood, inducing diuresis for treating strangurtia, detoxification sore treatment.For warm evil wound battalion hair Heat, fever due to yin deficiency, hectic fever due to yin labor heat, postpartum fever caused by blood deficiency, heat gonorrhea, blood strangury, swollen ulcer drug.
The beneficial effect of the present invention compared with prior art is:
Particle pill is made using 23 taste Chinese herbal medicines in the medicine pill of the treatment chronic cough and asthma, its giving consideration to both the incidental and fundamental, fever and chills are simultaneously With, Yin nourishing and lung moistening, nourishing Yin and clearing heat, beneficial lung invigorating the spleen, qi-restoratives nourishment for vitality, nourishing generate fluid, expectorant cough suppressant and anti-asthmatic, safe and non-toxic secondary work With, so that internal virus and bacteria is developed drug resistance, avoids damage to self immune system, it is slow to bronchitis, bronchial asthma etc. Property cough illness has good curative effect.
Specific embodiment
The bulk pharmaceutical chemicals in the various embodiments described above are weighed, then the 23 taste medicine such as above-mentioned raw ephedra, ramulus cinnamomi, stir-baked RADIX PAEONIAE ALBA is added Water decocts three times, and 1 hour every time, decocting liquid filtering, filtrate merged, and is concentrated into 1.10~1.20(60 DEG C of specific gravity), it is dried under reduced pressure, It crushes, adds suitable amount of sucrose powder, dextrin, dry, the medicine pill for the treatment of chronic cough and asthma is made in whole ball;It is distributed into bottle again, every bottle 50 Gram.
Usage and dosage: a bottle cap (5-8 grams) every time, three times a day, warm water takes.4 weeks as a treatment course, generally needs 4 The course for the treatment of can suitably increase and decrease the course for the treatment of according to the state of an illness.
Points for attention: pregnant woman is used with caution.
The present invention has carried out clinical observation to 180 patients, and clinical data is as follows:
1. general information
1.1 research object
In June, 2015, patient's cough and asthma history was all larger than 1 to the patient of 180 chronic cough and asthmas of outpatient service during in March, 2018 Year.It is divided into observation group and control group according to the sequence of patient assessment, every group has patient 90.Wherein control group male patient 35, female patient 55, year at age (50.5 ± 12.5), the course of disease (1.5 ± 0.4) year, observation group male patient 45, women Patient 45, in year at age (53.3 ± 8.4), in the course of disease (2 ± 0.3) year, the general information difference of two groups of patients is not after comparative analysis Significantly, therefore mutually comparing between group can be carried out, this clinical treatment patient knows and agrees to, this research approach is led to Cross ethics examination & approval.
1.2 treatment method
The patient of control group is oral by taking cephalo or woods is used for anti-inflammatory treatment, symbicort turbuhaler budesonide Formoterol again Powders for inhalation carries out treatment of relievining asthma, cephalo or again woods 1 or packet/time, 2 times/d, symbicort turbuhaler budesonide good fortune is not Each sucking is primary sooner or later for special sieve powders for inhalation;The patient of observation group takes medicine pill of the invention, and 6g/ times, 2 times/d, two groups Patient is half month treatment time.
1.3 observation item
Clinical efficacy judgement:
Cure: associated clinical symptoms completely disappear;
Improve: associated clinical symptoms are obviously improved;
Invalid: clinically relevant symptom is even aggravated without significantly improving.
The content of two groups of symptom integral evaluation mainly includes cough, asthma, abundant expectoration, each single item according to it is light, in, heavy degree It is judged as 0-3 points, score is higher, and explanation is more serious.
Record the adverse reaction occurred in two groups of therapeutic process such as vomit, diarrhea etc..
The analysis of 1.4 data
The software of data analysis is SPSS13.0, and measurement data is indicated with (mean ± standard deviation), is then used
T check analysis, enumeration data utilization rate (%) indicates, is then analyzed using Chi-square Test, the P after the comparison between group < 0.05 is significant difference.
2 results
2.1 clinical therapeutic efficacies compare
After different clinical treatments, the clinical treatment of observation group always effectively reaches 96.7%, control group 83.3%, specifically The results are shown in Table 1.
1 two groups of Clinical efficacy comparisons of table [n (%)]
2.2 pretherapy and post-treatment symptom integrals compare
The symptom for treating rear two groups of patients significantly reduces, and the effect of observation group is better than control group, the results are shown in Table 2
The pretherapy and post-treatment symptom integral of table 2 compares [X ± S points]
2.3 adverse reaction situations compare
The two groups of patient's adverse reaction rate differences that have no adverse reaction are not significant (P > 0.05).
Compared by above-mentioned clinical data, it can be found that the medicine pill of the treatment chronic cough and asthma is substantially better than conventional western medicine The therapeutic effect of " anti-inflammatory such as woods will be plus guarantor's budesonide Formoterol powders for inhalation for treatment of relievining asthma again for cephalo ".
Main case
Case 1: Chen, female, 49 years old, Gongan County pressed from both sides bamboo plantation people.Patient occur in the recent period its card cough phlegm it is few, celostomia in larynx, polydipsia Draw drink, big constipation is puckery, and skin is uninteresting.Clinical manifestation be repeated coughing, cough Huang phlegm, with dry, pharyngalgia, constipation, urine it is red, Body heat or with the symptoms such as wheeze, red tongue body, moss thin yellow or yellow greasy, Shao Jin, slippery and rapid pulse or is counted accurately.Diagnosis are as follows: xeropulmonary cough.Clothes After one course for the treatment of of medicine pill of the invention, the symptoms were significantly improved, and half a year does not recur.
Case 2: Mr. Wang, female, 38 years old, Gongan County people from Nan Ping.Symptom: more days of cough, flu of suffering from cold, nasal obstruction, anemophobia, entirely Body be stranded it is swollen, flu more after, but cough continue endlessly, phlegm lack Se Baiyi and coughs up, cough Shi Youhan.Check: tongue nature is light red, the thin string of arteries and veins, Blood cell analysis is normal, and Thoracic CT scan shows two lower pneumonia.Body temperature is slightly higher.Diagnosis: pneumonia.Take medicine pill of the invention One course for the treatment of, fever, cough symptom mitigate, continue after even served half of course for the treatment of, body complete recovery of health.Rabat is normal.
Case 3: Dong so-and-so, female 66 years old, obtains bronchial asthma 10 years and has a surplus year, meet it is cold and cool after easily violate cough, asthma, abundant expectoration, often It is secondary to use antibiotic+suppressing panting calming medicine infusion treatment 8-10 days, and suffer from cold and recur, it does not recover for a long time, uses traditional Chinese medicine pill of the invention After 4 courses for the treatment of of agent, have no that its breathing has roars of laughter ring sound, five trees, without phlegm, the state of an illness is clearly better, and has not relapsed so far.
The above is presently preferred embodiments of the present invention, and the example above explanation not make for the essence of the present invention by content Limitation in any form, technology of the person of an ordinary skill in the technical field after having read this specification according to the present invention Essence is to any simple modification or deformation made by the above specific embodiment, and the technology contents possibly also with the disclosure above The equivalent embodiment of equivalent variations is changed or is modified to, all of which are still within the scope of the technical scheme of the invention, without departing from The spirit and scope of the invention.

Claims (3)

1. a kind of medicine pill for treating chronic cough and asthma, which is characterized in that it is made of the raw material of following weight parts: (unit: Part)
Raw ephedra 1-5 ramulus cinnamomi 5-15 stir-baked RADIX PAEONIAE ALBA 1-10 asarum 1-10
Rhizoma pinellinae praeparata 5-15 orange peel 7-17 Poria cocos 7-17 dried immature fruit of citron orange 4-14
Full Snakegourd Fruit 15-25 campanulaceae 7-17 radix glycyrrhizae preparata 15-25 tussilago 15-25
Chinese yam 10-20 almond 5-15 aster 10-20 perilla seed 5-15
Semen brassicae 5-15 cordate houttuynia 5-15 tabasheer 5-15 Radix Curcumae 7-17
Radix bupleuri 10-20 root bark of white mulberry 10-20 radix cynanchi atrati 10-20;
In above-mentioned prescription, raw ephedra, ramulus cinnamomi, rhizoma pinellinae praeparata, full Snakegourd Fruit are monarch drug in a prescription;It is asarum, orange peel, campanulaceae, almond, perilla seed, white Mustard seed, cordate houttuynia, the root bark of white mulberry, radix cynanchi atrati are ministerial drug;Stir-baked RADIX PAEONIAE ALBA, Poria cocos, the dried immature fruit of citron orange, tussilago, aster, tabasheer, radix bupleuri, Chinese yam are Adjutant, radix glycyrrhizae preparata, Radix Curcumae are to make medicine, and strengthening the spleen and stomach preferably reaches relieving cough and asthma function of ventilatining the lung and resolving phlegm with the cooperation of other Chinese medicines Effect.
2. it is according to claim 1 treatment chronic cough and asthma medicine pill, which is characterized in that it by following weight parts original Material is made: (unit: part)
Raw ephedra 2-4 ramulus cinnamomi 8-12 stir-baked RADIX PAEONIAE ALBA 4-7 asarum 4-7
Rhizoma pinellinae praeparata 8-12 orange peel 10-14 Poria cocos 10-14 dried immature fruit of citron orange 6-12
Full Snakegourd Fruit 18-22 campanulaceae 10-14 radix glycyrrhizae preparata 18-22 tussilago 18-22
Chinese yam 12-18 almond 8-12 aster 12-18 perilla seed 8-12
Semen brassicae 8-12 cordate houttuynia 8-12 tabasheer 8-12 Radix Curcumae 10-14
Radix bupleuri 12-18 root bark of white mulberry 12-18 radix cynanchi atrati 12-18.
3. the medicine pill for the treatment of chronic cough and asthma according to claim 1 or 2, which is characterized in that it is by following weight parts Raw material be made: (unit: part)
3 ramulus cinnamomi of raw ephedra, 10 stir-baked RADIX PAEONIAE ALBA, 5 asarum 5
10 orange peel of rhizoma pinellinae praeparata, 12 Poria cocos, 12 dried immature fruit of citron orange 9
12 radix glycyrrhizae preparata of complete 20 campanulaceae of Snakegourd Fruit, 20 tussilago 20
15 almond of Chinese yam, 10 aster, 15 perilla seed 10
10 cordate houttuynia of semen brassicae, 10 tabasheer, 10 Radix Curcumae 12
15 root bark of white mulberry of radix bupleuri, 15 radix cynanchi atrati 15.
CN201811534072.9A 2018-12-14 2018-12-14 A kind of medicine pill for treating chronic cough and asthma Pending CN109512973A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811534072.9A CN109512973A (en) 2018-12-14 2018-12-14 A kind of medicine pill for treating chronic cough and asthma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811534072.9A CN109512973A (en) 2018-12-14 2018-12-14 A kind of medicine pill for treating chronic cough and asthma

Publications (1)

Publication Number Publication Date
CN109512973A true CN109512973A (en) 2019-03-26

Family

ID=65795667

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811534072.9A Pending CN109512973A (en) 2018-12-14 2018-12-14 A kind of medicine pill for treating chronic cough and asthma

Country Status (1)

Country Link
CN (1) CN109512973A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110898200A (en) * 2019-12-02 2020-03-24 明昌平 Medicine for treating respiratory system diseases and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107496578A (en) * 2017-08-15 2017-12-22 贵州盘州阿卡迪亚医疗管理有限公司 Treat Chinese medicine composition of chronic cough and asthma and preparation method and application
CN108079177A (en) * 2016-11-21 2018-05-29 任秀敏 A kind of Chinese medicine composition to moisten the lung and relieve the cough
CN108143818A (en) * 2016-12-05 2018-06-12 曹志亮 A kind of Chinese medicine composition for controlling cough and asthma

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108079177A (en) * 2016-11-21 2018-05-29 任秀敏 A kind of Chinese medicine composition to moisten the lung and relieve the cough
CN108143818A (en) * 2016-12-05 2018-06-12 曹志亮 A kind of Chinese medicine composition for controlling cough and asthma
CN107496578A (en) * 2017-08-15 2017-12-22 贵州盘州阿卡迪亚医疗管理有限公司 Treat Chinese medicine composition of chronic cough and asthma and preparation method and application

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
杨彩凤等: "小青龙汤加减治疗喘证的体会", 《中医药研究》 *
陈燕力: "理肺调肝法治疗哮病发作期40例", 《吉林中医药》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110898200A (en) * 2019-12-02 2020-03-24 明昌平 Medicine for treating respiratory system diseases and preparation method thereof

Similar Documents

Publication Publication Date Title
CN101601830B (en) Chinese medicinal preparation for treating cold and preparation method thereof
CN102743737B (en) Chinese medicinal preparation for effectively treating tracheitis
CN103169923B (en) Traditional Chinese medicine composition for treating myocarditis and preparation method of traditional Chinese medicine composition
CN103536889A (en) Traditional Chinese medicine decoction for treating senile chronic bronchitis complicated pulmonary emphysema
CN104491356A (en) Traditional Chinese medicine composition for treating swollen sore throat and chronic pharyngitis
CN104306766B (en) Prevent and treat Chinese medicinal formulae of patients with radioactive mucositis of oral cavity and preparation method thereof
CN102716326B (en) Medicine for enhancing immunity
CN104606580A (en) Traditional Chinese medicine preparation with synergistic effect on chemotherapy and preparation method of traditional Chinese medicine preparation traditional Chinese medicine preparation
CN101690787B (en) Traditional Chinese medicine for treating chronic gastritis and gastric ulcer
CN109512973A (en) A kind of medicine pill for treating chronic cough and asthma
CN102949695B (en) Traditional Chinese medicine for treating intractable hiccough
CN104707010A (en) Traditional Chinese medicinal composition for treating pneumonia and clearing away heat and toxic materials and preparation method thereof
CN104623612A (en) Drug for promoting blood circulation to remove blood stasis and treating acute mastitis and preparation method thereof
CN108815329A (en) A kind of Chinese medicine composition and preparation method thereof for treating flu
CN106511812A (en) Medicine for treating common cold and preparation method of medicine
CN100409884C (en) Chinese traditional medicine for treating cold
CN106421411A (en) Stomach tonifying functional beverage
CN106334155A (en) Traditional Chinese medicine composition for treating arterial thyromegaly and preparation method thereof
CN105250746A (en) Heat clearing and toxin removing oral liquid and preparation method thereof
CN104258361A (en) Traditional Chinese medicine composition for treating infantile asthma
CN104189870A (en) Traditional Chinese medicine for treating allergic asthma
CN103432409B (en) A kind for the treatment of is addicted to the Chinese medicine of food barbecue type axilla acute suppurative lymphadenitis
CN103239639A (en) Traditional Chinese medicine for treating anaphylactoid purpura
CN103041229A (en) Medicament for treating pthisis and manufacturing method thereof
CN109172763A (en) A kind of Chinese medicinal formulae for treating lung cancer

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20190326

RJ01 Rejection of invention patent application after publication