CN109432322A - A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore - Google Patents
A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore Download PDFInfo
- Publication number
- CN109432322A CN109432322A CN201811586142.5A CN201811586142A CN109432322A CN 109432322 A CN109432322 A CN 109432322A CN 201811586142 A CN201811586142 A CN 201811586142A CN 109432322 A CN109432322 A CN 109432322A
- Authority
- CN
- China
- Prior art keywords
- parts
- borax
- chinese medicine
- raw material
- bezoar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000000203 mixture Substances 0.000 title claims abstract description 24
- 208000020670 canker sore Diseases 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 229910021538 borax Inorganic materials 0.000 claims abstract description 22
- 239000004328 sodium tetraborate Substances 0.000 claims abstract description 22
- 235000010339 sodium tetraborate Nutrition 0.000 claims abstract description 22
- 206010004542 Bezoar Diseases 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 240000003915 Lophatherum gracile Species 0.000 claims abstract description 14
- 235000014676 Phragmites communis Nutrition 0.000 claims abstract description 14
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 13
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 13
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims abstract description 13
- 244000080767 Areca catechu Species 0.000 claims abstract 6
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 244000131316 Panax pseudoginseng Species 0.000 claims 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 1
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 1
- 235000008434 ginseng Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 32
- 210000000214 mouth Anatomy 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 9
- 208000027418 Wounds and injury Diseases 0.000 abstract description 8
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 7
- 238000001816 cooling Methods 0.000 abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 5
- 230000001114 myogenic effect Effects 0.000 abstract description 4
- 230000001754 anti-pyretic effect Effects 0.000 abstract description 3
- 239000002221 antipyretic Substances 0.000 abstract description 3
- 229940126678 chinese medicines Drugs 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 3
- 230000001965 increasing effect Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000004856 capillary permeability Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 208000025865 Ulcer Diseases 0.000 description 16
- 231100000397 ulcer Toxicity 0.000 description 16
- 230000036407 pain Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 244000235603 Acacia catechu Species 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 230000000306 recurrent effect Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 208000002399 aphthous stomatitis Diseases 0.000 description 6
- 206010052428 Wound Diseases 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 238000010926 purge Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010063560 Excessive granulation tissue Diseases 0.000 description 3
- 206010028034 Mouth ulceration Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 206010015037 epilepsy Diseases 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000001126 granulation tissue Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 206010036067 polydipsia Diseases 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- -1 Dichlorodiphenyl Acetate Chemical compound 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 241001062009 Indigofera Species 0.000 description 2
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 240000001307 Myosotis scorpioides Species 0.000 description 2
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 206010000269 abscess Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 229940097275 indigo Drugs 0.000 description 2
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 230000000242 pagocytic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- YLRXAIKMLINXQY-ZDUSSCGKSA-O (S)-magnoflorine Chemical compound C1=C(OC)C(O)=C2C3=C(O)C(OC)=CC=C3C[C@@H]3[N+](C)(C)CCC1=C23 YLRXAIKMLINXQY-ZDUSSCGKSA-O 0.000 description 1
- MCSXGCZMEPXKIW-UHFFFAOYSA-N 3-hydroxy-4-[(4-methyl-2-nitrophenyl)diazenyl]-N-(3-nitrophenyl)naphthalene-2-carboxamide Chemical compound Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C(=O)Nc2cccc(c2)[N+]([O-])=O)c(c1)[N+]([O-])=O MCSXGCZMEPXKIW-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 235000006020 Acacia catechu Nutrition 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000220433 Albizia Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 208000004845 Cholecystolithiasis Diseases 0.000 description 1
- 244000089795 Clausena lansium Species 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- CRDNMYFJWFXOCH-BUHFOSPRSA-N Couroupitine B Natural products N\1C2=CC=CC=C2C(=O)C/1=C1/C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-BUHFOSPRSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010016818 Fluorosis Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 241000334154 Isatis tinctoria Species 0.000 description 1
- KYEAXNAYHSCLMT-CVVGWEDFSA-N Magnoflorine Natural products C[C@H]1OC=C2[C@@H]3[C@@H]1CN4CCc5c([nH]c6ccccc56)[C@@H]4[C@@H]3OC2=O KYEAXNAYHSCLMT-CVVGWEDFSA-N 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000382362 Persicaria tinctoria Species 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- RBBVPNQTBKHOEQ-KKSFZXQISA-O Phellodendrine Chemical group C1CC2=CC(OC)=C(O)C=C2[C@H]2[N@+]1(C)CC(C=C(C(=C1)O)OC)=C1C2 RBBVPNQTBKHOEQ-KKSFZXQISA-O 0.000 description 1
- 240000002014 Phyllostachys nigra var. henonis Species 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 241000219050 Polygonaceae Species 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000282806 Rhinoceros Species 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241001121987 Scrophularia ningpoensis Species 0.000 description 1
- 241000207844 Scrophulariaceae Species 0.000 description 1
- 241000257673 Strobilanthes cusia Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 244000299492 Thespesia populnea Species 0.000 description 1
- 235000009430 Thespesia populnea Nutrition 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 206010044546 Traumatic ulcer Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001986 anti-endotoxic effect Effects 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229960002708 antigout preparations Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
- 229940117173 croton oil Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000004042 dental fluorosis Diseases 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 210000000613 ear canal Anatomy 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000001130 gallstones Diseases 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- CRDNMYFJWFXOCH-UHFFFAOYSA-N indirubin Chemical compound N1C2=CC=CC=C2C(=O)C1=C1C2=CC=CC=C2NC1=O CRDNMYFJWFXOCH-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229940037201 oris Drugs 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008359 toxicosis Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of Chinese medicines; specifically disclose a kind of Chinese medicine composition and preparation method thereof for preventing and treating canker sore; the composition includes the raw material of following weight parts composition: 20-40 parts of borax; 10-40 parts of Cortex Phellodendri; 5-35 parts of indigo naturalis, 5-20 parts of catechu, 6-25 parts of lophatherum gracile, 5-20 parts of reed root, 5-20 parts of radix scrophulariae, 5-15 parts of cow-bezoar.In the present invention; the clearing heat and detoxicating anti-inflammatory of Cortex Phellodendri; the non-specific immunity that body can be improved simultaneously, is equipped with indigo naturalis, the clearing heat and cooling blood of radix scrophulariae, lophatherum gracile, reed root clearing heat-fire; the effect that is antipyretic, anti-inflammatory and promoting drug absorption because increasing surface of a wound capillary permeability of cow-bezoar; it is aided with the disinfection and astriction of catechu hygroscopic, myogenic, sore and borax, collective effect reduces oral cavity harmful bacteria and breeds; oral cavity internal heat is removed, makes that ability to speak is pure and fresh, oral cavity is healthier comfortable.
Description
Technical field
The present invention relates to a kind of Chinese medicines for having both prevention and treatment canker sore, belong to the field of Chinese medicines.
Background technique
Canker sore, also known as " aphtha ", are the superficial ulcers occurred on oral mucosa, and size can be from the grain of rice to Huang
Beans size, at round or oval, ulcer surface be it is recessed, around it is congested, can cause pain because of irritable food, it is general one or two
Week can be with self-healing.Canker sore has the characteristics that periodical, recurrent and self limiting, is apt to occur in lip, cheek, lingual margin etc..The cause of disease
And pathogenic mechanism is still indefinite, possible inducement is local trauma, stress, food, drug, hormonal readiness changes and vitamin
Or microelement deficiencies.
Canker sore is a kind of most common disease of cari oris mucosa, and illness rate is generally acknowledged that more than 10% in crowd, can
To betide men and women, old and young, with young and middle-aged most common.
Canker sore is a kind of oral mucosa limitation ulcer damage with the characteristics of cyclical recurrent, can be certainly
More, any position of oral mucosa can be betided, common with lip, cheek, tongue, serious person can involve pharyngeal mucosa.It is many to suffer from
Extension of the person with the course of disease, ulcer area increase, number increase, and pain aggravates, and healing stage extends, and interval shortening etc. influences
It diet and speaks.
Real example and two class of asthenic symptoms can be clinically divided into.Asthenic symptoms are often easy to recur, therefore also known as recurrent aphthous ulcer.
Treatment for canker sore, doctor trained in Western medicine common antibiotics carry out antiphlogistic antibacterial, common to have side effect, at present in Chinese medicine
There are some powders to be used to treat canker sore, the application method of powder is to spread on affected part posterior phraynx clothes, is contained in common powder formale
There is borax, but borax is very big to the harmfulness of human health, continuous intake can accumulate in vivo, harm the work of gastral enzyme
With the retention toxicosis of multi viscera can be caused, therefore it is food additive that countries in the world disable borax more if human body takes in excessive boron
Add object.It and is essentially all at present symptomatic treatment for the treatment of canker sore, purpose mainly mitigates pain or reduces multiple
Number is sent out, but recurrence cannot be fully controlled, so it is particularly important to prevent this disease.
Summary of the invention
The object of the invention is that providing a kind of Chinese traditional medicine composition for the treatment of canker sore for having both preventive and therapeutic action
Object, prepares easy to use, and good effect has no toxic side effect.
To achieve the goals above, the technical solution adopted by the present invention is that it is such:
A kind of Chinese medicine composition preventing and treating canker sore, the raw material including following weight parts composition: borax 20-40
Part, 10-40 parts of Cortex Phellodendri, 5-35 parts of indigo naturalis, 5-20 parts of catechu, 6-25 parts of lophatherum gracile, 5-20 parts of reed root, 5-20 parts of radix scrophulariae, cow-bezoar
5-15 parts.
Further technical solution is the raw material for including following weight parts composition: 22-38 parts of borax, 15-35 parts of Cortex Phellodendri, green
10-30 parts of black pigment used by women in ancient times to paint their eyebrows, 8-18 parts of catechu, 10-20 parts of lophatherum gracile, 6-15 parts of reed root, 8-18 parts of radix scrophulariae, 6-14 parts of cow-bezoar.
Further technical solution is the raw material for including following weight parts composition: 25-35 parts of borax, 20-30 parts of Cortex Phellodendri,
15-25 parts of indigo naturalis, 10-15 parts of catechu, 12-18 parts of lophatherum gracile, 8-12 parts of reed root, 10-15 parts of radix scrophulariae, 8-12 parts of cow-bezoar.
Optimal technical scheme is the raw material for including following weight parts composition: 30 parts of borax, 25 parts of Cortex Phellodendri, and 20 parts of indigo naturalis, youngster
12 parts of tea, 15 parts of lophatherum gracile, 9 parts of reed root, 12 parts of radix scrophulariae, 10 parts of cow-bezoar.
The present invention also provides the Chinese medicine compositions the preparation method comprises the following steps: (1) is formed according to required parts by weight simultaneously
Each raw material of precise;(2) raw material for having weighed weight is uniformly mixed in addition to borax, it is small to impregnate 0.5-1 with 5~20 times of amount water
When after be heated to boiling, keep slight boiling condition 0.5-1 hours, be cooled to 70-80 DEG C of filtering, load weighted boron be added into filtrate
Sand, stirring and dissolving filtering, obtains filtrate.
The filtrate of above-mentioned preparation can use directly as mouthwashes, and application method is to contain to gargle medical fluid a few minutes in mouth daily
It spues afterwards, avoids oral borax and accumulate the injury caused by human body in body, have no toxic side effect.
The drug effect of each raw material is as described below in above-mentioned formula:
1, borax: chemical name sodium tetraborate is semi-transparent clear crystal or white crystalline powder.It is odorless, nature and flavor are sweet,
Salty, cool, external application is clearing heat and detoxicating, detumescence, anti-corrosion.Medically, borax for the disinfection anti-corrosion of skin and mucosa, fluorosis of bone, tinea pedis,
Pulpitis, colpomycosis, cervical erosion, bedsore, acne, eczema of external auditory canal, dermopathic herpesvirus disease, epilepsy are controlled
It treats, is also used to the treatment of tumour in recent years.
2, Cortex Phellodendri: for the dry bark of rutaceae wampee or cork tree.Taste bitter and cold, there is heat-clearing and damp-drying drug, and purging intense heat removes
The effect of steaming, detoxification sore treatment.
Modern pharmacological studies have shown that: Cortex Phellodendri is in hypoglycemic effect, hypotensive activity, antibacterial, anti-inflammatory, refrigeration function, anticancer
It acts on, to immune system effect, anti-ulcer effect, antioxidation, antigout effect, prostate osmosis, antiviral work
There is good effect with equal various aspects.
3, indigo naturalis: for acanthaceous vegetable acanthaceous indigo Baphicacanthus cusia (Nees) Bremek., polygonaceae plant indigo plant
The leaf or cauline leaf of Polygonum tinctorium Ait. or cruciferae isatis Isatis indigotica Fort.
Processed dried powder obtained or agglomerate.With the effect of clearing heat and detoxicating, blood cooling and ecchymoses removing, purging intense heat is calmed the frightened.For febrile virulent maculae,
Blood-head tells nosebleed, pectoralgia hemoptysis, aphtha mumps, sore throat, pediatric epilepsy scared.
4, catechu: for the peeling branch, dry of pulse family albizzia plant catechu tree Acacia catechu (L.f.) Willd.
Dry soft extracts.Bitter, puckery, cold nature.It is distributed in lung channel.There is the effect of hygroscopic myogenic sore.For unhealing ulcer, eczema, aphtha,
The pain of injury caused by falling and tumbling, traumatic hemorrhage.
5, lophatherum gracile: for the drying cauline leaf of grass henon bamboo leaf LophatherumgracileBrongn..Sweet in flavor,
It is light, it is cold in nature.Return heart, stomach, small intestinl channel.With clearing heat-fire, the effect of relieving restlessness is quenched the thirst, inducing diuresis for treating strangurtia.For pyreticosis and polydipsia, urine
Short red puckery pain, aphthae.
6, reed root: for the fresh or dry rhizome of gramineae plant reed PhragmitescommunisTrin..It is sweet in flavor,
It is cold in nature.It attaches to the lung and stomach meridians.It with clearing heat-fire, promotes the production of body fluid to quench thirst, the effect of relieving restlessness, preventing or arresting vomiting, diuresis.For pyreticosis and polydipsia, lung heat cough
It coughs, lung carbuncle pyemesis, stomach hot vomiting, puckery pain of heat gonorrhea.
7, radix scrophulariae: for the dry root of scrophulariaceae radix scrophulariae scrophularianingpoensisHemsl..Sweet in flavor, bitter,
It is salty, cold nature.Return lung, stomach, kidney channel.With clearing heat and cooling blood, the effect of nourishing yin and lessening fire, detoxicating and resolving a mass.Enter ying blood, epidemic heat syndrome for heat
Macular eruption, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.
8, western yellow, rhinoceros Huang, ugly treasured cow-bezoar: are called.The cholecystolithiasis (minority is calculus of bile duct) of ox, is natural ox gallstone.By
Fel bovis extracts the title calculus bovis factitius being process.Grind take after mixing it with water or enter ball dissipate.
This product bitter is cool in nature, gas fragrance, has good effects for removing toxic heat, and energy cool liver dispelling wind and relieving convulsion, clearing away heart-fire and eliminating phlegm are opened
Key festers for abscess of throat, the card of the heat toxins pent-up such as aphthae, ulcer serious case of furuncle, and oral administration and externally has good effect, and kind controls heat
Sick coma and delirium, the cards such as stroke and phlegm confusing heart is fainted, epilepsy is gone mad, convulsion.
Modern pharmacological studies have shown that cow-bezoar also has antipyretic and anti-inflammatory effect, mouse peritoneal hair caused by cow-bezoar Dichlorodiphenyl Acetate
Thin vasopermeability increases, polymorphonuclear cell migration and rat formaldehyde filter paper granulation tissue hyperplasia have strong inhibition to make
With the increased inhibitory activity of mouse peritoneal permeability caused by Dichlorodiphenyl Acetate is 33 times of of salicylic 47 times, hydrocortisone
Its anti-inflammatory effect can have the anti-inflammatory effect of significant change cultivating artificial calculus bovis similar to cow-bezoar because of its compatibility difference, 1~2g/
Kg can significantly inhibit mouse claw caused by mouse ear caused by croton oil, dimethylbenzene etc. is swollen and carrageenan to mouse gavaging
Oedema;0.1g/kg is injected intraperitoneally, and mouse ear caused by paraxylene swells, mouse skin caused by dimethylbenzene intracutaneous injection is penetrating
Property increase, mouse granulation tissue hyperplasia has inhibiting effect caused by rat egg white foot is swollen and formaldehyde foot is swollen and cotton balls.
In the present invention, Cortex Phellodendri taste bitter and cold is longer than heat-clearing and damp-drying drug, purging fire for removing toxin, is good clearing heat and detoxicating anti-inflammatory drug, tool
There is broad-spectrum antibacterial action, other than stronger antibacterial action, can also diminish inflammation rapidly oedema, improve microcirculation, promote wound
Face necrotic tissue falls off, accelerates epithelial tissue newborn, thus the effect of generating the repairing ulcer surface of a wound, moreover it is possible to it is thin to enhance monokaryon macrophage
The phagocytic activity of born of the same parents improves the non-specific immunity of body.It is equipped with indigo naturalis, the clearing heat and cooling blood of radix scrophulariae, lophatherum gracile, reed root heat-clearing
Purging intense heat, the effect that is antipyretic, anti-inflammatory and promoting drug absorption because increasing surface of a wound capillary permeability of cow-bezoar, is aided with catechu receipts
The disinfection and astriction of wet, myogenic, sore and boric acid, collective effect reduce oral cavity harmful bacteria and breed, and remove oral cavity fire
Gas, makes that ability to speak is pure and fresh, oral cavity is healthier comfortable.It is used when no ulcer, can reach the effect of pre- ulcer;Make when ulcer has occurred
With can reach the effect quickly treated.
Therefore multiple medicine of the present invention shares, and respectively plays a role and mutually promotes, has both prevention and treatment efficacy, collective effect
In the canker sore surface of a wound, detoxify antibacterial, swelling and pain relieving are removed the rotten and let fresh grow;Finished product is mouthwashes, and use is easy to carry, good effect, nothing
Toxic side effect.
Specific embodiment
In order to which the purpose of the present invention, technical solution and beneficial effect is more clearly understood, the present invention is done into one below
The explanation of step, but protection scope of the present invention is not limited in the examples below.
One, the present composition is prepared
(1) formula table (unit: weight)
(2) preparation method: each raw material of precise is formed according to weight, the raw material for having weighed weight is mixed in addition to borax
It is heated to boiling after uniformly being impregnated 0.5-1 hours with 10 times of amount water, is kept for slight boiling condition 0.5-1 hours, be cooled to 70-80 DEG C of mistake
It filters, load weighted borax is added in filtrate, stirring and dissolving filters to get filtrate.
The filtrate uses directly as mouthwashes.
Two, clinical trial results
(1) basic data: 174 patients, wherein male 74, women 100, the age 18~72 years old, average age 36
Year, medical history 1 year or more.Annual breaking-out 4 times or more, ulcer number is single or multiple to be differed, and average course of disease 1 week.Clinical manifestation with
Mucous membrane of mouth part is red and swollen and center ulcer, erosion, based on pain.Exclude traumatic ulcer and serious systemic disease, no medicine
Object allergies.
(2) experimental method: above-mentioned patient is divided into administration group and two groups of control group, every group 87, nothing is significant between group
Sex differernce.
Administration group: the mouthwashes prepared using 1-7 of the embodiment of the present invention, daily containing gargling medical fluid 3 times, each 15ml, about
It spues after 3min.
Control group: oral vitamin B2 piece, one time 2,3 times a day;And buccal Dobell, 2 tablets once, 3 times a day, 14
It is 1 course for the treatment of.
Two groups of patients do not take other drugs during treatment, and appropriate level of work and rest, feelings will is happy, fasting raw food, pungent oil
Greasy object.Curative effect is evaluated after the course for the treatment of.
(3) curative effect determinate standard:
It is effective --- the red and swollen decline in part, without pain symptom, ulcer healing after medication 3d are had meal normal.
Improving --- ulcer surface is obviously reduced after medication 1 week, without pain symptom.
In vain --- subjective symptoms and sign are without any improvement.
Effective and improvement is determined as effectively.
(4) clinical trial results:
Administration group: responding time is most 1 day short, and longest 3 days;It treats canker sore result are as follows:
In 3 days therapeutic process, the different patient of 87 illnesss is treated using the present composition, as a result effective 69
Example improves 12, and invalid 6, obvious effective rate 79.3%, improvement rate 13.8%, total effective rate 93.1%.In use, institute
There is patient not occur the adverse reactions such as allergy or malicious pair.
Control group: it the course for the treatment of 14 days, as a result see the table below.
Recurrence:
(5) conclusion:
Administration group obvious effective rate is higher than control group, and recurrence number is few, illustrates that prevention and treatment oral cavity prepared by the present invention is burst
The Chinese medicine composition effect of ulcer is fine.
Recurrent oral ulceration is a kind of clinical common mouth disease, is apt to occur in any age, men and women, old and young can send out
Raw, characteristics of incidence is that mucous membrane of mouth part is red and swollen and center ulcer, based on erosion and pain, and recurrent exerbation, it is normal to influence patient
Diet, and the cause of disease and pathogenesis are unknown so far, but many results of study show recurrent oral ulceration morbidity be it is a variety of because
The coefficient result of element.Currently, body's immunity is considered as one of its important pathogenic factors extremely.Due to recurrent mouth
Chamber canker because uncertainty, up to the present, there are no be directed to recurrent oral ulceration specific treatment method, current office
Portion's medication is to treat the important method of canker sore.
In the present invention:
Reticuloendothelial system phagocytic endotoxin in the effects of Cortex Phellodendri has to antiendotoxin, antibacterial, antiviral and reinforcement
With the effect of internal non-specific immune function (main active is phellodendrine and magnoflorine).Cortex Phellodendri is in antibacterial and detoxicating
Angiogenesis can be effectively facilitated in the process, and diminish inflammation oedema, improves microcirculation, and wound healing and granulation tissue is promoted to generate;
Cow-bezoar is clearing heat and detoxicating key medicine, is usually used in abscess of throat caused by heat toxin, sore, carbuncle and painful swelling and some surgical diseases, often
Indigo naturalis etc. is cooperated to use;Effective component is indigo in indigo naturalis and indigo red, there is clearing heat and detoxicating, cooling blood and hemostasis and other effects;Lophatherum gracile, reed
Root clearing heat-fire;Radix scrophulariae clearing heat and cooling blood, detoxicating and resolving a mass;Catechu hygroscopic, myogenic, sore;Boric acid disinfection, sterilization, convergence.Multiple medicine closes
With, respectively play a role and mutually promote, have both prevention and treatment efficacy, collective effect in the canker sore surface of a wound, antibacterial of detoxifying,
Swelling and pain relieving is removed the rotten and let fresh grow.
Claims (5)
1. a kind of Chinese medicine composition for preventing and treating canker sore, it is characterised in that: the raw material including following weight parts composition:
20-40 parts of borax, 10-40 parts of Cortex Phellodendri, 5-35 parts of indigo naturalis, 5-20 parts of catechu, 6-25 parts of lophatherum gracile, 5-20 parts of reed root, radix scrophulariae 5-
20 parts, 5-15 parts of cow-bezoar.
2. a kind of Chinese medicine composition for preventing and treating canker sore according to claim 1, it is characterised in that: including under
State parts by weight composition raw material: 22-38 parts of borax, 15-35 parts of Cortex Phellodendri, 10-30 parts of indigo naturalis, 8-18 parts of catechu, lophatherum gracile 10-20
Part, 6-15 parts of reed root, 8-18 parts of radix scrophulariae, 6-14 parts of cow-bezoar.
3. a kind of Chinese medicine composition for preventing and treating canker sore according to claim 2, it is characterised in that: including under
State parts by weight composition raw material: 25-35 parts of borax, 20-30 parts of Cortex Phellodendri, 15-25 parts of indigo naturalis, 10-15 parts of catechu, lophatherum gracile 12-
18 parts, 8-12 parts of reed root, 10-15 parts of radix scrophulariae, 8-12 parts of cow-bezoar.
4. a kind of Chinese medicine composition for preventing and treating canker sore according to claim 3, it is characterised in that: including under
State the raw material of parts by weight composition: 30 parts of borax, 25 parts of Cortex Phellodendri, 20 parts of indigo naturalis, 12 parts of catechu, 15 parts of lophatherum gracile, 9 parts of reed root, profound
12 parts, 10 parts of cow-bezoar of ginseng.
5. a kind of preparation method for preparing claim 1 to the Chinese medicine composition described in any one of claim 4, feature exist
In: including following preparation step:
(1) each raw material of precise is formed according to parts by weight described in claim;
(2) raw material for having weighed weight is uniformly mixed in addition to borax, is heated to after being impregnated 0.5-1 hours with 5~20 times of amount water
Boiling is kept for slight boiling condition 0.5-1 hours, is cooled to 70-80 DEG C of filtering, and load weighted borax is added into filtrate, is stirred molten
Solution filtering, obtains filtrate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811586142.5A CN109432322A (en) | 2018-12-24 | 2018-12-24 | A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811586142.5A CN109432322A (en) | 2018-12-24 | 2018-12-24 | A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109432322A true CN109432322A (en) | 2019-03-08 |
Family
ID=65535160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811586142.5A Pending CN109432322A (en) | 2018-12-24 | 2018-12-24 | A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109432322A (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6077512A (en) * | 1993-10-13 | 2000-06-20 | Chen; Ren-Rong | Externally-applied medicine for curing black foot disease |
CN1279975A (en) * | 2000-07-11 | 2001-01-17 | 刘文功 | Medicine for curing stomatocase |
CN107929424A (en) * | 2017-10-30 | 2018-04-20 | 四川金堂海纳生物医药技术研究所 | A kind of powder agent medicine and preparation method for being used to treat recurrent oral ulceration |
-
2018
- 2018-12-24 CN CN201811586142.5A patent/CN109432322A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6077512A (en) * | 1993-10-13 | 2000-06-20 | Chen; Ren-Rong | Externally-applied medicine for curing black foot disease |
CN1279975A (en) * | 2000-07-11 | 2001-01-17 | 刘文功 | Medicine for curing stomatocase |
CN107929424A (en) * | 2017-10-30 | 2018-04-20 | 四川金堂海纳生物医药技术研究所 | A kind of powder agent medicine and preparation method for being used to treat recurrent oral ulceration |
Non-Patent Citations (1)
Title |
---|
张霞等: "消溃散治疗复发性口腔溃疡", 《中医药研究》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102139030B (en) | Oral Chinese herbal preparation for treating gingivitis and preparation method thereof | |
CN102178844A (en) | Oral Chinese medicine preparation for treating gum swelling and pain and preparation method thereof | |
CN108853287A (en) | Pharmaceutical composition, gel preparation and the application of a kind of anti-human papilloma virus (anti-HPV) and anti-gynaecological imflammation | |
CN105213941A (en) | A kind of Chinese medicine composition being used for the treatment of infantile diarrhea and preparation method thereof | |
CN103156984A (en) | Traditional Chinese medicine composition for treating gingivitis and preparation method thereof | |
CN105030620A (en) | Moisturizing and acne removing facial cleanser and preparing method thereof | |
CN103638316B (en) | Traditional Chinese medicine preparation for treating dermatitis | |
CN105194443A (en) | Traditional Chinese medicine composition for treating infantile eczema and preparation method of composition | |
CN109432322A (en) | A kind of Chinese medicine composition and preparation method thereof preventing and treating canker sore | |
CN106728069B (en) | Slough-removing and tissue regeneration-promoting paste for treating scalds and burns | |
CN105168091A (en) | Telangiectasis removing mask powder and preparation method thereof | |
CN105056078A (en) | Traditional Chinese medicine composition for treating stomach fire exuberance, toothache and ozostomia | |
CN104623304A (en) | Lotion for treating chronic skin ulcer caused by damp-heat and toxicity accumulation and preparation method of lotion | |
CN103432565A (en) | Gynaecological antiphlogistic and analgesic pharmaceutical formulation | |
CN115414427B (en) | Traditional Chinese medicine composition for treating chronic skin pruritus and preparation method and application thereof | |
CN104189608B (en) | Traditional Chinese medicine preparation for recurrent oral ulcer and preparation method thereof | |
CN103948709B (en) | Palace, a kind of Uygur medicine heat seal Meikang suppository and preparation method thereof | |
CN105688171B (en) | Feed additive for chicks and preparation method thereof | |
CN103860976B (en) | A kind of pharmaceutical composition for the treatment of infant's dermatitis | |
CN107648494A (en) | One kind treats gingivitis and canker sore Chinese medical collutory and preparation method thereof | |
CN105456708A (en) | Drug for treating cheilitis and preparation method thereof | |
CN104887808A (en) | Periodontitis treatment traditional Chinese medicine preparation | |
CN104998189A (en) | Traditional Chinese medicine powder for treating infantile oral ulcer of wind-heat spleen type and preparation method thereof | |
CN104800530A (en) | Traditional Chinese medicine composition for treating oral ulcer and preparation method of traditional Chinese medicine composition | |
CN104524305A (en) | Mouth wash relieving toothache and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190308 |
|
RJ01 | Rejection of invention patent application after publication |