CN109463749A - A kind of Chinese medicine and health food for alleviating menstrual period pain - Google Patents
A kind of Chinese medicine and health food for alleviating menstrual period pain Download PDFInfo
- Publication number
- CN109463749A CN109463749A CN201811422604.XA CN201811422604A CN109463749A CN 109463749 A CN109463749 A CN 109463749A CN 201811422604 A CN201811422604 A CN 201811422604A CN 109463749 A CN109463749 A CN 109463749A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- health food
- menstrual period
- period pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 67
- 208000002193 Pain Diseases 0.000 title claims abstract description 56
- 230000036407 pain Effects 0.000 title claims abstract description 56
- 235000013402 health food Nutrition 0.000 title claims abstract description 35
- 230000003821 menstrual periods Effects 0.000 title claims abstract description 35
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 25
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 24
- 244000268590 Euryale ferox Species 0.000 claims abstract description 24
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 24
- 235000011034 Rubus glaucus Nutrition 0.000 claims abstract description 24
- 235000009122 Rubus idaeus Nutrition 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 241000218231 Moraceae Species 0.000 claims abstract description 23
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000009421 Myristica fragrans Nutrition 0.000 claims abstract description 22
- 239000001702 nutmeg Substances 0.000 claims abstract description 22
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 12
- 239000000654 additive Substances 0.000 claims abstract description 10
- -1 kidney tonifying Substances 0.000 claims abstract description 9
- 239000002398 materia medica Substances 0.000 claims abstract description 9
- 244000235659 Rubus idaeus Species 0.000 claims abstract description 7
- 235000013305 food Nutrition 0.000 claims abstract description 7
- 244000270834 Myristica fragrans Species 0.000 claims abstract description 5
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 32
- 235000019441 ethanol Nutrition 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- 239000011707 mineral Substances 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 6
- 239000004375 Dextrin Substances 0.000 claims description 5
- 229920001353 Dextrin Polymers 0.000 claims description 5
- 108010064851 Plant Proteins Proteins 0.000 claims description 5
- 235000019425 dextrin Nutrition 0.000 claims description 5
- 235000015872 dietary supplement Nutrition 0.000 claims description 5
- 235000010755 mineral Nutrition 0.000 claims description 5
- 235000021118 plant-derived protein Nutrition 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 4
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 4
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 4
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- 235000018102 proteins Nutrition 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 3
- 241000207199 Citrus Species 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 claims description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 claims description 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims description 3
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims description 3
- 108010084695 Pea Proteins Proteins 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
- 108010073771 Soybean Proteins Proteins 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 229930003451 Vitamin B1 Natural products 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 229930003316 Vitamin D Natural products 0.000 claims description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010233 benzoic acid Nutrition 0.000 claims description 3
- 229960004365 benzoic acid Drugs 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 229910052804 chromium Inorganic materials 0.000 claims description 3
- 239000011651 chromium Substances 0.000 claims description 3
- 235000020971 citrus fruits Nutrition 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 239000010642 eucalyptus oil Substances 0.000 claims description 3
- 229940044949 eucalyptus oil Drugs 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 229910052748 manganese Inorganic materials 0.000 claims description 3
- 239000011572 manganese Substances 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 229960002216 methylparaben Drugs 0.000 claims description 3
- 235000013557 nattō Nutrition 0.000 claims description 3
- 235000019702 pea protein Nutrition 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 3
- 239000011669 selenium Substances 0.000 claims description 3
- 229910052711 selenium Inorganic materials 0.000 claims description 3
- 229960003885 sodium benzoate Drugs 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 235000019710 soybean protein Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 235000000346 sugar Nutrition 0.000 claims description 3
- 229960003495 thiamine Drugs 0.000 claims description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 3
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 3
- 235000010374 vitamin B1 Nutrition 0.000 claims description 3
- 239000011691 vitamin B1 Substances 0.000 claims description 3
- 235000019158 vitamin B6 Nutrition 0.000 claims description 3
- 239000011726 vitamin B6 Substances 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 235000019166 vitamin D Nutrition 0.000 claims description 3
- 239000011710 vitamin D Substances 0.000 claims description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 3
- 229940011671 vitamin b6 Drugs 0.000 claims description 3
- 229940046008 vitamin d Drugs 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 244000099147 Ananas comosus Species 0.000 claims description 2
- 235000007119 Ananas comosus Nutrition 0.000 claims description 2
- 102000004407 Lactalbumin Human genes 0.000 claims description 2
- 108090000942 Lactalbumin Proteins 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 2
- 235000019477 peppermint oil Nutrition 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 240000008790 Musa x paradisiaca Species 0.000 claims 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 abstract description 39
- 239000008280 blood Substances 0.000 abstract description 33
- 210000004369 blood Anatomy 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 25
- 201000010099 disease Diseases 0.000 abstract description 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 17
- 230000000202 analgesic effect Effects 0.000 abstract description 14
- 230000001105 regulatory effect Effects 0.000 abstract description 8
- 238000010792 warming Methods 0.000 abstract description 5
- 208000019901 Anxiety disease Diseases 0.000 abstract description 4
- 230000032683 aging Effects 0.000 abstract description 4
- 230000036506 anxiety Effects 0.000 abstract description 4
- 230000035622 drinking Effects 0.000 abstract description 4
- 230000002124 endocrine Effects 0.000 abstract description 4
- 235000008216 herbs Nutrition 0.000 abstract description 4
- 230000010354 integration Effects 0.000 abstract description 4
- 230000035790 physiological processes and functions Effects 0.000 abstract description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 37
- 239000002504 physiological saline solution Substances 0.000 description 26
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 20
- 238000000034 method Methods 0.000 description 18
- 239000000523 sample Substances 0.000 description 18
- 241000498779 Myristica Species 0.000 description 17
- 240000007651 Rubus glaucus Species 0.000 description 17
- 238000002474 experimental method Methods 0.000 description 17
- 229940079593 drug Drugs 0.000 description 16
- 210000000952 spleen Anatomy 0.000 description 16
- 230000007812 deficiency Effects 0.000 description 15
- 208000005171 Dysmenorrhea Diseases 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 230000008961 swelling Effects 0.000 description 13
- 238000010586 diagram Methods 0.000 description 12
- 210000004291 uterus Anatomy 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 11
- 206010013935 Dysmenorrhoea Diseases 0.000 description 10
- 239000000679 carrageenan Substances 0.000 description 10
- 235000010418 carrageenan Nutrition 0.000 description 10
- 229920001525 carrageenan Polymers 0.000 description 10
- 229940113118 carrageenan Drugs 0.000 description 10
- 235000009508 confectionery Nutrition 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 10
- COXVTLYNGOIATD-HVMBLDELSA-N CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O Chemical compound CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O COXVTLYNGOIATD-HVMBLDELSA-N 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 9
- 230000003110 anti-inflammatory effect Effects 0.000 description 9
- 229960003699 evans blue Drugs 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 229960000583 acetic acid Drugs 0.000 description 8
- 239000000262 estrogen Substances 0.000 description 8
- 229940011871 estrogen Drugs 0.000 description 8
- 210000002683 foot Anatomy 0.000 description 8
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 7
- 239000010839 body fluid Substances 0.000 description 7
- 230000001737 promoting effect Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 206010010774 Constipation Diseases 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
- 208000000114 Pain Threshold Diseases 0.000 description 6
- 230000036592 analgesia Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 230000008602 contraction Effects 0.000 description 6
- 238000011049 filling Methods 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000037040 pain threshold Effects 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 239000009916 yin-huang Substances 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 5
- 229960001138 acetylsalicylic acid Drugs 0.000 description 5
- 230000003712 anti-aging effect Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 230000001502 supplementing effect Effects 0.000 description 5
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000004856 capillary permeability Effects 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 239000012362 glacial acetic acid Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000004899 motility Effects 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 206010010356 Congenital anomaly Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 description 3
- 206010059013 Nocturnal emission Diseases 0.000 description 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 3
- 240000005809 Prunus persica Species 0.000 description 3
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 210000000683 abdominal cavity Anatomy 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 230000013872 defecation Effects 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 210000004696 endometrium Anatomy 0.000 description 3
- 239000002662 enteric coated tablet Substances 0.000 description 3
- 229960004766 estradiol valerate Drugs 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 3
- 229960000907 methylthioninium chloride Drugs 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 239000004570 mortar (masonry) Substances 0.000 description 3
- 230000000422 nocturnal effect Effects 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 210000003371 toe Anatomy 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
- 235000017491 Bambusa tulda Nutrition 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 240000005561 Musa balbisiana Species 0.000 description 2
- 244000082204 Phyllostachys viridis Species 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- 206010041497 Spermatorrhoea Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- 230000000146 antalgic effect Effects 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000010977 jade Substances 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 230000001151 other effect Effects 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 230000004304 visual acuity Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000830535 Ligustrum lucidum Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 230000010718 Oxidation Activity Effects 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000003679 aging effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000009193 crawling Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 108010084652 homeobox protein PITX1 Proteins 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000037195 reproductive physiology Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 239000011122 softwood Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000009530 yishen Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medicine and health foods for alleviating menstrual period pain, the Chinese medicine and health food is mainly made of 1~10 part of raspberry, 1~8 part of nutmeg, 1~8 part of mulberries, 1~8 part of peach kernel, 1~6 part of rhizoma polygonati, 1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and 1~4 part of Radix Glycyrrhizae, and the water extract or alcohol extract of above-mentioned each raw material form Chinese materia medica preparation as active ingredient and appropriate additives.Chinese medicine and health food of the invention is in good taste, safely and effectively, most of crowds is suitble to be used for a long time；Raw material all derives from the Chinese medicine or natural food of integration of drinking and medicinal herbs, no ill-effect.The Chinese medicine and health food has the effect of significantly alleviating menstrual period pain, can lead to regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing analgesic, warming channel and expelling cold, adjust endocrine, be suitable for numerous women, be also applied for other sub-health populations.Prescription of the invention can be relieved the unsmooth card of qi and blood caused by blood element lose and various diseases, prevent anxiety, prevent early ageing, regulate and control human body physiological function.
Description
Technical field
The invention belongs to food technology fields, particularly relate to a kind of Chinese medicine and health food for alleviating menstrual period pain.
Background technique
Menstruation is the normal physiological phenomena of Women of childbearing age, is Human Physiology development as a result, its appearance indicates women
The preliminary maturation of reproductive physiology function, has the primary condition bred.The generation of primary dysmenorrhea removes constitution, mental element
Outside, mainly related with Prostaglandin PGF2 alpha too high levels in patient's secretory endometrium.PGF2 α is under progestogen action
Secretory endometrium in synthesis, for receptor in uterine muscular, menstrual endometrium is broken, and PGF2 α is released,
Uterus muscle strong contraction is stimulated, intra-uterine pressure is increased, local blood flow is reduced, ischemic, anoxic, so as to cause pain.
Dysmenorrhea is common disease, frequently-occurring disease in clinical gynaecology, belongs to inferior health scope.The generation of dysmenorrhea appoints with punching, uterus
Cyclical physiological variation is closely related, and main pathogenesis is in perverse trend that volt or essence or blood element lose, rushes wantonly two arteries and veins gas before and after more value menstrual period
The physiological change of blood is hurried, causes the QI-blood circulation of uterus unsmooth, and general rule pain or uterus do not lose in supporting, not Rong Ze pain, therefore make
Dysmenorrhea breaking-out.Common parting has the card such as kidney qi loss, deficient qi and blood, qi depression to blood stasis, cold blood stasis and damp-heat accumulation, suitable apparatus
There are the Chinese medicine or Chinese prescription of logical regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing analgesic, warming channel and expelling cold and other effects.
Traditional Chinese medicine thinks that the kidney being the origin of congenital constitution, and is the root of organ yin-yang, and kidney controlling essence storage, kidney essense evaporates kidney by kidney yang
Yin generates kidney qi, and kidney qi can subsidize, promote, coordinating the yin-yang of whole body internal organs, and determines the growth of human body, development, reproduction, declines
Old and dead life process.The growth and development of each process or warp, band, tire, the production of fail situation, especially women etc. are special
Physiology course it is normal whether, both depend on the prosperity and decline profit and loss of kidney essense and kidney qi.Theory of traditional Chinese medical science thinks, congenital deficiency of kidney-QI, or
Sexual strain fecund or prolonged illness are deficient, injure kidney qi, and then essence loses that blood is few, and deficiency is appointed in punching, is let out through promoting circulation of blood, and vessels of the uterus is more empty to kidney deficiency, lose in moistening
It supports, not Rong Ze pain, therefore makes dysmenorrhea.It therefore, all should be in terms of tonic kidney essense kidney qi to alleviate menstrual pain, prevention early ageing etc.
Start with conditioning.
Currently, the chemicals and biological products of commercially available menstruction regulating and pain relieving class point inhibit PGF2 α synthesis class (to belong to antipyretic-antalgic
Class drug), uterine leio muscular relaxation class and adjust vegetative nerve class, brufen, paracetamol, Semen daturae tablet, hydrobromic acid mountain
Scopolic acid, oryzanol etc. have preferable effect in anti-inflammatory and antalgic and in terms of eliminating menstrual dysphoria, but occur many bad anti-
It answers, such as constipation, interference sleep, dry skin, causes clinical application limited.Chinese traditional medicine is paid attention to transferring human body itself
Immunity adjusts human endocrine system, has advantageous advantage in terms of fighting dysmenorrhea, preventing anxiety and anti-aging, together
When have safely and effectively, the small feature of toxic side effect.If it is possible to develop, one kind is small with toxic side effect, curative effect is good
It gets well, can take for a long time, will have huge market to send out with the Chinese medicine and health food for alleviating menstrual pain, prevention early ageing and other effects
Open up potentiality.
Summary of the invention
The present invention provides a kind of Chinese medicine and health food for alleviating menstrual period pain to overcome the shortcomings of the prior art.
The present invention is achieved by the following technical solutions: a kind of Chinese medicine and health food for alleviating menstrual period pain, the alleviation
The Chinese medicine and health food of menstrual period pain is mainly made of the raw material of following parts by weight: 1~10 part of raspberry, 1~8 part of nutmeg,
1~8 part of mulberries, 1~8 part of peach kernel, 1~6 part of rhizoma polygonati, 1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and 1~4 part of Radix Glycyrrhizae, the alleviation warp
The Chinese medicine and health food of phase pain by above-mentioned each raw material water extract or alcohol extract as active ingredient with it is pharmaceutically acceptable
Appropriate additives form Chinese materia medica preparation.
As the preferred embodiment of the present invention, the present invention alleviates the Chinese medicine and health food of menstrual period pain mainly by following heavy
Measure the raw material composition of part: 4~8 parts of raspberry, 3~5 parts of nutmeg, 3~5 parts of mulberries, 3~5 parts of peach kernel, 2~4 parts of rhizoma polygonati, jade
2~4 parts of bamboo, 2~4 parts of Gorgon fruit and 1~3 part of Radix Glycyrrhizae.
As preferred forms of the invention, the present invention alleviates the Chinese medicine and health food of menstrual period pain mainly by following heavy
Measure part raw material composition: 6 parts of raspberry, 4 parts of nutmeg, 4 parts of mulberries, 4 parts of peach kernel, 3 parts of rhizoma polygonati, 3 parts of radix polygonati officinalis, 3 parts of Gorgon fruit and
2 parts of Radix Glycyrrhizae.
The dosage form of Chinese materia medica preparation is granule or mixture.Additives are in dietary supplement, preservative and filler
One or more mixtures being mixed in any proportion.Dietary supplement is minerals, vitamin, natto, plant
Any one in object protein powder or two kinds of mixtures being mixed in any proportion.
Minerals are one of selenium, zinc, calcium, magnesium, potassium, iron, chromium, manganese or a variety of mixing being mixed in any proportion
Object；Vitamin is one of beta carotene, vitamin B1, vitamin B6, vitamin C, vitamin D, vitamin E or a variety of
The mixture being mixed in any proportion；Plant protein powder is soybean protein isolate, lactalbumin, pea protein, collagen
One of albumen or a variety of mixtures being mixed in any proportion.
Filler is to meet common medicinal supplementary material as defined in " Chinese Pharmacopoeia " pharmaceutic adjuvant standard, includes but are not limited to second
Alcohol, dextrin, starch, sucrose, glucose, honey, mannitol, xylitol, Steviosin, lactose, fructose, protein sugar, maltitol,
One of Aspartame, flavoring banana essence, flavoring pineapple essence, vanillic aldehyde, fragrant citrus essence, Mint Essence and citric acid are a variety of to appoint
The mixture that meaning ratio mixes, can be used alone, and also can be used in combination.
Preservative is to meet common medicinal supplementary material as defined in " Chinese Pharmacopoeia " pharmaceutic adjuvant standard, is included but are not limited to thin
Lotus oil, cinnaldehydrum, eucalyptus oil, benzoic acid, sodium benzoate, methylparaben, ethylparaben, propylben, nipalgin fourth
One of ester and sorbic acid or a variety of mixtures being mixed in any proportion, can be used alone, also can be used in combination.
The present invention alleviate menstrual period pain Chinese medicine and health food preparation method be by by raspberry, nutmeg, mulberries,
The raw material that peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae form is processed into intermediate raw material by extraction or other modes, when needing
Pharmaceutically acceptable additives are added, are made according to the routine techniques of galenic pharmacy.Intermediate raw material is obtained by extracting raw material respectively
It obtains to or by extracting raw material jointly, can also obtain by other means, such as crush, squeeze, being ground up, sieved, diacolation, extraction
Take, water mentions, alcohol extracting, ketone the methods of are mentioned, chromatographed and obtains, these intermediate raw materials can be medicinal extract form, can be dry extract, can also
To be liquid extract, different according to preparation need to determine that different concentration is made.
The present invention is according to theory of traditional Chinese medical science reasonable compatibility raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and sweet
The medicinal material of 8 kinds of integration of drinking and medicinal herbs such as grass.Prescription has logical regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing analgesic, warming channel and expelling cold effect, can be relieved
The unsmooth card of qi and blood caused by blood element lose and various diseases alleviates menstrual period pain, prevents anxiety, prevents early ageing, regulates and controls human body
Physiological function.Raspberry in the present invention invigorates the kidney and stops nocturnal emission establishing-Yang reducing urination, nourishes the liver to improve visual acuity as monarch drug in a prescription.Rhizoma polygonati, radix polygonati officinalis boosting qi and nourishing yin profit
Lung, Yishen Jianpi promote the production of body fluid to quench thirst as ministerial drug.Peach kernel promoting blood circulation, relax bowel and defecation；Gorgon fruit tonifying spleen clearing damp, supplementing the kidney to control the nocturnal；Mulberries are grown
Yin is enriched blood, and ease constipation is promoted the production of body fluid；Three is adjutant altogether.All the medicines share, and play kidney and spleen invigorating altogether, nourishing heart tonifying liver, QI invigorating righting is to dispel
Heresy, eliminating evil go just not hurt, and heresy removes the just disease amelioration or even to more from peace.It there is no identical as the present invention group in currently available technology
The document report of side and its preparation.
Raspberry: it is sweet can help, acid can restrain, warm-natured without scorching, kidney-replenishing and the disadvantage without impairment of yin, prevent prolapse and without sluggish
Evil, beneficial to the function of lower envelope hiding, be apt to control the card of kidney deficiency not admittedly and mending can be solid.Representative medicine of the raspberry as the establishing-Yang that invigorates the kidney and stops nocturnal emission,
Clinically it is usually used in treating neurasthenia, emission and spermatorrhea, premature ejaculation impotence, enuresis frequent micturition, consumptive disease, mesh is secretly dim-sighted to wait card.Pharmacology
It is demonstrated experimentally that raspberry has anti-mutagenesis, anti-inflammatory, anti-oxidant, improving studing ability, anti-aging and enhances immune etc. make
With.
Nutmeg: acrid flavour, it is warm-natured.Returns spleen, stomach, large intestine channel.Middle benefit gas promoting the circulation of qi, relieving diarrhea with astringents.For deficiency-cold in spleen and stomach, chronic diarrhea is not
Only, abdominal distention, deficiency of food vomiting." materia medica ": nutmeg, except cold eliminating dampness, taste are specially managed in promoting the circulation of qi of unhitching.
Mulberries: it is sweet in flavor, it is cold in nature.Return heart, liver and kidney channel.With nourishing yin and supplementing blood, ease constipation, the effect of promoting the production of body fluid.For yin deficiency blood
Void, the deficiency of Yin are quenched one's thirst, and body fluid deficiency is thirsty, dizziness and tinnitus, dry constipation of intestines.For dizziness caused by the yin deficiency deficiency of blood, tinnitus, mesh be dark, insomnia,
Poliosis is ground honeyed bolus processed with this product and is taken；Also can with the Chinese medicines such as the fleece-flower root, the fruit of glossy privet with using, the benefits of to enhance nourishing yin and supplementing blood,
Such as Shouwuyishoudan.
Peach kernel: bitter, it is mild-natured.Return heart, liver, lung, large intestine channel.With promoting blood circulation, the effect of relax bowel and defecation.For passing through
It closes, dysmenorrhea, postpartum stasis, injuries from falls as well, pulmonary abscess, acute appendicitis, dry constipation of intestines.For amenorrhea due to stagnation of blood, dysmenorrhea, often with safflower,
Radix Angelicae Sinensis, Chinese herbaceous peony are equally used, such as peach blossom Siwu Tang；For postpartum stasis abdominal pain, it can be equal with Radix Angelicae Sinensis, Rhizoma Chuanxiong, baked ginger and use, it is such as biochemical
Soup.
Rhizoma polygonati: it is sweet in flavor, it is mild-natured.Returns spleen, lung, kidney channel.With boosting qi and nourishing yin, the effect of invigorating the spleen, moistening lung, kidney-nourishing.For controlling
Treat deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, palpus
Hair is early white, the card such as Heat Diabetes, is one of common nourishing drug of Chinese medicine.Modern research shows that rhizoma polygonati has resisting pathogenic microbes
Such as bacterium, fungi, virus, reducing blood lipid is hypoglycemic, blood pressure lowering, and anti-aging is antitumor, antifatigue, anti-radiation, resist oxygen lack, resists
Oxidation activity, enhancing is immune, and immune enhancing is the decline of the leucocyte due to caused by antagonism cyclophosphamide, and strong neutrophil gulps down
The effects of effect of biting, coronary artery dilator, increase coronary blood flow.
Radix polygonati officinalis: Shennong's Herbal is classified as top grade.It is sweet in flavor, cold nature.It attaches to the lung and stomach meridians.With nourishing yin to moisten dryness, promote the production of body fluid to quench thirst
The effect of.For treating lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, the card such as Heat Diabetes.Modern research shows that radix polygonati officinalis has
The effects of raising immunity, heart tonifying is hypoglycemic, reducing blood lipid, extends animal lifespan.
Gorgon fruit: it is sweet, puckery, it puts down.Returns spleen, kidney channel.With tonifying spleen clearing damp, the effect of supplementing the kidney to control the nocturnal.For splenasthenic diarrhea, kidney deficiency
Spermatorrhea, leukorrhagia.Gorgon fruit can be used together, such as yihuang decoction for controlling under humid tropics with heat-clearing and diuresis-promoting drugs such as Cortex Phellodendri, semen plantaginis；For spleen
The leukorrhagia of two void of kidney is mostly used together with reinforcing spleen and kidney medicines such as Radix Codonopsis, Rhizoma Atractylodis Macrocephalaes.
Radix Glycyrrhizae: sweet natured, return heart, spleen, lung, stomach meridian.With invigorating the spleen and benefiting qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain
The effect of, and can coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction are suddenly ached
Bitterly, carbuncle sore tumefacting virus alleviates the strong property of drug poison.
The beneficial effects of the present invention are: the present invention is based on the given efficacy of each natural plants and pharmaceutical values, with nature
Plant combines traditional health-preserving method with theory of medicine, is conceived to and alleviates menstrual period pain, anti-inflammatory and antalgic, adjusts endocrine
Deng by the plant optimization compounding of 8 kinds of integration of drinking and medicinal herbs such as raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae.
On the one hand, lead to regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, nourish body, it is empty must mend, canonical it is prosperous, immunity enhance；On the other hand, blood-nourishing analgesic,
Warming channel and expelling cold, palace is supported, ovary obtains warm, anti-aging.Congenital deficiency of kidney-QI or sexual strain fecund or prolonged illness are deficient, injure kidney
Gas, then essence loses that blood is few, and vessels of the uterus loses in supporting, therefore has dysmenorrhea to kidney deficiency.Chinese prescription of the invention can be relieved blood element lose and various
The unsmooth card of qi and blood caused by disease prevents anxiety, prevents early ageing, regulates and controls human body physiological function.
The present invention also provides a kind of Chinese medicine and health foods in terms of alleviating menstrual period pain, improving energy, anti-aging
Purposes.Raspberry in the present invention invigorates the kidney and stops nocturnal emission establishing-Yang reducing urination, nourishes the liver to improve visual acuity as monarch drug in a prescription.Rhizoma polygonati, radix polygonati officinalis boosting qi and nourishing yin moistening lung, benefit
Kidney and strengthening spleen promotes the production of body fluid to quench thirst as ministerial drug.Peach kernel promoting blood circulation, relax bowel and defecation；Gorgon fruit tonifying spleen clearing damp, supplementing the kidney to control the nocturnal；Mulberries enriching yin is mended
Blood, ease constipation are promoted the production of body fluid；Three is adjutant altogether.All the medicines share, and play kidney and spleen invigorating altogether, nourishing heart tonifying liver, QI invigorating righting with eliminating evil,
Eliminating evil goes just not hurt, and heresy removes the just disease amelioration or even to more from peace.
The Chinese medicine and health food that the present invention alleviates menstrual period pain also has the advantage that in good taste, safely and effectively, is suitble to big
Most crowds are used for a long time；Raw material all derives from integration of drinking and medicinal herbs Chinese medicine or natural food, safely and effectively, no ill-effect, nutrition
Comprehensively.The Chinese medicine and health food has the effect of significantly alleviating menstrual period pain, can lead to regulating the qi flowing in the channels blood, kidney tonifying, essence replenishing, blood-nourishing stop
Bitterly, warming channel and expelling cold, endocrine function is adjusted, is suitable for numerous women, is also applied for other sub-health populations.The present invention, which uses, to be covered
Basin, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and the extract mixtures of Radix Glycyrrhizae as raw material, be made granule or
Mixture, the granule or mixture have according to Basic Theories of Chinese Medicine prescription and alleviate menstrual period pain, adjust endocrine health care function
Can, can enriching yin and nourishing kidney, QI invigorating analgesia, menstruction regulating and pain relieving.The present invention has apparent remission effect, nothing to dysmenorrhea caused by estrogen
Obvious adverse reaction, no dependence, simple process is easy, and production cost is low, is conducive to industrialized production, can be made as needed
A variety of dosage forms.
Detailed description of the invention
Fig. 1 is schematic diagram of the granule to the analgesic activity of hot plate method induced pain mouse；
Fig. 2 is schematic diagram of the granule to the analgesic activity of glacial acetic acid induced pain mouse；
Fig. 3 is the linear dependence figure between absorbance A value and Evans blue seepage discharge；
Fig. 4 is the schematic diagram of influence of the granule to mouse capillary permeability；
Fig. 5 is that granule influences schematic diagram to mouse toes swelling；
Fig. 6 is influence schematic diagram of the granule to uterus activity ratio；
Fig. 7 is the linear dependence figure between absorbance OD value and β-ep amount；
Fig. 8 is influence schematic diagram of the granule to female mice β-ep content.
Specific embodiment
Below in conjunction with specific embodiment, present invention is further described in detail.
A kind of Chinese medicine and health food for alleviating menstrual period pain, the Chinese medicine and health food of the alleviation menstrual period pain is mainly by following
The raw materials of parts by weight forms: 1~10 part of raspberry, 1~8 part of nutmeg, 1~8 part of mulberries, 1~8 part of peach kernel, 1~6 part of rhizoma polygonati,
1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and 1~4 part of Radix Glycyrrhizae；The present invention alleviates the Chinese medicine and health food of menstrual period pain by above-mentioned each original
The water extract or alcohol extract of material form Chinese materia medica preparation, Chinese materia medica preparation as active ingredient and pharmaceutically acceptable appropriate additives
Dosage form be granule or mixture.
As the preferred embodiment of the present invention, the present invention alleviates the Chinese medicine and health food of menstrual period pain mainly by following heavy
Measure the raw material composition of part: 4~8 parts of raspberry, 3~5 parts of nutmeg, 3~5 parts of mulberries, 3~5 parts of peach kernel, 2~4 parts of rhizoma polygonati, jade
2~4 parts of bamboo, 2~4 parts of Gorgon fruit and 1~3 part of Radix Glycyrrhizae.
As preferred forms of the invention, the present invention alleviates the Chinese medicine and health food of menstrual period pain mainly by following heavy
Measure part raw material composition: 6 parts of raspberry, 4 parts of nutmeg, 4 parts of mulberries, 4 parts of peach kernel, 3 parts of rhizoma polygonati, 3 parts of radix polygonati officinalis, 3 parts of Gorgon fruit and
2 parts of Radix Glycyrrhizae.
Additives are one of dietary supplement, preservative and filler or a variety of are mixed in any proportion
Mixture.Dietary supplement be minerals, vitamin, natto, any one or two kinds in plant protein powder with
The mixture that arbitrary proportion mixes.Minerals are one of selenium, zinc, calcium, magnesium, potassium, iron, chromium, manganese or a variety of with any
The mixture that ratio mixes；Vitamin is beta carotene, vitamin B1, vitamin B6, vitamin C, vitamin D, dimension
One of raw element E or a variety of mixtures being mixed in any proportion；Plant protein powder is soybean protein isolate, whey
One of albumen, pea protein, collagen or a variety of mixtures being mixed in any proportion.Filler is to meet
Common medicinal supplementary material as defined in " Chinese Pharmacopoeia " pharmaceutic adjuvant standard, includes but are not limited to ethyl alcohol, dextrin, starch, sucrose, Portugal
Grape sugar, honey, mannitol, xylitol, Steviosin, lactose, fructose, protein sugar, maltitol, Aspartame, flavoring banana essence, spinach
One of trailing plants essence, vanillic aldehyde, fragrant citrus essence, Mint Essence and citric acid or a variety of mixing being mixed in any proportion
Object can be used alone, and also can be used in combination.Preservative be meet commonly used as defined in " Chinese Pharmacopoeia " pharmaceutic adjuvant standard it is medicinal auxiliary
Material, include but are not limited to peppermint oil, cinnaldehydrum, eucalyptus oil, benzoic acid, sodium benzoate, methylparaben, ethylparaben,
One of propylben, butyl hydroxybenzoate and sorbic acid or a variety of mixtures being mixed in any proportion, can be independent
It uses, also can be used in combination.
Embodiment 1: mixture.
Formula: raspberry 60g, nutmeg 40g, mulberries 40g, peach kernel 40g, rhizoma polygonati 30g, radix polygonati officinalis 30g, Gorgon fruit 30g, sweet
Careless 20g and sodium benzoate 0.6g.
Preparation method: taking raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae, adds water to cook 3 times,
Each 2h, first time amount of water are 12 times of above-mentioned raw materials total amount, after twice amount of water be 10 times of above-mentioned raw materials total amount.It collects
Extracting solution, filtration merge 3 extracting solutions, and filtrate is concentrated into a certain concentration, is cooled to room temperature, and are slowly added to mass concentration
For 95% ethyl alcohol and quickly stir, make alcohol content 75%, 12h is placed in sealing, is centrifuged to obtain supernatant, and additives, constant volume is added
At certain volume, filtration, packing, sterilizing.
Embodiment 2: granule.
Formula: raspberry 50g, nutmeg 30g, mulberries 40g, peach kernel 40g, rhizoma polygonati 30g, radix polygonati officinalis 30g, Gorgon fruit 20g, sweet
Careless 10g, dextrin 40 g, sucrose 80g and 80% ethyl alcohol 10mL.
Preparation method: taking raspberry, nutmeg, mulberries, peach kernel, rhizoma polygonati, radix polygonati officinalis, Gorgon fruit and Radix Glycyrrhizae, adds water to cook 3 times,
Each 2h, each amount of water are 10 times of above-mentioned raw materials total amount.Extracting solution is collected, filtration merges extracting solution three times, filtrate
It is concentrated into a certain concentration, is cooled to room temperature, the ethyl alcohol that mass concentration is 95% is slowly added to and is quickly stirred, alcohol content is made
80%, 12h is placed in sealing, is centrifuged to obtain supernatant, is dried under reduced pressure through 60 DEG C to dry cream, is crushed, additives are added, mix, crosses 80 mesh
Sieve, using dry granulation, uniformly sprays into suitable 80% ethyl alcohol, and hand is made and pinches the i.e. scattered softwood of agglomerating, finger pressure, then with extruding
Mode is sieved by 10 mesh medicines, and uniform particle is made, is rapidly placed in the particle being prepared into 60 DEG C of baking oven, dry 3h.It takes
Dry particle carries out whole grain, packing with 10 meshes and 65 meshes.
Embodiment 3: mixture.
Formula: raspberry 60g, nutmeg 40g, mulberries 30g, peach kernel 30g, rhizoma polygonati 30g, radix polygonati officinalis 20g, Gorgon fruit 20g, Radix Glycyrrhizae
15g and ethylparaben 0.5g.The preparation method is the same as that of Example 1.
Embodiment 4: granule.
Formula: raspberry 70g, nutmeg 40g, mulberries 40g, peach kernel 20g, rhizoma polygonati 20g, radix polygonati officinalis 30g, Gorgon fruit 15g, sweet
Careless 15g, dextrin 90g, Steviosin 0.04g and 80% ethyl alcohol 10mL.Preparation method is the same as embodiment 2.
Chinese materia medica preparation in the present invention can alleviate menstrual period pain, delay senescence, and keep or enhance ovarian function, anti-inflammatory
The effect of analgesia, can be proved by following four pharmacodynamic experiment:
Experiment I: the analgesic experiment of hot plate method and writhing method；
Experiment II: the anti-inflammatory experiment of mice caused by dimethylbenzene xylene auricle edema method and the test of carrageenan induced mice pedal swelling；
Experiment III: uterine contraction experiment；
Test IV: serumβ-ep horizontal measurement experiment.
The specific implementation method respectively tested is as follows:
1. experimental material.
1.1, laboratory sample and reagent.
Bolus for woman diseases (Shanxi Guang Yuyuan traditional Chinese medicines Co., Ltd, lot number: 139170102)；Aspirin enteric coated tablet (Bayer medicine
Healthcare Corporation, lot number: BJ32400)；Yinhuang Particle (Hengsheng Pharmaceutical Co., Ltd., Zhongshan City, lot number: 20161007)；Penta
Sour estrogen tablet (DELPHARM Lille S.A.S, lot number H20160679)；The Tianjin NaCl(causes the remote limited public affairs of chemical reagent
Department, lot number: 20160710)；Evans blue (Shanghai Ru Ji biotechnology Development Co., Ltd, lot number: 150722)；Carrageenan
(Shanghai Mike's woods biochemical technology Co., Ltd, lot number: C10068972)；Methylene blue (the limited public affairs of Chinese medicines group chemical reagent
Department, lot number: 20151223)；Mouse β-ep kit (Tianjin An Nuoruikang Bioisystech Co., Ltd).
1.2, experimental animal.
SPF Kunming mice, male and female dual-purpose, 18~22g of weight are mentioned by Nanfang Medical Univ's Experimental Animal Center
For the Guangdong production licence number SCXK() 2016-0041, Guangdong pharmaceutical university Experimental Animal Center raising experiment.According to experimental
Matter and gender divide cage to feed, and drinking-water is freely eaten, weighs in every other day.22~24 DEG C of room temperature, relative humidity 52%~56%.
1.3, instrument and producer.
BP211D type a ten thousandth electronic balance (Mei Tele-support benefit Instrument Ltd.)；KQ-300DE numerical control ultrasound
Washer (Kunshan Ultrasonic Instruments Co., Ltd.)；(Community of Jin Tan County Jin Cheng state wins laboratory apparatus to six hole water-bath of HH-S6 constant temperature
Factory)；YLS-6B intelligence hot-plate instrument (Beijing Zhong Shidichuan development in science and technology Co., Ltd)；Top Pette8-Channer
The Pipettor liquid relief volley of rifle fire (the emerging wound laboratory apparatus Beijing Co., Ltd of big dragon)；MNT-150 Mei Naite origin digital display calliper (Shanghai
Mei Naite Industrial Co., Ltd.)；Thermo Scientific Multiskan Spectrum microplate reader (the silent winged generation that China of match
Co., Ltd)；Thermo Scientific HERA cell CO2 cell incubator (Co., Ltd in the silent winged generation that of match)；
BL-420F biological signal collecting and analysis system (Chengdu TME Technology Co., Ltd.)；FT-102N has calibrated tension sensor
(Chengdu TME Technology Co., Ltd.).
1.4, the preparation of sample.
Body weight in terms of 60kg, mouse daily dose in terms of 9 times of people, the mouse dosage of positive control drug with
0.2mL/10g meter, the mouse dosage of tested granule particle is in terms of 0.3mL/10g.Sample is specifically formulated as follows:
1. given the test agent is prepared: (50~60 DEG C) of physiological saline dissolutions are added in the granule being prepared into Example 2, necessary
Shi Jinhang ultrasonic treatment, is configured to the suspension of basic, normal, high three kinds of concentration (100mg, 150mg, 225mg:1mL).
2. the preparation of Yinhuang Particle sample (60mg:1mL): Yinhuang Particle mortar being ground in after powder, 6g is weighed and adds
Physiological saline is to 100mL, prepared before use.
3. the preparation of aspirin enteric coated tablet sample (4.5mg:1mL): it is in powder that aspirin enteric coated tablet mortar, which is ground,
It is last, it weighs 0.45g and adds physiological saline to 100mL, be ultrasonically treated when necessary, prepared before use.
4. the preparation of bolus for woman diseases sample (81mg:1mL): bolus for woman diseases mortar being ground in after powder, 3.24g is weighed and adds
(50~60 DEG C) physiological saline is ultrasonically treated, prepared before use to 40mL.
5. the preparation of Estradiol Valerate sample (0.04mg:1mL): a piece of estradiol valerate tablet (1mg/ piece) being taken to be dissolved in
In 25ml physiological saline, prepared before use.
6. 0.8% acetum: the glacial acetic acid of accurate measuring 0.8mL adds distilled water constant volume into the volumetric flask of 100mL, faces
With preceding preparation.
7. 0.5% Evans blue physiological saline: weighing 0.5g Evans blue powder and be completely dissolved in 100mL physiological saline, pass through
0.22 μm of miillpore filter filtration, prepared before use.
8. 0.8% acetic acid physiological saline: the glacial acetic acid of accurate measuring 0.8mL adds physiological saline constant volume to the volumetric flask of 100mL
In, prepared before use.
9. 1% carrageenan suspension: weighing 50mg carrageenan powder for 24 hours before use and be dissolved in 50mL physiological saline, repeatedly
Shaking is ultrasonically treated when necessary to no indissoluble object gel, is placed in 4 DEG C of preservations.
10. 5% methylene blue solution: weighing 0.5g methylene blue powder and be completely dissolved in the second that the mass concentration of 100mL is 95%
Alcoholic solution, prepared before use.
2.1, experiment I: the analgesic experiment of mouse.
2.1.1, hot plate method；
Female mice 75 are taken, intelligent hot-plate instrument temperature is adjusted to (55 ± 0.5) DEG C, it is after preheating 10min, female mice is each
1 is merely placed on hot plate, and mouse licks the pain threshold of (s) as the mouse the time required to left back foot from putting to occurring, and screening is qualified
(female mice 75 for licking the sufficient time in 5s to 30s) is only divided into 5 groups by table of random number, every group 15, respectively physiological saline
Group (0.2 mL/10g), aspirin positive controls, granule low dose group, middle dose group and high dose group.Every group of administration
Preceding replication pain threshold, take twice threshold of pain average value as normal pain threshold.After adaptable fed 3 days, by different groups into
Row relative medicine stomach-filling claims time weight 1 time a day every other day, according to weight by being only administered, successive administration 5 days.Divide after the last administration
Not in the pain threshold of 0.5h, 1h, 2h and 3h measurement mouse, if being taken out immediately in mouse 60s without pain reaction, calculated by 60s,
Record improves percentage as a result, calculating each group threshold of pain, as a result carries out t between group with SPSS22 and examines, is to have statistics with P < 0.05
Meaning.
2.1.2, writhing method:
Mouse 75 are taken, half male and half female is divided into 5 groups by table of random number, every group 15, respectively physiological saline group (0.2mL/
10g), aspirin positive controls, granule low dose group, middle dose group, high dose group.After adaptable fed 3 days, by not
Relative medicine stomach-filling is carried out with group, 1 time a day, claims time weight every other day, according to weight by being only administered, successive administration 5 days.In
30min after the last administration, each mouse are injected intraperitoneally 0.6% acetum newly prepared by the dosage of 0.1ml/10g, observe and record
There is the number of writhing response (abdomen shrinks indent, stretches hind leg, and buttocks is raised, crawling) in every mouse in 15min, calculates town
As a result pain percentage carries out t between group with SPSS22 and examines, be statistically significant with P < 0.05.
Analgesia percentage (%)=(saline control group be averaged writhing number-administration group be averaged writhing number)/physiology salt
Water control group is averaged writhing number × 100%.
2.2, experiment II: the anti-inflammatory experiment of mouse.
2.2.1, mouse peritoneal capillary permeability is tested:
Healthy Kunming mouse (18~22 g) 90 is taken, half male and half female is divided into 6 groups, every group 15 by table of random number.Respectively
For normal group (0.2 mL/10 g of physiological saline), model group (0.2 mL/10 g of physiological saline), Yinhuang Particle group, granule
Grain low, middle and high dose groups.After adaptable fed 3 days, relative medicine stomach-filling is carried out by different groups, 1 time a day, is claimed every other day secondary
Weight, according to weight by being only administered, successive administration 10 days.Fasting 12h before last time is administered, after last dose 30min, respectively
The equal 0.5% Evans blue physiological saline 0.1ml/10g (filtering through miillpore filter) of tail vein injection of mouse, gently rubs abdomen, immediately abdominal cavity
Inject 0.8% acetic acid physiological saline 0.2ml/10g(and normally organize and do not inject acetic acid as control), take off after 30min neck put to death it is each small
Mouse splits abdominal cavity, with 5ml normal saline flushing number, collects washing lotion and is settled to 10mL, 3000r/min is centrifuged 20min, takes
Clear liquid measures trap (OD value) with ultraviolet specrophotometer with physiological saline school zero at 590nm, as a result with SPSS22 into
T is examined between row group, is statistically significant with P < 0.05.
In addition, releasing azovan blue concentration according to absorbance A value, method: the log10 dilution of 0.5% azovan blue solution is done
And in colorimetric surveys absorbance A value at 590nm on spectrophotometer, it is known that concentration mensuration point replication 2 times, mean value is as A
Value, seeks the linear dependence between A value and seepage discharge (μ g/mL), finds out the other Evans blue seepage discharge of each group.Administration group suppression
Rate (%) processed=(model group absorbance values-administration group absorbance values)/model group absorbance values × 100%.
2.2.2, carrageenan induced mice pedal swelling is tested:
Mouse 90 are taken, half male and half female is divided into 6 groups by table of random number, every group 15, respectively blank group (physiological saline 0.2
ML/10 g), model group (0.2 mL/10 g of physiological saline), aspirin group, granule low dose group, middle dose group and high agent
Amount group.After adaptable fed 3 days, relative medicine stomach-filling is carried out by different groups, 1 time a day, claims time weight every other day, according to weight
By being only administered, successive administration 10 days.All mouse left hind vola pedis first are surveyed with vernier caliper (precision 0.02mm) after the last administration
Thickness, 1% carrageenan suspension (every 0.02mL) then is subcutaneously injected at left hind vola pedis, it is raw that blank group injects equivalent
Salt water is managed, acute pedal swelling model is caused.30min, 1h, 2h, 3h mouse cause after 1% carrageenan suspension of measurement injection respectively
The thickness of vola pedis after after inflammation, so that the difference of vola pedis thickness and the thickness of the scorching front and back vola pedis of cause is as swelling after inflammation, with swelling
As Testing index, statistical analysis is carried out, investigates the influence of drug Carrageenan induced mice pedal swelling.It is secondary after cause is scorching
Day puts to death mouse, takes the rear vola pedis of mouse or so, is precisely weighed, and left and right vola pedis difference is inflammatory swelling degree, and it is swollen to calculate mouse vola pedis
Swollen inhibiting rate.As a result t between group is carried out with SPSS22 to examine, be statistically significant with P < 0.05.
Following equation is shown in swelling rate and the calculating of pedal swelling inhibiting rate: swelling rate (%)=(thick before thickness-cause is scorching after cause is scorching
Degree)/cause thickness × 100% before inflammation.
2.3, test III: uterine contraction is tested.
2.3.1, uterine activity degree:
Female mice 90 are taken, is randomly divided into 6 groups, every group 15, respectively blank group (physiological saline 0.2mL/10g), model
Group (physiological saline 0.2mL/10g), bolus for woman diseases group, granule granule low dose group, middle dose group and high dose group.Adaptability
After feeding 5 days, relative medicine stomach-filling is carried out by different groups, presses 0.5mg/kg stomach-filling Estradiol Valerate after 6h, 1 time a day, every
It claims time weight, according to weight by being only administered, successive administration 15 days (3~4 periods).Indices are carried out by requirement of experiment
It investigates, t between group is as a result carried out with SPSS22 and is examined, be statistically significant with P < 0.05.
2.3.2, experiment is shunk in uterus automatically:
It plucks after eyeball takes blood and rapidly puts to death mouse, split abdominal cavity, take out uterus and two sides ovary, remove surrounding tissue and rouge
Fat separates side uterus, threads in 1cm on cornua uteri crotch, the free-end of line is connected on tension sensor, uses BL-
Contraction waveform after 420F biological signal collecting and analysis system record uterine contraction are stablized in 10min.Statistics is shunk the frequency, is received
Contracting intensity calculates uterine activity degree (the uterine activity degree=contraction frequency × contraction intensity).As a result t between group is carried out with SPSS22 to examine
It tests, is statistically significant with P < 0.05.
2.4, test IV: β-ep level detects in serum.
After last dose 1h, each group mouse takes blood with plucking eyeball method, after taken blood is stood 1h, centrifugation
(3000r/min, 10min) separates serum, operates according to kit specification.Measure the content of β-ep in mice serum.
β-ep ELISA (ELISA) specific steps are as follows:
1. the sample-adding of standard items: setting standard sample wells and sample well, standard sample wells respectively add the 50 μ L of standard items of various concentration.
2. sample-adding: be respectively set blank well (sample and enzyme marking reagent is not added in blank control wells, remaining each step operation is identical),
Sample to be tested hole.First add 40 μ L of sample diluting liquid in sample to be tested hole on enzyme mark coating plate, then again plus with 10 μ L of sample
(the final dilution of sample is 5 times).Sample is added on ELISA Plate hole bottom by sample-adding, is tried not to touch hole wall, be shaked gently mixed
It is even.
3. enzyme: every hole liquid relief volley of rifle fire adds 100 μ L of enzyme marking reagent, in addition to blank well.
4. incubating: using 37 DEG C of incubation 60min of sealing plate film sealing plate postposition.
5. matching liquid: spare after being diluted with 20 times 20 times of concentrated cleaning solution distilled water.
6. washing: carefully opening sealing plate film, discard liquid, dry, cleaning solution is filled it up in every hole, is discarded after standing 30 seconds, such as
This is repeated 5 times, and pats dry.
7. colour developing: every Kong Xianjia color developing agent A50 μ L, then plus color developing agent B50 μ L, gently concussion mix, 37 DEG C are protected from light colour developing
15min。
8. terminating: every hole adds 50 μ L of terminate liquid, terminates reaction.
9. measurement: being returned to zero with blank well, 450nm wavelength sequentially measures the Absorbance (OD) value in each hole.Measurement should add end
Only carried out in 15min after liquid.
10. calculating: using the concentration of reference substance as abscissa, OD value is abscissa, draws standard curve, obtains linear regression
Equation calculates corresponding concentration according to the OD value of sample, multiplied by extension rate, the as actual concentrations of sample.
3, experimental result and analysis.
3.1, Fig. 1 is in an embodiment of the invention, and granule shows the analgesic activity of hot plate method induced pain mouse
It is intended to.
As shown in Figure 1, granule (2.275,4.55,9.1g/kg) pain threshold improves percentage compared with physiological saline group
Difference is statistically significant (P < 0.01).I.e. granule can improve to some extent hot plate method pain model mouse pain threshold,
Pain reaction number is reduced, analgesic effect has apparent dose-effect relationship, and the analgesic activity of low dose group is worst.(note: with
Physiological saline group compares: P < 0.01 * P < 0.05, * *；Compared with aspirin group: ▲ P < 0.05, ▲ ▲ P < 0.01).
3.2, Fig. 2 is in an embodiment of the invention, and granule shows the analgesic activity of glacial acetic acid induced pain mouse
It is intended to.
As shown in Figure 2, granule (2.275,4.55,9.1g/kg) can reduce the writhing time of acetic acid induced pain mouse significantly
Number, it is statistically significant (P < 0.01) with physiological saline group comparing difference；Granule high dose group, middle dose group can different journeys
Degree ground extends the incubation period of writhing, statistically significant (P < 0.05 or P < 0.01) with physiological saline group comparing difference.From analgesia
Rate sees that analgesic effect has apparent dose-effect relationship.(note: compared with physiological saline group: P < 0.01 * P < 0.05, * *；With Ah
Department's woods group compares: ▲ P < 0.05, ▲ ▲ P < 0.01).
3.3, Fig. 3 to Fig. 4 is schematic diagram in an embodiment of the invention and granule to mice auricle swelling
Influence schematic diagram.Wherein, Fig. 3 is the linear dependence figure between absorbance A value and Evans blue seepage discharge (μ g/mL),
Influence schematic diagram of Fig. 4 granule to mouse capillary permeability.
As shown in Figure 4, granule low, middle and high dose groups can reduce mouse capillary permeability, reduce peritoneal fluid
Exudation, have apparent anti-inflammatory effect, anti-inflammatory effect and model group comparing difference it is statistically significant (P < 0.01).Granule
Middle dose group, high dose group and Yinhuang Particle group comparing difference are not statistically significant (P > 0.05).In terms of inhibiting rate, granule is low
The inhibiting rate of dosage group is worst, but without apparent dose-effect relationship between low middle high dose group.(note: compared with blank group: * P <
0.05, **P<0.01；Compared with Yinhuang Particle group: ▲ P < 0.05, ▲ ▲ P < 0.01；Compared with model group: ▼ P < 0.05, ▼
P < 0.01 ▼).
3.4, Fig. 5 is the schematic diagram of influence of the granule to mouse toes swelling in an embodiment of the invention.
As shown in Figure 5, injection carrageenan causes 30min after inflammation, and granule each group and model group comparing difference are without statistics
It learns meaning (P > 0.05)；1h after cause is scorching, granule high dose group and model group comparing difference are statistically significant (P < 0.05)；It causes
2h and 3h after inflammation, granule low, middle and high dose groups and model group comparing difference it is statistically significant (P < 0.05 or P <
0.01), statistically significant (P < 0.01) with blank group comparing difference, i.e., normal mouse caused by granule Carrageenan is sufficient
Toe swelling has certain inhibiting effect, but effect is unobvious.(note: compared with blank group: P < 0.01 * P < 0.05, * *；With model
Group compares: ▲ P < 0.05, ▲ ▲ P < 0.01).
3.5, Fig. 6 is schematic diagram of the granule to uterus effect of contraction in an embodiment of the invention.
It will be appreciated from fig. 6 that granule each group can reduce the uterine motility enhanced by estrogen, high dose group, middle dose
Amount group, low dose group uterine motility and model group comparing difference are statistically significant (P < 0.05 or P < 0.01), wherein high
Dosage group and blank group comparing difference are not statistically significant, not statistically significant with bolus for woman diseases group comparing difference.(note: with blank
Group compares: P < 0.01 * P < 0.05, * *；Compared with model group: ▲ P < 0.05, ▲ ▲ P < 0.01；Compared with bolus for woman diseases group: ▼ P <
0.05, ▼ P < 0.01 ▼).
3.6, Fig. 7 to Fig. 8 is schematic diagram of the granule to serumβ-ep content in an embodiment of the invention.
As shown in Figure 8, each group can reduce the serumβ-ep content increased extremely by estrogen, high agent to a certain extent
Amount group, middle dose group serumβ-ep and model group comparing difference are statistically significant (P < 0.05 or P < 0.01), wherein high dose
Group is not statistically significant with blank group comparing difference, and each group and bolus for woman diseases group comparing difference are not statistically significant (with blank group ratio
Compared with: P < 0.01 * P < 0.05, * *；Compared with model group: ▲ P < 0.05, ▲ ▲ P < 0.01；Compared with bolus for woman diseases group: P < 0.05 ▼,
P < 0.01 ▼ ▼).
4, brief summary.
The present invention has investigated granule in embodiment 2 and has drawn to mouse corrosion disease analgesia, estrogen enhancing in the effect experiment stage
The uterine motility that rises, estrogen enhancing cause the influence of serumβ-ep level, the results showed that the present invention has centainly anti-inflammatory
Analgesic activity, tool are significantly reduced the uterine motility enhanced by estrogen, can reduce because of estrogen to a certain extent
Extremely serumβ-ep the content increased adjusts endocrine, alleviates menstrual pain.In short, by it is above-mentioned it is various experiment it can be proved that
Chinese medicine and health food of the invention has the healthcare function for alleviating menstrual pain, can enriching yin and nourishing kidney, QI invigorating analgesia, menstruction regulating and pain relieving.
Finally it should be noted that the above content is merely illustrative of the technical solution of the present invention, rather than the present invention is protected
The limitation of range, the simple modification or equivalent replacement that those skilled in the art carry out technical solution of the present invention,
All without departing from the spirit and scope of technical solution of the present invention.
Claims (9)
1. a kind of Chinese medicine and health food for alleviating menstrual period pain, it is characterised in that: the Chinese medicine health-care food for alleviating menstrual period pain
Product are mainly made of the raw material of following parts by weight: 1~10 part of raspberry, 1~8 part of nutmeg, 1~8 part of mulberries, peach kernel 1~8
Part, 1~6 part of rhizoma polygonati, 1~6 part of radix polygonati officinalis, 1~6 part of Gorgon fruit and 1~4 part of Radix Glycyrrhizae, the Chinese medicine health-care food for alleviating menstrual period pain
Product form Chinese materia medica preparation as active ingredient and appropriate additives by the water extract or alcohol extract of above-mentioned each raw material.
2. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 1, it is characterised in that: the alleviation warp
The Chinese medicine and health food of phase pain is mainly made of the raw material of following parts by weight: 4~8 parts of raspberry, 3~5 parts of nutmeg, mulberries
3~5 parts, 3~5 parts of peach kernel, 2~4 parts of rhizoma polygonati, 2~4 parts of radix polygonati officinalis, 2~4 parts of Gorgon fruit and 1~3 part of Radix Glycyrrhizae.
3. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 2, it is characterised in that: the alleviation warp
The Chinese medicine and health food of phase pain is mainly made of the raw material of following parts by weight: 6 parts of raspberry, 4 parts of nutmeg, 4 parts of mulberries, peach
4 parts of benevolence, 3 parts of rhizoma polygonati, 3 parts of radix polygonati officinalis, 3 parts of Gorgon fruit and 2 parts of Radix Glycyrrhizae.
4. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 1,2 or 3, it is characterised in that: described
The dosage form of Chinese materia medica preparation is granule or mixture.
5. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 4, it is characterised in that: the additives
For one of dietary supplement, preservative and filler or a variety of mixtures being mixed in any proportion.
6. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 5, it is characterised in that: the diet battalion
Support replenishers be one of minerals, vitamin, natto, plant protein powder or it is a variety of be mixed in any proportion it is mixed
Close object.
7. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 6, it is characterised in that: the minerals
For one of selenium, zinc, calcium, magnesium, potassium, iron, chromium, manganese or a variety of mixtures being mixed in any proportion；Vitamin is β-
One of carrotene, vitamin B1, vitamin B6, vitamin C, vitamin D, vitamin E are a variety of mixed with arbitrary proportion
Mixture made of conjunction；Plant protein powder is one of soybean protein isolate, lactalbumin, pea protein, collagen
Or a variety of mixtures being mixed in any proportion.
8. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 5, it is characterised in that: the filler
For ethyl alcohol, dextrin, starch, sucrose, glucose, honey, mannitol, xylitol, Steviosin, lactose, fructose, protein sugar, malt
One of sugar alcohol, Aspartame, flavoring banana essence, flavoring pineapple essence, vanillic aldehyde, fragrant citrus essence, Mint Essence and citric acid are more
The mixture that kind is mixed in any proportion.
9. a kind of Chinese medicine and health food for alleviating menstrual period pain according to claim 5, it is characterised in that: the preservative
For peppermint oil, cinnaldehydrum, eucalyptus oil, benzoic acid, sodium benzoate, methylparaben, ethylparaben, propylben, Ni Bo
One of golden butyl ester and sorbic acid or a variety of mixtures being mixed in any proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811422604.XA CN109463749A (en) | 2018-11-27 | 2018-11-27 | A kind of Chinese medicine and health food for alleviating menstrual period pain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811422604.XA CN109463749A (en) | 2018-11-27 | 2018-11-27 | A kind of Chinese medicine and health food for alleviating menstrual period pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109463749A true CN109463749A (en) | 2019-03-15 |
Family
ID=65673260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811422604.XA Pending CN109463749A (en) | 2018-11-27 | 2018-11-27 | A kind of Chinese medicine and health food for alleviating menstrual period pain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109463749A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757549A (en) * | 2008-11-19 | 2010-06-30 | 唐超 | Traditional Chinese medicine formula for treating dysmenorrhea |
| CN107349411A (en) * | 2017-08-11 | 2017-11-17 | 魏增强 | Chinese medicine composition for treating irregular menstruation and preparation method thereof |
| CN107912773A (en) * | 2017-11-13 | 2018-04-17 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation for being used to alleviate physical fatigue |
| CN108310347A (en) * | 2018-04-18 | 2018-07-24 | 丹阳市上古本真健康科技有限公司 | A kind of externally applied Chinese medicine and its application method |
-
2018
- 2018-11-27 CN CN201811422604.XA patent/CN109463749A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757549A (en) * | 2008-11-19 | 2010-06-30 | 唐超 | Traditional Chinese medicine formula for treating dysmenorrhea |
| CN107349411A (en) * | 2017-08-11 | 2017-11-17 | 魏增强 | Chinese medicine composition for treating irregular menstruation and preparation method thereof |
| CN107912773A (en) * | 2017-11-13 | 2018-04-17 | 广禾堂草本生物科技（上海）有限公司 | A kind of preparation for being used to alleviate physical fatigue |
| CN108310347A (en) * | 2018-04-18 | 2018-07-24 | 丹阳市上古本真健康科技有限公司 | A kind of externally applied Chinese medicine and its application method |
Non-Patent Citations (1)
| Title |
|---|
| 广禾堂月子调理食品: "月悦宝为生理期而来 广禾堂让您月来月美丽", 《HTTPS://M.SOHU.COM/A/125733565_382917》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104322617B (en) | Biscuit of a kind of auxiliary hyperglycemic and preparation method thereof | |
| CN105249326A (en) | Fermented fruit and vegetable composition containing probiotics and traditional Chinese medicine extract and preparation method of fermented fruit and vegetable composition | |
| CN101972338B (en) | Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof | |
| CN103690919B (en) | Medicine being used for the treatment of piglet iron-deficiency anemia and preparation method thereof | |
| CN105998297A (en) | Traditional Chinese medicine composition with effects of moistening intestines and relaxing bowels and preparation method thereof | |
| CN101579119A (en) | Nutritional food with function of relaxing bowel and preparation method thereof | |
| CN101884684A (en) | Food therapy preparation for preventing and treating constipation based on theories of preventive treatment of disease and medicine food homology | |
| CN102988675B (en) | Traditional Chinese medicine combination for treating chronic prostatitis and preparation method thereof | |
| CN107912773A (en) | A kind of preparation for being used to alleviate physical fatigue | |
| CN109125516A (en) | One group of Herb Tea and its preparation method and application | |
| CN117599140A (en) | Traditional Chinese medicine composition for reducing blood sugar, blood pressure and blood fat and preparation and application thereof | |
| CN105028995A (en) | Mixed dog food and preparation method thereof | |
| CN102008083B (en) | Health food for alleviating physical fatigue and removing chloasma | |
| CN103977390B (en) | A kind of preparation method and its usage of ginger onion medicated wine composition | |
| CN105194301A (en) | Traditional Chinese medicine preparation for treating chronic cardiac failure | |
| CN104286864A (en) | Flatstem milkvetch seed oral liquid for improving immunity and preparation method thereof | |
| CN109463749A (en) | A kind of Chinese medicine and health food for alleviating menstrual period pain | |
| CN103181557A (en) | Nutritious food with slimming function and preparation method thereof | |
| CN109452639A (en) | A kind of preparation method of Chinese medicine and health food that alleviating menstrual period pain | |
| CN101884698A (en) | Food therapy preparation for preventing and treating climacteric syndrome based on theories of preventive treatment of disease and medicine food homology | |
| CN100525804C (en) | Chinese traditional medicine compound preparations having a function of slimming | |
| CN110025011A (en) | A kind of Radix Ophiopogonis ginseng lozenge of strengthen immunity | |
| CN104800662A (en) | Traditional Chinese medicine for treating senile heart failure and preparation method thereof | |
| CN104352973A (en) | Chinese patent medicine for postpartum depression | |
| CN104258224A (en) | Schisandra chinensis oral solution for treating lung-and-kidney yin-deficiency type chronic bronchitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190315 |