CN109498989A - One kind is for judging the whether effective device of stomach and intestine electro photoluminescence and its application method - Google Patents
One kind is for judging the whether effective device of stomach and intestine electro photoluminescence and its application method Download PDFInfo
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- CN109498989A CN109498989A CN201811565078.2A CN201811565078A CN109498989A CN 109498989 A CN109498989 A CN 109498989A CN 201811565078 A CN201811565078 A CN 201811565078A CN 109498989 A CN109498989 A CN 109498989A
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- intestine
- stomach
- electro photoluminescence
- electrode
- human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0507—Electrodes for the digestive system
- A61N1/0509—Stomach and intestinal electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Electrotherapy Devices (AREA)
Abstract
The present invention relates to one kind for judging the whether effective device of stomach and intestine electro photoluminescence and its application method, it is related to a kind of medical instrument, solve the problems, such as that not all diabetes and fat complication with diabetes patient adapt to electronic stimulation mode, it includes the intraluminal catheter ontology for being inserted into small intestine by human body nasal cavity to simulate stomach and intestine electro photoluminescence in advance, the intraluminal catheter is provided with stimulating electrode in its close end position for being inserted into small intestine, and electromyographic electrode, for judging that the whether effective device of stomach and intestine electro photoluminescence further includes being set to outside human body and connecting with intraluminal catheter ontology close to its end position for being inserted into small intestine to judge the whether effective external control of stomach and intestine electro photoluminescence and detection terminal to receive intestinal wall electromyography signal caused by electromyographic electrode.The present invention has the effect of prejudging diabetes by the data for simulating stomach and intestine electro photoluminescence in advance to diabetes and fat complication with diabetes patient and fat complication with diabetes patient is appropriate for Gastroenteric Electrical boosting operation.
Description
Technical field
The present invention relates to the technical fields of medical instrument, more particularly, to one kind for judging whether stomach and intestine electro photoluminescence is effective
Device and its application method.
Background technique
Diabetes and obesity are the common public health problems in the whole world, and disease incidence is just in troubling speed
It rises.Type-2 diabetes mellitus case accounts for the overwhelming majority of all diabetes, and most of type 2 diabetes patient is by obesity
Cause.The drug therapy of two kinds of diseases because side effect or lack long-term efficacy due to prospect it is not good enough.In order to solve fat and diabetes
And the problem of depositing, now, western countries and China treated using a kind of invasive surgical operation for being called gastric bypass with
Fat diabetic, but the complication rate of gastric bypass operation is very high, in addition, irreversible due to operative treatment
Property, the patient invalid to those treatments is brought very big problem by it.
Currently, being the fresh approach for diabetes and obesity, bulletin based on stomach/intestines electricity myoelectrical activity electronic stimulation
Number for CN105521561A and a kind of entitled authorization patent of invention of closed circuit small intestine electrical stimulation device of theme describes specific reality
Apply mode comprising electrical stimulation device ontology, electrical stimulation device ontology is mainly by control device, stimulator, output electrode, input
Electrode, amplifier, wireless module and power supply composition.The invention has the benefit that 1. accelerating Intestinal transit and reducing fat suction
It receives: the intestinal absorption time is reduced, faster by more nutrient transports to distal small bowel；2. postponing gastric emptying: increasing postprandial full
Swollen sense extends interval time of having meal, to reduce food-intake；3. activating the glutted neuron of maincenter, make the long-acting of small intestine electro photoluminescence
Property is protected.
Although the secretion of insulin can be promoted to decline blood glucose by implementing above-mentioned patent, to treatment diabetes and obesity
Complication with diabetes patient is highly beneficial, but in actual application, not all diabetes and fat complication with diabetes
Patient adapts to electronic stimulation mode, and patient once occurs and be not suitable with electronic stimulation mode, on the one hand due to patient
Unconformable reason, which will lead to operation, cannot generate beneficial effect, and on the other hand invalid operation will also result in patient and expend for no reason
Mint of money, there is room for improvement.
Summary of the invention
The purpose of the present invention one is to provide a kind of with by simulating in advance to diabetes and fat complication with diabetes patient
The data of stomach and intestine electro photoluminescence prejudge diabetes and fat complication with diabetes patient is appropriate for Gastroenteric Electrical boosting operation
Effect is used to judge the whether effective device of stomach and intestine electro photoluminescence.
Foregoing invention purpose of the invention has the technical scheme that
One kind is used to judge the whether effective device of stomach and intestine electro photoluminescence, including is inserted into small intestine by human body nasal cavity to simulate stomach in advance
The intraluminal catheter ontology of intestines electro photoluminescence, the intraluminal catheter ontology are several in being provided with close to its end position for being inserted into small intestine
For generate pulse signal and by intrinsic frequency electric pulse stimulation intestinal muscle to change intestines peristalsis frequency stimulating electrode,
And the electromyographic electrode of several intestinal wall myoelectricities generated for obtaining intestines peristalsis；
For judging that the whether effective device of stomach and intestine electro photoluminescence further includes being set to outside human body and with intraluminal catheter ontology close to it
The end position connection of small intestine is inserted into receive intestinal wall electromyography signal caused by electromyographic electrode to judge stomach and intestine electro photoluminescence
Whether effectively external control and detection terminal.
It, can be with by the setting of intraluminal catheter ontology, stimulating electrode and electromyographic electrode by using above-mentioned technical proposal
Realize the simulation of stomach and intestine electro photoluminescence, and the setting for controlling and detecting terminal in vitro can be based on the intestinal wall flesh that electromyographic electrode is fed back
Electric signal judges the corresponding human body if appropriate for carrying out stomach and intestine electro photoluminescence.
The present invention is further arranged to: the intraluminal catheter ontology is also set up in the end setting for being inserted into small intestine close to it
Have for obtaining intestines peristalsis in the process to reflect enteron aisle cavity pressure situation of change and feed back to external control and detection terminal
Pressure sensor.
By using above-mentioned technical proposal, external control can be convenient by the setting of pressure sensor and detection terminal obtains
The case where taking stomach and intestine electro photoluminescence simulation test lower intestinal tract cavity pressure, to judge corresponding human body if appropriate for progress stomach indirectly
Intestines electro photoluminescence operation.
The present invention is further arranged to: the quantitative range of the pressure sensor is [Isosorbide-5-Nitrae 0], and independent pressure sensor
Length range be [1,25] mm.
By using above-mentioned technical proposal, [Isosorbide-5-Nitrae 0] and pressure sensing are set by the quantitative range of pressure sensor
The setting of device length range [1,25] mm can increase it to acquisition intestines peristalsis mistake as far as possible in the case where guaranteeing cost
The detection of enteron aisle cavity pressure in journey.
The present invention is further arranged to: the communication modes between the external control and detection terminal and the electrode module
Including wire communication mode and wireless communication mode.
By using above-mentioned technical proposal, due to having controlled and having detected the communication modes between terminal and electrode module in vitro both
There is wire communication mode to have wireless communication mode again, improve external control and detection terminal and stimulating electrode, electromyographic electrode it
Between the diversity that communicates.
The purpose of the present invention two is to provide a kind of for judging the application method of the whether effective device of stomach and intestine electro photoluminescence.
It is a kind of for judging the application method of the whether effective device of stomach and intestine electro photoluminescence, it is characterised in that:
Step 1: intraluminal catheter ontology is inserted into human small intestine by human body nasal cavity；
Step 2: individually opening electromyographic electrode and pressure sensor by controlling and detecting terminal in vitro first, acquisition is not being opened
The human body basis signal in the case of stimulator electrode pulse signal is opened, human body reference signal includes external control and detects eventually
Open myoelectricity and force samples signal in end；
Step 3: restarting electromyographic electrode, pressure sensor, stimulating electrode by controlling and detecting terminal in vitro, obtain in stimulation electricity
Myoelectricity and force samples signal under polar stimulation, and and the human body basis signal in the case of stimulator electrode pulse signal is not opened
Comparative analysis, while the blood sugar concentration of human body instantly and human blood glucose concentration under normal circumstances are detected by blood sugar monitor
It is compared, to sum up whether effective to diabetes and fat complication with diabetes patient analysis prejudges Gastroenteric Electrical boosting operation.
By using above-mentioned technical proposal, realize that intraluminal catheter ontology is inserted into human body is small by the setting of step S1
Intestines are the necessary conditions of experiment, and the setting of step S2 can be obtained effectively and not open stimulator electrode pulse signal situation
Under human body basis signal, and step S3 setting can by by step S2 human body reference signal and stimulating electrode stimulate
In the case of somatic data compare, to judge the operation whether effectively to the diabetes of user before Gastroenteric Electrical boosting operation
And fat progress effectively medical treatment.
In conclusion advantageous effects of the invention are as follows: by the setting for controlling and detecting terminal, electrode module in vitro
Gastroenteric Electrical stimulation test can be simulated, and be based on being obtained effectively according to control peristalsis frequency of the intraluminal catheter ontology based on small intestine
The Gastroenteric Electrical stimulation test data taken judge corresponding user if appropriate for progress Gastroenteric Electrical stimulation test.
Detailed description of the invention
Fig. 1 is the present invention for judging the system schematic of the whether effective device of stomach and intestine electro photoluminescence.
Fig. 2 is the enlarged diagram in the portion A in Fig. 1.
Fig. 3 is the schematic diagram of external control and detection terminal.
Fig. 4 is the step schematic diagram of application method of the present invention for judging the whether effective device of stomach and intestine electro photoluminescence.
In figure, 1, intraluminal catheter ontology；2, electrode module；3, control in vitro and detection terminal；4, stimulating electrode；5, myoelectricity
Electrode；6, pressure sensor.
Specific embodiment
Below in conjunction with attached drawing, invention is further described in detail.
As shown in Figure 1, 2, a kind of for judging that the whether effective device of stomach and intestine electro photoluminescence includes being inserted by human body nasal cavity
Small intestine to simulate the intraluminal catheter ontology 1 of stomach and intestine electro photoluminescence in advance, and intraluminal catheter is in close to its end position for being inserted into small intestine
It is provided with electrode module 2, wherein electrode module 2 includes several for generating pulse signal and by intrinsic frequency electric pulse stimulation intestines
Road muscle is to change the stimulating electrode 4 and several intestinal wall fleshes generated for obtaining intestines peristalsis of intestines peristalsis frequency
The number range of the electromyographic electrode 5 of electricity, stimulating electrode 4 and electromyographic electrode 5 is that [1,5] is a.
For judging that the whether effective device of stomach and intestine electro photoluminescence further includes being set to outside human body and leaning on intraluminal catheter ontology 1
Its nearly end position connection for being inserted into small intestine is to receive intestinal wall electromyography signal caused by electromyographic electrode 5 to judge Gastroenteric Electrical
The whether effective external control of stimulation and detection terminal 3, external control and detection terminal 3 (referring specifically to Fig. 3) are by being set to
The pulse of its internal impulse generator output is controlled, and pulse width is less than 2ms, the pulse of impulse generator output herein
The mode of the preferred dipulse of mode, i.e., by way of short pulse and long pulse combination, dipulse IES can make intestines thyroid gland function
The not normal normalization of energy, and the symptom of nausea and vomiting caused by infusion pitressin can be improved, therefore the dipulse side IES proposed
Method is than being used only short pulse or long pulse but not using traditional electrical stimulation method of short pulse or long pulse more attractive simultaneously.
Further, more accurately to reflect the human body situation under stomach and intestine electro photoluminescence, intraluminal catheter is in close to its insertion
It is additionally provided with to the setting of the end of small intestine for obtaining during intestines peristalsis to reflect enteron aisle cavity pressure situation of change and anti-
It is fed to the pressure sensor 6 of external control and detection terminal 3, the quantitative range of pressure sensor 6 is a for [Isosorbide-5-Nitrae 0], and individually pressure
The length of force snesor 6 is [1,25] mm.
Communication modes between above-mentioned controlling terminal and electrode module 2 include wire communication and wireless communication mode, nothing
Line communication includes the communication modes such as WIFI, infrared ray, electromagnetic wave, but is not limited to upper type.
The above are for judging the detailed description of the whether effective device of stomach and intestine electro photoluminescence, the following are be used to judge to one kind
The detailed description of the application method of the whether effective device of stomach and intestine electro photoluminescence.
As shown in figure 4, it is a kind of for judging the application method of the whether effective device of stomach and intestine electro photoluminescence the following steps are included:
Step S1: intraluminal catheter ontology 1 is inserted into human small intestine by human body nasal cavity；Step S2: first by controlling and detecting in vitro
Terminal 3 individually opens electromyographic electrode 5 and pressure sensor 6, obtains when not opening stimulator electrode pulse signal
Human body basis signal, human body reference signal include that external control and detection terminal 3 open myoelectricity and force samples signal；Step
Rapid S3: electromyographic electrode 5, pressure sensor 6, stimulating electrode 4 are restarted by controlling and detecting terminal 3 in vitro, is obtained in stimulation electricity
The stimulation of pole 4 lower myoelectricity and force samples signal, and believe with the human body basis do not opened in the case of stimulator electrode pulse signal
Number comparative analysis, while the blood sugar concentration of human body and blood sugar for human body under normal circumstances are dense instantly by blood sugar monitor detection
Degree is compared, and to sum up analysis prejudges whether Gastroenteric Electrical boosting operation has diabetes and fat complication with diabetes patient
Effect.
The implementation principle of the present embodiment are as follows: before user needs to carry out Gastroenteric Electrical boosting operation, first by controlling in vitro
Electromyographic electrode 5 is activated individually in system and detection device and pressure sensor 6 obtains human body people under the case where non-stimulated electrode 4 acts on
The myoelectricity and force samples signal on body basis, later by issuing 4 pulse signal starting stimulating electrode 4 of stimulating electrode, to obtain
The myoelectricity and force samples signal of the human body under the effect of stimulating electrode 4 are taken, external control and detection device pass through in stimulating electrode 4
It acts on the lower myoelectricity of human body and the myoelectricity and force samples signal on force samples signal and human body basis judges corresponding people in advance
Whether body is by effective to its fat and diabetes treatment after Gastroenteric Electrical boosting operation, it should be noted that above embodiment has
There is regular hour boundary, generally at 3 to 5 days.
The embodiment of present embodiment is presently preferred embodiments of the present invention, not limits protection of the invention according to this
Range, therefore: the equivalence changes that all structures under this invention, shape, principle are done, should all be covered by protection scope of the present invention it
It is interior.
Claims (5)
1. one kind is for judging the whether effective device of stomach and intestine electro photoluminescence, which is characterized in that small including being inserted by human body nasal cavity
Intestines to simulate the intraluminal catheter ontology (1) of stomach and intestine electro photoluminescence in advance, and the intraluminal catheter ontology (1) is in being inserted into small intestine close to it
End position be provided with electrode module (2), wherein electrode module (2) includes several for generating pulse signal and by intrinsic frequency
Rate electric pulse stimulation intestinal muscle is to change the stimulating electrode (4) of intestines peristalsis frequency and several for obtain enteron aisle compacted
Dynamic and the intestinal wall myoelectricity of generation electromyographic electrode (5)；
For judge the whether effective device of stomach and intestine electro photoluminescence further include be set to outside human body and with intraluminal catheter ontology (1) it is close
Its end position connection for being inserted into small intestine is to receive intestinal wall electromyography signal caused by electromyographic electrode (5) to judge Gastroenteric Electrical
The whether effective external control of stimulation and detection terminal (3).
2. according to claim 1 for judging the whether effective device of stomach and intestine electro photoluminescence, which is characterized in that described intracavitary
Catheter body (1) is additionally provided in the end setting for being inserted into small intestine close to it for obtaining intestines peristalsis in the process to reflect intestines
Road cavity pressure situation of change and the pressure sensor (6) for feeding back to external control and detection terminal (3).
3. according to claim 2 for judging the whether effective device of stomach and intestine electro photoluminescence, which is characterized in that the pressure
The quantitative range of sensor (6) is that [Isosorbide-5-Nitrae 0] is a, and individually the length range of pressure sensor (6) is [1,25] mm.
4. according to claim 1 for judging the whether effective device of stomach and intestine electro photoluminescence, which is characterized in that described external
Communication modes between control and detection terminal (3) and the electrode module (2) include wire communication mode and wireless telecommunications
Mode.
5. a kind of for judging the application method of the whether effective device of stomach and intestine electro photoluminescence, it is characterised in that:
Step S1: intraluminal catheter ontology (1) is inserted into human small intestine by human body nasal cavity；
Step S2: individually opening electromyographic electrode (5) and pressure sensor (6) by controlling and detecting terminal (3) in vitro first,
The human body basis signal when not opening stimulator electrode pulse signal is obtained, human body reference signal includes external control
Myoelectricity and force samples signal are opened in system and detection terminal (3)；
Step S3: electromyographic electrode (5), pressure sensor (6), stimulating electrode are restarted by controlling and detecting terminal (3) in vitro
(4), the myoelectricity and force samples signal stimulated in stimulating electrode (4) is obtained, and and does not open stimulator electrode pulse signal feelings
Human body basis signal comparative analysis under condition, while the blood sugar concentration of human body and positive reason instantly are detected by blood sugar monitor
Human blood glucose concentration under condition is compared, and to sum up whether analysis prejudges Gastroenteric Electrical boosting operation to diabetes and fat conjunction
And diabetic is effective.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811565078.2A CN109498989A (en) | 2018-12-20 | 2018-12-20 | One kind is for judging the whether effective device of stomach and intestine electro photoluminescence and its application method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811565078.2A CN109498989A (en) | 2018-12-20 | 2018-12-20 | One kind is for judging the whether effective device of stomach and intestine electro photoluminescence and its application method |
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| Publication Number | Publication Date |
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| CN109498989A true CN109498989A (en) | 2019-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811565078.2A Pending CN109498989A (en) | 2018-12-20 | 2018-12-20 | One kind is for judging the whether effective device of stomach and intestine electro photoluminescence and its application method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101060884A (en) * | 2004-09-23 | 2007-10-24 | 内测公司 | Responsive gastric stimulator |
| CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
| CN102770151A (en) * | 2009-08-03 | 2012-11-07 | 因卡伯实验室有限责任公司 | Swallowable capsule and method for stimulating incretin production within the intestinal tract |
| US20140243814A1 (en) * | 2012-03-01 | 2014-08-28 | Mark D. Noar | Catheter structure and method for locating tissue in a body organ and simultaneously delivering therapy and evaluating the therapy delivered |
| CN105521561A (en) * | 2015-12-30 | 2016-04-27 | 宁波贝思转化医学研究中心有限公司 | Closed-circuit small intestine electrical stimulation device |
-
2018
- 2018-12-20 CN CN201811565078.2A patent/CN109498989A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101060884A (en) * | 2004-09-23 | 2007-10-24 | 内测公司 | Responsive gastric stimulator |
| CN102770151A (en) * | 2009-08-03 | 2012-11-07 | 因卡伯实验室有限责任公司 | Swallowable capsule and method for stimulating incretin production within the intestinal tract |
| CN102500057A (en) * | 2011-09-28 | 2012-06-20 | 上海交通大学 | Multifunctional implanted gastrointestinal electrical stimulation system |
| US20140243814A1 (en) * | 2012-03-01 | 2014-08-28 | Mark D. Noar | Catheter structure and method for locating tissue in a body organ and simultaneously delivering therapy and evaluating the therapy delivered |
| CN105521561A (en) * | 2015-12-30 | 2016-04-27 | 宁波贝思转化医学研究中心有限公司 | Closed-circuit small intestine electrical stimulation device |
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Effective date of registration: 20210917 Address after: 315000 No. 167-8, Lushan West Road, bonded South District, Ningbo City, Zhejiang Province Applicant after: MEDKINETIC Inc. Address before: 315800-23, building 1, No. 491, Mingzhou West Road, Beilun District, Ningbo City, Zhejiang Province Applicant before: NINGBO BETH TRANSLATIONAL MEDICINE RESEARCH CENTER Co.,Ltd. |
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Application publication date: 20190322 |