CN109481556A - For treating medicament of burn and scald and preparation method thereof in a kind of clinical care - Google Patents

For treating medicament of burn and scald and preparation method thereof in a kind of clinical care Download PDF

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Publication number
CN109481556A
CN109481556A CN201811551746.6A CN201811551746A CN109481556A CN 109481556 A CN109481556 A CN 109481556A CN 201811551746 A CN201811551746 A CN 201811551746A CN 109481556 A CN109481556 A CN 109481556A
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scald
burn
medicament
clinical care
treating
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朱科科
王芳
唐滋贵
王艳丽
马莉
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Henan Medical College
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Henan Medical College
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/889Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses, for treating the medicament of burn and scald, belong to the field of Chinese medicines in a kind of clinical care.It is characterized in that, being made of the component of following parts by weight: catechu 30-55g, garden burnet 30-55g, rheum officinale 30-55g, honeysuckle 20-30g, dragon's blood 15-25g, borneol 15-25g, alcohol 1000mL.The present invention also provides the preparation methods of above-mentioned Chinese medicine composition.The present invention has the effect of clearing heat and detoxicating, eliminating dampness and astringing sores, reparative regeneration, can be used for burn and scald caused by a variety of causes, is easy to use in clinical care, alleviates the pain of patient, and effectively treat burn and scald, nurses convenient for medical staff.

Description

For treating medicament of burn and scald and preparation method thereof in a kind of clinical care
Technical field
The present invention relates to traditional Chinese medical science fields, and in particular to for treating medicament and its preparation of burn and scald in a kind of clinical care Method.
Background technique
Burn and scald is common unexpected injury in life, boiling water, rolling congee, hot oil, heat steam burning scald and can often occur Thing.Burn and scald presses depth, is generally divided into three degree, once burn and scald: only injuring epidermis, injured rubefaction, swelling are felt Smartly pain, but appearance without blister;Two degree of burn and scalds: injuring skin corium, and part is red and swollen, generates heat, in great pain, there is obvious water Bubble;Three degree of burn and scalds: full thickness skin includes that fat, bone and the muscle below skin all come to harm, and skin is burned black, downright bad, this When instead pain it is inviolent because many nerves are also all damaged together.
At present treatment burn and scald external drug it is varied, generally using have anti-inflammatory, analgesic, myogenic function patch Agent, tincture class drug, main component is in the majority with Western medicine, and general composition containing antibiotic is notably controlled using injection, surgical operation Treat, not only treatment cost is high, the period is long, validity, safety, in terms of there is also many drawbacks.It is protected in clinic In reason, it has been found that ointment, the lotion for treating burn and scald that patient uses in the past are harder, are not easy to push open, be easy to the open sore part It causes to tear, and gas permeability reduces, and the open sore part is be easy to cause to fester.Therefore, the present invention has studied in a kind of clinical care for controlling The medicament of burn and scald is treated, medicament is sprayed on the burn surface of patient by way of spray, mitigates the pain of patient, and convenient for doctor Protect personal care.
Summary of the invention
The purpose of the invention is to overcome the problems of the prior art, provides and scalded in a kind of clinical care for treating to burn Medicament of wound and preparation method thereof.
The present invention provides the medicaments for being used to treat burn and scald in a kind of clinical care, by the component system of following parts by weight At: catechu 30-55g, garden burnet 30-55g, rheum officinale 30-55g, honeysuckle 20-30g, dragon's blood 15-25g, borneol 15-25g, alcohol 1000mL。
Preferably, being made of the component of following parts by weight: youngster in a kind of clinical care for treating the medicament of burn and scald Tea 40g, garden burnet 40g, rheum officinale 40g, honeysuckle 25g, dragon's blood 20g, borneol 20g, alcohol 1000mL.
Preferably, the concentration of the alcohol is 75%-95%.
The present invention also provides in above-mentioned clinical care for treat burn and scald medicament preparation method, specifically include with Lower step:
Step 1, weigh according to parts by weight catechu 30-55g, garden burnet 30-55g, rheum officinale 30-55g, honeysuckle 20-30g, Dragon's blood 15-25g, borneol 15-25g, alcohol 1000mL, it is spare;
Step 2, will be dry after weighed catechu, garden burnet, rheum officinale, honeysuckle, dragon's blood cleaning, it is then ground to powder, mistake 200-300 mesh obtains Traditional Chinese drug mixture, and Traditional Chinese drug mixture is put into alcohol and is stirred evenly, and obtains within sealed soak 8-12 days Medicine mixed liquor;
Step 3, weighed borneol is dissolved in alcohol, obtains the medicament for treating burn and scald.
Preferably, dry temperature is 45-60 DEG C in step 2.
Preferably, the soaking temperature of the sealed soak is 30~35 DEG C in step 2, soaking time is 10 days.
Compared with prior art, the beneficial effect of the present invention one is:
The present invention has the effect of clearing heat and detoxicating, eliminating dampness and astringing sores, reparative regeneration, can be used for burning caused by a variety of causes and scald Wound is easy to use in clinical care, is alleviated the pain of patient, and effectively treat burn and scald, is alleviated medical staff's Burden.Wherein, catechu, garden burnet have heat-clearing and damp-drying drug sore, keep the surface of a wound dry, the effect of a large amount of sepage exudations are prevented, to protect Hold patient's electrolyte, the balance of albumen creates advantage, honeysuckle have clearing heat and cooling blood myogenic function, be able to suppress bacterium Breeding, effectively prevent the infection of empyrosis wound surface, dragon's blood, borneol have promoting blood circulation and stopping pain, the effect of detumescence and promoting granulation, to make to burn Scald wound is quickly repaired.For treating the medicament of burn and scald in a kind of clinical care provided by the invention, medicament passes through spraying The mode of agent is sprayed on the burn surface of patient, and surface of a wound drying is promoted medicine scab to be formed by blowing, it is not easy to cause to tear to the open sore part, breathe freely Property it is preferable, the open sore part is not easy to fester, convenient for medical staff nurse, significantly mitigate patient pain.
Specific embodiment
Specific embodiments of the present invention will be described in detail below, it is to be understood that protection scope of the present invention is not It is restricted by specific implementation.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creativeness Every other embodiment obtained, shall fall within the protection scope of the present invention under the premise of labour.
For treating the medicament of burn and scald in a kind of clinical care provided by the invention, by the component system of following parts by weight At: catechu 30-55g, garden burnet 30-55g, rheum officinale 30-55g, honeysuckle 20-30g, dragon's blood 15-25g, borneol 15-25g, alcohol 1000mL。
Said components are respectively provided with following effect and effect:
Catechu, garden burnet have heat-clearing and damp-drying drug sore, keep the surface of a wound dry, the effect of a large amount of sepage exudations are prevented, to keep Patient's electrolyte, albumen balance create advantage, honeysuckle has the function of clearing heat and cooling blood myogenic, is able to suppress bacterium Breeding, effectively prevent the infection of empyrosis wound surface, and dragon's blood, borneol have promoting blood circulation and stopping pain, the effect of detumescence and promoting granulation.
Below with reference to some specific embodiments, technical solution of the present invention is further illustrated.
Embodiment 1
The present embodiment provides the medicaments for being used to treat burn and scald in a kind of clinical care, by the component system of following parts by weight At:
Catechu 40g, garden burnet 40g, rheum officinale 40g, honeysuckle 25g, dragon's blood 20g, borneol 20g, 95% alcohol 1000mL.
In above-mentioned clinical care for treat burn and scald medicament preparation method the following steps are included:
Step 1, catechu 40g, garden burnet 40g, rheum officinale 40g, honeysuckle 25g, dragon's blood 20g, borneol are weighed according to parts by weight 20g, 95% alcohol 1000mL, it is spare;
Step 2, will be dry after weighed catechu, garden burnet, rheum officinale, honeysuckle, dragon's blood cleaning, drying temperature is 50 DEG C, so Grind into powder afterwards crosses 250 meshes and obtains Traditional Chinese drug mixture, Traditional Chinese drug mixture is put into alcohol and is stirred evenly, and is impregnating temperature Chinese medicine mixed liquor is obtained within sealed soak 10 days under conditions of 32 DEG C of degree;
Step 3, weighed borneol is dissolved in alcohol, obtains the medicament for treating burn and scald, the medicament that will be obtained It is fitted into sprayer, it is primary every 3 hours spraying medicaments in early days, and dry and promote medicine scab to be formed surface of a wound drying, at scab jail Gu after, each spraying is primary daily morning and evening.
Embodiment 2
The present embodiment provides the medicaments for being used to treat burn and scald in a kind of clinical care, by the component system of following parts by weight At:
Catechu 30g, garden burnet 55g, rheum officinale 30g, honeysuckle 30g, dragon's blood 15g, borneol 25g, 75% alcohol 1000mL.
In above-mentioned clinical care for treat burn and scald medicament preparation method the following steps are included:
Step 1, catechu 30g, garden burnet 55g, rheum officinale 30g, honeysuckle 30g, dragon's blood 15g, borneol are weighed according to parts by weight 25g, 75% alcohol 1000mL, it is spare;
Step 2, will be dry after weighed catechu, garden burnet, rheum officinale, honeysuckle, dragon's blood cleaning, drying temperature is 45 DEG C, so Grind into powder afterwards crosses 200 meshes and obtains Traditional Chinese drug mixture, Traditional Chinese drug mixture is put into alcohol and is stirred evenly, and is impregnating temperature Chinese medicine mixed liquor is obtained within sealed soak 8 days under conditions of 30 DEG C of degree;
Step 3, weighed borneol is dissolved in alcohol, obtains the medicament for treating burn and scald, the medicament that will be obtained It is fitted into sprayer, it is primary every 3 hours spraying medicaments in early days, and dry and promote medicine scab to be formed surface of a wound drying, at scab jail Gu after, each spraying is primary daily morning and evening.
Embodiment 3
The present embodiment provides the medicaments for being used to treat burn and scald in a kind of clinical care, by the component system of following parts by weight At:
Catechu 55g, garden burnet 30g, rheum officinale 55g, honeysuckle 20g, dragon's blood 25g, borneol 15g, 75% alcohol 1000mL.
In above-mentioned clinical care for treat burn and scald medicament preparation method the following steps are included:
Step 1, catechu 55g, garden burnet 30g, rheum officinale 55g, honeysuckle 20g, dragon's blood 25g, borneol are weighed according to parts by weight 15g, 75% alcohol 1000mL, it is spare;
Step 2, will be dry after weighed catechu, garden burnet, rheum officinale, honeysuckle, dragon's blood cleaning, drying temperature is 60 DEG C, so Grind into powder afterwards crosses 300 meshes and obtains Traditional Chinese drug mixture, Traditional Chinese drug mixture is put into alcohol and is stirred evenly, and is impregnating temperature Chinese medicine mixed liquor is obtained within sealed soak 12 days under conditions of 35 DEG C of degree;
Step 3, weighed borneol is dissolved in alcohol, obtains the medicament for treating burn and scald, the medicament that will be obtained It is fitted into sprayer, it is primary every 3 hours spraying medicaments in early days, and dry and promote medicine scab to be formed surface of a wound drying, at scab jail Gu after, each spraying is primary daily morning and evening.
Some Clinic Cases are set forth below and by taking the formula of embodiment 1 as an example, illustrate the effect of medicament of the present invention.
One, clinical trial
1, patient data
Selection of clinical
Total case load: 160 people, wherein 80 people of male, 80 people of women, minimal ages 6 years old, max age 60 years old, average year Age was at 45 years old or less.Wherein 80 people of I degree burn and scald, 80 people of II degree burn and scald.
2, diagnostic criteria:
The damage of I degree burn and scald is most light.Burn and scald rubefaction, obviously touches, has exudation or oedema at pain.Light pressure is injured Locally bleach when position, but there is no bubble.The damage of II degree burn and scald is deeper.Skin blister.Bubble bottom takes on a red color or white, fills Limpid, sticky liquid is expired.Tenderness is sensitive, and when compressing bleaches 3, curative effect judging standard
1), analgesic effect: pain is substantially reduced to be effective, pain relief be it is effective, pain has no that it is invalid for mitigating.
2), anti-inflammatory effects: do not occur inflammation be it is effective, it is invalid for inflammation occur;3, detumescence effect: it is aobvious for disappearing after medication Effect, redness are got better to be effective, and redness has no that abatement is invalid;4, restrain, corruption gone to go myogenic effect of itching: no scar be it is effective, have Slightly scar is effective, and scar is evident as in vain.All indexs are that effective person is judged to fully recovering: two or two or more indexs are aobvious Effect, remaining index responder are effective;Two or two or more index nonresponders be it is invalid, remaining is effective.
4, treatment method
Test group: obtained medicament is fitted into sprayer, primary every 3 hours spraying medicaments in early days, and is dried and will be created Face drying promotes medicine scab to be formed, and after secured at scab, each spraying is primary daily morning and evening.The I degree burn and scald course for the treatment of is set to 7 days, The II degree burn and scald course for the treatment of is set to 14 days
5, treatment results
In 180 treatment cases, concrete result for the treatment statistics is as follows:
Group Healing/people Effectively/people In vain/people Total effective rate/%
Test group 120 52 8 95.56
Clinical test of the present invention proves, for treating the medicine of burn and scald in a kind of clinical care that the present invention is prepared Agent is sprayed at empyrosis wound surface position, and very easy to use, therapeutic effect is good.
It should be noted that involved in claims of the present invention when numberical range, it is thus understood that each numberical range Any one numerical value can be selected between two endpoints and two endpoints, since the step method of use is identical as embodiment, It repeats in order to prevent, description of the invention preferred embodiment, since the effect of Examples 1 to 3 is similar, the present invention only describes The effect of embodiment 1.Although an embodiment of the present invention has been shown and described, for those of ordinary skill in the art and Speech, it is possible to understand that these embodiments can be carried out with a variety of variations without departing from the principles and spirit of the present invention, repaired Change, replacement and variant, the scope of the present invention is defined by the appended.

Claims (6)

1. for treating the medicament of burn and scald in a kind of clinical care, which is characterized in that be made of the component of following parts by weight: Catechu 30-55g, garden burnet 30-55g, rheum officinale 30-55g, honeysuckle 20-30g, dragon's blood 15-25g, borneol 15-25g, alcohol 1000mL。
2. for treating the medicament of burn and scald in clinical care as described in claim 1, which is characterized in that by following parts by weight Several components are made: catechu 40g, garden burnet 40g, rheum officinale 40g, honeysuckle 25g, dragon's blood 20g, borneol 20g, alcohol 1000mL.
3. for treating the medicament of burn and scald in clinical care as described in claim 1, which is characterized in that the alcohol it is dense Degree is 75%-95%.
4. for treating the preparation method of the medicament of burn and scald in clinical care as described in claim 1, which is characterized in that packet Include following steps:
Step 1, catechu 30-55g, garden burnet 30-55g, rheum officinale 30-55g, honeysuckle 20-30g, dragon's blood are weighed according to parts by weight 15-25g, borneol 15-25g, alcohol 1000mL, it is spare;
Step 2, will be dry after weighed catechu, garden burnet, rheum officinale, honeysuckle, dragon's blood cleaning, it is then ground to powder, crosses 200- 300 meshes obtain Traditional Chinese drug mixture, and Traditional Chinese drug mixture is put into alcohol and is stirred evenly, and it is mixed to obtain within sealed soak 8-12 days Chinese medicine Close liquid;
Step 3, weighed borneol is dissolved in alcohol, obtains the medicament for treating burn and scald.
5. for treating the preparation method of the medicament of burn and scald in clinical care as claimed in claim 4, which is characterized in that step In rapid 2, dry temperature is 45-60 DEG C.
6. for treating the preparation method of the medicament of burn and scald in clinical care as claimed in claim 4, which is characterized in that step In rapid 2, the soaking temperature of the sealed soak is 30~35 DEG C, and soaking time is 10 days.
CN201811551746.6A 2018-12-19 2018-12-19 For treating medicament of burn and scald and preparation method thereof in a kind of clinical care Pending CN109481556A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1778360A (en) * 2004-11-27 2006-05-31 黄贵昌 Burn and scald medicine
CN103463246A (en) * 2013-08-02 2013-12-25 上海惠林生物科技有限公司 Externally-applied Chinese herbal medicine fast effective preparation capable of treating burns and scalds, and preparation process

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1778360A (en) * 2004-11-27 2006-05-31 黄贵昌 Burn and scald medicine
CN103463246A (en) * 2013-08-02 2013-12-25 上海惠林生物科技有限公司 Externally-applied Chinese herbal medicine fast effective preparation capable of treating burns and scalds, and preparation process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
朱宝贵: "湿敷疗法的临床应用", 《中国初级卫生保健》 *
陈月文,等: "自制大黄酊治疗烧烫伤30例", 《四川中医》 *

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Application publication date: 20190319

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