CN109432201A - Gynaecologic antibiotic gel and preparation method thereof - Google Patents
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The present invention provides a kind of gynaecologic antibiotic gels, gynaecologic antibiotic gel is prepared using poloxamer, electrolysis-type silver ion antimicrobial agent, glycerol, wherein control the concentration of silver ions of electrolysis-type silver ion antimicrobial agent, cooperate in suitable content range with poloxamer and glycerol, it is formed and has slow release effect and can will adjust phase transition temperature and human body temperature adaptation, for a long time in the gel paste of intravaginal stop, while anti-microbial property can be played well.Also, it is antibacterial, bactericidal effect is more preferable after electrolysis-type silver ion antimicrobial agent, camomile extract and Flos Rosae Rugosae extract compounding, and cream gel is able to maintain for the adhesion property of vaginal walls, maintain long-time drug effect.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, more particularly to a kind of gynaecologic antibiotic gel and preparation method thereof.
Background technique
Gynaecologic antibiotic gel is a kind of gynaecology's drug, for various gynecology colpitis, the treatment of cervicitis, comprising: bacterium
Property vaginitis, trichomonas vaginitis, Combination vaginitis, gonococcal infection, chronic cervicitis, cervical erosion, have anti-inflammatory, kill
Bacterium, itching-relieving action.Gynaecologic antibiotic gel in the market is wide in variety, and formula is more, generally Chinese herbal medicine extract class antibacterial gel, packet
Containing ginseng, kuh-seng, Japanese Stephania Root, Cortex Phellodendri, aloe etc., the antibacterial gel of western medicine class have guanidine, cationic antibacterial agent class, acetic acid chlorine oneself
Fixed, chlorhexidine gluconate, benzalkonium chloride etc., the matrix of general gel are carbomer.But these traditional antibacterial gels, injection
When meeting salinity into the human body, electrolyte when to intravaginal, it is easy at once thinning, active drug is also having not enough time in intravaginal
Wall, which stops, to be played antibacterial action and is easy for nature outflow, leads to that gynecological gel effect is low, therapeutic effect is poor.
Summary of the invention
Based on this, it is necessary to which in view of the above-mentioned problems, providing, a kind of antibacterial action is good, can effectively stop for a long time in vagina
It stays and safe and non-toxic, non-stimulated gynaecologic antibiotic gel.
For achieving the above object, specific technical solution is as follows:
A kind of gynaecologic antibiotic gel, according to parts by weight, raw material includes following components:
The concentration of silver ion is 22~28ppm in the electrolysis-type silver ion antimicrobial agent.
Another object of the present invention, which also resides in, provides a kind of preparation method of above-mentioned gynaecologic antibiotic gel, particular technique side
Case is as follows:
A kind of preparation method of gynecological gel, comprising the following steps:
(1) raw material as described above is taken；
(2) poloxamer is added in deionized water, at 16~20 DEG C, stirring is to being completely dissolved to pellucidity；
(3) electrolysis-type silver ion antimicrobial agent, camomile extract, Flos Rosae Rugosae extract and glycerol is added, stirs evenly, i.e.,
?.
Based on the above-mentioned technical proposal, the invention has the following advantages:
Gynaecologic antibiotic gel is prepared using poloxamer, electrolysis-type silver ion antimicrobial agent, glycerol in the present invention, wherein controlling
The concentration of silver ions of electrolysis-type silver ion antimicrobial agent processed cooperates in suitable content range with poloxamer and glycerol, is formed
Have slow release effect and can will adjust phase transition temperature and human body temperature adaptation, for a long time in the paste solidifying of intravaginal stop
Glue, while anti-microbial property can be played well.Also, electrolysis-type silver ion antimicrobial agent, camomile extract and rose mention
It is antibacterial, bactericidal effect is more preferable after taking object to compound, and cream gel is able to maintain for the adhesion property of vaginal walls, when remaining long
Between drug effect.
Specific embodiment
To facilitate the understanding of the present invention, it below with reference to embodiment to invention is more fully described, is given below
Presently preferred embodiments of the present invention.But the invention can be realized in many different forms, however it is not limited to described herein
Embodiment.Purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.Embodiment
The middle all kinds of raw materials used are unless otherwise indicated commercial product.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Used term is intended merely to describe specific reality in the description of the invention
Apply the purpose of example, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more relevant institutes
Any and all combinations of list of items.
The present invention provides a kind of gynaecologic antibiotic gels, and according to parts by weight, raw material includes following components: poloxamer 8
~13 parts；90~110 parts of electrolysis-type silver ion antimicrobial agent；40~60 parts of camomile extract；15~25 parts of Flos Rosae Rugosae extract；
15~25 parts of glycerol；Wherein, the concentration of silver ion is 22~28ppm in the electrolysis-type silver ion antimicrobial agent.Poloxamer, electricity
Gynaecologic antibiotic gel is prepared in solution type silver ion antimicrobial agent, glycerol, wherein the silver ion of control electrolysis-type silver ion antimicrobial agent
Concentration cooperates in suitable content range with poloxamer and glycerol, and formation has slow release effect and can will adjust phase transformation
The gel paste that temperature and human body temperature are adapted to, stopped for a long time in intravaginal, while anti-microbial property can be played well.
Wherein, the concentration of silver ions in electrolysis-type silver ion antimicrobial agent plays an important role, on the one hand, concentration of silver ions is husky for pool Lip river
Stability, the adhesion property that nurse and glycerol form gel have an impact, on the other hand, the glycerol of proper ratio, poloxamer with
The silver ion of suitable concentration could more preferably play bactericidal effect, when concentration of silver ions is excessive or too small, the bactericidal effect of intravaginal
It is undesirable, only under suitable concentration of silver ions, cooperates with suitable poloxamer, suitable glycerol, can take into account
Need to have the effect of stability, adhesiveness and anti-microbial property.Preferably, the concentration of the silver ion is 24~26ppm, more excellent
It is selected as 25ppm.
Preferably, the poloxamer, electrolysis-type silver ion antimicrobial agent, glycerol ratio be 1:(9~11): (1~2)；
Under this suitable ratio, gel has good stability and vaginal walls adhesion property, while can be with reasonable rate
Sustained release silver ion and the natural antibacterial ingredient camomile extract and Flos Rosae Rugosae extract being used cooperatively reach stable and significant
Antibacterial effect, it is highly preferred that the ratio of the poloxamer, electrolysis-type silver ion antimicrobial agent, glycerol is 1:10:2.
Wherein, chamomile is generally used for alleviating the pain symptom including headache, neuralgia, toothache and otalgia, is also commonly used for
Mitigate premenstrual syndrome and involutional symptom；Flos Rosae Rugosae extract is also known as rose water essential oil, has and keeps the skin wet, is moisturizing, fast
Fast anti-inflammatory, antiallergy, it is antipruritic, delay senescence effect, while also pre- anti-wrinkle, color spot, delay skin aging, tranquilizing the mind, moisturizing,
It moisturizes the skin, intense strain of releiving, adjust the effects of physiology phase circulation, balance skin pH value.Gynaecology of the present invention is anti-
In bacterium gel, electrolysis-type silver ion antimicrobial agent, camomile extract and Flos Rosae Rugosae extract three are compounded with proper ratio, no
Stronger antibacterial, bactericidal effect can be only played, is also beneficial to women physical and mental health applied to gynaecology.Preferably, by weight
Number count the electrolysis-type silver ion antimicrobial agent, the camomile extract and the Flos Rosae Rugosae extract usage ratios be (9~
11): (4~6): 2.
It is further preferred that the ratio of the PLURONICS F87 and the poloxamer188 is (9~11): 1, in this ratio
In example range, the stability of gelling agent, adhesiveness and anti-microbial property are best.More electedly, the PLURONICS F87 and the pool
The ratio of Luo Shamu 407 is 9:1.On the one hand, poloxamer is as emulsifier and stabilizer, and uniform stable emulsifying is matched in gel
Oily material in side, while being undergone phase transition under body temperature as slow-release material, there is stronger adhesiveness to vagina
Can, slow release effect is played to antibacterial compound.On the other hand, gynaecologic antibiotic gel is enabled to rest on intravaginal for a long time,
It is good with the compatibility of vaginal mucosa, it is nonirritant, while also can increase cutaneous permeability, facilitate deep layer sterilization.
The present invention also provides a kind of preparation methods of gynecological gel, comprising the following steps: (1) takes original as described above
Material；(2) poloxamer is added in deionized water, at 16~20 DEG C, stirring is to being completely dissolved to pellucidity；(3) it is added
Electrolysis-type silver ion antimicrobial agent, camomile extract, Flos Rosae Rugosae extract and glycerol, stir evenly to get.
Wherein, raw material sources information described in the present embodiment are as follows:
Electrolysis-type silver ion antimicrobial agent: being provided, model 76000-AG-25 by Guangzhou Bo Feng Chemical Industry Science Co., Ltd,
Product batch number is 2016-2-1/160312.
Camomile extract: it is purchased from positive standing grain (Guangzhou) Biotechnology Co., Ltd, article No.: L1-CY1080, No. CAS:
84649-86-5。
Flos Rosae Rugosae extract: it is purchased from positive standing grain (Guangzhou) Biotechnology Co., Ltd, article No.: L1-CY1043, No. CAS:
90106-38-0。
Embodiment 1
A kind of gynaecologic antibiotic gel of the present embodiment and preparation method thereof, according to parts by weight, raw material includes following components:
Wherein, the concentration of silver ion is 25ppm in the electrolysis-type silver ion antimicrobial agent；
Using above-mentioned raw materials prepare gynaecologic antibiotic gel the preparation method is as follows:
PLURONICS F87, poloxamer188 are added in deionized water, wherein PLURONICS F87 and poloxamer188
Total weight, the ratio with the deionized water being added, in terms of g/ml, be 1:80.After mixing evenly, using homogenizer, 18
At DEG C, be completely dissolved to pellucidity, add electrolysis-type silver ion antimicrobial agent, camomile extract, Flos Rosae Rugosae extract and
Glycerol stirs evenly, at clear solution, it is filling to get.
Embodiment 2
A kind of gynaecologic antibiotic gel of the present embodiment and preparation method thereof, according to parts by weight, raw material includes following components:
Wherein, the concentration of silver ion is 27ppm in the electrolysis-type silver ion antimicrobial agent；
Preparation method is same as Example 1.
Embodiment 3
A kind of gynaecologic antibiotic gel of the present embodiment and preparation method thereof, according to parts by weight, raw material includes following components:
Wherein, the concentration of silver ion is 25ppm in the electrolysis-type silver ion antimicrobial agent；
Preparation method is same as Example 1.
Comparative example 1
A kind of gynaecologic antibiotic gel of this comparative example and preparation method thereof, compared with Example 1, difference only exists raw material components
Concentration of silver ions is 35ppm in this comparative example, remaining component and preparation method are same as Example 1.
Comparative example 2
A kind of gynaecologic antibiotic gel of this comparative example and preparation method thereof, compared with Example 1, difference only exists raw material components
Concentration of silver ions is 18ppm in this comparative example, remaining component and preparation method are same as Example 1.
Comparative example 3
This is to one of example gynaecologic antibiotic gel and preparation method thereof, and compared with Example 1, difference only exists raw material components
PLURONICS F87 and poloxamer188 are not used in this comparative example, but use carbomer, remaining component and preparation method
It is same as Example 1.
Comparative example 4
A kind of gynaecologic antibiotic gel of this comparative example and preparation method thereof, compared with Example 1, difference only exists raw material components
Electrolysis-type silver ion antimicrobial agent dosage is 90 parts in this comparative example, camomile extract dosage is 70 parts, Flos Rosae Rugosae extract
Dosage is 15 parts, remaining component and preparation method are same as Example 1.
Experimental example 1
According to GB15979-2002 Disposable Sanitary Accessory sanitary standard appendix C (product bactericidal property, bacteriostasis property
With stability test method), bactericidal effect test is carried out respectively to silver ion antimicrobial agent, embodiment 1-3, comparative example 1-5.Test
Project is sterilizing rate, and test bacterium bag includes Escherichia coli 8099, staphylococcus aureus ATCC 6538, pseudomonas aeruginosa ATCC
15442, Candida albicans ATCC 10231, B-mode salmonella typhi CMCC 50094.The results are shown in Table 1.
Table 1 sterilizes test result
As seen from the above table, the gynaecologic antibiotic gel of 1-3 of the embodiment of the present invention is to Escherichia coli 8099, staphylococcus aureus
ATCC 6538, pseudomonas aeruginosa ATCC 15442, Candida albicans ATCC 10231, B-mode salmonella typhi CMCC
50094 all have good antibacterial effect, and sterilizing rate is up to 98% or more.And the bactericidal effect of comparative example 1-4 is poor, the reason is that one
The excessively high viscosity for affecting poloxamer and glycerol formation gel of concentration of silver ions in aspect comparative example 1, can not exist for a long time
It stops in vivo, it on the other hand, can not when concentration of silver ions is too high or too low in the silver ion antimicrobial agent of comparative example 1 and comparative example 2
Stable delivery system is formed under reasonable cooperation with poloxamer and glycerol, antibacterial action weakens significantly, silver-colored in comparative example 4
Ion antibacterial agent, the proportion of camomile extract and Flos Rosae Rugosae extract and dosage in the reasonable scope, be not prepared into gel
Afterwards, it is unable to give full play effective antibacterial action when three rationally compounds.
Experimental example 2
According to disinfection technology standard (version in 2002) the method, to silver ion antimicrobial agent used in the present invention and implementation
Gynecological gel described in example 1 is detected.
Using animal strains: new zealand rabbit, regular grade；
Animal origin: Tongxiang Yinhai Rabbit Cooperative provides, and production licence number is SCXK (Zhejiang) 2013-
0056；
Feeding environment: regular grade animal house, 20.3~23.2 DEG C of temperature, relative humidity 56.3%~67.2%.
The results are shown in Table 1 for irritant test, in which:
The stimulate the reaction integral addition/observation at 3 positions of average integral=3 animal is total (number of animals × 3)；
Stimulus index=silver ion antimicrobial agent group average integral-blank control group average integral
1 Results of Tests For Irritating Effects of table
As seen from the above table, the stimulus index of silver ion antimicrobial agent group is 0.22, and the stimulus index of gynecological gel group is 0,
As it can be seen that silver ion antimicrobial agent group and the equal absence of vagina irritation on mucous membrane of gynecological gel group.
Experimental example 3
The external biological adherency evaluation method and biology Nian Futi of authority and systematization are not yet formed in currently available technology
Outer correlation theory, therefore, the characteristics of in experimental example of the present invention according to vagina administration, using 21 healthy absence of vagina diseases
Wistar female mice (about 250g), is randomly divided into 7 groups, corresponding embodiment 1~3 and comparative example 1~4, and every group 3, each mouse intravaginal
It is injected separately into each 0.25ml of gelling agent that each group is prepared, adherency and delay after observation each group gelling agent injection rat vagina
Situation.The results show that all rats are not seen after the gel injection rat vagina of Examples 1 to 3, comparative example 2 and comparative example 4
It observes any liquid or gel state fluid to flow out from vagina, illustrates PLURONICS F87 in embodiment, poloxamer188 and sweet
Oil, under suitable proportion, so that the gelling agent containing suitable concentration of silver ions has preferable adhesiving effect, and in rat yin
It under the action of road body temperature, undergoes phase transition, the adhesion property of vagina is significantly reinforced making it possible to effectively be stranded in intravaginal.
And after comparative example 1 injects rat vagina, observe that wherein 2 rats have a small amount of liquid outflow, 1 rat to have more
Liquid outflow, although reason may be in comparative example 1 also containing PLURONICS F87, poloxamer188 and glycerol in rat
It is undergone phase transition under body temperature, increases the viscosity and adhesion property of gelling agent down to a certain degree, but due to its concentration of silver ions mistake
Greatly, the stability of gelling agent is still affected to a certain extent, so that gelling agent described in comparative example 1 is after injecting rat vagina
Have a small amount of liquid outflow vagina.
After 3 gel of comparative example is injected rat vagina, observe that gelling agent almost all flows out, the reason is that not using pool
The cooperation of Luo Shamu 188, poloxamer188 and glycerol, gelling agent viscosity very little can not be mutually deformed into good adhesiveness
The colloid substance of energy, is still within very dilute state, is difficult to be detained in intravaginal, it is easy to flow out from vagina.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of gynaecologic antibiotic gel, which is characterized in that according to parts by weight, raw material includes following components:
The concentration of silver ion is 22~28ppm in the electrolysis-type silver ion antimicrobial agent.
2. described in any item gynaecologic antibiotic gels according to claim 1, which is characterized in that the poloxamer, electrolysis-type silver
Ion antibacterial agent, glycerol ratio be 1:(9~11): (1~2)；
The poloxamer is the compound of PLURONICS F87 and poloxamer188.
3. gynaecologic antibiotic gel according to claim 2, which is characterized in that according to parts by weight, the silver ion it is dense
Degree is 24~26ppm.
4. gynaecologic antibiotic gel according to claim 3, which is characterized in that the concentration of the silver ion is 25ppm.
5. described in any item gynaecologic antibiotic gels according to claim 1~3, which is characterized in that according to parts by weight, the pool
The usage ratio of Luo Shamu 188 and the poloxamer188 is (9~11): 1.
6. gynaecologic antibiotic gel according to claim 5, which is characterized in that according to parts by weight, the PLURONICS F87
Usage ratio with the poloxamer188 is 9:1.
7. gynaecologic antibiotic gel according to claim 1, which is characterized in that according to parts by weight, the electrolysis-type silver from
Sub- antibacterial agent, the camomile extract, the usage ratio of the Flos Rosae Rugosae extract are (9~11): (4~6): 2.
8. gynaecologic antibiotic gel according to claim 7, which is characterized in that according to parts by weight, the electrolysis-type silver from
Sub- antibacterial agent, the camomile extract, the usage ratio of the Flos Rosae Rugosae extract are 10:5:2.
9. gynaecologic antibiotic gel according to claim 8, which is characterized in that according to parts by weight, raw material includes with the following group
Point:
The concentration of the silver ion is 25ppm.
10. a kind of preparation method of gynecological gel, which comprises the following steps:
(1) by described in any one of claim 1~9, prepare raw material；
(2) poloxamer is added in deionized water, at 16~20 DEG C, stirring is to being completely dissolved to pellucidity；
(3) electrolysis-type silver ion antimicrobial agent, camomile extract, Flos Rosae Rugosae extract and glycerol is added, stir evenly to get.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917339A (en) * | 2019-12-27 | 2020-03-27 | 遵义医学院附属医院 | Lysostaphin gel and application thereof in MRSA infected wound surface |
| CN112957315A (en) * | 2021-02-18 | 2021-06-15 | 博凯药业有限公司 | Personal care gel, preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998051273A1 (en) * | 1997-05-12 | 1998-11-19 | Sage Pharmaceuticals, Inc. | Topical spray for burn treatment and anti-infection |
| CN101491541A (en) * | 2009-02-25 | 2009-07-29 | 中山大学 | Thermosensitive gel type nano silver foam aerosol for women and preparation method thereof |
| CN108158975A (en) * | 2018-01-12 | 2018-06-15 | 吉林大学 | Antimycotic sustained release thermo-responsive hydro gel of stannic oxide/graphene nano silver Terbinafine and its preparation method and application |
-
2018
- 2018-12-29 CN CN201811647304.1A patent/CN109432201B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998051273A1 (en) * | 1997-05-12 | 1998-11-19 | Sage Pharmaceuticals, Inc. | Topical spray for burn treatment and anti-infection |
| CN101491541A (en) * | 2009-02-25 | 2009-07-29 | 中山大学 | Thermosensitive gel type nano silver foam aerosol for women and preparation method thereof |
| CN108158975A (en) * | 2018-01-12 | 2018-06-15 | 吉林大学 | Antimycotic sustained release thermo-responsive hydro gel of stannic oxide/graphene nano silver Terbinafine and its preparation method and application |
Non-Patent Citations (3)
| Title |
|---|
| 无: "抗菌的洋甘菊提取物用于***冲洗", 《国外医药 植物药分册》 * |
| 阿瓦汗等: "维药玫瑰花油治疗老年性***炎196例临床体会", 《中国民族民间医药杂志》 * |
| 陈美婉: "***用纳米银温敏喷雾凝胶的研究", 《万方学位》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917339A (en) * | 2019-12-27 | 2020-03-27 | 遵义医学院附属医院 | Lysostaphin gel and application thereof in MRSA infected wound surface |
| CN112957315A (en) * | 2021-02-18 | 2021-06-15 | 博凯药业有限公司 | Personal care gel, preparation method and application |
| CN112957315B (en) * | 2021-02-18 | 2023-01-31 | 博凯药业有限公司 | Personal care gel, preparation method and application |
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