CN109480284A - A kind of Ketogenic diet and preparation method thereof - Google Patents
A kind of Ketogenic diet and preparation method thereof Download PDFInfo
- Publication number
- CN109480284A CN109480284A CN201811486038.9A CN201811486038A CN109480284A CN 109480284 A CN109480284 A CN 109480284A CN 201811486038 A CN201811486038 A CN 201811486038A CN 109480284 A CN109480284 A CN 109480284A
- Authority
- CN
- China
- Prior art keywords
- beta
- hydroxy
- butanoic acid
- component
- carnitine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000020887 ketogenic diet Nutrition 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical class CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims abstract description 37
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical group C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 25
- 229960004203 carnitine Drugs 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 11
- 239000000194 fatty acid Substances 0.000 claims abstract description 11
- 229930195729 fatty acid Natural products 0.000 claims abstract description 11
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 11
- -1 aliphatic ester Chemical class 0.000 claims abstract description 5
- 239000007902 hard capsule Substances 0.000 claims description 38
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 26
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 20
- IDXSBEJSTGNYLT-UHFFFAOYSA-N 3-hydroxybutanoic acid;magnesium Chemical compound [Mg].CC(O)CC(O)=O IDXSBEJSTGNYLT-UHFFFAOYSA-N 0.000 claims description 15
- 235000019359 magnesium stearate Nutrition 0.000 claims description 13
- 239000000377 silicon dioxide Substances 0.000 claims description 13
- WCTKPXDSIKEWNM-UHFFFAOYSA-N calcium;3-hydroxybutanoic acid Chemical compound [Ca].CC(O)CC(O)=O WCTKPXDSIKEWNM-UHFFFAOYSA-N 0.000 claims description 12
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 12
- HUDYFJHHUDBBHE-UHFFFAOYSA-N 3-hydroxybutanoic acid;potassium Chemical compound [K].CC(O)CC(O)=O HUDYFJHHUDBBHE-UHFFFAOYSA-N 0.000 claims description 11
- CWQQGENZHRKCMJ-UHFFFAOYSA-N 3-hydroxybutanoic acid;sodium Chemical compound [Na].CC(O)CC(O)=O CWQQGENZHRKCMJ-UHFFFAOYSA-N 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 229920002472 Starch Polymers 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- 239000008107 starch Substances 0.000 claims description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000007901 soft capsule Substances 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- JXXCENBLGFBQJM-UHFFFAOYSA-N (3-carboxy-2-hydroxypropyl)-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC(O)CC(O)=O JXXCENBLGFBQJM-UHFFFAOYSA-N 0.000 claims description 2
- 235000013361 beverage Nutrition 0.000 claims description 2
- 229960001518 levocarnitine Drugs 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 abstract description 53
- 235000013305 food Nutrition 0.000 abstract description 32
- 239000008280 blood Substances 0.000 abstract description 30
- 210000004369 blood Anatomy 0.000 abstract description 30
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 19
- 239000008103 glucose Substances 0.000 abstract description 19
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 13
- 235000003642 hunger Nutrition 0.000 abstract description 10
- 102000004877 Insulin Human genes 0.000 abstract description 9
- 108090001061 Insulin Proteins 0.000 abstract description 9
- 229940125396 insulin Drugs 0.000 abstract description 9
- 235000005686 eating Nutrition 0.000 abstract description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 7
- 230000008859 change Effects 0.000 abstract description 6
- 230000037351 starvation Effects 0.000 abstract description 4
- 238000012423 maintenance Methods 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 2
- 230000004580 weight loss Effects 0.000 abstract description 2
- 235000019197 fats Nutrition 0.000 description 13
- 235000009200 high fat diet Nutrition 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 239000011812 mixed powder Substances 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 208000008589 Obesity Diseases 0.000 description 3
- 210000001789 adipocyte Anatomy 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 208000030814 Eating disease Diseases 0.000 description 2
- 208000019454 Feeding and Eating disease Diseases 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- JXXCENBLGFBQJM-FYZOBXCZSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride Chemical class [Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O JXXCENBLGFBQJM-FYZOBXCZSA-N 0.000 description 2
- 231100000460 acute oral toxicity Toxicity 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- BYFFFNTZKJUEFW-UHFFFAOYSA-N calcium;2-hydroxybutanoic acid Chemical compound [Ca].CCC(O)C(O)=O BYFFFNTZKJUEFW-UHFFFAOYSA-N 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 235000014632 disordered eating Nutrition 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000004118 muscle contraction Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BQMPVGMHZKZPBH-BYZBDTJCSA-N (3r)-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O.C[N+](C)(C)C[C@H](O)CC([O-])=O BQMPVGMHZKZPBH-BYZBDTJCSA-N 0.000 description 1
- QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- HNSUOMBUJRUZHJ-UEMBJLSASA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;(e)-4-hydroxy-4-oxobut-2-enoate Chemical compound OC(=O)\C=C\C(O)=O.C[N+](C)(C)C[C@H](O)CC([O-])=O HNSUOMBUJRUZHJ-UEMBJLSASA-N 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 description 1
- 229960001009 acetylcarnitine Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical compound NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 238000009739 binding Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- FYPVXEILSNEKOO-UHFFFAOYSA-L calcium;butanoate Chemical compound [Ca+2].CCCC([O-])=O.CCCC([O-])=O FYPVXEILSNEKOO-UHFFFAOYSA-L 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 230000004140 ketosis Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000007248 oxidative elimination reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000020989 red meat Nutrition 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000036228 toxication Effects 0.000 description 1
- 235000021404 traditional food Nutrition 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000002918 waste heat Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of Ketogenic diets and preparation method thereof, are related to field of food.The Ketogenic diet, raw material contain following component: component a, component b and component c；Wherein, component a is beta-hydroxy-butanoic acid salt, beta-hydroxy-butanoic acid ester or combinations thereof；Component b is carnitine；Component c is fatty acid, aliphatic ester or combinations thereof.The physiological change gone on a hunger strike can be simulated by eating Ketogenic diet weight-reducing, avoidable eater endures starvation, glucose and insulin level will not rise and fall sharply and quickly, maintain reduced levels, composition component has a collaboration enhancement effect, and physical manifestations go out to have no toxic side effect, weight loss or maintenance, improves and maintenance blood ketone levels, blood glucose level is reduced, fat-reducing effect is reached.
Description
Technical field
The present invention relates to field of food, in particular to a kind of Ketogenic diet and preparation method thereof.
Background technique
Obesity is one group of common metabolic syndrome.When the human body consumes more calories than it consumes, waste heat is with rouge
Fat form is stored in vivo, amount be more than normal physiological requirement, and reach certain value when develop into obesity then.Normal male at
The 15%-18% of human fat tissue weight percentage of liveweight, women account for 20%-25%.Increase with the age, body fat proportion accordingly increases
Add.
Traditional method of weight-reducing is typically necessary the intake of limitation calorie, and this method makes one usually in hungry shape
State, light are difficult to persevere with willpower.In addition, blood glucose and insulin are always in big rise in the state of high-carbon water diet
In the circulation fallen greatly, the big rise and big fall of appetite are easy to cause, eating disorder is caused.
In consideration of it, the present invention is specifically proposed.
Summary of the invention
The purpose of the present invention is to provide a kind of Ketogenic diets.The physiology gone on a hunger strike can be simulated by eating Ketogenic diet weight-reducing
Variation, avoidable eater endure starvation, and glucose and insulin level will not rise and fall sharply and quickly, and maintain reduced levels, body
Body surface reveals effective fat-reducing effect.
Another object of the present invention is to provide a kind of preparation methods of Ketogenic diet.
The present invention is implemented as follows:
On the one hand, the present invention provides a kind of Ketogenic diet, raw material contains following component: component a, component b and group
Divide c；
Wherein, component a is beta-hydroxy-butanoic acid salt, beta-hydroxy-butanoic acid ester or combinations thereof；
Component b is carnitine；
Component c is fatty acid, aliphatic ester or combinations thereof.
Further, in some embodiments of the present invention, the beta-hydroxy-butanoic acid salt is selected from beta-hydroxy-butanoic acid sodium, β-
In hydroxybutyric acid calcium, beta-hydroxy-butanoic acid magnesium, beta-hydroxy-butanoic acid potassium and beta-hydroxy-butanoic acid ester-amino acid complex any one or
Several combinations (certainly, it should be noted that these combinations can also contain chipal compounds combination).
Beta-hydroxy-butanoic acid salt can be absorbed into blood, there it can decomposite free ion (such as sodium, potassium, calcium,
Magnesium).Since beta-hydroxy-butanoic acid is a kind of group water solution, more ketones can be added in blood by eating the product.This can be with
The body of eater is allowed to obtain better energy production.It is most stable when in conjunction with the minerals such as beta-hydroxy-butanoic acid and sodium, calcium or magnesium.It
Additional benefit is provided by additional electrolyte needed for manufacture ketone and nutrient.
Beta-hydroxy-butanoic acid Salt treatment ketosis state and the selection for improving blood ketone level, such as:
Beta-hydroxy-butanoic acid potassium: by allowing more potassium ions to enter the body of eater, ionic potassium passes through the fortune of cell membrane
It is dynamic to help to promote contraction of muscle and nerve impulse.
Beta-hydroxy-butanoic acid sodium: by allowing more sodium ions to enter the body of eater, ionic sodium passes through the fortune of cell membrane
It is dynamic to help to promote contraction of muscle and nerve impulse.
Beta-hydroxy-butanoic acid calcium: in order to avoid the intake of excessive sodium ion, by beta-hydroxy-butanoic acid calcium, absorption slows down, for
It is suitable for the personnel of strenuous exercise.
Beta-hydroxy-butanoic acid magnesium: magnesium ion is the key component of human body, due to perspiring and arranging for trainer and sportsman
Urine increases, and the personnel that magnesium ion can be lost, therefore take regular exercise, which take beta-hydroxy-butanoic acid magnesium, can reduce the risk of magnesium shortage.
Beta-hydroxy-butanoic acid and different ions bindings and different regions can be targeted.It is taken in when lacking carbohydrate
When, these compounds ideally act synergistically in the body.
Further, in some embodiments of the present invention, the carnitine is selected from L-carnitine, acetylcarnitine and carnitine
Any one or the combination of several of them in hydrochloride.
Further, in some embodiments of the present invention, the carnitine is selected from L-carnitine, l-carnitine fumaric acid
Any one or the combination of several of them in salt, acetyl-L-carnitine and L-carnitine hydrochloride.
L-carnitine (L-carnitine), also known as l-carnitine or transliteration Carnitine are that one kind promotes adipose conversion for energy
Amino acid, red meat is the main source of L-carnitine, is had no toxic and side effect to human body.The major physiological function of L-carnitine
Can promote adipose conversion at energy, water can not be reduced while reducing body fat, losing weight by taking L-carnitine
Point and muscle, regarded as most safe fat-reducing nutrient complementary goods without side-effects by International Obesity health tissues in 2003.
L-carnitine is the substance of one of fat metabolic process key, fatty acid can be promoted to enter mitochondrial oxidation
It decomposes.
Further, in some embodiments of the present invention, the fatty acid is medium chain triglyceride.
Medium chain triglyceride (MCT), link is shorter, not will become Fat Accumulation in human body, while MCT can give
Feeling of repletion can allow people to reduce food intake.It is in order to which the intake for reducing carbohydrate has feeling of repletion in formula.
It should be noted that above-mentioned fatty acid or fatty acid can be it is natural (for example, cream, coconut oil, Australia are hard
Fruit oil etc.) it is also possible to artificial, those skilled in the art can select according to use demand, belong to of the invention
Protection scope.
Further, in some embodiments of the present invention, component a is beta-hydroxy-butanoic acid salt, the beta-hydroxy-butanoic acid
Salt includes beta-hydroxy-butanoic acid sodium, beta-hydroxy-butanoic acid calcium, beta-hydroxy-butanoic acid magnesium and beta-hydroxy-butanoic acid potassium；
The carnitine is acetyl-L-carnitine；
Component c is medium chain triglyceride.
Further, in some embodiments of the present invention, by weight, the raw material contains: beta-hydroxy-butanoic acid
2-8 parts of sodium, 2-8 parts of beta-hydroxy-butanoic acid calcium, 2-8 parts of beta-hydroxy-butanoic acid magnesium, 1-10 parts of beta-hydroxy-butanoic acid potassium, L-carnitine 10-15
Part and medium chain triglyceride 10-15 parts.
Further, in some embodiments of the present invention, by weight, the raw material contains: 10 parts of beta-hydroxies
Calcium butyrate, 4 parts of beta-hydroxy-butanoic acid magnesium, 4 parts of beta-hydroxy-butanoic acid sodium, 1 part of beta-hydroxy-butanoic acid potassium, 10 parts of acetyl-L-carnitines and 10
Part medium chain triglyceride.
Further, in some embodiments of the present invention, the Ketogenic diet further includes acceptable in bromatology
Auxiliary material.
Further, in some embodiments of the present invention, the auxiliary material includes one or more of following component:
Phosphatide bee soybean oil, starch, silica and magnesium stearate.
It should be noted that those skilled in the art can need to select according to the dosage form of above-mentioned Ketogenic diet it is different
Auxiliary material, such as select phosphatide bee soybean oil auxiliary material that soft capsule can be made；Or leucine is used, lysine, arginine organizes ammonia
Acid, ornithine, creatine, agmatine, citrulling and or combinations thereof, then mix starch, silica and magnesium stearate and be made into firmly
Capsule.
Further, in some embodiments of the present invention, the dosage form of the Ketogenic diet is capsule, pulvis, piece
Agent or solid beverage.For example, the dosage form of Ketogenic diet of the invention can be hard capsule, it is also possible to soft capsule.
High fat diet (ketogenic diet), exactly generates the diet of ketoboidies (keto body).Ketoboidies is fatty acid
The product of metabolism, in simple terms, ketoboidies are exactly that fat becomes.
Why will fat become ketoboidies? because some bodily tissues (mainly brain, there are also nervous systems) cannot
Glucose can be first looked for when they need the energy for the energy using directly can be regarded as using fatty acid, if glucose is inadequate
With ketoboidies must just be pushed up as the energy up, and raw ketone process is with regard to this generation.
The generation of ketoboidies must be as caused by carbon water insufficiency of intake.As long as the intake of carbon water is lower than 100g, ketoboidies will be opened
Begin to generate, carbon water is lower, and ketoboidies generates more.High fat diet used in practice, generally require the intake of carbon water in 50g or
30g is hereinafter, certainly this requirement is intended merely to ketoboidies and can generate the diet more, 100g or less carbon water is taken in fact
High fat diet can be referred to as.
Other than carbon water, protein also a little influences raw ketone effect because glucose can be metabolised to.For
The extreme high fat diet of medical treatment situation (treatment epilepsy), carbon water and protein are all confined extremely low, and fat is for can exceed that 90%.
Certain few people use the high fat diet for forcing down protein in fat reducing occasion.
Traditional method of weight-reducing is typically necessary limitation calorie, makes one to taste and is in the state of " hungry ", and light is with will
Power is difficult to persevere.And in the state of high-carbon water diet, blood glucose and insulin are always in the circulation of big rise and big fall,
The big rise and big fall of appetite are easy to cause, eating disorder is caused.
Ketogenic diet provided by the invention is exactly the Ketogenic diet for manufacturing low-carbon water, after eating, body is allowed to rapidly enter life
Ketone state.
High fat diet (low-carbon water, appropriate protein, high-fat) imitates the physiological change gone on a hunger strike, while can also allow eater
That eats is full full, does not need to endure hunger pangs.Blood glucose and insulin are also relatively stable, maintain appetite stable to reach
Effect.
On the other hand, the present invention also provides a kind of preparation methods for preparing above-mentioned Ketogenic diet comprising: by component a,
Component b and component c mixing.
Ketogenic diet provided by the invention has the following characteristics that
1, after eating Ketogenic diet provided by the invention, high fat diet lean on extremely low carbohydrate the characteristics of, imitate
The physiological change gone on a hunger strike.Meanwhile because of high-fat intake, can allow the stomach of eater eats is full, does not need to endure starvation
Pain.
2, eating after Ketogenic diet provided by the invention is exactly to reduce blood insulin level.High fat diet is lost weight most heavy
One of principle wanted is exactly to reduce insulin, locks grease in fat cell to " release ", and by these greases
As the fuel of body, efficient supplying energy.
3, when eating traditional food, body override uses glucose, and extra glucose is then converted into fat
It stores in case of need, and these fat are difficult out then by firmly " lock exists " fat cell.On the contrary, edible
After after Ketogenic diet provided by the invention, for eater in raw ketone state, glucose and insulin level are relatively low, and fat is very
It is easy to come out from fat cell, fat reducing just seems relatively easy.
4, after eating Ketogenic diet provided by the invention, the endurance for improving body and physical manifestations can effectively lose weight effect
Fruit has cancer prevention, and cognition improves and the characteristics such as anti-inflammatory.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is after taking the life ketone capsule-shaped food that 4 embodiments 2 provide in experimental example 2, and the intracorporal blood ketone of subject is horizontal
Result of variations.
Fig. 2 is after taking the life ketone capsule-shaped food that 2 embodiments 2 provide in experimental example 2, and the intracorporal blood ketone of subject is horizontal
Result of variations.
Fig. 3 is the changes of weight result of subject after taking Ketogenic diet in experimental example 3.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
Raw ketone hard capsule food provided in this embodiment, by weight, raw material include: 8 parts of beta-hydroxy-butanoic acid calcium, 5
Part beta-hydroxy-butanoic acid magnesium, 2 parts of beta-hydroxy-butanoic acid sodium, 10 parts of acetyl-L-carnitines, 10 parts of medium chain triglyceride powderies (MCT)；Its
Auxiliary material includes: 50 parts of starch, 5 parts of silica and 10 parts of magnesium stearates.
Hard capsule Ketogenic diet provided in this embodiment the preparation method is as follows:
(1) it learns from else's experience and qualified beta-hydroxy-butanoic acid salt, carnitine, MCT, silica and magnesium stearate is examined to remove supplementary material
Outer packing is gone, inner packing is by entering clean area between buffering；
(2) it is sieved: beta-hydroxy-butanoic acid salt, carnitine, MCT, silica and Magnesium Stearate is spare；
(3) it weighs: it is spare to weigh beta-hydroxy-butanoic acid salt, carnitine, MCT, silica and magnesium stearate by formula rate；
(4) one is mixed: by load weighted beta-hydroxy-butanoic acid salt, carnitine, MCT, with multidirectional three-dimensional motion mixer mixing 50-
Mixed powder is made in 60min；
(5) two is mixed: load weighted starch, silica and magnesium stearate mixing 30- is added in the mixed powder of step (4)
40min obtains total mixed powder；
(6) by total filling capsule of mixed powder automatic hard capsule filler, capsule, as this implementation filling capsule: are obtained
The life ketone hard capsule food of example, 500mg/；I.e. every contains the total mixed powder of 500mg.But it should be noted that of the invention
It, can be directly using total mixed powder of step (5) as Ketogenic diet of the invention, i.e., in others in some other embodiments
Filling capsule step can be used as optional step in embodiment.
(7) it polishes, select: removing the powder of capsule surface；Remove underproof product；Packaging, quality inspection, storage.
(8) preferably, clean area temperature and humidity described in the step (1) is respectively 40 DEG C -45 DEG C, and 40%.Preferably, institute
It states the entire preparation process in step (2)-(7) to complete in certain clean area, ensure that the cleaning of working environment, to the greatest extent
Reduce influence of the environment to capsule.
Embodiment 2
Hard capsule Ketogenic diet provided in this embodiment, by weight, raw material include: 10 parts of β-by weight
Hydroxybutyric acid calcium, 4 parts of beta-hydroxy-butanoic acid magnesium, 4 parts of beta-hydroxy-butanoic acid sodium, 1 part of beta-hydroxy-butanoic acid potassium, 10 parts of acetyl-L-carnitines,
10 parts of medium chain triglyceride powderies (MCT)；Its auxiliary material includes: 50 parts of starch, 5 parts of silica and 10 parts of magnesium stearates.
The preparation method of hard capsule Ketogenic diet provided in this embodiment is substantially the same manner as Example 1.
Embodiment 3
Hard capsule Ketogenic diet provided in this embodiment, by weight, raw material include: 5 parts of beta-hydroxy-butanoic acid calcium, 2
Part beta-hydroxy-butanoic acid magnesium, 8 parts of beta-hydroxy-butanoic acid sodium, 10 parts of acetyl-L-carnitines, 10 parts of medium chain triglyceride powderies (MCT)；Its
Auxiliary material includes: 50 parts of starch, 5 parts of silica and 10 parts of magnesium stearates.
The preparation method of hard capsule Ketogenic diet provided in this embodiment is substantially the same manner as Example 1.
Embodiment 4
Hard capsule Ketogenic diet provided in this embodiment, by weight, raw material include: 2 parts of beta-hydroxy-butanoic acid calcium, 8
Part beta-hydroxy-butanoic acid magnesium, 5 parts of beta-hydroxy-butanoic acid sodium, 15 parts of acetyl-L-carnitines, 10 parts of medium chain triglyceride powderies (MCT)；Its
Auxiliary material includes: 45 parts of starch, 5 parts of silica and 10 parts of magnesium stearates.
The preparation method of hard capsule Ketogenic diet provided in this embodiment is substantially the same manner as Example 1.
Embodiment 5
Raw ketone hard capsule food provided in this embodiment, by weight, raw material include: 2 parts of beta-hydroxy-butanoic acid calcium, 2
Part beta-hydroxy-butanoic acid magnesium, 2 parts of beta-hydroxy-butanoic acid sodium, 10 parts of beta-hydroxy-butanoic acid potassium, 10 parts of L-carnitine hydrochlorides, chain is sweet in 12 parts
Oily three ester powderies, 45 parts of starch, 5 parts of silica, 10 parts of magnesium stearates.
The preparation method of hard capsule Ketogenic diet provided in this embodiment is substantially the same manner as Example 1.
Embodiment 6
Raw ketone hard capsule food provided in this embodiment, by weight, raw material include: 2 parts of beta-hydroxy-butanoic acid calcium, 4
Part beta-hydroxy-butanoic acid magnesium, 2 parts of beta-hydroxy-butanoic acid sodium, 10 parts of beta-hydroxy-butanoic acid potassium, 10 parts of L-carnitine hydrochlorides, chain is sweet in 12 parts
Oily three ester powderies, 45 parts of starch, 5 parts of silica, 10 parts of magnesium stearates.
The preparation method of hard capsule Ketogenic diet provided in this embodiment is substantially the same manner as Example 1.
Experimental example 1
The life ketone hard capsule food that short time orally administration embodiment 2 provides is detected, it is anti-to observe toxicity caused by animal
It answers.
1 material and method:
(1) experimental animal: SPF grades of selection healthy Kunming mouses 20,18~22 grams of weight, half male and half female.
(2) experimental animal feeding environment: SPF Animal Lab, 20~25 DEG C of room temperature, relative humidity 40~70%.
(3) prepare stomach-filling solution: the life ketone hard capsule food that Example 2 provides takes out the powder in capsule；It weighs
50.00g powder is added 1% sodium carboxymethylcellulose to 100mL, stomach-filling solution is made, Ketogenic diet concentration is 0.5g/
ml。
2 experimental methods
After experimental mouse fasting 16h, (refer to that every mouse gives 15g powder by every kg weight with the dosage of 15.0g/kgBW
Not), by the way of stomach-filling, animal subject, each stomach-filling amount are orally given above-mentioned stomach-filling to solution in two times in 6 hours in interval
For 0.15m1/10gBW (referring to that every mouse gives 0.15ml above-mentioned stomach-filling solution by every 10g weight).At any time in observation
Poison performance and death condition are observed continuously two weeks, measure a weight weekly.
4 results
Acute oral toxicity result of the life ketone hard capsule food that 1 embodiment of table provides to mouse
It the results are shown in Table 1, after animal subject takes orally the life ketone hard capsule food that above-described embodiment 2 provides, do not occur in obvious
Toxication shape, without animal dead in the observation period, each animal main organs are shown no obvious abnormalities in postmortem.Thus illustrate above-described embodiment
The life ketone hard capsule food of offer is foodstuffs without toxicity to chmice acute Oral toxicity LD50 > 15.0g/kgBW.
Experimental example 2
Detection eats the blood ketone level after Ketogenic diet provided in an embodiment of the present invention
(1) after once taking the Ketogenic diet of 4 embodiments, every 30min detects internal blood ketone content, the results are shown in Table 2 and figure
1.Intermediate product acetoacetate, beta-hydroxy-butanoic acid and the acetone of oxidative cleavage of fatty acids, three are referred to as ketoboidies.Blood ketone is exactly ketone
Body should be 10mg/L-60mg/L (i.e. 0.1722mmol/L- in content in blood, unit mmol/L, blood ketone normal value
1.0332mmol/L)
Table 2: the intracorporal blood ketone changes of contents of subject after the life ketone hard capsule food of 4 embodiments 2 is taken
After taking the life ketone hard capsule food that the embodiment of the present invention 2 provides it can be seen from 2 result of Fig. 1 and table, subject
Blood ketone level increases, and shows that its body enters raw ketone state, fat is decomposing.
(2) disposably after the life ketone capsule-shaped food of oral 2 above-described embodiments 2, every 30min detection subject (people) is internal
Blood ketone content (unit: mmol/L), the results are shown in Table 3 and Fig. 2.
Table 3: the intracorporal blood ketone changes of contents of subject after the life ketone hard capsule food of 2 embodiments 2 is taken
After taking the life ketone hard capsule food that the embodiment of the present invention 2 provides it can be seen from 3 result of Fig. 2 and table, subject
Blood ketone level increases, and body enters raw ketone state, and fat is decomposing.
Experimental example 3
The changes of weight after the life ketone hard capsule food of above-described embodiment is taken in detection
(1) experimental design: twice a day, each taking the life ketone hard capsule food that 2 embodiments 2 provide, daily in morning
It takes, continuously takes three months before dinner, and the carbohydrate within 100g can only be fed daily, edible vegetables, and
Beef, animal meat cannot eat egg.Experimental period: September 15th -2018 years on the 15th July in 2018.Every month detection by
As a result examination person's changes of weight is shown in Fig. 3 and table 4.
Table 4: the changes of weight of subject after the life ketone hard capsule food of embodiment 2 is taken
From table 4, it can be seen that weight is reducing, fat-reducing effect after subject takes the life ketone hard capsule food of embodiment 2
Obviously.
Experimental example 4
The full account sense after the life ketone hard capsule food of above-described embodiment is taken in detection.
Experimental design: the life ketone hard capsule food of 3 embodiments 2 offer is taken before having lunch.Then every 30min investigation
The full account sense of subject, the results are shown in Table 5.
Table 5: the full account sense Strength Changes of subject after the life ketone hard capsule food of embodiment 2 are taken
| Subject | 30min | 60min | 120min |
| First | There is full sense | Have | It does not starve |
| Second | Slightly | Have | It does not starve |
| Third | Full sense | Full sense | It does not starve |
| Fourth | Full sense | Full sense | It does not starve |
| Penta | Full sense | Full sense | It does not starve |
As can be seen from Table 5, the life ketone hard capsule food of the offer of embodiment 2 is provided, has full sense, Ke Yirang in subject's stomach
Subject reduces the desire of edible normal diet.Facilitate the intake that subject controls normal diet.
Experimental example 5
The blood glucose level after the life ketone hard capsule food of above-described embodiment is taken in detection
Experimental design: once a day, every after taking each taking the life ketone hard capsule food that 3 embodiments 2 provide
The blood glucose level of 30min detection subject.It the results are shown in Table 6.
Table 6: the blood glucose level variation of subject after the life ketone hard capsule food of embodiment 2 is taken
| Subject | 30min | 60min | 120min |
| First | 8.5 | 8.2 | 7.9 |
| Second | 9.2 | 8.6 | 8.0 |
| Third | 10 | 9.4 | 8.6 |
| Fourth | 9.6 | 8.6 | 7.9 |
| Penta | 8.6 | 8.0 | 7.8 |
As can be seen from Table 6, after subject takes the life ketone hard capsule food of the offer of embodiment 2, the blood glucose in 30 minutes
Level rises, and after two hours, blood sugar recovery is normal.Show that adipose conversion rises, change of blood sugar is less, and urgency does not occur in blood glucose
The phenomenon that according to rising or falling.
It should be noted that experiments verify that, the life ketone hard capsule food of embodiment 1 and 3-6 and the life ketone of embodiment 2 are hard
Capsule-shaped food has the effect of essentially identical.
To sum up, it can be seen that Ketogenic diet provided in an embodiment of the present invention can simulate the physiological change gone on a hunger strike, and can avoid
Eater endures starvation, and edible rear glucose and insulin level will not rise and fall sharply and quickly, and maintains reduced levels, eater's body
Body surface reveal have no toxic side effect, weight loss or maintenance, improve and maintain blood ketone levels, reduce blood glucose level, reach weight-reducing
Effect.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of Ketogenic diet, which is characterized in that its raw material contains following component: component a, component b and component c；
Wherein, component a is beta-hydroxy-butanoic acid salt, beta-hydroxy-butanoic acid ester or combinations thereof；
Component b is carnitine；
Component c is fatty acid, aliphatic ester or combinations thereof.
2. Ketogenic diet according to claim 1, which is characterized in that the beta-hydroxy-butanoic acid salt is selected from beta-hydroxy-butanoic acid
It is any in sodium, beta-hydroxy-butanoic acid calcium, beta-hydroxy-butanoic acid magnesium, beta-hydroxy-butanoic acid potassium and beta-hydroxy-butanoic acid ester-amino acid complex
One or more of combinations.
3. Ketogenic diet according to claim 2, which is characterized in that the carnitine is selected from L-carnitine, l-carnitine richness horse
Any one or the combination of several of them in hydrochlorate, acetyl-L-carnitine and L-carnitine hydrochloride.
4. Ketogenic diet according to claim 3, which is characterized in that the fatty acid is medium chain triglyceride.
5. according to the described in any item Ketogenic diets of claim 2-4, which is characterized in that component a is beta-hydroxy-butanoic acid salt, described
Beta-hydroxy-butanoic acid salt includes beta-hydroxy-butanoic acid sodium, beta-hydroxy-butanoic acid calcium, beta-hydroxy-butanoic acid magnesium and beta-hydroxy-butanoic acid potassium；
The carnitine is acetyl-L-carnitine；
Component c is medium chain triglyceride.
6. Ketogenic diet according to claim 5, which is characterized in that by weight, the raw material contains: beta-hydroxy fourth
Sour sodium 2-8 parts, 2-8 parts of beta-hydroxy-butanoic acid calcium, 2-8 parts of beta-hydroxy-butanoic acid magnesium, 1-10 parts of beta-hydroxy-butanoic acid potassium, L-carnitine 10-
15 parts and medium chain triglyceride 10-15 parts.
7. Ketogenic diet according to claim 6, which is characterized in that the Ketogenic diet further includes being subjected in bromatology
Auxiliary material.
8. Ketogenic diet according to claim 7, which is characterized in that the auxiliary material includes one of following component or several
Kind: phosphatide bee soybean oil, starch, silica and magnesium stearate.
9. Ketogenic diet according to claim 1, which is characterized in that the dosage form of the Ketogenic diet be capsule, pulvis,
Tablet or solid beverage；
Preferably, capsule is soft capsule or hard capsule.
10. as the described in any item Ketogenic diets of claim 1-9 preparation method, characterized in that it comprises: by component a,
Component b and component c mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811486038.9A CN109480284A (en) | 2018-12-05 | 2018-12-05 | A kind of Ketogenic diet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811486038.9A CN109480284A (en) | 2018-12-05 | 2018-12-05 | A kind of Ketogenic diet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109480284A true CN109480284A (en) | 2019-03-19 |
Family
ID=65699276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811486038.9A Pending CN109480284A (en) | 2018-12-05 | 2018-12-05 | A kind of Ketogenic diet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109480284A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115153005A (en) * | 2022-07-27 | 2022-10-11 | 南京纽邦生物科技有限公司 | Beta-hydroxybutyric acid compositions |
| CN115835786A (en) * | 2020-02-06 | 2023-03-21 | 阿克塞斯全球科学有限责任公司 | Enantiomerically pure R-beta-hydroxybutyrate mixed salt-acid compositions |
| CN116018155A (en) * | 2020-08-26 | 2023-04-25 | 阿克塞斯全球科学有限责任公司 | Compositions containing HMB and ketone bodies and methods for increasing lean body mass to fat mass ratio |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| WO2024067584A1 (en) * | 2022-09-27 | 2024-04-04 | 南京纽邦生物科技有限公司 | Complex of 3-hydroxybutyric acid and sodium 3-hydroxybutyrate and preparation method therefor |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050245612A1 (en) * | 2004-05-03 | 2005-11-03 | Blass John P | Pharmaceutical compositions for metabolic insufficiencies |
| US20110243885A1 (en) * | 2007-07-31 | 2011-10-06 | Accera, Inc. | Use of Genomic Testing and Ketogenic Compounds for Treatment of Reduced Cognitive Function |
| CN105050594A (en) * | 2013-03-19 | 2015-11-11 | 南佛罗里达大学 | Compositions and methods for producing elevated and sustained ketosis |
| CN107343657A (en) * | 2017-06-05 | 2017-11-14 | 深圳市捷利康生物科技有限公司 | High fat diet formula powder |
| CN108348496A (en) * | 2015-12-04 | 2018-07-31 | 雀巢产品技术援助有限公司 | Medium chain triglycerides composition |
| AU2017225912A1 (en) * | 2016-03-03 | 2018-09-27 | Bill Elliot Cham | Glycoalkaloid combinations and various uses thereof |
-
2018
- 2018-12-05 CN CN201811486038.9A patent/CN109480284A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050245612A1 (en) * | 2004-05-03 | 2005-11-03 | Blass John P | Pharmaceutical compositions for metabolic insufficiencies |
| US20110243885A1 (en) * | 2007-07-31 | 2011-10-06 | Accera, Inc. | Use of Genomic Testing and Ketogenic Compounds for Treatment of Reduced Cognitive Function |
| CN105050594A (en) * | 2013-03-19 | 2015-11-11 | 南佛罗里达大学 | Compositions and methods for producing elevated and sustained ketosis |
| CN108348496A (en) * | 2015-12-04 | 2018-07-31 | 雀巢产品技术援助有限公司 | Medium chain triglycerides composition |
| AU2017225912A1 (en) * | 2016-03-03 | 2018-09-27 | Bill Elliot Cham | Glycoalkaloid combinations and various uses thereof |
| CN107343657A (en) * | 2017-06-05 | 2017-11-14 | 深圳市捷利康生物科技有限公司 | High fat diet formula powder |
Non-Patent Citations (1)
| Title |
|---|
| 潘道东: "《功能性食品添加剂》", 31 January 2006, 中国轻工业出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| CN115835786A (en) * | 2020-02-06 | 2023-03-21 | 阿克塞斯全球科学有限责任公司 | Enantiomerically pure R-beta-hydroxybutyrate mixed salt-acid compositions |
| EP4099848A4 (en) * | 2020-02-06 | 2024-03-06 | Axcess Global Sciences Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
| CN116018155A (en) * | 2020-08-26 | 2023-04-25 | 阿克塞斯全球科学有限责任公司 | Compositions containing HMB and ketone bodies and methods for increasing lean body mass to fat mass ratio |
| CN115153005A (en) * | 2022-07-27 | 2022-10-11 | 南京纽邦生物科技有限公司 | Beta-hydroxybutyric acid compositions |
| WO2024067584A1 (en) * | 2022-09-27 | 2024-04-04 | 南京纽邦生物科技有限公司 | Complex of 3-hydroxybutyric acid and sodium 3-hydroxybutyrate and preparation method therefor |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109480284A (en) | A kind of Ketogenic diet and preparation method thereof | |
| CN111972672A (en) | Composition with muscle increasing function and application thereof | |
| Santoso et al. | Early skip-a-day feeding of female broiler chicks fed high-protein realimentation diets. Performance and body composition | |
| Jalolov et al. | The role of nutrition in the management of chronic hepatitis | |
| Db et al. | Nutritional composition of selected shellfish consumed in Rivers State, Nigeria | |
| CN102753183A (en) | Agent for improving motility function | |
| CN102273581A (en) | Compound sweetener with high sweetness | |
| JP2003325149A (en) | Water-soluble nucleoprotein-containing healthy drink | |
| Begum | A textbook of foods, Nutrition & Dietetics | |
| Rani et al. | Nutrition Science | |
| US20220152093A1 (en) | Optimized nutrient salt composition | |
| Sigdel et al. | Micro minerals | |
| RU2818450C1 (en) | Weight reduction method | |
| Walker | Human nutrition | |
| Cammalleri et al. | Egg white injury | |
| Orucova | The exchange of protein in the brain | |
| Scalfi et al. | Protein balance during very-low-calorie diets for the treatment of severe obesity | |
| Pennington | Therapeutic nutrition: a practical guide | |
| KR20020079066A (en) | Noodles manufacturing method using powder of seaweed, seaweed, seaweed, and seaweed | |
| Pepito et al. | Nutritional Quality of the Egg Mass Locally Known as “Lukot’of the Wedge Seahare Dolabella auricularia (Lightfoot, 1786) | |
| Bourne | Nutrition and the War | |
| Chand | ROLE OF NUTRITION IN PHYSICAL AND MENTAL WELLBEING | |
| Nkirigacha et al. | To assess the food consumption practices, dietary intake and nutritional status of lactating mothers in the house hold after intervention in Mwanamukia-Nairobi | |
| Sh | The role of nutrition in the management of chronic hepatitis | |
| Jani | Changes in the Regulation of Energy Metabolism with Aging Nutraceutical Applications |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190319 |
|
| RJ01 | Rejection of invention patent application after publication |