CN109503629A - A kind of synthetic method of Ceftizoxime acid - Google Patents
A kind of synthetic method of Ceftizoxime acid Download PDFInfo
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- CN109503629A CN109503629A CN201811641348.3A CN201811641348A CN109503629A CN 109503629 A CN109503629 A CN 109503629A CN 201811641348 A CN201811641348 A CN 201811641348A CN 109503629 A CN109503629 A CN 109503629A
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- added
- acid
- anca
- methylene chloride
- dimethylaminopyridine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
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- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
The invention discloses a kind of synthetic methods of Ceftizoxime acid, belong to medical synthesis technical field.The present invention, which is reacted using 7-ANCA with AE active ester, prepares Ceftizoxime acid.Synthetic method of the present invention is simple, reacts easy to operate, and yield and purity are higher, the few advantage of product by-product, are suitble to industrialized production.
Description
Technical field
The invention belongs to technical field of medicine synthesis, in particular to a kind of synthetic method of Ceftizoxime acid.
Background technique
Ceftizoxime acid, chemical name are as follows: (6R, 7R) -7- [(Z) -2- (2- amino -4- thiazolyl) -2- methoxyimino
Acetamido] miscellaneous two ring [4.2.0] oct-2-ene -2- carboxylic acid of -8- oxo -5- thia -1- ammonia, structural formula are as follows:
The Third generation Cephalosporins antibiotic that Ceftizoxime is developed by Japanese Fujisawa Pharmaceutical Co., Ltd earliest, in
Nineteen eighty-two lists in Japan first, trade name Ceftizox.This product is as third generation cephalosporin antibiotic, mechanism of action
For by inhibiting the biosynthesis of bacteria cell wall mucopeptide to reach bactericidal effect, there is wide spectrum, efficient, resistance to enzyme, low toxicity and energy
The characteristics of passing through blood-brain barrier.Wide spectrum beta-lactamase (including the mould that a variety of gram positive bacterias and gram-negative bacteria are generated
Plain enzyme and cephalosporinase) stablize.Have to enterobacteriaceae lactobacteriaceaes such as escherichia coli, Klebsiella Pneumoniae, proteus mirabilises
Powerful antibacterial action, the pseudomonas such as pseudomonas aeruginosa and acinetobacter are poor to this product sensibility.Ceftizoxime convection current
Haemophilus influenza and neisseria gonorrhoeae have good antibacterial action.To the effect of staphylococcus aureus and staphylococcus epidermis compared with
First, second generation cephalosporin be it is poor, methicillin-resistant staphylococcus aureus and enterococcus spp are to this product drug resistance, various hammers
Bacterium is highly sensitive to this product.The anaerobic bacterias such as peptococcus, peptostreptococcus and part Bacteroides are in sensitivity to this product more, difficult
Difficult clostridium is to this product drug resistance.Clinically for treating lower respiratory tract infection caused by sensitive bacteria, urinary tract infections, abdominal cavity infection, basin
Meningitis caused by chamber infection, septicemia, skin soft-tissue infection, bone and the infection of joint, streptococcus pneumonia or haemophilus influenzae
And Simple gonorrhea.
There are following several situations about Ceftizoxime synthesis technology report at present:
1. disclosing two lines in United States Patent (USP) US4427674, one is with 7- phenylacetyl amido -3- cephalosporin -4
Carboxylic acid is raw material to methoxybenzyl ester, is repeatedly sloughed blocking group, then ceftizoxime sodium is made with salt forming agent.This route repeatedly takes off
Base is deprotected, causes reaction step long, increases operation sequence and production cost.Another is with 7- amino-nothing -3- cephalo -
4- formic acid is raw material and cefotaxime acetic acid direct polycondensation, and then again at salt, the product of this road institute need to be through column chromatographic purifying, and operation is numerous
It is trivial.
2. Chinese patent CN102603771A is reported, using 7-ANCN and AE active ester as raw material, reacted at 20-40 DEG C, system
Ceftizoxime acid, but product yield and purity is not still high, while it is miscellaneous also to have the by-product that carbonyl is generated with amido bond etc.
Geological Problems do not solve.
Summary of the invention
It, should present invention aims at a kind of synthetic method of new Ceftizoxime acid in view of the deficiencies of the prior art, is provided
Synthetic method operation is simple, and yield and purity are higher, and product by-product is few, is suitble to industrialized production.
A kind of synthetic method of Ceftizoxime acid, synthesized method include the following steps:
7-ANCA, methylene chloride, acid binding agent are sequentially added into reactor and are stirred dissolution, is controlled under cryogenic,
AE active ester is added dropwise, adds within 15 minutes, adds 4-dimethylaminopyridine, keeps cryogenic conditions constant, is stirred to react a timing
Between, after reaction, at room temperature be added water be layered, organic phase is separated, retain water phase, be added methylene chloride into
Row washing, then plus active carbon decoloring, addition hydrochloric acid crystallization are centrifuged, are dried to obtain Ceftizoxime acid；
Its synthetic route is as follows:
Preferably, 7-ANCA and AE active ester are 1:1.1；Acylation reaction temperature is -5 DEG C -10 DEG C, it is further preferred that
Acylation reaction temperature is -5 DEG C -0 DEG C.
Preferably, acid binding agent used is triethylamine, n,N-diisopropylethylamine or 4-dimethylaminopyridine；Acid binding agent mole
Dosage is 2 times of 7-ANCA.
Preferably, 4-dimethylaminopyridine mole dosage is 0.5 times of 7-ANCA.
Preferably, the acylation reaction time is 3-4h.
It is further preferred that specific reaction step are as follows: sequentially add 7-ANCA, methylene chloride, 4-dimethylaminopyridine
Reactor stirring and dissolving, control are reacted at -5 DEG C -0 DEG C, and AE active ester is added dropwise, adds within 15 minutes, adds 4- dimethylamino
Pyridine is stirred to react 3-4h, after reaction, water is added at room temperature and is layered, organic phase is separated, water is retained
Phase is added methylene chloride and is washed, and then plus active carbon decoloring, addition hydrochloric acid crystallization are centrifuged, are dried to obtain Ceftizoxime
Acid.
Compared with the prior art, the beneficial effects of the present invention are:
(1) acylation reaction control is reacted under cryogenic, reduces the side reaction of carbonyl and amido bond, improves simultaneously
Total yield of products and purity.
(2) each response parameter condition is controlled in suitable ratio, while guaranteeing product yield and purity is high, also
Production cost is fallen below to minimum, suitable industrialized production.
Specific embodiment
Summary of the invention of the invention is described in further detail below by specific embodiment, but is not therefore limited
Determine the contents of the present invention.
Embodiment 1
The preparation of Ceftizoxime acid
7-ANCA 20.01g (0.1mol), methylene chloride 150ml, triethylamine 0.2mol are sequentially added reactor to carry out
Stirring and dissolving controls under the conditions of 5-10 DEG C, is added dropwise AE active ester 35.02g (0.1mol), adds within 15 minutes, add 4- bis-
Methylamino pyridine 0.05mol keeps temperature condition constant, is stirred to react 3-4h, after reaction, water is added at room temperature and carries out
Then plus active carbon decoloring layering, organic phase is separated, and retains water phase, and methylene chloride is added and is washed, and, hydrochloric acid is added
Crystallization is centrifuged, is dried to obtain Ceftizoxime acid 32.64g, product yield 85%, purity 99.5%, largest single impurity 0.06%,
Total miscellaneous 0.36%.
Embodiment 2
The preparation of Ceftizoxime acid
7-ANCA 20.02g (0.1mol), methylene chloride 150ml, 4-dimethylaminopyridine 0.2mol are sequentially added instead
It answers device to be stirred dissolution, controls under the conditions of -5-0 DEG C, be added dropwise AE active ester 38.52g (0.11mol), add within 15 minutes, then
Be added 4-dimethylaminopyridine 0.05mol, keep temperature condition it is constant, be stirred to react 3-4h, after reaction, at room temperature plus
Enter water to be layered, organic phase is separated, retain water phase, methylene chloride is added and is washed, then plus active carbon decoloring,
Hydrochloric acid crystallization is added, is centrifuged, is dried to obtain Ceftizoxime acid 37.13g, yield 97%, purity 99.8%, largest single impurity
0.05%, total miscellaneous 0.18%.
Embodiment 3
The preparation of Ceftizoxime acid
7-ANCA 20.02g (0.1mol), methylene chloride 150ml, n,N-diisopropylethylamine 0.2mol are sequentially added
Reactor is stirred dissolution, controls under the conditions of 0-5 DEG C, is added dropwise AE active ester 42.01g (0.12mol), adds within 15 minutes,
It keeps temperature condition constant, is stirred to react 3-4h, after reaction, water is added at room temperature and is layered, organic phase is carried out
Then plus active carbon decoloring separation retains water phase, and methylene chloride is added and is washed, and, hydrochloric acid crystallization, centrifugation, dry is added
To Ceftizoxime acid 30.65g, yield 80%, purity 99.7%, largest single impurity 0.07%, total miscellaneous 0.25%.
Embodiment 4
The preparation of Ceftizoxime acid
7-ANCA 20.02g (0.1mol), methylene chloride 150ml, triethylamine 0.2mol are sequentially added reactor to carry out
Stirring and dissolving controls under the conditions of 5-10 DEG C, is added dropwise AE active ester 38.52g (0.11mol), adds within 15 minutes, add 4- bis-
Methylamino pyridine 0.05mol keeps temperature condition constant, is stirred to react 3-4h, after reaction, water is added at room temperature and carries out
Then plus active carbon decoloring layering, organic phase is separated, and retains water phase, and methylene chloride is added and is washed, and, hydrochloric acid is added
Crystallization is centrifuged, is dried to obtain Ceftizoxime acid 36.48g, yield 95%, purity 99.5%, largest single impurity 0.21%, total miscellaneous
0.39%.
Claims (9)
1. a kind of synthetic method of Ceftizoxime acid, which is characterized in that the synthetic method include the following steps: by 7-ANCA,
Methylene chloride, acid binding agent sequentially add reactor and are stirred dissolution, control under cryogenic, dropwise addition AE active ester, and 15 points
Clock adds, and adds 4-dimethylaminopyridine, keeps cryogenic conditions constant, certain time is stirred to react, after reaction, in room
The warm lower water that is added is layered, and organic phase is separated, water phase is retained, methylene chloride is added and is washed, then plus active
Carbon decoloring is added hydrochloric acid crystallization, is centrifuged, is dried to obtain Ceftizoxime acid；
Its synthetic route is as follows:
2. the method according to claim 1, wherein 7-ANCA and AE active ester are 1:1.1.
3. the method according to claim 1, wherein the low temperature is -5 DEG C -10 DEG C.
4. according to the method described in claim 3, it is characterized in that, the low temperature is -5 DEG C -0 DEG C.
5. the method according to claim 1, wherein the acid binding agent is triethylamine, N, N- diisopropyl second
Amine or 4-dimethylaminopyridine.
6. the method according to claim 1, wherein the acid binding agent mole dosage is 2 times of 7-ANCA.
7. the method according to claim 1, wherein the 4-dimethylaminopyridine mole dosage is 7-ANCA
0.5 times.
8. the method according to claim 1, wherein the reaction time is 3-4h.
9. the method according to claim 1, wherein specific reaction step are as follows: by 7-ANCA, methylene chloride, 4-
Dimethylamino naphthyridine sequentially adds reactor stirring and dissolving, and control is reacted at -5 DEG C -0 DEG C, and AE active ester is added dropwise, and adds within 15 minutes
It is complete, 4-dimethylaminopyridine is added, 3-4h is stirred to react, after reaction, water is added at room temperature and is layered, it will be organic
Mutually separated, retain water phase, methylene chloride is added and is washed, then plus active carbon decoloring, be added hydrochloric acid crystallization, centrifugation,
It is dried to obtain Ceftizoxime acid.
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| CN201811641348.3A CN109503629B (en) | 2018-12-29 | 2018-12-29 | Synthesis method of ceftizoxime acid |
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| CN201811641348.3A CN109503629B (en) | 2018-12-29 | 2018-12-29 | Synthesis method of ceftizoxime acid |
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| CN109503629B CN109503629B (en) | 2021-02-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321607A (en) * | 2020-12-04 | 2021-02-05 | 苏州盛达药业有限公司 | Method for synthesizing ceftizoxime acid by one-pot method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010426A (en) * | 2010-12-02 | 2011-04-13 | 哈药集团制药总厂 | Method for preparing ceftizoxime sodium |
| CN102603771A (en) * | 2012-02-23 | 2012-07-25 | 苏州中联化学制药有限公司 | Preparation method of ceftizoxime sodium |
| CN104193766A (en) * | 2014-08-27 | 2014-12-10 | 庄妍 | Method for preparing cefetamet acid |
| CN105622634A (en) * | 2016-03-04 | 2016-06-01 | 中山福运生物科技有限公司 | Method for producing ceftizoxime acid |
-
2018
- 2018-12-29 CN CN201811641348.3A patent/CN109503629B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102010426A (en) * | 2010-12-02 | 2011-04-13 | 哈药集团制药总厂 | Method for preparing ceftizoxime sodium |
| CN102603771A (en) * | 2012-02-23 | 2012-07-25 | 苏州中联化学制药有限公司 | Preparation method of ceftizoxime sodium |
| CN104193766A (en) * | 2014-08-27 | 2014-12-10 | 庄妍 | Method for preparing cefetamet acid |
| CN105622634A (en) * | 2016-03-04 | 2016-06-01 | 中山福运生物科技有限公司 | Method for producing ceftizoxime acid |
Non-Patent Citations (1)
| Title |
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| 张凤霞等: "头孢唑肟钠的合成", 《广东药学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321607A (en) * | 2020-12-04 | 2021-02-05 | 苏州盛达药业有限公司 | Method for synthesizing ceftizoxime acid by one-pot method |
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