CN109431554A - A kind of interventional medicine I-shaped closer of vascular puncture mouth and preparation method thereof - Google Patents
A kind of interventional medicine I-shaped closer of vascular puncture mouth and preparation method thereof Download PDFInfo
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- CN109431554A CN109431554A CN201810959536.4A CN201810959536A CN109431554A CN 109431554 A CN109431554 A CN 109431554A CN 201810959536 A CN201810959536 A CN 201810959536A CN 109431554 A CN109431554 A CN 109431554A
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- vascular
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- 230000002792 vascular Effects 0.000 title claims abstract description 50
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 241000463219 Epitheca Species 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 210000004204 blood vessel Anatomy 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 4
- 238000001085 differential centrifugation Methods 0.000 claims description 3
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical group C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 3
- 238000013152 interventional procedure Methods 0.000 claims description 3
- 238000011017 operating method Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 2
- 238000013459 approach Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 abstract description 5
- 229920002521 macromolecule Polymers 0.000 abstract description 2
- 230000007334 memory performance Effects 0.000 abstract 1
- 230000000474 nursing effect Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 238000005266 casting Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000009434 installation Methods 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000009087 False Aneurysm Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010048975 Vascular pseudoaneurysm Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 206010018852 Haematoma Diseases 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 206010046542 Urinary hesitation Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000000968 medical method and process Methods 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
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- 238000004088 simulation Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C39/00—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor
- B29C39/02—Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressure; Apparatus therefor for making articles of definite length, i.e. discrete articles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00654—Type of implements entirely comprised between the two sides of the opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
Abstract
The invention discloses a kind of interventional medicine I-shaped closers of vascular puncture mouth and preparation method thereof, the closer is dies such as figure (1), by closer 1., in closer epitheca 2. 4., joystick control 3. 5., inner core tube 6. 7., 8. connecting line forms, it is the closer that " I " fonts are fabricated to by biodegradable macromolecule polyalcohol, the interior outward buckle disk folder of high resiliency memory performance closes intravascular outer wall, it is enough degradable in 4-6 weeks, be conducive to the regeneration and reparation of vascular wall.This I-shaped vascular puncture mouth closer is easy to operate, can effectively close vascular puncture mouth, it can effectively reduce postoperative risk, alleviates the pain of patient and the intensity of medical treatment and nursing.
Description
Technical field
The present invention relates to a kind of interventional medicine I-shaped closers of vascular puncture mouth and preparation method thereof, and in particular to
It is the closer and preparation method thereof for closing vascular puncture mouth after the minimally invasive intervention of one kind is performed the operation, belongs to medical instruments field,
Background technique
Intravascular Minimally Interventional Therapy technology is widely used in clinic in recent years, is based on the tracer in medical imaging device
Under look-out, interventional medical device is sent to human body vitals and position, such as: heart, brain, kidney, digestive system and reproduction
System carries out the new technology and method of diagnosing and treating, there is small wound, therapeutic process and hospital stays significantly to shorten, payment for medical care
The advantages of with relative moderate.Traditional medical method is substituted using minimal invasive techniques and carries out Clinics and Practices operation, is had become at present
Medical domain treats the most widely used medical procedure of full spectrum of threats human health disease, micro- at present in all operations
Ratio shared by wound interventional therapy alreadys exceed 85%, and the minimally invasive interventional medicine of intravascular has evolved into modern medicine in recent years
One of the three big diagnoses and treatment technologies arranged side by side with department of medicine and surgery, and a clinical speciality with fastest developing speed in recent years, are doctors
Treat the hot spot of boundary's development.
Currently, how the puncture orifice on quick-make vascular wall is still one not yet in intravascular intra-operative procedures
The problem solved very well, also because needing to carry out either manual pressure first and reinforce wrapping delay operation time, art at present
Row is extracted again after being formed to the constraint of patient and puzzlement, postoperative false aneurysm afterwards, need to stop for a long time after anticoagulation
Being limited in bed for a long time with press sealed puncture orifice, reservation leads to urinary hesitancy and in the presence of because closing undesirable danger complications.
Document report in the world uses the vascular complication incidence of conventional vascular hemostasis by compression for 5-9% after femoral artery puncture.State
Interior document report, the occurrence rate of hematoma 20.9%, false aneurysm incidence are 14.55%, bleeding event 7.27%.Such as
This high not disease, so that how fast and vascular puncture mouth becomes minimally invasive menses anxious to be resolved after effectively turning off blood vessel intervention
The problem of pipe intervention apparatus research and development and production.Clinically, domestic at present mainly by extracting earlier either manual pressure after catheter sheath, then
Based on the method for pressure dressing, constraint and limitation patient activity.Thus it is subcutaneously huge to be likely to occur postoperative site of puncture for some patientss
The dangerous complication such as big hemotoncus, the big bleeding of puncture orifice.So do not only result in intravascular intervention operation take a long time, patient it is postoperative
Very uncomfortable and puzzlement and worry there is postoperative complications.
External and Some Domestic large hospital uses the intervention site of puncture haemostat (commodity of Terumo company, Japan production
Name: TR-Band)；StarClose the and Proglide blood vessel of U.S. StJude company Angio-Seal and Abott company, the U.S.
Puncture orifice closer.These instruments largely shorten the time of After Endovascular Interventional Procedures, alleviate the discomfort of patient.
But all jointly there is: operating process is excessively cumbersome, price is excessively high, close effect it is different the deficiencies of.And due to import
Closer is at high price, and most domestic hospital have to select using either manual pressure, then pressure dressing limit in most basic art
It makes movable mode and handles vascular puncture mouth.
Summary of the invention
The purpose of the present invention is create a kind of pass that can be quickly and effectively closed minimally invasive intervention post-surgical vascular puncture orifice
Device is closed, vascular puncture mouth closer solves clinical problem from following several respects:
Outspoken fast closer action principle innovation-" I " fonts closer of interventional medicine vascular puncture, inside and outside vascular wall
" I " fonts clips are closed:
" I " fonts have the advantages that the deadend of puncture orifice: first, without similar state in mode of operation
Outer similar closer need to check blood back and many and diverse operating procedure, can complete at once, reach simple and easy to do feature.Second,
The closing of " work " word structure, can reach the effect of tight closure due to linking closely up and down.
Innovation -- the selection of novel internal degradable material of the outspoken fast closer making material of interventional medicine vascular puncture:
The present invention uses biodegradable material for the first time -- and long-chain, which is fitted into, integrates one made by high molecular material-PLLA-TMC
The closer of body, the closer complete that whole natural degradations are conducive to vascular wall and are regenerated in three months after closure vascular wall
And the reparation of vascular integrity.Such high molecular material binding soln casting is not only easy to 3 dimension spaces of molding making complexity
Configuration keeps manufacturing process fast and convenient, and its physical characteristic for combining elasticity and being rigidly integrated is extremely easy to be fabricated to
Conducive to medical instrument used in Minimally Interventional Therapy.
The completely new accurate quick shaping process of the outspoken fast closer of interventional medicine vascular puncture-satellite centrifugal process casting essence
Close molding: high molecular material is usually gone in solution dissolution, mixing and scatter operation using stirring and dissolving and negative-pressure ward
Bubble technology, such method not only low efficiency, Yi Liucun bubble, and quality is difficult to be guaranteed.The present invention uses satellite differential
Centrifugal process has the function of Quick uniform mixing and drives away bubble in solution simultaneously, and dissolution is abundant and defoams and evenly dispersed effect
It is prominent, it ensure that the quality of production closer.
After the closer is placed to Endovascular by short sheath, the application method of the closer can be summarized as follows: one is moved back
One drawing is further moved back.
One moves back: exiting closer outer tube (3. manipulation epitheca joystick control is completed) makes the closer lower wall of bottom in lumen of vessels
It inside flicks discoid.
One draws: pulling, makes in the disc-shaped opening of Endovascular outward together together with short sheath and connecting line and closer
Lower wall is adjacent to vascular puncture mouth inner wall.
One moves back: exit closer inner tube (manipulation epitheca joystick control 5. complete), turn off on device disk can appliance for releasing single in blood
It is flicked at pipe puncture orifice outer wall, forms the external disk of covering vascular puncture mouth.
Technical indicator
The scope of application: it can be used for the quick-make of caused vascular wall puncture orifice after the short sheath of 5F to 14F punctures.
It closes effect: realizing vessel sealing immediately.
Operation difficulty: (the external complicated similar products of comparison) are reduced to insertion, push, the easy operating process of outer drawing.
Detailed description of the invention
Fig. 1 is the short sheath structural schematic diagram of the present invention；
Fig. 2 is " I " fonts closer structural schematic diagram of the present invention；
Fig. 3 is that schematic diagram after sheath is extracted in present invention push pipe integrated installation portion；
Fig. 4 is that short sheath pulls out schematic diagram after sheath is extracted in present invention push pipe integrated installation portion；
Fig. 5 is the I-shaped short sheath of the present invention and guy structure schematic diagram thereon；
Fig. 6 is inventive die production schematic diagram；
Fig. 7 is closer production process of the present invention and step schematic diagram；
Fig. 8 is " I " fonts closer of the present invention and sphygmomanometer attachment structure schematic diagram.
Specific embodiment
Raw material selection: biodegradable material -- long-chain is fitted into high molecular material-PLLA-TMC, can be short for invention selection
It is degraded in time by body absorption, and vascular wall puncture orifice will be slowly replaced by blood vessel hyperplasia tissue, reach vascular wall reparation
It rebuilds.
As shown in figures 1-8.
Embodiment:
Production process and step 1, " I " fonts closer modelling, satellite differential centrifugation, moulding by casting.Macromolecule
Material usually solution dissolution, mixing and scatter operation in using stirring and dissolving and negative-pressure ward de-soak technology, it is such
Method not only low efficiency, Yi Liucun bubble, and quality is difficult to be guaranteed.The present invention is had quick using satellite differential centrifugation
The effect of bubble in solution is uniformly mixed and driven away simultaneously, abundant and defoaming and evenly dispersed effect protrusion is dissolved, ensure that system
Make the quality of closer.
2, sheath, push pipe production.
3, " I " fonts closer, sheath, push pipe integrated installation, sealed package.
After being punctured short sheath merging vascular puncture mouth, implemented by easy following steps:
1, push pipe button is pushed, closer is pushed into Endovascular；
2, it extracts outward and punctures short sheath, can experience at this time and close upper valve and dashed forward vascular puncture mouth, closer rests on blood
By tube wall.
3, continue to extract short sheath, cut and expose in extracutaneous connecting line, shutoff operation is completed.
4, after the completion of closing, closer is located at the inside and outside of vascular wall, realizes quick-make vascular puncture mouth.
External simulation test
1, it is carried out in vitro test closed duct system as shown in figure (8).In the system, the silicone tube of 6mm internal diameter is rushed
Full water, silicone tube distal end are closed, and the other end then connects the plastic infusion bottle to be pressurizeed by sphygmomanometer.Sphygmomanometer pressurizes and stablizes
130mm mercury column.Therefore, hydraulic in silicone tube is also all 130mm mercury column.
2, in vascular puncture interventional procedure, intravascular fluid pressure and vascular intervention operation proceed to modeling
Short sheath is extracted, the stage of vascular wall puncture orifice is closed.Test result: I-shaped closer can close simple and effectively blood vessel and wear
Mouth is pierced, blood outflow is stopped.
Actual effect of the invention: directly blocking and sealing blood vessels wall opening have reached best closing vascular puncture mouth
Effect, biodegradable material can deadend of the slow-absorbing completion to vascular wall puncture orifice.The present invention not only greatly mitigates
Medical worker be closed the workload consumed when vascular puncture mouth, it is simple and effective be closed vascular puncture mouth, and be greatly improved through
The postoperative comfort level of intravascular minimally invasive intervention, make patient can out-of-bed activity quickly, be conducive to the healing and reparation of puncture orifice.
Claims (5)
1. a kind of interventional medicine I-shaped closer of vascular puncture mouth, it is characterised in that the vascular puncture mouth closer told is
Bio-degradable material casts and becomes I-shaped structure, and quick closedown device is using " I " fonts clamp-buckle at puncture orifice position
Blood vessel and outer wall on, formed be close to puncture orifice and to puncture orifice realize cover type inside and outside precision clamping close, see figure (1)；Figure
(2) the differently curved direction of closer upper lower burrs 1. is paid attention to load spare closer in；2. being closer epitheca, controllably
Closer lower wall processed；3. moving up control handwheel for epitheca, when the disk drives epitheca to move up, the lower wall meeting appliance for releasing single of closer is at disk
Shape is shown in (3)；4. can control the upper disk of closer for sheath in closer；5. joystick control is moved up for interior sheath, when the disk drives interior sheath
When moving up, on closer disk can appliance for releasing single it is discoid, see (4)；7. the company of closer can be passed through among the pipe 6. being inner core tube
8., the bottom of the inner core approaches the rear of disk on closer for wiring.
2. a kind of interventional medicine according to claim 1 I-shaped closer of vascular puncture mouth, it is characterised in that told
Closer be vertical section overstriking I-shaped structure, in closed configuration, under the " I " fonts in 3 or 4 valve lobulateds
Disk not only entered Endovascular convenient for loading and being conducive to push through push sheath, but also wore as endovascular jacking part closure blood vessel
Pierce mouth；And the structure above I-shaped becomes the fixation device outside vascular wall, to achieve the purpose that be closed puncture orifice.
3. one kind is with a kind of interventional medicine I-shaped closer of vascular puncture mouth described in claim 1, it is characterised in that: system
The raw material for making the I-shaped closer of vascular puncture mouth is to be fitted into high molecular material-PLLA-TMC institute group by biodegradable long-chain
At the good biocompatibility of this material can degrade in vivo, and physical strength is high and elastic recovery properties are good.
4. a kind of operating method with vascular puncture mouth closer described in claim 1, it is characterised in that: the present invention is used and defended
Star differential centrifugation has the function of Quick uniform mixing and drives away bubble in solution simultaneously, dissolves sufficiently and defoams and uniformly divide
The effect of dissipating protrudes, and ensure that the quality of production quick closedown device.
5. a kind of operating method with vascular puncture mouth closer described in claim 1, it is characterised in that: this method include with
Lower step: 1) after interventional procedure be nearly completed after, which is placed in Endovascular (this closer pipe range by short sheath
More than about 3-5 centimetres of sheath short for model), so that the front end of this closer is projected into Endovascular from short sheath front end；2) it moves up
3., when the disk drives epitheca to move up, the lower wall meeting appliance for releasing single of closer is discoid for epitheca control handwheel, sees (3)；3) connect short sheath,
Connecting line and closer are pulled outward together, make to be adjacent in vascular puncture mouth in the lower wall of the disc-shaped opening of Endovascular
5. wall then moves up interior sheath joystick control, when sheath moves up in the disk drives, on closer disk can appliance for releasing single in vascular puncture mouth
It is flicked at outer wall, forms the external disk of covering vascular puncture mouth, so far, closer forms " work " shape inside and outside vascular puncture mouth
Folder closes, and closer is withdrawn from vitro together together with short sheath, end operation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810959536.4A CN109431554A (en) | 2018-08-22 | 2018-08-22 | A kind of interventional medicine I-shaped closer of vascular puncture mouth and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810959536.4A CN109431554A (en) | 2018-08-22 | 2018-08-22 | A kind of interventional medicine I-shaped closer of vascular puncture mouth and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109431554A true CN109431554A (en) | 2019-03-08 |
Family
ID=65530154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810959536.4A Pending CN109431554A (en) | 2018-08-22 | 2018-08-22 | A kind of interventional medicine I-shaped closer of vascular puncture mouth and preparation method thereof |
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| Country | Link |
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| CN (1) | CN109431554A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113940724A (en) * | 2021-12-01 | 2022-01-18 | 厦门大学附属中山医院 | False aneurysm sealer |
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|---|---|---|---|---|
| US20070191884A1 (en) * | 2005-10-19 | 2007-08-16 | Pulsar Vascular, Inc. | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
| US20140296907A1 (en) * | 2004-08-27 | 2014-10-02 | Accessclosure, Inc. | Apparatus and Methods for Facilitating Hemostasis within a Vascular Puncture |
| CN105496480A (en) * | 2016-01-21 | 2016-04-20 | 深圳麦普奇医疗科技有限公司 | Blood vessel puncture site closer and operation method thereof |
| CN107789023A (en) * | 2016-08-30 | 2018-03-13 | 周佳蓉 | Blood vessel puncture sealing device |
| CN107802311A (en) * | 2017-11-20 | 2018-03-16 | 乐普（北京）医疗器械股份有限公司 | A kind of Wholly-degradable vessel sealing structure |
-
2018
- 2018-08-22 CN CN201810959536.4A patent/CN109431554A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140296907A1 (en) * | 2004-08-27 | 2014-10-02 | Accessclosure, Inc. | Apparatus and Methods for Facilitating Hemostasis within a Vascular Puncture |
| US20070191884A1 (en) * | 2005-10-19 | 2007-08-16 | Pulsar Vascular, Inc. | Methods and systems for endovascularly clipping and repairing lumen and tissue defects |
| CN105496480A (en) * | 2016-01-21 | 2016-04-20 | 深圳麦普奇医疗科技有限公司 | Blood vessel puncture site closer and operation method thereof |
| CN107789023A (en) * | 2016-08-30 | 2018-03-13 | 周佳蓉 | Blood vessel puncture sealing device |
| CN107802311A (en) * | 2017-11-20 | 2018-03-16 | 乐普（北京）医疗器械股份有限公司 | A kind of Wholly-degradable vessel sealing structure |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113940724A (en) * | 2021-12-01 | 2022-01-18 | 厦门大学附属中山医院 | False aneurysm sealer |
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Application publication date: 20190308 |
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