CN109394585A - A kind of anti-oxidant and moisturizing liquid-crystal composition and its preparation method and application - Google Patents
A kind of anti-oxidant and moisturizing liquid-crystal composition and its preparation method and application Download PDFInfo
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- CN109394585A CN109394585A CN201811503801.4A CN201811503801A CN109394585A CN 109394585 A CN109394585 A CN 109394585A CN 201811503801 A CN201811503801 A CN 201811503801A CN 109394585 A CN109394585 A CN 109394585A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to daily chemical products technical field, a kind of anti-oxidant and moisturizing liquid-crystal composition and its preparation method and application is disclosed.Liquid-crystal composition of the present invention includes 0.01~5% ophiopogonpolysaccharide, and silybum marianum seed oil 0.5~15%, emulsifier 1~20%, assistant for emulsifying agent 1~20%, liquid fat 5~35%, thickener 0.01~5%, preservative 0.1~10%, surplus is water.The present invention is by containing silybum marianum seed oil and ophiopogonpolysaccharide in the liquid crystal structure of special material combination preparation, and overall stability is high, and liquid crystal structure is complete；Good closed system can be formed on the skin, enhances the aquation of skin, and performance of keeping humidity and anti-oxidation efficacy are significant, have a good application prospect in cosmetic field.
Description
Technical field
The present invention relates to daily chemical products technical field, in particular to a kind of anti-oxidant and moisturizing liquid-crystal composition and its preparations
Methods and applications.
Background technique
In daily skin care, moisturizing and it is anti-oxidant be guarantee skin health, anti-aging essential condition.In recent years
Come, for the toxicity and irritating doubt to chemical toilet, more and more scientific researchers tend to from natural plants
It is middle to find safe and efficient moisturizing oxidation-resistant active ingredient.Ophiopogonpolysaccharide is the natural plant polyose extracted from Radix Ophiopogonis, is had
Preserving youthful looks, moisturizing, fertilizer is strong, black hair, anti-aging function, and moisture can be absorbed from atmosphere makes skin keep wetting, can also be deep from skin
Layer absorbs moisture, reaches moistening effect.Silybum marianum seed oil is from compositae plant milk thistle (Silybum marianum Gaertn)
It is refined in fruit through techniques such as cold fried, filterings.Silybum marianum seed oil is rich in vitamin E and its derivative and phytosterol,
With free radical is removed, oxidation resistant effect can also increase the elasticity and water-retaining property of skin, and skin is kept to continue water profit.Water
Flying Ji seed oil is common a active constituent in current high-end cosmetics.
The current carrier technique patent in relation to silybum marianum seed oil and ophiopogonpolysaccharide is less, how to improve the active constituent of the two
And the stability of holding product entirety is the research emphasis of novel carriers technology.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of anti-oxidant and moisturizing liquid-crystal composition and preparation method thereof,
So that the liquid-crystal composition is provided with higher stability under low temperature, illumination, high temperature and room temperature；
Another object of the present invention is that providing a kind of anti-oxidant and moisturizing liquid-crystal composition and preparation method thereof, make
The product that the liquid-crystal composition is obtained compared to identical active constituent has higher performance of keeping humidity and antioxidation；
Another object of the present invention is that providing above-mentioned liquid-crystal composition is preparing the related application in daily chemical products.
For achieving the above object, the invention provides the following technical scheme:
A kind of anti-oxidant and moisturizing liquid-crystal composition, including 0.01~5% ophiopogonpolysaccharide, silybum marianum seed oil 0.5~15%,
Emulsifier 1~20%, assistant for emulsifying agent 1~20%, liquid fat 5~35%, thickener 0.01~5%, preservative 0.1~
10%, surplus is water；The % is mass percent.
Wherein, the ophiopogonpolysaccharide mass percent is preferably 0.05~4%, and more preferably 0.1~2%, it is further excellent
It is selected as 0.5~1%；In the specific embodiment of the invention, the ophiopogonpolysaccharide mass percent be 0.01%, 0.02%,
0.05%, 0.1%, 0.5%, 0.8%, 1%, 2%, 3%, 4% or 5%；
The silybum marianum seed oil mass percent is preferably 1%~12%, and more preferably 2%~10%, further preferably
It is 4~8%；In the specific embodiment of the invention, the silybum marianum seed oil mass percent be 0.5%, 1%, 2%, 4%,
5%, 6%, 7%, 8%, 10%, 12% or 15%；
The emulsifier mass percent is preferably 3%~18%, more preferably 5%~15%, further preferably 8~
12%；In the specific embodiment of the invention, the mass percent of the emulsifier is 3%, 7%, 20%, 5%, 8%,
15%, 9%, 8.5%, 4% or 6%；
The emulsifier is PEG-20 methyl sesquistearate, stereth -21, stereth -2, gathers
The two stearic acid ester of glycerol -6, -3 beeswax acid esters of polyglycereol, C14-22 alcohol/C12-20 alkyl glucoside, arachidic alcohol glucoside, 16
Pure and mild 16 octadecyl glycosides of octadecyl, the pure and mild eicosyl glucoside of eicosyl docosyl, coco group Portugal
One or more of polyglycoside and the pure and mild coco group glucoside of lauric alcohol, 16 octadecyls, hydrolecithin it is mixed
Close object.When the emulsifier is the mixture of many kinds of substance, the present invention is to the ratio of each component in the mixture without spy
Different limitation；In the specific embodiment of the invention, one of described emulsifier selection mentioned emulsifier, two or three；Example
Such as:
C14-22 alcohol/C12-20 alkyl glucoside+hydrolecithin；
Coco group glucoside and lauric alcohol+arachidic alcohol glucoside+hydrolecithin；
The pure and mild eicosyl glucoside+PEG-20 methyl sesquistearate+ten of eicosyl docosyl
The pure and mild coco group glucoside of six octadecyls；
Stereth -21+ stereth -2；
The pure and mild eicosyl glucose of pure and mild 16 octadecyl glycosides of 16 octadecyls+eicosyl docosyl
Glycosides；
The two stearic acid ester of polyglycereol -6+pure and mild eicosyl glucoside+C14-22 alcohol of eicosyl docosyl/
C12-20 alkyl glucoside；
- 3 beeswax acid esters of pure and mild 16 octadecyl glycosides of 16 octadecyls+polyglycereol+hydrolecithin；
The two stearic acid ester of polyglycereol -6+pure and mild eicosyl glucoside+C14-22 alcohol of eicosyl docosyl/
C12-20 alkyl glucoside；
The pure and mild 16 octadecyl sugar of pure and mild+ten six octadecyl of eicosyl glucoside of eicosyl docosyl
Glycosides；
C14-22 alcohol/pure and mild eicosyl the glucoside of C12-20 alkyl glucoside+eicosyl docosyl；
Hydrolecithin+arachidic alcohol glucoside；
The assistant for emulsifying agent mass percent is preferably 2%~18%, and more preferably 5%~13%, further preferably 6
~10%；In the specific embodiment of the invention, the mass percent of the emulsifier is 1%, 5%, 2%, 12%, 20%,
10%, 13%, 18% or 7%；
The assistant for emulsifying agent is ceteareth -6, cetostearyl alcohol, hexadecanol, octadecyl alcolol, docosyl alcohol, PEG-
The mixture of one or more of 100 stearates.When the assistant for emulsifying agent is the mixture of many kinds of substance, this hair
The bright ratio to each component in the mixture is not particularly limited；In the specific embodiment of the invention, the assistant for emulsifying agent
Select one of above-mentioned assistant for emulsifying agent, two or three；Such as:
Docosyl alcohol+PEG-100 stearate；Octadecyl alcolol+PEG-100 stearate；Cetostearyl alcohol+docosyl alcohol；16
Octadecyl alcolol+PEG-100 stearate；Cetostearyl alcohol+docosyl alcohol+PEG-100 stearate；Hexadecanol+cetostearyl alcohol+mountain
Yu alcohol；Ceteareth -6+PEG-100 stearate+docosyl alcohol；
The liquid fat mass percent is preferably 8%~30%, and more preferably 10%~25%, further preferably
12~20%；In the specific embodiment of the invention, the mass percent of the liquid fat is 10%, 11%, 25%, 7%,
19%, 5%, 8%, 12%, 13%, 30% or 35%；
The liquid fat is caprylic/capric glyceride, isopropyl myristate, dimethicone, vitamin E, oleic acid
It is ethyl ester, mineral oil, five dimethyl siloxane of polycyclic, pungent capric acid cocoa butter, isononyl isononanoate, isohexadecane, soybean oil, two pungent
The mixture of one or more of capric acid propylene glycol ester, octyl butanol salicylate, sunflower oil, saualane.Work as institute
When stating the mixture that liquid fat is many kinds of substance, the present invention is not particularly limited the ratio of each component in the mixture；
In the specific embodiment of the invention, the liquid fat selects one of above-mentioned liquid fat, two kinds, three kinds or four kinds；
Such as:
Dimethicone+caprylic/capric glyceride+isononyl isononanoate；Five dimethyl siloxane of mineral oil+polycyclic+pungent
Capric acid cocoa butter；Saualane+octyl butanol salicylate+pungent capric acid cocoa butter；Isononyl isononanoate+dimethicone+dimension is raw
Plain E；Isohexadecane+mineral oil+ethyl oleate；Isopropyl myristate+dimethicone；Dimethicone+soybean oil；Diformazan
Base silicone oil+isopropyl myristate+isononyl isononanoate；Sunflower oil+saualane+dimethicone；Two pungent capric acid propylene glycol
Ester+caprylic/capric glyceride+dimethicone；Dimethicone+mineral oil；Mineral oil+saualane+isopropyl myristate+
Five dimethyl siloxane of polycyclic；Isononyl isononanoate+isohexadecane+dimethicone+saualane；
The thickener qualities percentage is preferably 0.05%~4.5%, and more preferably 0.1%~0.4%, it is further excellent
It is selected as 0.2~0.3%；In the specific embodiment of the invention, the mass percent of the thickener is 0.3%, 1.01%,
0.62%, 5%, 2.1%, 0.01%, 0.2%, 0.1%, 0.05%, 0.4%, 0.7% or 4.5%；
The thickener is xanthan gum, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, polyacrylamide
Amine/C13-14 isoparaffin/lauryl alcohol -7, polyvinylpyrrolidone, hypromellose, polyacrylate cross-linked polymeric
The mixture of one or more of object -6, gelatin, Arabic gum, carbomer.When the thickener is many kinds of substance
When mixture, the present invention is not particularly limited the ratio of each component in the mixture；In the specific embodiment of the invention,
The thickener selects one of above-mentioned thickener, two kinds, three kinds or four kinds；Such as:
Polyacrylamide/C13-14 isoparaffin/lauryl alcohol -7+ gelatin；Hydroxy-ethyl acrylate/acryloyldimethyl ox
Sodium sulfonate copolymers+hypromellose；Polyacrylate cross-linked polymer -6+ carbomer；Polyvinylpyrrolidone+propylene
Sour hydroxyl ethyl ester/sodium acryloyldimethyl taurate copolymers；Arabic gum+polyacrylamide/C13-14 isoparaffin/laruyl alcohol
Ether -7+ polyacrylate cross-linked polymer -6；Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers+polyacrylic acid
Ester cross-linked polymer -6；Polyacrylamide/C13-14 isoparaffin/lauryl alcohol -7+ carbomer；Hydroxy-ethyl acrylate/propylene
Acyl dimethyltaurine sodium copolymer+xanthan gum+carbomer；Polyvinylpyrrolidone+different the alkane of polyacrylamide/C13-14
Hydrocarbon/lauryl alcohol -7+ Arabic gum；
The preservative mass percent is preferably 0.2%~9%, more preferably 1%~8%, further preferably 3~
6%；In the specific embodiment of the invention, the mass percent of the preservative is 0.5%, 3%, 3.5%, 9%, 1.3%,
8%, 0.2%, 6%, 1%, 0.1% or 2%；
The preservative is Phenoxyethanol, 1,2- hexylene glycol, 1,2- pentanediol, methyl hydroxybenzoate, ethyl hydroxy benzoate, ethylhexyl
The mixture of one or more of glycerol, decoyl hydroximic acid, parahydroxyacet-ophenone.When the preservative is many kinds of substance
Mixture when, the present invention is not particularly limited the ratio of each component in the mixture；In the specific embodiment of the invention
In, one of described preservative selection foregoing preservatives, two kinds, three kinds or four kinds；Such as:
1,2- hexylene glycol+1,2- pentanediol；Parahydroxyacet-ophenone+1,2- pentanediol；Sensiva SC50+decoyl hydroximic acid
+ 1,2- hexylene glycol；Methyl hydroxybenzoate+ethyl hydroxy benzoate；Sensiva SC50+decoyl hydroximic acid+parahydroxyacet-ophenone；Phenoxyethanol+
Decoyl hydroximic acid+parahydroxyacet-ophenone；Phenoxyethanol+Sensiva SC50；Phenoxyethanol+1,2- hexylene glycol；
In addition, the present invention also provides the preparation methods of the liquid-crystal composition, comprising:
Silybum marianum seed oil, emulsifier, assistant for emulsifying agent, liquid fat are mixed, uniform oily phase is obtained；Radix Ophiopogonis is more
The water of sugar, thickener and surplus is mixed, and obtains uniform water phase；
The oil mutually rapidly joins in the water phase, and emulsification pretreatment processing obtains liquid crystal colostrum；
The liquid crystal colostrum cooling, is added preservative, stirs to get the liquid-crystal composition.
More specifically, the temperature that the silybum marianum seed oil, emulsifier, assistant for emulsifying agent, liquid fat are mixed is preferably
35~80 DEG C, more preferably 40~75 DEG C, further preferably 50~70 DEG C；The time of the mixing is preferably 10~
40min, more preferably 12~35min, further preferably 15~30min；The revolving speed of the mixing is preferably 100~
600rpm, more preferably 150~550rpm, further preferably 200~500rpm.
The temperature that the water of the ophiopogonpolysaccharide, thickener and surplus is mixed is preferably 35~80 DEG C, more preferably 40
~75 DEG C, further preferably 50~70 DEG C；The time of the mixing is preferably 10~40min, more preferably 12~
35min, further preferably 15~30min；The revolving speed of the mixing is preferably 100~600rpm, more preferably 150~
550rpm, further preferably 200~500rpm.
The revolving speed of the emulsification pretreatment processing is preferably 2000~15000rpm, more preferably 4000~12000rpm, into
One step is preferably 8000~10000rpm；The time of the emulsification pretreatment processing is preferably 1~30min, more preferably 5~
25min, further preferably 10~20min.
The temperature of the liquid crystal colostrum cooling is preferably down to 20~60 DEG C, is more preferably down to 25~50 DEG C, further
Preferably it is down to 30~45 DEG C；The time of the stirring is preferably 10~40min, more preferably 12~35min, further preferably
For 15~30min；The revolving speed of the stirring is preferably 100~600rpm, more preferably 150~550rpm, further preferably
200~500rpm.
In the present invention, the emulsifier and assistant for emulsifying agent cooperation, have good mechanism, can be effectively by active group
Divide conveying and penetrate into cuticula makes it effectively play skin so that active component effectively acts on the deep layer cells of skin
Skin is both effectiveness；Compared with the common product of silybum marianum seed oil and ophiopogonpolysaccharide with same amount, skin sense overall merit is more
It is good, feel after there is better appearance, smear and use；With stronger moisture-retaining capacity and oxidation resistance；
Meanwhile each component collaboration increases the stability of liquid-crystal composition；Compared with liquid crystal structure when rigid preparation, this hair
Bright liquid-crystal composition is placed in 45 DEG C, 4 DEG C, the illumination and liquid crystal structure after 2 months and number do not occur significant change under room temperature.
Based on above-mentioned technical effect, the invention proposes the liquid-crystal composition or the liquid crystal prepared by the preparation method
Composition is preparing the application in daily chemical products.Preferably, the daily chemical products are that cosmetics, shower cream or hair-washing hair-care are used
Product, wherein cosmetics include but is not limited to skin care item；The form of the daily chemical products preferably includes cream, emulsion.
From the above technical scheme, the present invention is combined by containing silybum marianum seed oil and ophiopogonpolysaccharide in special material
In the liquid crystal structure of preparation, overall stability is high, and liquid crystal structure is complete；Good closed system can be formed on the skin, increased
The aquation of strong skin, performance of keeping humidity and anti-oxidation efficacy are significant, have a good application prospect in cosmetic field.
Detailed description of the invention
Fig. 1 show liquid-crystal composition liquid crystal structure figure when embodiment 7 is just prepared；
Fig. 2 show 7 liquid-crystal composition of the embodiment of the present invention and is placed in 45 DEG C, 4 DEG C, illumination and under room temperature after 2 months
Liquid crystal structure figure；
Fig. 3 show liquid-crystal composition liquid crystal structure figure when embodiment 11 is just prepared；
Fig. 4 show 11 liquid-crystal composition of the embodiment of the present invention and is placed in 45 DEG C, 4 DEG C, illumination and under room temperature after 2 months
Liquid crystal structure figure；
Fig. 5 show the petrographic microscope figure of liquid crystal cream C1；
Fig. 6 show the petrographic microscope figure of liquid crystal cream C2；
Fig. 7 show skin sensing examination radar map；
Fig. 8 show performance of keeping humidity test column diagram.
Specific embodiment
The invention discloses a kind of anti-oxidant and moisturizing liquid-crystal composition and its preparation method and application, those skilled in the art
Member can use for reference present disclosure, be suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications
Apparent to those skilled in the art, they are considered as being included in the present invention.Liquid crystal combination of the present invention
Object and its preparation method and application is described by embodiment, and related personnel can obviously not depart from the present invention
Hold, liquid-crystal composition described herein and its preparation method and application be modified or suitably changed in spirit and scope and group
It closes, carrys out implementation and application the technology of the present invention.
In the specific embodiment of the invention, it is related to comparative test, each test group is other than due difference, remaining test
Environment and raw material etc. are consistent.
Below just one kind provided by the present invention it is anti-oxidant done with moisturizing liquid-crystal composition and its preparation method and application into
One step explanation.
Embodiment 1: preparation liquid-crystal composition of the present invention
It is 0.5% silybum marianum seed oil, 2% C14-22 alcohol/C12-20 alkyl glucoside, 1% by mass percentage
Hydrolecithin, 1% ceteareth -6,5% dimethicone, 2% caprylic/capric glyceride, 3%
Isononyl isononanoate is stirred 25min under 35 DEG C of water bath condition, with the mixing speed of 300rpm, obtains uniform oil
Phase；
By 0.01% ophiopogonpolysaccharide, 0.1% polyacrylamide/C13-14 isoparaffin/lauryl alcohol -7,0.2%
Gelatin and surplus water mixing, under 35 DEG C of water bath condition, 25min is stirred with the mixing speed of 300rpm, is obtained
Uniform water phase；
Oil is mutually rapidly joined in water phase, 5min is sheared under 4000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 25 DEG C, 0.5% Phenoxyethanol is added, is stirred with the mixing speed of 550rpm
10min obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 2: preparation liquid-crystal composition of the present invention
It is the peanut of 8% silybum marianum seed oil, 4% coco group glucoside and lauric alcohol, 2% by mass percentage
Alcohol glucoside, 1% hydrolecithin, 5% ceteareth -6,1% mineral oil, 5% five dimethyl of polycyclic
Siloxanes, 5% pungent capric acid cocoa butter under 65 DEG C of water bath condition, 30min is stirred with the mixing speed of 200rpm, is obtained
To uniform oily phase；
By 3% ophiopogonpolysaccharide, 1% hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 0.01%
The mixing of the water of hypromellose and surplus, under 65 DEG C of water bath condition, is stirred with the mixing speed of 200rpm
30min obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 20min is sheared under 2000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 45 DEG C, 1.5%1,2- hexylene glycol, 1.5%1,2- pentanediol is added, with stirring for 100rpm
It mixes speed and is stirred 30min, obtain anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 3: preparation liquid-crystal composition of the present invention
It is 1% silybum marianum seed oil, the pure and mild eicosyl Portugal of 6% eicosyl docosyl by mass percentage
The pure and mild coco group glucoside of polyglycoside, 2% PEG-20 methyl sesquistearate, 12% 16 octadecyls, 2%
Cetostearyl alcohol, 10% saualane, 10% octyl butanol salicylate, 5% water of the pungent capric acid cocoa butter at 75 DEG C
Under the conditions of bath, 20min is stirred with the mixing speed of 500rpm, obtains uniform oily phase；
By 0.1% ophiopogonpolysaccharide, the carbomer and surplus of 0.6% polyacrylate cross-linked polymer -6,0.02%
Water mixing, under 75 DEG C of water bath condition, 20min is stirred with the mixing speed of 500rpm, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 2min is sheared under 6000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 40 DEG C, 2% parahydroxyacet-ophenone, 1.5%1,2- pentanediol is added, with stirring for 300rpm
It mixes speed and is stirred 10min, obtain anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 4: preparation liquid-crystal composition of the present invention
By mass percentage be 10% silybum marianum seed oil, 2% stereth -21,3% stereth -
2,9% docosyl alcohol, 3% PEG-100 stearate, 4% isononyl isononanoate, 1% dimethicone, 2% dimension
Raw element E is stirred 30min with the mixing speed of 400rpm, obtains uniform oily phase under 80 DEG C of water bath condition；
By 0.01% ophiopogonpolysaccharide, 2% polyvinylpyrrolidone, 3% hydroxy-ethyl acrylate/acryloyldimethyl
Taurate Copolymer and the mixing of the water of surplus, under 80 DEG C of water bath condition, are stirred with the mixing speed of 400rpm
30min obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 1min is sheared under 12000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 35 DEG C, be added 6% Sensiva SC50,1.5% decoyl hydroximic acid, 1.5%1,2- oneself
Glycol is stirred 15min with the mixing speed of 500rpm, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 5: preparation liquid-crystal composition of the present invention
It is 2% silybum marianum seed oil, the pure and mild 16 octadecyl sugar of 5% 16 octadecyls by mass percentage
Glycosides, the 3% pure and mild eicosyl glucoside of eicosyl docosyl, 12% octadecyl alcolol, 8% PEG-100 it is stearic
Acid esters, 6% isohexadecane, 8% mineral oil, 5% ethyl oleate under 60 DEG C of water bath condition, with the stirring of 100rpm
Speed is stirred 40min, obtains uniform oily phase；
By 0.02% ophiopogonpolysaccharide, 1% Arabic gum, 1% polyacrylamide/C13-14 isoparaffin/laurel
The polyacrylate cross-linked polymer -6 of alcohol ether -7,0.1% and the water mixing of surplus, under 60 DEG C of water bath condition, with
The mixing speed of 100rpm is stirred 40min, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 3min is sheared under 10000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 45 DEG C, 0.5% methyl hydroxybenzoate, 0.8% ethyl hydroxy benzoate is added, with the stirring speed of 300rpm
Degree is stirred 10min, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 6: preparation liquid-crystal composition of the present invention
It is 12% silybum marianum seed oil, the 3% two stearic acid ester of polyglycereol -6,6% eicosyl by mass percentage
The pure and mild eicosyl glucoside of docosyl, 6%C14-22 alcohol/C12-20 alkyl glucoside, 1% cetostearyl alcohol, 2%
Isopropyl myristate, 3% dimethicone under 70 DEG C of water bath condition, be stirred with the mixing speed of 550rpm
40min obtains uniform oily phase；
5% ophiopogonpolysaccharide, 0.01% hypromellose and the water of surplus are mixed, in 70 DEG C of water bath condition
Under, 30min is stirred with the mixing speed of 550rpm, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 25min is sheared under 8000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 50 DEG C, 1% Sensiva SC50,1% decoyl hydroximic acid, 1% para hydroxybenzene second is added
Ketone is stirred 18min with the mixing speed of 600rpm, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 7: preparation liquid-crystal composition of the present invention
It is 15% silybum marianum seed oil, the pure and mild 16 octadecyl sugar of 2% 16 octadecyls by mass percentage
Glycosides, -3 beeswax acid esters of 6% polyglycereol, 1% hydrolecithin, 3% cetostearyl alcohol, 2% docosyl alcohol, 1% dimethicone,
4% soybean oil is stirred 35min under 50 DEG C of water bath condition, with the mixing speed of 600rpm, obtains uniform oily phase；
By 2% ophiopogonpolysaccharide, 0.1% hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 0.1%
Polyacrylate cross-linked polymer -6 and surplus water mixing, under 50 DEG C of water bath condition, with the mixing speed of 600rpm
It is stirred 10min, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 12min is sheared under 6000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 40 DEG C, 2% Phenoxyethanol, 3% decoyl hydroximic acid, 3% parahydroxyacet-ophenone is added, with
The mixing speed of 200rpm is stirred 12min, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 8: preparation liquid-crystal composition of the present invention
Silybum marianum seed oil, the 1% two stearic acid ester of polyglycereol -6,7% eicosyl by mass percentage for 4%
The pure and mild eicosyl glucoside of docosyl, 0.5% C14-22 alcohol/C12-20 alkyl glucoside, the 16 of 5%
Alcohol, 5% PEG-100 stearate, 1% dimethicone, 3% isopropyl myristate, 4% isononyl isononanoate exist
Under 40 DEG C of water bath condition, 15min is stirred with the mixing speed of 500rpm, obtains uniform oily phase；
By 1% ophiopogonpolysaccharide, 0.1% hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers and surplus
Water mixing, under 40 DEG C of water bath condition, 15min is stirred with the mixing speed of 500rpm, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 10min is sheared under 9000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 20 DEG C, 0.2% parahydroxyacet-ophenone is added, it is mixed with the mixing speed stirring of 100rpm
40min is closed, anti-oxidant and moisturizing liquid-crystal composition is obtained.
Embodiment 9: preparation liquid-crystal composition of the present invention
It is 5% silybum marianum seed oil, the pure and mild eicosyl Portugal of 2% eicosyl docosyl by mass percentage
Polyglycoside, 1% pure and mild 16 octadecyl glycosides of 16 octadecyls, 5% cetostearyl alcohol, 5% docosyl alcohol, 3%
PEG-100 stearate, 2% sunflower oil, 5% saualane, 5% dimethicone under 75 DEG C of water bath condition, with
The mixing speed of 400rpm is stirred 40min, obtains uniform oily phase；
By 0.5% ophiopogonpolysaccharide, 0.05% polyacrylamide/C13-14 isoparaffin/lauryl alcohol -7 and surplus
Water mixing, under 75 DEG C of water bath condition, 40min is stirred with the mixing speed of 400rpm, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 30min is sheared under 2000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 30 DEG C, 3% 1,2- pentanediol is added, 3%1,2- hexylene glycols are with the stirring of 100rpm
Speed is stirred 40min, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 10: preparation liquid-crystal composition of the present invention
It is 7% silybum marianum seed oil, 3% C14-22 alcohol/C12-20 alkyl glucoside, 1% by mass percentage
The pure and mild eicosyl glucoside of eicosyl docosyl, 3% hexadecanol, 5% cetostearyl alcohol, 5% docosyl alcohol,
The pungent capric acid propylene glycol ester of the two of 3%, 5% caprylic/capric glyceride, 5% dimethicone under 65 DEG C of water bath condition, with
The mixing speed of 500rpm is stirred 30min, obtains uniform oily phase；
By 0.8% ophiopogonpolysaccharide, 0.2% hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers,
0.2% polyacrylate cross-linked polymer -6 and the mixing of the water of surplus, under 65 DEG C of water bath condition, with the stirring speed of 500rpm
Degree is stirred 30min, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 10min is sheared under 8000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 40 DEG C, 0.5% Phenoxyethanol is added, 0.5% Sensiva SC50 is with 300rpm's
Mixing speed is stirred 20min, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 11: preparation liquid-crystal composition of the present invention
By mass percentage be 4% silybum marianum seed oil, 3% stereth -21,3% stereth -2,
7% ceteareth -6,5% PEG-100 stearate, 6% docosyl alcohol, 4% dimethicone, 3% mine
Object oil is stirred 10min under 80 DEG C of water bath condition, with the mixing speed of 400rpm, obtains uniform oily phase；
By 1% ophiopogonpolysaccharide, 0.1% polyacrylamide/C13-14 isoparaffin/lauryl alcohol -7,0.1% card wave
Nurse and the mixing of the water of surplus, under 35 DEG C of water bath condition, are stirred 12min with the mixing speed of 150rpm, obtain uniform
Water phase；
Oil is mutually rapidly joined in water phase, 2min is sheared under 15000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 20 DEG C, it is mixed with the mixing speed stirring of 150rpm that 0.1% parahydroxyacet-ophenone is added
35min is closed, anti-oxidant and moisturizing liquid-crystal composition is obtained.
Embodiment 12: preparation liquid-crystal composition of the present invention
By mass percentage be 6% silybum marianum seed oil, 1% hydrolecithin, 4% arachidic alcohol glucoside, 7%
Cetostearyl alcohol, 4% mineral oil, 8% saualane, 6% isopropyl myristate, 12% polycyclic, five dimethyl siloxane exist
Under 70 DEG C of water bath condition, 12min is stirred with the mixing speed of 150rpm, obtains uniform oily phase；
By 4% ophiopogonpolysaccharide, 0.5% hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, 0.1%
Xanthan gum, 0.1% carbomer and surplus water mixing, under 70 DEG C of water bath condition, stirred with the mixing speed of 200rpm
Mixing 35min is mixed, uniform water phase is obtained；
Oil is mutually rapidly joined in water phase, 2min is sheared under 15000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 60 DEG C, 1, the 2- hexylene glycol that is added 1%, 2%1,2- pentanediol are with the stirring of 200rpm
Speed is stirred 15min, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 13: preparation liquid-crystal composition of the present invention
It is 2% silybum marianum seed oil, the pure and mild coco group glucoside of 3% 16 octadecyls, 2% by mass percentage
Octadecyl alcolol, 10%% water at 60 DEG C of isononyl isononanoate, 8% isohexadecane, 10% dimethicone, 7% saualane
Under the conditions of bath, 15min is stirred with the mixing speed of 600rpm, obtains uniform oily phase；
By 0.05% ophiopogonpolysaccharide, 2% polyvinylpyrrolidone, the 0.5% different alkane of polyacrylamide/C13-14
Hydrocarbon/lauryl alcohol -7,2% Arabic gum and the water mixing of surplus, under 60 DEG C of water bath condition, with the stirring speed of 600rpm
Degree is stirred 20min, obtains uniform water phase；
Oil is mutually rapidly joined in water phase, 10min is sheared under 6000rpm revolving speed, obtains liquid crystal colostrum；
Liquid crystal colostrum is cooled to 40 DEG C, 0.5% Phenoxyethanol, 1.5%1,2- hexylene glycol is added with the stirring of 200rpm
Speed is stirred 15min, obtains anti-oxidant and moisturizing liquid-crystal composition.
Embodiment 14: stability test
It is test specimens with embodiment 7, embodiment 11, carries out stability test.By 11 gained antioxygen of embodiment 7 and embodiment
Change and moisturizing liquid-crystal composition be respectively placed in 45 DEG C, 4 DEG C, illumination and investigate stability under room temperature, respectively at 1 week, January and
It at 2 months, observes whether it is precipitated and is layered, and its brilliant morphology stability in polarized light microscope observing, the results are shown in Table 1.
The anti-oxidant stability with moisturizing liquid-crystal composition of table 1
As depicted in figs. 1 and 2, the anti-oxidant and moisturizing liquid-crystal composition amplification shot when being 7 stability test of embodiment
Petrographic microscope figure after 100 times.Liquid crystal structure figure when Fig. 1 is just preparation, Fig. 2 liquid-crystal composition are placed in 45 DEG C, 4 DEG C, light
According to and the liquid crystal structure figure after 2 months under room temperature.Comparison diagram 1 and Fig. 2 discovery, liquid crystal number is identical as Fig. 1, and size is equal
One, do not occur significant change, while liquid-crystal composition is also layered without precipitation.
As shown in Figure 3 and Figure 4, the anti-oxidant and moisturizing liquid-crystal composition amplification shot when being 11 stability test of embodiment
Petrographic microscope figure after 100 times.Liquid crystal structure figure when Fig. 3 is just preparation, Fig. 4 liquid-crystal composition are placed in 45 DEG C, 4 DEG C, light
According to and the liquid crystal structure figure after 2 months under room temperature.Comparison diagram 3 and Fig. 4 discovery, liquid crystal number is identical as Fig. 3, and size is equal
One, do not occur significant change, while liquid-crystal composition is also layered without precipitation.
Embodiment 15: skin sensing examination
1, common cream preparation
By mass percentage, firmly by 2.0%PEC-10 dimethyl silicone polymer, 1.0% sucrose stearate, 1.0%
Lipidol, 4.5% glycerin monostearate, 3.0% jojoba oil melt in 75 DEG C of water-baths, obtain oily phase；
By 5.0% glycerol, 5.0% propylene glycol, 0.3% triethanolamine, 0.2% carbomer 2020 and 77.0% purified water in
It is dissolved in 75 DEG C of water-baths, obtains water phase；It is mutually stirred, and emulsifies to get common cream with water phase by oily.
2, the preparation of liquid crystal cream C1 and C2
By above-mentioned common cream and the anti-oxidant and moisturizing liquid-crystal composition of embodiment 7 by 1:1 mix mass fraction is
50.0% is anti-oxidant and the face cream of moisturizing liquid-crystal composition, wherein the ophiopogonpolysaccharide containing mass percent 1%, 7.5% water
Fly Ji seed oil.
The C1 liquid crystal face cream being prepared is amplified 100 times under petrographic microscope, obtains polarized light microscopy as shown in Figure 5
Mirror figure, as shown in figure 5, anti-oxidant and moisturizing face cream liquid crystal size is uniform, effective component is covered by liquid crystal structure.
By above-mentioned common cream and the anti-oxidant and moisturizing liquid-crystal composition of embodiment 11 by 1:1 mix mass fraction is
50.0% is anti-oxidant and the face cream of moisturizing liquid-crystal composition, wherein the ophiopogonpolysaccharide containing mass percent 0.5%, 2% water
Fly Ji seed oil.
The C2 liquid crystal face cream being prepared is amplified 100 times under petrographic microscope, obtains polarized light microscopy as shown in FIG. 6
Mirror figure, as shown in fig. 6, anti-oxidant and moisturizing face cream liquid crystal size is uniform, effective component is covered by liquid crystal structure.
3, the preparation of cream D1 and D2 are compared
By formula and method preparation comparison the cream D1 and D2 without liquid crystal structure in 1:
By mass percentage, by 1% ophiopogonpolysaccharide, 7.5% silybum marianum seed oil, 2.0%PEC-10 poly dimethyl
Siloxanes, 1.0% sucrose stearate, 1.0% stearyl alcohol, 4.5% glycerin monostearate, 3.0% jojoba oil are in 75 DEG C
It is melted in water-bath, obtains oily phase；
By 5.0% glycerol, 5.0% propylene glycol, 0.3% triethanolamine, 0.2% carbomer 2020 and 69.5% purified water in
It is dissolved in 75 DEG C of water-baths, obtains water phase；It is mutually stirred, and emulsifies to get anti-oxidant without liquid crystal structure with water phase by oily
Cream D1 is compared with moisturizing.
The comparison cream is identical as ophiopogonpolysaccharide, the silybum marianum seed oil content in liquid crystal cream C1, and use with 1 in phase
Same basic cream ingredient, difference are not contain ophiopogonpolysaccharide, silybum marianum seed oil with liquid crystal structure.
By mass percentage, by 0.5% ophiopogonpolysaccharide, 2% silybum marianum seed oil, 2.0%PEC-10 poly dimethyl
Siloxanes, 1.0% sucrose stearate, 1.0% stearyl alcohol, 4.5% glycerin monostearate, 3.0% jojoba oil are in 75 DEG C
It is melted in water-bath, obtains oily phase；
By 5.0% glycerol, 5.0% propylene glycol, 0.3% triethanolamine, 0.2% carbomer 2020 and 75.5% purified water in
It is dissolved in 75 DEG C of water-baths, obtains water phase；It is mutually stirred, and emulsifies to get anti-oxidant without liquid crystal structure with water phase by oily
Cream D2 is compared with moisturizing.
The comparison cream is identical as ophiopogonpolysaccharide, the silybum marianum seed oil content in liquid crystal cream C2, and use with 1 in phase
Same basic cream ingredient, difference are not contain ophiopogonpolysaccharide, silybum marianum seed oil with liquid crystal structure.
4, skin sensing examination
The skin sense of above-mentioned liquid crystal cream and comparison cream is tested, comparison is without liquid-crystal composition of the present invention and contains
The skin sense difference of the anti-oxidant and moisturizing face cream of liquid-crystal composition of the present invention.
20 sensory evaluation persons are chosen, the age is between 20~50 years old.
I, sensory evaluation person prepares
(1) 5h is interior without using any skin care item before testing for valuation officer's hand and face.
(2) valuation officer sits quietly 30min in the environment that humidity is (50 ± 10) % and temperature is (22 ± 1) DEG C, at this section
Between be familiar with sensory evaluation criteria and evaluation questionnaire.Sensory evaluation standards of grading are shown in Table 2.
II, sensory evaluation step
(1) valuation officer using appropriate mildly without fragrant amino acid cleansing cream arm of cleaning and face, wherein rinse arm 1min,
Hand is from tap 3cm, after rinsing well, dries face and hand moisture using no fragrant paper towel.
(2) unified to enter sensory evaluation laboratory, use the slide calliper rule positioning plate of 5cm × 5cm respectively in valuation officer two after 2min
A inboard arm marks at wrist 5cm.
(3) begin to use skin care item after 2min, 0.2mL sample is applied to inboard arm mark zone with syringe (removing syringe needle)
Domain.
(4) it is looped smearing with finger pulp with the speed of 1~2r/min, smears sensory experience when contrast sample after 3 circles applies step
Carry out assessment marking.
(5) after smearing 11 circles, lotion is promoted to absorb by way of beating, after absorption, comparison reference sample reevaluates phase
Close performance.
2 cosmetics sensory evaluation index of table summarizes
3 sensory evaluation record sheet of table
Radar map is drawn by the Analyses Methods for Sensory Evaluation Results of table 3, can clearly find out from Fig. 7 skin sense radar map, contain this hair
The anti-oxidant and moisturizing face cream skin sense overall merit of bright liquid-crystal composition compared with do not include liquid-crystal composition of the present invention it is good, with compared with
Feel after appearance well, smear and use.
Embodiment 16: performance of keeping humidity test
Using the liquid crystal cream in embodiment 15 and cream is compared as test specimens, and comparison is without liquid-crystal composition of the present invention and contains
There is the performance of keeping humidity difference of the anti-oxidant and moisturizing face cream of liquid-crystal composition of the present invention.
Moisture content using capacitance method measurement human skin keratinocyte's layer is the D-value of dielectric constant based on water He other substances
Different significant, according to the difference of keratoderma moisture content, the capacitance of the skin measured is different, and parameter can represent skin water
Divide content.
30 testers are chosen, test 19.0 DEG C of environment temperature, humidity 44.5%.Select the left and right inboard arm of subject
Away from being experiment position at palm base portion 5cm, test area is 3 × 3cm2, laboratory sample amount is 0.05mL, in each subject
Left and right inboard arm experiment position uniformly smears sample, and record smears the time, is smearing sample 15min, 30min, 1h, 2h,
4h, 6h test moisture content with the skin moisture content measuring instrument CM825 that German CK company produces, and measurement is measured in parallel 3 every time
It is secondary, it is averaged.Count each numerical value of subject's experiment position, the changing rule of analysis moisture content.
From figure 8, it is seen that the skin moisture content of liquid crystal cream is obviously higher than comparison cream in the 6h testing time, say
The bright cream containing liquid-crystal composition of the present invention has stronger moisture-retaining capacity than the cream without liquid-crystal composition of the present invention, more can
Play the function of ophiopogonpolysaccharide and silybum marianum seed oil.
Embodiment 17: antioxygenic property test
Using the liquid crystal cream in embodiment 15 and cream is compared as test specimens, carries out anti-oxidation efficacy experiment.
The antioxidation in vitro performance that sample is evaluated with the method for removing DPPH free radical, when with the presence of free radical scavenger
When, and its electron pairing makes UV absorption remitted its fury even disappear, and to it to receive electron amount directly proportional for fading extent.
Therefore, the antioxidant activity of sample can be evaluated by the variation of measurement light absorption value.
The ethanol solution and 2.0mL that 4.0mL (0.02mg/mL) DPPH is sequentially added in 10mL colorimetric cylinder are respectively tested
Sample dehydrated alcohol dilution (3mg/mL) adds dehydrated alcohol to scale, mix immediately 1cm cuvette in 517nm wavelength
Place surveys light absorption value (A), and light absorption value is denoted as Ai, and room temperature surveys light absorption value after 30min is kept in dark place, and is denoted as Aj, and check experiment is only to add
The ethanol solution of DPPH, light absorption value are denoted as Ac.Free radical scavenging activity (K) is calculated as follows:
K (%)=[1- (Ai-Aj)/Ac] × 100%
Using liquid crystal cream and comparison cream as experimental group, free radical scavenging activity is detected, measurement three times, is averaged, and is tested
The result is as follows:
The experiment of 4 anti-oxidation efficacy of table
| Sample | K (%) |
| Liquid crystal cream C1 | 75.8 |
| Compare cream D1 | 63.2 |
| Liquid crystal cream C2 | 74.3 |
| Compare cream D2 | 61.5 |
As shown in Table 4, provided by the invention anti-oxidant and moisturizing liquid-crystal composition face cream is high to the clearance rate of free radical,
Relatively without liquid-crystal composition of the present invention anti-oxidant and moisturizing face cream resistance free radical effect it is more significant, improve 12% with
On, it can more play the function of ophiopogonpolysaccharide and silybum marianum seed oil.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of anti-oxidant and moisturizing liquid-crystal composition, which is characterized in that including 0.01~5% ophiopogonpolysaccharide, silybum marianum seed oil
0.5~15%, emulsifier 1~20%, assistant for emulsifying agent 1~20%, liquid fat 5~35%, thickener 0.01~5%, anti-corrosion
Agent 0.1~10%, surplus are water.
2. liquid-crystal composition according to claim 1, which is characterized in that including 0.05~4% ophiopogonpolysaccharide, silybum marianum seed oil
1%~12%, emulsifier 3%~18%, assistant for emulsifying agent 2%~18%, liquid fat 8%~30%, thickener 0.05%~
4.5%, preservative 0.2~9%, surplus is water.
3. liquid-crystal composition according to claim 2, which is characterized in that including 0.1~2% ophiopogonpolysaccharide, silybum marianum seed oil
2%~10%, emulsifier 5%~15%, assistant for emulsifying agent 5%~13%, liquid fat 10%~25%, thickener 0.1%~
0.4%, preservative 1~8%, surplus is water.
4. liquid-crystal composition according to claim 1 to 3, which is characterized in that the emulsifier is PEG-20 methyl
Glucose sesquistearate, stereth -21, stereth -2, the two stearic acid ester of polyglycereol -6, polyglycereol -3 beeswax acid
Ester, C14-22 alcohol/C12-20 alkyl glucoside, arachidic alcohol glucoside, pure and mild 16 octadecyl glycosides of 16 octadecyls, two
The pure and mild eicosyl glucoside of ten alkyl docosyls, coco group glucoside and lauric alcohol, 16 octadecyls are pure and mild
The mixture of one or more of coco group glucoside, hydrolecithin.
5. liquid-crystal composition according to claim 1 to 3, which is characterized in that the assistant for emulsifying agent is cetearyl alcohol
One or more of alcohol polyethers -6, cetostearyl alcohol, hexadecanol, octadecyl alcolol, docosyl alcohol, PEG-100 stearate
Mixture.
6. liquid-crystal composition according to claim 1 to 3, which is characterized in that the liquid fat is octanoic acid/last of the ten Heavenly stems
Acid glyceride, isopropyl myristate, dimethicone, vitamin E, ethyl oleate, mineral oil, five dimethyl silica of polycyclic
Alkane, pungent capric acid cocoa butter, isononyl isononanoate, isohexadecane, soybean oil, two pungent capric acid propylene glycol esters, octyl butanol salicylic acid
The mixture of one or more of ester, sunflower oil, saualane.
7. liquid-crystal composition according to claim 1 to 3, which is characterized in that the thickener is xanthan gum, third
Olefin(e) acid hydroxyl ethyl ester/sodium acryloyldimethyl taurate copolymers, polyacrylamide/C13-14 isoparaffin/lauryl alcohol -7 gather
Vinylpyrrolidone, hypromellose, polyacrylate cross-linked polymer -6, gelatin, Arabic gum, one in carbomer
Kind or two or more mixtures.
8. liquid-crystal composition according to claim 1 to 3, which is characterized in that the preservative be Phenoxyethanol,
1,2- hexylene glycol, 1,2- pentanediol, methyl hydroxybenzoate, ethyl hydroxy benzoate, Sensiva SC50, decoyl hydroximic acid, parahydroxyacet-ophenone
One or more of mixture.
9. the preparation method of liquid-crystal composition described in claim 1 characterized by comprising
Silybum marianum seed oil, emulsifier, assistant for emulsifying agent, liquid fat are mixed, uniform oily phase is obtained；By ophiopogonpolysaccharide,
Thickener and the water of surplus are mixed, and obtain uniform water phase；
The oil mutually rapidly joins in the water phase, and emulsification pretreatment processing obtains liquid crystal colostrum；
The liquid crystal colostrum cooling, is added preservative, stirs to get the liquid-crystal composition.
10. the liquid crystal combination of preparation method preparation described in any one of claim 1~7 liquid-crystal composition or claim 8
Object is preparing the application in daily chemical products.
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| CN114344185B (en) * | 2021-12-09 | 2023-09-26 | 武汉中科光谷绿色生物技术有限公司 | Oil-in-water skin care emulsion containing sialic acid salt and preparation method thereof |
| CN115177551A (en) * | 2022-08-19 | 2022-10-14 | 广州陶妆生物科技有限公司 | Cosmetic additive |
| CN115804737A (en) * | 2022-12-15 | 2023-03-17 | 诺斯贝尔化妆品股份有限公司 | Moisturizing cream with lamellar liquid crystal structure, preparation method and application |
| CN115804737B (en) * | 2022-12-15 | 2024-06-18 | 诺斯贝尔化妆品股份有限公司 | Moisturizing cream with lamellar liquid crystal structure, preparation method and application |
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