CN109394869A - Pu Rongshuan creams and preparation method thereof - Google Patents
Pu Rongshuan creams and preparation method thereof Download PDFInfo
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- CN109394869A CN109394869A CN201811552156.5A CN201811552156A CN109394869A CN 109394869 A CN109394869 A CN 109394869A CN 201811552156 A CN201811552156 A CN 201811552156A CN 109394869 A CN109394869 A CN 109394869A
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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Abstract
The present invention relates to a kind of Pu Rongshuan creams, with dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella etc. for raw material, emulsify and are prepared after extracted, purifying, evaporation and concentration.Beneficial effects of the present invention: raw material of the present invention is fresh raw material, including fresh dandelion, fresh cottonrose hibiscus leaf, fresh oldenlandia diffusa, fresh dried peppermint leaf and fresh centella, the effective component in raw material is remained to greatest extent, the loss for causing effective component because being dried to dry raw material is prevented, therapeutic effect is influenced.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Pu Rongshuan creams and preparation method thereof.
Background technique
Mammary gland is to belong to sexual organ, tissue by ovary estrogen and progestogen influenced and the physiological hyperplasia of generating period and
It restores, the cell hyperplasia of breast duct, leaflet or its surrounding connective tissue is then caused when meromorphosis, be referred to as mammary gland and increase
Raw disease (selecting from nineteen ninety-five, " TCM theory of cyclomastopathy " in " Journal of Traditional Chinese Medicine " of the 8th phase).The proliferation of mammary gland is clinical
Common disease, frequently-occurring disease, it is in rising trend in recent years.Every value is premenstrual or menstrual period breast make it is swollen, even turgor pain, or itches with nipple
Pain person, referred to as " distending pain of breasts during menstruation ".To occur swollen breasts in the last fortnight as cardinal symptom, severe one may occur in which this disease feature
Breast fullness has agglomeration, and symptom can periodically occur repeatedly.It is clinically to think that this disease and endocrine disturbance and mental element pierce more
Swash related (selecting from 2017, " treatment cyclomastopathy clinical observation " in " world's traditional Chinese medicine " of A01 phase).
In the prior art, it mostly uses dry powder or dry plate to fill raw material and carries out preparation creams, if carrying out preparation cream with fresh feed
Frost, is all made of the principle of now-making-now-using, but looks for fresh feed hardly possible, make trouble, is inconvenient to use, cannot store mutability for a long time
Matter.
Summary of the invention
It is of the existing technology in order to solve the problems, such as, the present invention provides a kind of Pu Rongshuan creams and preparation method thereof,
Overcome the fresh green herbal medicine of existing system and now do and now apply, manufactured lotion be easy to air-dry it is rotten, the shortcomings that cannot storing for a long time；The present invention
Pu Rongshuan creams be the milk knot that rises to adult female breast cyclomastopathy, mazoitis, cracked nipple, nursing breast distending pain
Block, skin wounds dampen swelling etc. and hurt the traditional Chinese medicine for outer use creams that disease has obvious curative effects, it is easier to store and patient is facilitated to make
With.
The object of the present invention is to provide a kind of Pu Rongshuan creams.
Another object of the present invention is to provide the preparation method of above-mentioned Pu Rongshuan creams.
The Pu Rongshuan creams of specific embodiment according to the present invention, the Pu Rongshuan creams are prepared by following raw material, institute
Stating raw material by weight includes: 12-16 parts of dandelion；8-12 parts of cottonrose hibiscus leaf；6-10 parts of oldenlandia diffusa；3-5 parts of dried peppermint leaf；
3-5 parts and Rosmarinic acid 0.6-1.0 parts of centella.
The Pu Rongshuan creams of specific embodiment according to the present invention, wherein the raw material include by camellia oil, beeswax,
The substrate material of lanolin and Arabic gum composition, the substrate material includes: 1-3 parts of camellia oil by weight；6-9 parts of beeswax；Sheep
4.0-4.5 parts of rouge of hair；4.0-4.5 parts of Arabic gum.
The Pu Rongshuan creams of specific embodiment according to the present invention, further, the Pu Rongshuan creams are by following original
Material preparation, the raw material includes: 14 parts of dandelion by weight；10 parts of cottonrose hibiscus leaf；8 parts of oldenlandia diffusa；4 parts of dried peppermint leaf；
4 parts of centella；0.8 part of Rosmarinic acid；2 parts of camellia oil；7.5 parts of beeswax；4.25 parts of lanolin；4.25 parts of Arabic gum.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, the described method comprises the following steps:
(1) it is cut after fresh dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella being removed impurity respectively
It is broken, it is mixed to form mixture, the mixture is put into continuous flow upstream ultrasonic and circulated extraction device, pure water is added and is mentioned
It takes, forms extracting solution；
(2) first the extracting solution that step (1) obtains is adsorbed by macroreticular resin, then is washed using ethyl alcohol
It is de-, obtain refined solution；
(3) refined solution that step (2) obtains is evaporated concentration, obtained and mixture etc. described in step (1)
The medicinal extract extracting solution of weight；
(4) after addition Rosmarinic acid is mixed into the medicinal extract extracting solution that step (3) obtains, pure water is added,
It is steam heated to 75-85 DEG C after mixing, is added in substrate material and is uniformly mixed, Rosa Damascana is then added, is uniformly mixed,
It is cooled into liquid lotion；
(5) the liquid lotion for obtaining step (4) emulsifies, then carries out being ground to fine-micron level degree, sterilizing
Afterwards up to the Pu Rongshuan creams.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein in step (4), the base
Material the preparation method comprises the following steps: weigh camellia oil, beeswax, lanolin and Arabic gum according to the ratio, be steam heated to after mixing completely
It is soluble and fused, is subsequently cooled to 75-85 DEG C, constant temperature is spare after filtering.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein described to be steam heated to 110
DEG C, substrate material is completely dissolved fusion, is subsequently cooled to 80 DEG C, and constant temperature is spare at 80 DEG C after filtering.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein described mixed in step (1)
The total amount of adding for closing material is the 40% of the Pu Rongshuan creams weight；In step (4), the total amount of adding of the substrate material is described
The 18% of Pu Rongshuan creams weight.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein described to mention in step (1)
Pure water is first added before taking and did not had mixture 1-2cm, impregnates 30 minutes, the mixture is then put into continuous flow upstream ultrasound and is followed
In ring extractor, adds pure water and extract；The total amount of adding of the pure water and the weight ratio of mixture are 240:
40；The temperature of the extraction is 60 DEG C, and the time of the extraction is 1 hour.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein described big in step (2)
Hole resin is LSA-21 macroreticular resin, and the ethyl alcohol is food grade ethyl alcohol.Macroporous absorbent resin be it is a kind of without cation exchange groups and
There is the preparation of macroporous structure, there is good macroreticular structure and biggish specific surface area, there can be selection
Ground passes through the organic matter in physical absorption aqueous solution.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein in step (3), the steaming
The temperature of hair concentration is 100 DEG C, and the time of the evaporation and concentration is 120 minutes.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein in step (4), be added to
It is 80 revs/min by revolving speed in substrate material be thoroughly mixed 40 minutes, Rosa Damascana is then added, it is small continues stirring 1
Shi Zhizhi is uniformly mixed.
The preparation method of the Pu Rongshuan creams of specific embodiment according to the present invention, wherein described to grind in step (5)
Mill uses colloid mill to be ground to fine granularity as 260 mesh, specifically: the liquid lotion is ground by 200 mesh fine granularities first, then is divided
5 circulating reflux millizations；260 mesh fine granularities finally are arranged in colloidal mill, all cremes are ground, up to the Pu after sterilizing
Rong feels well creams.
The sterilizing is using ultraviolet disinfection 4 hour, then is passed through ozone sterilization 8 hours, then to the refreshing cream of the Pu Rong
It is aseptic subpackaged by clean automatic air pressure filling machine progress that frost standing is placed on the workshop GMP for 24 hours.
The application method of Pu Rongshuan creams of the invention is applied 2 times a day according to affected part size and is smeared, and thickness is no more than
The Pu Rongshuan creams of the invention of 0.5mm clean after each chrisma creams half an hour.
Dandelion, dandelion herb be rich in vitamin A, vitamin C and potassium, also containing iron, calcium, vitamin B2, vitamin B1,
Magnesium, vitamin B6, folic acid and copper.Specific constituent content is mainly moisture, every 60 grams of dandelion herb leaves moisture content 86%, albumen
1.6 grams of matter, 5.3 grams of carbohydrate, there are about 108.8 kilojoules for heat.Contain taraxol, dandelion in dandelion plant
A variety of health-nutrition ingredients such as element, choline, organic acid, synanthrin.Nature and flavor are sweet, slight bitter, tremble with fear.Return liver, stomach meridian.There is diuresis, laxative, move back
Jaundice, cholagogue and other effects.It is swollen to control heat toxin, carbuncle swells, sore, internal carbuncle, red eye, swell pain, damp and hot, jaundice, the puckery pain of dribbling urination, furunculosis
Poison, acute mastitis, scrofula, toothache, hot eyes, pharyngalgia, pulmonary abscess, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.Control acute mastitis, lymph gland
Inflammation, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, gall-bladder
Inflammation, urinary tract infections etc..Anti-inflammation detumescence pharmacodynamic raw materials compatibility is used as in the present invention.Dandelion is that clinic important simply commonly uses medium-height grass
The effect of medicine integrates medicinal and edible, Ju You Cheongju thermal detoxification, dispersing swelling and dissipating binds and inducing diuresis for treating strangurtia.Clinically it is mainly used for controlling
Treat the diseases such as acute mastitis, scrofula, furuncle swelling toxin, pharyngalgia, pulmonary abscess, acute appendicitis, hot eyes, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.Pharmacological testing shows
Dandelion has broad-spectrum antiseptic, Hepatoprotective cholagogue, antiendotoxin, stomach invigorating and immunologic enhancement.
Cottonrose hibiscus leaf, acrid flavour are mild-natured；Return lung, Liver Channel；With cool blood, detoxify, the effect of detumescence, analgesic.For ulcer larynx
Swollen, be burdened with She Dan, scald, red eye, swell pain, traumatic injury.Anti-inflammation detumescence pharmacodynamic raw materials compatibility is used as in the present invention.
Oldenlandia diffusa, it is bitter, light, it is cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness.Cure mainly lung heat
It breathes with cough, abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, puckery pain of heat gonorrhea, oedema, dysentery, enteritis, jaundice with damp-heat pathogen, You Shanzhi
Treat various types inflammation and cancerous swelling；Immunity can be enhanced, there is tumor suppression, inhibit production of sperm, antivenomous effect.Make in the present invention
For medicinal powder for relieving pain knot pharmacodynamic raw materials compatibility.Oldenlandia diffusa contains a variety of chemical components such as Anthraquinones, flavonoids, terpene, has and exempts from
Epidemic disease adjusts, is antitumor, anti-oxidant, anti-chemical mutagenesis, anti-inflammatory, antibacterial, Hepatoprotective cholagogue, analgesia removing toxic substances and other effects.
Dried peppermint leaf can improve sense Mao fever, throat, swelling and pain, and eliminate head with stomach invigorating wind-dispelling, eliminating the phlegm, cholagogue, anti-spasm
Bitterly, toothache, nausea sense.It is also commonly used for production cooking or dessert, to remove fish and mutton fishy smell, or collocation fruit and dessert, is used
To render palatable；It may be alternatively configured the lotion of anti-inflammation detumescence.Refrigerant throat-moistening specific to peppermint and the pleasant smell of fragrance covering up and
Improve some senses of discomfort that there is peculiar smell and be difficult to the drug swallowed.Peppermint Water topical application has refrigerant, antipruritic, anti-inflammatory, analgesic
The effect of.Menthol can stimulate cutaneous nerve tip receptor, first generate cool feeling, then there is slight burning heat sensation.Slowly
In the saturating fell in ground, cause prolonged hyperemia, and reaches therapeutic effect；Antipyretic: a small amount of peppermint energy stimulating central nervous systems make surrounding
Telangiectasis and radiate；And promote sweat gland secretion and sweating.Therefore there is the hypothermic effect of drop；It is anti-inflammatory: 8 contained by peppermint
Kind of catechu naphthols acid is effective anti-inflammatory agent, can inhibit mono- hydroxysteroid dehydrogenase of 3a and have weak from anti-inflammatory effect.Contained by peppermint
Blue sesame oil hydrocarbon have anti-inflammatory effect to Scalded Rabbits ear.It is used as analgesic, antipyretic, anti-inflammation detumescence pharmacodynamic raw materials compatibility in the present invention,
Also antisepsis is played.
Centella, all herbal medicine, clearing heat and promoting diuresis, subdhing swelling and detoxicating, control acute diseases such as cholera and sunstroke xenon abdominal pain, heat rushes down, dysentery, jaundice with damp-heat pathogen, sand leaching,
Blood strangury is spat, blood, hemoptysis, hot eyes, larynx are swollen, rubeola, scabies, malignant boil carbuncle swells poison, traumatic injury etc..Inhibit proliferation of fibrous tissue: accumulated snow
Careless glycosides can inhibit collagenous fibres, have the function of inhibiting proliferation of fibrous tissue.Promote skin growth: it is raw that rabbit intramuscular injection can promote skin
Long, local leukocytosis, connective tissue rete vasculosum increases, and mucilage secretion increases, and fur hyperplasia accelerates, and has and skin is inhibited to burst
The effect of ulcer；The stable effect of calmness: centella glucoside contained therein has calm, stable effect to mouse, rat, this effect is main
It is the influence of the cholinergic system in Central nervous system.Alcohol extracting thing is without analgesic activity；Effect to skin histology: accumulated snow
Careless glucoside can treat skin ulcer, such as obstinate sexual trauma, cutaneous tuberculosis, leprosy；Mouse, cavy, rabbit muscle are injected or subcutaneous
Implantation can promote skin growth, local leukocytosis, connective tissue rete vasculosum hyperplasia, mucous secretion increase, the life of hair and tail
Long acceleration etc.；Clearing heat and promoting diuresis: treatment abscess of throat, aphthae, headache, body heat are thirsty etc.；Activating microcirculation and removing stasis medicinal: swollen for bruise
Bitterly, worm snake bite, redness and swelling of joints etc.；Antibacterial anti-inflammatory: shingles zoster caused by treating because of virus or bacterium, dysentery, damp and hot Huang
Subcutaneous ulcer, oedema, stranguria.It can also be used for erysipelas, scrofula, close pyogenic infections from tumour or sore；Li Shui and spleen: treatment is because of watery diarrhea caused by damp and hot, dysentery, also
For gasteremphraxis have a stomachache, stomach Qi not under, indigestion, gasteremphraxis hiccup, children's infantile malnutrition symptom；Anastalsis: hematuria, bleeding from five sense organs or subcutaneous tissue, pain are used for
Through various bleedings such as, metrorrhagia and metrostaxis, hematochezia, hemorrhoid hemorrhage, gastrorrhagia, traumatic hemorrhage, there is hemostasis and pain-relieving；Improve memory:
Modern medical research has found that centella really has the effect of promoting memory, rosemary also has similar effect, hears one often
Essential oil made of rosemary is heard, brain stress hormone cortisol is adjusted, you is allowed to keep awake the moment；Other effects: alcohol extracting
Object can relax isolated rat ileum, and glucoside part can reduce the tension and shrinkage amplitude of rabbit and isolated rat ileum, and can be slight
Inhibit the effect of acetylcholine.To anesthetized dog, intravenous injection can slight excited breathing, heart rate is slack-off and moderate reduces blood pressure,
The latter two cannot have been reported that asiaticoside has therapeutic effect to leprosy by That atropine blocks.In the present invention as detumescence, inhibition
Hyperplasia pharmacodynamic raw materials compatibility.
Rosmarinic acid, has a stronger anti-inflammatory activity, while Rosmarinic acid also has anti-oxidant, antibacterial, antiviral, anti-swollen
The activity of tumor.Also there is antidepression and the stabilization to color, to the inhibiting effect of hyaluronidase, to xanthine oxidase
Inhibiting effect, liver protection effect, inhibit angiogenesis function, prevent artery sclerosis from acting on, prevent memory impairment etc..In the present invention
Middle preservative anti-oxidant, antibacterial as medicinal extract liquid.
Camellia oil, the fatty acid contained have 5 palmitinic acid, stearic acid, arachidic acid, oleic acid and linoleic acid (C18:2) components,
Wherein oleic acid and linoleic acid account for 76.79%.Also contain camellianin, tea polyphenols, saponin, tannin, and is rich in antioxidant and has
The squalene of anti-inflammatory effect, squalene and Flavonoid substances play the role of anticancer splendid.Camellia oil is also rich in vitamin E
With the microelements such as calcium, iron, zinc.Immune, anti anoxia and antifatigue, low-temperature resistance stress, lipid peroxidation inhibition, anti-with bidirectional modulation
Mutagenesis has the effects of adjusting, kidney tonifying thrombus dissolving to kidney.The tea polyphenols wherein contained have anti-aging, it is anti-radiation, to cancer cell
Inhibition, antibacterial, sterilization, the inhibiting effect to AIDS virus, to the anti-Xie Zuoyong of heavy metallic salt and biological alkalosis；Protect tooth
Improving eyesight and the effect for removing halitosis；Digestion-aid effect；Enhance capilary obdurability, reducing blood lipid, prevents liver and coronary artery congee
Sample hardening；Blood pressure lowering, it is hypoglycemic, prevent headstroke, antithrombotic, antiallergic action and cutaneous anaphylaxis, stomach of releiving it is nervous,
Anti- inflammation antidiarrheal and diuresis, the absorption for promoting Vc, prevention and treatment scurvy；Absorption of the human body to iron is improved, anaemia is effectively prevent.Have
Help inhibit cardiovascular disease, beauty and skin care, arousing brain, raising spirit, diuresis is recovered from fatigue, lipid-loweringing is aid digestion, reduce cholesterol, pre- preventing tumor.
In the present invention as reparation one of skin drug effect compatibility and emulsifier of the invention.
Lanolin, main component are that sterols, fatty alcohols and triterpene alcohols and the fatty acid of about equivalent are generated
Ester, account for about 95%, also contain free alcohol 4%, and have a small amount of free fatty acid and hydrocarbons.Lanolin can allow skin
It is smooth tender.Water-in-oil emulsifier can be done, is excellent moistness substance.It can make to dry because lacking natural moisture or coarse
Dermalaxia and be restored.It is rather than moisture to be prevent completely to maintain the skin usual through epidermis by delay
Water content.Main ingredient can be made to be absorbed by mucous membrane and skin rapidly, there is adhesive force, property is stablized, and can absorb water, and is not easy rancid.Make
For one of emulsifier of the invention and water imbibition emulsifiable paste matrix.
Arabic gum, Arabic gum main component are high molecular polysaccharide and its calcium, magnesium and sylvite, mainly include natural gum
Aldose, galactolipin, glucuronic acid etc..Arabic gum has very good amphipathic property, is extraordinary natural oil-in-water
Type emulsion stabilizer；With good emulsification property, it is the hydrosol that purposes is wider in food industry, stabilizer can be made；Also have
There is the function of reducing Blood Cholesterol.As emulsifier and stabilizer of the invention.
Beeswax, sweet, tepor.Have inducing astrigency, sore, myogenic, analgesic, conditioning and other effects.Apply affected part, often make patent medicine excipients and
Ointment bases.Main ingredient has: the pure and mild carbohydrate of acids, free fatty acid, free-fat.In addition, there are also carotenoids
Element, vitamin A, aromatic substance etc..Beeswax has antibacterial and antisepsis.Paste sore myogenic pain relieving.Beeswax in the present invention is as cream
Agent, excipients and emulsifiable paste matrix.Also make myogenic pain relieving drug effect compatibility.
Rosa Damascana contains β-damascone (β-damascone), rose oxide (roseoxide), a- common perilla alkene.Flower also contains
Quercetin (quercetin), corn flower double glucoside (cyanin), organic acid, beta carotene (β-carotene), fat oils etc..
Rosa Damascana in the present invention is as aromatic.
The effect of Pu Rongshuan creams of the invention are as follows: (1) relieve pain dissipating bind；(2) prevention infection；(3) hemostasis and anti-inflammation；(4) it dissipates
Stagnation resolvation is swollen；(5) it prevents from festering；(6) face is hurt in healing of wound, reparation.
Compared with prior art, the invention has the following beneficial effects:
(1) prior art is all to carry out high temperature refinement using dry powder or drying sheet-shaped material, and raw material is in drying process
In, because of high-temperature process overlong time or period of storage is too long that original effective component is caused to be largely lost.It is of the present invention
Raw material is fresh raw material, including fresh dandelion, fresh cottonrose hibiscus leaf, fresh oldenlandia diffusa, fresh thin
Lotus leaf and fresh centella remain the effective component in raw material to greatest extent, prevent from causing because being dried to dry raw material
The loss of effective component, influences therapeutic effect；
(2) raw material of the invention is food grade raw material, reduces influence of the chemical industry steroids raw material to human body；Make ointment
Agent creams are safer, it is abundant to work；The adverse reaction for reducing drug allergy, expands the application range of crowd；
(3) the present invention overcomes the trouble of now-making-now-using in the prior art and perishable disadvantages, using modernization process
It is produced into finished product, it is ensured that make have convenience, long term guarantee quality storage, effect consistent.
(4) the smearing time is short, with other kinds of drugs as integrated the paste phases such as erythromycin ointment, Hibisci Paste used in wound
Than can significantly reduce administration time, shorten the course of disease, save spending, improve rehabilitation rate；Blister will not be played after painting, applied
With or so half an hour, so that it may clean, will not both delay working, will not influence to rest；It is clinical quick, it is long to reduce patient
Time insufferable pain；
(5) Pu Rongshuan creams of the invention have a wide range of application, and this product has for adult female's cyclomastopathy, mazoitis
Unsting, reduce swelling, cracked nipple of healing, anti-inflammatory, dissipating bind the effect of；General wound in surgery, such as: nail, bamboo and wood are stabbed, bruise
Damage, felon etc. all can be effective；It is to be applicable in more performances, the comprehensive medicament creams of multi-functional external application；
(6) simultaneous treatment of principal and subordinate symptoms.Pu Rongshuan creams of the invention are improved in technique, and fresh feed is effective by extracting
Ingredient is mutually compatible and is emulsified into the finished product of specification, and herbal medicine cream is allowed sufficiently to volatilize, permeate, simultaneous treatment of principal and subordinate symptoms in use, can be with
Collaboration doctor's advice takes taking for product orally.
In the present invention, each raw material component and its proportion are extremely crucial, after knowing above-mentioned each component and proportion, this field
Those of ordinary skill can be used various conventional traditional Chinese medicine extyaction methods and carry out effective component extracting, as decocting method, water mention
Alcohol deposition method, salting out method, organic solvent extraction etc. can obtain the main medicine in aforementioned Chinese medicine preparation due to said extracted method
Imitate ingredient, therefore can unsting, reduce swelling to mazoitis, dissipating bind have certain curative effect.
Wherein, organic solvent extraction are as follows: press one with the common solvents such as ethyl acetate, acetic acid, triethylamine and ethyl alcohol or water
After certainty ratio mixing, the specific effective component in medicinal material is targetedly extracted.It is extractable out by organic solvent extraction
The higher specific effective component of purity.
The method of the concentration includes but is not limited to: atmospheric evaporation, reduction vaporization, thin film evaporation, multiple-effect evaporation, purifying
Method includes but is not limited to: method of purification of saltouing, macroporous resin adsorption method of purification, ethanol precipitation method of purification, to change resin pure for ion effect
Change method, flocculation sedimentation method of purification, membrane separating and purifying method, polycaprolactam method of purification, silica gel absorption chromatographic purifying etc..
Dry method includes but is not limited to: oven drying method, drum-type seasoning, belt drying method, hygroscopic desiccation method, boiling are dry
Dry method, spray drying process, hypobaric drying method, freeze-drying, infrared drying, micro-wave drying method etc..
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
A kind of Pu Rongshuan creams are present embodiments provided, are prepared by following raw material: dandelion 14kg；Cottonrose hibiscus leaf 10kg；
Oldenlandia diffusa 8kg；Dried peppermint leaf 4kg；Centella 4kg and Rosmarinic acid 0.8kg.
Preparation method, comprising the following steps:
(1) it is cut after fresh dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella being removed impurity respectively
It is broken, it is mixed to form mixture, the mixture is put into continuous flow upstream ultrasonic and circulated extraction device, pure water is added and is mentioned
It takes, forms extracting solution；
(2) first the extracting solution that step (1) obtains is adsorbed by macroreticular resin, then is washed using ethyl alcohol
It is de-, obtain refined solution；
(3) refined solution that step (2) obtains is evaporated concentration, obtained and mixture etc. described in step (1)
The medicinal extract extracting solution of weight；
(4) after addition Rosmarinic acid is mixed into the medicinal extract extracting solution that step (3) obtains, pure water is added,
It is steam heated to 75-85 DEG C after mixing, is added in substrate material and is uniformly mixed, Rosa Damascana is then added, is uniformly mixed,
It is cooled into liquid lotion；Substrate material is mixed by weight for 1:1 by beeswax and grape seed oil；
(5) the liquid lotion for obtaining step (4) emulsifies, then carries out being ground to fine-micron level degree, sterilizing
Afterwards up to the Pu Rongshuan creams.
Embodiment 2
A kind of Pu Rongshuan creams are present embodiments provided, are prepared by following raw material:
Dandelion 16kg；Cottonrose hibiscus leaf 8kg；Oldenlandia diffusa 10kg；Dried peppermint leaf 5kg；Centella 3kg；Rosmarinic acid
1.0kg；Camellia oil 1kg；Beeswax 9kg；Lanolin 4.0kg；Arabic gum 4.5kg.
Preparation method, comprising the following steps:
(1) fresh dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella are weighed, fresh dandelion,
Cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and the total amount of adding of centella be finished weight 40%, by fresh dandelion,
Cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella are shredded after removing impurity respectively, are mixed to form mixture, are put into pure
Water did not had mixture 2cm, and the mixture is put into continuous flow upstream ultrasonic and circulated extraction device, and pure water is added and is uniformly mixed,
The total amount of adding of pure water and the weight ratio of mixture are 240:40, extract 1 hour at 60 DEG C, form extracting solution；
(2) first the extracting solution that step (1) obtains is adsorbed by LSA-21 macroreticular resin, then uses food grade
Ethyl alcohol is eluted, and refined solution is obtained；
(3) refined solution that step (2) obtains is evaporated at 100 DEG C concentration 120 minutes, obtained and step
(1) the medicinal extract extracting solution of the weight such as the mixture described in；
(4) weigh substrate material according to the ratio, the total amount of adding of substrate material is the 18% of finished weight, including camellia oil, beeswax,
Lanolin and Arabic gum are steam heated to 110 DEG C after mixing, substrate material is completely dissolved fusion, are subsequently cooled to 75 DEG C, filtering
Constant temperature is kept spare afterwards；After into the medicinal extract extracting solution that step (3) obtains, addition Rosmarinic acid is mixed, it is added pure
Water is steam heated to 75 DEG C after mixing, is added in substrate material and carries out being thoroughly mixed 40 for 80 revs/min by revolving speed
Minute, Rosa Damascana is then added, continues stirring 1 hour until being uniformly mixed, is cooled into liquid lotion；
(5) the liquid lotion for obtaining step (4) emulsifies, then, first that the liquid lotion is thin by 200 mesh
Granularity is ground, then divides 5 circulating reflux millizations；260 mesh fine granularities finally are arranged in colloidal mill, all cremes are ground, most
Afterwards, using ultraviolet disinfection 4 hours, then ozone sterilization is passed through 8 hours to get the Pu Rongshuan creams, to the refreshing cream of the Pu Rong
It is aseptic subpackaged by clean automatic air pressure filling machine progress that frost standing is placed on the workshop GMP for 24 hours.
Embodiment 3
A kind of Pu Rongshuan creams are present embodiments provided, are prepared by following raw material:
Dandelion 12kg；Cottonrose hibiscus leaf 12kg；Oldenlandia diffusa 6kg；Dried peppermint leaf 3kg；Centella 5kg；Rosmarinic acid
0.6kg；Camellia oil 3kg；Beeswax 6kg；Lanolin 4.5kg；Arabic gum 4.0kg.
Preparation method, comprising the following steps:
(1) fresh dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella are weighed, fresh dandelion,
Cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and the total amount of adding of centella be finished weight 40%, by fresh dandelion,
Cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella are shredded after removing impurity respectively, are mixed to form mixture, are put into pure
Water did not had mixture 1cm, and the mixture is put into continuous flow upstream ultrasonic and circulated extraction device, and pure water is added and is uniformly mixed,
The total amount of adding of pure water and the weight ratio of mixture are 240:40, extract 1 hour at 60 DEG C, form extracting solution；
(2) first the extracting solution that step (1) obtains is adsorbed by LSA-21 macroreticular resin, then uses food grade
Ethyl alcohol is eluted, and refined solution is obtained；
(3) refined solution that step (2) obtains is evaporated at 100 DEG C concentration 120 minutes, obtained and step
(1) the medicinal extract extracting solution of the weight such as the mixture described in；
(4) weigh substrate material according to the ratio, the total amount of adding of substrate material is the 18% of finished weight, including camellia oil, beeswax,
Lanolin and Arabic gum are steam heated to 110 DEG C after mixing, substrate material is completely dissolved fusion, are subsequently cooled to 85 DEG C, filtering
Constant temperature is kept spare afterwards；After into the medicinal extract extracting solution that step (3) obtains, addition Rosmarinic acid is mixed, it is added pure
Water is steam heated to 85 DEG C after mixing, is added in substrate material and carries out being thoroughly mixed 40 for 80 revs/min by revolving speed
Minute, Rosa Damascana is then added, continues stirring 1 hour until being uniformly mixed, is cooled into liquid lotion；
(5) the liquid lotion for obtaining step (4) emulsifies, then, first that the liquid lotion is thin by 200 mesh
Granularity is ground, then divides 5 circulating reflux millizations；260 mesh fine granularities finally are arranged in colloidal mill, all cremes are ground, most
Afterwards, using ultraviolet disinfection 4 hours, then ozone sterilization is passed through 8 hours to get the Pu Rongshuan creams, to the refreshing cream of the Pu Rong
It is aseptic subpackaged by clean automatic air pressure filling machine progress that frost standing is placed on the workshop GMP for 24 hours.
Embodiment 4
A kind of Pu Rongshuan creams are present embodiments provided, are prepared by following raw material:
Dandelion 14kg；Cottonrose hibiscus leaf 10kg；Oldenlandia diffusa 8kg；Dried peppermint leaf 4kg；Centella 4kg；Rosmarinic acid
0.8kg；Camellia oil 2kg；Beeswax 7.5kg；Lanolin 4.25kg；Arabic gum 4.25kg.
Preparation method, comprising the following steps:
(1) fresh dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella are weighed, fresh dandelion,
Cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and the total amount of adding of centella be finished weight 40%, by fresh dandelion,
Cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella are shredded after removing impurity respectively, are mixed to form mixture, are put into pure
Water did not had mixture 2cm, and the mixture is put into continuous flow upstream ultrasonic and circulated extraction device, and pure water is added and is uniformly mixed,
The total amount of adding of pure water and the weight ratio of mixture are 240:40, extract 1 hour at 60 DEG C, form extracting solution；
(2) first the extracting solution that step (1) obtains is adsorbed by LSA-21 macroreticular resin, then uses food grade
Ethyl alcohol is eluted, and refined solution is obtained；
(3) refined solution that step (2) obtains is evaporated at 100 DEG C concentration 120 minutes, obtained and step
(1) the medicinal extract extracting solution of the weight such as the mixture described in；
(4) weigh substrate material according to the ratio, the total amount of adding of substrate material is the 18% of finished weight, including camellia oil, beeswax,
Lanolin and Arabic gum are steam heated to 110 DEG C after mixing, substrate material is completely dissolved fusion, are subsequently cooled to 80 DEG C, filtering
Constant temperature is kept spare afterwards；After into the medicinal extract extracting solution that step (3) obtains, addition Rosmarinic acid is mixed, it is added pure
Water is steam heated to 80 DEG C after mixing, is added in substrate material and carries out being thoroughly mixed 40 for 80 revs/min by revolving speed
Minute, Rosa Damascana is then added, continues stirring 1 hour until being uniformly mixed, is cooled into liquid lotion；
(5) the liquid lotion for obtaining step (4) emulsifies, then, first that the liquid lotion is thin by 200 mesh
Granularity is ground, then divides 5 circulating reflux millizations；260 mesh fine granularities finally are arranged in colloidal mill, all cremes are ground, most
Afterwards, using ultraviolet disinfection 4 hours, then ozone sterilization is passed through 8 hours to get the Pu Rongshuan creams, to the refreshing cream of the Pu Rong
It is aseptic subpackaged by clean automatic air pressure filling machine progress that frost standing is placed on the workshop GMP for 24 hours.
The application method of Pu Rongshuan creams of the invention is applied 2 times a day according to affected part size and is smeared, and thickness is no more than
The Pu Rongshuan creams of the invention of 0.5mm clean after each chrisma creams half an hour.
The content of effective component is more in Pu Rongshuan creams provided by the invention, has preferably treatment mazoitis and cream
The effect of gland hyperplasia；It can be with strengthen immunity.It is found in follow-up follow-up observation, treatment silver bits of the invention provided by the invention
The Chinese medicine composition of disease is day using the time, applies smear Pu Rongshuan creams of the invention 2 times a day, each topical application of drug half an hour, have
The preferably effect for the treatment of psoriasis.
Original formulation of the invention is family's ointment secret recipe of place treatment mammary gland and skin disease, in Guangdong province, China Chaozhou-Shantou region
Now green grass ointment processed is applied to medicinal for the regional long-term external application as treatment mazoitis and scytitis；Improved cost hair
Bright Pu Rongshuan emulsifiable paste, it is prefabricated to be packaged into emulsification ointment, and by Chaozhou Zhu Yangtang health-care room, Tian Chuan vocational school, time of childbirth club, the moon
Health hall stimulating milk secretion teacher services Dian Dengge service unit and starts tissue to having the proliferation of mammary gland and other mammitis, skin in 2018.3.12
Skin inflammation is carried out 3 months efficacy validations by object is treated；It is applied 2 times a day according to affected part size and smears the refreshing cream of Pu Rong of the invention
Frost cleans after each chrisma creams half an hour；Through counting:
(1) lactation mastitis disease is by treating 61 people of object, and 40 are relieved pain by treating object and reach for application 2 times on day 1
Knot effect is changed in swelling；13 are reached detumescenceization knot effect of unstinging by object is treated on day 2, and 7 are reached on day 3 by object is treated
The effect of detumescenceization of unstinging knot；1 by treating, object was relieved pain at first 3 days, agglomerating does not dissipate.
(2) cyclomastopathy female patient is by treating object 57, and the application before official holiday monthly, 35 by treatment object first
It is relieved pain, softening is agglomerated, 14 by treat second day pain of object disappear, smallization of agglomerating, 6 by treating object third day pain
It disappears bitterly, smallization of agglomerating.2 by treat object first three days reach relieve pain to pain disappear, unobvious smallization of agglomeration.
(3) stab, bruise turn round bruise, felon, cracked nipple patient by treat object 22；There are stasis of blood the wounded 9,
All reach within one day anti-inflammatory analgesic, the effect of quick stagnation resolvation；There are laceration of skin purulence inflammation person 13 discharges of first day wound stasis of blood purulence, healings
Incrustation, third day wound start decrustation myogenic.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of Pu Rongshuan creams, which is characterized in that the Pu Rongshuan creams are prepared by following raw material, and the raw material is by weight
It include: 12-16 parts of dandelion；8-12 parts of cottonrose hibiscus leaf；6-10 parts of oldenlandia diffusa；3-5 parts of dried peppermint leaf；3-5 parts of centella and
0.6-1.0 parts of Rosmarinic acid.
2. Pu Rongshuan creams according to claim 1, which is characterized in that the raw material includes by camellia oil, beeswax, wool
The substrate material of rouge and Arabic gum composition, the substrate material includes: 1-3 parts of camellia oil by weight；6-9 parts of beeswax；Lanolin
4.0-4.5 part；4.0-4.5 parts of Arabic gum.
3. Pu Rongshuan creams according to claim 2, which is characterized in that the Pu Rongshuan creams are prepared by following raw material,
The raw material includes: 14 parts of dandelion by weight；10 parts of cottonrose hibiscus leaf；8 parts of oldenlandia diffusa；4 parts of dried peppermint leaf；Centella 4
Part；0.8 part of Rosmarinic acid；2 parts of camellia oil；7.5 parts of beeswax；4.25 parts of lanolin；4.25 parts of Arabic gum.
4. the method for preparing any Pu Rongshuan creams of claim 1-3, which is characterized in that the method includes following steps
It is rapid:
(1) it shreds, mixes after fresh dandelion, cottonrose hibiscus leaf, oldenlandia diffusa, dried peppermint leaf and centella being removed impurity respectively
Conjunction forms mixture, and the mixture is put into continuous flow upstream ultrasonic and circulated extraction device, and pure water is added and extracts, is formed
Extracting solution；
(2) first the extracting solution that step (1) obtains is adsorbed by macroreticular resin, then is eluted using ethyl alcohol, obtained
To refined solution；
(3) refined solution that step (2) obtains is evaporated concentration, obtained and the weight such as mixture described in step (1)
Medicinal extract extracting solution；
(4) after addition Rosmarinic acid is mixed into the medicinal extract extracting solution that step (3) obtains, pure water, mixing is added
It is steam heated to 75-85 DEG C after uniformly, is added in substrate material and is uniformly mixed, Rosa Damascana is then added, is uniformly mixed, it is cooling
Form liquid lotion；
(5) the liquid lotion for obtaining step (4) emulsifies, then carries out being ground to fine-micron level degree, after sterilizing i.e.
Obtain the Pu Rongshuan creams.
5. the preparation method of Pu Rongshuan creams according to claim 4, which is characterized in that in step (4), the substrate material
The preparation method comprises the following steps: weigh camellia oil, beeswax, lanolin and Arabic gum according to the ratio, be steam heated to and be completely dissolved after mixing
Fusion, is subsequently cooled to 75-85 DEG C, constant temperature is spare after filtering.
6. the preparation method of Pu Rongshuan creams according to claim 5, which is characterized in that it is described to be steam heated to 110 DEG C,
Substrate material is completely dissolved fusion, is subsequently cooled to 80 DEG C, and constant temperature is spare at 80 DEG C after filtering.
7. the preparation method of Pu Rongshuan creams according to claim 4, which is characterized in that in step (1), the mixture
Total amount of adding be the Pu Rongshuan creams weight 40%；In step (4), the total amount of adding of the substrate material is the Pu Rong
The 18% of refreshing creams weight.
8. the preparation method of Pu Rongshuan creams according to claim 4, which is characterized in that in step (1), before the extraction
Pure water is first added and did not had mixture 1-2cm, impregnates 30 minutes, the mixture is then put into continuous flow upstream ultrasonic circulation and is mentioned
It takes in device, adds pure water and extract；The total amount of adding of the pure water and the weight ratio of mixture are 240:40；Institute
The temperature for stating extraction is 60 DEG C, and the time of the extraction is 1 hour.
9. the preparation method of Pu Rongshuan creams according to claim 4, which is characterized in that in step (2), the macropore tree
Rouge is LSA-21 macroreticular resin, and the ethyl alcohol is food grade ethyl alcohol.
10. the preparation method of Pu Rongshuan creams according to claim 4, which is characterized in that in step (3), the evaporation
The temperature of concentration is 100 DEG C, and the time of the evaporation and concentration is 120 minutes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116549575A (en) * | 2023-02-09 | 2023-08-08 | 天津市武清区爱康中医医院 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116549575A (en) * | 2023-02-09 | 2023-08-08 | 天津市武清区爱康中医医院 | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and preparation method thereof |
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