CN109432322A - A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore - Google Patents
A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore Download PDFInfo
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- CN109432322A CN109432322A CN201811586142.5A CN201811586142A CN109432322A CN 109432322 A CN109432322 A CN 109432322A CN 201811586142 A CN201811586142 A CN 201811586142A CN 109432322 A CN109432322 A CN 109432322A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention belongs to the field of Chinese medicines; specifically disclose a kind of Chinese medicine composition and preparation method thereof for preventing and treating canker sore; the composition includes the raw material of following weight parts composition: 20-40 parts of borax; 10-40 parts of Cortex Phellodendri; 5-35 parts of indigo naturalis, 5-20 parts of catechu, 6-25 parts of lophatherum gracile, 5-20 parts of reed root, 5-20 parts of radix scrophulariae, 5-15 parts of cow-bezoar.In the present invention; the clearing heat and detoxicating anti-inflammatory of Cortex Phellodendri; the non-specific immunity that body can be improved simultaneously, is equipped with indigo naturalis, the clearing heat and cooling blood of radix scrophulariae, lophatherum gracile, reed root clearing heat-fire; the effect that is antipyretic, anti-inflammatory and promoting drug absorption because increasing surface of a wound capillary permeability of cow-bezoar; it is aided with the disinfection and astriction of catechu hygroscopic, myogenic, sore and borax, collective effect reduces oral cavity harmful bacteria and breeds; oral cavity internal heat is removed, makes that ability to speak is pure and fresh, oral cavity is healthier comfortable.
Description
Technical field
The present invention relates to a kind of Chinese medicines for having both prevention and treatment canker sore, belong to the field of Chinese medicines.
Background technique
Canker sore, also known as " aphtha ", are the superficial ulcers occurred on oral mucosa, and size can be from the grain of rice to Huang
Beans size, at round or oval, ulcer surface be it is recessed, around it is congested, can cause pain because of irritable food, it is general one or two
Week can be with self-healing.Canker sore has the characteristics that periodical, recurrent and self limiting, is apt to occur in lip, cheek, lingual margin etc..The cause of disease
And pathogenic mechanism is still indefinite, possible inducement is local trauma, stress, food, drug, hormonal readiness changes and vitamin
Or microelement deficiencies.
Canker sore is a kind of most common disease of cari oris mucosa, and illness rate is generally acknowledged that more than 10% in crowd, can
To betide men and women, old and young, with young and middle-aged most common.
Canker sore is a kind of oral mucosa limitation ulcer damage with the characteristics of cyclical recurrent, can be certainly
More, any position of oral mucosa can be betided, common with lip, cheek, tongue, serious person can involve pharyngeal mucosa.It is many to suffer from
Extension of the person with the course of disease, ulcer area increase, number increase, and pain aggravates, and healing stage extends, and interval shortening etc. influences
It diet and speaks.
Real example and two class of asthenic symptoms can be clinically divided into.Asthenic symptoms are often easy to recur, therefore also known as recurrent aphthous ulcer.
Treatment for canker sore, doctor trained in Western medicine common antibiotics carry out antiphlogistic antibacterial, common to have side effect, at present in Chinese medicine
There are some powders to be used to treat canker sore, the application method of powder is to spread on affected part posterior phraynx clothes, is contained in common powder formale
There is borax, but borax is very big to the harmfulness of human health, continuous intake can accumulate in vivo, harm the work of gastral enzyme
With the retention toxicosis of multi viscera can be caused, therefore it is food additive that countries in the world disable borax more if human body takes in excessive boron
Add object.It and is essentially all at present symptomatic treatment for the treatment of canker sore, purpose mainly mitigates pain or reduces multiple
Number is sent out, but recurrence cannot be fully controlled, so it is particularly important to prevent this disease.
Summary of the invention
The object of the invention is that providing a kind of Chinese traditional medicine composition for the treatment of canker sore for having both preventive and therapeutic action
Object, prepares easy to use, and good effect has no toxic side effect.
To achieve the goals above, the technical solution adopted by the present invention is that it is such:
A kind of Chinese medicine composition preventing and treating canker sore, the raw material including following weight parts composition: borax 20-40
Part, 10-40 parts of Cortex Phellodendri, 5-35 parts of indigo naturalis, 5-20 parts of catechu, 6-25 parts of lophatherum gracile, 5-20 parts of reed root, 5-20 parts of radix scrophulariae, cow-bezoar
5-15 parts.
Further technical solution is the raw material for including following weight parts composition: 22-38 parts of borax, 15-35 parts of Cortex Phellodendri, green
10-30 parts of black pigment used by women in ancient times to paint their eyebrows, 8-18 parts of catechu, 10-20 parts of lophatherum gracile, 6-15 parts of reed root, 8-18 parts of radix scrophulariae, 6-14 parts of cow-bezoar.
Further technical solution is the raw material for including following weight parts composition: 25-35 parts of borax, 20-30 parts of Cortex Phellodendri,
15-25 parts of indigo naturalis, 10-15 parts of catechu, 12-18 parts of lophatherum gracile, 8-12 parts of reed root, 10-15 parts of radix scrophulariae, 8-12 parts of cow-bezoar.
Optimal technical scheme is the raw material for including following weight parts composition: 30 parts of borax, 25 parts of Cortex Phellodendri, and 20 parts of indigo naturalis, youngster
12 parts of tea, 15 parts of lophatherum gracile, 9 parts of reed root, 12 parts of radix scrophulariae, 10 parts of cow-bezoar.
The present invention also provides the Chinese medicine compositions the preparation method comprises the following steps: (1) is formed according to required parts by weight simultaneously
Each raw material of precise；(2) raw material for having weighed weight is uniformly mixed in addition to borax, it is small to impregnate 0.5-1 with 5~20 times of amount water
When after be heated to boiling, keep slight boiling condition 0.5-1 hours, be cooled to 70-80 DEG C of filtering, load weighted boron be added into filtrate
Sand, stirring and dissolving filtering, obtains filtrate.
The filtrate of above-mentioned preparation can use directly as mouthwashes, and application method is to contain to gargle medical fluid a few minutes in mouth daily
It spues afterwards, avoids oral borax and accumulate the injury caused by human body in body, have no toxic side effect.
The drug effect of each raw material is as described below in above-mentioned formula:
1, borax: chemical name sodium tetraborate is semi-transparent clear crystal or white crystalline powder.It is odorless, nature and flavor are sweet,
Salty, cool, external application is clearing heat and detoxicating, detumescence, anti-corrosion.Medically, borax for the disinfection anti-corrosion of skin and mucosa, fluorosis of bone, tinea pedis,
Pulpitis, colpomycosis, cervical erosion, bedsore, acne, eczema of external auditory canal, dermopathic herpesvirus disease, epilepsy are controlled
It treats, is also used to the treatment of tumour in recent years.
2, Cortex Phellodendri: for the dry bark of rutaceae wampee or cork tree.Taste bitter and cold, there is heat-clearing and damp-drying drug, and purging intense heat removes
The effect of steaming, detoxification sore treatment.
Modern pharmacological studies have shown that: Cortex Phellodendri is in hypoglycemic effect, hypotensive activity, antibacterial, anti-inflammatory, refrigeration function, anticancer
It acts on, to immune system effect, anti-ulcer effect, antioxidation, antigout effect, prostate osmosis, antiviral work
There is good effect with equal various aspects.
3, indigo naturalis: for acanthaceous vegetable acanthaceous indigo Baphicacanthus cusia (Nees) Bremek., polygonaceae plant indigo plant
The leaf or cauline leaf of Polygonum tinctorium Ait. or cruciferae isatis Isatis indigotica Fort.
Processed dried powder obtained or agglomerate.With the effect of clearing heat and detoxicating, blood cooling and ecchymoses removing, purging intense heat is calmed the frightened.For febrile virulent maculae,
Blood-head tells nosebleed, pectoralgia hemoptysis, aphtha mumps, sore throat, pediatric epilepsy scared.
4, catechu: for the peeling branch, dry of pulse family albizzia plant catechu tree Acacia catechu (L.f.) Willd.
Dry soft extracts.Bitter, puckery, cold nature.It is distributed in lung channel.There is the effect of hygroscopic myogenic sore.For unhealing ulcer, eczema, aphtha,
The pain of injury caused by falling and tumbling, traumatic hemorrhage.
5, lophatherum gracile: for the drying cauline leaf of grass henon bamboo leaf LophatherumgracileBrongn..Sweet in flavor,
It is light, it is cold in nature.Return heart, stomach, small intestinl channel.With clearing heat-fire, the effect of relieving restlessness is quenched the thirst, inducing diuresis for treating strangurtia.For pyreticosis and polydipsia, urine
Short red puckery pain, aphthae.
6, reed root: for the fresh or dry rhizome of gramineae plant reed PhragmitescommunisTrin..It is sweet in flavor,
It is cold in nature.It attaches to the lung and stomach meridians.It with clearing heat-fire, promotes the production of body fluid to quench thirst, the effect of relieving restlessness, preventing or arresting vomiting, diuresis.For pyreticosis and polydipsia, lung heat cough
It coughs, lung carbuncle pyemesis, stomach hot vomiting, puckery pain of heat gonorrhea.
7, radix scrophulariae: for the dry root of scrophulariaceae radix scrophulariae scrophularianingpoensisHemsl..Sweet in flavor, bitter,
It is salty, cold nature.Return lung, stomach, kidney channel.With clearing heat and cooling blood, the effect of nourishing yin and lessening fire, detoxicating and resolving a mass.Enter ying blood, epidemic heat syndrome for heat
Macular eruption, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
8, western yellow, rhinoceros Huang, ugly treasured cow-bezoar: are called.The cholecystolithiasis (minority is calculus of bile duct) of ox, is natural ox gallstone.By
Fel bovis extracts the title calculus bovis factitius being process.Grind take after mixing it with water or enter ball dissipate.
This product bitter is cool in nature, gas fragrance, has good effects for removing toxic heat, and energy cool liver dispelling wind and relieving convulsion, clearing away heart-fire and eliminating phlegm are opened
Key festers for abscess of throat, the card of the heat toxins pent-up such as aphthae, ulcer serious case of furuncle, and oral administration and externally has good effect, and kind controls heat
Sick coma and delirium, the cards such as stroke and phlegm confusing heart is fainted, epilepsy is gone mad, convulsion.
Modern pharmacological studies have shown that cow-bezoar also has antipyretic and anti-inflammatory effect, mouse peritoneal hair caused by cow-bezoar Dichlorodiphenyl Acetate
Thin vasopermeability increases, polymorphonuclear cell migration and rat formaldehyde filter paper granulation tissue hyperplasia have strong inhibition to make
With the increased inhibitory activity of mouse peritoneal permeability caused by Dichlorodiphenyl Acetate is 33 times of of salicylic 47 times, hydrocortisone
Its anti-inflammatory effect can have the anti-inflammatory effect of significant change cultivating artificial calculus bovis similar to cow-bezoar because of its compatibility difference, 1~2g/
Kg can significantly inhibit mouse claw caused by mouse ear caused by croton oil, dimethylbenzene etc. is swollen and carrageenan to mouse gavaging
Oedema；0.1g/kg is injected intraperitoneally, and mouse ear caused by paraxylene swells, mouse skin caused by dimethylbenzene intracutaneous injection is penetrating
Property increase, mouse granulation tissue hyperplasia has inhibiting effect caused by rat egg white foot is swollen and formaldehyde foot is swollen and cotton balls.
In the present invention, Cortex Phellodendri taste bitter and cold is longer than heat-clearing and damp-drying drug, purging fire for removing toxin, is good clearing heat and detoxicating anti-inflammatory drug, tool
There is broad-spectrum antibacterial action, other than stronger antibacterial action, can also diminish inflammation rapidly oedema, improve microcirculation, promote wound
Face necrotic tissue falls off, accelerates epithelial tissue newborn, thus the effect of generating the repairing ulcer surface of a wound, moreover it is possible to it is thin to enhance monokaryon macrophage
The phagocytic activity of born of the same parents improves the non-specific immunity of body.It is equipped with indigo naturalis, the clearing heat and cooling blood of radix scrophulariae, lophatherum gracile, reed root heat-clearing
Purging intense heat, the effect that is antipyretic, anti-inflammatory and promoting drug absorption because increasing surface of a wound capillary permeability of cow-bezoar, is aided with catechu receipts
The disinfection and astriction of wet, myogenic, sore and boric acid, collective effect reduce oral cavity harmful bacteria and breed, and remove oral cavity fire
Gas, makes that ability to speak is pure and fresh, oral cavity is healthier comfortable.It is used when no ulcer, can reach the effect of pre- ulcer；Make when ulcer has occurred
With can reach the effect quickly treated.
Therefore multiple medicine of the present invention shares, and respectively plays a role and mutually promotes, has both prevention and treatment efficacy, collective effect
In the canker sore surface of a wound, detoxify antibacterial, swelling and pain relieving are removed the rotten and let fresh grow；Finished product is mouthwashes, and use is easy to carry, good effect, nothing
Toxic side effect.
Specific embodiment
In order to which the purpose of the present invention, technical solution and beneficial effect is more clearly understood, the present invention is done into one below
The explanation of step, but protection scope of the present invention is not limited in the examples below.
One, the present composition is prepared
(1) formula table (unit: weight)
(2) preparation method: each raw material of precise is formed according to weight, the raw material for having weighed weight is mixed in addition to borax
It is heated to boiling after uniformly being impregnated 0.5-1 hours with 10 times of amount water, is kept for slight boiling condition 0.5-1 hours, be cooled to 70-80 DEG C of mistake
It filters, load weighted borax is added in filtrate, stirring and dissolving filters to get filtrate.
The filtrate uses directly as mouthwashes.
Two, clinical trial results
(1) basic data: 174 patients, wherein male 74, women 100, the age 18~72 years old, average age 36
Year, medical history 1 year or more.Annual breaking-out 4 times or more, ulcer number is single or multiple to be differed, and average course of disease 1 week.Clinical manifestation with
Mucous membrane of mouth part is red and swollen and center ulcer, erosion, based on pain.Exclude traumatic ulcer and serious systemic disease, no medicine
Object allergies.
(2) experimental method: above-mentioned patient is divided into administration group and two groups of control group, every group 87, nothing is significant between group
Sex differernce.
Administration group: the mouthwashes prepared using 1-7 of the embodiment of the present invention, daily containing gargling medical fluid 3 times, each 15ml, about
It spues after 3min.
Control group: oral vitamin B2 piece, one time 2,3 times a day；And buccal Dobell, 2 tablets once, 3 times a day, 14
It is 1 course for the treatment of.
Two groups of patients do not take other drugs during treatment, and appropriate level of work and rest, feelings will is happy, fasting raw food, pungent oil
Greasy object.Curative effect is evaluated after the course for the treatment of.
(3) curative effect determinate standard:
It is effective --- the red and swollen decline in part, without pain symptom, ulcer healing after medication 3d are had meal normal.
Improving --- ulcer surface is obviously reduced after medication 1 week, without pain symptom.
In vain --- subjective symptoms and sign are without any improvement.
Effective and improvement is determined as effectively.
(4) clinical trial results:
Administration group: responding time is most 1 day short, and longest 3 days；It treats canker sore result are as follows:
In 3 days therapeutic process, the different patient of 87 illnesss is treated using the present composition, as a result effective 69
Example improves 12, and invalid 6, obvious effective rate 79.3%, improvement rate 13.8%, total effective rate 93.1%.In use, institute
There is patient not occur the adverse reactions such as allergy or malicious pair.
Control group: it the course for the treatment of 14 days, as a result see the table below.
Recurrence:
(5) conclusion:
Administration group obvious effective rate is higher than control group, and recurrence number is few, illustrates that prevention and treatment oral cavity prepared by the present invention is burst
The Chinese medicine composition effect of ulcer is fine.
Recurrent oral ulceration is a kind of clinical common mouth disease, is apt to occur in any age, men and women, old and young can send out
Raw, characteristics of incidence is that mucous membrane of mouth part is red and swollen and center ulcer, based on erosion and pain, and recurrent exerbation, it is normal to influence patient
Diet, and the cause of disease and pathogenesis are unknown so far, but many results of study show recurrent oral ulceration morbidity be it is a variety of because
The coefficient result of element.Currently, body's immunity is considered as one of its important pathogenic factors extremely.Due to recurrent mouth
Chamber canker because uncertainty, up to the present, there are no be directed to recurrent oral ulceration specific treatment method, current office
Portion's medication is to treat the important method of canker sore.
In the present invention:
Reticuloendothelial system phagocytic endotoxin in the effects of Cortex Phellodendri has to antiendotoxin, antibacterial, antiviral and reinforcement
With the effect of internal non-specific immune function (main active is phellodendrine and magnoflorine).Cortex Phellodendri is in antibacterial and detoxicating
Angiogenesis can be effectively facilitated in the process, and diminish inflammation oedema, improves microcirculation, and wound healing and granulation tissue is promoted to generate；
Cow-bezoar is clearing heat and detoxicating key medicine, is usually used in abscess of throat caused by heat toxin, sore, carbuncle and painful swelling and some surgical diseases, often
Indigo naturalis etc. is cooperated to use；Effective component is indigo in indigo naturalis and indigo red, there is clearing heat and detoxicating, cooling blood and hemostasis and other effects；Lophatherum gracile, reed
Root clearing heat-fire；Radix scrophulariae clearing heat and cooling blood, detoxicating and resolving a mass；Catechu hygroscopic, myogenic, sore；Boric acid disinfection, sterilization, convergence.Multiple medicine closes
With, respectively play a role and mutually promote, have both prevention and treatment efficacy, collective effect in the canker sore surface of a wound, antibacterial of detoxifying,
Swelling and pain relieving is removed the rotten and let fresh grow.
Claims (5)
1. a kind of Chinese medicine composition for preventing and treating canker sore, it is characterised in that: the raw material including following weight parts composition:
20-40 parts of borax, 10-40 parts of Cortex Phellodendri, 5-35 parts of indigo naturalis, 5-20 parts of catechu, 6-25 parts of lophatherum gracile, 5-20 parts of reed root, radix scrophulariae 5-
20 parts, 5-15 parts of cow-bezoar.
2. a kind of Chinese medicine composition for preventing and treating canker sore according to claim 1, it is characterised in that: including under
State parts by weight composition raw material: 22-38 parts of borax, 15-35 parts of Cortex Phellodendri, 10-30 parts of indigo naturalis, 8-18 parts of catechu, lophatherum gracile 10-20
Part, 6-15 parts of reed root, 8-18 parts of radix scrophulariae, 6-14 parts of cow-bezoar.
3. a kind of Chinese medicine composition for preventing and treating canker sore according to claim 2, it is characterised in that: including under
State parts by weight composition raw material: 25-35 parts of borax, 20-30 parts of Cortex Phellodendri, 15-25 parts of indigo naturalis, 10-15 parts of catechu, lophatherum gracile 12-
18 parts, 8-12 parts of reed root, 10-15 parts of radix scrophulariae, 8-12 parts of cow-bezoar.
4. a kind of Chinese medicine composition for preventing and treating canker sore according to claim 3, it is characterised in that: including under
State the raw material of parts by weight composition: 30 parts of borax, 25 parts of Cortex Phellodendri, 20 parts of indigo naturalis, 12 parts of catechu, 15 parts of lophatherum gracile, 9 parts of reed root, profound
12 parts, 10 parts of cow-bezoar of ginseng.
5. a kind of preparation method for preparing claim 1 to the Chinese medicine composition described in any one of claim 4, feature exist
In: including following preparation step:
(1) each raw material of precise is formed according to parts by weight described in claim；
(2) raw material for having weighed weight is uniformly mixed in addition to borax, is heated to after being impregnated 0.5-1 hours with 5~20 times of amount water
Boiling is kept for slight boiling condition 0.5-1 hours, is cooled to 70-80 DEG C of filtering, and load weighted borax is added into filtrate, is stirred molten
Solution filtering, obtains filtrate.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077512A (en) * | 1993-10-13 | 2000-06-20 | Chen; Ren-Rong | Externally-applied medicine for curing black foot disease |
| CN1279975A (en) * | 2000-07-11 | 2001-01-17 | 刘文功 | Medicine for curing stomatocase |
| CN107929424A (en) * | 2017-10-30 | 2018-04-20 | 四川金堂海纳生物医药技术研究所 | A kind of powder agent medicine and preparation method for being used to treat recurrent oral ulceration |
-
2018
- 2018-12-24 CN CN201811586142.5A patent/CN109432322A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077512A (en) * | 1993-10-13 | 2000-06-20 | Chen; Ren-Rong | Externally-applied medicine for curing black foot disease |
| CN1279975A (en) * | 2000-07-11 | 2001-01-17 | 刘文功 | Medicine for curing stomatocase |
| CN107929424A (en) * | 2017-10-30 | 2018-04-20 | 四川金堂海纳生物医药技术研究所 | A kind of powder agent medicine and preparation method for being used to treat recurrent oral ulceration |
Non-Patent Citations (1)
| Title |
|---|
| 张霞等: "消溃散治疗复发性口腔溃疡", 《中医药研究》 * |
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