CN109331080A - The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection - Google Patents
The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection Download PDFInfo
- Publication number
- CN109331080A CN109331080A CN201811301692.8A CN201811301692A CN109331080A CN 109331080 A CN109331080 A CN 109331080A CN 201811301692 A CN201811301692 A CN 201811301692A CN 109331080 A CN109331080 A CN 109331080A
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- pharmaceutical composition
- borneol
- menthol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection, the composition contains following drug: honeysuckle, wild chrysanthemum, cordate houttuynia, radix bupleuri, menthol, borneol, eucalyptus oil.Pharmaceutical composition all medicines share provided by the invention has effects that inducing diaphoresis heresy, throat, dispelling wind heat, and sample is simultaneously controlled, and tonification and purgation in combination, curative for effect.The present invention is used for acute upper respiratory infection, abscess of throat and bronchial asthma, has significant curative effect to diseases such as chronic bronchitis, acute and chronic bronchitis asthma.
Description
Technical field
The present invention relates to a kind of pharmaceutical compositions and preparation method thereof for treating acute upper respiratory infection.
Background technique
The usual infection of the upper respiratory tract refers to the general name from nasal cavity to the acute inflammation between throat, is the most common breathing system
System disease can betide the crowd at any age, and mostly season in spring and autumn is fallen ill.The disease belongs to respiratory tract infection scope.If treatment
Not in time, easily cause tracheae and pulmonary infection, the tablet of conventional pharynx-clearing throat-benefiting sometimes can only respite pain symptom,
But it fundamentally can't resolve illness that is clearing heat and detoxicating, removing stasis.
That therefore, it is necessary to develop a kind of components is simple, production is simple, can multi-form medication, good effect and have no toxic side effect
Chinese medicine composition.Achieve the purpose that quality-high and inexpensive economic and practical.
Summary of the invention
It is an object of the present invention to provide a kind of pharmaceutical compositions and preparation method thereof for treating acute upper respiratory infection.
Realize that the technical solution of the object of the invention is as follows:
A kind of pharmaceutical composition for treating acute upper respiratory infection contains following drug: honeysuckle, wild chrysanthemum, fish raw meat
Grass, radix bupleuri, menthol, borneol, eucalyptus oil.
Preferably, described pharmaceutical composition contains the drug of following parts by weight: 100-150 parts of honeysuckle, wild chrysanthemum 100-
150 parts, 100-150 parts of cordate houttuynia, 100-150 parts of radix bupleuri, 0.5-1.5 parts of menthol, 0.1-0.9 parts of borneol, 1-3 parts of eucalyptus oil.
It is further preferred that described pharmaceutical composition contains the drug of following parts by weight: 110-135 parts of honeysuckle, mother chrysanthemum
110-135 parts of flower, 110-135 parts of cordate houttuynia, 110-135 parts of radix bupleuri, 0.8-1.2 parts of menthol, 0.3-0.7 parts of borneol, eucalyptus oil
1.5-2.5 part.
It is further preferred that described pharmaceutical composition contains the drug of following parts by weight: 125 parts of honeysuckle, wild chrysanthemum
125 parts, 125 parts of cordate houttuynia, 125 parts of radix bupleuri, 1 part of menthol, 0.5 part of borneol, 2 parts of eucalyptus oil.
The above-mentioned eucalyptus oil of the present invention is myrtle blue gum Eucalyptus globulus LabilL., lauraceae plant
Two section of camphor tree Cinnamomum camphora (L.) Presl or above-mentioned belongs to the volatile oil that other plant is extracted through steam distillation,
Meet States Pharmacopoeia specifications.
Parts by weight of the present invention can be the unit of weight well known in the art such as μ g, mg, g, kg, be also possible to it again
Number, such as 1/10,1/100,10 times, 100 times.
The present invention also provides the preparation methods of aforementioned pharmaceutical compositions, comprising the following steps: takes drug according to the ratio；By gold and silver
Flower, wild chrysanthemum, cordate houttuynia, radix bupleuri carry out steam distillation after adding suitable quantity of water to impregnate, collect distillate；Menthol, borneol are used
Ethanol in proper amount dissolution, adds eucalyptus oil, mixing is sufficiently stirred, be added in above-mentioned distillate, add when stirring, and mixes, filtering, i.e.,
?.
The present invention also provides the preparation containing aforementioned pharmaceutical compositions, said preparation is by described pharmaceutical composition and pharmaceutically may be used
The carrier of receiving forms.
The pharmaceutically acceptable carrier includes one or more of purified water, distilled water, ethyl alcohol, Tween-80 etc..
The preparation is preferably spray, aerosol, solution, mixture etc..
The present invention also provides the methods for preparing above-mentioned preparation, method includes the following steps: by described pharmaceutical composition
It is uniformly mixed with carrier, is made according to a conventional method.
It is further preferred that the preparation is spray, it is made of the ingredient for including following parts by weight: 125 parts of honeysuckle,
125 parts of wild chrysanthemum, 125 parts of cordate houttuynia, 125 parts of radix bupleuri, 1 part of menthol, 0.5 part of borneol, 2 parts of eucalyptus oil.
Preferably, the preparation method of the spray the following steps are included: take drug according to the ratio；By honeysuckle, wild chrysanthemum,
Cordate houttuynia, radix bupleuri carry out steam distillation after adding suitable quantity of water to impregnate, collect distillate；Menthol, borneol ethanol in proper amount is molten
Solution, adds eucalyptus oil and appropriate Tween-80, mixing is sufficiently stirred, be added in above-mentioned distillate, add when stirring, and mixes, mistake
Filter to get being made 1000 parts altogether.
Preferably, the soaking time is 2-6 hours.
Further, every 1mL preparation is equivalent to crude drug 0.5g.
The present invention also provides aforementioned pharmaceutical compositions or preparation in the drug of preparation treatment acute upper respiratory infection
Application.
Pharmaceutical composition of the present invention or preparation inducing diaphoresis heresy, throat, dispelling wind heat.It is particularly suitable for treating on acute and exhale
Inhale road infection, abscess of throat.
The invention has the advantages that:
Throat is belonging to lung stomach, and wind-heat poison heresy follows mouth and nose and invades lung stomach, and throat stands in the breach, and the evil knot of poison is in throat, train of thought
It is impaired, it mutually wins and does not go, therefore abscess of throat, belong to Chinese medicine anemopyretic tonsillitis or anemopyretic laryngalgia scope.Pharmaceutical composition provided by the invention
In object, with honeysuckle, chrysanthemum, cordate houttuynia it is clearing heat and detoxicating based on, be monarch drug in a prescription；Radix bupleuri inducing diaphoresis is thoroughly evil, and principal drug assistance inducing diaphoresis is diathermanous, is minister
Medicine；Menthol makees excitants, acts on skin or mucous membrane, has refrigerant antipruritic, wind dispelling to relieve pain, promote blood circulation, mitigate edema
Deng, borneol resuscitation with aromatics, dispelling wind and heat from the body, the refrigerant bactericidal effect of eucalyptus oil, help medicine-feeding expelling wind to resolve the exterior, reducing pharyngeal swelling of having one's ideas straightened out, be adjutant.
Cordate houttuynia is pungent, slightly cold, distributed in lung channel, except clearing heat and detoxicating in addition to monarch drug in a prescription, it is main enter lung channel, be apt to clearing lung-heat heat, draw all medicines and act on heat-clearing solution
Poison, the carbuncle that disappears apocenosis, and to make medicine.Inducing diaphoresis heresy, throat, dispelling wind heat are played altogether in full side.For acute upper respiratory infection, throat is swollen
Bitterly.
All medicines share of the present invention has effects that inducing diaphoresis heresy, throat, dispelling wind heat, and sample is simultaneously controlled, and tonification and purgation in combination, curative effect
Definitely.The present invention is used for acute upper respiratory infection, abscess of throat and bronchial asthma, to chronic bronchitis, acute and chronic branch
The diseases such as san bronchial asthma have significant curative effect.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..It is not specified in embodiment specific
Technology or conditions person, described technology or conditions according to the literature in the art, or carried out according to product description.It is used
Production firm person is not specified in reagent or instrument, is the conventional products that can be commercially available by regular distributor.
Embodiment 1
A kind of pharmaceutical composition (spray) for treating acute upper respiratory infection, is made: honeysuckle of ingredient below
125g, wild chrysanthemum 125g, cordate houttuynia 125g, radix bupleuri 125g, menthol 1g, borneol 0.5g, eucalyptus oil 2mL.
Every 1mL spray is equivalent to crude drug 0.5g.
Preparation method includes: to take above seven taste according to the ratio, adds appropriate amount of water to impregnate honeysuckle, wild chrysanthemum, cordate houttuynia, radix bupleuri
Steam distillation is carried out after 4 hours, collects distillate about 800mL, it is spare.Menthol, borneol are dissolved with ethanol in proper amount, then divided
Not Jia Ru eucalyptus oil and appropriate Tween-80, mixing is sufficiently stirred；Then, it is added in above-mentioned distillate while stirring, mixes, filtering,
Spray 1000mL is made, dispenses to obtain the final product.
Embodiment 2
A kind of pharmaceutical composition (spray) for treating acute upper respiratory infection, is made: honeysuckle of following component
120g, wild chrysanthemum 120g, cordate houttuynia 120g, radix bupleuri 120g, menthol 1g, borneol 0.5g, eucalyptus oil 2ml.
Preparation method is same as Example 1.
Embodiment 3
A kind of pharmaceutical composition (spray) for treating acute upper respiratory infection, is made: honeysuckle of following component
130g, wild chrysanthemum 130g, cordate houttuynia 130g, radix bupleuri 130g, menthol 1g, borneol 0.5g, eucalyptus oil 2ml.
Preparation method is same as Example 1.
Embodiment 4
A kind of pharmaceutical composition (spray) for treating acute upper respiratory infection, is made: honeysuckle of following component
110g, wild chrysanthemum 110g, cordate houttuynia 110g, radix bupleuri 110g, menthol 1g, borneol 0.5g, eucalyptus oil 2ml.
Preparation method is same as Example 1.
Embodiment 5
A kind of pharmaceutical composition (spray) for treating acute upper respiratory infection, is made: honeysuckle of following component
125g, wild chrysanthemum 125g, cordate houttuynia 125g, radix bupleuri 125g, menthol 0.9g, borneol 0.5g, eucalyptus oil 3ml.
Preparation method is same as Example 1.
Comparative example 1
Pharmaceutical composition (spray), is made of following component: wild chrysanthemum 125g, radix bupleuri 125g, menthol 1g, borneol
0.5g, eucalyptus oil 2mL.Preparation method is (difference is only that raw material does not include honeysuckle and cordate houttuynia) same as Example 1.
Experimental example 1
Laboratory sample: the pharmaceutical composition (spray) for the treatment of acute upper respiratory infection prepared by embodiment 1；
Control sample 1: pharmaceutical composition (spray) prepared by comparative example 1；
Control sample 2: ice connects Qingyan Spray, and (component is rheum officinale, boron to Chenzhou Sanjiu Medical & Pharmaceutical Co., Ltd.'s production
Sand, indigo naturalis, borneol, menthol, saltcake, the coptis, honeysuckle, turmeric, Radix Glycyrrhizae).
Experimental method:
207 medical patients are chosen, patient has different degrees of bottleneck throat pain itch, dry, cough and expectoration, foreign matter
The symptoms such as sense, phonopathy, wherein male 105, women 102；Year at age (35.74 ± 14.61).It is randomly divided into control group
1 (using control sample 1, oral cavity injection, spray 3 times is pressed in sucking on the 1st, and one time 1-2 is pressed, and is used in conjunction 5), control group 2 (use control
Sample 2, one time 5 spray, 6 times a day, the course for the treatment of be 5 days), test group (use example 1 drug composition, oral cavity injection, sucking,
Spray 3 times is pressed within 1st, one time 1-2 is pressed, and is used in conjunction 5), every group of 69 people.
Gender, age, severity extent are statistically analyzed respectively, and there was no significant difference.Tobacco and wine are disabled during treatment
With pungent stimulation food.
Curative effect judging standard is drafted according to " new Chinese medicine guideline of clinical investigations ".Cure: symptom mitigates in 3d, fills
Blood, swelling disappear, no abnormalities feel；Effective: symptom and sign improves in 3d；Effective: symptom and sign improves in treatment 3-5d；Nothing
Effect: symptom and sign is without improvement in treatment 5d.Experimental result see the table below.
As the result is shown: 1 treated effect of control group is only 78.3%, and the effective percentage of control group 2 is 89.8%, and experimental group has
Efficiency is 92.8%；Show that experimental group cure rate is significantly larger than other groups, inefficiency is also lower with respect to other, and has conspicuousness
Difference.It can be seen that the present invention is in terms for the treatment of acute upper respiratory infection, abscess of throat, effect is better than the prior art.
Experimental example 2
The pharmaceutical composition (spray) prepared with embodiment 1 carries out 472 patients in 6 months for laboratory sample
Treatment.
Treatment method: oral cavity injection, sucking press spray 3 times on the 1st, press for one time 1~2, be used in conjunction 5.
Effect standard:
Recovery from illness: abscess of throat symptom disappears, and upper respiratory tract infection symptoms disappear；
Effective: abscess of throat symptom disappears, upper respiratory tract mild infection；
Effective: abscess of throat, upper respiratory tract infection symptoms slightly mitigate；
Invalid: abscess of throat, upper respiratory tract infection symptoms mitigate, and do not change.
Through counting, as a result are as follows: effective 176, account for the 37.3% of total patient；Effective 148, account for the 31.4% of total patient；
The patient of recovery from illness is 145, accounts for the 30.7% of total patient；Invalid 3, the 0.6% of total patient, in effective and effective case
Only 2 are not cured；Total effective rate is 99.4%.
Typical case:
1, Huang, male, 20 years old, on June 11st, 2017 symptoms include fever and headache were had sore throat, the sliding number of pulse condition and float, tongue fur
Bao Bai, tongue body side point is red, and tonsillotome is red and swollen.Doctor suggests making using this product (medicinal composition spray prepared by embodiment 1)
After 2 days, symptom is obviously improved, and is fully recovered after 5 days.
2, certain is thanked, female 21 years old, facilitates outpatient clinic, main suit's dysphagia on May 28th, 2017 to our hospital, throat itches,
Swelling and pain, fried chicken was eaten before 2 days, every other day again eaten pineapple and ice watermelon, diagnosis is acute upper respiratory infection, after issue
This product (medicinal composition spray prepared by embodiment 1), began to use, symptom is alleviated within second day, disease after 3 days in the same day
Shape thoroughly disappears；
3, Lee, male, 35 years old, on April 5th, 2012 examined, and main suit generated heat 37.5 DEG C from yesterday, and nasal obstruction flows yellow tears, had a headache, pharynx
Larynx swelling and pain, red tip of tongue, moss thin yellow, superficial and rapid pulse.Doctor is recommended to use this product (medicinal composition spray prepared by embodiment 1),
After 2 days, illness disappears.
It is attached: spray quality standard of the present invention
[character] this product is milky emulsion liquid or colourless clear liquid, has special aroma.
[identification] takes this product as test solution.Borneol reference substance separately is taken, adds ethyl acetate that every 1ml is made containing 1mg's
Solution, as reference substance solution.It is tested according to thin-layered chromatography (" Chinese Pharmacopoeia "), draws this product and each 5 μ l of reference substance solution, point
Other point is on the same silica gel g thin-layer plate using sodium carboxymethylcellulose as binder, with petroleum ether (60~90 DEG C)-acetic acid second
Ester-benzene (9: 1: 2) is solvent, is unfolded, and takes out, dries, and it is aobvious to be heated to spot at 105 DEG C with 10% phosphomolybdic acid ethanol for spray
Color is clear.In sample chromatogram, on reference substance chromatography corresponding position, identical blue spot should be shown.
[inspection] should meet related every regulation under " Chinese Pharmacopoeia " spray item.
[major function] inducing diaphoresis heresy, throat, dispelling wind heat.For abscess of throat；Above-mentioned card is shown in acute upper respiratory infection
Hou Zhe.
The injection of [usage and dosage] oral cavity, sucking.Spray 3 times is pressed within 1st, presses, or follows the doctor's advice for one time 1~2.
[specification] every 1ml is equivalent to medicine materical crude slice 0.5g.
[storage] is closed, sets cool dark place.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of pharmaceutical composition for treating acute upper respiratory infection, which is characterized in that contain following drug: honeysuckle, it is wild
Chrysanthemum, cordate houttuynia, radix bupleuri, menthol, borneol, eucalyptus oil.
2. pharmaceutical composition according to claim 1, which is characterized in that the drug containing following parts by weight: honeysuckle
100-150 parts, 100-150 parts of wild chrysanthemum, 100-150 parts of cordate houttuynia, 100-150 parts of radix bupleuri, 0.5-1.5 parts of menthol, borneol
0.1-0.9 parts, 1-3 parts of eucalyptus oil.
3. pharmaceutical composition according to claim 1, which is characterized in that the drug containing following parts by weight: honeysuckle
110-135 parts, 110-135 parts of wild chrysanthemum, 110-135 parts of cordate houttuynia, 110-135 parts of radix bupleuri, 0.8-1.2 parts of menthol, borneol
0.3-0.7 parts, 1.5-2.5 parts of eucalyptus oil.
4. pharmaceutical composition according to claim 1, which is characterized in that the drug containing following parts by weight: honeysuckle 125
Part, 125 parts of wild chrysanthemum, 125 parts of cordate houttuynia, 125 parts of radix bupleuri, 1 part of menthol, 0.5 part of borneol, 2 parts of eucalyptus oil.
5. the preparation method of any one of claim 1-4 described pharmaceutical composition, which comprises the following steps: by matching
Than taking drug；Steam distillation is carried out after adding suitable quantity of water to impregnate honeysuckle, wild chrysanthemum, cordate houttuynia, radix bupleuri, collects distillate；
Menthol, borneol are dissolved with ethanol in proper amount, eucalyptus oil is added, mixing is sufficiently stirred, be added in above-mentioned distillate, when stirring
Add, mix, filtering to get.
6. the preparation of the described in any item pharmaceutical compositions of 1-4 containing claim, said preparation is by pharmaceutical composition and pharmaceutically may be used
The carrier of receiving forms.
7. preparation according to claim 6, which is characterized in that the preparation is spray, aerosol, solution or conjunction
Agent.
8. preparation according to claim 7, which is characterized in that the preparation is spray, by including following parts by weight
Ingredient is made: 125 parts of honeysuckle, 125 parts of wild chrysanthemum, and 125 parts of cordate houttuynia, 125 parts of radix bupleuri, 1 part of menthol, 0.5 part of borneol, eucalyptus
2 parts of oil；Preferably, every 1mL spray is equivalent to crude drug 0.5g.
9. the preparation method of preparation described in claim 8, which comprises the following steps: take drug according to the ratio；By gold and silver
Flower, wild chrysanthemum, cordate houttuynia, radix bupleuri carry out steam distillation after adding suitable quantity of water to impregnate, collect distillate；Menthol, borneol are used
Ethanol in proper amount dissolution, adds eucalyptus oil and appropriate Tween-80, mixing is sufficiently stirred, be added in above-mentioned distillate, when stirring
Add, mix, filters to get 1000 parts are made altogether.
10. the described in any item pharmaceutical compositions of claim 1-4 or claim 5 the method preparation pharmaceutical composition or
The described in any item preparations of claim 6-8 or the preparation of claim 9 the method preparation are in the acute upper breathing of preparation treatment
Application in the drug of road infection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811301692.8A CN109331080A (en) | 2018-11-02 | 2018-11-02 | The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811301692.8A CN109331080A (en) | 2018-11-02 | 2018-11-02 | The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109331080A true CN109331080A (en) | 2019-02-15 |
Family
ID=65313457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811301692.8A Pending CN109331080A (en) | 2018-11-02 | 2018-11-02 | The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109331080A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615923A (en) * | 2003-11-12 | 2005-05-18 | 成都三明药物研究所 | Medicinal composition and its preparing method and use |
| CN1857343A (en) * | 2006-04-11 | 2006-11-08 | 徐蕾 | Chinese medicine composition for preventing and treating viral cold and throat disease and its preparing method |
| CN102512533A (en) * | 2011-12-16 | 2012-06-27 | 曲靖开发区格力康生物科技发展有限公司 | Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof |
| CN104666431A (en) * | 2015-02-16 | 2015-06-03 | 广西双蚁药业有限公司 | Traditional Chinese medicine preparation for treating acute upper respiratory tract infection and production method of traditional Chinese medicine preparation |
-
2018
- 2018-11-02 CN CN201811301692.8A patent/CN109331080A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615923A (en) * | 2003-11-12 | 2005-05-18 | 成都三明药物研究所 | Medicinal composition and its preparing method and use |
| CN1857343A (en) * | 2006-04-11 | 2006-11-08 | 徐蕾 | Chinese medicine composition for preventing and treating viral cold and throat disease and its preparing method |
| CN102512533A (en) * | 2011-12-16 | 2012-06-27 | 曲靖开发区格力康生物科技发展有限公司 | Traditional Chinese medicine composition for treating swelling and pain in throat and preparation thereof |
| CN104666431A (en) * | 2015-02-16 | 2015-06-03 | 广西双蚁药业有限公司 | Traditional Chinese medicine preparation for treating acute upper respiratory tract infection and production method of traditional Chinese medicine preparation |
Non-Patent Citations (1)
| Title |
|---|
| 罗斌等: "中药经皮给药佐治小儿肺炎1624例临床观察 ", 《儿科药学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102319294B (en) | Double-vanilla preparation and preparation method thereof | |
| CN106421039A (en) | Traditional Chinese medicine composition for preventing and treating haze-caused diseases, preparation method thereof and mask containing traditional Chinese medicine | |
| CN101584810B (en) | Medicine composition for treating gastritis and peptic ulcer and preparation method thereof | |
| CN101537055A (en) | Swine enzootic pneumonia treatment recipe, preparation method and liquid medicine using method | |
| CN102362965A (en) | Formula with sounding effect and preparation method thereof | |
| CN101843682A (en) | Maxingshigan injecta and preparation method thereof | |
| CN100534526C (en) | Chinese medicine for treating respiratory disease | |
| CN113995821B (en) | Chinese medicinal composition for treating pneumonia caused by novel coronavirus and other viruses, preparation and preparation method thereof | |
| CN109331080A (en) | The pharmaceutical composition and preparation method thereof for treating acute upper respiratory infection | |
| CN105412281A (en) | Traditional Chinese medicinal composition for treating allergic asthma and preparation method thereof | |
| CN105832848A (en) | Traditional Chinese medicine composition for poultry respiratory diseases and preparation method thereof | |
| CN104958727B (en) | A kind of Chinese medicine composition for treating the childhood asthma paracmasis and its application | |
| CN104740581B (en) | A kind of application of cold asthma patch of fragrant fiber crops and its detection method | |
| CN1025478C (en) | Nose liniment and preparing process | |
| JP5265347B2 (en) | Use of konjac and its extract in formulating pharmaceuticals for the treatment of acute and chronic bronchitis | |
| CN110585281B (en) | Children and adults common traditional Chinese medicine preparation for treating phlegm-heat obstructing lung and preparation method thereof | |
| CN104127544B (en) | The application in preparing medicine of Murraya tetramera Huang and extract thereof | |
| CN102908607A (en) | External traditional Chinese medicine for treating chronic simple rhinitis and preparation method thereof | |
| CN107753626A (en) | A kind of medicine for reducing isoprenaline hydrochloride side effect | |
| CN104547501A (en) | Children traditional Chinese medicine formula for treating acute nasosinusitis | |
| CN105194545B (en) | A kind of Chinese medicine composition for treating asthma | |
| CN114949147A (en) | Traditional Chinese medicine composition for treating chronic pharyngitis as well as preparation method and application thereof | |
| CN116531457A (en) | Traditional Chinese medicine composition for treating chronic pharyngitis and application thereof | |
| CN114732889A (en) | Traditional Chinese medicine composition and traditional Chinese medicine oral preparation for treating bronchial asthma acute attack stage turbid phlegm lung obstruction syndrome | |
| CN103990027B (en) | A kind of atomized liquid for respiratory tract inhalation injury |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20200318 Address after: 655000 Biomedical Health Industry Science Park, No. 51 Ruihe West Road, Qujing City, Yunnan Province Applicant after: Yunnan health testing inspection technology Co., Ltd Address before: 655000 Biomedical Health Industry Science Park, No. 51 Ruihe West Road, Qujing City, Yunnan Province Applicant before: YUNNAN KANGCHUANG BIOLOGICAL MEDICAL TECHNOLOGY HATCHING Co.,Ltd. |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190215 |