CN109481070A - A kind of implantable internal carotid constant speed injection device and its operating method - Google Patents
A kind of implantable internal carotid constant speed injection device and its operating method Download PDFInfo
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- CN109481070A CN109481070A CN201910021986.3A CN201910021986A CN109481070A CN 109481070 A CN109481070 A CN 109481070A CN 201910021986 A CN201910021986 A CN 201910021986A CN 109481070 A CN109481070 A CN 109481070A
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- arteria carotis
- carotis communis
- constant speed
- injection
- implantation catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses a kind of implantable internal carotid constant speed injection device and its operating methods.The present invention use i.e. sealing is respectively set on the top of arteria carotis communis implantation catheter and rear end again can be by sealing cover and sealing-plug that syringe needle punctures, the injection openings covered by one-way flow open gate are set in the front end of arteria carotis communis implantation catheter, pass through controller coutroi velocity and time, it drives constant speed injection micro pump to push syringe, cancer cell or injection drug is flowed into common carotid artery by the injection openings of arteria carotis communis implantation catheter；The present invention can easy operation method, simplify operating procedure, shorten operating time；Meanwhile by the modus operandi of the complete animal model for changing mouse Internal carotid artery injection, the external carotid artery for tying mouse is not needed, vagus nerve and blood vessel will not be damaged, substantially increases the success rate of operation.
Description
Technical field
The present invention relates to mouse model technologies, and in particular to a kind of implantable internal carotid constant speed injection device and its
Operating method.
Background technique
When making the mouse model of each quasi-cancer cell brain metastes, it usually needs the arteria carotis communis proximal part of mouse
And ligation of external carotid artery, the good cancer cell of in vitro culture is then injected into neck from arteria carotis communis distal end inserting needle using syringe
Interior artery reaches blood-brain barrier, then spontaneous metastasis makes and the most similar mouse model of human cancer brain metastes to intracerebral.
According to Local Anatomy: arteria carotis communis is divided into forward external carotid artery and internal carotid, the only blood stream in internal carotid
To encephalic.Therefore, having only just can make the blood flow in arteria carotis communis all flow into internal carotid forward ligation of external carotid artery.Due to
Mouse operation needs to carry out under the microscope, and surgical procedure must be very fine, the step of most critical is desirable in surgical procedure
The external carotid artery for ligaturing mouse, then could be injected into completely internal carotid for cancer cell with syringe and be transferred to brain, tie neck
It must be noted that protection is injury-free with the vagus nerve and vein blood vessel of row when outer artery, otherwise will will cause mouse core and jump all standing
And blood loss, this is the major reason of operative failure dead mouse.In addition, needing that cancer will be filled thin after ligation external carotid artery success
The syringe needle of the syringe of born of the same parents is pierced into arteria carotis communis distal end (above proximal part ligature), then to Internal carotid artery injection in vitro culture
Good cancer cell, injection process needs strict control injection speed, i.e., in the case that cancer cell concentration is certain, injection speed is got over
Fastly, the cancer cell number that blood-brain barrier is reached in the unit time is more, can cause cancer embolus artificially to block blood vessel, be equivalent to
Mouse is caused to suffer from large area thrombotic diseases and dead, this is also another major reason of operative failure dead mouse.
Summary of the invention
For the above problems of the prior art, the invention proposes a kind of injections of implantable internal carotid constant speed to fill
It sets and its operating method, to improve the success rate of mouse model production, reduces the death rate of mouse.
An object of the present invention is to provide a kind of implantable internal carotid constant speed injection devices.
Implantable internal carotid constant speed injection device of the invention includes: arteria carotis communis implantation catheter, sealing cover, sealing
Plug, injection openings, one-way flow open gate, marker, syringe needle, syringe, propeller, constant speed injection micro pump and controller；Wherein,
Arteria carotis communis implantation catheter is the columnar hollow tubing conductor of inner hollow；The top of arteria carotis communis implantation catheter is provided with sealing
Lid, rear end is provided with sealing-plug；Injection openings are offered on the side wall of the front end of arteria carotis communis implantation catheter；In injection openings
Place and it is located at outside arteria carotis communis implantation catheter and is provided with one-way flow door, covers injection openings, the front end connection of one-way flow open gate
On the side wall of the front end of arteria carotis communis implantation catheter, one-way flow open gate can be around junction outside arteria carotis communis implantation catheter
Folding；The front end of arteria carotis communis implantation catheter is provided with marker；Arteria carotis communis implantation catheter, sealing cover, sealing-plug, injection
Opening, one-way flow open gate and marker constitute arteria carotis communis implanted device；The front end connecting needle of syringe, the shape of syringe needle are
Broken line type with obtuse angle；Syringe needle, which penetrates sealing-plug, to be goed deep into arteria carotis communis implantation catheter；The piston handle of syringe bottom end connects
It is connected to propeller；Propeller is connected to constant speed injection micro pump；Constant speed injection micro pump is connected to controller；The empty cylinder of syringe
It is provided with injected material, by the rate of controller setting injection, control constant speed injection micro pump drives propeller, pushes syringe
Piston handle, by injected material by syringe needle inject arteria carotis communis implantation catheter in, by injection openings, wash one-way flow open gate stream open
Out；After injection, since the pressure of blood reflux is better than the pressure in arteria carotis communis implantation catheter, i.e. arteria carotis communis implantation is led
It is negative pressure in pipe, one-way flow open gate is closed.
Operation consent is being carried out, arteria carotis communis implantation catheter is inserted into common carotid artery, after operation, neck is always moved
Arteries and veins implantation catheter takes out.
Arteria carotis communis implantation catheter uses polyvinylchloride, polythene PE or polyphenyl alkene PS.Arteria carotis communis implantation catheter
0.5~0.75mm of internal diameter；Outer diameter is 1~1.25mm.
The material of sealing cover and sealing-plug is using one of rubber, latex and silica gel.
It is 3~4mm that the diameter of injection openings, which is at a distance from 1~2mm, with arteria carotis communis implantation catheter top,.The present invention adopts
The top of arteria carotis communis implantation catheter is blocked with sealing cover, and injection openings are set in the side wall of arteria carotis communis implantation catheter,
To which injected material is all injected into internal carotid, without tying the external carotid artery of mouse, vagus nerve will not be damaged
And blood vessel.
One-way flow door is set outside injection openings, and in carrying out injection process, injected material can wash one-way flow open gate open
Outflow, after injection, due to being negative pressure in arteria carotis communis implantation catheter, the closing of one-way flow open gate covers injection openings,
To prevent in the blood backflow to arteria carotis communis implantation catheter in internal carotid.
Marker uses bar, and bar surface is coated with fluorescer；Bar tightly sticks at the inner surface of sealing cover.
The obtuse angle of syringe needle is 120~145 °, is not only convenient for the puncture procedure of common carotid artery, is more convenient for being implanted into neck and always move
Arteries and veins implantation catheter, and when progress injection operation, the common carotid artery of mouse will not be damaged to.
Syringe includes empty cylinder, piston and piston handle；In the syringe needle of the top of empty cylinder setting connection, set in the bottom end of piston
Piston handle is set, the front end of piston is goed deep into from the bottom end of empty cylinder to empty cylinder.
Propeller includes push top and lead screw；Wherein, the piston handle of the front end of push top and syringe connects, and rear end and lead screw connect
It connects, lead screw is connected to constant speed injection micro pump.Constant speed injection micro pump is controlled by controller, and the control signal of controller drives permanent
Speed injection micro pump, drives screw rod rotation, and screw rod drives the push top of front end to advance again, and push top can be by the rotary motion of screw rod pair
It is changed into linear motion, so that the piston of the syringe of push top front end be pushed to carry out cancer cell or drug injection.
Controller includes power supply, input unit, output device and control circuit board；Wherein, power supply is respectively connected to input
Device, output device and control circuit board；Control circuit board is respectively connected to input unit and output device；Pass through input unit
Infusion velocity, injection time and injection total amount are set, output device uses display screen, and display screen is liquid crystal display LCD.Pass through
The infusion velocity and injection time that set constant speed injection micro pump control the rotation speed of screw rod in turn, reach control syringe
The forward speed of piston.
The dosage of infusion is 500~200 μ l；The rate of constant injection is 0.50~1.0 μ l/s, and injection length is
100~200s.
Further, the invention also includes protective case, protective case is sleeved on outside arteria carotis communis implanted device.
Injected material is the various injection drugs of the various cancer cells shifted to brain or treatment.
It is another object of the present invention to provide a kind of operating methods of implantable internal carotid constant speed injection device.
The operating method of implantable internal carotid constant speed injection device of the invention, comprising the following steps:
1) injected material is filled in syringe；
2) piston handle of syringe bottom end is connected to propeller；
3) propeller is connected to constant speed injection micro pump；
4) constant speed injection micro pump is connected to controller；
5) syringe needle with obtuse angle sealing-plug is penetrated to go deep into arteria carotis communis implantation catheter；Sealing cover exposing is penetrated again
Needle point；
6) needle point is retracted in arteria carotis communis implantation catheter；
7) by the rate of controller setting injection, control constant speed injection micro pump drives propeller, pushes syringe
Injected material is injected in arteria carotis communis implantation catheter by syringe needle, by injection openings, washes one-way flow open gate stream open by piston handle
Out；
8) after injecting, due to being negative pressure, the closing of one-way flow open gate in arteria carotis communis implantation catheter.
Advantages of the present invention:
The present invention, which uses, to be respectively set i.e. sealing on the top of arteria carotis communis implantation catheter and rear end and can be pierced by syringe needle
The injection openings covered by one-way flow open gate are arranged in the front end of arteria carotis communis implantation catheter for broken sealing cover and sealing-plug, lead to
Controller coutroi velocity and time are spent, driving constant speed injection micro pump pushes syringe, and cancer cell or injection drug are passed through neck
The injection openings of total artery implantation catheter flow into common carotid artery；The present invention can easy operation method, simplify operating procedure,
Shorten operating time；Meanwhile by the modus operandi of the complete animal model for changing mouse Internal carotid artery injection, do not need to tie small
The external carotid artery of mouse will not damage vagus nerve and blood vessel, substantially increase the success rate of operation.
Detailed description of the invention
Fig. 1 is the schematic diagram of one embodiment of arteria carotis communis implanted device of the invention；
Fig. 2 is the schematic diagram before the use of one embodiment of implantable internal carotid constant speed injection device of the invention；
Fig. 3 is the connection signal in the use of one embodiment of implantable internal carotid constant speed injection device of the invention
Figure.
Specific embodiment
With reference to the accompanying drawing, by specific embodiment, the present invention is further explained.
As illustrated in fig. 1 and 2, the implantable internal carotid constant speed injection device of the present embodiment includes: that arteria carotis communis implantation is led
Pipe 1, sealing cover 2, sealing-plug 3, injection openings, one-way flow open gate 4, marker, syringe needle 5, syringe 6, protective case 7, propeller,
Constant speed injects micro pump and controller；Wherein, arteria carotis communis implantation catheter 1 is the columnar hollow tubing conductor of inner hollow；Neck
The top of total artery implantation catheter 1 is provided with sealing cover 2, and rear end is provided with sealing-plug 3；Before arteria carotis communis implantation catheter 1
Injection openings are offered on the side wall at end；One-way flow is provided at injection openings and outside arteria carotis communis implantation catheter 1
Door covers injection openings, and the front end of one-way flow open gate is connected on the side wall of the front end of arteria carotis communis implantation catheter 1, one-way flow
Open gate can open and close outside arteria carotis communis implantation catheter 1 around junction；The front end of arteria carotis communis implantation catheter 1 is provided with mark
Remember object；Arteria carotis communis implantation catheter 1, sealing cover 2, sealing-plug 3, injection openings, one-way flow open gate 4 and marker constitute neck and always move
Arteries and veins implanted device；Protective case 7 is sleeved on outside arteria carotis communis implanted device；The front end connecting needle 5 of syringe 6, the shape of syringe needle 5
For the broken line type with obtuse angle；Syringe needle 5, which penetrates sealing-plug 3, to be goed deep into arteria carotis communis implantation catheter 1；The work of 6 bottom end of syringe
Plug handle is connected to propeller；Propeller is connected to constant speed injection micro pump；Constant speed injection micro pump is connected to controller；Syringe
6 empty cylinder is provided with injected material, and by the rate of controller setting injection, control constant speed injection micro pump drives propeller, pushes away
Injected material is injected in arteria carotis communis implantation catheter 1 by syringe needle 5, by injection openings, is washed open by the piston handle of dynamic syringe 6
The outflow of one-way flow open gate；After injection, since the pressure of blood reflux is better than the pressure in arteria carotis communis implantation catheter 1, i.e.,
It is negative pressure in arteria carotis communis implantation catheter 1, one-way flow open gate is closed.Syringe 6 includes empty cylinder 61, piston 62 and piston handle 63.
In the present embodiment, arteria carotis communis implantation catheter 1 uses polyvinylchloride；The material of sealing cover 2 and sealing-plug 3
Using rubber；It is 3mm that the diameter of injection openings, which is at a distance from 1mm, with 1 top of arteria carotis communis implantation catheter,.Marker, which uses, to be referred to
Show item, bar surface is coated with fluorescer and tightly sticks at the inner surface of sealing cover 2；The obtuse angle of syringe needle 5 is 135 °；The agent of infusion
Amount is 100 μ l；The rate of constant injection is 0.50 μ l/s, and injection length is between 100~200s.
The implantable internal carotid constant speed injection device of the present embodiment is for such as scheming in the operation of mouse Internal carotid artery injection
Shown in 3, operating method the following steps are included:
1) cancer cell or drug are filled in syringe 6；
2) piston handle of 6 bottom end of syringe is connected to propeller；
3) propeller is connected to constant speed injection micro pump；
4) constant speed injection micro pump is connected to controller；
5) protective case 7 is torn, arteria carotis communis implanted device is embedded to common carotid artery tube wall, will there are 135 ° of obtuse angles
Syringe needle 5, which penetrates sealing-plug 3, to be goed deep into arteria carotis communis implantation catheter 1；Sealing cover 2 is penetrated again exposes needle point；
6) common carotid artery tube wall is punctured with needle point, immediately retracts needle point in arteria carotis communis implantation catheter 1；
7) by the rate of controller setting injection, control constant speed injection micro pump drives propeller, pushes syringe 6
Injected material is injected in arteria carotis communis implantation catheter 1 by syringe needle 5, by injection openings, washes one-way flow open gate stream open by piston handle
Out；
8) after injecting, due to being negative pressure, the closing of one-way flow open gate in arteria carotis communis implantation catheter 1；
9) after performing the operation, arteria carotis communis implanted device is taken out.
It is finally noted that the purpose for publicizing and implementing example is to help to further understand the present invention, but this field
Technical staff be understood that without departing from the spirit and scope of the invention and the appended claims, it is various replacement and repair
It is all possible for changing.Therefore, the present invention should not be limited to embodiment disclosure of that, and the scope of protection of present invention is to weigh
Subject to the range that sharp claim defines.
Claims (10)
1. a kind of implantable internal carotid constant speed injection device, which is characterized in that the constant speed injection device includes: arteria carotis communis
Implantation catheter, sealing cover, sealing-plug, injection openings, one-way flow open gate, marker, syringe needle, syringe, propeller, constant speed injection
Micro pump and controller；Wherein, the arteria carotis communis implantation catheter is the columnar hollow tubing conductor of inner hollow；Arteria carotis communis
The top of implantation catheter is provided with sealing cover, and rear end is provided with sealing-plug；On the side wall of the front end of arteria carotis communis implantation catheter
Offer injection openings；One-way flow door, covering injection are provided at injection openings and outside arteria carotis communis implantation catheter
Opening, the front end of one-way flow open gate is connected on the side wall of the front end of arteria carotis communis implantation catheter, and one-way flow open gate can be around
Junction opens and closes outside arteria carotis communis implantation catheter；The front end of arteria carotis communis implantation catheter is provided with marker；The neck is total
Artery implantation catheter, sealing cover, sealing-plug, injection openings, one-way flow open gate and marker constitute arteria carotis communis implanted device；Note
The front end connecting needle of emitter, the shape of syringe needle are the broken line type with obtuse angle；Syringe needle penetrates sealing-plug deeply to arteria carotis communis
In implantation catheter；The piston handle of syringe bottom end is connected to propeller；Propeller is connected to constant speed injection micro pump；Constant speed injection
Micro pump is connected to controller；The empty cylinder of syringe is provided with injected material, by the rate of controller setting injection, controls constant speed
It injects micro pump and drives propeller, push the piston handle of syringe, injected material is injected into arteria carotis communis implantation catheter by syringe needle
It is interior, by injection openings, wash the outflow of one-way flow open gate open；After injection, since the pressure of blood reflux is better than arteria carotis communis
It is negative pressure in pressure in implantation catheter, i.e. arteria carotis communis implantation catheter, one-way flow open gate is closed.
2. constant speed injection device as described in claim 1, which is characterized in that the arteria carotis communis implantation catheter uses polychlorostyrene second
Alkene PVC, polythene PE or polyphenyl alkene PS；0.5~0.75mm of internal diameter of the arteria carotis communis implantation catheter；Outer diameter be 1~
1.25mm。
3. constant speed injection device as described in claim 1, which is characterized in that the material of the sealing cover and sealing-plug uses rubber
One of glue, latex and silica gel.
4. constant speed injection device as described in claim 1, which is characterized in that the diameter of the injection openings is 1~2mm, with
The distance on arteria carotis communis implantation catheter top is 3~4mm.
5. constant speed injection device as described in claim 1, which is characterized in that the marker uses bar, bar table
Face is coated with fluorescer；Bar tightly sticks at the inner surface of sealing cover.
6. constant speed injection device as described in claim 1, which is characterized in that the obtuse angle of the syringe needle is 120~145 °.
7. constant speed injection device as described in claim 1, which is characterized in that the controller includes power supply, input unit, defeated
Device and control circuit board out；Wherein, power supply is respectively connected to input unit, output device and control circuit board；Control circuit
Plate is respectively connected to input unit and output device；Infusion velocity and injection time are set by input unit.
8. constant speed injection device as described in claim 1, which is characterized in that further include protective case, the protective case is sleeved on
Outside arteria carotis communis implanted device.
9. a kind of operating method of implantable internal carotid constant speed injection device as described in claim 1, which is characterized in that institute
State operating method the following steps are included:
1) injected material is filled in syringe；
2) piston handle of syringe bottom end is connected to propeller；
3) propeller is connected to constant speed injection micro pump；
4) constant speed injection micro pump is connected to controller；
5) syringe needle with obtuse angle sealing-plug is penetrated to go deep into arteria carotis communis implantation catheter；Sealing cover is penetrated again exposes needle
Point；
6) needle point is retracted in arteria carotis communis implantation catheter；
7) by the rate of controller setting injection, control constant speed injection micro pump drives propeller, pushes the piston of syringe
Handle injects injected material in arteria carotis communis implantation catheter by syringe needle, by injection openings, washes the outflow of one-way flow open gate open；
8) after injecting, due to being negative pressure, the closing of one-way flow open gate in arteria carotis communis implantation catheter.
10. operating method as claimed in claim 9, which is characterized in that in step 7), the rate of constant injection is 0.50
~1.0 μ l/s, injection length are 100~200s.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910021986.3A CN109481070B (en) | 2019-01-10 | 2019-01-10 | Implantable internal carotid artery constant-speed injection device and operation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910021986.3A CN109481070B (en) | 2019-01-10 | 2019-01-10 | Implantable internal carotid artery constant-speed injection device and operation method thereof |
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| CN109481070B CN109481070B (en) | 2023-04-25 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112121253A (en) * | 2020-10-10 | 2020-12-25 | 南通伊诺精密塑胶导管有限公司 | Radiography catheter |
| CN113521489A (en) * | 2020-11-20 | 2021-10-22 | 首都医科大学 | Small animal drainage and administration device |
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| CN109481070B (en) | 2023-04-25 |
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