CN109431908A - Skin whitening, moisturizing frost and preparation method thereof and skin-lightening cosmetic additive - Google Patents
Skin whitening, moisturizing frost and preparation method thereof and skin-lightening cosmetic additive Download PDFInfo
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- CN109431908A CN109431908A CN201811603394.4A CN201811603394A CN109431908A CN 109431908 A CN109431908 A CN 109431908A CN 201811603394 A CN201811603394 A CN 201811603394A CN 109431908 A CN109431908 A CN 109431908A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention provides a kind of skin whitening, moisturizing frost and preparation method thereof and skin-lightening cosmetic additive.The skin whitening, moisturizing frost includes skin-lightening cosmetic additive, and in terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the skin-lightening cosmetic additive is 0.01-15%；The skin-lightening cosmetic additive includes ginseng extract and mint extract.The formula of skin whitening, moisturizing frost of the invention is mild, can effectively inhibit the activity of tyrosinase, to play the role of whitening.Further, skin-lightening cosmetic additive of the invention is excellent to the inhibiting effect of tyrosinase activity and without side-effects to human body.
Description
Technical field
The present invention relates to a kind of skin whitening, moisturizing frosts and preparation method thereof and skin-lightening cosmetic additive, belong to cosmetics neck
Domain.
Background technique
Melanin (Melanin) is mainly generated by the melanocyte (Melanocyte) of human skin basal layer of epidermis,
It can reduce injury of the ultraviolet light to skin.The content of melanin and distribution determine the color of skin.However, melanin is in base
The abnormal accumulation of bottom will cause hyperpigmentation and cause black spot, freckle, senile plaque etc., influence people's lives quality.
As that studies melanin biosynthesis deepens continuously, researcher has found that tyrosinase plays the part of weight in melanin biosynthesis
Role is wanted, it is the major rate-limiting enzyme of tyrosine and DOPA into melanin transition process, its overexpression is to lead to pigment
The main reason for calm excessive.Therefore, inhibit the activity of tyrosinase that can block the biosynthesis reaction chain of melanin, reduce
The effect of whitening is realized in the generation of melanin.
For the approach and influence factor of melanin production, the main path of skin-whitening and skin nursing includes following several
A aspect: (1) by inhibit dermal melanin cell Proliferation, the quantity that melanocyte generates is reduced；(2) by inhibiting skin
Key enzyme-tyrosinase catalytic activity of melanin production, reduces the biosynthesis of melanin, achievees the purpose that whitening；(3)
By sun-proof, prevent sunlight middle-ultraviolet lamp from slowing down skin aging to the injury (tanned and sunburn) of skin；(4) be by using
Antioxidant removes the oxygen radical in skin, slows down melanin production and slows down skin aging.
In the prior art, skin darkening, spot, freckle etc. in order to prevent keep original pure white of skin, there has been proposed
It is mixed with the skin-lightening cosmetic of the various whitening agents such as quinhydrones, kojic acid, arbutin.But if largely mixing these substances, sometimes
It is led to the problem of in use feeling and safety.As irritation of the quinhydrones to skin is very big；Kojic acid is easy to change and also has to skin
Certain irritation；Arbutin acts on single and ineffective etc..
As people increase skin health attention rate, develop with safety and stability, effect is obvious and cost performance is high
Natural whitening agent, it has also become one of the main direction of studying of current medicine and cosmetic industry has extraordinary development prospect.
Summary of the invention
Problems to be solved by the invention
In view of in the prior art, quinhydrones is very big to the irritation of skin；Kojic acid is easy to change and also has to skin certain
Irritation；The problems such as arbutin effect is single and ineffective, present invention firstly provides a kind of skin whitening, moisturizing frosts.It is formulated temperature
With can effectively inhibit the activity of tyrosinase, to play the role of whitening.
Further, the inhibition the present invention also provides a kind of skin-lightening cosmetic additive of the invention to tyrosinase activity
It acts on excellent and without side-effects to human body.
Further, the present invention also provides a kind of easy to operate, preparation methods for the skin whitening, moisturizing frost that raw material is easily obtained.
The solution to the problem
The present invention provides a kind of skin whitening, moisturizing frost comprising skin-lightening cosmetic additive, with the total of the skin whitening, moisturizing frost
Quality meter, the additional amount of the skin-lightening cosmetic additive are 0.01-15%；The skin-lightening cosmetic additive includes that ginseng mentions
Take object and mint extract.
Skin whitening, moisturizing frost according to the present invention, wherein the skin whitening, moisturizing frost further includes moisturizer, thickener, pH adjusting
Agent, grease, emulsifier, skin conditioning agent, antioxidant and chelating agent；Wherein, in terms of the gross mass of the skin whitening, moisturizing frost, institute
The additional amount for stating moisturizer is 0.01-20%；The additional amount of the thickener is 0.02-5%；The additional amount of the pH adjusting agent
For 0.01-1%；The additional amount of the grease is 10-30%；The additional amount of the emulsifier is 0.01-5%；The skin tune
The additional amount for managing agent is 0-10%；The additional amount of the antioxidant is 0.01-2%；The additional amount of the chelating agent is 0.01-
1%.
Skin whitening, moisturizing according to the present invention frost, wherein the moisturizer includes propylene glycol, butanediol, panthenol, double third sweet
The combination of one or more of alcohol, glycerol, glycerine polyacrylate, Sodium Hyaluronate, trehalose；And/or
The grease includes isopropyl myristate, dimethyl silicone polymer, ring five dimethyl silicone polymer, the octanoic acid/last of the ten Heavenly stems
Acid glycerol three ester, oleyl alcohol eruciate, Parleam, Butyrospermum parkii fruit rouge, ethylhexyl palmitate, Nexbase 2004, ring
Own siloxanes, C20-24 alkyl dimethicone, C13-14 isoparaffin, C12-15 alcohol benzoic ether, oil with hydrogenated soybean,
The combination of one or more of phytosterol, olive oil unsaponifiable matter.
Skin whitening, moisturizing frost according to the present invention, wherein the emulsifier includes the pure and mild cetearyl glucose of cetearyl alcohol
The compound of glycosides, the compound of PEG-100 stearate and stearine, sorbitan sesquioleate and isooctadecanol are poly-
Compound, PEG-10 campesterol, laureth -7, the polyglycereol-3-methyl distearate, PEG/ of ether -20
PPG-10/1 dimethyl silicone polymer, polyglyceryl-3 diisostearate, stearine, stereth -20, cetanol
The combination of one or more of the combination of one or more of polyethers -20, polysorbate -60；And/or
The pH adjusting agent include aminomethyl propanol, arginine, citric acid, sodium citrate, sodium hydroxide, in potassium hydroxide
A combination of one or more.
Skin whitening, moisturizing frost according to the present invention, wherein the thickener includes carbomer, xanthan gum, polydimethylsiloxanes
Alkane/vinyl dimethicone cross polymer, docosyl alcohol, polyacrylamide, ammonium acryloyldime-thyltaurate/VP are total
The combination of one or more of polymers, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers；And/or
The antioxidant includes vitamin E, tocopherol acetate, Butylated Hydroxytoluene, lycopene, ascorbic acid ethylether
One or more of combination.
Skin whitening, moisturizing frost according to the present invention, wherein the skin conditioning agent includes two section shepherd's purse seed oil of deep-sea, brown alga extraction
Object, palmitoyl oligopeptide, magnesium aminosuccinate, Cer NS, bulk kelp extract, allantoin, Hydrolyzed Collagen, sea lettuce extract,
One of Colloidal oatmeal, beta glucan, heartsease extract, PEG-10 campesterol, chlorella tunning or two
Kind or more combination；And/or
The chelating agent includes EDTA-2Na and/or EDTA-4Na.
Skin whitening, moisturizing frost according to the present invention, wherein in terms of the gross mass of the skin-lightening cosmetic additive, the ginseng
The additional amount of extract is 0.1-80%, and the additional amount of the mint extract is 20-99.9%.
Skin whitening, moisturizing according to the present invention frost, wherein the mass ratio of the ginseng extract and the mint extract is
1:0.4~75, preferably 1:1~70, more preferably 1:1.5~65, further preferably 1:2~60, still more preferably for
1:2.5~57, much further preferably from 1:3~55.
The present invention also provides a kind of preparation methods of skin whitening, moisturizing frost according to the present invention, wherein including by the whitening
The step of each component mixing of moisturiser.
The present invention also provides a kind of skin-lightening cosmetic additives comprising ginseng extract and mint extract, with described
The gross mass meter of skin-lightening cosmetic additive, the additional amount of the ginseng extract are 0.1-80%, the mint extract
Additional amount is 20-99.9%；Preferably,
The mass ratio of the ginseng extract and the mint extract is 1:0.4~75, and preferably 1:1~70 are more excellent
Be selected as 1:1.5~65, further preferably 1:2~60, be still more preferably 1:2.5~57, much further preferably from 1:3~
55。
The effect of invention
The formula of skin whitening, moisturizing frost of the invention is mild, can effectively inhibit the activity of tyrosinase, to play whitening
Effect.
Further, skin-lightening cosmetic additive of the invention is excellent to the inhibiting effect of tyrosinase activity, and to people
Body is without side-effects.
Further, the preparation method of skin whitening, moisturizing frost of the invention is easy to operate, and raw material is easily obtained, and can be criticized
Amount production.
Detailed description of the invention
Fig. 1 shows logarithm mass concentration-tyrosinase inhibition rate pass of the ginseng extract of comparative example 1-5 of the present invention
System's figure；
Fig. 2 shows logarithm mass concentration-tyrosinase inhibition rates of the mint extract of comparative example 6-10 of the present invention
Relational graph；
Logarithm mass concentration-tyrosinase that Fig. 3 shows the skin-lightening cosmetic additive of 1-7 of the embodiment of the present invention inhibits
The relational graph of rate.
Fig. 4 shows the content of ginseng extract and phase interaction in the skin-lightening cosmetic additive of 1-7 of the embodiment of the present invention
With the relational graph of coefficient.
Fig. 5 shows the comparison diagram of the melanin change rate of Application Example 1-8 of the present invention and Comparison study example 1-2.
Specific embodiment
It will be detailed below various exemplary embodiments, feature and aspect of the invention.Dedicated word " example herein
Property " mean " being used as example, embodiment or illustrative ".Here as any embodiment illustrated by " exemplary " should not necessarily be construed as
Preferred or advantageous over other embodiments.
In addition, in order to better illustrate the present invention, numerous details is given in specific embodiment below.
It will be appreciated by those skilled in the art that without certain details, the present invention equally be can be implemented.In other example,
Method well known to those skilled in the art, means, equipment and step are not described in detail, in order to highlight master of the invention
Purport.
First embodiment
First embodiment of the invention provides a kind of skin-lightening cosmetic additive, comprising: ginseng extract and peppermint mention
Take object.Skin-lightening cosmetic additive of the invention can be good at inhibiting the activity of tyrosinase, in use, energy in cosmetics
Enough there is excellent whitening effect.
Peppermint (Mentha haplocalyx Briq) is Labiatae perennial root Mentha herbaceous plant, You Mingshui
Peppermint, HERBA MENTHAE, luxuriant lotus leaf etc..Peppermint is that China is common and important, one of the extensive traditional spice berry of cultivated area,
Part can be used as medicine on peppermint, and complete stool has strong cooling fragrance, and being that one kind is widely distributed, adaptability is extremely strong has strong spy
The plant of different aromatic odor.
Volatile oil in mint plants is the main chemical compositions in peppermint, studies the element of the first species the most deep.Research
Show that the main chemical compositions in oil are alcohol, ketone, ester, terpane, terpene compound.Contain volatile oil in the fresh blade of peppermint
About 0.8~1%, scapus leaf contains about 1.3~2%.
In addition, mint is widely distributed, ecologic adaptation power is strong, and form and chemical component exist compared with multi-Vari, leads
Cause the peppermint oil component difference extracted very big.The fixed oil ingredient of peppermint include: amino acid, Flavonoid substances, organic acid and
Fatty acid etc..In addition, further including inorganic elements, vitamin, carrotene, malol etc..
Ginseng (Panax ginseng C.A.Meyer) is Araliaceae (Araliaceae) herbaceos perennial, ginseng
It is one of the resources of medicinal plant of Changbai Mountain most potentiality to be exploited.
Chemical component there are many containing in ginseng, such as: ginsenoside, panaxan, ginseng protein and polypeptide etc..Wherein,
Ginsenoside (Ginsenoside) is a kind of steroid compound, is with dammarane type, with Fourth Ring in chemical structure
Triterpene is the triterpenoid saponin of primary structure.Ginsenoside is one of the representative active constituent in ginseng, is widely present in ginseng
In platymiscium.Panaxan is other a kind of effective active composition of ginseng, is good natural effective component.Panaxan
With small-molecule chemical therapeutic agent use in conjunction, destruction of the chemotherapeutic agent to human immune system can be repaired and reduce,
Play the effect of Synergy and attenuation.
Ginseng extract can be used as a kind of natural additive for Cosmetic Manufacture.Ginsenoside has anti-oxidant, anti-purple
The effects of outside line, protection skin, be one of the physiological activator in ginseng.Ginsenoside can also stimulate skin fibroblasts
Activity, promote collagen synthesis, so that skin is tended to rejuvenation, so that the process of delay skin aging, plays its anti-aging
Effect, and increase SOD content and activity in skin simultaneously in a certain range.Content of ginsenoside is higher in ginseng extract
When, DPPH (1,1- diphenyl -2- trinitrophenyl-hydrazine) free radical can be removed.
The present invention uses the combination of ginseng extract and mint extract, and the two has synergistic effect, can further increase
Add the effect inhibited tyrosinase activity.In the present invention, in terms of the gross mass of the skin-lightening cosmetic additive, the ginseng
The additional amount of extract is 0.1-80%, and the additional amount of the mint extract is 20-99.9%.
In the present invention, the mass ratio of the ginseng extract and the mint extract be 1:0.4~75, preferably 1:
1~70, more preferably 1:1.5~65, further preferably 1:2~60 are still more preferably 1:2.5~57, further
Preferably 1:3~55.When the mass ratio of ginseng extract and mint extract within the above range when, can further have association
Same-action, the excellent effect inhibited tyrosinase activity.
Second embodiment
Second embodiment of the present invention provides a kind of skin whitening, moisturizing frost comprising first embodiment of the invention
Skin-lightening cosmetic additive.In terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the skin-lightening cosmetic additive is
0.01-15% preferably can be 0.1-10%, such as: 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% etc..When
When the additional amount of skin-lightening cosmetic additive is between 0.01-15%, melanin content in the skin after skin whitening, moisturizing frost is used
It reduces.The present invention is able to suppress the activity of tyrosinase, to play excellent by adding skin-lightening cosmetic additive of the invention
Different whitening effect.
The skin whitening, moisturizing frost further includes moisturizer, thickener, pH adjusting agent, grease, emulsifier, skin conditioning agent, resists
Oxidant and chelating agent.The formula composition of skin whitening, moisturizing frost of the invention is mild, and skin-lightening cosmetic of the invention can be made to add
The effect of agent, is not fully exerted.Specifically:
In terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the moisturizer is 0.01-20%.When adding for moisturizer
Enter amount in 0.01-20%, moisture-keeping function can be played.The effect of in order to enable moisturizer, further plays, of the invention
The additional amount of moisturizer can be 1-18%, can be 3-16%, can be 5-14%, can be 6-12%, such as: 2%,
3%, 6%, 8%, 10%, 12%, 15%, 17%, 19% etc..
In the present invention, the moisturizer includes propylene glycol, butanediol, panthenol, dipropylene glycol, glycerol, glycerol polypropylene
The combination of one or more of acid esters, Sodium Hyaluronate, trehalose.
In terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the thickener is 0.02-5%.It is thickened by addition
Agent can make the consistency of skin whitening, moisturizing frost of the invention suitable.Preferably, the additional amount of thickener of the invention can be
0.05-4% can be 0.1-3%, can also be 1-3% etc..
In the present invention, the thickener includes carbomer, xanthan gum, dimethyl silicone polymer/vinylpolydimethyl
Dimethicone Crosspolymer, docosyl alcohol, polyacrylamide, ammonium acryloyl taurate/VP copolymer, acrylic acid hydroxyl second
The combination of one or more of ester/sodium acryloyldimethyl taurate copolymers.
In terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the pH adjusting agent is 0.01-1%.By adding pH
Regulator makes the pH value human skin preferably of skin whitening, moisturizing frost.Preferably, the additional amount of pH adjusting agent of the invention can be with
It is 0.03-0.8%, can be 0.05-0.5%, can be 0.06-0.3% etc..When pH adjusting agent additional amount be greater than 1% or
When person is less than 0.01%, the suitable skin whitening, moisturizing frost of pH value cannot be obtained.
In the present invention, the pH adjusting agent includes aminomethyl propanol, arginine, citric acid, sodium citrate, hydroxide
The combination of one or more of sodium, potassium hydroxide etc..
In terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the grease is 10-30%, for example, the grease plus
Entering amount can be 12%, 15%, 18%, 20%, 12%, 25%, 28% etc..It, can by adding grease in skin whitening, moisturizing frost
To reduce the evaporation of skin surface moisture, chapped skin is prevented.In addition, can be formed in skin surface thin by addition grease
Aqueous film prevents the intrusion of harmful environmental substance.When the content of grease is less than 10%, skin surface moisture not can be reduced
Evaporation, and not can effectively prevent the intrusion of harmful substance；When the content of grease is greater than 30%, keep skin whitening, moisturizing frost excessively oily
Greasy, use feeling can be declined.
In the present invention, the grease includes isopropyl myristate, dimethyl silicone polymer, five polydimethylsiloxanes of ring
Alkane, caprylic/capric triglyceride, oleyl alcohol eruciate, Parleam, Butyrospermum parkii fruit rouge, ethylhexyl palmitate, hydrogenation
Poly decene, cyclohexasiloxane, C20-24 alkyl dimethicone, C13-14 isoparaffin, C12-15 alcohol benzoic ether, hydrogen
Change the combination of one or more of soybean oil, phytosterol, olive oil unsaponifiable matter.
In the present invention, in terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the emulsifier is 0.01-5%, example
Such as: can be 0.1-5%, can be 1-4% etc..When the emulsifier of the application is less than 0.01%, cause to emulsify insufficient
So that system is unstable；When emulsifier is greater than 5%, certain influence can be will also result in the stability of product.
In the present invention, the emulsifier includes the compound of the pure and mild cetearyl glucoside of cetearyl alcohol, PEG-100
The compound of stearate and stearine, the compound of sorbitan sesquioleate and isosteareth -20, PEG-
10 campesterols, laureth -7, polyglycereol-3-methyl distearate, PEG/PPG-10/1 polydimethylsiloxanes
Alkane, polyglyceryl-3 diisostearate, stearine, stereth -20, ceteth -20, polysorbate -
The combination of one or more of one or more of 60 combination.
In addition, present invention preferably uses the compounds of the pure and mild cetearyl glucoside of cetearyl alcohol, PEG-100 stearic acid
One of compound of the compound of ester and stearine, sorbitan sesquioleate and isosteareth -20 or
Two or more combinations are as emulsifier, to keep the emulsification of skin whitening, moisturizing frost more abundant, and excellent in stability.
In order to further increase the application skin whitening, moisturizing frost effect, skin whitening, moisturizing frost of the invention also includes described
Skin conditioning agent.By adding skin conditioning agent, can calm skin, to have work of centainly releiving to facial skin injury redness
With the generation of wrinkle can also be reduced.Effective component in skin conditioning agent can penetrate into skin depths, be absorbed by the skin,
So as to improve the state of skin.
In terms of the gross mass of the skin whitening, moisturizing frost, the additional amount of the skin conditioning agent is 0-10%.The skin tune
The additional amount of reason agent can be 0.01-8%, can be 0.5-5%, can be 0.9-3% etc..
The skin conditioning agent includes two section shepherd's purse seed oil of deep-sea, brown alga extract, palmitoyl oligopeptide, magnesium aminosuccinate, mind
Through amide 2, bulk kelp extract, allantoin, Hydrolyzed Collagen, sea lettuce extract, Colloidal oatmeal, beta glucan, heartsease
The combination of one or more of extract, PEG-10 campesterol, chlorella tunning.
Wherein, active smegma can be inhibited while improving sebum film using Cer NS, keeps skin water oily
Balance enhances the self-protection function of skin, is relatively suitble to skin greasing and has the young skin of demand.The ingredient is to skin moisturizing
Maintenance has good action, is skin-active ingredient important in cuticula, can enhance skin barrier, reconstituted cell.
Wherein, the effects of beta glucan is natural plant glycan, and the ingredient is anti-inflammatory there are also certain antiallergic.Beta glucan energy
There are preferable compatibility, no allergic reaction with most of raw materials, moreover it is possible to improve skin moisture-keeping ability.In addition, β-Portugal in the present invention
Glycan can also play the role of anti-oxidant and protect the skin from uv damage, can reduce wrinkle of skin, improve skin and support
The ability of imperial external injury.
Wherein, sea lettuce extract is the thallophytic active constituent of Ulvaceae plant sea lettuce or U. pertusa.Sea lettuce extract
Containing a variety of unsaturated fatty acids, aldehyde (such as citral) ingredient.Sea lettuce extract has the benefits of sterilization, moistening skin-care.
The present invention can reduce the irritation of skin whitening, moisturizing frost using Colloidal oatmeal, can alleviate the pruritus of skin
Shape, as anti-inflammatory, it is antipruritic and mitigate erythema purposes carry out using.
Skin whitening, moisturizing frost of the invention can also be properly added antioxidant and chelating agent.In general, with the beauty
The gross mass meter of white moisturiser, the additional amount of the antioxidant are 0.01-2%；The additional amount of the chelating agent is 0.01-
1%.The antioxidant can be vitamin E, tocopherol acetate, Butylated Hydroxytoluene, lycopene, ascorbic acid ethylether etc.
One or more of combination.The chelating agent can be EDTA-2Na and/or EDTA-4Na etc..
In addition, also including preservative and aromatic in skin whitening, moisturizing frost of the invention.With the total of the skin whitening, moisturizing frost
Quality meter, the additional amount of the preservative are 0.01-1.5%；The additional amount of the aromatic is 0.01-1%.The preservative
It may include the combination of one or more of Phenoxyethanol, methyl hydroxybenzoate, Nipasol, benzoic acid and its salt.It is described
Aromatic can be essence etc..
Third embodiment
Third embodiment of the present invention provides a kind of preparation method of the skin whitening, moisturizing frost of second embodiment, including
The step of each component of the cosmetics is mixed.
Specifically, the preparation method of the skin whitening, moisturizing frost the following steps are included:
1, emulsion pot, stirring is added in grease, emulsifier, part preservative, aromatic, part thickener, antioxidant
And it is heated to 80-85 DEG C, it is allowed to sufficiently dissolve；
2, water phase is added in Jiang Shui, part moisturizer, chelating agent, remaining thickener, pH adjusting agent, partial skin conditioner
Pot stirs and is heated to 80-85 DEG C, is allowed to sufficiently dissolve；
3, the aqueous phase substance in water phase pot is slowly extracted into emulsion pot, stirring, homogeneous, vacuum emulsification keep emulsification pot temperature
Degree is 80-85 DEG C；
4, it is cooled to 60-65 DEG C, remaining moisturizer is added and partial skin conditioner phase homogeneous stirs evenly；
5, it is cooled to 40-45 DEG C, skin-lightening cosmetic additive, remaining preservative and remaining skin conditioning agent is added and stirs
It mixes uniformly；
6, it is cooled to 35-40 DEG C, discharging stands 12-48 hours；
7, it after the assay was approved, dispenses, pack, then examine, warehousing finished products.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
It can be with conventional products that are commercially available.
Comparative example 1-5
Take ginseng extract as skin-lightening cosmetic additive.It is 6.8 by the pH that ginseng extract is dissolved in 5 groups of different volumes
Phosphate buffer in, obtain the test solution of 5 groups of various concentrations.Wherein, logarithm mass concentration such as the following table 2 of ginseng extract
It is shown.
Comparative example 6-10
Take mint extract as skin-lightening cosmetic additive.Mint extract is dissolved in 5 groups and comparative example 1-5 corresponding body
In the phosphate buffer that long-pending pH is 6.8, the test solution of 5 groups with comparative example 1-5 corresponding concentration is obtained.Wherein, peppermint is extracted
The logarithm mass concentration of object is as shown in table 2 below.
Embodiment 1-7
Take ginseng extract and mint extract as skin-lightening cosmetic additive.By ginseng extract and mint extract
2:1 in mass ratio (embodiment 1), 1:1 (embodiment 2), 1:2 (embodiment 3), 15:85 (embodiment 4), 5:95 (embodiment 5),
After 2:98 (embodiment 6), 7:69 (embodiment 7) mixing, skin-lightening cosmetic additive is obtained.By embodiment 1-5,7 whitening
Cosmetic additive is dissolved in respectively in the phosphate buffer that the pH of 5 groups and comparative example 1-5 corresponding volume is 6.8, by the beauty of embodiment 6
White cosmetic additive agent is dissolved in the pH of 4 groups and comparative example 1-4 corresponding volume respectively in 6.8 phosphate buffer.Embodiment 1-7
The test solution of 5 groups available (or 4 groups) and comparative example 1-5 (or comparative example 1-4) corresponding concentration.Wherein, whitening is made up
In product additive, the content (quality %) of ginseng extract and mint extract as shown in table 1 below, skin-lightening cosmetic additive
Logarithm mass concentration is as shown in table 3 below.
Table 1
Testing in vitro
Tyrosinase activity is measured with being catalyzed the tyrosinase vigor of L-3,4 dihydroxyphenylalanine generation DOPA quinone.Specifically:
1 test tube is taken, is added substrate L-3,4 dihydroxyphenylalanine solution 0.4mL (1.0mg/mL), and adds the phosphate buffer that pH is 6.8
After 2.4mL, 30 DEG C of water-bath heat preservation 10min, the amount that tyrosinase is then added is 0.2mL (250U/mL), obtains reaction solution 1.
1 test tube is taken, the amount that tyrosinase is added is 0.2mL (250U/mL), and adds the phosphate buffer that pH is 6.8
2.8mL obtains reaction solution 2.
Substrate L-3,4 dihydroxyphenylalanine solution 0.4mL (1.0mg/mL) is added in 44 test tubes respectively, is then respectively adding 2.4mL's
The test solution of comparative example 1-10 and embodiment 1-7, after 30 DEG C of water-baths keep the temperature 10min, the amount that tyrosinase is then added is
0.2mL (250U/mL), obtains reaction solution 3.
The test solution of the comparative example 1-10 and embodiment 1-7 of 2.4mL is added in 44 test tubes respectively, and adds pH and is
After 6.8 phosphate buffer 0.4mL, 30 DEG C of water-bath heat preservation 10min, the amount that tyrosinase is then added is 0.2mL (250U/
ML), reaction solution 4 is obtained.
L-3,4 dihydroxyphenylalanine is converted red product DOPA quinone by enzymatic reaction, there is absorption maximum at 475nm.Reading is opened from mixing
Absorbance A when beginning 1min at 475nm475, the speed of enzymatic reaction A per minute475Value added indicate.It measures above-mentioned
Absorbance A of the reaction solution when reaction starts 1min at 475nm, and the inhibition to tyrosinase activity is calculated as follows
Rate.Wherein, the mass concentration of the skin-lightening cosmetic additive in table is end of the skin-lightening cosmetic additive in test system
Mass concentration.
Inhibiting rate=[1- (A3-A4)/(A1-A2)] × 100%
In formula: A1Not add skin-lightening cosmetic additive, only containing substrate when absorbance；
A2Absorbance not add skin-lightening cosmetic additive, and when not adding substrate；
A3To contain skin-lightening cosmetic additive and absorbance when substrate；
A4Absorbance for containing skin-lightening cosmetic additive, and when not adding substrate.
It calculates separately to obtain ginseng extract (comparative example 1-5) and mint extract (comparative example 6-10) is respective to junket ammonia
The inhibiting rate of phytase activity.And logarithm mass concentration-tyrosinase inhibition rate relational graph is combined, conversion acquires ginseng extract
Inhibiting rate corresponding mass concentration (IC when being 50%50A) and mint extract inhibiting rate be 50% when corresponding quality it is dense
Spend (IC50B), the results are shown in Table 2.
Table 2
Then the inhibiting rate of the tyrosinase of the skin-lightening cosmetic additive of embodiment 1-7 is measured.And combine logarithm quality
Concentration-tyrosinase inhibition rate relational graph, conversion acquires ginseng extract and mint extract compound action generates equivalent suppression
When rate (50%) processed, the mass concentration (IC of ginseng extract50a), ginseng extract and the generation of mint extract compound action etc.
When imitating inhibiting rate (50%), the mass concentration ((IC of mint extract50b), the results are shown in Table 3.
The effect of the compound action of ginseng extract and mint extract can be evaluated with interaction coefficient γ, tool
The results are shown in Table 3 for body.
γ=IC50a/IC50A+IC50b/IC50B
Wherein, IC50AThe inhibiting rate for indicating ginseng extract corresponding mass concentration when being 50%；
IC50BThe inhibiting rate for indicating mint extract corresponding mass concentration when being 50%；
IC50aWhen indicating that ginseng extract and mint extract compound action generate equivalent inhibiting rate (50%), ginseng is extracted
The mass concentration of object；
IC50bWhen indicating that ginseng extract and mint extract compound action generate equivalent inhibiting rate (50%), peppermint is extracted
The mass concentration of object；
Wherein, γ=1 indicates that ginseng extract and mint extract show as simple additive effect；γ < 1 mentions for ginseng
Object and mint extract is taken to show as synergistic effect, γ value is smaller, and synergistic effect is stronger；γ > 1 is ginseng extract and peppermint
Extract shows as antagonistic effect, and γ value is bigger, and antagonistic effect is bigger.
Table 3
As can be seen from Table 3, the interaction coefficient in skin-lightening cosmetic additive of the invention is less than 1, and it is mutually
Function coefficient value can be below 0.6, it might even be possible to 0.5 hereinafter, therefore ginseng extract and mint extract can show
For excellent synergistic effect.
Application Example 1-8
According to content (the quality percentage of each component in the skin whitening, moisturizing frost of the Application Example 1-8 in the following table 4-5 formula
Than), and skin whitening, moisturizing frost is prepared according to following production craft steps.Production craft step is as follows:
1, emulsion pot is added in A phase raw material, is stirred and heated to 80-85 DEG C, is allowed to sufficiently dissolve；
2, B is added to water phase pot, stirs and is heated to 80-85 DEG C, be allowed to sufficiently dissolve；
3, B phase pot inner aqueous phase substance is slowly extracted into emulsion pot, stirring, homogeneous, vacuum emulsification, holding emulsification pot temperature is
80-85℃；
4,60 DEG C are cooled to, C phase homogeneous is added and stirs evenly；
5,42 DEG C are cooled to, D phase is added and stirs evenly；
6,37 DEG C are cooled to, discharging stands 24 hours；
7, it after the assay was approved, dispenses, pack, then examine, warehousing finished products.
Note: A phase, B phase, C phase, D phase in technique be respectively,
A phase: ring five dimethyl silicone polymer, Parleam, caprylic/capric triglyceride, ethylhexyl palmitate,
The compound of the pure and mild cetearyl glucoside of cetearyl alcohol, Dimethicone/Vinyl Dimethicone crosslinking
The smooth sesquialter of compound, dimethyl silicone polymer, sorb of polymer, docosyl alcohol, PEG-100 stearate and stearine
The compound of oleate and isosteareth -20, tocopherol acetate, methyl hydroxybenzoate, Nipasol, Butylated Hydroxytoluene, essence；
B phase: deionized water, glycerol, butanediol, propylene glycol, dipropylene glycol, EDTA-2Na, xanthan gum, carbomer, hydrogen-oxygen
Change potassium, panthenol, Colloidal oatmeal, Sodium Hyaluronate；
C phase: glycerine polyacrylate, Cer NS；
D phase: sea lettuce extract, ginseng extract, mint extract, Phenoxyethanol, beta glucan.
Ginseng extract used in formula, mint extract are skin-lightening cosmetic additive；
Ring five dimethyl silicone polymer, Parleam, caprylic/capric triglyceride, ethylhexyl palmitate, poly- two
Methylsiloxane is grease；
The compound of the pure and mild cetearyl glucoside of cetearyl alcohol, PEG-100 stearate and stearine
The compound of compound, sorbitan sesquioleate and isosteareth -20 is emulsifier；
Tocopherol acetate, Butylated Hydroxytoluene are antioxidant；
Glycerol, butanediol, propylene glycol, dipropylene glycol, panthenol, Sodium Hyaluronate, glycerine polyacrylate are moisturizer；
Colloidal oatmeal, sea lettuce extract, Cer NS, beta glucan are skin conditioning agent；
EDTA-2Na is chelating agent；
Potassium hydroxide is pH adjusting agent；
Xanthan gum, carbomer, Dimethicone/Vinyl Dimethicone cross-linked polymer, docosyl alcohol are
Thickener；
Methyl hydroxybenzoate, Nipasol, Phenoxyethanol are preservative.
Essence is aromatic.
In the present invention, the compound of the pure and mild cetearyl glucoside of cetearyl alcohol, manufacturer: match BIC Corp's board
Number: MONTANOV 68；
The compound of PEG-100 stearate and stearine, manufacturer: the standing grain major company trade mark: ARLACEL
165；
The compound of sorbitan sesquioleate and isosteareth -20, Ba Rui company, the manufacturer trade mark:
BAREMULTMML；
Ginseng extract, manufacturer: Zhan Hong Biotechnology Co., Ltd, Quzhou City；
Mint extract, manufacturer: Zhan Hong Biotechnology Co., Ltd, Quzhou City.
Comparison study example 1-2
According to the content (mass percent) of each component in the moisturiser of the Comparison study example 1-2 in the following table 5 formula, and press
According to method identical with Application Example 1-8, moisturiser is prepared.
Table 4
Table 5
White-skinned face function test
The test method of dermal melanin change rate: by measure specific wavelength illumination on human skin after reflection
Measure the content to determine melanin in skin.It is respectively tri- kinds of 568nm, 660nm and 880nm that the transmitter of probe, which issues wavelength,
The light of wavelength is radiated at skin surface, and recipient measures the light of skin reflex, and measures the amount for the light being absorbed by the skin, so as to
To obtain the change rate of dermal melanin.
The test of dermal melanin change rate is tested using the detector for pigment of CK company, Germany, wherein skin is black
The test probe MX 18 of pigment is made of light source emitter and receiver, to the pressure of skin when having spring separately to keep detection
It is constant.The measurement range of probe is 0-999, and measurement numerical value is higher, it may be said that the content of melanin is higher in bright skin.
Number of subjects is 33 people, and the test period is 4 weeks, test choose Application Example 1-8 skin whitening, moisturizing it is white and
The moisturiser of Comparison study example 1-2, is applied to the different zones of inner forearm sooner or later daily, respectively before measurement experiment (Day1) and
Using volume reflection of the skin in the tested region of (Day28) at 28 days after the illumination of specific wavelength to determine melanin in skin
Content, and then characterize the change rate of melanin, the result of the change rate of specific melanin is as shown in Figure 5.
As seen from Figure 5, the change rate of the melanin of the Application Example 1-8 of the application is larger, i.e. melanin content
It reduces, therefore, uses ginseng extract and mint extract as skin-lightening cosmetic additive, it being capable of whitening effect skin.
In addition, in the Application Example 6-8 of the application, since the content of ginseng extract is higher, melanin content drop
It is low less.
In the Comparison study example 1-2 of the application, make in single use ginseng extract or single use mint extract
When for skin-lightening cosmetic additive, melanin content change rate is small, and melanin content reduces few, and whitening effect is poor.
The above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be to the present invention
Embodiment restriction.For those of ordinary skill in the art, it can also make on the basis of the above description
Other various forms of variations or variation.There is no necessity and possibility to exhaust all the enbodiments.It is all of the invention
Made any modifications, equivalent replacements, and improvements etc., should be included in the protection of the claims in the present invention within spirit and principle
Within the scope of.
Claims (10)
1. a kind of skin whitening, moisturizing frost, which is characterized in that including skin-lightening cosmetic additive, with the gross mass of the skin whitening, moisturizing frost
Meter, the additional amount of the skin-lightening cosmetic additive are 0.01-15%；The skin-lightening cosmetic additive includes ginseng extract
And mint extract.
2. skin whitening, moisturizing frost according to claim 1, which is characterized in that the skin whitening, moisturizing frost further includes moisturizer, increases
Thick dose, pH adjusting agent, grease, emulsifier, skin conditioning agent, antioxidant and chelating agent；Wherein, with the skin whitening, moisturizing frost
Gross mass meter, the additional amount of the moisturizer are 0.01-20%；The additional amount of the thickener is 0.02-5%；The pH tune
The additional amount for saving agent is 0.01-1%；The additional amount of the grease is 10-30%；The additional amount of the emulsifier is 0.01-
5%；The additional amount of the skin conditioning agent is 0-10%；The additional amount of the antioxidant is 0.01-2%；The chelating agent
Additional amount be 0.01-1%.
3. skin whitening, moisturizing according to claim 2 frost, which is characterized in that the moisturizer includes propylene glycol, butanediol, general
The combination of one or more of alcohol, dipropylene glycol, glycerol, glycerine polyacrylate, Sodium Hyaluronate, trehalose；With/
Or
The grease includes that isopropyl myristate, dimethyl silicone polymer, ring five dimethyl silicone polymer, caprylic/capric are sweet
Oily three esters, oleyl alcohol eruciate, Parleam, Butyrospermum parkii fruit rouge, ethylhexyl palmitate, Nexbase 2004, hexamethylene silicon
Oxygen alkane, C20-24 alkyl dimethicone, C13-14 isoparaffin, C12-15 alcohol benzoic ether, oil with hydrogenated soybean, plant
The combination of one or more of sterols, olive oil unsaponifiable matter.
4. skin whitening, moisturizing frost according to claim 2 or 3, which is characterized in that the emulsifier includes that cetearyl alcohol is pure and mild
The smooth sesquialter oleic acid of the compound of cetearyl glucoside, the compound of PEG-100 stearate and stearine, sorb
The compound of ester and isosteareth -20, PEG-10 campesterol, laureth -7, -3 methyl two of polyglycereol
Stearate, PEG/PPG-10/1 dimethyl silicone polymer, polyglyceryl-3 diisostearate, stearine, stearyl alcohol
One or more of the combination of one or more of polyethers -20, ceteth -20, polysorbate -60
Combination；And/or
The pH adjusting agent includes aminomethyl propanol, arginine, citric acid, sodium citrate, sodium hydroxide, one in potassium hydroxide
Kind or two or more combinations.
5. according to claim 2-4 described in any item skin whitening, moisturizings frost, which is characterized in that the thickener include carbomer,
Xanthan gum, Dimethicone/Vinyl Dimethicone cross-linked polymer, docosyl alcohol, polyacrylamide, acryloyl
One or both of dimethyltaurine ammonium/VP copolymer, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers
Above combination；And/or
The antioxidant include vitamin E, tocopherol acetate, Butylated Hydroxytoluene, lycopene, in ascorbic acid ethylether
A combination of one or more.
6. according to the described in any item skin whitening, moisturizing frosts of claim 2-5, which is characterized in that the skin conditioning agent includes deep-sea
Two section shepherd's purse seed oil, brown alga extract, palmitoyl oligopeptide, magnesium aminosuccinate, Cer NS, bulk kelp extract, allantoin, hydrolysis
Collagen, sea lettuce extract, Colloidal oatmeal, beta glucan, heartsease extract, PEG-10 campesterol, chlorella
The combination of one or more of tunning；And/or
The chelating agent includes EDTA-2Na and/or EDTA-4Na.
7. skin whitening, moisturizing frost according to claim 1-6, which is characterized in that with the skin-lightening cosmetic additive
Gross mass meter, the additional amount of the ginseng extract is 0.1-80%, and the additional amount of the mint extract is 20-
99.9%.
8. skin whitening, moisturizing frost according to claim 7, which is characterized in that the ginseng extract and the mint extract
Mass ratio be 1:0.4~75, preferably 1:1~70, more preferably 1:1.5~65, further preferably 1:2~60, more into
One step is preferably 1:2.5~57, much further preferably from 1:3~55.
9. a kind of preparation method of skin whitening, moisturizing frost according to claim 1-8, which is characterized in that including by institute
The step of stating each component mixing of skin whitening, moisturizing frost.
10. a kind of skin-lightening cosmetic additive, which is characterized in that including ginseng extract and mint extract, with the whitening
The gross mass meter of cosmetic additive agent, the additional amount of the ginseng extract are 0.1-80%, the addition of the mint extract
Amount is 20-99.9%；Preferably,
The mass ratio of the ginseng extract and the mint extract is 1:0.4~75, preferably 1:1~70, more preferably
1:1.5~65, further preferably 1:2~60 are still more preferably 1:2.5~57, much further preferably from 1:3~55.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846750A (en) * | 2019-03-29 | 2019-06-07 | 湖南御家化妆品制造有限公司 | A kind of cosmetics of composition and its reparation skin of preparation |
| CN111012732A (en) * | 2020-01-10 | 2020-04-17 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening cream |
| CN111110624A (en) * | 2020-01-10 | 2020-05-08 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening composition |
| CN113233976A (en) * | 2021-05-08 | 2021-08-10 | 广州萃普生物科技有限公司 | Gallic acid and aminoacetic acid eutectic and whitening cream containing eutectic |
| CN113925788A (en) * | 2021-09-03 | 2022-01-14 | 太和康美(北京)中医研究院有限公司 | Sleep mask containing phytosterol and phytosterol ester and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070114953A (en) * | 2006-05-30 | 2007-12-05 | 김수산 | Composition for improving troublesome skin comprising herb extract |
| CN105581952A (en) * | 2014-10-22 | 2016-05-18 | 曹涛 | Food-grade anti-wrinkle anti-aging essence eye cream |
| CN106236687A (en) * | 2016-08-26 | 2016-12-21 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant facial cream of chlorophyll and preparation method thereof |
| CN107811926A (en) * | 2017-09-30 | 2018-03-20 | 朱耀灯 | A kind of oil control and acne removal gel |
| CN108403503A (en) * | 2018-04-25 | 2018-08-17 | 琦雅日化(上海)有限公司 | One kind is containing face mask of traditional Chinese medicine and preparation method thereof |
| CN108685755A (en) * | 2018-08-07 | 2018-10-23 | 谷良文 | VE eyes conserve cream |
| CN108815044A (en) * | 2018-08-16 | 2018-11-16 | 常州市西林门窗工程有限公司 | A kind of skin protection bath cream |
-
2018
- 2018-12-26 CN CN201811603394.4A patent/CN109431908B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070114953A (en) * | 2006-05-30 | 2007-12-05 | 김수산 | Composition for improving troublesome skin comprising herb extract |
| CN105581952A (en) * | 2014-10-22 | 2016-05-18 | 曹涛 | Food-grade anti-wrinkle anti-aging essence eye cream |
| CN106236687A (en) * | 2016-08-26 | 2016-12-21 | 广东科玮生物技术股份有限公司 | A kind of crease-resistant facial cream of chlorophyll and preparation method thereof |
| CN107811926A (en) * | 2017-09-30 | 2018-03-20 | 朱耀灯 | A kind of oil control and acne removal gel |
| CN108403503A (en) * | 2018-04-25 | 2018-08-17 | 琦雅日化(上海)有限公司 | One kind is containing face mask of traditional Chinese medicine and preparation method thereof |
| CN108685755A (en) * | 2018-08-07 | 2018-10-23 | 谷良文 | VE eyes conserve cream |
| CN108815044A (en) * | 2018-08-16 | 2018-11-16 | 常州市西林门窗工程有限公司 | A kind of skin protection bath cream |
Non-Patent Citations (1)
| Title |
|---|
| 李树莱: "功能性化妆品的分类与现状", 《医学美学美容》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846750A (en) * | 2019-03-29 | 2019-06-07 | 湖南御家化妆品制造有限公司 | A kind of cosmetics of composition and its reparation skin of preparation |
| CN111012732A (en) * | 2020-01-10 | 2020-04-17 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening cream |
| CN111110624A (en) * | 2020-01-10 | 2020-05-08 | 佐登妮丝（广州）美容化妆品有限公司 | Whitening composition |
| CN113233976A (en) * | 2021-05-08 | 2021-08-10 | 广州萃普生物科技有限公司 | Gallic acid and aminoacetic acid eutectic and whitening cream containing eutectic |
| CN113925788A (en) * | 2021-09-03 | 2022-01-14 | 太和康美(北京)中医研究院有限公司 | Sleep mask containing phytosterol and phytosterol ester and preparation method thereof |
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Effective date of registration: 20220818 Address after: No.23 Xianke Er Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province 510800 Patentee after: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee after: GUANGDONG DANZ GROUP Co.,Ltd. Address before: No.23, Xianke 2nd Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province, 510890 Patentee before: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee before: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT Patentee before: GUANGDONG DANZ GROUP Co.,Ltd. |