CN109498562B - Emergency burn care solution and preparation method thereof - Google Patents
Emergency burn care solution and preparation method thereof Download PDFInfo
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- CN109498562B CN109498562B CN201811551201.5A CN201811551201A CN109498562B CN 109498562 B CN109498562 B CN 109498562B CN 201811551201 A CN201811551201 A CN 201811551201A CN 109498562 B CN109498562 B CN 109498562B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The invention belongs to the technical field of care solutions, and particularly relates to an emergency burn care solution and a preparation method thereof. The emergency burn nursing liquid provided by the invention comprises the following components in parts by weight: 0.4-0.8 part of Australian tea tree essential oil, 0.1-0.3 part of triethanolamine, 0.4-0.4 part of tween-800.2, 0.2-0.3 part of eucommia leaf powder, 0.2-0.3 part of thickening agent, 0.1-0.5 part of emulsifier, 0.4-0.6 part of preservative and 96-100 parts of deionized water. The emergency burn care solution provided by the invention has fewer components, is simple in preparation method, can quickly achieve good sterilization and anti-inflammation effects, and has extremely obvious effect when being used for treating wounds.
Description
Technical Field
The invention belongs to the technical field of care solutions, and particularly relates to an emergency burn care solution and a preparation method thereof.
Background
Burn refers to damage to skin, mucous membrane, and even deep tissues caused by heat, chemical substances, electric energy, radiation, etc., wherein thermal burn (such as flame, boiled water, etc.) is the most common and common accidental injury in clinic. The severity of the burn depends on the extent and depth of the injured tissue, and the depth of burn can be divided into degrees I, II and III. The first degree burn injury is the least. Burned skin is red, painful, visibly tender, exuding or edematous. The injured part was partially whitened by light pressure, but no blisters were present. The second degree burn injury is deeper. Skin blisters. The blister bottom is red or white and is filled with a clear, viscous liquid. Tenderness and tenderness, and whitening when pressed. The third degree burn injury is deepest. The burned surface may be whitish, soft or black, charred leather-like. The burned skin becomes pale and is often mistaken for normal skin in people with white skin, but does not change color when pressed. The damaged red blood cells can make the skin of the burned part appear bright red, occasionally have blisters, and the hair in the burned area is easily pulled out and feels declined. The III degree burn area is generally not painful because the nerve endings of the skin are damaged.
At present, various products for treating burn, such as burn powder, burn cream, burn liquid and the like, appear on the market, and although the products can effectively treat burn, certain stimulation effect can be caused to the skin of a person if the products enter the human body, and some products even cause female menstrual disorder and damage the liver of the person, so that the development of the product which has no stimulation effect on the human body and can not damage the health of the human body is a necessary thing.
Chinese patent application CN108578425A discloses a burn ointment comprising magnesium aluminum silicate, butyl oleate, tween-80 and ethylparaben, which can rapidly relieve heat toxin of wound surface in a short period, has significant anti-inflammatory effect, short toxin liquefaction and discharge time, accelerates granulation and epithelial growth, and has flat wound healing surface and light scar. However, the burn ointment contains magnesium aluminum silicate and ethylparaben which have certain stimulation effect on human bodies.
The Chinese patent application CN108524773A discloses a burn liquid, which comprises astragalus root, dahurian angelica root, bletilla striata, coptis root, rhubarb, notoginseng, pearl yellow and the like. However, the burn lotion comprises 26 components, and also comprises some rare Chinese medicinal materials, so that the burn lotion has high cost, complicated preparation process and difficult obtainment.
Therefore, the products for treating burn in the prior art generally have the defects of strong stimulation to human bodies, high cost and complex preparation process.
Disclosure of Invention
In order to make up for the defects in the prior art, the invention aims to provide an emergency burn nursing liquid and a preparation method thereof. The emergency burn care solution provided by the invention has the advantages of no stimulation to a human body, low cost and simple preparation method.
In order to achieve the purpose, the invention adopts the technical scheme that:
an emergency burn care solution comprises the following components in parts by weight: 0.4-0.8 part of Australian tea tree essential oil, 0.1-0.3 part of triethanolamine, 0.4-0.4 part of tween-800.2, 0.2-0.3 part of eucommia leaf powder, 0.2-0.3 part of thickening agent, 0.1-0.5 part of emulsifier, 0.4-0.6 part of preservative and 96-100 parts of deionized water.
Preferably, the emergency burn nursing liquid consists of the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water.
Preferably, the thickener is carbomer resin 980;
preferably, the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 6-9: 1-3: 2-4;
more preferably, the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition;
preferably, the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 13-15: 4-6;
more preferably, the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The invention also provides a preparation method of the emergency burn care solution, which comprises the following operation steps:
s1, adding a thickening agent and an emulsifying agent into deionized water, soaking for 0.5-1.5h, slowly stirring while heating to 80-90 ℃, and stirring for 5-15min until the mixture is uniformly mixed to obtain a mixture I;
s2, cooling the mixture I obtained in the step S1 to 55-65 ℃, adding triethanolamine, and slowly stirring for 10-20min until uniformly mixing to obtain a mixture II;
s3, cooling the mixture II obtained in the step S2 to 35-45 ℃, adding Australian tea tree essential oil, eucommia ulmoides leaf powder, a preservative and Tween-80, and slowly stirring for 15-25min until uniformly mixing to obtain a mixture III;
and S4, discharging after the mixture III obtained in the step S3 is detected to be qualified, and obtaining the product.
Preferably, the slow stirring rotation speed in the steps S1, S2 and S3 is 50-100 r/min.
The Australian tea tree essential oil is extracted from Australian tea trees, is colorless and transparent, has extremely low viscosity, can make brains clear and revive, has no stimulation to skins, and also has remarkable bacteriostatic acne-removing effects; folium Eucommiae powder is prepared by pulverizing dried folium Eucommiae of Eucommiaceae, has mild pungent and warm nature, and has effects in nourishing liver and kidney, lowering blood pressure, and strengthening tendons and bones. The invention unexpectedly discovers that the Australian tea tree essential oil and the eucommia leaf powder are mixed according to a certain proportion for use, so that the healing of burned skin can be accelerated, the proliferation of cells is promoted, and the skin can quickly recover to be smooth and fine, and moreover, a proper amount of Tween-80 is added in the invention, and the Tween-80 is dissolved in water to play a certain role in helping dissolution, so that the Australian tea tree essential oil and the eucommia leaf powder can be quickly dissolved in the water, and the time for preparing the emergency burn care solution is greatly saved.
In addition, the thickening agent used in the method is carbomer resin 980, has good gelling property, adhesiveness and film forming property, greatly improves the utilization rate of Australian tea tree essential oil and eucommia leaf powder, and avoids the loss of effective components; the preservative and the emulsifier used in the invention are prepared from natural substances, do not contain any irritant substance, and do not produce irritation to human bodies.
Compared with the prior art, the emergency burn care solution provided by the invention has the advantages that:
(1) the emergency burn care solution provided by the invention is simple in composition, free of stimulation to human bodies, easy to obtain and low in cost;
(2) according to the emergency burn care solution provided by the invention, the Australia tea tree essential oil and the eucommia ulmoides leaf powder are added, so that the healing time of burned skin is greatly shortened;
(3) the emergency burn care solution provided by the invention adopts carbomer resin 980 as a thickening agent, so that the utilization rate of active ingredients is greatly improved.
Detailed Description
The present invention is further explained with reference to the following specific examples, but it should be noted that the following examples are only illustrative of the present invention and should not be construed as limiting the present invention, and all technical solutions similar or equivalent to the present invention are within the scope of the present invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are commercially available products.
Australian tea tree essential oil is available from Guangzhou gallop Zhi trade, Inc.; folium Eucommiae powder is available from Shandong Baishi agriculture biology Co Ltd; carbomer resin 980 is available from luobu special chemical (shanghai) ltd; triethanolamine is available from the dow chemical (china) ltd; GC-04 preservative is available from Qin Ying refining chemical company, Inc., Guangzhou city; c12-20 alkylglucoside is available from Baihabo chemical Co., Ltd, Shanghai.
Example 1 an Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.4 part of Australian tea tree essential oil, 0.1 part of triethanolamine, 0.2 part of tween-800.2 part of eucommia leaf powder, 0.2 part of thickening agent, 0.1 part of emulsifier, 0.4 part of preservative and 96 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 6: 1: 2, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 13: 4.
The preparation method of the emergency burn care solution comprises the following steps:
s1, adding a thickening agent and an emulsifying agent into deionized water, soaking for 0.5h, stirring at the speed of 50r/min, gradually heating to 80 ℃, and stirring for 5min until the mixture is uniformly mixed to obtain a mixture I;
s2, cooling the mixture I obtained in the step S1 to 55 ℃, adding triethanolamine, and stirring at the speed of 50r/min for 10min until the mixture is uniformly mixed to obtain a mixture II;
s3, cooling the mixture II obtained in the step S2 to 35 ℃, adding Australian tea tree essential oil, eucommia ulmoides leaf powder, a preservative and Tween-80, and stirring at the speed of 50r/min for 15min until the mixture is uniformly mixed to obtain a mixture III;
and S4, taking the mixture III obtained in the step S3 as a sample, detecting, and discharging after the detection is qualified to obtain the product.
Example 2 an Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.8 part of Australian tea tree essential oil, 0.3 part of triethanolamine, 0.3 part of tween-800.4 part of eucommia leaf powder, 0.3 part of thickening agent, 0.5 part of emulsifier, 0.6 part of preservative and 100 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 9: 3: 4, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 15: 6.
The preparation method of the emergency burn care solution comprises the following steps:
s1, adding a thickening agent and an emulsifying agent into deionized water, soaking for 1.5h, stirring at the speed of 100r/min, gradually heating to 90 ℃, and stirring for 15min until the mixture is uniformly mixed to obtain a mixture I;
s2, cooling the mixture I obtained in the step S1 to 65 ℃, adding triethanolamine, and stirring at the speed of 100r/min for 20min until the mixture is uniformly mixed to obtain a mixture II;
s3, cooling the mixture II obtained in the step S2 to 45 ℃, adding Australian tea tree essential oil, eucommia ulmoides leaf powder, a preservative and Tween-80, and stirring at the speed of 100r/min for 25min until the mixture is uniformly mixed to obtain a mixture III;
and S4, taking the mixture III obtained in the step S3 as a sample, detecting, and discharging after the detection is qualified to obtain the product.
Example 3 an Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The preparation method of the emergency burn care solution comprises the following steps:
s1, adding a thickening agent and an emulsifying agent into deionized water, soaking for 1.0h, stirring at the speed of 75r/min, gradually heating to 85 ℃, and stirring for 10min until the mixture is uniformly mixed to obtain a mixture I;
s2, cooling the mixture I obtained in the step S1 to 60 ℃, adding triethanolamine, and stirring at the speed of 75r/min for 15min until the mixture is uniformly mixed to obtain a mixture II;
s3, cooling the mixture II obtained in the step S2 to 40 ℃, adding Australian tea tree essential oil, eucommia ulmoides leaf powder, a preservative and Tween-80, and stirring at the speed of 75r/min for 20min until the mixture is uniformly mixed to obtain a mixture III;
and S4, taking the mixture III obtained in the step S3 as a sample, detecting, and discharging after the detection is qualified to obtain the product.
Comparative example 1 Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.22 part of triethanolamine, 0.85 part of eucommia leaf powder, 0.78 part of tween-800.3 part of thickener, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that no Australian tea Tree essential oil is included in comparative example 1.
Comparative example 2 Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.85 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 800.3 parts of tween-800.3 parts, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that comparative example 2 does not contain powdered eucommia ulmoides leaves.
Comparative example 3 Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickening agent is xanthan gum; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that the thickener in comparative example 3 is xanthan gum.
Comparative example 4 an Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 1: 1: 1, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that the emulsifier in comparative example 4 consists of C12-20 alkyl glucoside, sorbitan monostearate and sucrose cocoate in a weight ratio of 1: 1: 1.
Comparative example 5 Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is C12-20 alkyl glucoside; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that the emulsifier in comparative example 5 is C12-20 alkyl glucoside.
Comparative example 6 Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 1: 1.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that the preservative in comparative example 6 consists of GC-04 preservative and imidazolidinyl urea in a weight ratio of 1: 1.
Comparative example 7 Emergency burn Care solution
The emergency burn care solution comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 7: 2: 3, preparing a composition; the preservative is GC-04 preservative.
The preparation method of the emergency burn care solution is similar to that of example 3;
the difference from example 3 is that the preservative in comparative example 7 is a GC-04 preservative.
Test example 1 irritation test
1. Test samples: the emergency burn treatment liquids prepared in examples 1 to 3 and comparative examples 1 to 7.
2. Test subjects: the irritativeness of the treatment solutions for emergency burns obtained in examples 1 to 3 and comparative examples 1 to 7 was examined by using mice as the subjects.
3. The test method comprises the following steps: before the test, the hair on the two sides of the back spine of the mouse is scraped off without damaging the skin of the mouse, and the hair removal range is 2cm multiplied by 2 cm. 1g of the test sample was applied to one side of the skin with an area of 1.5cm × 1.5cm, covered with two layers of gauze and a layer of cellophane, and fixed with medical tape, and the other side of the skin was treated the same as a blank control. Changes in both sides of the skin were observed at 24h, 48h, respectively.
4. And (3) test results: the final results show that the skin of the mice coated with the test sample has no obvious difference from the skin of the mice not coated with the test sample, which indicates that the emergency burn care solution prepared in the examples 1-3 and the emergency burn care solution prepared in the comparative examples 1-7 provided by the invention have no irritation to the skin.
Test example 2 stability test
1. Test samples: the emergency burn treatment liquids prepared in examples 1 to 3 and comparative examples 3 to 5.
2. The test method comprises the following steps:
the emergency burn care solutions prepared in examples 1 to 3 and comparative examples 3 to 5 were subjected to stability analysis:
and (3) heat resistance test: placing the emergency burn care solution prepared in the examples 1-3 and the comparative examples 3-5 in an environment of 40 ℃, standing for 90 days, and observing;
cold resistance test: placing the emergency burn care solution prepared in the examples 1-3 and the comparative examples 3-5 in an environment with the temperature of-10 ℃, standing for 90 days, and observing;
and (3) cycle testing: placing the emergency burn care solution prepared in the examples 1-3 and the comparative examples 3-5 in an environment of 40 ℃, and standing for 12 h; then placing the emergency burn care solution prepared in the examples 1-3 and the comparative examples 3-5 in an environment with the temperature of-10 ℃; this cycle was repeated three times in succession;
3. the test method comprises the following steps: the specific test results are shown in table 1.
TABLE 1 stability of the different test samples
As can be seen from table 1, the emergency burn care solutions prepared in examples 1 to 3 and comparative examples 3 to 5 have stable product performance, the eucommia ulmoides leaf powder and the australian tea tree essential oil cannot be separated out, while the technical solutions of comparative examples 3 to 5 lack components or the addition range of the components exceeds, the mutual matching among the components is affected, and the product stability is reduced, which indicates that the components of the emergency burn care solution of the invention are all absent, have synergistic effect, and the emergency burn care solution prepared by a specific production process has good stability.
Test example 3 functional test
1. Test samples: the emergency burn treatment liquids prepared in examples 1 to 3 and comparative examples 1 to 7.
2. Test subjects: 210 Kunming mice are selected, sex is not limited, weight is 18-22g, the Kunming mice are randomly divided into 11 groups, 20 mice in each group are not fasted and are not forbidden to be watered before the test, the back of the Kunming mice is depilated by barium sulfide without anesthesia, and the animals are divided into an experimental group and a control group.
3. The test method comprises the following steps:
and (3) injury treatment: adjusting temperature to 75 deg.C with circular electrocautery, directly contacting with depilated skin on back for 10s, and making into I degree burn model with 4% of body surface area.
And (3) curing treatment: respectively smearing the mice of a test group with the emergency burn care solution prepared in the examples 1-3 and the comparative examples 1-7, respectively using the emergency burn care solution once in the morning and at night every day until the burned skin is cured, if the emergency burn care solution is continuously used for 3 days, still having no obvious improvement, and recording the average time and cure rate of the volunteers for burn cure according to the ineffectiveness of the emergency burn care solution; the control mice were not coated with any product and healed naturally.
4. And (3) test results: the specific test results are shown in Table 2.
TABLE 2 healing efficacy of different test samples on burns
As can be seen from table 2, the emergency burn nursing liquid prepared in examples 1-3 of the present invention has a good therapeutic effect on the level I burn, and particularly in example 3, the healing time is only 28 hours, and the patient with the level I burn can be completely healed, so example 3 is the best example of the present invention. In comparative examples 1 to 7, the Australian tea tree essential oil and the eucommia ulmoides leaf powder are respectively removed in comparative example 1 and comparative example 2, so that the cure time is remarkably longer than that of other comparative examples, the cure rate is not high, the synergistic effect of the eucommia ulmoides leaf powder and the Australian tea tree essential oil is further highlighted, and the selection of the thickening agent, the emulsifying agent and the preservative has great influence on the effect of treating the burn according to the cure time and the cure rate results of each group in the comparative examples.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. The emergency burn care solution is characterized by comprising the following components in parts by weight: 0.4-0.8 part of Australian tea tree essential oil, 0.1-0.3 part of triethanolamine, 0.4-0.4 part of tween-800.2, 0.2-0.3 part of eucommia leaf powder, 0.2-0.3 part of thickening agent, 0.1-0.5 part of emulsifier, 0.4-0.6 part of preservative and 96-100 parts of deionized water; the thickener is carbomer resin 980; the emulsifier is prepared from C12-20 alkyl glucoside, sorbitan monostearate and sucrose-cocoate in a weight ratio of 6-9: 1-3: 2-4; the preservative is prepared from GC-04 preservative and imidazolidinyl urea in a weight ratio of 13-15: 4-6.
2. The emergency burn care solution of claim 1, which comprises the following components in parts by weight: 0.6 part of Australian tea tree essential oil, 0.22 part of triethanolamine, 0.25 part of tween-800.3 part of eucommia leaf powder, 0.25 part of thickening agent, 0.3 part of emulsifier, 0.5 part of preservative and 98 parts of deionized water.
3. The emergency burn care solution of claim 1, wherein the emulsifier is a mixture of C12-20 alkyl glucoside, sorbitan monostearate, and sucrose cocoate in a weight ratio of 7: 2: 3, and (3).
4. The emergency burn care solution of claim 1 wherein the preservative is comprised of GC-04 preservative and imidazolidinyl urea in a weight ratio of 14: 5.
5. A method for preparing an emergency burn treatment solution according to any one of claims 1 to 4, comprising the following steps:
s1, adding a thickening agent and an emulsifying agent into deionized water, soaking for 0.5-1.5h, slowly stirring while heating to 80-90 ℃, and stirring for 5-15min until the mixture is uniformly mixed to obtain a mixture I;
s2, cooling the mixture I obtained in the step S1 to 55-65 ℃, adding triethanolamine, and slowly stirring for 10-20min until uniformly mixing to obtain a mixture II;
s3, cooling the mixture II obtained in the step S2 to 35-45 ℃, adding Australian tea tree essential oil, eucommia ulmoides leaf powder, a preservative and Tween-80, and slowly stirring for 15-25min until uniformly mixing to obtain a mixture III;
and S4, discharging after the mixture III obtained in the step S3 is detected to be qualified, and obtaining the product.
6. The method for preparing an emergency burn care solution according to claim 5, wherein the slow stirring rotation speed in the steps S1, S2 and S3 is 50-100 r/min.
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| CA2532730C (en) * | 2003-07-17 | 2013-02-26 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof |
| CN101199772A (en) * | 2007-12-21 | 2008-06-18 | 北京中科雍和医药技术有限公司 | Compound essential oil for treating burn, scald |
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| CN104740226A (en) * | 2015-04-07 | 2015-07-01 | 范永启 | Compound tea tree essential oil for treating slight burns and scalds |
| CN104758657A (en) * | 2015-04-17 | 2015-07-08 | 肖建农 | Traditional Chinese medicine composition for promoting healing of burn wounds and preparation method of Traditional Chinese medicine composition |
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