CN109481845A - A kind of method and relevant apparatus of the transcranial magnetic stimulation acting on Different brain region - Google Patents
A kind of method and relevant apparatus of the transcranial magnetic stimulation acting on Different brain region Download PDFInfo
- Publication number
- CN109481845A CN109481845A CN201811625440.0A CN201811625440A CN109481845A CN 109481845 A CN109481845 A CN 109481845A CN 201811625440 A CN201811625440 A CN 201811625440A CN 109481845 A CN109481845 A CN 109481845A
- Authority
- CN
- China
- Prior art keywords
- magnetic stimulation
- stimulation
- cerebral
- coil
- transcranial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
This application discloses the methods and relevant apparatus of a kind of transcranial magnetic stimulation for acting on Different brain region, it include: that magnetic stimulation system receives the positioning instruction that positioning system is sent, wherein, the positioning instruction carries the first location information of the first brain area and the second location information of the second brain area；The determining second location information with the first location information of matched first cerebral magnetic stimulation coil of first location information and with matched second cerebral magnetic stimulation coil of second location information of the magnetic stimulation system；The magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil to act on first brain area；After being spaced the first preset period of time, the magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil to act on second brain area.Implement the embodiment of the present invention, is conducive to abundant application scenarios.
Description
Technical field
The present invention relates to field of computer technology more particularly to a kind of methods for the transcranial magnetic stimulation for acting on Different brain region
And relevant apparatus.
Background technique
Studying brain dynamic duty mechanism using noninvasive Neural stem cell and changing and improving brain function is brain section in recent years
Learn the hot issue of research.Transcranial magnetic stimulation (Transcranial Magnetic Stimulation, TMS) is to pass through height
Bulky capacitor instantaneous discharge is pressed to generate changing magnetic field, realizing across skull stimulates the non-intrusion type of brain tissue, reaches temporary tune
Control the excitatoty purpose of Cortical Neurons.The light current flow field that pulse transcranial magnetic stimulation TMS (sTMS) is generated can cause
The depolarising of cortex can cause the excitability of the cortex short time to inhibit, to influence behavior output.
Since transcranial magnetic stimulation is a kind of non-intrusion type stimulation means that can change neuronal excitability in short-term, this for
Cortex cognition is carried out in healthy population, notices that relevant causal inference research provides extraordinary chance.
However, existing transcranial magnetic stimulation technology is stimulated just for single brain area, application scenarios are single.
Summary of the invention
The embodiment of the invention provides the methods and relevant apparatus of a kind of transcranial magnetic stimulation for acting on Different brain region, implement
The embodiment of the present invention is conducive to abundant application scenarios.
First aspect of the embodiment of the present invention provides a kind of method of transcranial magnetic stimulation for acting on Different brain region, comprising:
Magnetic stimulation system receives the positioning instruction that positioning system is sent, wherein the positioning instruction carries the first brain area
Second location information of the first location information and the second brain area；
Determining first with matched first cerebral magnetic stimulation coil of first location information of the magnetic stimulation system
Confidence breath and the second location information with matched second cerebral magnetic stimulation coil of second location information；
The magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil to act on first brain area；
After being spaced the first preset period of time, the magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil
To act on second brain area.
Second aspect of the embodiment of the present invention provides a kind of magnetic stimulation system, comprising:
Receiving module, for receiving the positioning instruction of positioning system transmission, wherein the positioning instruction carries the first brain area
The first location information and the second brain area the second location information；
Determining module, for the determining first position with matched first cerebral magnetic stimulation coil of first location information
Information and second location information with matched second cerebral magnetic stimulation coil of second location information；
First magnetic field generating module, for generating magnetic field by first cerebral magnetic stimulation coil to act on described the
One brain area；
Second magnetic field generating module, after being spaced the first preset period of time, for passing through second cerebral magnetic stimulation coil
Magnetic field is generated to act on second brain area.
As can be seen that in above-mentioned technical proposal, firstly, magnetic stimulation system receives the first brain area of carrying that positioning system is sent
The first location information and the second brain area the second location information positioning instruction, with determining matched with the first location information the
The first location information of one cerebral magnetic stimulation coil and with matched second cerebral magnetic stimulation coil of the second location information second
Location information, then, magnetic stimulation system generate magnetic field by the first cerebral magnetic stimulation coil to act on the first brain area, are being spaced
After first preset period of time, magnetic field is generated to act on the second brain area by the second cerebral magnetic stimulation coil, to realize to difference
Brain area carries out precise positioning, so that cerebral magnetic stimulation coil generates magnetic field to act on Different brain region, realizes and surveys to a cognition
The Different brain region that examination process is related to mutually does and carries out causal inference experimental verification and analysis, not only enrich application scenarios, also for
The Dynamic variation of intracerebral information provides new research method.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
It obtains other drawings based on these drawings.
Wherein:
Fig. 1 is a kind of process signal of method for the transcranial magnetic stimulation for acting on Different brain region provided in an embodiment of the present invention
Figure；
Fig. 2 is that another process for acting on the method for the transcranial magnetic stimulation of Different brain region provided in an embodiment of the present invention is shown
It is intended to；
Fig. 3 is a kind of schematic diagram for magnetic stimulation system that one embodiment of the present of invention provides.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
It is described in detail separately below.
Description and claims of this specification and the term " first " in above-mentioned attached drawing, " second " are for distinguishing not
Same object, is not use to describe a particular order.In addition, term " includes " and " having " and their any deformations, it is intended that
Non-exclusive include in covering.Such as the process, method, system, product or equipment for containing a series of steps or units do not have
It is defined in listed step or unit, but optionally further comprising the step of not listing or unit, or optionally further comprising
For the intrinsic other step or units of these process, methods, product or equipment.
Firstly, referring to Fig. 1, Fig. 1 be that one embodiment of the present of invention provides it is a kind of act on Different brain region through cranium magnetic
The flow diagram of the method for stimulation.Wherein, as shown in Figure 1, one kind that one embodiment of the present of invention provides acts on difference
The method of the transcranial magnetic stimulation of brain area may include:
101, magnetic stimulation system receives the positioning instruction that positioning system is sent.
Wherein, the positioning instruction carries the first location information of the first brain area and the second location information of the second brain area.
Wherein, magnetic stimulation system for example may include capacitor and inductor.
Wherein, capacitor stores a large amount of charge, discharges in a very short period of time, and the induction coil of inductor is made to generate magnetic
, and reversed induced current is generated in intracerebral.Electric current in cortex can activate big cone neurone, cause micro- in aixs cylinder
Variation is seen, and further causes the variation of electro physiology and function.
Wherein, positioning system for example may include combine magnetic resonance imaging (magnetic resonance imaging,
MRI), the image technologies such as functional magnetic resonance imaging (functional magnetic resonance imaging, fMRI)
Neuroimaging navigation positioning system.
Wherein, the first brain area and the second brain area are a part of same transcranial magnetic stimulation main body brain.
Wherein, the first brain area is in the upstream of information transmitting, processing, and the second brain area is in the downstream of information transmitting, processing.
Wherein, the present embodiments relate to information transmitting, processing be inside same transcranial magnetic stimulation main body brain
Information transmitting and processing.
102, determining first with matched first cerebral magnetic stimulation coil of first location information of magnetic stimulation system
Confidence breath and the second location information with matched second cerebral magnetic stimulation coil of second location information.
Wherein, the first cerebral magnetic stimulation coil and the second cerebral magnetic stimulation coil are the sense of the inductor in magnetic stimulation system
Answer coil.
103, magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil to act on first brain area.
104, after being spaced the first preset period of time, magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil
To act on second brain area.
Wherein, the first preset period of time for example may include 5 milliseconds, 10 milliseconds, 15 milliseconds, 20 milliseconds or other periods.
Referring to fig. 2, Fig. 2 is a kind of transcranial magnetic stimulation for acting on Different brain region that one embodiment of the present of invention provides
The flow diagram of method.Wherein, as shown in Fig. 2, a kind of Different brain region of acting on that one embodiment of the present of invention provides
The method of transcranial magnetic stimulation may include:
201, magnetic stimulation system receives the positioning instruction that positioning system is sent.
Wherein, the positioning instruction carries the first location information of the first brain area and the second location information of the second brain area.
Wherein, magnetic stimulation system for example may include capacitor and inductor.
Wherein, capacitor stores a large amount of charge, discharges in a very short period of time, and the induction coil of inductor is made to generate magnetic
, and reversed induced current is generated in intracerebral.Electric current in cortex can activate big cone neurone, cause micro- in aixs cylinder
Variation is seen, and further causes the variation of electro physiology and function.
Wherein, positioning system for example may include combine magnetic resonance imaging (magnetic resonance imaging,
MRI), the image technologies such as functional magnetic resonance imaging (functional magnetic resonance imaging, fMRI)
Neuroimaging navigation positioning system.
Wherein, the first brain area and the second brain area are a part of same transcranial magnetic stimulation main body brain.
Wherein, the first brain area is in the upstream of information transmitting, processing, and the second brain area is in the downstream of information transmitting, processing.
Wherein, the present embodiments relate to information transmitting, processing be inside same transcranial magnetic stimulation main body brain
Information transmitting and processing.
202, determining first with matched first cerebral magnetic stimulation coil of first location information of magnetic stimulation system
Confidence breath and the second location information with matched second cerebral magnetic stimulation coil of second location information.
Wherein, the first cerebral magnetic stimulation coil and the second cerebral magnetic stimulation coil are the sense of the inductor in magnetic stimulation system
Answer coil.
203, magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil to act on first brain area.
Optionally, in a first aspect, the magnetic stimulation system includes capacitor in a kind of possible embodiment of the invention
Device, the magnetic stimulation system generate magnetic field by first cerebral magnetic stimulation coil to act on first brain area, comprising:
The magnetic stimulation system discharges the charge of the capacitor storage to form electric current；
When the electric current is by first cerebral magnetic stimulation coil, the magnetic stimulation system is by described first through cranium
Magnetic stimulating coil generates magnetic field, to carry out excitability inhibition to first brain area using pulse stimulus modality.
As can be seen that the charge of magnetic stimulation system releasing capacitor storage is connect in above-mentioned technical proposal with forming electric current
, when electric current passes through the first cerebral magnetic stimulation coil, magnetic stimulation system generates magnetic field by the first cerebral magnetic stimulation coil, with
Excitability inhibition is carried out to the first brain area using pulse stimulus modality, transcranial magnetic stimulation is carried out to same brain area to realize,
And the excitability of same brain area is caused to inhibit, to realize the influence transmitted and processed to upstream information, and then influence through cranium magnetic
Subject behavior is stimulated to export, to obtain recognition tests output result.
Optionally, based in a first aspect, passing through institute in the electric current in the possible embodiment of the first of the invention
When stating the first cerebral magnetic stimulation coil, the magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil, to adopt
Excitability inhibition is carried out to first brain area with pulse stimulus modality, comprising:
When the electric current is by first cerebral magnetic stimulation coil, the magnetic stimulation system is by described first through cranium
Magnetic stimulating coil generates magnetic field, to use the pulse stimulus modality to first brain at interval of N number of second preset period of time
Area carries out excitability inhibition, wherein N is positive integer.
Optionally, i-th of preset period of time in N number of second preset period of time is different from the (i+ in N number of second preset period of time
1) a preset period of time, 0 < i≤N and i are positive integer.
Wherein, i for example may include 1,2,4,7,8,12 or other numerical value.
Wherein, the second preset period of time for example may include 5 milliseconds, 10 milliseconds, 15 milliseconds, 20 milliseconds or other periods.
Wherein, N for example may include 1,2,4,7,8,12 or other numerical value.
As can be seen that, when electric current passes through the first cerebral magnetic stimulation coil, magnetic stimulation system passes through in above-mentioned technical proposal
First cerebral magnetic stimulation coil generates magnetic field, to use pulse stimulus modality to the first brain at interval of N number of second preset period of time
Area carries out excitability inhibition, carries out transcranial magnetic stimulation to same brain area in different time intervals to realize, and cause the brain area
Excitability inhibit, realize verifying different time intervals be iteratively operating on same brain area to recognition tests output result influence.
Optionally, based on the possible embodiment of the first of first aspect or first aspect, at of the invention second
In possible embodiment, the method also includes:
At the generation magnetic field by first cerebral magnetic stimulation coil, system is presented to stimulation in the magnetic stimulation system
System sends picture and instruction is presented, wherein the picture presentation instruction is used to indicate the stimulation presentation system and shows for recognizing
The picture of test.
Wherein, stimulation presentation system is mainly used for that the picture of each recognition tests is presented, it is by host, a high refresh rate
Liquid crystal display (AOC G2770PF 144Hz) and psychology stimulation software (such as Matlab and Psychtoolbox is presented
Kit) composition.
As can be seen that in above-mentioned technical proposal, when generating magnetic field by first cerebral magnetic stimulation coil, Neural stem cell
System sends picture to stimulation presentation system and instruction is presented, so that stimulation presentation system shows the picture for recognition tests, from
And realize when stimulating brain area, display is used for the picture of recognition tests, and in order to which transcranial magnetic stimulation main body watches picture, output is recognized
Know test output result.
Optionally, based on the first or second of possible embodiment of first aspect or first aspect, in the present invention
The third possible embodiment in, the method also includes: the magnetic stimulation systems to send to behavior evaluating system
Transcranial magnetic stimulation END instruction, wherein the transcranial magnetic stimulation END instruction carries the identity of transcranial magnetic stimulation main body, institute
State transcranial magnetic stimulation END instruction be used to indicate the behavior evaluating system inquired from database with the identity
Matched transcranial magnetic stimulation with instructing the transcranial magnetic stimulation for carrying the transcranial magnetic stimulation result as the result is shown as a result, be sent to
The stimulation presentation system, the transcranial magnetic stimulation result carry out transcranial magnetic stimulation parameters by the behavior evaluating system
Statistics obtains, and the transcranial magnetic stimulation parameters include that the cognition of the transcranial magnetic stimulation main body after n times transcranial magnetic stimulation is surveyed
Examination output is as a result, the transcranial magnetic stimulation instructs to be used to indicate the stimulation presentation system and show as the result is shown described pierces through cranium magnetic
Swash result.
Wherein, behavior evaluating system is used for the assessment of behavior achievement.
Optionally, the analysis system of behavior achievement is mainly made of the kit based on Matlab platform development.
Wherein, kit for example may include EEG Lab.
Wherein, the assessment of behavior achievement is completed by data analysis system, the various experiment models of data analysis system major integration
The analysis of different parameters, obtains final assessment result under formula.Data analysis system includes
Wherein, database purchase key reaction time RT, accuracy Acc, subject's name Name, gender Sexual,
Age Age, left and right handedness Hand, experimental period Date etc..
As can be seen that magnetic stimulation system sends to carry to behavior evaluating system and pierce through cranium magnetic in above-mentioned technical proposal
The transcranial magnetic stimulation END instruction for swashing the identity of main body, so that behavior evaluating system is inquired from database and identity
Matched transcranial magnetic stimulation is identified as a result, then, behavior evaluating system will carry piercing through cranium magnetic for transcranial magnetic stimulation result
Swash instruction as the result is shown and be sent to stimulation presentation system, then, stimulation presentation system shows transcranial magnetic stimulation as a result, to realize
The visualization of transcranial magnetic stimulation result.
Optionally, based on the first or second or the third possible embodiment of first aspect or first aspect,
In the 4th kind of possible embodiment of the invention, the transcranial magnetic stimulation result includes:
Key reaction time, accuracy and left and right handedness.
204, after being spaced the first preset period of time, magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil
To act on second brain area.
Wherein, the first preset period of time for example may include 5 milliseconds, 10 milliseconds, 15 milliseconds, 20 milliseconds or other periods.
Optionally, in a first aspect, the magnetic stimulation system includes capacitor in a kind of possible embodiment of the invention
Device, after being spaced the first preset period of time, the magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil to make
For second brain area, comprising:
The magnetic stimulation system discharges the charge of the capacitor storage to form electric current；
When the electric current is by second cerebral magnetic stimulation coil, the magnetic stimulation system is by described second through cranium
Magnetic stimulating coil generates magnetic field, to carry out excitability inhibition to second brain area using pulse stimulus modality.
As can be seen that the charge of magnetic stimulation system releasing capacitor storage is connect in above-mentioned technical proposal with forming electric current
, when electric current passes through the second cerebral magnetic stimulation coil, magnetic stimulation system generates magnetic field by the second cerebral magnetic stimulation coil, with
Excitability inhibition is carried out to the second brain area using pulse stimulus modality, transcranial magnetic stimulation is carried out to same brain area to realize,
And the excitability of same brain area is caused to inhibit, to realize the influence transmitted and processed to downstream information, and then influence through cranium magnetic
Subject behavior is stimulated to export, to obtain recognition tests output result.
Optionally, based in a first aspect, passing through institute in the electric current in the possible embodiment of the first of the invention
When stating the second cerebral magnetic stimulation coil, the magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil, to adopt
Excitability inhibition is carried out to second brain area with the pulse stimulus modality, comprising:
When the electric current is by second cerebral magnetic stimulation coil, the magnetic stimulation system is by described second through cranium
Magnetic stimulating coil generates magnetic field, at interval of the N number of second preset period of time using the pulse stimulus modality to described the
Two brain areas carry out excitability inhibition, wherein N is positive integer.
Optionally, i-th of preset period of time in N number of second preset period of time is different from the (i+ in N number of second preset period of time
1) a preset period of time, 0 < i≤N and i are positive integer.
Wherein, i for example may include 1,2,4,7,8,12 or other numerical value.
Wherein, the second preset period of time for example may include 5 milliseconds, 10 milliseconds, 15 milliseconds, 20 milliseconds or other periods.
Wherein, N for example may include 1,2,4,7,8,12 or other numerical value.
As can be seen that, when electric current passes through the second cerebral magnetic stimulation coil, magnetic stimulation system passes through in above-mentioned technical proposal
Second cerebral magnetic stimulation coil generates magnetic field, to use pulse stimulus modality to the second brain at interval of N number of second preset period of time
Area carries out excitability inhibition, carries out transcranial magnetic stimulation to same brain area in different time intervals to realize, and cause the brain area
Excitability inhibit, realize verifying different time intervals be iteratively operating on same brain area to recognition tests output result influence.
Referring to Fig. 3, Fig. 3 is a kind of schematic diagram for magnetic stimulation system that one embodiment of the present of invention provides.Wherein, as schemed
Shown in 3, a kind of magnetic stimulation system 300 that one embodiment of the present of invention provides may include:
Receiving module 301, for receiving the positioning instruction of positioning system transmission.
Wherein, the positioning instruction carries the first location information of the first brain area and the second location information of the second brain area.
Wherein, magnetic stimulation system for example may include capacitor and inductor.
Wherein, capacitor stores a large amount of charge, discharges in a very short period of time, and the induction coil of inductor is made to generate magnetic
, and reversed induced current is generated in intracerebral.Electric current in cortex can activate big cone neurone, cause micro- in aixs cylinder
Variation is seen, and further causes the variation of electro physiology and function.
Wherein, positioning system for example may include combine magnetic resonance imaging (magnetic resonance imaging,
MRI), the image technologies such as functional magnetic resonance imaging (functional magnetic resonance imaging, fMRI)
Neuroimaging navigation positioning system.
Wherein, the first brain area and the second brain area are a part of same transcranial magnetic stimulation main body brain.
Wherein, the first brain area is in the upstream of information transmitting, processing, and the second brain area is in the downstream of information transmitting, processing.
Wherein, the present embodiments relate to information transmitting, processing be inside same transcranial magnetic stimulation main body brain
Information transmitting and processing.
Determining module 302, for determining first with matched first cerebral magnetic stimulation coil of first location information
Location information and second location information with matched second cerebral magnetic stimulation coil of second location information.
First magnetic field generating module 303, for generating magnetic field by first cerebral magnetic stimulation coil to act on
State the first brain area.
Optionally, in a first aspect, in a kind of possible embodiment of the invention, the first magnetic field generating module tool
Body is used for:
When the electric current is by first cerebral magnetic stimulation coil, generated by first cerebral magnetic stimulation coil
Magnetic field, to carry out excitability suppression to first brain area using the pulse stimulus modality at interval of N number of second preset period of time
System, wherein N is positive integer.
Optionally, i-th of preset period of time in N number of second preset period of time is different from the (i+ in N number of second preset period of time
1) a preset period of time, 0 < i≤N and i are positive integer.
Wherein, i for example may include 1,2,4,7,8,12 or other numerical value.
Wherein, the second preset period of time for example may include 5 milliseconds, 10 milliseconds, 15 milliseconds, 20 milliseconds or other periods.
Wherein, N for example may include 1,2,4,7,8,12 or other numerical value.
Optionally, based in a first aspect, the system also includes hairs in the possible embodiment of the first of the invention
Module is sent, the sending module is used to present at the generation magnetic field by first cerebral magnetic stimulation coil to stimulation
System sends picture and instruction is presented, wherein the picture presentation instruction is used to indicate the stimulation presentation system and shows for recognizing
Know the picture of test.
Wherein, stimulation presentation system is mainly used for that the picture of each recognition tests is presented, it is by host, a high refresh rate
Liquid crystal display (AOC G2770PF 144Hz) and psychology stimulation software (such as Matlab and Psychtoolbox is presented
Kit) composition.
Optionally, based on the possible embodiment of the first of first aspect or first aspect, at of the invention second
In possible embodiment, the sending module is also used to send transcranial magnetic stimulation END instruction to behavior evaluating system,
Wherein, the transcranial magnetic stimulation END instruction carries the identity of transcranial magnetic stimulation main body, and the transcranial magnetic stimulation terminates to refer to
Order is used to indicate the behavior evaluating system and inquires from database and the matched transcranial magnetic stimulation knot of the identity
The transcranial magnetic stimulation for carrying the transcranial magnetic stimulation result is instructed as the result is shown and is sent to the stimulation presentation system by fruit,
The transcranial magnetic stimulation result is counted to obtain by the behavior evaluating system to transcranial magnetic stimulation parameters, described through cranium
Neural stem cell parameter includes that the recognition tests of the transcranial magnetic stimulation main body after n times transcranial magnetic stimulation export as a result, the warp
Cranium Neural stem cell instructs as the result is shown to be used to indicate the stimulation presentation system and shows the transcranial magnetic stimulation result.
Wherein, behavior evaluating system is used for the assessment of behavior achievement.
Optionally, the analysis system of behavior achievement is mainly made of the kit based on Matlab platform development.
Wherein, kit for example may include EEG Lab.
Wherein, the assessment of behavior achievement is completed by data analysis system, the various experiment models of data analysis system major integration
The analysis of different parameters, obtains final assessment result under formula.Data analysis system includes
Wherein, database purchase key reaction time RT, accuracy Acc, subject's name Name, gender Sexual,
Age Age, left and right handedness Hand, experimental period Date etc..
Second magnetic field generating module 304, after being spaced the first preset period of time, for passing through the second transcranial magnetic stimulation line
Circle generates magnetic field to act on second brain area.
Wherein, the first preset period of time for example may include 5 milliseconds, 10 milliseconds, 15 milliseconds, 20 milliseconds or other periods.
It should be noted that for the various method embodiments described above, for simple description, therefore, it is stated as a series of
Combination of actions, but those skilled in the art should understand that, the present invention is not limited by the sequence of acts described because
According to the present invention, some steps may be performed in other sequences or simultaneously.Secondly, those skilled in the art should also know
It knows, the embodiments described in the specification are all preferred embodiments, and related actions and modules is not necessarily of the invention
It is necessary.
In the above-described embodiments, it all emphasizes particularly on different fields to the description of each embodiment, there is no the portion being described in detail in some embodiment
Point, reference can be made to the related descriptions of other embodiments.
In several embodiments provided herein, it should be understood that disclosed device, it can be by another way
It realizes.For example, the apparatus embodiments described above are merely exemplary, such as the division of the unit, it is only a kind of
Logical function partition, there may be another division manner in actual implementation, such as multiple units or components can combine or can
To be integrated into another system, or some features can be ignored or not executed.Another point, shown or discussed is mutual
Coupling, direct-coupling or communication connection can be through some interfaces, the indirect coupling or communication connection of device or unit,
It can be electrical or other forms.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.It can select some or all of unit therein according to the actual needs to realize the mesh of this embodiment scheme
's.
It, can also be in addition, the functional units in various embodiments of the present invention may be integrated into one processing unit
It is that each unit physically exists alone, can also be integrated in one unit with two or more units.Above-mentioned integrated list
Member both can take the form of hardware realization, can also realize in the form of software functional units.
If the integrated unit is realized in the form of SFU software functional unit and sells or use as independent product
When, it can store in a computer readable storage medium.Based on this understanding, technical solution of the present invention is substantially
The all or part of the part that contributes to existing technology or the technical solution can be in the form of software products in other words
It embodies, which is stored in a storage medium, including some instructions are used so that a computer
Equipment (can for personal computer, server or network equipment etc.) execute each embodiment the method for the present invention whole or
Part steps.And storage medium above-mentioned includes: that USB flash disk, read-only memory (ROM, Read-Only Memory), arbitrary access are deposited
Reservoir (RAM, Random Access Memory), mobile hard disk, magnetic or disk etc. be various to can store program code
Medium.
The above, the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although referring to before
Stating embodiment, invention is explained in detail, those skilled in the art should understand that: it still can be to preceding
Technical solution documented by each embodiment is stated to modify or equivalent replacement of some of the technical features；And these
It modifies or replaces, the range for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (10)
1. a kind of method for the transcranial magnetic stimulation for acting on Different brain region characterized by comprising
Magnetic stimulation system receives the positioning instruction that positioning system is sent, wherein the positioning instruction carries the first of the first brain area
Second location information of location information and the second brain area；
Believe the determining first position with matched first cerebral magnetic stimulation coil of first location information of the magnetic stimulation system
Breath and the second location information with matched second cerebral magnetic stimulation coil of second location information；
The magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil to act on first brain area；
After being spaced the first preset period of time, the magnetic stimulation system generates magnetic field by second cerebral magnetic stimulation coil to make
For second brain area.
2. the method according to claim 1, wherein the magnetic stimulation system includes capacitor, the Neural stem cell
System generates magnetic field by first cerebral magnetic stimulation coil to act on first brain area, comprising:
The magnetic stimulation system discharges the charge of the capacitor storage to form electric current；
When the electric current is by first cerebral magnetic stimulation coil, the magnetic stimulation system is pierced by described first through cranium magnetic
Swash coil and generate magnetic field, to carry out excitability inhibition to first brain area using pulse stimulus modality.
3. according to the method described in claim 2, it is characterized in that, passing through first cerebral magnetic stimulation coil in the electric current
When, the magnetic stimulation system generates magnetic field by first cerebral magnetic stimulation coil, to use pulse stimulus modality to institute
It states the first brain area and carries out excitability inhibition, comprising:
When the electric current is by first cerebral magnetic stimulation coil, the magnetic stimulation system is pierced by described first through cranium magnetic
Swash coil generate magnetic field, at interval of N number of second preset period of time using the pulse stimulus modality to first brain area into
Row excitability inhibits, wherein N is positive integer.
4. according to the method described in claim 3, it is characterized in that, the method also includes:
At the generation magnetic field by first cerebral magnetic stimulation coil, the magnetic stimulation system is sent out to stimulation presentation system
Send picture that instruction is presented, wherein the picture presentation instruction is used to indicate the stimulation presentation system and shows for recognition tests
Picture.
5. according to the method described in claim 3, it is characterized in that, the method also includes:
The magnetic stimulation system sends transcranial magnetic stimulation END instruction to behavior evaluating system, wherein described to pierce through cranium magnetic
Swash the identity that END instruction carries transcranial magnetic stimulation main body, the transcranial magnetic stimulation END instruction is used to indicate the behavior
Evaluating system is inquired with the matched transcranial magnetic stimulation of the identity from database as a result, described through cranium will carry
The transcranial magnetic stimulation of Neural stem cell result instructs the stimulation presentation system that is sent to as the result is shown, the transcranial magnetic stimulation result by
The behavior evaluating system is counted to obtain to transcranial magnetic stimulation parameters, and the transcranial magnetic stimulation parameters include passing through N
The recognition tests of the transcranial magnetic stimulation main body export as a result, the transcranial magnetic stimulation instructs as the result is shown after secondary transcranial magnetic stimulation
It is used to indicate the stimulation presentation system and shows the transcranial magnetic stimulation result.
6. according to the method described in claim 5, it is characterized in that, the transcranial magnetic stimulation result includes:
Key reaction time, accuracy and left and right handedness.
7. a kind of magnetic stimulation system characterized by comprising
Receiving module, for receiving the positioning instruction of positioning system transmission, wherein the positioning instruction carries the of the first brain area
Second location information of one location information and the second brain area；
Determining module, for the determining first location information with matched first cerebral magnetic stimulation coil of first location information
With the second location information with matched second cerebral magnetic stimulation coil of second location information；
First magnetic field generating module, for generating magnetic field by first cerebral magnetic stimulation coil to act on first brain
Area；
Second magnetic field generating module, after being spaced the first preset period of time, for being generated by second cerebral magnetic stimulation coil
Magnetic field is to act on second brain area.
8. system according to claim 7, which is characterized in that first magnetic field generating module is specifically used for:
When the electric current is by first cerebral magnetic stimulation coil, magnetic is generated by first cerebral magnetic stimulation coil
, to carry out excitability inhibition to first brain area using the pulse stimulus modality at interval of N number of second preset period of time,
Wherein, N is positive integer.
9. system according to claim 8, which is characterized in that the system also includes sending module, the sending module
For sending picture presentation to stimulation presentation system and referring at the generation magnetic field by first cerebral magnetic stimulation coil
It enables, wherein the picture presentation instruction is used to indicate the stimulation presentation system and shows the picture for being used for recognition tests.
10. according to the method described in claim 8, it is characterized in that, the sending module is also used to behavior achievement assessment system
System sends transcranial magnetic stimulation END instruction, wherein the transcranial magnetic stimulation END instruction carries the identity of transcranial magnetic stimulation main body
Mark, the transcranial magnetic stimulation END instruction are used to indicate the behavior evaluating system and inquire from database and the body
Part identifies matched transcranial magnetic stimulation as a result, to instruct the transcranial magnetic stimulation for carrying the transcranial magnetic stimulation result as the result is shown
It is sent to the stimulation presentation system, the transcranial magnetic stimulation result joins transcranial magnetic stimulation by the behavior evaluating system
Number is counted to obtain, and the transcranial magnetic stimulation parameters include the transcranial magnetic stimulation main body after n times transcranial magnetic stimulation
Recognition tests output is as a result, the transcranial magnetic stimulation instructs as the result is shown and is used to indicate the stimulation presentation system and shows the warp
Cranium Neural stem cell result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811625440.0A CN109481845B (en) | 2018-12-28 | 2018-12-28 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811625440.0A CN109481845B (en) | 2018-12-28 | 2018-12-28 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109481845A true CN109481845A (en) | 2019-03-19 |
| CN109481845B CN109481845B (en) | 2022-04-01 |
Family
ID=65713006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811625440.0A Active CN109481845B (en) | 2018-12-28 | 2018-12-28 | Method and related device for transcranial magnetic stimulation acting on different brain areas |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109481845B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021104098A1 (en) * | 2019-11-28 | 2021-06-03 | 中国科学院深圳先进技术研究院 | Nerve regulation system and wearable nerve regulation device |
| WO2024103468A1 (en) * | 2022-11-18 | 2024-05-23 | 深圳先进技术研究院 | Transcranial magnetic stimulation system for relieving anxiety, device, and medium |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2733301A1 (en) * | 2001-05-04 | 2002-11-14 | Board Of Regents, The University Of Texas System | Apparatus and methods for delivery of transcranial magnetic stimulation |
| US20050256539A1 (en) * | 2002-03-25 | 2005-11-17 | George Mark S | Methods and systems for using transcranial magnetic stimulation to enhance cognitive performance |
| US20100256438A1 (en) * | 2007-08-20 | 2010-10-07 | Mishelevich David J | Firing patterns for deep brain transcranial magnetic stimulation |
| CN103429146A (en) * | 2011-03-03 | 2013-12-04 | 奈科斯迪姆公司 | Cognitive mapping using transcranial magnetic stimulation |
| CN104981265A (en) * | 2012-11-25 | 2015-10-14 | 斯蒂文·理查德·德沃尔·贝斯特 | Treatment of thalamocortical dysrhythmia |
| CN105771092A (en) * | 2016-04-01 | 2016-07-20 | 深圳市前海安测信息技术有限公司 | System and method for improving sleep based on electromagnetic field |
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| CN106345062A (en) * | 2016-09-20 | 2017-01-25 | 华东师范大学 | Transcranial magnetic stimulation coil positioning method based on magnetic resonance imaging |
| CN107577343A (en) * | 2017-08-25 | 2018-01-12 | 北京航空航天大学 | It is a kind of based on the notice of haptic device and electroencephalogramsignal signal analyzing training and evaluating apparatus |
| CN107847744A (en) * | 2015-06-01 | 2018-03-27 | 赛威医疗公司 | Apparatus and method for nerve modulation |
| CN108042917A (en) * | 2017-12-13 | 2018-05-18 | 深圳先进技术研究院 | The Enhancement Method and device of more object tracking abilities |
-
2018
- 2018-12-28 CN CN201811625440.0A patent/CN109481845B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2733301A1 (en) * | 2001-05-04 | 2002-11-14 | Board Of Regents, The University Of Texas System | Apparatus and methods for delivery of transcranial magnetic stimulation |
| US20050256539A1 (en) * | 2002-03-25 | 2005-11-17 | George Mark S | Methods and systems for using transcranial magnetic stimulation to enhance cognitive performance |
| US20100256438A1 (en) * | 2007-08-20 | 2010-10-07 | Mishelevich David J | Firing patterns for deep brain transcranial magnetic stimulation |
| CN103429146A (en) * | 2011-03-03 | 2013-12-04 | 奈科斯迪姆公司 | Cognitive mapping using transcranial magnetic stimulation |
| CN104981265A (en) * | 2012-11-25 | 2015-10-14 | 斯蒂文·理查德·德沃尔·贝斯特 | Treatment of thalamocortical dysrhythmia |
| CN107847744A (en) * | 2015-06-01 | 2018-03-27 | 赛威医疗公司 | Apparatus and method for nerve modulation |
| CN106075731A (en) * | 2016-03-02 | 2016-11-09 | 深圳英智科技有限公司 | Based on the dyskinetic method of transcranial magnetic stimulation treatment post-stroke |
| CN105771092A (en) * | 2016-04-01 | 2016-07-20 | 深圳市前海安测信息技术有限公司 | System and method for improving sleep based on electromagnetic field |
| CN106345062A (en) * | 2016-09-20 | 2017-01-25 | 华东师范大学 | Transcranial magnetic stimulation coil positioning method based on magnetic resonance imaging |
| CN107577343A (en) * | 2017-08-25 | 2018-01-12 | 北京航空航天大学 | It is a kind of based on the notice of haptic device and electroencephalogramsignal signal analyzing training and evaluating apparatus |
| CN108042917A (en) * | 2017-12-13 | 2018-05-18 | 深圳先进技术研究院 | The Enhancement Method and device of more object tracking abilities |
Non-Patent Citations (3)
| Title |
|---|
| LINGDI FU 等: ""Effect of Transcranial Magnetic Stimulation of Acupuncture Point on Brain Network"", 《 IEEE TRANSACTIONS ON MAGNETICS》 * |
| 方方 等: ""我国认知神经科学的研究现状及发展建议"", 《中国科学基金》 * |
| 黄蓓 等: ""诊断性经颅磁刺激研究进展"", 《中国现代神经疾病杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021104098A1 (en) * | 2019-11-28 | 2021-06-03 | 中国科学院深圳先进技术研究院 | Nerve regulation system and wearable nerve regulation device |
| WO2024103468A1 (en) * | 2022-11-18 | 2024-05-23 | 深圳先进技术研究院 | Transcranial magnetic stimulation system for relieving anxiety, device, and medium |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109481845B (en) | 2022-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sitaram et al. | Closed-loop brain training: the science of neurofeedback | |
| McKinley et al. | Acceleration of image analyst training with transcranial direct current stimulation. | |
| Gendron et al. | Emotion words shape emotion percepts. | |
| CN103917156B (en) | For the method and apparatus strengthening brain activity | |
| Suthana et al. | Percepts to recollections: insights from single neuron recordings in the human brain | |
| CN108042917B (en) | Method and device for enhancing multi-object tracking capability | |
| EP1493097A1 (en) | Method and device for the electromagnetic modification of cerebral activity | |
| US9878155B1 (en) | Method for neurostimulation enhanced team performance | |
| CN109481845A (en) | A kind of method and relevant apparatus of the transcranial magnetic stimulation acting on Different brain region | |
| McKinley et al. | The effects of transcranial direct current stimulation (tDCS) on training during a complex procedural task | |
| CN109363671A (en) | Construction method based on the SSVEP mood dynamic brain network merged with ERP | |
| CN106137170B (en) | A kind of intelligent foot shock system based on biofeedback | |
| Folstein et al. | The effect of category learning on visual attention and visual representation | |
| Husain et al. | Simulating transcranial magnetic stimulation during PET with a large-scale neural network model of the prefrontal cortex and the visual system | |
| Kim et al. | Modulation of electrophysiology by transcranial direct current stimulation in psychiatric disorders: a systematic review | |
| Caulfield et al. | Optimizing transcranial direct current stimulation (tDCS) electrode position, size, and distance doubles the on-target cortical electric field: Evidence from 3000 Human Connectome Project models | |
| Pisoni et al. | TMS orientation and pulse waveform manipulation activates different neural populations: direct evidence from TMS-EEG | |
| Rossini et al. | Neurophysiological techniques in the study of the excitability, connectivity, and plasticity of the human brain | |
| CN112402800A (en) | Method for enhancing visual search capability and related device | |
| Pancholi et al. | Quantification of electric field strength of tDCS in alzheimer’s and mild cognitive impairment patients | |
| Lorenz et al. | Assessing tACS-induced phosphene perception using closed-loop Bayesian optimization | |
| Kim et al. | Neuromodulation of inhibitory control using phase-lagged transcranial alternating current stimulation | |
| Ezzyat et al. | Brain Stimulation | |
| Wang | Closed-loop brain-computer interfaces for memory restoration using deep brain stimulation | |
| US20230398353A1 (en) | System and method for non-invasive brain stimulation of cognitive enhancement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |